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Human infants have remarkable abilities to reason about the underlying and invisible causes that drive others' actions. These abilities are at the core of human social cognition throughout life. Artificial Intelligence (AI) systems continue to fall short in achieving this same commonsense social knowledge. Recent benchmarks focusing on social cognition and theory of mind have begun to address the gap between human and machine social intelligence, but they do not fully consider the social reasoning required to understand scenarios with multiple interacting agents. Building on such benchmarks, we present eight new tasks focusing on different early social competencies, as informed by behavioral experiments with infants. We use a self-supervised Transformer model as a baseline test of our new tasks, and in addition, we evaluate this model on a previous social-cognitive benchmark. While our model shows improved performance on the previous benchmark compared with other data-driven models, it performs sub-optimally on our new tasks, revealing the challenge of learning complex social interactions through visual data alone.

In order to systematically study the water environment problems of coal mine, we study and conclude the destruction mechanism and characteristics of coal mining on the water environment of coal mine by statistics on the water environment problems in 104 mining areas with 14 large coal bases, based on the hydro-geological structure of mining areas, water resources loss and water environmental pollution. The paper divides water environmental problems of coal mines into six types, and on the basis of this, we analyze the distribution and characteristics of water environmental problems of various kinds of coal mines. In order to provide scientific theoretical basis for the safe and green mining of coal mine, we construct the water environment management mode of coal mine and combine several treatment technologies to deal with various water environment problems of coal mine with different characteristics in essence.

Ubiquitination plays an essential role in protein stability, subcellular localization, and interactions. Crosstalk between different types of ubiquitination results in distinct biological outcomes for proteins. However, the role of ubiquitinationrelated crosstalk in lymph node (LN) metastasis and the key regulatory factors controlling this process have not been determined. Using high-throughput sequencing, we found that ubiquitin-conjugating enzyme E2 C (UBE2C) was overexpressed in bladder cancer (BCa) and was strongly associated with an unfavorable prognosis. Overexpression of UBE2C increased BCa lymphangiogenesis and promoted LN metastasis both in vitro and in vivo. Mechanistically, UBE2C mediated sodium-coupled neutral amino acid transporter 2 (SNAT2) monoubiquitination at lysine 59 to inhibit K63-linked polyubiquitination at lysine 33 of SNAT2. Crosstalk between monoubiquitination and K63-linked polyubiquitination increased SNAT2 membrane protein levels by suppressing epsin 1-mediated (EPN1-mediated) endocytosis. SNAT2 facilitated glutamine uptake and metabolism to promote VEGFC secretion, ultimately leading to lymphangiogenesis and LN metastasis in patients with BCa. Importantly, inhibition of UBE2C significantly attenuated BCa lymphangiogenesis in a patient-derived xenograft model. Our results reveal the mechanism by which UBE2C mediates crosstalk between the monoubiquitination and K63-linked polyubiquitination of SNAT2 to promote BCa metastasis and identify UBE2C as a promising target for treating LN-metastatic BCa., Introduction Lymph node (LN) metastasis is the predominant route of metastasis for most solid tumors and promotes distant metastasis (1, 2). Patients with LN involvement have shorter distant metastasis-free survival [...]

