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1,016 results on '"Ljubicic"'

1. Efficacy and safety of nintedanib and docetaxel in patients with previously treated lung non-squamous non-small cell lung cancer: a multicenter retrospective real-world analysis

Author

Ljubicic Lidija, Janzic Urska, Unk Mojca, Terglav Ana Sophie, Mohorcic Katja, Seiwerth Fran, Bitar Lela, Badovinac Sonja, Plestina Sanja, Korsic Marta, Kukulj Suzana, Samarzija Miroslav, and Jakopovic Marko

Subjects
advanced nsclc, antiangiogenic therapy, docetaxel, nintedanib, real-world data, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The standard first-line systemic treatment for patients with non-oncogene addicted advanced nonsquamous non-small cell lung cancer (NSCLC) is immunotherapy with immune checkpoint inhibitors (ICI) and/or chemotherapy (ChT). Therapy after failing ICI +/− ChT remains an open question, and docetaxel plus nintedanib represent a valid second line option.

Published
2023
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2. Strangeness production in sNN = 3 GeV Au+Au collisions at RHIC

Author

Abdulhamid, M. I., Aboona, B. E., Adam, J., Adamczyk, L., Adams, J. R., Aggarwal, I., Aggarwal, M. M., Ahammed, Z., Aschenauer, E. C., Aslam, S., Atchison, J., Bairathi, V., Ball Cap, J. G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bhosale, S. R., Bielcik, J., Bielcikova, J., Brandenburg, J. D., Broodo, C., Cai, X. Z., Caines, H., Calderón de la Barca Sánchez, M., Cebra, D., Ceska, J., Chakaberia, I., Chaloupka, P., Chan, B. K., Chang, Z., Chatterjee, A., Chen, D., Chen, J., Chen, J. H., Chen, Z., Cheng, J., Cheng, Y., Christie, W., Chu, X., Crawford, H. J., Csanád, M., Dale-Gau, G., Das, A., Deppner, I. M., Dhamija, A., Dixit, P., Dong, X., Drachenberg, J. L., Duckworth, E., Dunlop, J. C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Eyser, O., Fatemi, R., Fazio, S., Feng, C. J., Feng, Y., Finch, E., Fisyak, Y., Flor, F. A., Fu, C., Gagliardi, C. A., Galatyuk, T., Gao, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M. D., Harris, J. W., Harrison-Smith, H., He, W., He, X. H., He, Y., Herrmann, N., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H. Z., Huang, S. L., Huang, T., Huang, Y., Huang, Y., Humanic, T. J., Isshiki, M., Jacobs, W. W., Jalotra, A., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jin, C., Ju, X., Judd, E. G., Kabana, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Keane, D., Khanal, A., Khyzhniak, Y. V., Kikoła, D. P., Kincses, D., Kisel, I., Kiselev, A., Knospe, A. G., Ko, H. S., Kołaś, J., Kosarzewski, L. K., Kumar, L., Labonte, M. C., Lacey, R., Landgraf, J. M., Lauret, J., Lebedev, A., Lee, J. H., Leung, Y. H., Li, C., Li, D., Li, H-S., Li, H., Li, W., Li, X., Li, Y., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M. A., Liu, C., Liu, G., Liu, H., Liu, L., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, T., Lomicky, O., Longacre, R. S., Loyd, E. M., Lu, T., Luo, J., Luo, X. F., Ma, L., Ma, R., Ma, Y. G., Magdy, N., Mallick, D., Manikandhan, R., Margetis, S., Markert, C., Matonoha, O., McNamara, G., Mezhanska, O., Mi, K., Mioduszewski, S., Mohanty, B., Mondal, B., Mondal, M. M., Mooney, I., Mrazkova, J., Nagy, M. I., Nain, A. S., Nam, J. D., Nasim, M., Neff, D., Nelson, J. M., Nie, M., Nigmatkulov, G., Niida, T., Nonaka, T., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B. S., Pal, S., Pandav, A., Panday, A., Pandey, A. K., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B. R., Posik, M., Protzman, T. L., Prozorova, V., Pruthi, N. K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Racz, C., Radhakrishnan, S. K., Rana, A., Ray, R. L., Reed, R., Robertson, C. W., Robotkova, M., Rosales Aguilar, M. A., Roy, D., Roy Chowdhury, P., Ruan, L., Sahoo, A. K., Sahoo, N. R., Sako, H., Salur, S., Sato, S., Schaefer, B. C., Schmidke, W. B., Schmitz, N., Seck, F-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P. V., Shao, T., Sharma, M., Sharma, N., Sharma, R., Sharma, S. R., Sheikh, A. I., Shen, D., Shen, D. Y., Shen, K., Shi, S. S., Shi, Y., Shou, Q. Y., Si, F., Singh, J., Singha, S., Sinha, P., Skoby, M. J., Smirnov, N., Söhngen, Y., Song, Y., Srivastava, B., Stanislaus, T. D. S., Stefaniak, M., Stewart, D. J., Su, Y., Sumbera, M., Sun, C., Sun, X., Sun, Y., Sun, Y., Surrow, B., Svoboda, M., Sweger, Z. W., Tamis, A. C., Tang, A. H., Tang, Z., Tarnowsky, T., Thomas, J. H., Timmins, A. R., Tlusty, D., Todoroki, T., Trentalange, S., Tribedy, P., Tripathy, S. K., Truhlar, T., Trzeciak, B. A., Tsai, O. D., Tsang, C. Y., Tu, Z., Tyler, J., Ullrich, T., Underwood, D. G., Upsal, I., Van Buren, G., Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S. A., Wang, G., Wang, J. S., Wang, J., Wang, K., Wang, X., Wang, Y., Wang, Y., Wang, Y., Wang, Z., Webb, J. C., Weidenkaff, P. C., Westfall, G. D., Wielanek, D., Wieman, H., Wilks, G., Wissink, S. W., Witt, R., Wu, J., Wu, J., Wu, X., Wu, X., Xi, B., Xiao, Z. G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q. H., Xu, Y., Xu, Y., Xu, Z., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Ye, Z., Yi, L., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, W., Zhang, X., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Z. J., Zhang, Z., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, S., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2024
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3. Strangeness production in s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 3 GeV Au+Au collisions at RHIC

