185 results on '"Lehmann, Kuno'
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2. CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)
- Author
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Roth, Lilian, Huynh-Russo, Linda, Heeb, Laura, Ulugöl, Sima, Freire Dos Santos, Rafael, Breuer, Eva, Ungethüm, Udo, Haberecker, Martina, Pauli, Chantal, Koelzer, Viktor, Lehmann, Kuno, and Gupta, Anurag
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- 2024
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3. The role of resection in hepatocellular carcinoma BCLC stage B: A multi-institutional patient-level meta-analysis and systematic review
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Lopez-Lopez, Victor, Kalt, Fabian, Zhong, Jian-Hong, Guidetti, Cristiano, Magistri, Paolo, Di Benedetto, Fabrizio, Weinmann, Arndt, Mittler, Jens, Lang, Hauke, Sharma, Rohini, Vithayathil, Mathew, Tariq, Samir, Sánchez-Velázquez, Patricia, Rompianesi, Gianluca, Troisi, Roberto Ivan, Gómez-Gavara, Concepción, Dalmau, Mar, Sanchez-Romero, Francisco Jose, Llamoza, Camilo, Tschuor, Christoph, Deniz, Uluk, Lurje, Georg, Husen, Peri, Hügli, Sandro, Jonas, Jan Philipp, Rössler, Fabian, Kron, Philipp, Ramser, Michaela, Ramirez, Pablo, Lehmann, Kuno, Robles-Campos, Ricardo, and Eshmuminov, Dilmurodjon
- Published
- 2024
- Full Text
- View/download PDF
4. CD8 + T-cells restrict the development of peritoneal metastasis and support the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC)
- Author
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Lilian Roth, Linda Huynh-Russo, Laura Heeb, Sima Ulugöl, Rafael Freire Dos Santos, Eva Breuer, Udo Ungethüm, Martina Haberecker, Chantal Pauli, Viktor Koelzer, Kuno Lehmann, and Anurag Gupta
- Subjects
Cytoreductive surgery (CRS), Hyperthermic Intraperitoneal Chemotherapy (HIPEC), Peritoneal Metastasis (PM), Adaptive immunity, Cancer-testing antigens, Patient-derived tumor organoids ,Medicine ,Science - Abstract
Abstract Multimodal therapy for peritoneal metastasis (PM) including cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provides long-term survival in highly selected colorectal cancer patients. Mechanisms behind HIPEC are unknown and may include induction of adaptive immunity. We therefore analyzed human PM samples and explored the impact of HIPEC in experimental models. Human samples from colorectal primary tumors (n = 19) and PM lesions (n = 37) were examined for the presence of CD8 + T-cells and their association with disease free (DFS) and overall survival (OS). CD8 + T cell response after HIPEC was assessed using an in-vivo PM mouse model, tumor cell lines and patient-derived tumor organoids. Patients with high intraepithelial CD8 + T cell counts showed longer DFS and OS. In the mouse model, HIPEC controlled growth of PM and increased numbers of functional granzyme positive CD8 + T cells within tumors. Cell lines and human organoids that were treated with heated chemotherapies showed immunogenic changes, reflected by significantly higher levels of MHC-class I molecules and expression of Cancer Testis Antigens Cyclin A1 and SSX-4. Using in-vitro co-culture assays, we noticed that cancer cells treated with heated chemotherapy primed dendritic cells, which subsequently enhanced effector functions of CD8 + T cells. The presence of CD8 + T-cells within PM lesions is associated with prolonged survival of patients with PM. Data from PM mouse model and in-vitro assay show that heated chemotherapies induce immunogenic changes on cancer cells leading to induction of CD8 + T-cells mediated immunity, which seems to control growth of PM lesions in mice after HIPEC.
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- 2024
- Full Text
- View/download PDF
5. Low‐dose aspirin confers protection against acute cellular allograft rejection after primary liver transplantation
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Oberkofler, Christian E, Raptis, Dimitri A, Müller, Philip C, da Silva, Richard X Sousa, Lehmann, Kuno, Ito, Takahiro, Owen, Timothy, Pollok, Joerg‐Matthias, Parente, Alessandro, Schlegel, Andrea, Peralta, Peregrina, Winter, Erin, Selzner, Markus, Fodor, Margot, Maglione, Manuel, Jaklitsch, Manuel, Marques, Hugo P, Chavez‐Villa, Mariana, Contreras, Alan, Kron, Philipp, Lodge, Peter, Alford, Scott, Rana, Abbas, Magistri, Paolo, Di Benedetto, Fabrizio, Johnson, Bethany, Kirchner, Varvara, Bauldrick, Francis, Halazun, Karim J, Ghamarnedjad, Omid, Mehrabi, Arianeb, Basto, Samanta Teixeira, Fernandes, Eduardo SM, Paladini, Jose, de Santibañes, Martin, Florman, Sander, Tabrizian, Parissa, Dutkowski, Philipp, Clavien, Pierre‐Alain, Busuttil, Ronald W, Kaldas, Fady M, and Petrowsky, Henrik
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Digestive Diseases ,Liver Disease ,Clinical Research ,Transplantation ,Organ Transplantation ,Prevention ,Adult ,Humans ,Liver Transplantation ,Cohort Studies ,Graft Rejection ,Thrombosis ,Allografts ,Graft Survival ,Retrospective Studies ,Risk Factors ,Clinical Sciences ,Surgery - Abstract
This study investigated the effect of low-dose aspirin in primary adult liver transplantation (LT) on acute cellular rejection (ACR) as well as arterial patency rates. The use of low-dose aspirin after LT is practiced by many transplant centers to minimize the risk of hepatic artery thrombosis (HAT), although solid recommendations do not exist. However, aspirin also possesses potent anti-inflammatory properties and might mitigate inflammatory processes after LT, such as rejection. Therefore, we hypothesized that the use of aspirin after LT has a protective effect against ACR. This is an international, multicenter cohort study of primary adult deceased donor LT. The study included 17 high-volume LT centers and covered the 3-year period from 2013 to 2015 to allow a minimum 5-year follow-up. In this cohort of 2365 patients, prophylactic antiplatelet therapy with low-dose aspirin was administered in 1436 recipients (61%). The 1-year rejection-free survival rate was 89% in the aspirin group versus 82% in the no-aspirin group (hazard ratio [HR], 0.77; 95% confidence interval [CI], 0.63-0.94; p = 0.01). The 1-year primary arterial patency rates were 99% in the aspirin group and 96% in the no-aspirin group with an HR of 0.23 (95% CI, 0.13-0.40; p
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- 2022
6. Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries
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Dönmez, A Eylül, Goswami, Aakansha Giri, Raheja, Aashna, Bhadani, Aayush, El Kady, Abd Elrahman Safwat, Alniemi, Abdalaziz, Awad, Abdalkarim, Aladl, Abdalla, Younis, Abdalla, Alwali, Abdallah, Khalil, Abdallah, Mansour, Abdallah, Elkhouly, Abdallah Mohamed, Rashad Temerik, Abdallah, Hasan, Abdallatef, Chied, Abdelhafid, Abdraba, Abdelhamid, Hrora, Abdelmalek, Abdelshafi, Abdelrahman, Alwali, Abdelrahman, Maraqa, Abdelrahman, Ghaffar, Abdul, Chekfa, Abdul Jabar, Al Balushi, Abdul Majeed, Quddus, Abdul, Hammadieh, Abdul Rahman, Muntaka, Abdul-Jalilu Mohammed, Asekun, Abdulazeez, Alshahrani, Abdulaziz, Jowharji, Abdulaziz, Alshukre, Abdulbaset, Khair Etareig, Abdulhafid, Abubakar Abdulkarim, Abdulhafiz, Ashiru, Abdulhafiz, Alailesh, Abdulhamid, Al-Mallah, Abdullah, Baydoun, Abdullah, Chaudhry, Abdullah, Askin, Abdullah Emre, Almutairi, Abdulmjeed, Belkhair, Abdulmunem, Abdllah, Abdulrahman, Alhammali, Abdulrahman, Basalim, Abdulrahman, Abouelnagah, Abdulrahman Galal Mohamed Mostafa, Ghazal, Abdulrahman, Mohammed, Abdulrahman, Qasem, Abdulrahman, Anadani, Abdulrazak, Jimoh, Abdulrazaq, Lawal, Abdulrazzaq Oluwagbemiga, Khaity, Abdulrhman, Lawal, Abdulwahab, Elzoubi, Abdurrahim Esseid, Sheshe, Abdurrahman Abba, Cetişli, Abdurrahman Furkan, Oyedele, Abeeb, Aljahdali, Abeer, Aboelnasr, Abeer Gamal Elsyed, Demessie, Abel, Bhargava, Abhilasha, Sonkar, Abhinav Arun, Bavaharan, Abhirame, Khan, Abid, Campbell, Abigail, Oyelekan, Abimbola Adeola Akintunde, Okunlola, Abiodun Idowu, Ojewuyi, Abiodun, Ekerin, Abiola, Saleh, Abobakr, Khairy, Abouelatta, Muthunayagam, Abraham Benjamin, Botha, Abraham, Teshome Sahilemariam, Abraham, Nawawi, Abrar, Muhammad, Abubakar Bala, Dahiru, Abubakar, Yahaya, Abubakar, Abdelmalik, Abubaker, Anuar, Abul Akmal