27 results on '"Li, Qing S."'
Search Results
2. Nocebo expectations rather than placebo expectations affect topical pain relief: A randomized clinical trial
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Yang, Mingxiao, Li, Qing S., Baser, Raymond E., Li, Xiaotong, Hou, Jason, and Mao, Jun J.
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- 2024
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3. COMT Val158Met Affects the Analgesic Response to Acupuncture Among Cancer Survivors With Chronic Pain
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Yang, Mingxiao, Baser, Raymond E., Khanin, Raya, Autuori, Isidora, Li, Qing S., Panageas, Katherine S., Orlow, Irene, and Mao, Jun J.
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- 2023
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4. In the weeds: a retrospective study of patient interest in and experience with cannabis at a cancer center
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Raghunathan, Nirupa J., Brens, Jessica, Vemuri, Swetha, Li, Qing S., Mao, Jun J., and Korenstein, Deborah
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- 2022
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5. Understanding interest, barriers, and preferences related to yoga practice among cancer survivors
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Desai, Krupali, Bao, Ting, Li, Qing S., Raghunathan, Nirupa J., Trevino, Kelly, Green, Angela, Xiao, Han, and Mao, Jun J.
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- 2021
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6. An exploratory study of salivary cortisol changes during chamomile extract therapy of moderate to severe generalized anxiety disorder
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Keefe, John R., Guo, Wensheng, Li, Qing S., Amsterdam, Jay D., and Mao, Jun J.
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- 2018
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7. Specific expectancies are associated with symptomatic outcomes and side effect burden in a trial of chamomile extract for generalized anxiety disorder
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Keefe, John R., Amsterdam, Jay, Li, Qing S., Soeller, Irene, DeRubeis, Robert, and Mao, Jun J.
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- 2017
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8. Influence of family on expected benefits of complementary and alternative medicine (CAM) in cancer patients
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Latte-Naor, Shelly, Sidlow, Robert, Sun, Lingyun, Li, Qing S., and Mao, Jun J.
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- 2018
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9. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial
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Mao, Jun J., Xie, Sharon X., Keefe, John R., Soeller, Irene, Li, Qing S., and Amsterdam, Jay D.
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Generalized anxiety disorder -- Care and treatment -- Research ,German chamomile -- Health aspects -- Research ,Herbal medicine -- Health aspects -- Research ,Biological sciences ,Health ,Science and technology - Abstract
ABSTRACT Background: Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders treated in primary care, yet current therapies have limited efficacy and substantial side effects. Purpose: To [...]
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- 2016
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10. Short-term open-label chamomile (Matricaria chamomilla L.) therapy of moderate to severe generalized anxiety disorder
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Keefe, John R., Mao, Jun J., Soeller, Irene, Li, Qing S., and Amsterdam, Jay D.
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Generalized anxiety disorder -- Care and treatment ,Antianxiety agents ,Biological sciences ,Health ,Science and technology ,University of Pennsylvania. Medical Center - Abstract
ABSTRACT Background: Conventional drug treatments for Generalized Anxiety Disorder (GAD) are often accompanied by substantial side effects, dependence, and/or withdrawal syndrome. A prior controlled study of oral chamomile (Matricaria chamomilla [...]
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- 2016
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11. Rhodiola rosea versus sertraline for major depressive disorder: a randomized placebo-controlled trial
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Mao, Jun J., Xie, Sharon X., Zee, Jarcy, Soellera, Irene, Li, Qing S., Rockwell, Kenneth, and Amsterdam, Jay D.
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Major depressive disorder -- Analysis -- Care and treatment ,Sertraline -- Comparative analysis ,Biological sciences ,Health ,Science and technology - Abstract
ABSTRACT Background: We performed a proof of concept trial to evaluate relative safety and efficacy of Rhodiola rosea (R. rosea) versus sertraline for mild to moderate major depressive disorder. Hypothesis: [...]
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- 2015
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12. Interest in and Barriers to Practicing Yoga among Family Caregivers of People with Cancer.
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Desai, Krupali, Applebaum, Allison J., Latte-Naor, Shelly, Pendleton, Eva M., Cheyney, Sarah, Li, Qing S., Ting Bao, Chimonas, Susan, and Mao, Jun J.
