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Your search keyword '"Liu, Mingyao"' showing total 1,670 results
Start Over Author "Liu, Mingyao" Publication Type Academic Journals
1,670 results on '"Liu, Mingyao"'

9. Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src

Author

Li, Zhenxi, Yang, Xinghai, Fu, Ruifeng, Wu, Zhipeng, Xu, Shengzhao, Jiao, Jian, Qian, Ming, Zhang, Long, Wu, Chunbiao, Xie, Tianying, Yao, Jiqiang, Wu, Zhixiang, Li, Wenjun, Ma, Guoli, You, Yu, Chen, Yihua, Zhang, Han-kun, Cheng, Yiyun, Tang, Xiaolong, Wu, Pengfei, Lian, Gewei, Wei, Haifeng, Zhao, Jian, Xu, Jianrong, Ai, Lianzhong, Siwko, Stefan, Wang, Yue, Ding, Jin, Song, Gaojie, Luo, Jian, Liu, Mingyao, and Xiao, Jianru

Published
2024
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12. Prevention and control of land subsidence and earth fissures in Suzhou–Wuxi–Changzhou region

Author

ZHU Jinqi, GONG Xulong, YU Jun, ZHANG Yun, ZHANG Yan, YE Shujun, WANG Caihui, XU Shugang, WU Jianqiang, WANG Guangya, LIU Mingyao, GU Chunsheng, MIN Wang, and GONG Yabing

Subjects
suzhou–wuxi–changzhou region, land subsidence, earth fissures, genetic mechanism, numerical simulation, prevention and control management, Geology, QE1-996.5
Abstract

Objective The Suzhou–Wuxi–Changzhou region is one of the most severely affected areas by land subsidence, both in China and globally. In the early 1970s, land subsidence occurred and resulted in the formation of ground fissures caused by differential subsidence, thus resulting in significant economic losses. In this century, the rate of ground subsidence has decreased, with some areas experiencing regional ground resilience. The unique developmental history of ground subsidence allows one to comprehensively interpret its evolutionary process and causal mechanisms. This study aims to unravel the life cycle and driving forces of land subsidence in the Suzhou–Wuxi–Changzhou region. Methods To achieve this, a multifaceted approach was employed, including long-term and large-scale monitoring of three-dimensional seepage, stress, and strain, complemented by physical experimental models and numerical simulations. An analysis was conducted to synthesize the macro-evolutionary patterns and causal mechanisms of land subsidence and the formation of ground fissures. Results and Conclusion The findings indicate that land subsidence in the Suzhou–Wuxi–Changzhou region exhibits distinct characteristics that evolve through five discernible stages: initiation, rapid development, deceleration, stagnation, and rebound. The development of land subsidence is intricately connected to groundwater extraction, with stratum deformation arising predominantly from the compaction and dewatering of aquifers and aquitards due to pumping. During the subsidence phase, primary aquifer sand and contiguous aquitards are identified as the primary contributors to subsidence. By dissecting the causal mechanisms of land subsidence and ground fissures, this study delineates the spatiotemporal evolution of the structural compression and rebound of strata under varying conditions of deep groundwater exploitation, restriction, and prohibition, along with their respective contributions to subsidence. Ground fissures, which act as a secondary geological hazard at certain stages of subsidence, exhibit a spatial distribution and occurrence time that are closely related to groundwater levels, land subsidence, bedrock undulations, and soil-layer structural disparities. The life cycle of ground fissures can be encapsulated by the mechanical processes of compression, tension, shearing, and rebound, which highlights the triggers and critical thresholds for fissure formation due to differential subsidence. An integrated “sky–air–ground” monitoring system that can perform full-section fiber-optic monitoring in geological boreholes and amalgamates diverse technical methods is established to obtain scientific and granular data support for land-subsidence control and prevention. Furthermore, an innovative finite-element coupling interface element method customized for regional and site-specific scales is developed. This method successfully simulates the mechanisms of stratum deformation as well as the genesis and propagation of ground fissures under complex three-dimensional geological conditions, thus facilitating the precise identification and management of subsidence and fissure prone areas. Significance This study highlights the government’s land subsidence control measures at various stages, which are characterized by technological innovations such as groundwater extraction restrictions and bans, thus setting a precedent for land subsidence management and groundwater resource stewardship in other provinces and cities across China.