Arif, Ousseini, Adakal, Leon -Del- Angel, Adalberto, Frankel, Adam, Gyedu, Adam, Lim, Adam, Lukáč, Adam, Peckham-Cooper, Adam, Sabbah, Adam, Varga, Adam, Sanou, Adama, Issaka, Adamu, Ningi, Adamu, Yeshitila, Addis, Yingess, Addisu, Olugbami, Adebayo, Moses, Damola-Okesiji, Adebola, Lawal, Adedayo, Ojo, Adedoyin, Hashmi, Adeel, Fakoya, Adegbolahan, Ishola, Adegoke, Abiodun, Adekunle, Ajayi, Adekunle, Mouffokes, Adel, Bonelli, Adele, Adekoya, Adeleke, Akeem Aderogba, Adeleke, Özcan, Adem, Ayoade, Ademidun, Adeyeye, Ademola, Agbaje, Ademola, Talabi, Ademola, Ademuyiwa, Adesoji, Adewumiya, Adesoji, Ademuyiwa, Adesoji O, Aderounmu, Adewale, Adisa, Adewale, Oke, Adewale, Ragab, Adham, Alzadjali, Adil, Baksi, Aditya, Jayapalan, Aditya, Md Yunos, Adnan, Pisanu, Adolfo, Salazar, Adolfo, Salinas Barragan, Adrian Alberto, Fox, Adrian, Stollberg, Adrian, Franco, Adriana, Neves, Adriana, Vricheva, Adriana, Hodonou, Adrien Montcho, Aghayeva, Afag, Liaquat, Affifa, Alsultan, Afnan, Morad, Afnan, Kalidis, Afroditi Angella, Gkouniaroudi, Agathi, Karakosta, Agathi, Lovi, Agbenya, Yevide, Agossou Barthélémy, Duro, Agustin, Rodriguez Gonzalez, Agustin, Tariq, Ahbala, Abaidalla, Ahmad, Abuhammad, Ahmad, Abuhantash, Ahmad, Mansour, Ahmad Adel, Ahmad Zaidi, Ahmad Al Hafeez, Alahmad Alismael, Ahmad, Alayed, Ahmad, Alfarwan, Ahmad, Alhaj, Ahmad, Ali, Ahmad, Alroobi, Ahmad, Alsheikh, Ahmad, Alusef, Ahmad, Alzu'Bi, Ahmad, Kayali, Ahmad Amir, Bouhuwaish, Ahmad, Doghaim, Ahmad, El-Sherbiney, Ahmad, Ghazal, Ahmad, Ramly, Ahmad Nasir, Raza, Ahmad, Qureshi, Ahmad Uzair, Arnaout, Ahmad Yamen, Abdelhamid, Ahmed, Abuthaher, Ahmed, Adel, Ahmed, Ahmayda, Ahmed, Al-Mouahhed, Ahmed, Alagha, Ahmed, Albalawi, Ahmed, Albhaisi, Ahmed, Alrifaee, Ahmed, Azam, Ahmed, Barakat, Ahmed, Al-Hajjaj, Ahmed Basim Abed, Dawoud, Ahmed, El Shamarka, Ahmed, El-Bastwesy, Ahmed, Elghrieb, Ahmed, Elkhalifa, Ahmed, Elmosalamy, Ahmed, Elshazli Mahmoud, Ahmed, Montaser, Ahmed G., Gbeadese, Ahmed, Haty, Ahmed, K. Ali, Ahmed, Awad, Ahmed K., Kedwany, Ahmed, Khalleefah, Ahmed, Abbas, Ahmed M., Allam, Ahmed M., Maher, Ahmed, Elsayed, Ahmed Mohamed, Mohamed Ibrahim Mohamed, Ahmed, Mostafa, Ahmed, Nabil, Ahmed, Nada, Ahmed, Ragheb, Ahmed, Abdelrahman, Ahmed Saber Mohamed, Sabry, Ahmed, Sakr, Ahmed, Elkhodary, Ahmed Salah, Shaheen, Ahmed, Ammar, Ahmed Siddique, Hameed, Ahmer, Akmercan, Ahmet, Aslan, Ahmet, Barcin, Ahmet, Ciftci, Ahmet Burak, Bozkurt, Ahmet Çağlar, Sarı, Ahmet Can, Yaşar, Ahmet Can, Develioğlu, Ahmet, Öztürk, Ahmet Mücteba, Sanli, Ahmet Necati, Rencuzogullari, Ahmet, Yildiz, Ahmet, Kaan, Ahmet Zahit, Toi, Ahouefa Chourika Sakinath, Aljamoudi, Aida, Cheung, Aiden Chak Kei, Gkoutoula, Aikaterini, Kalogeropoulou, Aikaterini, Sarafi, Aikaterini, Abo Al Shamat, Aiman, Sanon, Aimé Serge Titianma, Sanon, Aimée Florence, Hiller, Aimée, Costas-Chavarri, Ainhoa, Lombardero, Ainhoa, Fraile, Ainoa, Bojazyah, Aisha, Kamal, Aisha, Gill, Aisling, Hada, Aïssatou, Gulla, Aiste, Mačiulaitytė, Aistė, Sukumar, Aiswarya, Landaluce-Olavarria, Aitor, Sainz Lete, Aitor, Pal, Ajay Kumar, Malik, Ajaz Ahmad, Horiguchi, Akihiko, Kocaay, Akin Firat, Akinkuolie, Akinbolaji, Olabode, Akingunloye, Fadipe, Akinniyi, Akinmade, Akinola, Darkwa Boateng, Akosua, Appiah-Kubi, Akosua Yeboaa, Alkaseek, Akram, Kadamani Abiyomaa, Akram, Anand, Akshay, Oppong, Akua, Opoku-Agyapong, Akwasi, Asharaf, Al Ameen, Ahmed, Al Samoul, Andani, Al-Hassan Dasana, Alkharusi, Al-Salt, Abd Elsattar, Alaa, Alragheai, Alaa, Alsalahat, Alaa Atta, Hawarah, Alaa, Aldirani, Alaa Nasib, Shabkah, Alaa, Nixon Fulli, Alafi Francis, Nguyen, Alain, Mustafa, Alamin, Joseph, Alan, Huws, Alaw, Aregawi, Alazar Berhe, Sanchez Gallego, Alba, Torroella, Alba, Vazquez Melero, Alba, Dauksa, Albertas, Abreu Da Silva, Alberto, Brun-Peressut, Alberto, Barranquero, Alberto G, Gegúndez Simón, Alberto, Gerundo, Alberto, Navarrete-Peón, Alberto, Viacava, Alberto, Vilar, Alberto, Adam, Albushra Altayeb, Jarimba, Aldo, Johnson, Aleena, Nuñez Venzor, 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Ana Marta, Minaya-Bravo, Ana, Lourenço, Ana Rita, Mateus Loureiro, Ana Rita, Sánchez Gollarte, Ana, Tvaladze, Ana, Veira, Ana, Perja, Ana-Maria, Dusabimana, Anaclet, Herewini, Anahera, Fatima, Anam, Zafar, Anam, Bangar, Anant, Kutma, Ananta, Mehta, Ananya, Alqerem, Anas, Jaber, Anas, Mourtzouni, Anastasia, Theochari, Anastasia, Zarafidou, Anastasia, Smyrnis, Anastasios, Tsechpenakis, Anastasios, Zakaria, Andee Dzulkarnaen, Cardoso Almeida, Andre, Pita, André, Torbey, André, Abreu, Andrea, Barberis, Andrea, Bartalini Cinughi De Pazzi, Andrea, Belli, Andrea, Sironi, Andrea Carlo, Damigella, Andrea, Manetti, Andrea, Mingoli, Andrea, Natili, Andrea, Police, Andrea, Razzore, Andrea, Scacchi, Andrea, Vazquez Fernandez, Andrea, Luzzi, Andrea-Pierre, Brosin, Andreas, Efstathiou, Andreas, Kirschniak, Andreas, Panagakis, Andreas, Pilavas, Andreas, Scheiwiller, Andreas, Skarpas, Andreas, Chitul, Andrei, Trif, Andrei, Ferreira, Andreia, Silva, Andreia, Subocius, Andrejus, Cembellin, Andres, García Marín, Andrés, Ang, Andrew, Gray, Andrew, Li, Andrew, Skreka, Androniki-Maria, Abdul Rahim, Andy Adib, Bhangu, Aneel, Moncy, Aneena, Mwanjoka, Anganile, Fernández Camuñas, Ángel, De Jesús Gil, Ángela, Molero, Ángela, Sultana, Angela, Suárez Álvarez, Angeles Anabel, Nava Franco, Angelica Magaly, Autiak Ayii Chol, Angelo, Serao, Angelo, Nikolaou, Angelos I., Hassanin, Angham, Evans, Angharad, Vu, Anh, Lala, Anil Kumar, Luther, Anil, Sundaram, Anil, Cerovac, Anis, Abgeko, Anita Eseenam, Agbeko, Anita Eseenam, Sharma, Anju, Gupta, Ankit, Jain, Ankit, Attili, Ann, Alecci, Anna, D'Amore, Anna, Domenech Plana, Anna, Gut, Anna Eleonora, John, Anna, Lareida, Anna, Pesce, Anna Lisa, Paspala, Anna, Sharp, Anna, Victor, Anna, Comandatore, Annalisa, Olsen, Annelisse, Yiallourou, Anneza, Loizou, Annita, Sharma, Anshuman, Asare Twumasi, Anthony, Davor, Anthony, Tabiim, Anthony Jagri, Lin, Anthony, Szpytko, Anthony, Walfor, Anthony, Oosterkamp, Antje, Kachi, Antoine, Khoneisser, Antoine, Bediako Bowan, Antoinette, Sumbaev, Anton, Deserra, Antonello, Punzengruber, Antonia, Thanasa, Antonia, Azzinnaro, Antonio, Castaldi, Antonio, Curado Soriano, Antonio, García Domínguez, Antonio, Lai, Antonio, Martinez German, Antonio, Masciandaro, Antonio, Miele, Antonio, Pesce, Antonio, Ramírez Beas, Antonio, Ramos Bonilla, Antonio, Ramos-De la Medina, Antonio, Zerbinati, Antonio, Athanasiou, Antonios, Panagidis, Antonios, Vezakis, Antonios, Pilavas, Antonis, Boynes, Antony, Mishra, Anurag, Singh, Anurag, Appukuttan, Anuraj, Alhamadi, Anwaar, Gusibat, Anwar, Seidu, Anwar Sadat, Fuertes Muñoz, Anyely Nataly, Abbas, Aoss, Shanker, Aparajeya, Balta, Apostolia, Panagopoulos, Apostolis, Roslani, April, Tahir, Aqsa, Hernández, Araceli, Roumieh, Aram, Pinto, Arbey, Khanduri, Archana, Isik, Arda, Dhinakar, Arelly Samuel Paul, Ioannidis, Argyrios, Tsiaka, Ariadni, Balconi, Arianna, Petrungaro, Arianna, Narin, Arif Emir, Plastiras, Aris, Papadopoulos, Aristeidis, Kontokostopoulos, Aristeidis-Panagiotis, Bang, Aristide, Nikitaras, Aristotelis, Akiba, Arit, Jindal, Arjun, Bedzhanyan, Arkady, Fajardo, Arlene, Antinori, Armando, Galvan, Armando, Belarmino, Armin, Mustafa, Arooba, Mathew, Arpit, Pillai, Arpit, Alrababah, Arqam, Shoker, Arran, Hai, Arrham, Anand, Arun, Bhatti, Arun, Nair, Arun, Prasath S V, Arun, Krishna, Arunachalam, Sinha, Arvind, Abdulnabi, Arwa, Aboumedian, Arwa, Faisal, Arwa, Haidar, Arwa, J, Arya, Ahmed, Asaad, Choudhry, Asad, Albager, Asawer, Jha, Ashesh Kumar, Chhabra, Ashish, Choudhrie, Ashish, Gupta, Ashish, Kumar, Ashish, Tirkey, Ashish, Oommen, Ashok Ninan, Al-Bahla, Ashraf, Bakri, Ashraf, Maghrabi, Ashraf, Mahendran, Ashuvini, Kumar, Ashwani, Das, Asish, Eisa, Assem, Comella, Assia, Shanmugalingam, Aswin, Boztaş Demir, Asya Eylem, Zubillaga-Mares, Asya, Altawaiha, Ata'O Allah, Mitsala, Athanasia, Katsiou, Athanasia-Faidra, Bakalis, Athanasios, Marinis, Athanasios, Migdanis, Athanasios, Soumpasis, Athanasios, Syllaios, Athanasios, Tampakis, Athanasios, Çakmak, Atil, Rahman, Atiqur, Suroy, Atul, L'Hostis, Audrey, Parseliunas, Audrius, Ali, Aun, Rakotondrainibe, Aurelia, Goliath, Austin, Arustamyan, Avetik, Sukhdev Jadhav, Avinash, Chaudhary, Awais, Kumar, Awanish, Denz, Axel, Al