119 results on '"Libardi, Cleiton Augusto"'
Search Results
2. Effects of Resistance Training Overload Progression Protocols on Strength and Muscle Mass.
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Chaves, Talisson Santos, Scarpelli, Maíra Camargo, Bergamasco, João Guilherme Almeida, Silva, Deivid Gomes da, Medalha Junior, Ricardo Alessandro, Dias, Nathalia Fernanda, Bittencourt, Diego, Carello Filho, Paulo Cesar, Angleri, Vitor, Nóbrega, Sanmy Rocha, Roberts, Michael D., Ugrinowitsch, Carlos, and Libardi, Cleiton Augusto
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EXERCISE physiology ,MEDICAL protocols ,CROSS-sectional method ,MUSCULAR hypertrophy ,STATISTICAL sampling ,RANDOMIZED controlled trials ,RESISTANCE training ,MUSCLE strength ,EXPERIMENTAL design ,CONTROL groups ,PRE-tests & post-tests ,LEAN body mass ,COMPARATIVE studies ,MUSCLE contraction - Abstract
The aim of this study was to compare the effects of progressive overload in resistance training on muscle strength and cross-sectional area (CSA) by specifically comparing the impact of increasing load (LOADprog) versus an increase in repetitions (REPSprog). We used a within-subject experimental design in which 39 previously untrained young persons (20 men and 19 women) had their legs randomized to LOADprog and REPSprog. Outcomes were assessed before and after 10 weeks of training. Muscle strength was assessed using the one repetition maximum (1RM) test on the leg extension exercise, and the CSA of the vastus lateralis was assessed by ultrasonography. Both protocols increased 1RM values from pre (LOADprog: 52.90±16.32 kg; REPSprog: 51.67±15.84 kg) to post (LOADprog: 69.05±18.55 kg, REPSprog: 66.82±17.95 kg), with no difference between them (P +>+0.05). Similarly, both protocols also increased in CSA values from pre (LOADprog: 21.34±4.71 cm²; REPSprog: 21.08±4.62 cm²) to post (LOADprog: 23.53±5.41 cm², REPSprog: 23.39±5.19 cm²), with no difference between them (P +>+0.05). In conclusion, our findings indicate that the progression of overload through load or repetitions can be used to promote gains in strength and muscle hypertrophy in young men and women in the early stages of training. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Suspension training vs. traditional resistance training: effects on muscle mass, strength and functional performance in older adults
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Soligon, Samuel Domingos, da Silva, Deivid Gomes, Bergamasco, João Guilherme Almeida, Angleri, Vitor, Júnior, Ricardo Alessandro Medalha, Dias, Nathalia Fernanda, Nóbrega, Sanmy Rocha, de Castro Cesar, Marcelo, and Libardi, Cleiton Augusto
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- 2020
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4. The effect of passive mobilization associated with blood flow restriction and combined with electrical stimulation on cardiorespiratory safety, neuromuscular adaptations, physical function, and quality of life in comatose patients in an ICU: a randomized controlled clinical trial
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de Campos Biazon, Thaís Marina Pires, Libardi, Cleiton Augusto, Junior, Jose Carlos Bonjorno, Caruso, Flávia Rossi, da Silva Destro, Tamara Rodrigues, Molina, Naiara Garcia, Borghi-Silva, Audrey, and Mendes, Renata Gonçalves
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- 2021
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5. Effects of Blood Flow Restriction Combined With Resistance Training or Neuromuscular Electrostimulation on Muscle Cross-Sectional Area.
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Almeida Bergamasco, João Guilherme, Alvarez, Ieda Fernanda, de Campos Biazon, Thais Marina Pires, Ugrinowitsch, Carlos, and Libardi, Cleiton Augusto
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RESISTANCE training ,COMPUTER software ,STATISTICS ,INFERENTIAL statistics ,ULTRASONIC imaging ,SAMPLE size (Statistics) ,CONFIDENCE intervals ,BLOOD flow restriction training ,EFFECT sizes (Statistics) ,MUSCULAR hypertrophy ,FISHER exact test ,COMPARATIVE studies ,T-test (Statistics) ,ELECTRIC stimulation ,QUADRICEPS muscle ,DESCRIPTIVE statistics ,DATA analysis ,LONGITUDINAL method - Abstract
Context: Low-load resistance training (LL) and neuromuscular electrostimulation (NES), both combined with blood flow restriction (BFR), emerge as effective strategies to maintain or increase muscle mass. It is well established that LL-BFR promotes similar increases in muscle cross-sectional area (CSA) and lower rating of perceived exertion (RPE) and pain compared with traditional resistance training protocols. On the other hand, only 2 studies with conflicting results have investigated the effects of NES-BFR on CSA, RPE, and pain. In addition, no study directly compared LL-BFR and NES-BFR. Objective: The aim of the study was to compare the effects of LL-BFR and NES-BFR on vastus lateralis CSA, RPE, and pain. Individual response for muscle hypertrophy was also compared between protocols. Design: Intrasubject longitudinal study. Setting: University research laboratory. Intervention: Fifteen healthy young males (age = 23 [5] y; weight = 77.6 [11.3] kg; height = 1.76 [0.08] m). Main outcome measures: Vastus lateralis CSA was measured through ultrasound at baseline (pre) and after 20 training sessions (post). The RPE and pain responses were obtained through modified 10-point scales, handled during all training sessions. Results: Both protocols demonstrated significant increases in muscle CSA (P < .0001). However, the LL-BFR demonstrated significantly greater CSA changes compared with NES-BFR (LL-BFR = 11.2%, NES-BFR = 4.6%; P < .0001). Comparing individual increases in CSA, 12 subjects (85.7% of the sample) presented greater muscle hypertrophy for LL-BFR than for the NES-BFR protocol. In addition, LL-BFR produced significantly lower RPE and pain responses (P < .0001). Conclusions: The LL-BFR produced significantly greater increases in CSA with significant less RPE and pain than NES-BFR. In addition, LL-BFR resulted in greater individual muscle hypertrophy responses for most subjects compared with NES-BFR. [ABSTRACT FROM AUTHOR]
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- 2022
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6. Resistance training combined with blood flow restriction in cirrhosis: study protocol for a randomized controlled trial
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Nóbrega, Sanmy Rocha, Chachá, Silvana Gama Florencio, and Libardi, Cleiton Augusto
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- 2020
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7. The Effect of a Resistance Training Session on Physiological and Thermoregulatory Measures of Sub-maximal Running Performance in the Heat in Heat-Acclimatized Men
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Doma, Kenji, Nicholls, Anthony, Gahreman, Daniel, Damas, Felipe, Libardi, Cleiton Augusto, and Sinclair, Wade
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- 2019
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8. Effects of resistance training in gray matter density of elderly
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Fontes, Eduardo Bodnariuc, Libardi, Cleiton Augusto, Castellano, Gabriela, Okano, Alexandre Hideki, Fernandes, Paula Teixeira, Chacon-Mikahil, Mara Patricia, Ugrinowitsch, Carlos, Cavaglieri, Claudia Regina, and Li, Li Min
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- 2017
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9. Crescent pyramid and drop-set systems do not promote greater strength gains, muscle hypertrophy, and changes on muscle architecture compared with traditional resistance training in well-trained men
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Angleri, Vitor, Ugrinowitsch, Carlos, and Libardi, Cleiton Augusto
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- 2017
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10. Comparison in responses to maximal eccentric exercise between elbow flexors and knee extensors of older adults
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Nogueira, Felipe Romano Damas, Libardi, Cleiton Augusto, Nosaka, Kazunori, Vechin, Felipe Cassaro, Cavaglieri, Claudia Regina, and Chacon-Mikahil, Mara Patricia Traina
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- 2014
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11. Interrelated but Not Time-Aligned Response in Myogenic Regulatory Factors Demethylation and mRNA Expression after Divergent Exercise Bouts.