- Abstract
Background: Family caregivers of people with cancer report high levels of psychological distress. Yoga, with well‑documented mental health benefits, could be a useful intervention to address distress in this population. However, little is known about yoga practices among cancer caregivers. The present study evaluates their interest in and barriers to yoga practice. Methods: We conducted a cross‑sectional survey study of family caregivers of cancer patients at five suburban satellite locations of an academic cancer center. Survey items and statistical analyses focused on yoga usage as well as interest in and barriers to yoga practice. Results: Among 539 participants, most were females (64.8%), white (84.2%), and caring for a spouse or partner (54.7%). Interest in practicing yoga among study participants was 42.3%. Increased interest was independently associated with being females (odds ratio [OR] = 3.30, 95% confidence interval [CI] = 1.98–5.51, P < 0.001) and employed (part‑time: OR = 2.58, 95% CI = 1.1–6.18, P = 0.03; full‑time: OR = 1.77, 95% CI = 1.1–2.01, P = 0.02). Few participants (6.3%) were currently practicing yoga, although 31% had done so in the past. Sixty‑one percent of those who had practiced before their loved one’s diagnosis stopped practicing yoga afterward. Commonly cited barriers to yoga practice included time constraints (37.3%) and psychological obstacles (33.6%). About a quarter of those who had never practiced yoga lacked awareness of yoga’s benefits (26.6%). Conclusion: Despite the low use of yoga, interest in practicing was moderately high, especially among women and employed caregivers. As caregivers face numerous barriers to yoga practice, strategies are needed to overcome these barriers and help them access yoga’s health benefits. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Effects of Vigorous Versus Restorative Yoga Practice on Objective Cognition Functions in Sedentary Breast and Ovarian Cancer Survivors: A Randomized Controlled Pilot Trial.
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Deng, Gary, Bao, Ting, Ryan, Elizabeth L., Benusis, Lara, Hogan, Pasha, Li, Qing S., Dries, Annika, Konner, Jason, Ahles, Tim A., and Mao, Jun J.
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Purpose: Many cancer survivors experience cancer-related cognitive impairment (CRCI). We conducted a randomized controlled pilot trial of 2 types of yoga practice and evaluated their effects on participants' objective cognitive function. Methods: Sedentary breast or ovarian cancer survivors were randomized to practice either restorative yoga (with more meditative practice and minimal physical exertion) or vigorous yoga (with considerable physical exertion and minimal meditative practice) in 60-minute supervised sessions 3 times a week for 12 weeks, followed by 12 weeks of home practice. We used the NIH Toolbox Cognition Domain to evaluate participants at baseline, week 12, and week 24. Results: We enrolled 35 participants. For women in the restorative yoga group, overall cognitive function was statistically significantly improved at weeks 12 and 24 compared to baseline (P =.03 and 0.004; Cohen's D = 0.3 and 0.5). Fluid cognitive function also significantly improved at weeks 12 and 24 (P =.02 and 0.0007; Cohen's D = 0.3 and 0.6), whereas improvements in crystallized cognition were not significant. For women in the vigorous yoga group, significant improvement was only seen in tasks of crystallized cognition at week 24 (P =.03; Cohen's D = 0.5). Between-group comparisons showed that at week 24, women in the restorative yoga group had significantly higher scores on fluid cognition tasks. Conclusions: Patients who participated in yoga practice demonstrated improvement in objective cognitive function over time. Restorative yoga may be more effective in improving fluid cognitive function at week 24 when compared to vigorous yoga. These promising findings should be confirmed in definitive studies. Trial registration: Clinicaltrials.gov; NCT02305498 (Date Registered: December 2, 2014) [ABSTRACT FROM AUTHOR]
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- 2022
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14. Yoga for cancer survivors with chemotherapy-induced peripheral neuropathy: Health-related quality of life outcomes.
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Zhi, W. Iris, Baser, Raymond E., Zhi, Lillian M., Talukder, Dristi, Li, Qing S., Paul, Tina, Patterson, Clare, Piulson, Lauren, Seluzicki, Christina, Galantino, Mary L., and Ting Bao
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QUALITY of life ,PERIPHERAL neuropathy ,CANCER survivors ,YOGA ,BREAST cancer - Abstract
Background: Yoga is a meditative movement therapy focused on mind-body awareness. The impact of yoga on health-related quality of life (HRQOL) outcomes in patients with chemotherapy-induced peripheral neuropathy (CIPN) is unclear. Methods: We conducted a pilot randomized wait-list controlled trial of 8 weeks of yoga (n = 21) versus wait-list control (n = 20) for CIPN in 41 breast and gynecological cancer survivors with persistent moderate to severe CIPN. HRQOL endpoints were Hospital Anxiety and Depression Scale (HADS), Brief Fatigue Inventory (BFI), and Insomnia Severity Index (ISI). The Treatment Expectancy Scale (TES) was administered at baseline. We estimated mean changes and 95% confidence intervals (CIs) from baseline to weeks 8 and 12 and compared arms using constrained linear mixed models. Results: At week 8, HADS anxiety scores decreased −1.61 (−2.75, −0.46) in the yoga arm and −0.32 (−1.38, 0.75) points in the wait-list control arm (p = 0.099). At week 12, HADS anxiety scores decreased −1.42 (−2.57, −0.28) in yoga compared to an increase of 0.46 (−0.60, 1.53) in wait-list control (p = 0.017). There were no significant differences in HADS depression, BFI, or ISI scores between yoga and waitlist control. Baseline TES was significantly higher in yoga than in wait-list control (14.9 vs. 12.7, p = 0.019). TES was not associated with HADS anxiety reduction and HADS anxiety reduction was not associated with CIPN pain reduction. Conclusions: Yoga may reduce anxiety in patients with CIPN. Future studies are needed to confirm these findings. [ABSTRACT FROM AUTHOR]
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- 2021
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15. Yoga for Chemotherapy-Induced Peripheral Neuropathy and Fall Risk: A Randomized Controlled Trial.