Kaddah, Aya, Alaqtash, Aya, Ehab, Aya, Essamei, Aya, Kelzia, Aya, Farrag, Ayatallah, Myintmo, Aye Myat, Bibi, Ayesha, Iqbal, Ayesha, Irshad, Ayeza, Sinjab, Ayham, Izgiş, Aylin, Almugaddami, Ayman Adel Yousuf, Albatanony, Ayman, Ayeni, Ayodeji, Williams, Ayooluwa, AbuNemer, Ayoub, Benmansour, Ayoub, Nidali, Ayoub, Vig, Ayushi, Emran, Ayyah, Abbas, Azadar, Ekpeti, Azuka, Janjua, Azwa, Fathi, Azza, Alzahrani, Azzah, Rehmani, Babar, Ayoade, Babatunde A, Mustapha, Babatunde, L, Badareesh, Alsharari, Bader, Balaravi Pillai, Balakavitha, Balagobi, Balasingam, Mohamad, Balqees, Ibrahim, Bana, Ali, Bandar, Alqahtani, Bandar, Paul, Banderembako, Yigit, Banu, Révérien, Banziriyubusa, Dweik, Bara', Yacoub, Bara', Alzoubi, Baraa, Chkir, Baraa, M.J. Alhaj, Baraa, Binda, Barbara, Carvalho, Bárbara, Demurtas, Barbara, Dieck, Bárbara, Freire, Bárbara, Gama, Bárbara, Habrat, Barbara, Tinoco, Bárbara, Hernandez Cervantes, Barbara Yordanis, East, Barbora, Maguire, Barry, Mckay, Bartholomew, Żaczek, Bartłomiej, Dawud, Bashar, Allbakosh, Bashir, Yunusa, Bashir, Aminu, Bashiru, Ibi, Bashkim, D'Souza, Basil, Alazabi, Basma, Algettawi, Basma, Sharaf Eldin, Basma, Hameed, Basmah Hilal, Abboud, Bassam, Al Soudi, Bassam, Fahmy, Bassam, Ranjous, Batoul, Bereket Araya, Batseba, Eyduran, Batuhan, Alsaid, Bayan, Guerra, Bayron, Markowska, Beata, De Zolt Ponte, Beatrice, Robertson-Jones, Beatrice, Sperotto, Beatrice, Cordeiro, Beatriz, Cuneo, Beatriz, De Andrés-Asenjo, Beatriz, Louro, Beatriz, Estraviz, Begoña, Khan, Belawl, Abdennour, Belkadi, Calcaño, Bellanirys, Kigwe, Ben, Boakye, Benedict, Ağca, Bengi, Togay, Bengü, Esposito, Beniamino, Chiman, Benjamin Guarken, Lulham-Robinson, Benjamin, Martin, Benjamin, Peter, Bennett, Özcan, Berkay, Seshie, Bernard Kofi, Maanikuu, Bernard, Lopes Patrício, Bernardo, Khattab, Besher, Johnson, Bethan, Mcdermott, Bethany, Neall, Bethany, Wang, Betty, Roopavathana. S, Beulah, Fosh, Beverley, Sarang, Bhakti, Sv, Bharath, R Budihal, Bhargavi, Devkaran, Bhavesh, Van Zyl, Bianca, Kharga, Bikram, Al-Sarireh, Bilal, Ali, Bilal, Duman, Bilgesu, Baca, Bilgi, Down, Billy, Mengesha, Birhanu, Owusu Ansah, Bismark, Radja, Bitour, Sime, Bizuneh, Capdevila Vilaró, Blanca, Izedomi, Blessing Ohikhuare, Hao, Bo Zhen, Nimako, Boateng, Phakathi, Boitumelo, Sehgal, Boney, Cakpo, Boniface, Alrayes, Bourhan, Mao, Boyuan, Bogdan-Gabriel, Bratu, Bengaly, Bréhima, Williams, Brielle, Cismasiu, Brigitta, Helou, Brigitte, Davies, Brooke, Arya, Brundha, Cirillo, Bruno, Nardo, Bruno, Pinto, Bruno, Scotto, Bruno, Vieira, Bruno, Kadir, Bryar, Albaihani, Bshaer, Calik, Bulent, Citgez, Bulent, Celik, Burak, Azhar, Burhansyah, Alshaikh, Bushra, Kum, Büşra, Killoran, Callie, Nwachukwu, Callistus, Hidalgo Salinas, Camila, Brasset, Camille, Bertoglio, Camillo Leonardo, Vasquez Maya, Camilo, Zapata Syro, Camilo, Akgün, Can, Yurttas, Can, Semeraro, Candy, Lategan, Carina, Boven, Carine, Uwakunda, Carine, Leal Ferrandis, Carla, Margiani, Carla, Piras, Carla, Samojeden, Carla, Vitiello, Carla, Feo, Carlo V., Bôto, Carlos, Roman Ortega, Carlos Fernando, Ferreras García, Carlos, Figueiredo, Carlos, García-Salas, Carlos, González, Carlos, González Baez, Carlos, Gracia-Roche, Carlos, Guijarro Moreno, Carlos, Hernandez Diaz, Carlos, Ferrero, Carlos Ignacio, Perez Rivera, Carlos J, Jezieniecki, Carlos, Pérez - Padrón, Carlos Josué, León-Espinoza, Carlos, Nuño-Guzmán, Carlos M., Macedo Cardoso De Oliveira, Carlos, Shiraishi Zapata, Carlos, Yanowsky-Gonzalez, Carlos, Sorrentino, Carmen, Tung, Carmen, Cardoso, Carolina, Chavarría Noya, Carolina, Coutinho, Carolina, Korzin, Carolina, Maya, Carolina, Moreno-Licea, Carolina, Panis, Carolina, Righetti, Carolina, Silva, Carolina, Soares-Aquino, Carolina, Golliez, Caroline, Chiam, Carolyn, Kamphues, Carsten, Rahantasoa Finaritra, Casimir Fp, Assis, Catarina, Henriques, Catarina, Quintela, Catarina, Rio Ferreira, Catarina, Rolo Santos, Catarina, Rodrigues, Catarina S., Allmer, Caterina, Bradshaw, Catherine Jane, Rukundo, Cédric, Seneza, Celestin, Raphael, Celine, Guldogan, Cem Emir, Bilir, Cemal, Hacıalioğlu, Cemal, Ersavas, Cenk, Özkan, Cenk, Huaroto Landeo, Cesar Fernando, Ginesta, Cesar, Infante, César, Pastás, César, Ciubotaru, Cezar, Narayan, Chanchal, Mahakalkar, Chandrashekhar, Floros, Charalampos, Demiri, Charikleia, Chatzinikolaou, Charito, Dempers, Charl, Ansah Larbi, Charles, Banka, Charles, Cini, Charles, Dally, Charles, Doku, Charles, Ntow-Boahen, Charles Kwaku, Nicholson Jr., Charles, Cornwell, Charlotte, Stennard, Charlotte, Lionel, Charre, Azmat, Chaudhary Ehtsham, Nyampinga, Chelsea, Tandup, Cherring, Agarwal, Chetan, Parmar, Chetan, Pun, Chetna, Un, Chi Wen, Baars, Chiara Anne, Celano, Chiara, Fumagalli, Chiara, Marafante, Chiara, Zandonella, Chiara, Nwanmah, Chibueze, Osuigwe, Chidimma, Nwokoro, Chigbundu, Nwosu, Chikaodili, Nwosu, Chimdiebele Daisy, Lim, Chin Kent, Ónyeka, Chinonso, Uche, Chisom, Jamieson-Grigg, Chloe, Ong, Chon Sum, Alphonse, Chris, Bode, Chris, Varghese, Chris, Carrillo Sarango, Christian, Esteo Verdu, Christian, Krautz, Christian, Mosca, Christian, Nimbona, Christian, Nikolaou, Christina, Wiesner, Christina, Kloppers, Christo, Kourouniotis, Christoforos, Seiler, Christoph, Knee, Christopha, Mpirimbanyi, Christophe, Aboah, Christopher, Amah, Christopher, Cheong, Christopher, Harmston, Christopher, Leung, Christopher, Seet, Christopher, Smart, Christopher, Chouliaras, Christos, Damaskos, Christos, Doudakmanis, Christos, Kaselas, Christos, Limas, Christos, Ntagkas, Christos, Papazacharias, Christos, Stefanou, Christos, Thrasyvoulou, Christos, Tsalikidis, Christos, Karagianni, Chrysanthi, Kolla, Chrysoula-Christina, Ugwunne, Chuka, Ilo, Chukwudi, Nwegbu, Chukwuemeka, Onwuzu, Chukwuka, Weadick, Ciara, De Martino, Ciro, Donohoe, Claire, Gutierrez De La Rosa, Clara Elena, Florián Villa, Clara Marcela, Petcu, Clara Teodora, Cecconi, Claudia, Banal, Claudine, Brandi, Claudio, Hossu, Claudiu, Onuoha, Clement, Osime, Clement, Shelton, Clifford, Fuentes Orozco, Clotilde, Adumah, Collins, Dina, Constantin, Nastos, Constantinos, Aguero, Coral, Markin, Coretta, Hoogerboord, Cornelis, Da Lio, Corrado, Saviello, Cosimo, Bezede, Cosmin, Distefano, Costanza, Elliot-Wilson, Courtney, Bokossa, Covalic, Lupercio Figueroa, Cristian Israel, Riboni, Cristiana, Meola, Cristiano, Costa, Cristina, Gas, Cristina, Larotonda, Cristina, Soddu, Cristina, Vacca, Cristina, Vera Mansilla, Cristina, Li, Crystal, Agbonrofo, Cynthia, Akli-Nartey, Cynthia, Molewa, Cynthia, Nelly Rosine, Cyuzuzo Ngwije, Rega, D., Koike, Daisuke, Wickramasinghe, Dakshitha, Clarke, Damian, Fry, Damian, Hannedige, Damsadie, Powell, Dan-Beck, Kasasbeh, Dana, Samardali, Dana, Sharl Ajami, Dani, Badran, Dania, Adjei, Daniel, Muhie, Daniel Ahmed, Pérez Muñoz, Daniel Alejandro, Alifoe, Daniel, Aparicio-López, Daniel, Baños Méndez, Daniel, Cristian, Daniel, Eaton, Daniel, Gero, Daniel, Makary, Daniel, Montwedi, Daniel, Muñoz, Daniel, Patterson, Daniel, Reim, Daniel, Agbley, Daniel Yao Dodzie, Patiño García, Daniela Cristina, Di Pietrantonio, Daniela, Pais, Daniela, Rosado, Daniela, Tavares, Daniela, Alberti, Daniele, Fusario, Daniele, Massaro, Daniele, Paglione, Daniele, Pironi, Daniele, Kurochka, Daniil, Centonze, Danilo Corrado, Hackner, Danilo, Herrera, Danilo, Amangaliyev, Daniyar, Silva-Cano, Danny Wladimir, Chaudhry, Daoud, Palmisano, Dario, Ribero, Dario, Vukosav, Dario, Misca, Darius, Lowen, Darren, Rattray, Darren, Walia, Darshanjit Singh, Maan, Darvesh, Muyenzi, Daryle, Verdi, Daunia, Bardsley, David, Reyes Rodríguez, David Estuardo, Fra Corral, David, Garcia López De Goicoechea, David, Gavit, David, Gómez, David, Idowu, David, Konkin, David, Labadah, David Kplorla Kekeli, Liu, David, Merlini, David, Mitchell, David, Moro-Valdezate, David, Osifo, David, Proud, David, Ridder, David, Gobatti, Davide, Muschitiello, Davide, Pertile, Davide, Zulian, Davide, Mengiste, Dawit, Mikami, Dean, Mohanty, Debajyoti, Chatterjee, Debarghya, Komolafe, Deborah Olaitan, Scotto Di Carlo, Deborah, Wright, Deborah, Rahme, Deema, Talreja, Deep Parkash, Jain, Deepak, Rajput, Deepak, Singh, Deepak, Anbu, Deepika, Ibrahim, Dena, Phom, Denchu, Hili, Denise, Osei, Dennis Broni, Daary, Dennis, Kyeremeh, Dennis, Shen, Dennis, Uymaz, Derya