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TELLES, GUILHERME DEFANTE, LIBARDI, CLEITON AUGUSTO, CONCEIÇÃO, MIGUEL SOARES, VECHIN, FELIPE CASSARO, LIXANDRÃO, MANOEL EMÍLIO, MANGONE, FLAVIA REGINA ROTEA, PAVANELLI, ANA CAROLINA, NAGAI, MARIA APARECIDA, CAMERA, DONNY MICHAEL, HAWLEY, JOHN A., and UGRINOWITSCH, CARLOS
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MUSCLE protein metabolism , *RESISTANCE training , *OXYGEN consumption , *EXERCISE physiology , *DEMETHYLATION , *GENE expression , *COMPARATIVE studies , *MESSENGER RNA , *DESCRIPTIVE statistics , *RESEARCH funding , *HIGH-intensity interval training , *EPIGENOMICS - Abstract
Introduction: DNA methylation regulates exercise-induced changes in the skeletal muscle transcriptome. However, the specificity and the time course responses in the myogenic regulatory factors DNA methylation and mRNA expression after divergent exercise modes are unknown. Purpose: This study aimed to compare the time course changes in DNA methylation and mRNA expression for selected myogenic regulatory factors (MYOD1 , MYF5 , and MYF6) immediately after, 4 h after, and 8 h after a single bout of resistance exercise (RE), high-intensity interval exercise (HIIE), and concurrent exercise (CE). Methods: Nine healthy but untrained males (age, 23.9 ± 2.8 yr; body mass, 70.1 ± 14.9 kg; peak oxygen uptake [V̇O2peak], 41.4 ± 5.2 mL·kg−1·min−1; mean ± SD) performed a counterbalanced, randomized order of RE (4 × 8–12 repetition maximum), HIIE (12 × 1 min sprints at V̇O2peak running velocity), and CE (RE followed by HIIE). Skeletal muscle biopsies (vastus lateralis) were taken before (REST) immediately (0 h), 4 h, and 8 h after each exercise bout. Results: Compared with REST, MYOD1 , MYF5 , and MYF6 , mean methylation across all CpGs analyzed was reduced after 4 and 8 h in response to all exercise protocols (P < 0.05). Reduced levels of MYOD1 methylation were observed after HIIE and CE compared with RE (P < 0.05). Compared with REST, all exercise bouts increased mRNA expression over time (MYOD1 at 4 and 8 h, and MYF6 at 4 h; P < 0.05). MYF5 mRNA expression was lower after 4 h compared with 0 h and higher at 8 h compared with 4 h (P < 0.05). Conclusions: We observed an interrelated but not time-aligned response between the exercise-induced changes in myogenic regulatory factors demethylation and mRNA expression after divergent exercise modes. Despite divergent contractile stimuli, changes in DNA methylation and mRNA expression in skeletal muscle were largely confined to the late (4–8 h) recovery period and similar between the different exercise challenges. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Blood-Flow Restriction Resistance Exercise Promotes Lower Pain and Ratings of Perceived Exertion Compared With Either High- or Low-Intensity Resistance Exercise Performed to Muscular Failure.
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Lixandrão, Manoel E., Roschel, Hamilton, Ugrinowitsch, Carlos, Miquelini, Maira, Alvarez, leda F., and Libardi, Cleiton Augusto
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EXERCISE & psychology ,PAIN & psychology ,BLOOD circulation ,COMPARATIVE studies ,CROSSOVER trials ,EXERCISE ,EXERCISE physiology ,MEDICAL protocols ,MUSCLE strength ,RESEARCH funding ,PAIN measurement ,BODY mass index ,RANDOMIZED controlled trials ,PRE-tests & post-tests ,EXERCISE intensity ,DATA analysis software ,SKELETAL muscle ,DESCRIPTIVE statistics ,RESISTANCE training - Abstract
Context: Given the comparable muscle hypertrophy constantly observed between blood-flow restriction exercise (BFR-RE) and conventional resistance exercise, understanding their particular rating of perceived exertion (RPE) and pain may help to better prescribe exercise at a low-discomfort level, thus increasing its feasibility. Design: Randomized crossover study. Objective: To compare the RPE and pain response between conventional high- (HI-RE) and low-intensity resistance exercise (LI-RE) protocols to failure with a nonmuscular failure LI-RE associated with BFR-RE. Participants: A total of 12 men (age: 20 [3] y; body mass: 73.5 [9] kg; height: 174 [6] cm). Interventions: Four sets of 45° leg-press exercises in 3 different conditions: (1) BFR-RE (15 repetitions; 30% 1-repetition maximum), (2) HI-RE (80% 1-repetition maximum to muscular failure), and (3) LI-RE (30% 1-repetition maximum to muscular failure). Main Outcome Measures: RPE and pain were assessed immediately before exercise session and after the end of each of the 4 sets. Results: RPE and pain levels increased throughout the exercise sets for all RE protocols (all, Ps < .05). HI-RE and LI-RE protocols showed similar increase in RPE and pain levels during all exercise sets (P < .05); however, both protocols demonstrated higher RPE and pain response compared with BFR-RE after each of the 4 sets (all Ps < .05 between-group comparisons). Conclusions: Our results demonstrated that both HI-RE and LI-RE to muscular failure resulted in similar and significant increases in RPE and pain levels, regardless of exercise intensity. In addition, nonmuscular failure BFR-RE also increased RPE and pain response, however, to a lower extent compared with either HI-RE or LI-RE. [ABSTRACT FROM AUTHOR]
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- 2019
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13. Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction
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CONCEIÇÃO, MIGUEL SOARES, CHACON-MIKAHIL, MARA PATRICIA TRAINA, TELLES, GUILHERME DEFANTE, LIBARDI, CLEITON AUGUSTO, JÚNIOR, EDSON MANOEL MENDES, VECHIN, FELIPE CASSARO, DE ANDRADE, ANDRÉ LUIS LUGNANI, GÁSPARI, ARTHUR FERNANDES, BRUM, PATRÍCIA CHAKUR, CAVAGLIERI, CLÁUDIA REGINA, SERAG, SARA, SPIEGELMAN, BRUCE M., HAWLEY, JOHN A., and CAMERA, DONNY M.
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- 2016
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14. Combined Training Reduces Subclinical Inflammation in Obese Middle-Age Men
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BRUNELLI, DIEGO T., CHACON-MIKAHIL, MARA PATRÍCIA T., GÁSPARI, ARTHUR F., LOPES, WENDELL ARTHUR, BONGANHA, VALÉRIA, BONFANTE, IVAN LUIZ P., BELLOTTO, MARIA LUISA, LIBARDI, CLEITON AUGUSTO, and CAVAGLIERI, CLÁUDIA REGINA
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- 2015
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15. Effects of eccentric exercise on systemic concentrations of pro- and anti-inflammatory cytokines and prostaglandin (E2): comparison between young and postmenopausal women
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Conceição, Miguel Soares, Libardi, Cleiton Augusto, Nogueira, Felipe Romano Damas, Bonganha, Valéria, Gáspari, Arthur Fernandes, Chacon-Mikahil, Mara Patrícia Traina, Cavaglieri, Cláudia Regina, and Madruga, Vera Aparecida
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- 2012
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16. Exercise-Induced Circulating microRNAs: Potential Key Factors in the Control of Breast Cancer.
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Telles, Guilherme Defante, Conceição, Miguel Soares, Vechin, Felipe Cassaro, Libardi, Cleiton Augusto, Mori, Marcelo Alves da Silva, Derchain, Sophie, and Ugrinowitsch, Carlos
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BREAST cancer ,CELL communication ,MICRORNA ,SKELETAL muscle ,EXERCISE therapy - Abstract
Losses in skeletal muscle mass, strength, and metabolic function are harmful in the pathophysiology of serious diseases, including breast cancer. Physical exercise training is an effective non-pharmacological strategy to improve health and quality of life in patients with breast cancer, mainly through positive effects on skeletal muscle mass, strength, and metabolic function. Emerging evidence has also highlighted the potential of exercise-induced crosstalk between skeletal muscle and cancer cells as one of the mechanisms controlling breast cancer progression. This intercellular communication seems to be mediated by a group of skeletal muscle molecules released in the bloodstream known as myokines. Among the myokines, exercise-induced circulating microRNAs (c-miRNAs) are deemed to mediate the antitumoral effects produced by exercise training through the control of key cellular processes, such as proliferation, metabolism, and signal transduction. However, there are still many open questions regarding the molecular basis of the exercise-induced effects on c-miRNA on human breast cancer cells. Here, we present evidence regarding the effect of exercise training on c-miRNA expression in breast cancer, along with the current gaps in the literature and future perspectives. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Low-Load Resistance Training Performed to Muscle Failure or Near Muscle Failure Does Not Promote Additional Gains on Muscle Strength, Hypertrophy, and Functional Performance of Older Adults.