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Bao, Ting, Zhi, Iris, Baser, Raymond, Hooper, Madeline, Chen, Connie, Piulson, Lauren, Li, Qing S, Galantino, Mary Lou, Blinder, Victoria, Robson, Mark, Seidman, Andrew, Panageas, Katherine S, and Mao, Jun J
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CANCER chemotherapy ,PERIPHERAL neuropathy ,ACCIDENTAL falls ,CANCER survivors ,YOGA - Abstract
Background Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect that worsens quality of life and increases the risk of falls in cancer survivors. Evidence of yoga's safety and efficacy in treating CIPN is lacking. Methods In a randomized controlled study, we assigned breast and gynecological cancer survivors with persistent moderate-to-severe CIPN pain, numbness, or tingling with a score of 4 or greater (0-10 numeric rating scale [NRS]) for at least 3 months after chemotherapy to 8 weeks of usual care or yoga focused on breathwork and musculoskeletal conditioning. Primary endpoint was treatment arm differences for NRS, and secondary endpoints were Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity subscale (FACT/GOG-Ntx), and Functional Reach Test after week 8. We tested treatment arm differences for each outcome measure using linear mixed models with treatment-by-time interactions. All statistical tests were two-sided. Results We randomly assigned 41 participants into yoga (n = 21) or usual care (n = 20). At week 8, mean NRS pain decreased by 1.95 points (95% confidence interval [CI] = -3.20 to -0.70) in yoga vs 0.65 (95% CI = -1.81 to 0.51) in usual care (P =.14). FACT/GOG-Ntx improved by 4.25 (95% CI = 2.29 to 6.20) in yoga vs 1.36 (95% CI = -0.47 to 3.19) in usual care (P =.035). Functional reach, an objective functional measure predicting the risk of falls, improved by 7.14 cm (95% CI = 3.68 to 10.59) in yoga and decreased by 1.65 cm (95% CI = -5.00 to 1.72) in usual care (P =.001). Four grade 1 adverse events were observed in the yoga arm. Conclusion Among breast and gynecological cancer survivors with moderate-to-severe CIPN, yoga was safe and showed promising efficacy in improving CIPN symptoms. [ABSTRACT FROM AUTHOR]
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- 2020
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16. Association Between Music Therapy Techniques and Patient-Reported Moderate to Severe Fatigue in Hospitalized Adults With Cancer.
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Atkinson, Thomas M., Liou, Kevi T., Borten, Michael A., Li, Qing S., Popkin, Karen, Webb, Andrew, DeRito, Janice, Lynch, Kathleen A., and Mao, Jun J.
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CANCER patients ,CONFIDENCE intervals ,HOSPITAL patients ,MUSIC therapy ,SELF-evaluation ,CROSS-sectional method ,DATA analysis software ,DESCRIPTIVE statistics ,CANCER fatigue ,ADULTS - Abstract
PURPOSE Cancer-related fatigue is a prevalent, debilitating symptom that contributes to increased health care utilization among hospitalized patients. Music therapy is a nonpharmacological intervention that uses active (eg, singing, selecting songs) and passive (eg, listening) techniques. Preliminary evidence from small trials suggests a potential benefit for cancer-related fatigue in the inpatient setting; however, it remains unclear which techniques are most effective. METHODS A cross-sectional mixed-methods study was performed to compare cancer-related fatigue before and after active or passive music therapy. Cancer-related fatigue was captured via the Edmonton Symptom Assessment Scale fatigue item. Patients were asked to provide postsession free-text comments. RESULTS A total of 436 patients (mean [standard deviation] age, 62.2 [13.4] years; n = 284 [65.1%] women; n = 294 [67.4%] white; active music therapy n = 360 [82.6%]; passive music therapy n = 76 [17.4%]) with a range of primary malignancies participated. Active music therapy was associated with a 0.88-point greater reduction in cancer-related fatigue (95% CI, 0.26 to 1.51; P = .006; Cohen's D, 0.52) at postsession as compared with passive music therapy when restricting the analysis to patients who rated their baseline cancer-related fatigue as moderate to severe (ie, ≥ 4; n = 236 [54.1%]). Free-text responses confirmed higher frequencies of words describing positive affect/emotion among active music therapy participants. CONCLUSIONS In a large sample of inpatient adults with diverse cancer disease types, active music therapy was associated with greater reduction in cancer-related fatigue and increased reporting of positive affect/emotions compared with passive music therapy. Additional research is warranted to determine the specific efficacy and underlying mechanisms of music therapy on cancer-related fatigue. [ABSTRACT FROM AUTHOR]
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- 2020
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17. Putative Antidepressant Effect of Chamomile (Matricaria chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression.