Author

The STAR collaboration, M. I. Abdulhamid, B. E. Aboona, J. Adam, L. Adamczyk, J. R. Adams, I. Aggarwal, M. M. Aggarwal, Z. Ahammed, E. C. Aschenauer, S. Aslam, J. Atchison, V. Bairathi, J. G. Ball Cap, K. Barish, R. Bellwied, P. Bhagat, A. Bhasin, S. Bhatta, S. R. Bhosale, J. Bielcik, J. Bielcikova, J. D. Brandenburg, C. Broodo, X. Z. Cai, H. Caines, M. Calderón de la Barca Sánchez, D. Cebra, J. Ceska, I. Chakaberia, P. Chaloupka, B. K. Chan, Z. Chang, A. Chatterjee, D. Chen, J. Chen, J. H. Chen, Z. Chen, J. Cheng, Y. Cheng, W. Christie, X. Chu, H. J. Crawford, M. Csanád, G. Dale-Gau, A. Das, I. M. Deppner, A. Dhamija, P. Dixit, X. Dong, J. L. Drachenberg, E. Duckworth, J. C. Dunlop, J. Engelage, G. Eppley, S. Esumi, O. Evdokimov, O. Eyser, R. Fatemi, S. Fazio, C. J. Feng, Y. Feng, E. Finch, Y. Fisyak, F. A. Flor, C. Fu, C. A. Gagliardi, T. Galatyuk, T. Gao, F. Geurts, N. Ghimire, A. Gibson, K. Gopal, X. Gou, D. Grosnick, A. Gupta, W. Guryn, A. Hamed, Y. Han, S. Harabasz, M. D. Harasty, J. W. Harris, H. Harrison-Smith, W. He, X. H. He, Y. He, N. Herrmann, L. Holub, C. Hu, Q. Hu, Y. Hu, H. Huang, H. Z. Huang, S. L. Huang, T. Huang, Y. Huang, T. J. Humanic, M. Isshiki, W. W. Jacobs, A. Jalotra, C. Jena, A. Jentsch, Y. Ji, J. Jia, C. Jin, X. Ju, E. G. Judd, S. Kabana, D. Kalinkin, K. Kang, D. Kapukchyan, K. Kauder, D. Keane, A. Khanal, Y. V. Khyzhniak, D. P. Kikoła, D. Kincses, I. Kisel, A. Kiselev, A. G. Knospe, H. S. Ko, J. Kołaś, L. K. Kosarzewski, L. Kumar, M. C. Labonte, R. Lacey, J. M. Landgraf, J. Lauret, A. Lebedev, J. H. Lee, Y. H. Leung, C. Li, D. Li, H-S. Li, H. Li, W. Li, X. Li, Y. Li, Z. Li, X. Liang, Y. Liang, R. Licenik, T. Lin, Y. Lin, M. A. Lisa, C. Liu, G. Liu, H. Liu, L. Liu, T. Liu, X. Liu, Y. Liu, Z. Liu, T. Ljubicic, O. Lomicky, R. S. Longacre, E. M. Loyd, T. Lu, J. Luo, X. F. Luo, L. Ma, R. Ma, Y. G. Ma, N. Magdy, D. Mallick, R. Manikandhan, S. Margetis, C. Markert, O. Matonoha, G. McNamara, O. Mezhanska, K. Mi, S. Mioduszewski, B. Mohanty, B. Mondal, M. M. Mondal, I. Mooney, J. Mrazkova, M. I. Nagy, A. S. Nain, J. D. Nam, M. Nasim, D. Neff, J. M. Nelson, M. Nie, G. Nigmatkulov, T. Niida, T. Nonaka, G. Odyniec, A. Ogawa, S. Oh, K. Okubo, B. S. Page, S. Pal, A. Pandav, A. Panday, A. K. Pandey, T. Pani, A. Paul, B. Pawlik, D. Pawlowska, C. Perkins, J. Pluta, B. R. Pokhrel, M. Posik, T. L. Protzman, V. Prozorova, N. K. Pruthi, M. Przybycien, J. Putschke, Z. Qin, H. Qiu, C. Racz, S. K. Radhakrishnan, A. Rana, R. L. Ray, R. Reed, C. W. Robertson, M. Robotkova, M. A. Rosales Aguilar, D. Roy, P. Roy Chowdhury, L. Ruan, A. K. Sahoo, N. R. Sahoo, H. Sako, S. Salur, S. Sato, B. C. Schaefer, W. B. Schmidke, N. Schmitz, F-J. Seck, J. Seger, R. Seto, P. Seyboth, N. Shah, P. V. Shanmuganathan, T. Shao, M. Sharma, N. Sharma, R. Sharma, S. R. Sharma, A. I. Sheikh, D. Shen, D. Y. Shen, K. Shen, S. S. Shi, Y. Shi, Q. Y. Shou, F. Si, J. Singh, S. Singha, P. Sinha, M. J. Skoby, N. Smirnov, Y. Söhngen, Y. Song, B. Srivastava, T. D. S. Stanislaus, M. Stefaniak, D. J. Stewart, Y. Su, M. Sumbera, C. Sun, X. Sun, Y. Sun, B. Surrow, M. Svoboda, Z. W. Sweger, A. C. Tamis, A. H. Tang, Z. Tang, T. Tarnowsky, J. H. Thomas, A. R. Timmins, D. Tlusty, T. Todoroki, S. Trentalange, P. Tribedy, S. K. Tripathy, T. Truhlar, B. A. Trzeciak, O. D. Tsai, C. Y. Tsang, Z. Tu, J. Tyler, T. Ullrich, D. G. Underwood, I. Upsal, G. Van Buren, J. Vanek, I. Vassiliev, V. Verkest, F. Videbæk, S. A. Voloshin, G. Wang, J. S. Wang, J. Wang, K. Wang, X. Wang, Y. Wang, Z. Wang, J. C. Webb, P. C. Weidenkaff, G. D. Westfall, D. Wielanek, H. Wieman, G. Wilks, S. W. Wissink, R. Witt, J. Wu, X. Wu, B. Xi, Z. G. Xiao, G. Xie, W. Xie, H. Xu, N. Xu, Q. H. Xu, Y. Xu, Z. Xu, G. Yan, Z. Yan, C. Yang, Q. Yang, S. Yang, Y. Yang, Z. Ye, L. Yi, Y. Yu, H. Zbroszczyk, W. Zha, C. Zhang, D. Zhang, J. Zhang, S. Zhang, W. Zhang, X. Zhang, Y. Zhang, Z. J. Zhang, Z. Zhang, F. Zhao, J. Zhao, M. Zhao, S. Zhou, Y. Zhou, X. Zhu, M. Zurek, and M. Zyzak

Subjects
Fixed Target Experiments, Relativistic Heavy Ion Physics, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract We report multi-differential measurements of strange hadron production ranging from mid- to target-rapidity in Au+Au collisions at a center-of-momentum energy per nucleon pair of s NN $$ \sqrt{s_{\textrm{NN}}} $$ = 3 GeV with the STAR experiment at RHIC. K S 0 $$ {K}_S^0 $$ meson and Λ hyperon yields are measured via their weak decay channels. Collision centrality and rapidity dependences of the transverse momentum spectra and particle ratios are presented. Particle mass and centrality dependence of the average transverse momenta of Λ and K S 0 $$ {K}_S^0 $$ are compared with other strange particles, providing evidence of the development of hadronic rescattering in such collisions. The 4π yields of each of these strange hadrons show a consistent centrality dependence. Discussions on radial flow, the strange hadron production mechanism, and properties of the medium created in such collisions are presented together with results from hadronic transport and thermal model calculations.

Published
2024
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4. AMPK regulates the maintenance and remodelling of the neuromuscular junction

Author

Sean Y. Ng, Andrew I. Mikhail, Stephanie R. Mattina, Salah A. Mohammed, Shahzeb K. Khan, Eric M. Desjardins, Changhyun Lim, Stuart M. Phillips, Gregory R. Steinberg, and Vladimir Ljubicic

Subjects
Mitochondria, Exercise, Aging, PGC-1α, Acetylcholine receptors, Internal medicine, RC31-1245
Abstract

Objective: The molecular mechanisms underlying the maintenance and adaptability of the neuromuscular junction (NMJ) remain poorly understood. This study aimed to investigate the role of AMP-activated protein kinase (AMPK) as a key regulator of NMJ stability and plasticity. Method: A comprehensive, multifaceted approach was employed, integrating genetic, physiological, and pharmacological methodologies to elucidate the role of skeletal muscle AMPK in modulating the neuromuscular synapse. Results: Our findings reveal an increased abundance of AMPK transcripts within the NMJ and an age-associated decline in AMPK activity and synapse-specific mitochondrial gene expression. Young mice null for skeletal muscle AMPK displayed a neuromuscular phenotype akin to aged animals. Pharmacological AMPK stimulation facilitated its localization in subsynaptic myonuclei, preceded the induction of several NMJ-related transcripts, and enhanced myotube acetylcholine receptor clustering. Exercise-induced AMPK activation in mouse muscle elicited a broad NMJ-related gene response, consistent with human exercise data. Conclusions: These findings highlight a critical role for AMPK in the maintenance and remodeling of the NMJ, highlighting its potential as a therapeutic target for age-related and neuromuscular disorders.

Published
2025
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7. Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS/MS in sera from 2458 healthy subjects aged 0 to 77 years

Author

Frederiksen, Hanne, Johannsen, Trine Holm, Andersen, Stine Ehlern, Petersen, Jørgen Holm, Busch, Alexander Siegfried, Ljubicic, Marie Lindhardt, Fischer, Margit Bistrup, Upners, Emmie N., Hagen, Casper P., Main, Katharina M., Aksglaede, Lise, Jørgensen, Niels, Lund Kårhus, Line, Linneberg, Allan, Andersson, Anna-Maria, Flück, Christa E., and Juul, Anders

Published
2024
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9. Investigating the role of obstructive pulmonary diseases and eosinophil count at admission on all-cause mortality in SARS-CoV-2 patients: A single center registry-based retrospective cohort study

Author

Salai, Grgur, Vrazic, Hrvoje, Kovacevic, Ivona, Janes, Linda Malnar, Marasovic, Ivan, Ranilovic, Darjan, Vukoja, Damir, Zelenika Margeta, Marina, Huljev–Sipos, Ivana, Lalic, Kristina, Spoljaric, Marko, Tekavec-Trkanjec, Jasna, Vergles, Mirna, Lucijanic, Marko, Luksic, Ivica, and Ljubicic, Divo

Published
2023
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16. Erratum to: Evidence of Mass Ordering of Charm and Bottom Quark Energy Loss in Au+Au Collisions at RHIC