Salim, Cianflocca, Desiree, Ashitey, Desmond, Evripidou, Despo, Papageorgouli, Despoina, Kaushal, Devesh, Abeysirigunawardana, Dewmi, Dugar, Dharmendra, Mallik, Dhiraj, Ghosh, Dhruva, Houmran, Diaa, Abdulrahman, Diala, Pantoja Pachajoa, Diana Alejandra, Cardona Gomez, Diana Catalina, Fenner, Diana, Gonzalez, Diana Samantha, Siriwardena, Diana, Garcés Palacios, Diana Sofía, Stoian, Diana, Zuikyte, Diana, Sosa Méndez, Dianne Alitzá, Wickramarathna, Dickson, Mutter, Didier, Palma Portillo, Diego Andrés, Chavez Fernandez, Diego, Córdova García, Diego, Enjuto, Diego, Giulitti, Diego, Sasia, Diego, Visconti, Diego, Yiğit, Dilara, George, Dilip, Rabaia, Dima, Georgiev, Dimitar, Hadzhiev, Dimitar, Alexandrou, Dimitrios, Balalis, Dimitrios, Giakoustidis, Dimitrios, Manatakis, Dimitrios K., Korkolis, Dimitrios, Lytras, Dimitrios, Massaras, Dimitrios, Moris, Dimitrios, Politis, Dimitrios, Sampanis, Dimitrios, Schizas, Dimitrios, Tsiardas, Dimitrios, Vardakostas, Dimitrios, Kotsaris, Dimitris, Khattab, Dina Hesham, M. Awad, Dina, Alrokh, Dina Sami, Schippers, Dina, Waleed, Dina, Salinovic, Dinko, Gonçalves Múrias Gomes, Diogo Miguel, Silva, Diogo, Vaz Acosta, Diogo, Morton, Dion, Panagopoulos, Dionisios, Kelgiorgi, Dionysia, Dellaportas, Dionysios, Prevezanos, Dionysios, Joshi, Dipti, Ozal, Direm, Yigit, Direnc, Chimkaomasiri, Divine, Jabbar, Diya, Nepogodiev, Dmitri, Belekar, Dnyanesh, Abdalaziz, Doaa, Abunemer, Doaa, Attia, Doaa, Elkafrawy, Doaa, Dimitrov, Dobromir, Pignatelli, Domenica, Merlicco, Domenico, Soriero, Domenico, Zerbo, Domenico, Atouguia, Domingas, Fairbrass, Dominic, T. Enti, Donald, Venskutonis, Donatas, Rukavina, Dora, Caruso, Dorena, Herappe, Dorihela, Lee, Dorinda Norbetha, Ofosuhene, Doris, Hajela, Apoorva, Badwan, Basem, Kulkarni, Datta, Dhawan, Deep, Dhillon, Jeevanjit, Mehmood, Manzer, Mahmood, Namrah, Nikam, Narendra, Ramchandani, Radhakrishna, Thind, Ravinder Singh, Riazhussain, D Hafiz, Maqsood, Saliha, Alalawi, Yousef, Tyagi, Harshdeep, Kshirsagar, Shivani, Ahmed, Hisham, Juan Carlos, Luna Cydejko, Kone, Dramane, Omar, Duaa, Alves, Duarte Gil, Subasinghe, Duminda, Ommi, Durgesh, Joshiba, Durshney, Chakarov, Dzhevdet, Arkoh, Ebenezer Ameyaw, Frimpong-Manso, Ebenezer, Ada, Ece, Lincango, Eddy P., Lozada Hernandez, Edgard Efren, Hodžić, Edin, Di Marco, Edith, Baccalini, Edoardo Andrea, Baldini, Edoardo, González Marín, Eduardo, Gutierrez, Eduardo, Sepúlveda, Eduardo, Dainius, Edvinas, Zhang, Edward, Yenli, Edwin Mwintiereh Ta-Ang, Antoniou, Efstathios, Kapasakis, Efstathios, Baili, Efstratia, Poulios, Efthymios, Kubiliute, Egle, Osaze, Ehioghae, Afeikhena, Ehis, Elshennawy, Eiad, Athanasopoulou, Eirini, Synekidou, Eirini, Ekaladze, Eka, Tampaki, Ekaterini Christina, Adam, Elaf, Adel Hamdoun Aziz, Elaf, Yousuf, Elamin, Gialamas, Eleftherios, Spartalis, Eleftherios, Bedzhanyan, Elen, Toma, Elena Adelina, Daukšaitė, Elena, Desiato, Elena, Dvivedi, Elena, Hadzhieva, Elena, Martí Cuñat, Elena, Montalbán Martínez, Elena, Montanari, Elena, Signaroli, Elenasofia, Efremidou, Eleni, Gavriil, Eleni, Karakeke, Eleni, Mavrodimitraki, Eleni, Papamattheou, Eleni, Jose, Elenza, Cianci, Eleonora, Ciccioli, Eleonora, Daleva, Eleonora, Locci, Eleonora, Lori, Eleonora, Silanos, Eleonora, Ayala, Elí, Bankart, Eliana, Brolese, Eliane, Efstathiou, Elias, Salloum, Elias, Colak, Elif, Terzi, Elif Didem, Ametefe, Elikem, Cagigal Ortega, Elima Pilar, Donnarumma, Elio, Mina, Elisa, Reitano, Elisa, Wallner, Elisabeth, Moggia, Elisabetta, Betz, Elise, Kontis, Elissaios, Anestiadou, Elissavet, Gimson, Eliza, Lun, Elizabeth, Fraser, Elizabeth, Li, Elizabeth, Torres De Anda, Elizabeth Magaly, Murphy, Elizabeth Mary Ann, O'Connell, Elizabeth, Redondo, Elizabeth, Lun, Elizabeth Weng Yan, Francis, Ella, Haiden, Elmar, Hamed, Elmonzir, Alkhalifa, Elmustafa, Dexter, Eloise, Daketsey, Elorm, Setsoafia, Elorm, Mohamed, Elsagad, Mohammed, Elsamoual, Hegab, Elsayed, Ay, Elvin, Adinolfi, Elvira, Mbanzabugabo, Elvis, Chin, Elynn, Ahmed, Emad Ali, Younes, Eman, Basile, Emanuela, Gessa, Emanuela, Pontecorvi, Emanuele, Romairone, Emanuele, Hatangimana, Eméry, Ndizeye, Emile, Ciofic, Emilia, Dijan, Emilio, López-Negrete Cueto, Emilio, Baker, Emily, Reid, Emily, Schmidt, Emily, Alić, Emir, Bičakčić, Emir, Agbowada, Emma, Colton, Emma, Downing, Emma, Haege, Emma, O'Neill, Emma, Roussos, Emmanouel, Nachelleh, Emmanuel Aadereyir, Adebunmi, Emmanuel, Obiesie, Emmanuel Ahuizechukwu, Akakpo, Emmanuel Bismark, Konlan, Emmanuel Dammigu Francis, Nwangwu, Emmanuel Ifeanyi, Kafui Ayodeji, Emmanuel, Ofori, Emmanuel Owusu, Spanoudakis, Emmanuel, Abate, Emmanuele, Balik, Emre, Bozdağ, Emre, Bozkurt, Emre, Karabulut, Emre Cagri, Ozoran, Emre, Tunçcan, Emre, Tuzuner, Emre, Halilović, Emsad, Alabed, Enaam, Zidan, Enas, Hodžić, Enes, Aybar, Engin, Yildirim, Engin Okan, Wong, Enoch, Yhoshu, Enono, Bisogno, Enrica, Andolfi, Enrico, Ferri, Enrico, Potenza, Enrico, Spalice, Enrico, Volpin, Enrico, González, Enrique, Downes, Eoin, Gallo, Erdachew, Kamer, Erdinc, Naidoo, Eressa, Erginöz, Ergin, Bara, Eric, Irungu, Eric, García-Villegas, Eric Yusif, Mazzotta, Erica, Monati, Erica, Chan, Erick, Gómez Mejía, Erika, Dylja, Eris, Somuncu, Erkan, Yavuz, Erkan, Begunić, Ernes, Margelis, Ernest, Osei, Ernest Owusu, Saitoglou, Ertzan, Agastra, Ervis, Mazumdar, Eshan, Soyer Güldoğan, Esra, Abu Siam, Esra'A, Abdelbaset, Esraa, Abdu, Esraa, Adel Mahmod Sultan, Esraa, Nubi Mohamed, Esraa Gamal, Abuobaida Banaga Hag El Tayeb, Essam Eldien, Ali, Essraa, Page-Taylor, Estelle, Marra, Ester, Garcia Santos, Esther Pilar, Elsheikh, Ethar, Unal, Ethem, Tan, Eugene, De Leo, Eugenio, Borges, Eva, Gáspár, Éva, Ruiz-Daum, Eva, Apostolopoulos, Evaggelos, Samara, Evangelia, Barkolias, Evangelos, Fradelos, Evangelos, Hopping, Eve, Romo Ascencio, Evelia Veronica, Sosa Ferreira, Ever David, Shestakov, Evgenii, Tyurina, Evgenya, Hristova, Evguenia, Efthymiou, Evripidis, Tokidis, Evripidis, Harrison, Ewen, Dontoh, Ewurama Akroma, Mansour, Eyad, Yeshialem, Eyosiyas, Dabbagh, Ezeddin, Amer, Ezzeldin, Manasci, Fabiana, Gomes, Fabio, Medas, Fabio, d'Acapito, Fabrizio, Vassallo, Fabrizio, Haddad, Fadi, Elhabishi, Fadwa, Akhtar, Fahad, Tauheed, Fahad, Al Abbood, Fahd, Gareb, Fahed, Ghazali, Fairuz, Alnazawi, Faisal, Ondago, Faith, Rasoaherinomenjanahary, Fanjandrainy, Wiese, Fanny, González Ponce, Fanny Yesenia, Georgiades, Fanourios, Ali, Farah, Galley, Fareeda, Huda, Farhanul, Amir, Farhat Naaz, Ashraf, Fariha, Alfarsi, Faris, Ayasra, Faris, Ali, Farman, Mahmoud, Faten, Aliskander, Fater, Tahir Lwdie, Fathea, Buyuker, Fatih, Aguilar Del Castillo, Fátima, Mohammed Daoud, Fatima Ahmed, Alowjaly, Fatima, Oni, Fatima, Rauf, Fatima, Elkhafeefi, Fatimah, Hourri, Fatine, Monib, Fatma A., Alshreef, Fatma, Benghalbon, Fatma, Ntirenganya, Faustin, Ashraf, Fauziyah, Chahrour, Fayez, Ahmad, Fazal, Parray, Fazlul Qadir, Philips, Febi, Campus, Federica, Di Marco, Federica, Ferraina, Federica, Frongia, Federica, Maffeis, Federica, Natali, Federica, Pederiva, Federica, Scolari, Federica, Tofani, Federica, Marin, Federico Alberto Niccolò, Biolchini, Federico, Cappellacci, Federico, Corronca, Federico, Mazzola, Federico, Suldrup, Federico, Nyarko, Felicia, Casas J, Felipe, Zapata, Felipe, Aigner, Felix, Alakaloko, Felix, Amoako, Felix, Camacho, Felix, Hammett, Felix, Kuubetersob B. N, Felix, Alahmad, Feras, Alnimri, Feras, Haddad, Feras, Gool, Ferhana, Castro, Fernanda, Diaz, Fernanda, Lucero, Fernanda, Vovola, Fernanda, Mahnic, Fernando, Mercado Sanchez, Fernando, Prieto La Noire, Fernando, Soggiu, Fiammetta, Tsige, Fikreab, Brzeszczyński, Filip, Rudisch, Filip, Valente Costa Pinto, Filipa, Ramalho De Almeida, Filipe, Banchini, Filippo, Palomino Escalante, Fiorella, Fadzlullah, Fitri, Terefe, Fitsum, Sulo, Fjorenta, Ciccarone, Flavia, Tirelli, Flavio, Krämer, Florian, Grama, Florin, Spanos, Foivos, Solimene, Folco, Akinwande, Foluso, Osman, Forzia, Stefou, Foteini, Kyramargios, Fotios, Stavratis, Fotios, Alassani, Fousseni, Ascari, Francesca, Cammelli, Francesca, D'Agostino, Francesca, Tropeano, Francesca Paola, Peters, Francesca, Ré, Francesca, Brucchi, Francesco, Casti, Francesco, Coratti, Francesco, Ferrara, Francesco, Floris, Francesco, Izzo, Francesco, Maffei, Francesco, Palmieri, Francesco, Pata, Francesco, Porcelli, Francesco, Selvaggi, Francesco, Velluti, Francesco, Mulita, Francesk, Bello, Francis, Caiquo, Francis, Dossou, Francis, Eshun, Francis