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Amsterdam, Jay D., Li, Qing S., Xie, Sharon X., and Mao, Jun J.
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ANTIDEPRESSANTS , *CHI-squared test , *MENTAL depression , *HAMILTON Depression Inventory , *HIGH performance liquid chromatography , *CLASSIFICATION of mental disorders , *ORAL drug administration , *HEALTH outcome assessment , *PSYCHOLOGICAL tests , *RESEARCH , *RESEARCH funding , *STATISTICAL sampling , *STATISTICS , *TRANQUILIZING drugs , *COMORBIDITY , *DATA analysis , *RANDOMIZED controlled trials , *BLIND experiment , *DATA analysis software , *GENERALIZED anxiety disorder , *PHARMACODYNAMICS - Abstract
Objectives: This exploratory analysis examined the putative antidepressant effect of Matricaria chamomilla L. (chamomile) extract in subjects with generalized anxiety disorder (GAD) with or without comorbid depression. It was hypothesized that chamomile extract would demonstrate similar anxiolytic activity in both subgroups, but superior antidepressant activity in GAD subjects with comorbid depression. Design: As part of a randomized double-blind placebo-controlled trial of chamomile extract for relapse prevention of GAD, 179 subjects received initial therapy with open-label chamomile extract 1500 mg daily for 8 weeks. Linear mixed-effect models were used to identify clinically meaningful changes in anxiety and depression symptoms between diagnostic subgroups. Settings/Location: The study took place at the University of Pennsylvania in Philadelphia, PA. Subjects: Subjects were ≥18 years old with a primary DSM IV-TR diagnosis of GAD. They were subcategorized into two diagnostic groups: GAD without comorbid depression (n = 100) and GAD with comorbid depression (n = 79). Interventions: Open-label chamomile extract 1500 mg was given daily for 8 weeks. Outcome measures: Generalized anxiety disorder (GAD-7), Hamilton rating scale for anxiety, Beck anxiety inventory, Hamilton rating scale for depression (HRSD), the six-item core HRSD (items 1, 2, 3, 7, 8, and 13), and the Beck depression inventory (BDI). Results: The authors observed similar anxiolytic effects over time in both diagnostic subgroups. However, there was a greater reduction in HRSD core symptom scores (p < 0.023), and a trend level reduction in HRSD total scores (p = 0.14) and in BPI total scores (p = 0.060) in subjects with comorbid depression. Conclusions:M. chamomilla L. may produce clinically meaningful antidepressant effects in addition to its anxiolytic activity in subjects with GAD and comorbid depression. Future controlled trials in subjects with primary major depressive disorder are needed to validate this preliminary observation. [ABSTRACT FROM AUTHOR]
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- 2020
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18. Reduction of Opioid Use by Acupuncture in Patients Undergoing Hematopoietic Stem Cell Transplantation: Secondary Analysis of a Randomized, Sham-Controlled Trial.