Author

Abdallah, M. S., Aboona, B. E., Adam, J., Adamczyk, L., Adams, J. R., Adkins, J. K., Aggarwal, I., Aggarwal, M. M., Ahammed, Z., Anderson, D. M., Aschenauer, E. C., Atchison, J., Bai, X., Bairathi, V., Baker, W., Ball Cap, J. G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bielcik, J., Bielcikova, J., Brandenburg, J. D., Cai, X. Z., Caines, H., de la Barca Sánchez, M. Calderón, Cebra, D., Chakaberia, I., Chaloupka, P., Chan, B. K., Chang, Z., Chatterjee, A., Chattopadhyay, S., Chen, D., Chen, J., Chen, J. H., Chen, X., Chen, Z., Cheng, J., Cheng, Y., Choudhury, S., Christie, W., Chu, X., Crawford, H. J., Csanád, M., Daugherity, M., Deppner, I. M., Dhamija, A., Carlo, L. Di, Didenko, L., Dixit, P., Dong, X., Drachenberg, J. L., Duckworth, E., Dunlop, J. C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Ewigleben, A., Eyser, O., Fatemi, R., Fawzi, F. M., Fazio, S., Feng, C. J., Feng, Y., Finch, E., Fisyak, Y., Francisco, A., Fu, C., Gagliardi, C. A., Galatyuk, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M. D., Harris, J. W., Harrison, H., He, S., He, W., He, X. H., He, Y., Heppelmann, S., Herrmann, N., Hoffman, E., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H. Z., Huang, S. L., Huang, T., Huang, X., Huang, Y., Humanic, T. J., Isenhower, D., Isshiki, M., Jacobs, W. W., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jiang, K., Jin, C., Ju, X., Judd, E. G., Kabana, S., Kabir, M. L., Kagamaster, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Ke, H. W., Keane, D., Kelsey, M., Khyzhniak, Y. V., Kikoła, D. P., Kimelman, B., Kincses, D., Kisel, I., Kiselev, A., Knospe, A. G., Ko, H. S., Kosarzewski, L. K., Kramarik, L., Kumar, L., Kumar, S., Elayavalli, R. Kunnawalkam, Kwasizur, J. H., Lacey, R., Lan, S., Landgraf, J. M., Lauret, J., Lebedev, A., Lee, J. H., Leung, Y. H., Lewis, N., Li, C., Li, C., Li, W., Li, W., Li, X., Li, Y., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M. A., Liu, F., Liu, H., Liu, H., Liu, T., Liu, X., Liu, Y., Ljubicic, T., Llope, W. J., Longacre, R. S., Loyd, E., Lu, T., Lukow, N. S., Luo, X. F., Ma, L., Ma, R., Ma, Y. G., Magdy, N., Mallick, D., Margetis, S., Markert, C., Matis, H. S., Mazer, J. A., McNamara, G., Mioduszewski, S., Mohanty, B., Mondal, M. M., Mooney, I., Mukherjee, A., Nagy, M. I., Nain, A. S., Nam, J. D., Nasim, Md., Nayak, K., Neff, D., Nelson, J. M., Nemes, D. B., Nie, M., Niida, T., Nishitani, R., Nonaka, T., Nunes, A. S., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B. S., Pak, R., Pan, J., Pandav, A., Pandey, A. K., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B. R., Porter, J., Posik, M., Protzman, T., Prozorova, V., Pruthi, N. K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Quintero, A., Racz, C., Radhakrishnan, S. K., Raha, N., Ray, R. L., Reed, R., Ritter, H. G., Robotkova, M., Romero, J. L., Roy, D., Chowdhury, P. Roy, Ruan, L., Sahoo, A. K., Sahoo, N. R., Sako, H., Salur, S., Sato, S., Schmidke, W. B., Schmitz, N., Seck, F.-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P. V., Shao, M., Shao, T., Sharma, R., Sheikh, A. I., Shen, D. Y., Shen, K., Shi, S. S., Shi, Y., Shou, Q. Y., Sichtermann, E. P., Sikora, R., Singh, J., Singha, S., Sinha, P., Skoby, M. J., Smirnov, N., Söhngen, Y., Solyst, W., Song, Y., Srivastava, B., Stanislaus, T. D. S., Stewart, D. J., Stringfellow, B., Suaide, A. A. P., Sumbera, M., Sun, C., Sun, X. M., Sun, X., Sun, Y., Sun, Y., Surrow, B., Sweger, Z. W., Szymanski, P., Tang, A. H., Tang, Z., Tarnowsky, T., Thomas, J. H., Timmins, A. R., Tlusty, D., Todoroki, T., Tomkiel, C. A., Trentalange, S., Tribble, R. E., Tribedy, P., Tripathy, S. K., Truhlar, T., Trzeciak, B. A., Tsai, O. D., Tsang, C. Y., Tu, Z., Ullrich, T., Underwood, D. G., Upsal, I., Buren, G. Van, Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S. A., Wang, F., Wang, G., Wang, J. S., Wang, P., Wang, X., Wang, Y., Wang, Y., Wang, Z., Webb, J. C., Weidenkaff, P. C., Westfall, G. D., Wielanek, D., Wieman, H., Wissink, S. W., Witt, R., Wu, J., Wu, J., Wu, X., Wu, Y., Xi, B., Xiao, Z. G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q. H., Xu, Y., Xu, Z., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, S., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Z. J., Zhang, Z., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, C., Zhou, J., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2023
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17. Measurement of electrons from open heavy-flavor hadron decays in Au+Au collisions at sNN = 200 GeV with the STAR detector

Author

Abdulhamid, M. I., Aboona, B. E., Adam, J., Adamczyk, L., Adams, J. R., Aggarwal, I., Aggarwal, M. M., Ahammed, Z., Anderson, D. M., Aschenauer, E. C., Aslam, S., Atchison, J., Bairathi, V., Baker, W., Ball Cap, J. G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bielcik, J., Bielcikova, J., Brandenburg, J. D., Cai, X. Z., Caines, H., Calderón de la Barca Sánchez, M., Cebra, D., Ceska, J., Chakaberia, I., Chaloupka, P., Chan, B. K., Chang, Z., Chatterjee, A., Chen, D., Chen, J., Chen, J. H., Chen, Z., Cheng, J., Cheng, Y., Choudhury, S., Christie, W., Chu, X., Crawford, H. J., Csanád, M., Dale-Gau, G., Das, A., Daugherity, M., Deppner, I. M., Dhamija, A., Di Carlo, L., Didenko, L., Dixit, P., Dong, X., Drachenberg, J. L., Duckworth, E., Dunlop, J. C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Ewigleben, A., Eyser, O., Fatemi, R., Fazio, S., Feng, C. J., Feng, Y., Finch, E., Fisyak, Y., Flor, F. A., Fu, C., Gagliardi, C. A., Galatyuk, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M. D., Harris, J. W., Harrison-Smith, H., He, W., He, X. H., He, Y., Herrmann, N., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H. Z., Huang, S. L., Huang, T., Huang, X., Huang, Y., Huang, Y., Humanic, T. J., Isenhower, D., Isshiki, M., Jacobs, W. W., Jalotra, A., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jin, C., Ju, X., Judd, E. G., Kabana, S., Kabir, M. L., Kagamaster, S., Kalinkin, D., Kang, K., Kapukchyan, D., Keane, D., Kelsey, M., Khyzhniak, Y. V., Kikoła, D. P., Kimelman, B., Kincses, D., Kisel, I., Kiselev, A., Knospe, A. G., Ko, H. S., Kosarzewski, L. K., Kramarik, L., Kumar, L., Kumar, S., Kunnawalkam Elayavalli, R., Lacey, R., Landgraf, J. M., Lauret, J., Lebedev, A., Lee, J. H., Leung, Y. H., Lewis, N., Li, C., Li, W., Li, X., Li, Y., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lisa, M. A., Liu, C., Liu, F., Liu, G., Liu, H., Liu, H., Liu, L., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, T., Llope, W. J., Lomicky, O., Longacre, R. S., Loyd, E. M., Lu, T., Lukow, N. S., Luo, X. F., Ma, L., Ma, R., Ma, Y. G., Magdy, N., Mallick, D., Margetis, S., Markert, C., Matis, H. S., Mazer, J. A., McNamara, G., Mi, K., Mioduszewski, S., Mohanty, B., Mondal, M. M., Mooney, I., Mukherjee, A., Nagy, M. I., Nain, A. S., Nam, J. D., Nasim, M., Neff, D., Nelson, J. M., Nemes, D. B., Nie, M., Niida, T., Nishitani, R., Nonaka, T., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B. S., Pak, R., Pan, J., Pandav, A., Pandey, A. K., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B. R., Posik, M., Protzman, T., Prozorova, V., Pruthi, N. K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Quintero, A., Racz, C., Radhakrishnan, S. K., Raha, N., Ray, R. L., Reed, R., Ritter, H. G., Robertson, C. W., Robotkova, M., Rosales Aguilar, M. A., Roy, D., Roy Chowdhury, P., Ruan, L., Sahoo, A. K., Sahoo, N. R., Sako, H., Salur, S., Sato, S., Schmidke, W. B., Schmitz, N., Seck, F-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P. V., Shao, T., Sharma, M., Sharma, N., Sharma, R., Sharma, S. R., Sheikh, A. I., Shen, D. Y., Shen, K., Shi, S. S., Shi, Y., Shou, Q. Y., Si, F., Singh, J., Singha, S., Sinha, P., Skoby, M. J., Smirnov, N., Söhngen, Y., Song, Y., Srivastava, B., Stanislaus, T. D. S., Stefaniak, M., Stewart, D. J., Stringfellow, B., Su, Y., Suaide, A. A. P., Sumbera, M., Sun, C., Sun, X., Sun, Y., Sun, Y., Surrow, B., Sweger, Z. W., Szymanski, P., Tamis, A., Tang, A. H., Tang, Z., Tarnowsky, T., Thomas, J. H., Timmins, A. R., Tlusty, D., Todoroki, T., Tomkiel, C. A., Trentalange, S., Tribble, R. E., Tribedy, P., Truhlar, T., Trzeciak, B. A., Tsai, O. D., Tsang, C. Y., Tu, Z., Tyler, J., Ullrich, T., Underwood, D. G., Upsal, I., Van Buren, G., Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S. A., Wang, F., Wang, G., Wang, J. S., Wang, X., Wang, Y., Wang, Y., Wang, Y., Wang, Z., Webb, J. C., Weidenkaff, P. C., Westfall, G. D., Wielanek, D., Wieman, H., Wilks, G., Wissink, S. W., Witt, R., Wu, J., Wu, J., Wu, X., Wu, Y., Xi, B., Xiao, Z. G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q. H., Xu, Y., Xu, Y., Xu, Z., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, W., Zhang, X., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Z. J., Zhang, Z., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, C., Zhou, J., Zhou, S., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2023
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19. Empirical Second-Line Therapy in 5000 Patients of the European Registry on Helicobacter pylori Management (Hp-EuReg)