Junior, Opoku Twene, Francis, Tierenye, Francis, Quayson, Francis William, Romo Rosales, Francisco David, Ibañez Ortiz, Francisco, León Frutos, Francisco Javier, Redondo Calvo, Francisco Javier, Silva Rivera, Francisco Javier, Barbosa Camacho, Francisco José, Bujalance Cabrera, Francisco Manuel, Ruescas, Francisco, Irakiza, Franck Fanon, Corvatta, Franco, Pascual, Franco Raúl, Roviello, Franco, Roodt, Francois, Gyamfi, Frank Enoch, Olaniru, Frank, Owusu, Frank, Bader, Franz G., Anzinger, Franz-Xaver, Agbodo, Fred David Anku, Ris, Frederic, Agbemafoh, Frederick Mawuli, Afonso, Frederico, Nazareth, Frederico, Berrevoet, Frederik, Hounde, Fréjus, Demiral, Furkan, Hassooni, Furqan Ridha Hassooni, Kafa, Gabi, Cárdenas Rivera, Gabriel, Ntwari, Gabriel, Szydlo Shein, Gabriel, Ambriz González, Gabriela, Nita, Gabriela Elisa, Bellio, Gabriele, Moitzi, Gabriele, Urdang, Gabriella, Marom, Gad, Gallo, Gaetano, Luglio, Gaetano, Poillucci, Gaetano, Singh, Gagandeep, Saletta, Gaia, Abouelnagah, Galal, Yarovenko, Galina, Kazobinka, Gallina, Ahmed, Gamal Mutwakil Gamal, Rahman, Ganiyu Adebisi, Smith, Garett, Pillai, Gargi, Saxena, Garima, Gbessi, Gaspard, Nkunguzi, Gaston, Jalal, Gaurav, Chillarge, Gauri, Singh, Gautam, Mevognon, Gedeon, Getachew, Gedion, George, Gejoe, De La Peña González, Gema, Martínez Izquierdo, Gema, Grande, Gennaro, Birikorang, Geoffrey, Weber, Georg F., Singer, Georg, Ansong, George, Bashour, George, Brown, George Darko, Hneino, George, Kavalieratos, George, Kenchadze, George, Nagy, George, Pappas Gogos, George, Skroubis, George, Waiyaki, George, Cox, Georgia, Zeringa, Georgia, De Wee, Georgin, Hart, Georgina, Bekakos, Georgios, Fragulidis, Georgios, Kapogiannatos, Georgios, Karakaidos, Georgios, Kokkinos, Georgios, Kostoulas, Georgios, Koukoulis, Georgios, Peros, Georgios, Rados, Georgios, Tsoulfas, Georgios, Verras, Georgios-Ioannis, Berger, Geraint, Adoro, Gerard Ayuka, Chamoso Mialdea, Gerardo, Palmieri, Gerardo, Procaccini, Gerardo, Steenkamp, Gerhard, Viscido, Germán Rodrigo, Dajti, Gerti, Alemayehu, Getachew, Seyfu, Gezachew, Birqeeq, Ghada, Alsheikh, Ghadeer, Alrayyes, Ghaith, El Hunjul, Ghalib Nashaat, Zaza, Ghayath, Matroud, Ghazlah, Alhadwah, Ghena, Maltinti, Gherardo, Awais, Ghina, Shamsi, Ghina, Calini, Giacomo, Carganico, Giacomo, Zanus, Giacomo, Canu, Gian Luigi, Mendiola, Gian, Ibero Casadiego, Giana Pamela, Cocorullo, Gianfranco, Baronio, Gianluca, Pellino, Gianluca, Zanni, Gianluca, Poto, Gianmario Edoardo, Gravante, Gianpiero, Aduroja, Gideon, Almogy, Gidon, Bond-Smith, Giles, Natchagande, Gilles, Bechara, Gio, Brachini, Gioia, Riccioli, Giordana, Ercolani, Giorgio, Farris, Giorgio, Giraudo, Giorgio, Mammolo, Giovanna, Pavone, Giovanna, Sgarzini, Giovanna, Aprea, Giovanni, Fonsi, Giovanni Battista, Boroni, Giovanni, De Angeli, Giovanni, De Palma, Giovanni Domenico, Emiliani, Giovanni, Grava, Giovanni, Guercio, Giovanni, De Carlo, Giulia, Del Corpo, Giulia, Duranti, Giulia, Galatioto, Giulia, Grassi, Giulia, Graziano, Giulia, Marini, Giulia Maria Francesca, Munzi, Giulia, Tarantino, Giulia, Borda-Luque, Giuliano, Pellicano', Giuseppe Antonino, Canonico, Giuseppe, Carollo, Giuseppe, Ietto, Giuseppe, Palomba, Giuseppe, Pascarella, Giuseppe, Salamone, Giuseppe, Sica, Giuseppe, Sorrentino, Giuseppe, Orlando, Giuseppina, Pignata, Giusto, Pisarevi, Givi, Akcakoca, Gizem, Owusu, Godfred, Yohanna Abrak, Godwin, Kurtoglu, Gokalp Kagan, Kurtoglugk, Gokalp Kagan, Alıcı, Gökhan, Kurtoglu, Goktug Mert, Delgado Hernandez, Gonzalo, Augustin, Goran, Bhat, Gowhar Aziz, Sundaram Venkatesan, Gowtham, Chang, Grace, Eke, Grace, Lee, Grace, Massarra, Grace, Travaglini, Grazia, Scialandrone, Grazisa, Stavrou, Gregor A., Di Franco, Gregorio, Charalambous, Gregory, Christodoulidis, Gregory, Kouraklis, Gregory, Goodwin, Gregory Richard, Devidze, Grigol, Fialho, Guilherme, Santos, Guilherme, Cabezudo, Guillermo, García-Santos, Guillermo, Pou, Guillermo, Romero Reyna, Guillermo, Yanowsky-Reyes, Guillermo, Ozyuksel, Gul, Karadeniz Cakmak, Guldeniz, Kucuk, Gultekin Ozan, Bulbuloglu, Guney Cem, Sarp, Guray, Kaur, Gurleen, Nibogora, Guy Darcy, Hamdan, Gymar, Ogundipe, Habeeb, Yunes, Habib, Ayesh, Hadeel, Al Atassi, Hadi, Jalilehvand, Hadis, Masalma, Hafez, Jafarkhan, Hafis, Shahid, Hafiz Huzaifa, Younus, Hafsa, Al-Derume, Hail, Shames, Haitam, Mimouni, Haithem Ahmed, Aldare, Hajar, Odah Bashi, Hajar Omar, Abusnina, Hajer, Altounsi, Hajir, Qayum, Hajra, Baysal, Hakan, Bolukbasi, Hakan, Yigitbas, Hakan, Alkhatib, Hala, Afzal, Haleema, Mftah, Halima, Oyinlola, Halimah, Tümer, Haluk, Dolo, Hamadoun, Braham, Hamdi, Ozsahin, Hamdi, Abu-Arish, Hamdoon, Al-Aamri, Hamed, Fadlalmola, Hammad Ali, Abu Obead, Hamza, Al-Fahel, Hamza, Al-Zoubi, Hamza, Asaad, Hamza, Ejaz, Hamza, Jaber, Hamza, Bhatti, Hamza Waqar, Mohammadi Sardoo, Hamzeh, Farhat, Hana, Idheiraj, Hanadi, Zwaraa, Hanady, Al Sohabi, Hanan, Basharat, 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Özata, ıbrahim Halil, Kandil, Ibrahim, Ahmed, Ibrahim Mutwakil Gamal, Tagreda, Ibrahim, Garzali, Ibrahim Umar, Nadi, Ibtihal, Ogundele, Ibukunolu, Pius Ogolekwu, Idoko, Shariff, Idriss, Jakaityte, Ieva, Abdullah, Ifra, Babajimi-Joseph, Igbagbolere, Guirguis, Ihab, Orji, Iheanyi, Okoro, Iheanyichukwu, Ahmed, Ihsan, Obianyo, Ijeoma, Njere, Ike, Ugwueke, Ikechukwu, Nzenwa, Ikemsinachi C, Zerrouq, Ikram, Clementi, Ilaria, Neri, Ilaria, Yavuz, Ilayda Esma, Hoxhaj, Ilda, Fakhradiyev, Ildar, R Fakhradiyev, Ildar, Gomatos, Ilias, Fidoshev, Iliya, Gouazar, Iltimass, Alnimer, Imad, Boudis, Imad Eddine, Boumakhlouf, Imad Eddine, Abdalla, Iman, Herrero, Imanol, Osman, Imoro, Nasser, Inas, Singh, Indra, P S, Induchoodan, Borges Da Costa, Inês, Colaço, Ines, Lourenço, Inês Mariana, Mogárrio, Inês, Königsrainer, Ingmar, Ahmed, Intezar, Hamdun, Intisar Hisham Said, Tanase, Ioan, Bokos, Ioannis, Contis, Ioannis, Demiris, Ioannis, Gerogiannis, Ioannis, Gogoulis, Ioannis, Karatsolis, Ioannis, Katsaros, Ioannis, Kozadinos, Ioannis, Margaris, Ioannis, Maroulis, Ioannis, Papaconstantinou, Ioannis, Siannis, Ioannis, Sougkas, Ioannis, Spyridakis, Ioannis, Tierris, Ioannis, Tsakiridis, Ioannis, Imihteev, Ion, Negoi, Ionut, Chatzis, Iosif, Shahbaz, Iqra, Didier, Irabishohoje, Pipia, Irakli, Parwaiz, Iram, Durán Sánchez, Iran Irani, Norman, Irena, Bakaweri, Irenaeus Nutumie, Santos, Irene, Mylona, Irene Chrysovalanto, De Haro Jorge, Irene, Cervera, Iria, Dajti, Irida, Datji, Irida, Matache, Irina Mihaela, Russo, Iris Shari, Aremu, Is'haq Ishola, Amankwaa, Isaac, Caitens, Isaac, Esparza Estrada, Isaac, Mubezi, Isaac, Gascon Ferrer, Isabel, Serrano, Isabel, Dong, Isabella, Mondi, Isabella, Serfontein, Isabella, Rakshit, Ishani, Kyei, Ishmael, Murshed, Ishraq, Cabrera, Ishtar, Abo Elhagag, Islam, Alsoubie, Ismael, Lawani, Ismail, Bilgin, Ismail Ahmet, Cholah, Ismail, Hamzaoglu, Ismail, Lawani, Ismaïl, Maharem, Israa, Shehadeh, Israa, Hagbevor, Israel, Bahikoro, Issa Wendpouiré, Laopeamthong, Issaree, Mikulic, Iva, Bacic, Ivan, Rakvin, Ivan, Separovic, Ivan, Vidić, Ivan, Conversano, Ivana, Mrazkova, Ivana, Yotsov, Ivelin, Ilieva, Ivelina, Ćoza, Ivo, Ali, Iyad, Aljada, Iyad, Hussein, Iyad, Tesfahun, Iyasu, Sadiq, Izzah, Martinez Martin Del Campo, J Francisco, Mackenzie, Jack, Maida, Jack Vittorio, Kaippally, Jacob, Montero García, Jacobo, Andreuccetti, Jacopo, Martellucci, Jacopo, Secchi, Jacopo, Van Niekerk, Jacques, Saunders, Jada, Duffield, Jaime A., Tavares-Ortega, Jaime Alberto, Orozco-Perez, Jaime, Mihanovic, Jakov, Woleský, Jakub, Bryan, James, Bundred, James, Cui, James, Glasbey, James, Casella Mariolo, James Rossario, Suliman, Jamil, Mohammad Mohammad, Jamiu, Bolanowski, Jan, Goedeke, Jan, Grosek, Jan, Moravik, Jan, Ringers, Jan, Roman, Jan, Chew, Janae, Maritz, Jancke, Martin, Janet, Velkoski, Jaqueline, Wong, Jason, García-Quijada, Javier, Tk, Jayakumar, Siby, Jayas, Mcnab-Hand, Jaymee, Gusa, JB, Gusa, Jean Bosco, Allen, Jean Claude, Mbonicura, Jean Claude, Rugambwa, Jean Paul, Jordaan, Jean- Jacques, Razafindrahita, Jeannie Ba, Do, Jee Eun, Senavirathna, Jeewantha, Kalyanapu, Jeffrey A, Chan, Jeffrey, Ofori, Jeffrey, Otote, Jeffrey, Akiely, Jehad, Cassiano Neves, Jelena, Gillingham, Jemima, Herrera