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Deng, Gary, Giralt, Sergio, Chung, David J, Landau, Heather, Siman, Jonathan, Li, Qing S, Lapen, Kaitlyn, and Mao, Jun J
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THERAPEUTIC use of narcotics ,ACUPUNCTURE ,ANALGESICS ,CANCER pain ,FISHER exact test ,HEMATOPOIETIC stem cell transplantation ,PAIN management ,SECONDARY analysis ,ODDS ratio - Abstract
Objective To evaluate acupuncture as a nonpharmacologic intervention for pain management in patients undergoing hematopoietic stem cell transplantation (HSCT). Methods Adult patients with multiple myeloma undergoing high-dose melphalan chemotherapy and autologous peripheral blood HSCT were randomized to receive either true (TA) or sham acupuncture (SA) once daily for five days starting on the day after chemotherapy. Use of pain medications and pain scores were assessed at baseline and at days 5, 15, and 30 after transplantation. Results Among 60 evaluable subjects, the SA group (vs TA) had greater than five times odds of increasing pain medication use from baseline. Among patients who were opioid nonusers at baseline, all 15 patients in the TA group remained free from opioid use at the end of the study. In contrast, 20% of those in the SA group (four of the 20 patients) started to use opioids after chemotherapy and stem cell infusion (day 5) and 40% (eight of the 20) had become opioid users by day 30 after HSCT (Fisher exact test P = 0.006). Among patients who were taking opioids at baseline, 14% in the TA group vs 10% in the SA group increased opioid intake at day 5, and 21% (TA) vs 30% (SA) at day 30 (P = 0.86). Conclusions Acupuncture appears to significantly reduce the need for pain medications during HSCT and the number of post-HSCT opioid users among baseline opioid nonusers. It warrants further studies as an opioid-sparing intervention for pain in HSCT patients. [ABSTRACT FROM AUTHOR]
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- 2020
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19. Awareness of Yoga for Supportive Care in Cancer: Implications for Dissemination.
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Raghunathan, Nirupa Jaya, Korenstein, Deborah, Li, Qing S., and Mao, Jun J.
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TUMOR treatment ,ACADEMIC medical centers ,CANCER patient psychology ,CANCER treatment ,CHI-squared test ,DIFFUSION of innovations ,INTELLECT ,PATIENT education ,RACE ,RESEARCH funding ,SEX distribution ,STATISTICS ,SURVEYS ,WHITE people ,YOGA ,EMAIL ,SOCIAL support ,INTEGRATIVE medicine ,SPECIALTY hospitals ,EDUCATIONAL attainment ,SOCIAL media ,PRINT materials ,SMARTPHONES ,CROSS-sectional method ,MOBILE apps ,DATA analysis software ,PATIENTS' attitudes ,DESCRIPTIVE statistics - Abstract
Objectives: Evidence indicates there are beneficial physical and psychosocial effects from practicing yoga in cancer patients and survivors. Despite yoga having been incorporated into National Comprehensive Cancer Network guidelines for symptoms ranging from fatigue to pain, patients' use of yoga for supportive care is low, ranging from 6% to 12%. This study aims to evaluate the awareness of yoga as therapy in an academic cancer center and the preferences for information delivery in this population. Design: We conducted a cross-sectional survey study at an urban academic cancer center. Responses regarding awareness and use of yoga were evaluated; those responding "not aware" were analyzed for preferences in information delivery. Univariate analysis was used to further characterize awareness of yoga for supportive care. Results: Of 303 respondents, 68% were female, 77% were white, and 75% were college educated. Despite access to yoga at the cancer center, 171 (56%) patients expressed they were not aware of the availability of yoga. Male patients were more likely to be unaware of yoga (72.4% vs. 48.8%, p = 0.045). Awareness did not vary by age, race, educational attainment, marital status, cancer type, or cancer stage. Of the 171 "not aware" patients, 87.6% expressed desire for information in the form of printed material, followed by 80.4% for e-mail, 37.6% for smartphone application, and 27.6% for social media. Non-white respondents were more likely to express interest in receiving information by smartphone. Conclusions: More than half of cancer patients were unaware of the yoga program despite advertising across the institution. Patients prefer varying methods for information receipt, with preferences differing by sociodemographic factors. Targeted education and outreach using appropriate engagement is needed to improve the awareness of yoga for symptom control in cancer patients. [ABSTRACT FROM AUTHOR]
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- 2019
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20. Determinants of mobile technology use and smartphone application interest in cancer patients.
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Raghunathan, Nirupa Jaya, Korenstein, Deborah, Li, Qing S., Tonorezos, Emily S., and Mao, Jun J.