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Bergamasco, João Guilherme Almeida, da Silva, Deivid Gomes, Bittencourt, Diego Fernandes, de Oliveira, Ramon Martins, Júnior, José Carlos Bonjorno, Caruso, Flávia Rossi, Godoi, Daniela, Borghi-Silva, Audrey, and Libardi, Cleiton Augusto
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RESISTANCE training ,TORQUE ,NEUROPHYSIOLOGY ,ANALYSIS of variance ,HYPERTROPHY ,GAIT in humans ,EFFECT sizes (Statistics) ,EXERCISE physiology ,NEUROMUSCULAR system ,HEALTH outcome assessment ,RANDOMIZED controlled trials ,BODY movement ,MUSCLE strength ,DESCRIPTIVE statistics ,STATISTICAL sampling ,FATIGUE (Physiology) ,DATA analysis software - Abstract
Bergamasco, JGA, Gomes da Silva, D, Bittencourt, DF, Martins de Oliveira, R, Júnior, JCB, Caruso, FC, Godoi, D, Borghi-Silva, A, and Libardi, CA. Low-load resistance training performed to muscle failure or near muscle failure does not promote additional gains on muscle strength, hypertrophy, and functional performance of older adults. J Strength Cond Res 36(5): 1209–1215, 2022—The aim of the present study was to compare the effects of low-load resistance training (RT) protocols performed to failure (FAI), to voluntary interruption (VOL), and with a fixed low repetitions (FIX) on muscle strength, hypertrophy, and functional performance in older adults. Forty-one subjects (60–77 years) were randomized into one of the RT protocols (FAI, VOL, or FIX) and completed 12 weeks of RT at 40% of 1 repetition maximum (1RM), twice a week. The assessments included 1RM test, muscle cross-sectional area (CSA), rate of torque development (RTD), and functional performance (chair stand [CS], habitual gait speed [HGS], maximal gait speed [MGS], and timed up-and-go [TUG]). All protocols significantly increased 1RM values from Pre (FAI: 318.3 ± 116.3 kg; VOL: 342.9 ± 93.7 kg; FIX: 328.0 ± 107.2 kg) to Post (FAI: 393.0 ± 143.1 kg, 23.5%; VOL: 423.0 ± 114.5 kg, 23.3%; FIX: 397.8 ± 94.6 kg, 21.3%; p < 0.0001 for all groups). Regarding CS, all protocols showed significant improvements from Pre (FAI: 11.5 ± 2.4 seconds; VOL: 12.1 ± 2.5 seconds; FIX: 11.3 ± 1.1 seconds) to Post (FAI: 10.5 ± 1.1 seconds, −8.5%, p = 0.001; VOL: 10.3 ± 1.5 seconds, −15.1%, p = 0.001; FIX: 11.0 ± 1.1, −3.2%, p = 0.001). Habitual gait speed values increased significantly from Pre (FAI: 1.3 ± 0.2 m·s
−1 ; VOL: 1.3 ± 0.1 m·s−1 ; FIX: 1.3 ± 0.1 m·s−1 ) to Post (FAI: 1.4 ± 0.2 m·s−1 , 2.5%, p = 0.03; VOL: 1.4 ± 0.2 m·s−1 , 5.2%, p = 0.036; FIX: 1.4 ± 0.1 m·s−1 , 5.7%, p = 0.03). No significant differences between protocols were found (p > 0.05). In addition, there were no significant changes in CSA, RTD, MGS, and TUG for any protocols (p > 0.05). In conclusion, low-load RT performed without muscle failure promotes significant improvements in muscle strength and some parameters of functional performance in older adults. [ABSTRACT FROM AUTHOR]- Published
- 2022
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18. Resistance training variable manipulations are less relevant than intrinsic biology in affecting muscle fiber hypertrophy.
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Angleri, Vitor, Damas, Felipe, Phillips, Stuart M., Selistre‐de‐Araujo, Heloisa Sobreiro, Cornachione, Anabelle Silva, Stotzer, Uliana Sbeguen, Santanielo, Natalia, Soligon, Samuel Domingos, Costa, Luiz Augusto Riani, Lixandrão, Manoel Emílio, Conceição, Miguel Soares, Vechin, Felipe Cassaro, Ugrinowitsch, Carlos, and Libardi, Cleiton Augusto
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RESISTANCE training ,MUSCLES ,MUSCULAR hypertrophy ,EXERCISE physiology ,RANDOMIZED controlled trials ,COMPARATIVE studies ,PRE-tests & post-tests ,DESCRIPTIVE statistics ,STATISTICAL sampling - Abstract
We aimed to investigate whether muscle fiber cross‐sectional area (fCSA) and associated molecular processes could be differently affected at the group and individual level by manipulating resistance training (RT) variables. Twenty resistance‐trained subjects had each leg randomly allocated to either a standard RT (RT‐CON: without specific variables manipulations) or a variable RT (RT‐VAR: manipulation of load, volume, muscle action, and rest interval at each RT session). Muscle fCSA, satellite cell (SC) pool, myonuclei content, and gene expression were assessed before and after training (chronic effect). Gene expression was assessed 24 h after the last training session (acute effect). RT‐CON and RT‐VAR increased fCSA and myonuclei domain in type I and II fibers after training (p < 0.05). SC and myonuclei content did not change for both conditions (p > 0.05). Pax‐7, MyoD, MMP‐2 and COL3A1 (chronic) and MGF, Pax‐7, and MMP‐9 (acute) increased similar for RT‐CON and RT‐VAR (p < 0.05). The increase in acute MyoG expression was significantly higher for the RT‐VAR than RT‐CON (p < 0.05). We found significant correlation between RT‐CON and RT‐VAR for the fCSA changes (r = 0.89). fCSA changes were also correlated to satellite cells (r = 0.42) and myonuclei (r = 0.50) changes. Heatmap analyses showed coupled changes in fCSA, SC, and myonuclei responses at the individual level, regardless of the RT protocol. The high between and low within‐subject variability regardless of RT protocol suggests that the intrinsic biological factors seem to be more important to explain the magnitude of fCSA gains in resistance‐trained subjects. [ABSTRACT FROM AUTHOR]
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- 2022
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19. Individual Muscle Adaptations in different Resistance Training Systems in Well-Trained Men.
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Angleri, Vitor, Ugrinowitsch, Carlos, and Libardi, Cleiton Augusto
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SKELETAL muscle physiology ,RESISTANCE training ,SKELETAL muscle ,RANGE of motion of joints ,MEN ,PHYSICAL training & conditioning ,EXERCISE physiology ,PHYSIOLOGICAL adaptation ,PRE-tests & post-tests ,EXERCISE intensity ,MUSCLE strength ,DESCRIPTIVE statistics - Abstract
Using a within-subject design we compared the individual responses between drop-set (DS) vs. traditional resistance training (TRAD) (n=16) and crescent pyramid (CP) vs. TRAD (n=15). Muscle cross-sectional area (CSA), leg press and leg extension 1 repetition maximum (1-RM) were assessed pre and post training. At group level, CSA increased from pre to post (DS: 7.8% vs. TRAD: 7.5%, P =0.02; CP: 7.5% vs. TRAD: 7.8%, P =0.02). All protocols increased the 1-RM from pre to post for leg press (DS: 24.9% vs. TRAD: 26.8%, P < 0.0001; CP: 27.3% vs. TRAD:2 6.3%, P < 0.0001) and leg extension (DS: 17.1% vs. TRAD: 17.3%, P < 0.0001; CP: 17.0% vs. TRAD: 16.6%, P < 0.0001). Individual analysis for CSA demonstrated no differences between protocols in 15 subjects. For leg press 1-RM, 5 subjects responded more to TRAD, 2 to DS and 9 similarly between protocols. In TRAD vs. CP, 4 subjects responded more to CP, 1 to TRAD and 10 similarly between protocols. For leg extension 1-RM 2 subjects responded more to DS, 3 to TRAD and 11 similarly between protocols. Additionally, 2 subjects responded more to CP, 2 to TRAD and 11 similarly between protocols. In conclusion, all protocols induced similar individual responses for CSA. For 1-RM, some subjects experience greater gains for the protocol performed with higher loads, such as CP. [ABSTRACT FROM AUTHOR]
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- 2022
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20. Effect of Resistance, Endurance, and Concurrent Training on TNF-α, IL-6, and CRP
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LIBARDI, CLEITON AUGUSTO, DE SOUZA, GIOVANA VERGÍNIA, CAVAGLIERI, CLAUDIA REGINA, MADRUGA, VERA APARECIDA, and CHACON-MIKAHIL, MARA PATRÍCIA TRAINA
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- 2012
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21. The Effect of a Periodized Resistance Training on Inflammatory Markers in Middle-Aged Men: 2090: Board #219 June 3 8:00 AM - 9:30 AM
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Libardi, Cleiton Augusto, Chacon-Mikahil, Mara Patricia Traina, Gáspari, Arthur Fernandes, de Souza, Giovana Verginia, dos Santos, Claudinei Ferreira, Dias, Rodrigo, Frollini, Anelena B., Brunelli, Diego, Cavaglieri, Claudia Regina, and Madruga, Vera Aparecida
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- 2010
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22. Concurrent And Resistance Training: Interleukin-6 And Tumor Necrosis Factor-Alpha Responses In Middle-aged Man: 1385: Board #41 June 2 9:30 AM - 11:00 AM
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Chacon-Mikahil, Mara Patricia Traina, Libardi, Cleiton Augusto, Gáspari, Arthur Fernandes, de Souza, Giovana Verginia, dos Santos, Claudinei Ferreira, Dias, Rodrigo, Frollini, Anelena B., Brunelli, Diego, Cavaglieri, Claudia Regina, and Madruga, Vera Aparecida
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- 2010
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23. Time Course of Skeletal Muscle miRNA Expression after Resistance, High-Intensity Interval, and Concurrent Exercise.