Batres, Jenifer Olga María, Ezeh, Jennifer, Okei, Jennifer, Vu, Jennifer, Guevara, Jenny, Siu, Jenny, Rolinger, Jens, Skaff, Jeolle, Uys, Jernelle, Makama, Jerry Godfrey, Barklimore, Jessica, Dei-Asamoa, Jessica, Jahjah, Jessica, Jones, Jessica, Ng, Jessica, Ricardo, Jéssica, Schembri Higgans, Jessica, You, Jessica, Annan, Jessie, Aguilar, Jesus Antonio, Pizarro Lozano, Jesús, Lim, Jia Hui, Zhu, Jiang, Wang, Jianxue, Abbasy, Jibran, Ugwu, Jideofor, Rathod, Jignesh, Albalushi, Jihan, Najajra, Jinan, Fu, Jing Hui, Tefay, Joan Sia Tan, Domingues, Joana Cristina, Simoes, Joana FF, Figueiredo, Joana, Fontaínhas, Joana, Frazão, Joana, Marques Antunes, Joana, Simoes, Joana, Marx, Joanna Naemi, Dias-Ferreira, João, Fernandes, João, Mendes, João, Pinho, João, Ribeiro, João, Vaz, João, Dominguez, Joaquina, Abutu John, Job, Chen, Joe Jun Qiao, Enaholo, Joel, Alaji, Joelle, Miller, Johanna, Binder, Johannes, Daleku, John, Katogiritis, John, Khoury, John, Anyorigiya, John Noah, Reilly, John, Abebrese, John Tabiri, Ahale, Johnny Lordson, Tabora-Zepeda, Johnny, Barrutia Leonardo, Jon, Demma, Jonathan Abraham, Hong, Jonathan, Chejfec-Ciociano, Jonathan Matias, Oppong, Jonathan, Quansah, Jonathan, Sutcliffe, Jonathan, Taiwo, Jones, Nyamekye - Baidoo, Joojo, Prat-Ortells, Jordi, Dongmo, Jordy, Kleeff, Jorg, Jimenez Flores, Jorge Alberto, Pellecer Cano, Jorge Bernardo, Chóliz, Jorge, Giubi Bobeda, Jorge Eduardo, Escartin, Jorge, Febré, Jorge, Gass, Jörn-Markus, Calvache, Jose A, Guzman Barba, Jose Aldo, Gutiérrez Gómez, José Alonso, Calvache, Jose Andres, Acevedo Parrales, José Danilo, Orozco Navarro, José Esteban, Viñas, José Federico, Gomez, José, Goncalves-Nobre, Jose Guilherme, Valenzuela, José Ignacio, Garcia Galocha, Jose Luis, Rodicio Miravalles, Jose Luis, Faylona, Jose Macario, Alvarez Hernandez, Jose Manuel, De Francisco Rios, Jose Mario, Martin Fernandez, Jose, Michel, José, Carlos, José Miguel, Mondino, Jose, Vieira De Sousa, José Pedro, Asturias Luna, José Rodrigo, Hernández, Jose Rodrigo, García, José Sebastian, Galea, Joseph, Hwang, Joseph, Leong, Joseph, Yorke, Joseph, Psaila, Josephine, Walshaw, Josephine, Ampadu, Joshua, Linker, Joshua, Ng-Kamstra, Joshua, Olorunfunmi, Joshua, Mavrek, Josip, Miskovic, Josip, Petric, Josipa, Avakoudjo, Josue, Al Karmi, Joud, Fahed, Joud, Suleiman Hadidi, Joudd, Alkharish, Joul, Juloski, Jovan, Vaitekūnas, Jovydas, Wang, Joyce, Flores Prado, Juan Armando, Beltrán De Heredia, Juan, Garcia Vera, Juan Carlos, Molina Marin, Juan David, Gonzalez Aboytes, Juan Eduardo, Ulloa Robles, Juan Jose, Blas Laina, Juan Luis, Carranza Rosales, Juan Manuel, Morales, Juan, Naranjo Fernández, Juan Ramón, Al Daradkah, Jude, Aseme, Jude, Ede, Jude, Kahn, Judith, Lindert, Judith, Deeb, Judy, Mühlhäusser, Julia, Sidorovskaia, Julia, Carrizo, Julian, Napoli, Juliana, Pereira-Macedo, Juliana, Ribeiro, Juliana, De Deken, Julie, Nnoli, Juliet, Paredes, Julieta, Zevallos-Quiroz, Julio Cesar, Gonzalez Garcia, Julio, Adjei, Julius, Olaogun, Julius, Kutkevičius, Juozas, Metzger, Jürg, Košir, Jurij Aleš, Kosir, Jurij, Seyi-Olajide, Justina, Zajac, Justyna Karolina, Dhima, Jyoti, Dhiman, Jyoti, Shreyas, K, Türker, Kadir Yağız, Lee, Kai, Khutsishvili, Kakhi, Yu, Kam Keung Auston, Das, Kamala, Özdoğan, Kamil, Reddy, Kamireddy Madana Raghava, Kabulov, Kamran, Nahar, Kamrun, Rajaratnam, Kanapathippillai, Wijesinghe, Kanchana, Sevnaran, Kapil, Khalil, Karam, Singh, Karanbir, Fayed, Kareem, Booyse, Karien, Geiger-Timm, Karin, Maharaj, Karl, Bhutia, Karma, Richter, Karolina, Komorowska, Katarzyna, Urbańska, Katarzyna, Waddell, Kate, Kambouri, Katerina, Tata, Katerina, Richetti, Katharina, Griffin, Katherine, McKenzie, Katherine, Tambudze, Katherine, Hall, Katheryn, Chu, Kathryn, Theodoropoulou, Katina, Kröning, Katrin, Bozada-Gutiérrez, Katya, Raghuwanshi, Kaustubh, J B, Kavitha, Ahmed Ibrahim, Kefah, Bwala, Kefas John, Iles, Kelly, Jasso García, Kelvin, Oğur, Kemal, Fretwell, Kenneth, Oluchukwu, Kenneth, Onyekachi, Kenneth, Voon, Kenneth, Oderoha, Kevin Ewomazino, Nieto Yrigoin, Kevin, Quispe De La Roca, Kewin, Anaam, Khadega, Bensmain, Khadija, Shwail, Khadija, Akter, Khadiza, Sawaftah, Khaled Ahmad, Shamiyah, Khalid Adnan, Bhatti, Khalid, Mohammed, Khalid Miftah Ghuraybeel, Ayyoub, Khalil, Cholah, Khalil, Rahman, Khandakar Rezwanur, Abdulrahman, Khawla, Al-Shami, Khayry, Hayat, Khizar, Al Hinai, Khulood, Taghavi, Kiarash, Shodunke, Kikelomo, Abo Zaal, Kinaz, Ewool, Kingsley, Gaikwad, Kiran, Shemyatovsky, Kirill, Dey, Kirsty Elaine, Mishra, Kirti Kumar, Rathod, Kirtikumar J, Senanayake, Kithsiri Janakantha, Noguchi, Kiyonari, Kordeni, Kleoniki C., Dembele, Klétigui Samuel, Spassov, Kolyo, Khalid, Komal, Petrenko, Konstantin, Bekiaridou, Konstantina, Rekouna, Konstantina, Athanassiou, Konstantinos, Avgerinos, Konstantinos, Bouchagier, Konstantinos, Bouliaris, Konstantinos, Bramis, Konstantinos, Iliakopoulos, Konstantinos, Kontzoglou, Konstantinos, Ntatsis, Konstantinos, Pavlopoulos, Konstantinos, Perivoliotis, Konstantinos, Polychronopoulos, Konstantinos, Giannakopoulos, Konstantinos S., Zakkas, Konstantinos, Zapsalis, Konstantinos, Koumarelas, Konstantinos-Eleftherios, Mori, Krinal, Ooi, Krisada, Ascencio Diaz, Kriscia Vanessa, Jasaitis, Kristijonas, Nieuwenhuys, Kristin, Atherton, Kristy, Smith, Kristy, Sharma, Kruti, Jaffry, Kumail, Lehmann, Kuno, Ayad, Kusay, Luthra, Kush Kumar, Nanayakkara, Kushan, Agbedinu, Kwabena, Oduro-Boateng, Kwaku Boakye, Boakye-Acheampong, Kwame, Sim, Kwang Kiat, Yalley, Kwekuma, Collins, Kyeremeh, Muscat, Kyle, Hofmann, Kyra, Lambri, Kyriaki, Bananis, Kyriakos, Nassim, Kyrillos, Allan, Lachlan, Codina Corrons, Laia, Hijazein, Laith, Moolla, Laith, Sweidan, Laith, Rai, Lajpat, Devi, Lakshmi, Fountoulis, Lampros, Andreski, Lara, Bonello, Lara, Rodrigues Madeira, Lara, Tafesh, Lara, Yasin, Lara, Martinez, Laura, Fortuna, Laura, Peña Balboa, Laura Gabriela, García-Zambrano, Laura, Bolaños, Laura Isabela, Jiménez, Laura, Lely, Laura, Ortega Lechuga, Laura, Rossi, Laura, Rubin, Laura, Ruiz-Villa, Laura, Sequi, Laura, Sahan, Laura-Ann, Johnstone, Lauren, Monteiro, Lauren, Abdullahi, Lawal Barau, Jovcheski, Lazo, Siragusa, Leandro, Kang, Leannedra, Elgebaly, Leenah, Mansour, Lefteris, Robine-Durnell, Lélia, Bray, Lemuel Davies, Mohammed, Lena, Licari, Leo, Onyebulu, Leonard, Chieng, Leonard Ron, Solaini, Leonardo, Chardalias, Leonidas, Fountarlis, Leonidas Ilias, Van Den Hil, Leontine, Tapia Moral, Leopoldo, Petashvili, Leri, Heeren, Letícia, Laface, Letizia, Niyidukunda, Lewis, Barnard, Liam, Torres Bavestrello, Lidice Veronica, Hasan, Lilav, Dyab, Lima, Venclauskas, Linas, Beukes, Linda, Gabellini, Linda, Liepa, Linda, Zeng, Lingjuan, Dubs, Linus, Rampersad, Lisa, Catozzi, Livio, Castro, Lizeth, Milic, Ljiljana, Shawesh, Lobna, Anyanwu, Lofty-John, Khalifa, Lojina, Cheng, Lok Pong, Manoj Joshua, Lokavarapu, Shammas, Lora, Fuentes Rivera Lau, Lorena, Rodríguez Gómez, Lorena, Capello, Lorenzo, Epis, Lorenzo, Fatucchi, Lorenzo Maria, Rende, Lorenzo, Ripamonti, Lorenzo, Ackam, Louis, Moniz, Lourenço, Bains, Lovenish, Alriyami, Lubna, Alokshi, Lubnah, Martinek, Lubomir, Tulinsky, Lubomir, Samison, Luc, Lo Piccolo, Luca Benedetto, Cardinali, Luca, Nespoli, Luca Carlo, Casingena, Luca, Degrate, Luca, Bonomo, Luca Domenico, Morelli, Luca, Ottaviani, Luca, Resca, Luca, Scaravilli, Luca, Schiavone, Luca, Theuil, Luca, Casalduero, Lucas, Lee, Lucas D., Granero, Lucas, Caram, Lucas Jose, Barni, Lucia, Cidade Costa, Luciana, Paredes, Luciana, Poggi, Luciano, Marquez, Lucila, Garciandia, Lucio, Taglietti, Lucio, Pramod, Ludiya, Stella, Ludovica, Carbone, Ludovico, Bracciano, Luigi, Cobellis, Luigi, Conti, Luigi, Fedele, Luigi, Ragazzini, Luigi, Simonelli, Luigi, Verre, Luigi, Flores Chávez, Luis Adrián, Rea Bocanegra, Luis Alberto, Pelayo Orozco, Luis Ángel, Asensio Gomez, Luis, Bravo, Luis, Flores Chávez, Luis Manuel, Poggi, Luis, Cabezudo, Luis Ramón, Sante Serna, Luis, Tallon-Aguilar, Luis, Talé-Rosales, Luis-Fernando, Chantada, Luisa, Moreira, Luísa, Hasan, Lujain, M Mheidat, Lujain, Eisner, Lukas, Gantner, Lukas, Havranek, Lukas, Majerčák, Lukáš, Pánči, Lukáš, Nawacki, Łukasz, Adagrah Aniakwo, Luke, Bromley, Luke, Green, Luke, Paterson, Luke, Peters, Luke, Abdur-Rahman, Lukman, Omomeji, Lukman, Amosu, Lukmon, Kolongi, Lungushinga