Author

Fiorinni, Giulia, Saracino, Ilaria Maria, Carrasco, Manuel Pabon, Huerga, Alma Keco, Almajano, Enrique Alfaro, Martinez Dominguez, Samuel Jesus, Galan, Horacio Alonso, Velayos, Benito, Sadornil, Carmen Dueñas, Botargues Bote, Jose Maria, Gonzalez-Cordero, Pedro Luis, Areia, Miguel, Gomez Rodriguez, Blas Jose, Pellicano, Rinaldo, Nuñez, Óscar, Franceschi, Francesco, Alekseenko, Sergey, Perona, Monica, Abdulkhakov, Rustam, Dominguez-Cajal, Manuel, Notari, Pedro Almela, Camarero, Judith Gomez, Moreno, Manuel Jimenez, Algaba, Alicia, Bermejo, Fernando, Tejada, Javier Tejedor, Susanibar, Elida Oblitas, Boltin, Doron, Georgopoulos, Sotirios, OMorain, Colm, Qasim, Asghar, Beales, Ian, Bakulina, Natalia, Fadeenko, Galina, Malfertheiner, Peter, Rosania, Rosa, Ilchishina, Tatiana, Bogomolov, Pavel, Bakulin, Igor, Zaytsev, Oleg, Gravina, Antonietta Gerarda, Romano, Marco, Di Leo, Alfredo, Losurdo, Giuseppe, Grigorieva, Ludmila, Guillena, Pedro Delgado, Marusic, Marinko, Jurcic, Dragan, Dekhnich, Natalia Nikolaevna, Iyo, Eduardo, de la Peña Negro, Luisa Carmen, Baryshnikova, Natalia, Bakanova, Natalia, Simsek, Halis, Simsek, Cem, Gridnyev, Oleksiy, Fernandez-Bermejo, Miguel, Angueira, Teresa, Ruiz-Zorrilla Lopez, Rafael, Gomez, Barbara, Kovacheva-Slavova, Mila, Lahat, Adi, Alcedo, Javier, Campillo, Ana, Belousova, Liya Nikolaevna, Villarroya, Ramon Pajares, Ljubicic, Neven, Nikolic, Marko, González-Santiago, Jesús M., Santamaría, Diego Burgos, Pakhomova, Anna, Sekulic-Spasic, Izabela, Ghisa, Matteo, Farinati, Fabio, Sagdati, Sabir Irfan, Panic, Nikola, Heluwaert, Frederic, Amorena, Edurne, Moreira, Leticia, Esparrach, Gloria Fernandez, Plotnikova, Ekaterina Yuryevna, Kukla, Michal, Kamburov, Victor, Lamuela Calvo, Luis Javier, Rankovic, Ivan, Lavín, Antonio Cuadrado, Lazaro, Yolanda Arguedas, Carrera Agnieszka Dobrowolska, Victor Gonzalez, Eder, Piotr, Kononova, Alla, Nyssen, Olga P., Vaira, Dino, Pérez Aísa, Ángeles, Rodrigo, Luis, Castro-Fernandez, Manuel, Jonaitis, Laimas, Tepes, Bojan, Vologzhanina, Liudmila, Caldas, María, Lanas, Angel, Lucendo, Alfredo J., Bujanda, Luis, Ortuño, Juan, Barrio, Jesús, Huguet, Jose M., Voynovan, Irina, Lasala, Jorge Perez, Sarsenbaeva, Aiman Silkanovna, Fernandez-Salazar, Luis, Molina-Infante, Javier, Jurecic, Natasa Brglez, Gasbarrini, Antonio, Kupčinskas, Juozas, Bordin, Dmitry, Marcos-Pinto, Ricardo, Lerang, Frode, Leja, Marcis, Buzas, Gyorgy M., Niv, Yaron, Rokkas, Theodore, Phull, Perminder, Smith, Sinead, Shvets, Oleg, Venerito, Marino, Milivojevic, Vladimir, Simsek, Ilkay, Lamy, Vincent, Bytzer, Peter, Boyanova, Lyudmila, Kunovský, Lumír, Beglinger, Christoph, Doulberis, Michael, Marlicz, Wojciech, Goldis, Adrian, Tonkić, Ante, Capelle, Lisette, Puig, Ignasi, Megraud, Francis, Morain, Colm O’, and Gisbert, Javier P.

Published
2022
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22. Evidence of Mass Ordering of Charm and Bottom Quark Energy Loss in Au+Au Collisions at RHIC

Author

Abdallah, M. S., Aboona, B. E., Adam, J., Adamczyk, L., Adams, J. R., Adkins, J. K., Aggarwal, I., Aggarwal, M. M., Ahammed, Z., Anderson, D. M., Aschenauer, E. C., Atchison, J., Bairathi, V., Baker, W., Ball Cap, J. G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bielcik, J., Bielcikova, J., Brandenburg, J. D., Cai, X. Z., Caines, H., de la Barca Sánchez, M. Calderón, Cebra, D., Chakaberia, I., Chaloupka, P., Chan, B. K., Chang, Z., Chatterjee, A., Chattopadhyay, S., Chen, D., Chen, J., Chen, J. H., Chen, X., Chen, Z., Cheng, J., Choudhury, S., Christie, W., Chu, X., Crawford, H. J., Csanád, M., Daugherity, M., Deppner, I. M., Dhamija, A., Carlo, L. Di, Didenko, L., Dixit, P., Dong, X., Drachenberg, J. L., Duckworth, E., Dunlop, J. C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Ewigleben, A., Eyser, O., Fatemi, R., Fawzi, F. M., Fazio, S., Feng, C. J., Feng, Y., Finch, E., Fisyak, Y., Francisco, A., Fu, C., Gagliardi, C. A., Galatyuk, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M. D., Harris, J. W., Harrison, H., He, S., He, W., He, X. H., He, Y., Heppelmann, S., Herrmann, N., Hoffman, E., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H. Z., Huang, S. L., Huang, T., Huang, X., Huang, Y., Humanic, T. J., Isenhower, D., Isshiki, M., Jacobs, W. W., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jiang, K., Jin, C., Ju, X., Judd, E. G., Kabana, S., Kabir, M. L., Kagamaster, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Ke, H. W., Keane, D., Kelsey, M., Khyzhniak, Y. V., Kikoła, D. P., Kimelman, B., Kincses, D., Kisel, I., Kiselev, A., Knospe, A. G., Ko, H. S., Kosarzewski, L. K., Kramarik, L., Kumar, L., Kumar, S., Elayavalli, R. Kunnawalkam, Kwasizur, J. H., Lacey, R., Lan, S., Landgraf, J. M., Lauret, J., Lebedev, A., Lee, J. H., Leung, Y. H., Lewis, N., Li, C., Li, C., Li, W., Li, W., Li, X., Li, Y., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M. A., Liu, F., Liu, H., Liu, H., Liu, T., Liu, X., Liu, Y., Ljubicic, T., Llope, W. J., Longacre, R. S., Loyd, E., Lu, T., Lukow, N. S., Luo, X. F., Ma, L., Ma, R., Ma, Y. G., Magdy, N., Mallick, D., Margetis, S., Markert, C., Matis, H. S., Mazer, J. A., McNamara, G., Mioduszewski, S., Mohanty, B., Mondal, M. M., Mooney, I., Mukherjee, A., Nagy, M. I., Nain, A. S., Nam, J. D., Nasim, Md., Nayak, K., Neff, D., Nelson, J. M., Nemes, D. B., Nie, M., Niida, T., Nishitani, R., Nonaka, T., Nunes, A. S., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B. S., Pak, R., Pan, J., Pandav, A., Pandey, A. K., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B. R., Porter, J., Posik, M., Protzman, T., Prozorova, V., Pruthi, N. K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Quintero, A., Racz, C., Radhakrishnan, S. K., Raha, N., Ray, R. L., Reed, R., Ritter, H. G., Robotkova, M., Romero, J. L., Roy, D., Chowdhury, P. Roy, Ruan, L., Sahoo, A. K., Sahoo, N. R., Sako, H., Salur, S., Sato, S., Schmidke, W. B., Schmitz, N., Seck, F-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P. V., Shao, M., Shao, T., Sharma, R., Sheikh, A. I., Shen, D. Y., Shen, K., Shi, S. S., Shi, Y., Shou, Q. Y., Sichtermann, E. P., Sikora, R., Singh, J., Singha, S., Sinha, P., Skoby, M. J., Smirnov, N., Söhngen, Y., Solyst, W., Song, Y., Srivastava, B., Stanislaus, T. D. S., Stewart, D. J., Stringfellow, B., Suaide, A. A. P., Sumbera, M., Sun, C., Sun, X. M., Sun, X., Sun, Y., Sun, Y., Surrow, B., Sweger, Z. W., Szymanski, P., Tang, A. H., Tang, Z., Tarnowsky, T., Thomas, J. H., Timmins, A. R., Tlusty, D., Todoroki, T., Tomkiel, C. A., Trentalange, S., Tribble, R. E., Tribedy, P., Tripathy, S. K., Truhlar, T., Trzeciak, B. A., Tsai, O. D., Tsang, C. Y., Tu, Z., Ullrich, T., Underwood, D. G., Upsal, I., Buren, G. Van, Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S. A., Wang, F., Wang, G., Wang, J. S., Wang, P., Wang, X., Wang, Y., Wang, Y., Wang, Z., Webb, J. C., Weidenkaff, P. C., Westfall, G. D., Wielanek, D., Wieman, H., Wissink, S. W., Witt, R., Wu, J., Wu, J., Wu, Y., Xi, B., Xiao, Z. G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q. H., Xu, Y., Xu, Z., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, S., Zhang, Y., Zhang, Y., Zhang, Y., Zhang, Z. J., Zhang, Z., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, C., Zhou, J., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2022
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23. 'When We're on the Ice, All We Have is Our Inuit Qaujimajatuqangit': Mobilizing Inuit Knowledge as a Sea Ice Safety Adaptation Strategy in Mittimatalik, Nunavut