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TELLES, GUILHERME DEFANTE, LIBARDI, CLEITON AUGUSTO, CONCEIÇÃO, MIGUEL SOARES, VECHIN, FELIPE CASSARO, LIXANDRÃO, MANOEL EMÍLIO, LUGNANI DE ANDRADE, ANDRÉ LUÍS, GUEDES, DANIEL NOVAIS, UGRINOWITSCH, CARLOS, and CAMERA, DONNY MICHAEL
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LEG physiology , *RESISTANCE training , *SKELETAL muscle , *BIOPSY , *OXYGEN consumption , *MICRORNA , *RANDOMIZED controlled trials , *EXERCISE , *QUADRICEPS muscle , *MESSENGER RNA , *HIGH-intensity interval training , *STATISTICAL sampling , *CROSSOVER trials , *SPRINTING , *EPIGENOMICS - Abstract
Introduction: Exercise-induced microRNA (miRNA) expression has been implicated in the regulation of skeletal muscle plasticity. However, the specificity and acute time course in miRNA expression after divergent exercisemodes are unknown. In a randomized crossover design, we compared the acute expression profile of eight skeletalmusclemiRNAs previously reported to be involved in skeletalmuscle development, growth, andmaintenance after a bout of either resistance exercise (RE), high-intensity interval exercise (HIIE), and concurrent resistance and high-intensity interval exercises (CE). Methods: Nine untrained youngmen (23.9 ± 2.8 yr, 70.1 ± 14.9 kg, 177.2 ± 3.0 cm, 41.4 ± 5.2mL·kg-1·min-1) underwent a counterbalanced crossover design in which they performed bouts of RE (2 x 10 repetitions maximum 45° leg press and leg extension exercises), HIEE (12 x 1-min sprints at VO2peak with 1-min rest intervals between sprints), and CE (RE followed by HIIE), separated by 1 wk. Vastus lateralis biopsies were harvested immediately before (Pre) and immediately (0 h), 4 h, and 8 h after each exercise bout. Results: There were similar increases (main effect of time; P < 0.05) in miR-1-3p, miR-133a-3p, miR-133b, miR-181a-3p, and miR-486 expression at 8 h from Pre with all exercise modes. Besides a main effect of time, miR-23a-3p and miR-206 presented a main effect of condition with lower expression after HIIE compared with RE and CE. Conclusions: Select miRNAs (miR-1-3p, miR-133a-3p, miR-133b, miR-23a-3p, miR-181a-3p, miR-206, miR-486) do not exhibit an expression specificity in the acute recovery period after a single bout of RE, HIIE, or CE in skeletal muscle. Our data also indicate that RE has a higher effect on the expression of miR-23a-3p and miR-206 than HIIE. As upregulation of these miRNAs seems to be confined to the 8-h period after exercise, this may subsequently affect the expression patterns of target mRNAs forming the basis of exercise-induced adaptive responses. [ABSTRACT FROM AUTHOR]
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- 2021
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24. Maintenance of Muscle Mass and Cardiorespiratory Fitness to Cancer Patients During COVID-19 Era and After SARS-CoV-2 Vaccine.
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Conceição, Miguel S., Derchain, Sophie, Vechin, Felipe Cassaro, Telles, Guilherme, Maginador, Guilherme Fiori, Sarian, Luís Otávio, Libardi, Cleiton Augusto, and Ugrinowitsch, Carlos
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MUSCLE mass ,COVID-19 ,CARDIOPULMONARY fitness ,SARS-CoV-2 ,SOCIAL distancing - Abstract
There is emerging evidence that decreased muscle mass and cardiorespiratory fitness (CRF) are associated with increased risk of cancer-related mortality. This paper aimed to present recommendations to prescribe effective and safe exercise protocols to minimize losses, maintain or even improve muscle mass, strength, and CRF of the cancer patients who are undergoing or beyond treatment during the COVID-19 era. Overall, we recommend performing exercises with bodyweight, elastic bands, or suspension bands to voluntary interruption (i.e., interrupt the exercise set voluntarily, according to their perception of fatigue, before concentric muscular failure) to maintain or increase muscle strength and mass and CRF during COVID-19 physical distancing. Additionally, rest intervals between sets and exercises (i.e., long or short) should favor maintaining exercise intensities between 50 and 80% of maxHR and/or RPE of 12. In an exercise program with these characteristics, the progression of the stimulus must be carried out by increasing exercise complexity, number of sets, and weekly frequency. With feasible exercises attainable anywhere, modulating only the work-to-rest ratio and using voluntary interruption, it is possible to prescribe exercise for a wide range of patients with cancer as well as training goals. Exercise must be encouraged; however, exercise professionals must be aware of the patient's health condition even at a physical distance to provide a safe and efficient exercise program. Exercise professionals should adjust the exercise prescription throughout home confinement whenever necessary, keeping in mind that minimal exercise stimuli are beneficial to patients in poor physical condition. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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25. Effect of Protein and Carbohydrate Combined with Resistance Training on Muscular Adaptation.
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Santos, Priscila Carvalho, Libardi, Cleiton Augusto, Nóbrega, Sanmy Rocha, de Carvalho, Milena Barbon, Galan, Bryan Steve Martinez, and de Freitas, Ellen Cristini
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RESISTANCE training , *PROTEINS , *CONFIDENCE intervals , *HYPERTROPHY , *PHYSIOLOGICAL adaptation , *DIETARY supplements , *CARBOHYDRATES , *MUSCLE strength , *DESCRIPTIVE statistics , *ODDS ratio , *WHEY proteins - Abstract
The purpose was to compare the effects of protein (whey protein) and carbohydrate supplementation and protein alone both combined with resistance training on muscle strength, muscle mass and total training volume progression in untrained young men. Resistance training was performed using the leg press and knee extension until concentric failure (8−12 repetition maximum), three times a week for eight weeks. Muscle strength and muscle cross-sectional area were assessed before and after training. Total training volume progression was calculated considering the first and eighth week. Seventeen men completed the study (protein and carbohydrate, n=9, age 23.44 ± 4.56 years, weight: 62.13±6.17 kg, height: 1.75±0.02 m, body mass index: 20.29±2.08 kg/m2 ; protein, n=8, age 24.63±2.39 years, weight: 69.01±5.57 kg, height: 1.77±0.07 m; body mass index: 21.64±1.05 kg/m2. Both protocols showed similar increases in muscle strength (effect size: protein and carbohydrate=1.28; protein=0.97; p<0.001), muscle cross sectional area (effect size: protein and carbohydrate=0.66; protein=0.47; p<0.001) and total training volume progression (effect size: protein and carbohydrate=2.68; protein=1.63; p<0.001) after training. No differences were found between groups p>0.05). Protein and carbohydrate supplementation combined with resistance training does not induce greater gains in muscle strength, hypertrophy and total training volume compared to resistance training combined with protein alone in untrained individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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26. Response: Commentary: Can Blood Flow Restricted Exercise Cause Muscle Damage? Commentary on Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety.
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Burr, Jamie F., Hughes, Luke, Warmington, Stuart, Scott, Brendan R., Owens, Johnny, Abe, Takashi, Nielsen, Jakob L., Libardi, Cleiton Augusto, Laurentino, Gilberto, Neto, Gabriel Rodrigues, Brandner, Christopher, Martin-Hernandez, Juan, Loenneke, Jeremy, and Patterson, Stephen D.
- Subjects
BLOOD flow ,EXERCISE ,MUSCLES ,EXERCISE physiology ,STRENGTH training - Published
- 2020
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27. Effects of resistance training with controlled versus self-selected repetition duration on muscle mass and strength in untrained men.
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Chaves, Talisson Santos, de Campos Biazon, Thaís Marina Pires, dos Santos, Lucas Marcelino Eder, and Libardi, Cleiton Augusto
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RESISTANCE training ,MUSCLE strength ,SWINDLERS & swindling ,STRENGTH training ,DEPENDENT variables ,MUSCLE mass ,MUSCLE growth - Abstract
The aim of this study was to compare the effect of self-selected repetition duration (SELF), with and without volume load (VL) equalized with controlled repetition duration (CON) on muscle strength and hypertrophy in untrained males. We used a within-subjects design in which 20 volunteers (age: 24.7 ± 2.9 years) had one leg randomly assigned to CON (i.e., 2 s concentric, 2 s eccentric) and the other to SELF or to self-selected repetition duration with equalized volume load (SELF-EV). One repetition maximum (1-RM) and muscle cross-sectional area (CSA) were measured at baseline (Pre) and after (Post) resistance training (RT; 2×/wk for 8 weeks). For the main study variables (1-RM and muscle CSA), a mixed-model analysis was performed, assuming repetition duration (SELF, SELF-EV and CON), and time (Pre and Post) as fixed factors and the subjects as random factor for each dependent variable (1-RM and CSA). All RT protocols showed significant increases in values of 1-RM from Pre (CON: 73.7 ± 17.6 kg; SELF: 75.9 ± 17.7 kg; and SELF-EV: 72.6 ± 16.9 kg) to Post (CON: 83.4 ± 19.9 kg, effect size (ES): 0.47; SELF: 84 ± 19.1 kg, ES: 0.43; and SELF-EV: 83.2 ± 19.9 kg, ES: 0.57, P < 0.0001). Muscle CSA values increased for all protocols from Pre (CON: 12.09 ± 3.14 cm
2 ; SELF: 11.91 ± 3.71 cm2 ; and SELF-EV: 11.93 ± 2.32 cm2 ) to Post (CON: 13.03 ± 3.25 cm2 , ES: 0.29; SELF: 13.2 ± 4.16 cm2 , ES: 0.32; and SELF-EV: 13.2 ± 2.35 cm2 , ES: 0.53, P < 0.0001). No significant differences between protocols were found for both 1-RM and CSA (P > 0.05). Performing RT with SELF, regardless of VL, was equally effective in inducing increases in muscle strength and hypertrophy compared to CON in untrained men. [ABSTRACT FROM AUTHOR]- Published
- 2020
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28. Muscle damage responses to resistance exercise performed with high-load versus low-load associated with partial blood flow restriction in young women.