Christopher, Bin Aizan, Luqman Naim, Imchen, Lurong, Chang, Lydia, Mukamazera, Lydie, Katsiaras, Lykoyrgos, Al-Boukhari, Lynn, Chong, Lynn, Karydakis, Lysandros, Peris, M. Roosindu, Cancelas, Mª Dolores, Kariem, Maahir, Amoako-Boateng, Mabel, Alshamikh, Mabroukah, Ishak, Mabruok, Narayanan, Machingal, Matyja, Maciej, Walędziak, Maciej, Zounon, Mack-Arthur, Trindade, Madalena, Shahid, Madeeha, Kelly, Madeleine, Bajwa, Madiha, Bowles, Madison, Roussos, Madison, Sampaio-Alves, Mafalda, Manfredini, Magda, Kołomańska, Magdalena, Redynk, Magdalena, Farooq, Maham, Ali, Mahamudu Ayamba, Rodha, Mahaveer Singh, Alsalawi, Mahdi, Lodha, Mahendra, Sethi, Mahesh Kumar, Khalil, Mahfoud, Singh, Mahima, Abdualqader, Mahmmoud yehia, Abdelhafez, Mahmood, Sersarah, Mahmood, Abdelreheem, Mahmoud, Abu Al Amrain, Mahmoud, Barbarawi, Mahmoud, Diab, Mahmoud, Eissa, Mahmoud, ElFiky, Mahmoud, Elmesalmi, Mahmoud, Elmousili, Mahmoud, Fahmy, Mahmoud, Faisal, Mahmoud, Jabal, Mahmoud, Saad, Mahmoud M., Mahafdah, Mahmoud, Marei, Mahmoud Marei Abdelaziz, Mostafa, Mahmoud, Reda, Mahmoud, Zahran, Mahmoud, Suleman, Mahmowd, Genç, Mahmut Salih, Haghighat Ghahfarokhi, Mahta, Abubakar, Maimuna, Haimona, Mairarangi, Camuera, Maite, H. Oweidat, Majd, Mansour, Majd, Kalabić, Majda, MohammedAli, Majdeddin, Abu Daoud, Majdi, Almahjoub, Majdolin, Bilfaqirah, Majed, Yigah, Makafui, Akkawe, Malak, Dery, Malcolm, West, Malcolm, Rius, Malena, Nandasena, Malith, Aljarawn, Mallak, Masaaod, Mallak, Manangi, Mallikarjuna, Windsouri, Mamadou, Battili, Mamata, Rakotonaivo, Mamisoa Judicaël, Benghazi, Manaji, Al-Dhaheri, Manal, Almaqrahi, Manal, Katif, Manal, Alshami, Manar, Ibrahim, Manar, Ramazanov, Manas, Kaur, Mandeep, Agrawal, Manish Kumar, Pathak, Manish, Aggarwal, Manisha, Chandrasegaram, Manju, Anandan, Manoj, K S D, Manoj Kishan Lal, Kumar, Manoj, Sarda, Manoj, K B, Manojkumar, Jokubauskas, Mantas, Moreno Gonzales, Manuel Arturo, Cruz, Manuel, Diez Alonso, Manuel, Garcia, Manuel, Perez, Manuel, Mosquera Paz, Manuel Santiago, Cammelli, Manuela, Mercurio, Manuela, Singh, Manvinder, Taamreh, Manwa, Canals Sin, Mªpilar, Carbonell Pradas, Mar, Nunes, Mara, Sawaftah, Marah Ahmad, Khalil, Maram, Schneider, Marcel André, Steffani, Marcella, Pisano, Marcello, Doniquian, Marcelo Alejandro, Martínez Bareiro, Marcelo Nicolás, Pagani, Marcelo, Scortechini, Marcelo, Carvalho, Márcia, Sánchez Audelo, Marco Antonio, Brizzolari, Marco, Ceresoli, Marco, De Prizio, Marco, Amisano, Marco Francesco, Gramellini, Marco, Marcianò, Marco, Mariani, Marco, Milone, Marco, Montagna, Marco, Piccino, Marco, Santos, Marco, Dyer, Marcus, Kang, Marcus, Mahadi, Mardhiana, Zawadzki, Marek, Yinusa, Margaret, Bernardo, Margarida, Nunes Luís, Margarida, Gambelli, Margherita, Flint, Margot, Aggelidou, Maria, Bequis, Maria Agustina, Sotiriou, Maria Aikaterini, Ñañez, Maria Alejandra, Tahir, Maria Ambreen, Gascón Domínguez, María Ángeles, Asimakidou, Maria, Mourato, Maria Beatriz, Blanco, Maria, Christou, Maria, Coronas Soucheiron, Maria, Pignanelli, Maria Costanza, Kalaydjian, María Cristina, Martí-Ejarque, Maria del Mar, Olmedo Reinoso, María Del Mar, Cebollero, María Del Pilar, Derattani, Maria, Gama Caldeira, Maria Do Carmo, Drogouti, Maria, Gonzalez-Gonzalez, Maria Elena, Muñoz Fernández, María Elena, Muriel, María Emilia, Duran, María Eugenia, Zarate Casas, María Fernanda, Florou, Maria, Piacentini, Maria Gaia, Seixo, Maria Inês, Bellini, Maria Irene, Peña Soria, Maria Jesús, Martínez, María José, Medina, Maria José, Rueda Medécigo, María José, Karakeke, Maria, Kausar, Maria, Kyriazi, Maria, Marqueta De Salas, Maria, Modolo, Maria Marta, Mateu, Maria, Mavri, Maria, El Ghoul Miliotou, Maria Melina, Moreno Gijon, Maria, Papadoliopoulou, Maria, Proclamà, Maria Pia, Picciochi, Maria, Reis, Maria, Rennis, Maria, D'Anna, Maria Rosa, Ruffoli, Maria, Ruiz Soriano, María, Sánchez Ramirez, Maria, Sánchez-Rubio, María, Schüler, Maria, Sotiropoulou, Maria, Barrio Renteria, Maria Teresa, Tsopozidi, Maria, Vasconcelos, Maria, Facchino, Maria Vittoria, Wikar, Maria, Aguilera-Arevalo, Maria-Lorena, Abdu, Mariam, Asarbakhsh, Mariam, Elmiesiry, Mariam, Ashong, Marian Esi, Gomes, Mariana, Capuano, Marianna, Lill, Marianne, Nieto Galvan, Mariano, Osso, Mariasara, Olivos, Maricarmen, Sacdalan, Marie Dione, Weber, Marie-Christin, Gonzalez, Marijose De Cristo, Ferreira, Marília, Infantes Ormad, Marina, Kouliou, Marina Nektaria, Ransome, Marina, Vicario Bravo, Marina, Cuesta Argos, Mario, Faletar, Mario, Giuffrida, Mario, Lainez Escribano, Mario, Pacilli, Mario, Pannullo, Mario, Rodriguez-Lopez, Mario, Trejo-Avila, Mario, Merrakos, Marios, Tello Jimenez, Marisol, Kalisvaart, Marit, Quaunine, Marium, Perera, Mariyan, Harris, Mark, Youssef, Mark Melad Thabet, Peter, Mark, Philipp, Mark, Portelli, Mark, Jesudason, Mark Ranjan, Sammut, Mark, Tomlinson, Mark, Zammit Vincenti, Mark, Despotidis, Markos, Albertsmeier, Markus, Quante, Markus, Löffler, Markus W., Gurung, Markush, Gumsheimer, Marlena, Benamrouche, Maroua, Chaccour, Maroun, Ahmed, Marriam, Farooqui, Marryam Riaz, Angelini, Marta, Ortega Escudero, Marta, Martin Gimenez, Marta Pilar, Reia, Marta, Scricciolo, Marta, Caramantin Obando, Martha Maria, Gosselink, Martijn, Bertrand, Martin, Dum, Martin, Kajic, Martin, Karamanliev, Martin, Kyereh, Martin, Lucchini, Martin, Schön, Martin, Morna, Martin Tangnaa, Binda, Martina, Ceolin, Martina, Martorana, Martina, Zambon, Martina, Shams, Marvi, Alansary, Marwa, Alnuwayli, Marwa, Khalifa, Marwa, Bahnacy, Marwan, Iqreewi, Marway, Nnabagulanyi, Mary, Saleem, Marya, Alhimyar, Maryam, Kamal, Maryam, Masood, Maryam, Razaq, Maryam, Siddique, Maryam, Lazo Ramírez, Maryzela, Edeeb, Masaoud, Solkar, Maseera, Adetoyi, Mashood, Adeniyi, Caccetta, Massimiliano, Casati, Massimiliano, Veroux, Massimiliano, Dugo, Massimo, Bevanda, Mateo, Santillan, Mateo, Mietła, Mateusz, Pryt, Mateusz, Muir, Mathew, Bei, Matilda, McGuinness, Matt, Aulicino, Matteo, Castrovillari, Matteo, Filardo, Matteo, Palmeri, Matteo, Pisano, Matteo, Rottoli, Matteo, Gjoka, Mattheus, Binks, Matthew, Corcos, Matthew, Kwon, Matthew, Maybury, Matthew, Sammut, Matthew, Tutton, Matthew, Watson, Matthew, Biebl, Matthias, Janda, Matthias, Maak, Matthias, Wichmann, Matthias, Berselli, Mattia, Gritti, Mattia, Molteni, Mattia, Pacilli, Maurizio, Favoriti, Mauro, Garino, Mauro, Podda, Mauro, Santarelli, Mauro, Alfaid, Mawada, Albert, Mawadri Jimmy Isaac, Oyortey, Mawuenyo Attawa, Enßlin, Max, Berlet, Maximilian, Brunner, Maximilian, Kießler, Maximilian, Scheiterle, Maximilian, Sohn, Maximilian, Busch, Maximiliane, Perkins, Maya, Sabboh, Maya, Badkur, Mayank, Okudero, Mayowa, Mohamedshafee, Maysoon, Al-Juaifari, Maytham Aqeel, Elesseily, Mazen, Mohammad, Mazen, Nikberg, Maziar, Jean Claude, Mbonicura, Şermet, Medeni, Chisthi, Meer, Luthra, Meera, Sulciner, Megan, Kaple, Meghali, Bhat, Meghana, Koç, Mehmet Ali, Avci, Mehmet Alperen, Kizilkaya, Mehmet Celal, Kara, Mehmet Emin, Ozcelik, Mehmet Faik, Ozsoy, Mehmet Sait, Zaigham, Mehreen, Mesfin, Mekdelawit, Kalender, Mekselina, Mellado Tellez, Mel Paul, González De Miguel, Melania, Farrugia, Melanie, Theodoridou, Melanie, Barcelona, Melden Darrell, Aktas, Melik Kagan, Fernández Zurita, Melissa Andrea, Bautista, Melissa, Park, Melissa, Rodríguez-Ordoñez, Melissa-Zohemia, Yashar, Meltem, Worku, Mengistu, Al-Fraijat, Meran, Estaire Gómez, Mercedes, Shoshkova, Meri Danailova, Kruščica, Merima, Tanal, Mert, Çuhadar, Merve, Tokocin, Merve, Agyapong, Meshach Manu, Erkaya, Metincan, Okechukwu, Mgbako, Adinku, Michael, Bickford, Michael, Ediale, Michael, Issa, Michael, Konstantinidis, Michael K., Lie, Michael, M. Nathan, Michael, Maclean, Michael, Nortey, Michael, Pellen, Michael, Pham, Michael, Pitiakoudis, Michael, Singh, Michael Prodip, Spartalis, Michael, Van Der Colf, Michael, Wilson, Michael, Billis, Michail, Karanikas, Michail, Papamichail, Michail, Vailas, Michail, Kisielewski, Michał, Kusiński, Michał, Nycz, Michał, Święch, Michał, Fagbayimu, Micheal, Adamina, Michel, Fiogbe, Michel, Prudhomme, Michel, Angelucci, Michela, Campanelli, Michela, Cricrì, Michele, Grande, Michele, Manigrasso, Michele, Scopelliti, Michele, George, Michelle, Mozel, Michelle, Galasyuk, Mick, Chevallay, Mickael, Giuliano, Micol, Dobón