Author

Wilson, Katherine J., Arreak, Andrew, Itulu, Jamesie, Ljubicic, Gita J., and Bell, Trevor

Subjects
Nunavut -- Environmental aspects, Sea ice -- Environmental aspects, Climatic changes -- Social aspects -- Environmental aspects, Inuit -- Social aspects -- Environmental aspects, Earth sciences, Regional focus/area studies
Abstract

Increased variability in weather and sea ice conditions due to climate change has led to high rates of injury, trauma, and death for Inuit travelling on the sea ice. Contributing to these high rates are the ongoing effects of colonial policies that diminish and disrupt the intergenerational transfer of sea ice Inuit Qaujimajatuqangit (IQ). Despite these challenges, place-based experiential IQ continues to be the most important information source for safe travel on the sea ice. This paper presents an Inuit-led, coproduced, cross-cultural research project in which Inuit youth documented and mobilized sea ice IQ in Mittimatalik (Pond Inlet), Nunavut for safe community sea ice travel. We outline the Inuit youth training to facilitate the terminology and participatory mapping workshops and to document this IQ. We also discuss the IQ that was most important to share, and the mapping and artistic methods used to mobilize this IQ into a booklet, maps, and posters. Inuktitut sea ice terms are the foundation to enable youth with the skills to learn about sea ice IQ with experienced hunters. IQ enables Inuit to interpret and synthesize information from weather forecasts, earth observations, and community-based monitoring to apply to local conditions. Seasonal IQ maps of safe and hazardous sea ice conditions provide travel planning information at spatial and temporal scales that supplemental information sources cannot address. The IQ products mobilize preparedness, situational awareness, navigation, and interpretation skills so Inuit youth can become more self-reliant, as access to technology is not always possible once out on the sea ice. Key words: Inuit Qaujimajatuqangit; knowledge mobilization; sea ice travel safety; climate change adaptation; Inuit self-determination in research La fluctuation accrue des conditions meteorologiques et de l'etat de la glace de mer decoulant du changement climatique se traduit par des taux plus eleves de blessures, de traumatismes et de deces chez les Inuits se deplafant sur la glace de mer. A cela s'ajoutent les effets permanents des politiques coloniales qui amenuisent et perturbent le transfert intergenerationnel de l'Inuit Qaujimajatuqangit (IQ) au sujet de la glace de mer. Malgre ces defis, l'IQ tire de l'experience sur les lieux continue de representer la source d'information la plus importante pour favoriser des deplacements securitaires sur la glace de mer. Cet article presente un projet de recherche interculturel dirige et co-realise par des Inuits dans le cadre duquel de jeunes Inuits ont documente et mobilise l'lQ sur la glace de mer a Mittimatalik (inlet Pond), au Nunavut, en vue de deplacements communautaires securitaires sur la glace de mer. Nous mettons l'accent sur la formation refue par les jeunes Inuits visant a faciliter les ateliers de terminologie et de cartographie participative ainsi qu'a documenter l'IQ en question. Nous discutons egalement de l'IQ le plus important a partager de meme que de la cartographie et des methodes artistiques utilisees pour mobiliser l'IQ dans un cahier, sur des cartes et sur des affiches. Les termes inuktituts propres a la glace de mer servent de fondement pour doter les jeunes des connaissances necessaries pour apprendre l'IQ de la glace de mer avec les chasseurs d'experience. L'IQ permet aux Inuits d'interpreter et de synthetiser l'information en provenance des previsions meteorologiques, des observations de la terre et de la surveillance communautaire afin de l'appliquer aux conditions locales. Les cartes saisonnieres de l'IQ illustrant les conditions securitaires et les conditions dangereuses de la glace de mer fournissent de l'information pour la planification des deplacements a l'echelle spatiale et temporelle que des sources supplementaires ne pourraient fournir. Les produits de l'IQ permettent de mobiliser les competences en preparation, en connaissance de la situation, en navigation et en interpretation pour que les jeunes Inuits puissent devenir plus autonomes, car l'acces a la technologie n'est pas toujours possible lorsqu'ils se trouvent sur la glace de mer. Mots cles : Inuit Qaujimajatuqangit; mobilisation des connaissances; securite des deplacements sur la glace de mer; adaptation au changement climatique; autodetermination des Inuits dans la recherche Traduit pour la revue Arctic par Nicole Giguere. Inuktitut Abstract and Acknowledgement tranlsations by Mishak Allurut, Ikpiarjuk, NU., INTRODUCTION Studies over the past 17 years have shown that climate change is resulting in increasingly dangerous sea ice travel conditions for Inuit (Fox, 2004; Tremblay et al., 2006; Laidler [...]

Published
2021
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27. Polygenic Scores for Adult Testosterone and SHBG Levels Are Associated With Reproductive Hormone Levels in Male Infants.

Author

Busch, Alexander Siegfried, Ljubicic, Marie Lindhardt, Upners, Emmie N, Fischer, Margit Bistrup, Odroniec, Amadeusz, Hagen, Casper P, and Juul, Anders

Subjects
HYPOTHALAMIC-pituitary-gonadal axis, COHORT analysis, PHENOTYPIC plasticity, ADULTS, BLOOD sampling, PUBERTY
Abstract

Context The hypothalamic-pituitary-gonadal axis's transient activity in infancy, i.e, minipuberty, is considered crucial for male reproductive function. Historically, minipuberty has been considered a passive response triggered by the withdrawal of placental steroids at birth. However, given its potential link to adult reproductive function, we hypothesize that minipuberty is a partially genetically regulated process, suggesting a link between the genetic architecture of reproductive hormone concentrations across lifespan. Objective To investigate the association of UK Biobank Study-based polygenic scores (PGS) of adult total testosterone (T) and sex hormone-binding globulin (SHBG) concentrations with trajectories of reproductive hormones concentrations in male infants. Design Prospective, longitudinal birth cohort (The COPENHAGEN Minipuberty Study, 2016-2018, ClinTrial: NCT02784184). Individual PGSs in male infants derived from published literature were calculated for total T and SHBG. The associations with mean SD scores (SDS) of reproductive hormone concentrations in infancy were tested. Setting Population-based. Patients or other participants Healthy, male, term, singleton newborns were followed with repeated clinical examinations including blood sampling during a 1-year follow-up (n = 109). Main outcome measures Circulating reproductive hormone concentrations. Results T-PGSadult were significant associated with mean T-SDSinfancy, mean SHBG-SDSinfancy, and mean LH-SDSinfancy (P =.02, <.001 and.03, with r2 = 0.05, 0.21 and 0.04, respectively). SHBG-PGSadult was significantly associated with mean SHBG-SDSinfancy (P <.001, r2 = 0.18). T-PGSadult explained 5% and 21% of the phenotypic variation in infancy of mean T-SDSinfancy and SHBG-SDSinfancy, respectively. Conclusion Our findings suggest that the genetic architecture underlying total T and SHBG in adults also associates with hormone concentrations and their trajectories during infancy. [ABSTRACT FROM AUTHOR]

Published
2024
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28. The Use of Weather, Water, Ice, and Climate (WWIC) Information in the Polar Regions: What Is Known after the Decadelong Polar Prediction Project?

Author

Heinrich, Victoria J., Stewart, Emma J., Liggett, Daniela, Carrasco, Jorge F., Dawson, Jackie, Lamers, Machiel, Ljubicic, Gita J., Jeuring, Jelmer, and Thoman, Rick

Abstract

The polar regions are facing a wide range of compounding challenges, from climate change to increased human activity. Infrastructure, rescue services, and disaster response capabilities are limited in these remote environments. Relevant and usable weather, water, ice, and climate (WWIC) information is vital for safety, activity success, adaptation, and environmental protection. This has been a key focus for the World Meteorological Organization's (WMO) Polar Prediction Project (PPP), and in particular its "Societal and Economic Research and Applications" (PPP-SERA) Task Team, which together over a decade have sought to understand polar WWIC information use in relation to operational needs, constraints, and decision contexts to inform the development of relevant services. To understand research progress and gaps on WWIC information use during the PPP (2013–23), we undertook a systematic bibliometric review of aligned scholarly peer-reviewed journal articles (n = 43), examining collaborations, topics, methods, and regional differences. Themes to emerge included activity and context, human factors, information needs, situational awareness, experience, local and Indigenous knowledge, and sharing of information. We observed an uneven representation of disciplinary backgrounds, geographic locations, research topics, and sectoral foci. Our review signifies an overall lack of Antarctic WWIC services research and a dominant focus on Arctic sea ice operations and risks. We noted with concern a mismatch between user needs and services provided. Our findings can help to improve WWIC services' dissemination, communication effectiveness, and actionable knowledge provision for users and guide future research as the critical need for salient weather services across the polar regions remains beyond the PPP. Significance Statement: Every day, people in the Arctic and Antarctic use weather, water, ice, and climate information to plan and carry out outdoor activities and operations in a safe way. Despite advances in numerical weather prediction, technology, and product development, barriers to accessing and effectively communicating high-quality usable observations, forecasts, and actionable knowledge remain. Poorer services, prediction accuracy, and interpretation are exacerbated by a lack of integrated social science research on relevant topics and a mismatch between the services provided and user needs. As a result, continued user engagement, research focusing on information use, risk communication, decision-making processes, and the application of science for services remain highly relevant to reducing risks and improving safety for people living, visiting, and working in the polar regions. [ABSTRACT FROM AUTHOR]

Published
2024
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35. THE HANDS' MEASURE: ESSAYS HONOURING LEAH AKSAAJUQ OTAK'S CONTRIBUTIONS TO ARCTIC SCIENCE

Author

Ljubicic, Gita

Subjects
The Hand's Measure: Essays Honouring Leah Aksaajuq Otak's Contribution to Arctic Science (Essay collection) -- MacDonald, John -- Wachowich, Nancy, Books -- Book reviews, Earth sciences, Regional focus/area studies
Abstract

THE HANDS' MEASURE: ESSAYS HONOURING LEAH AKSAAJUQ OTAK'S CONTRIBUTIONS TO ARCTIC SCIENCE. Edited by JOHN MACDONALD and NANCY WACHOWICH. Iqaluit, Nunavut: Nunavut Arctic College Media, 2018. ISBN 978-1-897568-41-5. 396 p., [...]