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Alvarez, Ieda Fernanda, Damas, Felipe, Biazon, Thaís Marina Pires de, Miquelini, Maiara, Doma, Kenji, and Libardi, Cleiton Augusto
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BLOOD flow restriction training ,CROSSOVER trials ,EXERCISE physiology ,MUSCLE contraction ,MUSCLE strength ,MUSCULOSKELETAL system physiology ,MYALGIA ,PHYSICAL therapy ,WOMEN ,COOLDOWN ,RESISTANCE training - Abstract
The aim of this study was to compare if an acute exercise session of high-load resistance training (HL-RT, e.g. 70% of 1 repetition-maximum, 1 RM) induces a higher magnitude of muscle damage compared with a RT protocol with low-loads (e.g. 20% 1 RM) associated with partial blood flow restriction (LL-BFR), and investigate the recovery in the days after the protocols. We used an unilateral crossover research design in which 10 young women (22(2) y; 162(5) cm; 66(11) kg) performed HL-RT and LL-BFR in a randomized, counterbalanced manner with a minimum interval of 2 weeks between protocols. Indirect muscle damage markers were evaluated before and once a day for 4 days into recovery. Main results showed decreases of 8–12% at 24–48 h in maximal voluntary isometric and concentric contraction torques (P < 0.03), and changes in muscle architecture markers (P < 0.03) for HL-RT and LL-BFR, with no differences between protocols (P > 0.05). Moreover, delayed onset muscle soreness increased only after LL-BFR (P < 0.001). We conclude that an acute bout of low volume HL-RT or LL-BFR to failure resulted in edema-induced muscle swelling, but do not induce major or long-lasting decrements in muscle function and the level of soreness promoted from LL-BFR was mild. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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29. Suspension Training: A New Approach to Improve Muscle Strength, Mass, and Functional Performances in Older Adults?
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Angleri, Vitor, Soligon, Samuel Domingos, da Silva, Deivid Gomes, Bergamasco, João Guilherme Almeida, and Libardi, Cleiton Augusto
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MUSCLE strength ,OLDER people ,MOBILITY of older people ,EXERCISE physiology ,STRENGTH training ,SPORTS sciences - Published
- 2020
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30. Erratum to: Effects of eccentric exercise on systemic concentrations of pro- and anti-inflammatory cytokines and prostaglandin (E2): comparison between young and postmenopausal women
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Conceição, Miguel Soares, Libardi, Cleiton Augusto, Nogueira, Felipe Romano Damas, Bonganha, Valéria, Gáspari, Arthur Fernandes, Chacon-Mikahil, Mara Patrícia Traina, Cavaglieri, Cláudia Regina, and Madruga, Vera Aparecida
- Published
- 2012
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31. Effect of individualized resistance training prescription with heart rate variability on individual muscle hypertrophy and strength responses.
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De Oliveira, Ramon Martins, Ugrinowitsch, Carlos, Kingsley, James Derek, Da Silva, Deivid Gomes, Bittencourt, Diego, Caruso, Flávia Rossi, Borghi-Silva, Audrey, and Libardi, Cleiton Augusto
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AUTONOMIC nervous system physiology ,QUADRICEPS muscle physiology ,PHYSIOLOGICAL adaptation ,HEART beat ,MUSCLE strength ,MUSCLE strength testing ,STATISTICAL sampling ,QUADRICEPS muscle ,COOLDOWN ,RANDOMIZED controlled trials ,PRE-tests & post-tests ,MUSCULAR hypertrophy ,RESISTANCE training - Abstract
The aim of the present study was to investigate if resistance training (RT), performed with individualized recovery between sessions (RT-IND), promotes greater gains in strength and muscle mass and reduces the variability on adaptations compared to RT with fixed recovery intervals (RT-FIX). Twenty young men (age 21.9 ± 3.3 years) were randomized in the RT-IND and RT-FIX groups. Five days before the beginning of the training, measurements of the root mean square of successive R-R intervals differences (RMSSD) values of each individual were performed to establish the baseline values. Before each RT session, the RMSSD values determined whether the participants from RT-IND protocol were recovered from the previous session. Participants performed the RT session only if RMSSD values had returned to the baseline, otherwise they had to wait for an additional 24 h. RT-FIX performed an RT session every 48 h. Muscle strength was measured by one-maximal repetition (1-RM) test and muscle cross-section area (CSA) of the vastus laterals by ultrasonography were assessed pre- and post-training. 1-RM values increased significantly from pre to post-training for both groups (RT-IND: 30% and RT-FIX: 42%, main time effect, P < 0001), with no significant difference between groups. Muscle CSA increased significantly from pre to post-training (RT-IND: 15.7% and RT-FIX: 15.8%, main time effect, P < 0001), with no significant difference between groups. In conclusion, RT-IND did not increase the gains in muscle strength and mass neither reduce the variability in muscle adaptations when compared to the RT-FIX. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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32. Blood Flow Restriction Exercise Position Stand: Considerations of Methodology, Application, and Safety.
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Patterson, Stephen D., Hughes, Luke, Warmington, Stuart, Burr, Jamie, Scott, Brendan R., Owens, Johnny, Abe, Takashi, Nielsen, Jakob L., Libardi, Cleiton Augusto, Laurentino, Gilberto, Neto, Gabriel Rodrigues, Brandner, Christopher, Martin-Hernandez, Juan, and Loenneke, Jeremy
- Subjects
AEROBIC exercises ,BLOOD flow ,MUSCULAR hypertrophy ,MUSCLE strength ,SPORTS medicine - Abstract
The current manuscript sets out a position stand for blood flow restriction (BFR) exercise, focusing on the methodology, application and safety of this mode of training. With the emergence of this technique and the wide variety of applications within the literature, the aim of this position stand is to set out a current research informed guide to BFR training to practitioners. This covers the use of BFR to enhance muscular strength and hypertrophy via training with resistance and aerobic exercise and preventing muscle atrophy using the technique passively. The authorship team for this article was selected from the researchers focused in BFR training research with expertise in exercise science, strength and conditioning and sports medicine. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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33. High-frequency resistance training does not promote greater muscular adaptations compared to low frequencies in young untrained men.
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Barcelos, Cintia, Damas, Felipe, Nóbrega, Sanmy Rocha, Ugrinowitsch, Carlos, Lixandrão, Manoel Emílio, Marcelino Eder Dos Santos, Lucas, and Libardi, Cleiton Augusto
- Subjects
EXERCISE physiology ,MUSCLE strength ,STATISTICAL sampling ,EFFECT sizes (Statistics) ,MUSCULAR hypertrophy ,RESISTANCE training - Abstract
The aim of the study was to compare the effect of resistance training (RT) frequencies of five times (RT5), thrice- (RT3) or twice- (RT2) weekly in muscle strength and hypertrophy in young men. Were used a within-subjects design in which 20 participants had one leg randomly assigned to RT5 and the other to RT3 or to RT2. 1 RM and muscle cross-sectional area (CSA) were assessed at baseline, after four (W4) and eight (W8) RT weeks. RT5 resulted in greater total training volume (TTV) than RT3 and RT2 (P = .001). 1 RM increased similarly between protocols at W4 (RT5: 55 ± 9 Kg, effect size (ES): 1.18; RT3: 51 ± 11 Kg, ES: 0.80; RT2: 54 ± 7 Kg, ES: 1.13; P < .0001) and W8 (RT5: 62 ± 11 Kg, ES: 1.81; RT3: 57 ± 11 Kg, ES: 1.40; RT2: 60 ± 8 Kg, ES: 1.98; P < .0001) vs. baseline (RT5: 45 ± 9 Kg; RT3: 42 ± 11 Kg; RT2: 46 ± 7 Kg). CSA increased similarly between protocols at W4 (RT5: 24.6 ± 3.9 cm
2 , ES: 0.54; RT3: 22.0 ± 4.6 cm2 , ES: 0.19; RT2: ES: 0.25; 23.8 ± 3.8 cm2 ; P < .001), and W8 (RT5: 25.3 ± 4.3 cm2 ; ES: 0.69; RT3: 23.6 ± 4.2 cm2 , ES: 0.58; RT2: 25.5 ± 3.7 cm2 ; ES: 0.70; P < .0001) vs. baseline (RT5: 22.5 ± 3.8 cm2 ; RT3: 21.2 ± 4.0 cm2 ; RT2: 22.9 ± 3.8 cm2 ). Performing RT5, RT3 and RT2 a week result in similar muscle strength increase and hypertrophy, despite higher TTV for RT5. [ABSTRACT FROM AUTHOR]- Published
- 2018
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34. Self-selected vs. Fixed Repetition Duration: Effects on Number of Repetitions and Muscle Activation in Resistance-Trained Men.