Published
2024
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15. Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Author

Chen, Liang, Zhu, Biyun, Ru, Gaomeng, Meng, Haowei, Yan, Yongchang, Hong, Mengjia, Zhang, Dan, Luan, Changming, Zhang, Shun, Wu, Hao, Gao, Hongyi, Bai, Sijia, Li, Changqing, Ding, Ruoyi, Xue, Niannian, Lei, Zhixin, Chen, Yuting, Guan, Yuting, Siwko, Stefan, Cheng, Yiyun, Song, Gaojie, Wang, Liren, Yi, Chengqi, Liu, Mingyao, and Li, Dali

Published
2024
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17. Allogeneic CD19-targeted CAR-T therapy in patients with severe myositis and systemic sclerosis

Author

Wang, Xiaobing, Wu, Xin, Tan, Binghe, Zhu, Liang, Zhang, Yi, Lin, Li, Xiao, Yi, Sun, An, Wan, Xinyi, Liu, Shiyuan, Liu, Yanfang, Ta, Na, Zhang, Hang, Song, Jialin, Li, Ting, Zhou, Ling, Yin, Jian, Ye, Lingying, Lu, Hongjuan, Hong, Jinwei, Cheng, Hui, Wang, Ping, Li, Weiqing, Chen, Jianfeng, Zhang, Jin, Luo, Jing, Huang, Miaozhen, Guo, Lehang, Pan, Xiaoming, Jin, Yi, Ye, Wenjing, Dai, Lie, Zhu, Jian, Sun, Lingyun, Zheng, Biao, Li, Dali, He, Yanran, Liu, Mingyao, Wu, Huaxiang, Du, Bing, and Xu, Huji

Published
2024
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33. Reproducibility of the Rod Photoreceptor Response Depends Critically on the Concentration of the Phosphodiesterase Effector Enzyme.

Author

Morshedian, Ala, Sendek, Gabriela, Ng, Sze Yin, Boyd, Kimberly, Radu, Roxana A, Liu, Mingyao, Artemyev, Nikolai O, Sampath, Alapakkam P, and Fain, Gordon L

Subjects
Eye Disease and Disorders of Vision, Neurosciences, Neurodegenerative, 2.1 Biological and endogenous factors, Aetiology, Animals, Cyclic GMP, Mice, Phosphoric Diester Hydrolases, Reproducibility of Results, Retina, Retinal Rod Photoreceptor Cells, GAF A domain, phosphodiesterase, rod photoreceptor, sensitivity, single-photon response, transduction, Medical and Health Sciences, Psychology and Cognitive Sciences, Neurology & Neurosurgery
Abstract

The high sensitivity of night vision requires that rod photoreceptors reliably and reproducibly signal the absorption of single photons, a process that depends on tight regulation of intracellular cGMP concentration through the phototransduction cascade. Here in the mouse (Mus musculus), we studied a single-site D167A mutation of the gene for the α subunit of rod photoreceptor phosphodiesterase (PDEA), made with the aim of removing a noncatalytic binding site for cGMP. This mutation unexpectedly eliminated nearly all PDEA expression and reduced expression of the β subunit (PDEB) to ∼5%-10% of WT. The remaining PDE had nearly normal specific activity; degeneration was slow, with 50%-60% of rods remaining after 6 months. Responses were larger and more sensitive than normal but slower in rise and decay, probably from slower dark turnover of cGMP. Remarkably, responses became much less reproducible than WT, with response variance increasing for amplitude by over 10-fold, and for latency and time-to-peak by >100-fold. We hypothesize that the increase in variance is the result of greater variability in the dark-resting concentration of cGMP, produced by spatial and temporal nonuniformity in spontaneous PDE activity. This variability decreased as stimuli were made brighter, presumably because of greater spatial uniformity of phototransduction and the approach to saturation. We conclude that the constancy of the rod response depends critically on PDE expression to maintain adequate spontaneous PDE activity, so that the concentration of second messenger is relatively uniform throughout the outer segment.SIGNIFICANCE STATEMENT Rod photoreceptors in the vertebrate retina reliably signal the absorption of single photons of light by generating responses that are remarkably reproducible in amplitude and waveform. We show that this reproducibility depends critically on the concentration of the effector enzyme phosphodiesterase (PDE), which metabolizes the second messenger cGMP and generates rod light responses. In rods with the D167A mutation of the α subunit of PDE, only 5%-10% of PDE is expressed. Single-photon responses then become much more variable than in WT rods. We think this variability is caused by spatial and temporal inhomogeneity in the concentration of cGMP in darkness, so that photons absorbed in different parts of the cell produce responses of greatly varying amplitude and waveform.

Published
2022

44. Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Author

Chen, Liang, Zhu, Biyun, Ru, Gaomeng, Meng, Haowei, Yan, Yongchang, Hong, Mengjia, Zhang, Dan, Luan, Changming, Zhang, Shun, Wu, Hao, Gao, Hongyi, Bai, Sijia, Li, Changqing, Ding, Ruoyi, Xue, Niannian, Lei, Zhixin, Chen, Yuting, Guan, Yuting, Siwko, Stefan, Cheng, Yiyun, Song, Gaojie, Wang, Liren, Yi, Chengqi, Liu, Mingyao, and Li, Dali

Published
2023
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