Published
2020

38. Measurements of charged-particle multiplicity dependence of higher-order net-proton cumulants in p + p collisions at [formula omitted] GeV from STAR at RHIC

Author

Abdulhamid, M.I., Aboona, B.E., Adam, J., Adamczyk, L., Adams, J.R., Aggarwal, I., Aggarwal, M.M., Ahammed, Z., Aschenauer, E.C., Aslam, S., Atchison, J., Bairathi, V., Ball Cap, J.G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bhosale, S.R., Bielcik, J., Bielcikova, J., Brandenburg, J.D., Broodo, C., Cai, X.Z., Caines, H., Calderón de la Barca Sánchez, M., Cebra, D., Ceska, J., Chakaberia, I., Chaloupka, P., Chan, B.K., Chang, Z., Chatterjee, A., Chen, D., Chen, J., Chen, J.H., Chen, Z., Cheng, J., Cheng, Y., Christie, W., Chu, X., Crawford, H.J., Csanád, M., Dale-Gau, G., Das, A., Deppner, I.M., Dhamija, A., Dixit, P., Dong, X., Drachenberg, J.L., Duckworth, E., Dunlop, J.C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Eyser, O., Fatemi, R., Fazio, S., Feng, C.J., Feng, Y., Finch, E., Fisyak, Y., Flor, F.A., Fu, C., Gagliardi, C.A., Galatyuk, T., Gao, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M.D., Harris, J.W., Harrison-Smith, H., He, W., He, X.H., He, Y., Herrmann, N., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H.Z., Huang, S.L., Huang, T., Huang, Y., Humanic, T.J., Isshiki, M., Jacobs, W.W., Jalotra, A., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jin, C., Ju, X., Judd, E.G., Kabana, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Keane, D., Khanal, A., Khyzhniak, Y.V., Kikoła, D.P., Kincses, D., Kisel, I., Kiselev, A., Knospe, A.G., Ko, H.S., Kołaś, J., Kosarzewski, L.K., Kumar, L., Labonte, M.C., Lacey, R., Landgraf, J.M., Lauret, J., Lebedev, A., Lee, J.H., Leung, Y.H., Li, C., Li, D., Li, H-S., Li, H., Li, W., Li, X., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M.A., Liu, C., Liu, G., Liu, H., Liu, L., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, T., Lomicky, O., Longacre, R.S., Loyd, E.M., Lu, T., Luo, J., Luo, X.F., Ma, L., Ma, R., Ma, Y.G., Magdy, N., Mallick, D., Manikandhan, R., Margetis, S., Markert, C., Matonoha, O., McNamara, G., Mezhanska, O., Mi, K., Mioduszewski, S., Mohanty, B., Mondal, B., Mondal, M.M., Mooney, I., Mrazkova, J., Nagy, M.I., Nain, A.S., Nam, J.D., Nasim, M., Neff, D., Nelson, J.M., Nie, M., Nigmatkulov, G., Niida, T., Nishitani, R., Nonaka, T., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B.S., Pal, S., Pandav, A., Panday, A., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B.R., Posik, M., Protzman, T., Prozorova, V., Pruthi, N.K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Racz, C., Radhakrishnan, S.K., Rana, A., Ray, R.L., Reed, R., Robertson, C.W., Robotkova, M., Rosales Aguilar, M.A., Roy, D., Roy Chowdhury, P., Ruan, L., Sahoo, A.K., Sahoo, N.R., Sako, H., Salur, S., Sato, S., Schaefer, B.C., Schmidke, W.B., Schmitz, N., Seck, F-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P.V., Shao, T., Sharma, M., Sharma, N., Sharma, R., Sharma, S.R., Sheikh, A.I., Shen, D., Shen, D.Y., Shen, K., Shi, S.S., Shi, Y., Shou, Q.Y., Si, F., Singh, J., Singha, S., Sinha, P., Skoby, M.J., Smirnov, N., Söhngen, Y., Song, Y., Srivastava, B., Stanislaus, T.D.S., Stefaniak, M., Stewart, D.J., Su, Y., Sumbera, M., Sun, C., Sun, X., Sun, Y., Surrow, B., Svoboda, M., Sweger, Z.W., Tamis, A.C., Tang, A.H., Tang, Z., Tarnowsky, T., Thomas, J.H., Timmins, A.R., Tlusty, D., Todoroki, T., Trentalange, S., Tribedy, P., Tripathy, S.K., Truhlar, T., Trzeciak, B.A., Tsai, O.D., Tsang, C.Y., Tu, Z., Tyler, J., Ullrich, T., Underwood, D.G., Upsal, I., Van Buren, G., Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S.A., Wang, G., Wang, J.S., Wang, J., Wang, K., Wang, X., Wang, Y., Wang, Z., Webb, J.C., Weidenkaff, P.C., Westfall, G.D., Wielanek, D., Wieman, H., Wilks, G., Wissink, S.W., Witt, R., Wu, J., Wu, X., Xi, B., Xiao, Z.G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q.H., Xu, Y., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Yi, L., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, W., Zhang, X., Zhang, Y., Zhang, Z.J., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, S., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2024
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39. CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy.

Author

Stouth, Derek W., vanLieshout, Tiffany L., Mikhail, Andrew I., Ng, Sean Y., Raziee, Rozhin, Edgett, Brittany A., Vasam, Goutham, Webb, Erin K., Gilotra, Kevin S., Markou, Matthew, Pineda, Hannah C., Bettencourt-Mora, Brianna G., Noor, Haleema, Moll, Zachary, Bittner, Megan E., Gurd, Brendon J., Menzies, Keir J., and Ljubicic, Vladimir

Subjects
UBIQUITIN ligases, TRANSCRIPTION factors, FORKHEAD transcription factors, CHROMATIN-remodeling complexes, MUSCULAR atrophy, SKELETAL muscle, TUBULINS, PROTEIN arginine methyltransferases
Abstract

CARM1 (coactivator associated arginine methyltransferase 1) has recently emerged as a powerful regulator of skeletal muscle biology. However, the molecular mechanisms by which the methyltransferase remodels muscle remain to be fully understood. In this study, carm1 skeletal muscle-specific knockout (mKO) mice exhibited lower muscle mass with dysregulated macroautophagic/autophagic and atrophic signaling, including depressed AMP-activated protein kinase (AMPK) site-specific phosphorylation of ULK1 (unc-51 like autophagy activating kinase 1; Ser555) and FOXO3 (forkhead box O3; Ser588), as well as MTOR (mechanistic target of rapamycin kinase)-induced inhibition of ULK1 (Ser757), along with AKT/protein kinase B site-specific suppression of FOXO1 (Ser256) and FOXO3 (Ser253). In addition to lower mitophagy and autophagy flux in skeletal muscle, carm1 mKO led to increased mitochondrial PRKN/parkin accumulation, which suggests that CARM1 is required for basal mitochondrial turnover and autophagic clearance. carm1 deletion also elicited PPARGC1A (PPARG coactivator 1 alpha) activity and a slower, more oxidative muscle phenotype. As such, these carm1 mKO-evoked adaptations disrupted mitophagy and autophagy induction during food deprivation and collectively served to mitigate fasting-induced muscle atrophy. Furthermore, at the threshold of muscle atrophy during food deprivation experiments in humans, skeletal muscle CARM1 activity decreased similarly to our observations in mice, and was accompanied by site-specific activation of ULK1 (Ser757), highlighting the translational impact of the methyltransferase in human skeletal muscle. Taken together, our results indicate that CARM1 governs mitophagic, autophagic, and atrophic processes fundamental to the maintenance and remodeling of muscle mass. Targeting the enzyme may provide new therapeutic approaches for mitigating skeletal muscle atrophy. Abbreviation: ADMA: asymmetric dimethylarginine; AKT/protein kinase B: AKT serine/threonine kinase; AMPK: AMP-activated protein kinase; ATG: autophagy related; BECN1: beclin 1; BNIP3: BCL2 interacting protein 3; CARM1: coactivator associated arginine methyltransferase 1; Col: colchicine; CSA: cross-sectional area; CTNS: cystinosin, lysosomal cystine transporter; EDL: extensor digitorum longus; FBXO32/MAFbx: F-box protein 32; FOXO: forkhead box O; GAST: gastrocnemius; H2O2: hydrogen peroxide; IMF: intermyofibrillar; LAMP1: lysosomal associated membrane protein 1; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; mKO: skeletal muscle-specific knockout; MMA: monomethylarginine; MTOR: mechanistic target of rapamycin kinase; MYH: myosin heavy chain; NFE2L2/NRF2: NFE2 like bZIP transcription factor 2; OXPHOS: oxidative phosphorylation; PABPC1/PABP1: poly(A) binding protein cytoplasmic 1; PPARGC1A/PGC-1α: PPARG coactivator 1 alpha; PRKN/parkin: parkin RBR E3 ubiquitin protein ligase; PRMT: protein arginine methyltransferase; Sal: saline; SDMA: symmetric dimethylarginine; SIRT1: sirtuin 1; SKP2: S-phase kinase associated protein 2; SMARCC1/BAF155: SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1; SOL: soleus; SQSTM1/p62: sequestosome 1; SS: subsarcolemmal; TA: tibialis anterior; TFAM: transcription factor A, mitochondrial; TFEB: transcription factor EB; TOMM20: translocase of outer mitochondrial membrane 20; TRIM63/MuRF1: tripartite motif containing 63; ULK1: unc-51 like autophagy activating kinase 1; VPS11: VPS11 core subunit of CORVET and HOPS complexes; WT: wild-type. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Antibiotics Prescribing Pattern and Quality of Prescribing in Croatian Dental Practices—5-Year National Study.