- Author
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Nóbrega, Sanmy Rocha, Barroso, Renato, Ugrinowitsch, Carlos, da Costa, Jean Lucas Fernandes, Alvarez, Ieda Fernanda, Barcelos, Cintia, and Libardi, Cleiton Augusto
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QUADRICEPS muscle physiology ,SKELETAL muscle physiology ,EXERCISE physiology ,MUSCLE contraction ,RANDOMIZED controlled trials ,EXERCISE intensity ,RESISTANCE training - Abstract
Nóbrega, SR, Barroso, R, Ugrinowitsch, C, da Costa, JLF, Alvarez, IF, Barcelos, C, and Libardi, CA. Self-selected vs. fixed repetition duration: effects on number of repetitions and muscle activation in resistance-trained men. J Strength Cond Res 32(9): 2419–2424, 2018—The aim of this study was to compare the effects of self-selected and fixed repetition duration (RD) on resistance exercise (RE) volume, muscle activation, and time under tension (TUT) per repetition and per session. Twelve resistance-trained men participated in the study. A randomized cross-over design was used and each participant performed 2 high-intensity RE protocols in a balanced order: (a) 3 sets of RE with self-selected RD (SELF); and (b) 3 sets of RE with fixed RD (2-second concentric and 2-second eccentric [FIX]). Muscle activation was assessed through surface electromyography (EMG) of the vastus lateralis and vastus medialis throughout RE sessions. Overall, RE volume was significantly greater for SELF (p = 0.01), whereas TUT per repetition was significantly greater for FIX (p = 0.0001). No significant differences between protocols were detected for TUT per session. Between-protocol comparisons revealed significantly greater EMG amplitude for SELF compared with FIX at S1 (p = 0.01), S2 (p = 0.03), and S3 (p = 0.03). Both SELF and FIX protocols produced significant increases in EMG amplitude from 25 to 100% (p < 0.001) of set completion. Between-protocol comparisons revealed significantly greater EMG amplitude for SELF compared with FIX at 75% (p = 0.03) and 100% (p = 0.01). In conclusion, self-selected RD resulted in greater volume and muscle activation compared with fixed RD in an RE session. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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35. Effects of inspiratory muscle training in professional women football players: a randomized sham-controlled trial.
- Author
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Archiza, Bruno, Andaku, Daniela Kuguimoto, Caruso, Flávia Cristina Rossi, Bonjorno, José Carlos, Oliveira, Cláudio Ricardo de, Ricci, Paula Angélica, Amaral, André Capaldo do, Mattiello, Stela Márcia, Libardi, Cleiton Augusto, Phillips, Shane A., Arena, Ross, and Borghi-Silva, Audrey
- Subjects
BREATHING exercises ,FOOTBALL ,HEMOGLOBINS ,INTERCOSTAL muscles ,MUSCLES ,NEAR infrared spectroscopy ,SPORTS ,WOMEN athletes ,QUADRICEPS muscle ,EXERCISE tolerance - Abstract
This study was conducted to determine the effects of inspiratory muscle training (IMT) on respiratory and peripheral muscles oxygenation during a maximal exercise tolerance test and on repeated-sprint ability (RSA) performance in professional women football players. Eighteen athletes were randomly assigned to one of the following groups: SHAM (n = 8) or IMT (n = 10). After a maximal incremental exercise test, all participants performed (on a different day) a time-to-exhaustion (Tlim) test. Peripheral and respiratory muscles oxygenation by near-infrared spectroscopy, breath-by-breath ventilatory and metabolic variables, and blood lactate concentration were measured. The RSA test was performed on a grass field. After a 6 week intervention, all athletes were reevaluated. Both groups showed increases in inspiratory muscles strength, exercise tolerance and RSA performance, however only the IMT group presented lower deoxyhemoglobin and total hemoglobin blood concentrations on intercostal muscles concomitantly to an increased oxyhemoglobin and total hemoglobin blood concentrations on vastus lateralis muscle during Tlim. In conclusion, these results may indicate the potential role of IMT to attenuate inspiratory muscles metaboreflex and consequently improve oxygen and blood supply to limb muscles during high-intensity exercise, with a potential impact on inspiratory muscle strength, exercise tolerance and sprints performance in professional women football players. [ABSTRACT FROM PUBLISHER]
- Published
- 2018
- Full Text
- View/download PDF
36. Concurrent Training with Blood Flow Restriction does not Decrease Inflammatory Markers.
- Author
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Mattos Frota de Souza, Thiago, Libardi, Cleiton Augusto, Cavaglieri, Cláudia Regina, Fernandes Gáspari, Arthur, Brunelli, Diego Trevisan, de Souza, Giovana Vergínia, Ugrinowitsch, Carlos, Li Min Li, and Chacon-Mikahil, Mara Patricia Traina
- Subjects
- *
AGING , *BIOMARKERS , *BLOOD circulation , *C-reactive protein , *INFLAMMATION , *INTERLEUKINS , *PROBABILITY theory , *TUMOR necrosis factors , *BLOOD pressure testing machines , *DATA analysis software , *DESCRIPTIVE statistics , *RESISTANCE training , *CARDIOPULMONARY fitness - Abstract
The aging process is associated with several changes in the elderly such as the decrease in cardiorespiratory fitness, strength and muscle mass, in addition to chronic low-grade inflammation. Concurrent training with blood flow restriction can be an interesting alternative to improve functional capacity with low mechanical stress in the elderly. The purpose of this study was to compare the inflammatory effects in older individuals submitted to two different protocols of concurrent training. Twenty-two healthy older adults (63.7 ± 3.8 years; 69.8 ± 8.9 kg; 1.6 ± 0.1 m) performed 12 weeks of concurrent training (CT) or concurrent training with blood flow restriction (CTBFR) and the effects on inflammatory markers were analyzed. We found inflammatory behavior for the CTBFR group with a significant difference in serum concentration of C-reactive protein between pre- and post-moment (0.96 ± 0.37 to 1.71 ± 1.45, p = 0.049), with no difference between groups, and a time effect in interleukin-6 (pre = 0.86 ± 0.43; post = 1.02 ± 0.46, p = 0.016). We conclude that the CTBFR showed a pro-inflammatory profile after the period of intervention whereas the CT showed the opposite. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
37. Combined training, FNDC5/irisin levels and metabolic markers in obese men: A randomised controlled trial.
- Author
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Bonfante, Ivan Luiz Padilha, Chacon-Mikahil, Mara Patrícia Traina, Brunelli, Diego Trevisan, Gáspari, Arthur Fernandes, Duft, Renata Garbellini, Lopes, Wendell Arhur, Bonganha, Valéria, Libardi, Cleiton Augusto, and Cavaglieri, Cláudia Regina
- Subjects
AEROBIC exercises ,BIOMARKERS ,STATISTICAL correlation ,INSULIN resistance ,METABOLISM ,OBESITY ,PHYSICAL fitness ,RANDOMIZED controlled trials - Abstract
The effects of training on FNDC5/irisin and its association with fitness and metabolic marker improvements induced by training have been poorly investigated in humans. Thus, the present study assessed the effects of combined training (CT) on FNDC5/irisin levels, metabolic markers and fitness adaptations in obese men. Middle-age obese men (age 49.13 ± 5.75, body mass index (BMI) 30.86 ± 1.63) were randomly distributed in the CT group (n = 12) and control group (CGn = 10). The CT consisted of strength followed by aerobic training, 3 times/week, for 24 weeks. Body composition, physical fitness, plasma FNDC5/irisin, biochemical markers and metabolic scores/index were evaluated. CT maintained FNDC5/irisin levels (µg/mL) (pre: 4.15 ± 0.32, post: 4.21 ± 0.32;p = .96) and improved body composition, metabolic and physical fitness markers. In the CG, decreased FNDC5/irisin (µg/mL) (pre: 4.36 ± 0.23, post: 3.57 ± 0.94;p = .01) and reduced strength (supine exercise/kg) (pre: 71 ± 14.7, post: 60.1 ± 14.05;p < .01) were observed, along with a trend to increase HOMA-IR (pre: 2.63 ± 1.11, post: 3.14 ± 1.27;p = .07) and other indicators of metabolic deterioration. An inverse correlation was found between the change (Δ%) in levels of FNDC5/irisin and Δ% glucose, Δ% total cholesterol, Δ% triglycerides and Δ% waist circumference, in addition to a positive relation with Δ% muscle strength. In conclusion, CT maintained FNDC5/irisin levels and provided metabolic and fitness benefits. The correlation between FNDC5/irisin changes and metabolic parameters, as well as the FNDC5/irisin reduction associated with fitness and metabolic worsening in the CG, suggests a relationship between FNDC5/irisin and a healthy metabolic status in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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- View/download PDF
38. Attenuated PGC-α Isoforms following Endurance Exercise with Blood Flow Restriction.
- Author
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SOARES CONCEIÇÃO, MIGUEL, CHACON-MIKAHIL, MARA PATRICIA TRAINA, DEFANTE TELLES, GUILHERME, LIBARDI, CLEITON AUGUSTO, MENDES JÚNIOR, EDSON MANOEL, CASSARO VECHIN, FELIPE, LUGNANI DE ANDRADE, ANDRÉ LUÍS, FERNANDES GÁSPARI, ARTHUR, CHAKUR BRUM, PATRÍCIA, CAVAGLIERI, CLÁUDIA REGINA, SERAG, SARA, SPIEGELMAN, BRUCE M., HAWLEY, JOHN A., and CAMERA, DONNY M.