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CANCER patients ,CANCER treatment ,MOBILE apps ,SMARTPHONES ,INFORMATION technology ,DIGITAL technology ,MULTIVARIATE analysis - Abstract
Background: Supportive care is a critical component of the treatment of cancer patients that is underutilized; patient lack of information about these services is an important barrier. Mobile technologies may be useful tools for delivering information, but cancer patient use of and interest in using them to learn about supportive care services have not been described. This study evaluates factors associated with cancer patient use of mobile technologies and interest in smartphone applications for information delivery about supportive care. Methods: We conducted a cross‐sectional survey among cancer patients from one urban academic hospital and 11 community hospitals. Patients self‐reported use of mobile technologies and interest in smartphone applications. Multivariate logistic analysis was used to identify determinants of mobile technology use and smartphone interest. Results: Among 631 participants, 466 (74%) reported regular use of mobile devices and 242 (39%) expressed an interest in supportive care information via smartphone applications. Patients under 45 were more likely to use a mobile device (Adjusted Odds Ratio [AOR] 6.8, 2.8‐16.9 95% CI, P < 0.001) and were interested in smartphone applications for delivery of information (AOR 3.2, 1.8‐5.9 95% CI, P < 0.001). Non‐white patients had similar use of mobile technology compared to whites but reported greater interest in smartphone application‐based information (AOR 3.4, 2.1‐5.5 95% CI, P < 0.001). Conclusion: Many patients expressed interest in smartphone application‐based information about supportive care services, especially those who are younger and non‐white. Future studies should investigate the characteristics of patients and smartphones applications that will optimize information delivery through a mobile technology platform. This study assesses the demographic and treatment‐related characteristics associated with mobile technology use and smartphone application interest in a mixed patient population from academic and community settings. It was found that age and race impact mobile technology use and interest in smartphone applications with younger and non‐white populations expressing an interest in smartphones at three times the reference group. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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21. Joint pain severity predicts premature discontinuation of aromatase inhibitors in breast cancer survivors.
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Kannie Chim, Xie, Sharon X., Stricker, Carrie T., Qing S. Li, Gross, Robert, Farrar, John T., De Michele, Angela, Mao, Jun J., Chim, Kannie, Li, Qing S, and DeMichele, Angela
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AROMATASE inhibitors ,BREAST cancer ,CYTOCHROME P-450 ,ETHYLAMINES ,CANCER treatment ,ANTINEOPLASTIC agents ,BREAST tumors ,PROGNOSIS ,RESEARCH funding ,TUMOR classification ,RETROSPECTIVE studies ,JOINT pain ,BRIEF Pain Inventory ,DISEASE complications ,THERAPEUTICS - Abstract
Background: Premature discontinuation of aromatase inhibitors (AIs) in breast cancer survivors compromises treatment outcomes. We aimed to evaluate whether patient-reported joint pain predicts premature discontinuation of AIs.Methods: We conducted a retrospective cohort study of postmenopausal women with breast cancer on AIs who had completed a survey about their symptom experience on AIs with specific measurements of joint pain. The primary outcome was premature discontinuation of AIs, defined as stopping the medication prior to the end of prescribed therapy. Multivariate Cox regression modeling was used to identify predictors of premature discontinuation.Results: Among 437 patients who met eligibility criteria, 47 (11%) prematurely discontinued AIs an average of 29 months after initiation of therapy. In multivariate analyses, patient-reported worst joint pain score of 4 or greater on the Brief Pain Inventory (BPI) (Hazard Ratio [HR] 2.09, 95% Confidence Interval [CI] 1.14-3.80, P = 0.016) and prior use of tamoxifen (HR 2.01, 95% CI 1.09-3.70, P = 0.026) were significant predictors of premature discontinuation of AIs. The most common reason for premature discontinuation was joint pain (57%) followed by other therapy-related side effects (30%). While providers documented joint pain in charts for 82% of patients with clinically important pain, no quantitative pain assessments were noted, and only 43% provided any plan for pain evaluation or management.Conclusion: Worst joint pain of 4 or greater on the BPI predicts premature discontinuation of AI therapy. Clinicians should monitor pain severity with quantitative assessments and provide timely management to promote optimal adherence to AIs. [ABSTRACT FROM AUTHOR]- Published
- 2013
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22. Effect of Acupuncture vs Sham Procedure on Chemotherapy-Induced Peripheral Neuropathy Symptoms: A Randomized Clinical Trial.
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Bao, Ting, Patil, Sujata, Chen, Connie, Zhi, Iris W., Li, Qing S., Piulson, Lauren, and Mao, Jun J.
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- 2020
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23. Music Therapy for Pain in Black and White Cancer Patients: A Retrospective Study.
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Lichtl, Alexandria, Casaw, Camila, Edwards, Jasmine, Popkin, Karen, Yu, Jennifer, Li, Qing S., Cadwell, Malik, Mao, Jun J., and Liou, Kevin T.
