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This document discusses the outcomes for patients with secondary central nervous system (CNS) involvement in relapsed or refractory diffuse large B-cell lymphoma (DLBCL) and estimates their eligibility for CAR T-cell therapy. Secondary CNS lymphoma (SCNSL) is associated with poor survival, and there is currently no established standard therapy for this condition. The document presents a study that investigated the outcomes of 145 consecutive SCNSL patients treated in clinical routine and estimated the proportion and outcome of those who could potentially have been eligible for CAR T-cell therapy. The study found that only a small percentage of patients met the eligibility criteria for CAR T-cell therapy. The study suggests that alternative treatment options are needed for these high-risk patients, including CAR T-cell therapy. [Extracted from the article]

Objectives To evaluate health-related quality of life after venous thromboembolism. Methods We conducted a cohort study, TEHS follow-up, including 1040 women with a first episode of venous thromboembolism and 994 women unexposed to venous thromboembolism. Patients were recruited from the “Thrombo Embolism Hormonal Study” (TEHS), a Swedish nation-wide case–control study on risk factors for venous thromboembolism in women 18–64 years of age. Quality of life was measured using SF-36 and VEINES-QoL/VEINES-Sym. Results On average there were no difference in mean SF-36 summary scales scores between exposed and unexposed women. Twenty percent of exposed women developed postthrombotic syndrome during follow-up. Women with postthrombotic syndrome had severely impaired quality of life with lower scores on all scales. Other predictors of low quality of life after venous thromboembolism were age, obesity, physical inactivity, and recurrent venous thromboembolism. Conclusion Long-term quality of life after venous thromboembolism in women was severely impaired among those developing postthrombotic syndrome, while quality of life in women not developing postthrombotic syndrome was similar to a control population. [ABSTRACT FROM AUTHOR]