- Published
- 2016
- Full Text
- View/download PDF
39. The number of sessions required to stabilize peak torque and rate of torque development in isometric contractions in young, middle-age and older individuals.
- Author
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Libardi, Cleiton Augusto, Frota Souza, Thiago Mattos, Conceição, Miguel Soares, Traina Chacon-Mikahil, Mara Patricia, Ugrinowitsch, Carlos, Bonganha, Valéria, Fazolin, Marcio Franco, de Moraes, Antonio Carlos, and Cavaglieri, Cláudia Regina
- Subjects
- *
AGE distribution , *ANALYSIS of variance , *EXERCISE physiology , *EXERCISE tests , *MUSCLE contraction , *PROBABILITY theory , *STATISTICS , *TORQUE , *DATA analysis , *BODY mass index - Abstract
BACKGROUND AND OBJECTIVE: Maximal voluntary isometric contraction (MVIC) is used to determine both peak torque (PT) and rate of torque development (RTD). Familiarization sessions are usually performed to stabilize PT and RTD when performing MVIC. However, it is not clear how many familiarization sessions are required to achieve such stability in different age groups. METHODS: Thirty-three healthy individuals were divided into three groups: young group (YG; 5 men and 7 women, age 22.75 ± 4.53 years), middle-aged group (MAG; 6 men and 5 women, age 50.45 ± 6.12 years) and elderly group (EG; 6 men and 4 women, age 67.80 ± 7.28 years). Individuals performed the MVICs using an isokinetic dynamometer, in four different occasions separated by at least 72 hours. RESULTS: There were no differences in PT and RTD between familiarization sessions for all age groups (P >0.05). CONCLUSIONS: Our findings suggest that the present protocol of MVIC is capable of stabilizing PT and RTD in the first testing session in young, middle-aged and elderly groups. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
40. Habitual physical activity is not associated with lower cardiovascular risk profile or higher aerobic fitness.
- Author
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Fabrício Valério, Denis, Fernandes Gáspari, Arthur, de Souza, Giovana Vergínea, Libardi, Cleiton Augusto, Cavaglieri, Claudia Regina, and Chacon-Mikahil, Mara Patrícia Traina
- Subjects
ANTHROPOMETRY ,CARDIOVASCULAR diseases risk factors ,PHYSICAL fitness ,PROBABILITY theory ,QUESTIONNAIRES ,AEROBIC capacity ,OXYGEN consumption ,PHYSICAL activity ,DESCRIPTIVE statistics ,ONE-way analysis of variance ,MIDDLE age - Abstract
Introduction: Physical inactivity is considered as one of the factors to increase the risk of developing cardiovascular diseases (CVDs) and decrease aerobic fitness mainly in middle-age. Increased habitual physical activity (HPA) is one of the strategies recommended to reduce physical inactivity. However, it is not known whether middle-age individuals who exclusively perform greater amount of HPA have greater aerobic fitness and / or a lower risk of CVDs. Objective: Verify the association between HPA with the risk of CVDs and aerobic fitness in individuals who only perform HPA. Method: We selected 89 male volunteers, age: 47.4 ± 5.06 years, who did not practice systemized physical training. Our measurements were: HPA by the International Physical Activity Questionnaire and Baecke questionnaires, the aerobic fitness by direct assessment of maximal oxygen consumption (VO
2 máx) and the risk of developing cardiovascular disease by the score calculation of General Cardiovascular Risk Profile from Framingham Study. Results: There was no correlation of the HPA level with cardiovascular risk factors, general cardiovascular disease risk and VO2 máx. Moreover, no difference was found between the categorical groups of the IPAQ questionnaire and between the groups, "clusters", calculated from the Baecke questionnaire scores for the variables of cardiovascular risk, general cardiovascular disease risk and VO2máx. Conclusion: This study have found that the HPA level of middle-aged men is not associated with lower cardiovascular risk profile or higher aerobic fitness, suggesting that only increase HPA may not be enough to promote beneficial adaptations in aerobic fitness and improve risk profile for CVDs. These results may be related to low volume and intensity of HPA, which reinforces the importance of performing physical training with control of these variables for health promotion. [ABSTRACT FROM AUTHOR]- Published
- 2016
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- View/download PDF
41. DOR MUSCULAR E ATIVIDADE DE CREATINA QUINASE APÓS AÇÕES EXCÊNTRICAS: UMA ANÁLISE DE CLUSTER.
- Author
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Damas Nogueira, Felipe Romano, Traina Chacon-Mikahil, Mara Patricia, Cassaro Vechin, Felipe, de Barros Berton, Ricardo Paes, Cavaglieri, Claudia Regina, and Libardi, Cleiton Augusto
- Published
- 2014
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- View/download PDF
42. EFEITO DE DIFERENTES MÉTODOS DE RECUPERAÇÃO SOBRE A REMOÇÃO DE LACTATO E DESEMPENHO ANAERÓBIO DE FUTEBOLISTAS.
- Author
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Gustavo Ferrari, Homero, Oliveira, Ramon, Vinicius Strapasson, Marcos, Rodrigues Santa Cruz, Ricardo Alexandre, Libardi, Cleiton Augusto, and Cavaglieri, Claudia Regina
- Subjects
ACTIVE recovery ,SOCCER players ,AEROBIC capacity ,LACTATES ,PHYSICAL training & conditioning ,PHYSICAL therapy - Abstract
The article presents a study which investigates the effect of different recovery methods on soccer players' lactate removal and anaerobic performance. The study compares the active recovery (RA), passive recovery (RP) and ice recovery (RG) and used critical speed to assess the aerobic capacity. The study concluded that the three recovery methods are affective to maintain soccer players' anaerobic performance.
- Published
- 2013
- Full Text
- View/download PDF
43. Sixteen weeks of resistance training can decrease the risk of metabolic syndrome in healthy postmenopausal women.
- Author
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Conceição, Miguel Soares, Bonganha, Valéria, Vechin, Felipe Cassaro, Berton, Ricardo Paes de Barros, Lixandrão, Manoel Emílio, Nogueira, Felipe Romano Damas, de Souza, Giovana Vergínia, Chacon-Mikahil, Mara Patricia Traina, and Libardi, Cleiton Augusto
- Subjects
RESISTANCE training ,METABOLIC syndrome ,POSTMENOPAUSE ,CONTROL groups ,HIGH density lipoproteins - Abstract
Background: The postmenopausal phase has been considered an aggravating factor for developing metabolic syndrome. Notwithstanding, no studies have as yet investigated the effects of resistance training on metabolic syndrome in postmenopausal women. Thus, the purpose of this study was to verify whether resistance training could reduce the risk of metabolic syndrome in postmenopausal women. Methods: Twenty postmenopausal women were randomly assigned to a resistance training protocol (n = 10, 53.40 ± 3.95 years, 64.58 ± 9.22 kg) or a control group (n = 10, 53.0 ± 5.7 years, 64.03 ± 5.03 kg). In the resistance training protocol, ten exercises were performed, with 3 ? 8?10 maximal repetitions three times per week, and the load was increased every week. Two-way analysis of variance was used to evaluate specific metabolic syndrome Z-score, high density lipoprotein cholesterol, fasting blood glucose, triglycerides, waist circumference, blood pressure, strength, and body composition. The level of statistical significance was set at P < 0.05. Results: The main results demonstrated a significant decrease of metabolic syndrome Z-score when the postmenopausal women performed resistance training (P = 0.0162). Moreover, we observed decreases in fasting blood glucose for the resistance training group (P = 0.001), and also significant improvements in lean body mass (P = 0.042, 2.46%), reduction of body fat percentage (P = 0.001, -6.75%) and noticeable increases in muscle strength after resistance training to leg press (P = 0.004, 41.29%) and bench press (P = 0.0001, 27.23%). Conclusion: It was concluded that resistance training performed three times a week may reduce the metabolic syndrome Z-score with concomitant decreases in fasting blood glucose, improvements in body composition, and muscle strength in postmenopausal women. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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44. Comparison of maximal muscle strength of elbow flexors and knee extensors between younger and older men with the same level of daily activity.