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MUSIC therapy , *PAIN management , *BLACK people , *CANCER pain , *CANCER patients , *MUSICOLOGY , *TUMOR treatment , *PAIN , *RETROSPECTIVE studies , *RESEARCH funding , *TUMORS , *OPIOID analgesics , *DISEASE complications - Abstract
Context: Racial pain disparities present challenges to cancer symptom management. Music therapy has demonstrated benefits for pain and is a promising treatment option for diverse populations due to music's multicultural presence. However, Black cancer patients are under-represented in music therapy trials.Objectives: This study compared pain severity, treatment approaches, and responses to music therapy between Black and white cancer patients. The findings will be used to generate hypotheses for future music therapy research to address racial disparities in pain management.Methods: We conducted a retrospective program evaluation of Black and white patients who received music therapy at an NCI-Designated Comprehensive Cancer Center. We used the Edmonton Symptom Assessment Scale (ESAS) to assess pain. We abstracted opioid use, music therapy referral reasons, and treatment approaches from the electronic health record.Results: Among 358 patients, 18% were Black, 42% reported moderate-to-severe pain, and 47% received opioids. Black patients reported higher baseline pain than white patients, but similar proportions of Black and white patients received opioids. Greater proportions of Black patients received music therapy referrals for pain (73% vs. 56%, P = 0.04) and engaged in active techniques (92% vs. 82%, P = 0.04). Black and white patients reported clinically meaningful pain reduction of similar magnitude after music therapy. Black patients discussed spirituality more commonly during music therapy, whereas white patients focused on family bonds.Conclusion: Black and white patients reported clinically meaningful pain reduction through varying music therapy approaches. Our findings may help inform cultural adaptations of music therapy to address racial pain disparities in oncology. [ABSTRACT FROM AUTHOR]- Published
- 2022
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24. A Technology-Assisted, Brief Mind-Body Intervention to Improve the Waiting Room Experience for Chemotherapy Patients: Randomized Quality Improvement Study.
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Bao T, Deng G, DeMarzo LA, Zhi WI, DeRito JL, Blinder V, Chen C, Li QS, Green J, Pendleton E, and Mao JJ
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Background: Patients waiting for chemotherapy can experience stress, anxiety, nausea, and pain. Acupressure and meditation have been shown to control such symptoms., Objective: This study aimed to evaluate the feasibility and effectiveness of an integrative medicine app to educate patients about these self-care tools in chemotherapy waiting rooms., Methods: We screened and enrolled cancer patients in chemotherapy waiting rooms at two Memorial Sloan Kettering Cancer Center locations. Patients were randomly assigned into an intervention arm in which subjects watched acupressure and meditation instructional videos or a control arm in which they watched a time- and attention-matched integrative oncology lecture video. Before and after watching the videos, we asked the patients to rate four key symptoms: stress, anxiety, nausea, and pain. We performed the analysis of covariance to detect differences between the two arms postintervention while controlling for baseline symptoms., Results: A total of 223 patients were enrolled in the study: 113 patients were enrolled in the intervention arm and 110 patients were enrolled in the control arm. In both groups, patients showed significant reductions in stress and anxiety from baseline (all P<.05), with the treatment arm reporting greater stress and anxiety reduction than the control arm (1.64 vs 1.15 in stress reduction; P=.01 and 1.39 vs 0.78 in anxiety reduction; P=.002). The majority of patients reported that the videos helped them pass time and that they would watch the videos again., Conclusions: An integrative medicine self-care app in the waiting room improved patients' experiences and reduced anxiety and stress. Future research could focus on expanding this platform to other settings to improve patients' overall treatment experiences., (©Ting Bao, Gary Deng, Lauren A DeMarzo, W Iris Zhi, Janice L DeRito, Victoria Blinder, Connie Chen, Qing S Li, Jamie Green, Eva Pendleton, Jun J Mao. Originally published in JMIR Cancer (http://cancer.jmir.org), 07.11.2019.)
- Published
- 2019
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25. Long-Term Chamomile Therapy of Generalized Anxiety Disorder: A Study Protocol for a Randomized, Double-Blind, Placebo- Controlled Trial.
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Mao JJ, Li QS, Soeller I, Rockwell K, Xie SX, and Amsterdam JD
- Abstract
Background: Anxiety symptoms are among the most common reasons for consumers to use Complementary and Alternative Medicine (CAM) therapy. Although many botanicals have been proposed as putative remedies for anxiety symptoms, there has been a paucity of controlled trials of these remedies. A preliminary study of the anxiolytic effect of Chamomile ( Matricaria recutita ) in humans suggests that chamomile may have anxiolytic and antidepressant activity. We now seek to conduct a 5-year randomized, double-blind, placebo-substitution study to examine the short and long-term safety and efficacy of chamomile extract in Generalized Anxiety Disorder (GAD)., Methods/design: 180 subjects with moderate to severe GAD will receive initial open-label pharmaceutical-grade chamomile extract 500-1,500 mg daily for 8 weeks. Responders to treatment who remain well for an additional 4 weeks of consolidation therapy, will be randomized to double-blind continuation therapy with either chamomile extract 500-1,500 mg daily or placebo for an additional 26 weeks. The primary outcome will be the time to relapse during study continuation therapy in each treatment condition. Secondary outcomes will include the proportion of subjects in each treatment condition who relapse, as well as the proportion of subjects with treatment-emergent adverse events. Quality of life ratings will also be compared between treatment conditions during short and long-term therapy., Discussion: Many individuals with mental disorders decline conventional therapy and seek CAM therapies for their symptoms. Thus, the identification of effective CAM therapy is of relevance to reducing the burden of mental illness. This study builds upon our prior findings of significant superiority of chamomile versus placebo in reducing GAD symptoms. We now extend these preliminary findings by conducting a randomized long-term safety and efficacy study of chamomile in GAD., Competing Interests: Conflicts of Interests All the authors had no conflict of interest to declare.