Author

Petrac, Lucija, Gvozdanovic, Katarina, Perkovic, Vjera, Petek Zugaj, Nikolina, and Ljubicic, Neven

Subjects
DRUG prescribing, PRACTICE of dentistry, INAPPROPRIATE prescribing (Medicine), ANTIBIOTICS, CLAVULANIC acid
Abstract

Purpose: Antibiotic resistance is one of the biggest threats to global health today. The aim of this study was to analyze antibiotic prescribing patterns and quality of prescribing in Croatian dental practices over a 5-year period. Methods: This is a retrospective observational study based on the analysis of the electronic prescriptions (medicines in ATC groups J01 and P01) from dental practices in Croatia prescribed from 1 January 2015 to 31 December 2019. Prescriptions were retrieved from the Croatian Health Insurance Fund (HZZO). The analyses included the number of prescriptions, type and quantity of prescribed drugs, indication, and the patient's and prescriber's characteristics. Results: The consumption increased from 1.98 DID in 2015, to 2.10 DID in 2019. The most prescribed antibiotic was Amoxicillin with clavulanic acid followed by Amoxicillin, Clindamycin, Metronidazole and Cefalexin. The analyses showed that 29.79% of antibiotics were not prescribed in accordance with the contemporary guidelines for the proper use of antibiotics. Additionally, 22% of antibiotics were prescribed in inconclusive indications. Conclusion: The research showed an increase in antibiotic consumption over five years along with unnecessary prescribing of antibiotics in cases with no indications for its use. The development of national guidelines for antibiotic use is necessary. [ABSTRACT FROM AUTHOR]

Published
2024
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41. High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

Author

Yi Zhu, Tobias Weiss, Qiushi Zhang, Rui Sun, Bo Wang, Xiao Yi, Zhicheng Wu, Huanhuan Gao, Xue Cai, Guan Ruan, Tiansheng Zhu, Chao Xu, Sai Lou, Xiaoyan Yu, Ludovic Gillet, Peter Blattmann, Karim Saba, Christian D. Fankhauser, Michael B. Schmid, Dorothea Rutishauser, Jelena Ljubicic, Ailsa Christiansen, Christine Fritz, Niels J. Rupp, Cedric Poyet, Elisabeth Rushing, Michael Weller, Patrick Roth, Eugenia Haralambieva, Silvia Hofer, Chen Chen, Wolfram Jochum, Xiaofei Gao, Xiaodong Teng, Lirong Chen, Qing Zhong, Peter J. Wild, Ruedi Aebersold, and Tiannan Guo

Subjects
biomarker, FFPE, pressure cycling technology, proteome, SWATH, tumor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a pressure cycling technology (PCT)‐SWATH mass spectrometry workflow to analyze FFPE tissue proteomes and applied it to the stratification of prostate cancer (PCa) and diffuse large B‐cell lymphoma (DLBCL) samples. We show that the proteome patterns of FFPE PCa tissue samples and their analogous fresh‐frozen (FF) counterparts have a high degree of similarity and we confirmed multiple proteins consistently regulated in PCa tissues in an independent sample cohort. We further demonstrate temporal stability of proteome patterns from FFPE samples that were stored between 1 and 15 years in a biobank and show a high degree of the proteome pattern similarity between two types of histological regions in small FFPE samples, that is, punched tissue biopsies and thin tissue sections of micrometer thickness, despite the existence of a certain degree of biological variations. Applying the method to two independent DLBCL cohorts, we identified myeloperoxidase, a peroxidase enzyme, as a novel prognostic marker. In summary, this study presents a robust proteomic method to analyze bulk and biopsy FFPE tissues and reports the first systematic comparison of proteome maps generated from FFPE and FF samples. Our data demonstrate the practicality and superiority of FFPE over FF samples for proteome in biomarker discovery. Promising biomarker candidates for PCa and DLBCL have been discovered.

Published
2019
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44. Collision-energy dependence of deuteron cumulants and proton-deuteron correlations in Au+Au collisions at RHIC

Author

Abdulhamid, M.I., Aboona, B.E., Adam, J., Adamczyk, L., Adams, J.R., Aggarwal, I., Aggarwal, M.M., Ahammed, Z., Aschenauer, E.C., Aslam, S., Atchison, J., Bairathi, V., Ball Cap, J.G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bhosale, S.R., Bielcik, J., Bielcikova, J., Brandenburg, J.D., Broodo, C., Cai, X.Z., Caines, H., Calderón de la Barca Sánchez, M., Cebra, D., Ceska, J., Chakaberia, I., Chaloupka, P., Chan, B.K., Chang, Z., Chatterjee, A., Chen, D., Chen, J., Chen, J.H., Chen, Z., Cheng, J., Cheng, Y., Choudhury, S., Christie, W., Chu, X., Crawford, H.J., Csanád, M., Dale-Gau, G., Das, A., Deppner, I.M., Dhamija, A., Dixit, P., Dong, X., Drachenberg, J.L., Duckworth, E., Dunlop, J.C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Eyser, O., Fatemi, R., Fazio, S., Feng, C.J., Feng, Y., Finch, E., Fisyak, Y., Flor, F.A., Fu, C., Gagliardi, C.A., Galatyuk, T., Gao, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M.D., Harris, J.W., Harrison-Smith, H., He, W., He, X.H., He, Y., Herrmann, N., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H.Z., Huang, S.L., Huang, T., Huang, X., Huang, Y., Humanic, T.J., Isshiki, M., Jacobs, W.W., Jalotra, A., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jin, C., Ju, X., Judd, E.G., Kabana, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Keane, D., Khanal, A., Khyzhniak, Y.V., Kikoła, D.P., Kincses, D., Kisel, I., Kiselev, A., Knospe, A.G., Ko, H.S., Kosarzewski, L.K., Kumar, L., Labonte, M.C., Lacey, R., Landgraf, J.M., Lauret, J., Lebedev, A., Lee, J.H., Leung, Y.H., Lewis, N., Li, C., Li, D., Li, H-S., Li, H., Li, W., Li, X., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M.A., Liu, C., Liu, G., Liu, H., Liu, L., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, T., Lomicky, O., Longacre, R.S., Loyd, E.M., Lu, T., Luo, J., Luo, X.F., Ma, L., Ma, R., Ma, Y.G., Magdy, N., Mallick, D., Manikandhan, R., Margetis, S., Markert, C., Matis, H.S., McNamara, G., Mezhanska, O., Mi, K., Mioduszewski, S., Mohanty, B., Mondal, M.M., Mooney, I., Nagy, M.I., Nain, A.S., Nam, J.D., Nasim, M., Neff, D., Nelson, J.M., Nemes, D.B., Nie, M., Nigmatkulov, G., Niida, T., Nonaka, T., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B.S., Pak, R., Pal, S., Pandav, A., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B.R., Posik, M., Protzman, T., Prozorova, V., Pruthi, N.K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Racz, C., Radhakrishnan, S.K., Rana, A., Ray, R.L., Reed, R., Ritter, H.G., Robertson, C.W., Robotkova, M., Rosales Aguilar, M.A., Roy, D., Roy Chowdhury, P., Ruan, L., Sahoo, A.K., Sahoo, N.R., Sako, H., Salur, S., Sato, S., Schaefer, B.C., Schmidke, W.B., Schmitz, N., Seck, F-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P.V., Shao, T., Sharma, M., Sharma, N., Sharma, R., Sharma, S.R., Sheikh, A.I., Shen, D., Shen, D.Y., Shen, K., Shi, S.S., Shi, Y., Shou, Q.Y., Si, F., Singh, J., Singha, S., Sinha, P., Skoby, M.J., Smirnov, N., Söhngen, Y., Song, Y., Srivastava, B., Stanislaus, T.D.S., Stefaniak, M., Stewart, D.J., Stringfellow, B., Su, Y., Suaide, A.A.P., Sumbera, M., Sun, C., Sun, X., Sun, Y., Surrow, B., Sweger, Z.W., Tamis, A.C., Tang, A.H., Tang, Z., Tarnowsky, T., Thomas, J.H., Timmins, A.R., Tlusty, D., Todoroki, T., Trentalange, S., Tribedy, P., Tripathy, S.K., Truhlar, T., Trzeciak, B.A., Tsai, O.D., Tsang, C.Y., Tu, Z., Tyler, J., Ullrich, T., Underwood, D.G., Upsal, I., Van Buren, G., Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S.A., Wang, F., Wang, G., Wang, J.S., Wang, J., Wang, K., Wang, X., Wang, Y., Wang, Z., Webb, J.C., Weidenkaff, P.C., Westfall, G.D., Wielanek, D., Wieman, H., Wilks, G., Wissink, S.W., Witt, R., Wu, J., Wu, X., Xi, B., Xiao, Z.G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q.H., Xu, Y., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, W., Zhang, X., Zhang, Y., Zhang, Z.J., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, J., Zhou, S., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2024
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45. Measurements of the Z0/γ⁎ cross section and transverse single spin asymmetry in 510 GeV p + p collisions