Objective The Haopinggou Ag-Au polymetallic deposit is a typical intermediate-sulfidation epithermal deposit in the Xiong'ershan ore concentration area. Ag-Pb-Zn mineralization mainly occurs in steeply dipping veins and breccia matrix. The relationship between large-scale Pb-Zn mineralization and widely developed alteration minerals remains unclear. Methods In order to discuss chlorite's significance related to Pb-Zn mineralization, chlorite composition in the Haopinggou Ag-Au polymetallic deposit has been analyzed by field geological observation and electron microprobe analysis (EMPA) in this paper. Results Three types of chlorite were observed in the deposit, occurring in altered wall rocks (Type I), in(with) Pb-Zn sulfides (Type II), and in(with) the breccia matrix (Type III). All three types of chlorite are prochlorites and fall within the compositional range of Fe-rich chlorite, indicating that they could be formed in a partially reducing acidic environment. Fe2+ for Mg2+ is the primary substitution in chlorite lattice, suggesting a close association between chlorite formation and mafic wall rocks. Based on the corrected chlorite geothermometer, these chlorites formed under aluminum-saturated conditions in the medium to low-temperature range of 196-239℃. The temperatures of chlorites associated with mineralization (Types II and III) are higher than those in chlorites around quartz veins (Type I). It is believed that during the mineralization process, the hydrothermal fluids evolved from acidic to nearly neutral conditions as the temperature gradually decreased. The initial acidic environment facilitated interaction between water and rocks, promoting the dissolution of surrounding rocks and providing space for the further precipitation of metal sulfides. The evolution of ore fluid properties also corresponds to the deposition process of Ag-Pb-Zn. The genesis of chlorite in the deposit is well-correlated with the ore-forming and holds significant prospecting value. (1) Type I chlorites mainly develop on both sides of quartz veins, formed by the dissolution and metasomatism of basic wall rocks by ore-bearing hydrothermal fluids. Type I chlorite's Fe and Mg components are mostly derived from the wall rocks. Although this type does not contain mineralization, it can be used to trace veins. (2) Type III chlorites reflect the migration process of ore-bearing hydrothermal fluids carrying dissolved minerals (biotite/clinopyroxene), which precipitate with changes in the physicochemical environment. Type III chlorite's Fe and Mg components are mainly introduced by ore-bearing hydrothermal fluids. This type of chlorite fills the intergranular pore spaces between minerals and easily replaces minerals such as biotite and hornblende, exhibiting apparent mineral alteration features in hand specimens, which is beneficial for prospecting.(3) The formation mechanism of Type II chlorites includes the possibilities mentioned above. This type of chlorite is formed by complete dissolution and metasomatism of cement in ore-bearing hydrothermal fluids, forming fine-grained cryptocrystalline chlorite fillings in breccia rocks. Ore-bearing hydrothermal fluids and wall rocks both contribute Fe and Mg in the chlorites. Hand specimens of Type II chlorite are dark green, disseminated and filled in the matrix, making it easy to distinguish. The chemical characteristics of Type II chlorites are similar to those of chemical characteristics of granite-related deposits, implying the contribution of magmatic fluids to ore-forming fluids. Conclusion The Haopinggou Ag-Au polymetallic deposit contains three types of chlorites. Their chemical characteristics all reflect an acidic and reducing metallogenic environment. In cation exchange, the primary substitution is Fe for Mg, and other substitutions are insignificant. The effect of Fe/(Fe+Mg) must be eliminated in order to calculate the temperature of such deposits using chlorite geothermometers. The formation mechanism of the three chlorites is closely related to mafic wall rock, and their chemical properties suggest the involvement of magmatic fluids in ore-forming fluids. Significance These three types of chlorite are well-matched with intense Ag-Pb-Zn mineralization and can serve as key indicators for locating Pb-Zn veins.

Paired electrolysis methods are appealing for chemical synthesis because they generate valuable products at both electrodes; however, development of such reactions is complicated by the need for both half-reactions to proceed under mutually compatible conditions. Here, a modular electrochemical synthesis (ModES) strategy bypasses these constraints using a redox reservoir (RR) to pair electrochemical half-reactions across aqueous and nonaqueous solvents. Electrochemical oxidation reactions in organic solvents, the conversion of 4-t-butyltoluene to benzylic dimethyl acetal and aldehyde in methanol or the oxidative C-H amination of naphthalene in acetonitrile, and the reduction of oxygen to hydrogen peroxide in water were paired using nickel hexacyanoferrate as an RR that can selectively store and release protons (and electrons) while serving as the counter electrode for these reactions. Selective proton transport through the RR is optimized and confirmed to enable the ion balance, and thus the successful pairing, between redox half-reactions that proceed with different rates, on different scales, and in different solvents (methanol, acetonitrile, and water).

Design guidelines for traditional cultural artefacts play an important role in Culturally Inspired Design (CID) activities and design education. In this paper, a comparative study was performed to assess the impact of present-day design guidelines for traditional Chinese cultural artefacts on novice designers in a CID process. In all, 42 novice designers enrolled in a cultural product design course participated in this study, under two different design conditions: an unaided condition and a guideline-aided condition. Each condition includes three stages: identification stage, translation stage and implementation stage. In the unaided condition, each participant was asked to finish an investigative report on traditional cultural artefacts without any guidance and then carry out a detailed cultural product design. These results were then compared with those of the participants in the guideline-aided condition, who received a design guideline for traditional cultural artefacts. The results were assessed by expert raters against six design metrics: breadth, depth, quantity, variety, novelty and quality. They revealed that the design guideline for traditional cultural artefacts in a CID process promoted the analysis of cultural features and increased the novelty and quality of design outcomes but resulted in decreased variety. We propose that the design guideline for traditional cultural artefacts may be useful as part of the design process and as a pedagogical tool in cultural creative design, but the best moment at which to introduce the design guideline should be further examined.