- Published
- 2014
- Full Text
- View/download PDF
26. Rhodiola rosea therapy for major depressive disorder: a study protocol for a randomized, double-blind, placebo- controlled trial.
- Author
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Mao JJ, Li QS, Soeller I, Xie SX, and Amsterdam JD
- Abstract
Background: Rhodiola rosea ( R. rosea ), a botanical of both western and traditional Chinese medicine, has been used as a folk remedy for improving stamina and reducing stress. However, few controlled clinical trials have examined the safety and efficacy of R. rosea for the treatment of major depressive disorder (MDD). This study seeks to evaluate the safety and efficacy of R. rosea in a 12-week, randomized, double-blind, placebo-controlled, parallel group study design., Methods / Design: Subjects with MDD not receiving antidepressant therapy will be randomized to either R. rosea extract 340-1,360 mg daily; sertraline 50-200 mg daily, or placebo for 12 weeks. The primary outcome measure will be change over time in the mean 17-item Hamilton Depression Rating score. Secondary outcome measures will include safety and quality of life ratings. Statistical procedures will include mixed-effects models to assess efficacy for primary and secondary outcomes., Discussion: This study will provide valuable preliminary information on the safety and efficacy data of R. rosea versus conventional antidepressant therapy of MDD. It will also inform additional hypotheses and study design of future, fully powered, phase III clinical trials with R. rosea to determine its safety and efficacy in MDD.
- Published
- 2014
- Full Text
- View/download PDF
27. Joint pain severity predicts premature discontinuation of aromatase inhibitors in breast cancer survivors.
- Author
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Chim K, Xie SX, Stricker CT, Li QS, Gross R, Farrar JT, DeMichele A, and Mao JJ
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms mortality, Breast Neoplasms pathology, Female, Humans, Middle Aged, Neoplasm Staging, Prognosis, Retrospective Studies, Risk Factors, Survivors, Antineoplastic Agents adverse effects, Antineoplastic Agents therapeutic use, Aromatase Inhibitors adverse effects, Aromatase Inhibitors therapeutic use, Arthralgia etiology, Breast Neoplasms complications, Breast Neoplasms drug therapy
- Abstract
Background: Premature discontinuation of aromatase inhibitors (AIs) in breast cancer survivors compromises treatment outcomes. We aimed to evaluate whether patient-reported joint pain predicts premature discontinuation of AIs., Methods: We conducted a retrospective cohort study of postmenopausal women with breast cancer on AIs who had completed a survey about their symptom experience on AIs with specific measurements of joint pain. The primary outcome was premature discontinuation of AIs, defined as stopping the medication prior to the end of prescribed therapy. Multivariate Cox regression modeling was used to identify predictors of premature discontinuation., Results: Among 437 patients who met eligibility criteria, 47 (11%) prematurely discontinued AIs an average of 29 months after initiation of therapy. In multivariate analyses, patient-reported worst joint pain score of 4 or greater on the Brief Pain Inventory (BPI) (Hazard Ratio [HR] 2.09, 95% Confidence Interval [CI] 1.14-3.80, P = 0.016) and prior use of tamoxifen (HR 2.01, 95% CI 1.09-3.70, P = 0.026) were significant predictors of premature discontinuation of AIs. The most common reason for premature discontinuation was joint pain (57%) followed by other therapy-related side effects (30%). While providers documented joint pain in charts for 82% of patients with clinically important pain, no quantitative pain assessments were noted, and only 43% provided any plan for pain evaluation or management., Conclusion: Worst joint pain of 4 or greater on the BPI predicts premature discontinuation of AI therapy. Clinicians should monitor pain severity with quantitative assessments and provide timely management to promote optimal adherence to AIs.
- Published
- 2013
- Full Text
- View/download PDF
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