Author

Abdulhamid, M.I., Aboona, B.E., Adam, J., Adamczyk, L., Adams, J.R., Aggarwal, I., Aggarwal, M.M., Ahammed, Z., Aschenauer, E.C., Aslam, S., Atchison, J., Bairathi, V., Ball Cap, J.G., Barish, K., Bellwied, R., Bhagat, P., Bhasin, A., Bhatta, S., Bhosale, S.R., Bielcik, J., Bielcikova, J., Brandenburg, J.D., Broodo, C., Cai, X.Z., Caines, H., Calderón de la Barca Sánchez, M., Cebra, D., Ceska, J., Chakaberia, I., Chaloupka, P., Chan, B.K., Chang, Z., Chatterjee, A., Chen, D., Chen, J., Chen, J.H., Chen, Z., Cheng, J., Cheng, Y., Choudhury, S., Christie, W., Chu, X., Crawford, H.J., Csanád, M., Dale-Gau, G., Das, A., Deppner, I.M., Dhamija, A., Dixit, P., Dong, X., Drachenberg, J.L., Duckworth, E., Dunlop, J.C., Engelage, J., Eppley, G., Esumi, S., Evdokimov, O., Eyser, O., Fatemi, R., Fazio, S., Feng, C.J., Feng, Y., Finch, E., Fisyak, Y., Flor, F.A., Fu, C., Gagliardi, C.A., Galatyuk, T., Gao, T., Geurts, F., Ghimire, N., Gibson, A., Gopal, K., Gou, X., Grosnick, D., Gupta, A., Guryn, W., Hamed, A., Han, Y., Harabasz, S., Harasty, M.D., Harris, J.W., Harrison-Smith, H., He, W., He, X.H., He, Y., Herrmann, N., Holub, L., Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H.Z., Huang, S.L., Huang, T., Huang, X., Huang, Y., Humanic, T.J., Isshiki, M., Jacobs, W.W., Jalotra, A., Jena, C., Jentsch, A., Ji, Y., Jia, J., Jin, C., Ju, X., Judd, E.G., Kabana, S., Kalinkin, D., Kang, K., Kapukchyan, D., Kauder, K., Keane, D., Khanal, A., Khyzhniak, Y.V., Kikoła, D.P., Kincses, D., Kisel, I., Kiselev, A., Knospe, A.G., Ko, H.S., Kosarzewski, L.K., Kumar, L., Labonte, M.C., Lacey, R., Landgraf, J.M., Lauret, J., Lebedev, A., Lee, J.H., Leung, Y.H., Lewis, N., Li, C., Li, D., Li, H.-S., Li, H., Li, W., Li, X., Li, Y., Li, Z., Liang, X., Liang, Y., Licenik, R., Lin, T., Lin, Y., Lisa, M.A., Liu, C., Liu, G., Liu, H., Liu, L., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, T., Lomicky, O., Longacre, R.S., Loyd, E.M., Lu, T., Luo, J., Luo, X.F., Ma, L., Ma, R., Ma, Y.G., Magdy, N., Mallick, D., Manikandhan, R., Margetis, S., Markert, C., McNamara, G., Mezhanska, O., Mi, K., Mioduszewski, S., Mohanty, B., Mondal, M.M., Mooney, I., Mrazkova, J., Nagy, M.I., Nain, A.S., Nam, J.D., Nasim, M., Neff, D., Nelson, J.M., Nemes, D.B., Nie, M., Nigmatkulov, G., Niida, T., Nonaka, T., Odyniec, G., Ogawa, A., Oh, S., Okubo, K., Page, B.S., Pak, R., Pal, S., Pandav, A., Pandey, A.K., Pani, T., Paul, A., Pawlik, B., Pawlowska, D., Perkins, C., Pluta, J., Pokhrel, B.R., Posik, M., Protzman, T., Prozorova, V., Pruthi, N.K., Przybycien, M., Putschke, J., Qin, Z., Qiu, H., Racz, C., Radhakrishnan, S.K., Rana, A., Ray, R.L., Reed, R., Robertson, C.W., Robotkova, M., Rosales Aguilar, M.A., Roy, D., Roy Chowdhury, P., Ruan, L., Sahoo, A.K., Sahoo, N.R., Sako, H., Salur, S., Sato, S., Schaefer, B.C., Schmidke, W.B., Schmitz, N., Seck, F.-J., Seger, J., Seto, R., Seyboth, P., Shah, N., Shanmuganathan, P.V., Shao, T., Sharma, M., Sharma, N., Sharma, R., Sharma, S.R., Sheikh, A.I., Shen, D., Shen, D.Y., Shen, K., Shi, S.S., Shi, Y., Shou, Q.Y., Si, F., Singh, J., Singha, S., Sinha, P., Skoby, M.J., Smirnov, N., Söhngen, Y., Song, Y., Srivastava, B., Stanislaus, T.D.S., Stefaniak, M., Stewart, D.J., Su, Y., Sumbera, M., Sun, C., Sun, X., Sun, Y., Surrow, B., Svoboda, M., Sweger, Z.W., Tamis, A.C., Tang, A.H., Tang, Z., Tarnowsky, T., Thomas, J.H., Timmins, A.R., Tlusty, D., Todoroki, T., Trentalange, S., Tribedy, P., Tripathy, S.K., Truhlar, T., Trzeciak, B.A., Tsai, O.D., Tsang, C.Y., Tu, Z., Tyler, J., Ullrich, T., Underwood, D.G., Upsal, I., Van Buren, G., Vanek, J., Vassiliev, I., Verkest, V., Videbæk, F., Voloshin, S.A., Wang, F., Wang, G., Wang, J.S., Wang, J., Wang, K., Wang, X., Wang, Y., Wang, Z., Webb, J.C., Weidenkaff, P.C., Westfall, G.D., Wielanek, D., Wieman, H., Wilks, G., Wissink, S.W., Witt, R., Wu, J., Wu, X., Xi, B., Xiao, Z.G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q.H., Xu, Y., Xu, Z., Yan, G., Yan, Z., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, H., Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, W., Zhang, X., Zhang, Y., Zhang, Z.J., Zhang, Z., Zhao, F., Zhao, J., Zhao, M., Zhou, J., Zhou, S., Zhou, Y., Zhu, X., Zurek, M., and Zyzak, M.

Published
2024
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46. Aerobic exercise elicits clinical adaptations in myotonic dystrophy type 1 patients independently of pathophysiological changes

Author

Mikhail, Andrew I., Nagy, Peter L., Manta, Katherine, Rouse, Nicholas, Manta, Alexander, Ng, Sean Y., Nagy, Michael F., Smith, Paul, Lu, Jian-Qiang, Nederveen, Joshua P., Ljubicic, Vladimir, and Tarnopolsky, Mark A.

Subjects
Aerobic exercises -- Health aspects, Myotonic dystrophy -- Care and treatment -- Development and progression -- Genetic aspects, Cycling -- Health aspects, Health care industry
Abstract

BACKGROUND. Myotonic dystrophy type 1 (DM1) is a complex life-limiting neuromuscular disorder characterized by severe skeletal muscle atrophy, weakness, and cardiorespiratory defects. Exercised DM1 mice exhibit numerous physiological benefits that are underpinned by reduced CUG foci and improved alternative splicing. However, the efficacy of physical activity in patients is unknown. METHODS. Eleven genetically diagnosed DM1 patients were recruited to examine the extent to which 12 weeks of cycling can recuperate clinical and physiological metrics. Furthermore, we studied the underlying molecular mechanisms through which exercise elicits benefits in skeletal muscle of DM1 patients. RESULTS. DM1 was associated with impaired muscle function, fitness, and lung capacity. Cycling evoked several clinical, physical, and metabolic advantages in DM1 patients. We highlight that exercise- induced molecular and cellular alterations in patients do not conform with previously published data in murine models and propose a significant role of mitochondrial function in DM1 pathology. Finally, we discovered a subset of small nucleolar RNAs (snoRNAs) that correlated to indicators of disease severity. CONCLUSION. With no available cures, our data support the efficacy of exercise as a primary intervention to partially mitigate the clinical progression of DM1. Additionally, we provide evidence for the involvement of snoRNAs and other noncoding RNAs in DM1 pathophysiology. TRIAL REGISTRATION. This trial was approved by the HiREB committee (no. 7901) and registered under ClinicalTrials.gov (NCT04187482). FUNDING. Neil and Leanne Petroff. Canadian Institutes of Health Research Foundation (no. 143325)., Introduction Myotonic dystrophy type 1 (DM1) is the most commonly diagnosed muscular dystrophy among adults and the second most prevalent of all muscular dystrophies (1). It is a progressive neuromuscular [...]

Published
2022
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