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Nogueira, Felipe Romano Damas, Libardi, Cleiton Augusto, Vechin, Felipe Cassaro, Lixandrão, Manoel Emílio, de Barros Berton, Ricardo Paes, de Souza, Thiago Mattos Frota, Conceição, Miguel Soares, Cavaglieri, Claudia Regina, and Chacon-Mikahil, Mara Patricia Traina
- Subjects
PHYSICAL fitness ,MUSCLE strength ,EXERCISE ,DEVELOPMENTAL biology ,AGING - Abstract
Background: Aging promotes neuromuscular loss, significantly reducing muscle strength. The magnitude of loss of strength seems to be different between the limbs, probably because of differences in activities of daily living (ADL). Therefore, the present study compared the muscle strength of the elbow flexors and knee extensors in younger (n = 7, mean age 23.3 ± 1.2 years) and older (n = 5, mean age 61.8 ± 2.6 years) men matched by ADL level. Methods: The study participants performed maximal concentric, isometric, and eccentric contractions of the elbow flexors and knee extensors using an isokinetic dynamometer following a crossover study design. Changes in the dependent variables were compared using mixed model analysis (limb versus age). Results: The main results demonstrated that concentric, eccentric, and mean contraction torques for knee extensors were significantly (P < 0.05) higher for younger men than for elderly men. On the other hand, no statistically significant difference (P > 0.05) was found in concentric, isometric, eccentric, and mean torques for elbow flexors between younger and older individuals. Conclusion: These results show that elbow flexors maintain better strength than knee extensors through aging, even when comparing individuals with similar ADL levels. [ABSTRACT FROM AUTHOR]
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- 2013
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45. The effect of eccentric contraction velocity on muscle damage: A review.
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Nogueira, Felipe Romano Damas, Conceição, Miguel Soares, Vechin, Felipe Cassaro, Junior, Edson Manoel Mendes, Rodrigues, Guilherme Fernando Couto, Fazolin, Marcio Aparecido, Chacon-Mikahil, Mara Patricia Traina, and Libardi, Cleiton Augusto
- Abstract
The velocity at which eccentric exercise is performed may be a factor in the extent of muscular damage. However, studies differ regarding the exercise velocity that promotes greater muscle damage. The purpose of this review was to analyze studies that looked into at least two different eccentric exercise velocities and verified markers of muscle damage. Relevant studies for this review were identified and the methodological quality of each study was calculated based on the Physiotherapy Evidence Database (PEDro) scale. Twelve studies were included herein. The mean PEDro rating was 6.67, ranging from 5 to 7. Seven studies reported that the faster eccentric exercise velocity induced greater muscle damage. Four studies showed no differences between velocities and a single study has indicated a greater magnitude of muscle damage after slow eccentric exercise. Therefore, it seems that fast eccentric exercise may indeed be associated with greater muscle damage even though exercise velocity per se is not the main factor involved in eccentric exercise-induced muscle damage in both animal and human models. [ABSTRACT FROM AUTHOR]
- Published
- 2013
46. Effect of Resistance, Endurance, and Concurrent Training on TNF-a, IL-6, and CRP.
- Author
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LIBARDI, CLEITON AUGUSTO, DE SOUZA, GIOVANA VERGINÍA, CAVAGLIERI, CLAUDIA REGINA, MADRUGA, VERA APARECIDA, and CHACON-MIKAHIL, MARA PATRICÍA TRAINA
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- *
ANALYSIS of variance , *C-reactive protein , *ENZYME-linked immunosorbent assay , *EXERCISE , *INFLAMMATION , *INTERLEUKINS , *LIPIDS , *MUSCLE strength , *PHYSICAL fitness , *RESEARCH funding , *STATISTICS , *TUMOR necrosis factors , *STATISTICAL power analysis , *DATA analysis , *AEROBIC capacity , *PHYSICAL training & conditioning , *REPEATED measures design , *OXYGEN consumption , *SEDENTARY lifestyles , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
The article reports on research which was conducted to evaluate the effects 16 weeks of resistance training (RT), endurance training (ET) and concurrent training (CT) had on inflammatory markers, C-reactive protein (CRP), and functional capacity in sedentary middle-age men. Researchers evaluated 47 men who performed three weekly sessions lasting about 60 minutes for 16 weeks. They found that 16 weeks of RT, ET, or CT in middle-age healthy men did not effect low and moderate IL-6, TNF-a, and CRP levels but that CT performed in the same weekly frequency and session duration of ET and RT was effective in increasing both maximal strength and oxygen uptake peak, in addition to fostering improvements in lipid profile.
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- 2012
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47. Application of Artificial Intelligence to Automate the Reconstruction of Muscle Cross-Sectional Area Obtained by Ultrasound.
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DA Silva DG, DA Silva DG, Angleri V, Scarpelli MC, Bergamasco JGA, Nóbrega SR, Damas F, Chaves TS, Camargo HA, Ugrinowitsch C, and Libardi CA
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- Humans, Male, Adult, Image Processing, Computer-Assisted methods, Neural Networks, Computer, Young Adult, Reproducibility of Results, Ultrasonography methods, Quadriceps Muscle diagnostic imaging, Quadriceps Muscle anatomy & histology, Artificial Intelligence, Magnetic Resonance Imaging methods
- Abstract
Purpose: Manual reconstruction (MR) of the vastus lateralis (VL) muscle cross-sectional area (CSA) from sequential ultrasound (US) images is accessible, is reproducible, and has concurrent validity with magnetic resonance imaging. However, this technique requires numerous controls and procedures during image acquisition and reconstruction, making it laborious and time-consuming. The aim of this study was to determine the concurrent validity of VL CSA assessments between MR and computer vision-based automated reconstruction (AR) of CSA from sequential images of the VL obtained by US., Methods: The images from each sequence were manually rotated to align the fascia between images and thus visualize the VL CSA. For the AR, an artificial neural network model was utilized to segment areas of interest in the image, such as skin, fascia, deep aponeurosis, and femur. This segmentation was crucial to impose necessary constraints for the main assembly phase. At this stage, an image registration application, combined with differential evolution, was employed to achieve appropriate adjustments between the images. Next, the VL CSA obtained from the MR ( n = 488) and AR ( n = 488) techniques was used to determine their concurrent validity., Results: Our findings demonstrated a low coefficient of variation (CV) (1.51%) for AR compared with MR. The Bland-Altman plot showed low bias and close limits of agreement (+1.18 cm 2 , -1.19 cm 2 ), containing more than 95% of the data points., Conclusions: The AR technique is valid compared with MR when measuring VL CSA in a heterogeneous sample., (Copyright © 2024 by the American College of Sports Medicine.)
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- 2024
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48. Resistance Training With Partial Blood Flow Restriction in a 99-Year-Old Individual: A Case Report.
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Scarpelli MC, Bergamasco JGA, Arruda EAB, Cook SB, and Libardi CA
- Abstract
In aging populations for which the use of high loads is contraindicated, low load resistance training associated with blood flow restriction (RT-BFR) is an alternative strategy to induce muscle mass gains. This study investigates the effects of RT-BFR on muscle mass, muscle function, and quality of life of a 99-year-old patient with knee osteoarthritis and advanced muscle mass deterioration. Training protocol consisted of 24 sessions of a unilateral free-weight knee extension exercise associated with partial blood flow restriction through a manometer cuff set at 50% of complete vascular occlusion pressure. We evaluated: cross-sectional area (CSA) and thickness (MT) of the vastus lateralis muscle by ultrasound; function through the Timed Up and Go (TUG) test; and quality of life (QoL) by the WHOQOL-bref, WHOQOL-OLD and WOMAC questionnaires. All tests were performed prior to the training period (Pre) and after the 12th (Mid) and 24th (Post) sessions. Changes were considered significant if higher than 2 times the measurement's coefficient of variation (CV). After 24 sessions, there was an increase of 12% in CSA and 8% in MT. Questionnaires scores and TUG values worsened from Pre to Mid and returned in Post. We consider RT-BFR a viable and effective strategy to promote muscle mass gains in nonagenarians and delay the decline in functionality and QoL associated with aging., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Scarpelli, Bergamasco, Arruda, Cook and Libardi.)
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- 2021
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49. Corrigendum: Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety.
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Patterson SD, Hughes L, Warmington S, Burr J, Scott BR, Owens J, Abe T, Nielsen JL, Libardi CA, Laurentino G, Neto GR, Brandner C, Martin-Hernandez J, and Loenneke J
- Abstract
[This corrects the article DOI: 10.3389/fphys.2019.00533.]., (Copyright © 2019 Patterson, Hughes, Warmington, Burr, Scott, Owens, Abe, Nielsen, Libardi, Laurentino, Neto, Brandner, Martin-Hernandez and Loenneke.)
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- 2019
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50. Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety.
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Patterson SD, Hughes L, Warmington S, Burr J, Scott BR, Owens J, Abe T, Nielsen JL, Libardi CA, Laurentino G, Neto GR, Brandner C, Martin-Hernandez J, and Loenneke J
- Abstract
The current manuscript sets out a position stand for blood flow restriction (BFR) exercise, focusing on the methodology, application and safety of this mode of training. With the emergence of this technique and the wide variety of applications within the literature, the aim of this position stand is to set out a current research informed guide to BFR training to practitioners. This covers the use of BFR to enhance muscular strength and hypertrophy via training with resistance and aerobic exercise and preventing muscle atrophy using the technique passively. The authorship team for this article was selected from the researchers focused in BFR training research with expertise in exercise science, strength and conditioning and sports medicine.
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- 2019
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