Rascón, Miguel Ángel, Fernandez Romero, Miguel Angel, García Ureña, Miguel Ángel, Zaragoza Mendieta, Miguel Ángel, Bejarano Serrano, Miguel, Brito, Miguel, Calderon, Miguel, Jurado Román, Miguel, Palas, Miguel, Li Valencia, Miguel Roberto, Sebastián-Mendoza, Miguel-Julián, Muresan, Mihai-Stefan, Slavchev, Mihail, Agapov, Mikhail, Milentijević, Milica, Catterall, Millie, Stjepanovic, Milos, Doss, Mina, Natey, Mina, Aikins, Minas, Mattis, Minca, Ekanayake, Minoli Tharushika, Tora, Mir Mehrab Sharmin, Alsharayri, Mira, Shalaby, Mira, Boras, Miran, Riba Martínez, Mireia, Mogiatti, Mirella, Salibašić, Mirhan, Biancu, Miriam, Cappiello, Miriam, Koschke, Miriam Luise, Sadek, Mirna, Szura, Miroslaw, Horga, Miruna, Dason, Mishael, Tayyab, Mishal, Imirski, Mitko, Pejović, Mladen, Tabaza, Mo'Ath, Alneasan, Moaaz, Shalkamy, Moamen, Issa, Moammad Issa, Erfan, Moatasem, Ewedah, Moataz, Srour, Moayad, Beletachew, Moges, Abbas, Mohamad, Farho, Mohamad Ali, Marawy, Mohamad Kher, Klib, Mohamad, Morjan, Mohamad, Sawas, Mohamad Nabhan, Elghriani, Mohamed Abdelbaset Masoud, Abdelmaboud, Mohamed, Abdelmaksoud, Mohamed, Abdullahi, Mohamed, Abo Abdo, Mohamed, Ahmed, Mohamed, Ahmoud, Mohamed, Al Sayed, Mohamed, Suliman, Mohamed Almouafaq, Alsori, Mohamed, Altajouri, Mohamed, Assalhi, Mohamed, Berrakkouch, Mohamed, Elnour, Mohamed, Abdelsalam, Mohamed Elsayed Elaraby 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Abosedra, Mohammed, Sarker, Mohammed Abu Kawsar, Abudabbous, Mohammed, Abuwarda, Mohammed, Elgak, Mohammed Ahmed, Al Hinai, Mohammed, Al Zebda, Mohammed, Al-Shehari, Mohammed, Alharthi, Mohammed, Ali, Mohammed, Ismael Alamin, Mohammed Ali, Alqadasi, Mohammed, Alshanwani, Mohammed, Alshehri, Mohammed, Asaad, Mohammed, Bashir, Mohammed, Bohlala, Mohammed, Meghaizerou, Mohammed El Amine, Albanna, Mohammed Emad Hashem, Ghunaim, Mohammed, Goga, Mohammed, Hajhamad, Mohammed, Hamada Takrouney, Mohammed, Hammoda, Mohammed, Hamoud Almahly, Mohammed, Muragi, Mohammed, Mohammed, Mohammed Mustafa Hassan, Obaid, Mohammed, Omar, Mohammed, Said, Mohammed, Salah, Mohammed, Saleh Khatab, Mohammed, Aliyu, Mohammed Salele, Shakhshir, Mohammed, Sheriff, Mohammed, Tageldin, Mohammed, Abdelfattah, Mohanad, Daher, Mohanad, Lotfy, Mohanad, Alqedrh, Mohannad, Nasani, Mohannad, Mohd Shah, Mohd Shahrulsalam, Madany, Mohie El-Din Mostafa, Mobolaji-Ojibara, Mojisola, Nkogatse, Moleseng, Alazabi, Mona, Gupta, Money, Bogdan, Monica, Guerrero, Monica, Noguez Castillo, Monica, Gureh, Monika, Kacem, Montasser Jamaleddine, Tarar, Moosa Feroze, Seto, Morel, Steinruecke, Moritz, Edena, Morrison, Abdulsalam, Moruf, Abdelhadi Suliman Adam, Mosab, Saleh, Mosab, Anati, Mosaikah, Dokurugu, Moses Abdulai, Agunloye, Moses, Ibadin, Moses, Momoh, Moses, Abdelkarim, Mostafa, Kamar, Mostafa, Kotb, Mostafa, Mahran, Mostafa, Mohamad Amin, Mostafa, Shalaby, Mostafa, Waseem, Mostafa, Almaletti, Motasem, Saifi, Motaz, Tsuruta, Motohisa, Agbadebo, Mouhamed, Arnaout, Moumen, Ojo, Moyosoluwa, Sharma, Mrthyunjayani, Azzuz, Muad Mohamed Ramadan, Haj Hussein, Mudar, Ameen, Muftiat Omolola, Nkoronko, Mugisha, Fitri, Muhamad, Abdullah, Muhammad, Bashir, Muhammad Ahmad, Sadiq, Muhammad Ahmad, Ahmed, Muhammad, Ali, Muhammad, Al-Yusuf, Muhammad Ali, Haider, Muhammad Aliyan, Alshaar, Muhammad, Mirza, Muhammad Bilal, Che Yaacob, Muhammad, Daniyan, Muhammad, Elzayat, Muhammad, Butt, Muhammad Faizan, Sadiq, Muhammad Hamza, Chishti, Muhammad Haris, Ismail, Muhammad Izzat Shufphi, Kashif, Muhammad, Khalid, Muhammad, Mansoor Iqbal, Muhammad, Bin Khalid, Muhammad Moaz, Rafique, Muhammad Nouman, Raheem, Muhammad, Khalid, Muhammad Saud, Usama, Muhammad, Usman Malik, Muhammad, Saqib, Muhammad Waleed, Elhadi, Muhammed, Ateş, Muhammed Ikbal, Demirpolat, Muhammed Taha, Ergenç, Muhammer, Bello, Muideen, Kulimbet, Mukhtar, Nyirenda, Mulinda, Taeme, Mulugeta, Denini, Muna, Aziz, Munazzah, Yahaya, Mundashiru, Eugene, Muneza, Amadu, Munira, Chauhan, Munish, Acar, Murat, Teressa, Murti, Dauphin, Muryango, Arafat, Musa, Althomali, Musab, Rayzah, Musaed, Husain, Musharraf, Tolani, Musliu Adetola, Abu Jayyab, Mustafa, Al-Attraqchi, Mustafa, Kara, Mustafa Alper, Seker, Mustafa Ege, Gün, Mustafa, Hamed, Mustafa, Mehanny, Mustafa, Oncel, Mustafa, Sabri Massadi, Mustafa, Uyanik, Mustafa Safa, Uzunoglu, Mustafa Yener, Abdullahi, Mustapha, Saidani, Mustapha, Nofal, Mutaz, San, Myat, Ishak, Myrna, Keramida, Myrto D., Nik Burhanuddin, N.M. Syahrin, Talat, Nabila, Shehata, Nada, Alasbahi, Nadeen, Marcos, Nádia, Al Amri, Nadiah, Absy, Nadine, Parker, Naeelah, Lindi, Naeimah, Omer, Nafisa, Papadogianni, Nafsika, Rawal, Nagendra, Ismaiel, Nahar, Ben Hasan, Najat, Albahloul, Najla, Gokhare Viswanath, Nakul, Srinivas, Namitha, Christian, Nana Ama, Obuobi, Nana Kwame Asare, Beharry, Naomi, Yousefzadeh Kandevani, Naser, Alnamari, Nashwan, Oyelowo, Nasir, Oloko, Nasirudeen, Alzerwi, Nasser, Mosbah, Nasser, Shulman, Nastassia, Andrade, Natacha, Boumas, Natacha, Cobeño Tamayo, Natalia, Barrera Lopez, Natalia Guadalupe, Palamara, Natalia, Blencowe, Natalie, Marzouqa, Natalie, Blencowe, Natalie S, Salgadoe, Natalie, Techapongsatorn, Nathakorn, Paez, Nathaly, Ekwo, Nathan, Saini, Navdeep, Malik, Naveed Akhtar, Sharma, Naveen, Kumar, Navin, Chaudhry, Navneet Kumar, Karimbocus, Nawaaz, Rasool, Nazeerah, Lodhi, Nazia, Kavak, Nazli, Ildephonse, Ndayiragije, Diomede, Nduwimana, Bayleyegn, Nebiyou S., S.Bayleyegn, Nebiyou, Jović, Nediljko, Mosleh, Neebal, Aruldas, Neerav, Kapur, Neeti, Paul Sigamony, Negine Paul, Karthikeyan, Neha, Tabatabaian, Nelia, Affram, Nelson, Agboadoh, Nelson, Tran, Nelson, Lalovic, Nenad, Agugua-Obianyo, Nene, Kullab, Nermen, Lahmer, Nesrin, Raiq, Neven, Soldo, Neven, Spiteri, Neville, Chen, Nevin, Al Rabadi, Nezar, Christian, Ngarambe, Cabrel, Ngongang Ngansop, Leonelle Lore, Nguefack Noudem, Furbetta, Niccolò, Ensor, Nicholas, Tsantikos, Nick, Seeger, Nico, Cillara, Nicola, Eardley, Nicola, Petrarota, Nicola, Tartaglia, Nicola, Feijoo, Nicolas, Finocchiaro, Nicole, Koter, Nicole, De Santis, Nicolò, Fabbri, Nicolò, Schiavon, Nicolò, Tamini, Nicolò, Sharma, Nidhi, Sánchez Fuentes, Nieves, Solomon, Nigus, Bugdayci, Nihat, Lekiashvili, Nika, Gupta, Nikhil, Narain, Nikhil, Uttam, Nikita, Kłos, Nikola, Ververidis, Nikolaos Adrianos, Arkadopoulos, Nikolaos, Dimitrokallis, Nikolaos, Garmpis, Nikolaos, Gouvas, Nikolaos, Kalampokis, Nikolaos, Kopanakis, Nikolaos, Kydonakis, Nikolaos, Machairas, Nikolaos, Memos, Nikolaos, Michalopoulos, Nikolaos, Mathioudakis, Nikolaos Nestor, Roukounakis, Nikolaos, Stamos, Nikolaos, Tasis, Nikolaos, Tsakiridis, Nikolaos, Vlachakos, Nikolaos, Zampitis, Nikolaos, Kouzakos, Nikolas, Börner, Nikolaus, Dimitriou, Nikoletta, Dafnios, Nikos, Banerjee, Niladri, Klammer, Nils, Maharjan, Nima, Rabai, Nimah, Oscar, Nimpaye, Harrison, Nina, Kheyrbek, Nina, Kansakar, Nirajan, Bhat, Nisar, Krishnappa, Nischal, Pahuja, Nisha, Paul Ambrose, Nitin, Renovat, Niyongabo, Musawa, Nizar, Nwanne, Njideka, Steve, Nkurunziza, Chidumije, Nnaemeka, Nwafulume, Nnaemeka, Celestine, Nnamani, Duru, Nnamdi, López Bernal, Noelia Esthela, Laquatra, Noemi, Pasqua, Noemi, Awwad, Noor Al-Deen, Ali, Nora, Hielscher, Nora, Trabulsi, Nora, Hüser, Norbert, Muñoz Montes, Norberto, Eshak, Norma-Sol, Rajab, Nosaiba, Lahnaoui, Nouhaila, Ouachou, Nouhaila, Ali, Nour, Dadoush, Nour, Fazili, Noureen, Theophile, Ntahompagaze, Ntanzi, Ntuthuko, Bibila, Nubia Samuel, Alwaer, Nuhay, Naabo, Nuhu, Jiagge, Nuna, Freitas Oliveira, Nuno Miguel, Pratas, Nuno, Morricone, Nunzia, Franco, Nunzio Francesco, Binti Yusri, Nur Aima, Ramli, Nur Natasya, Abd Ghani, Nur Suriyana, Umar, Nura, Aly, Nuran Khaled, Lakhanov, Nurgali, Al-Hroub, Nurhan, Kiziltoprak, Nurhilal, Chavarrias, Nuria, Maulenov, Nurlan, Akinbami, Nurudeen, Abdulraheem, Nurudeen Toyin, Karunaratne, Nuwanthika, Jeannette, Nyiransabiyera, Altobaishat, Obieda, Egwuonwu, Ochonma Amobi, Enciu, Octavian, Cohen-Arazi, Oded, Pheiffer, Odette, Okoye, Odili Aloysius, Omoike, Ofure, čančar, Ognjen, Ekwunife, Okechukwu Hyginus, Emuze, Okundayo, Eljizoly, Ola Abdallah, Al Hamdani, Ola, Emadeldeen, Ola, Morgan, Ola, Olajumoke, Oladapo, Popoola, Olakunle, Ajiboye, Olalekan, Olasehinde, Olalekan, Jolayemi, Olamide, Babatunde, Olanrewaju, Balogun, Olanrewaju, Olajide, Olawumi, Lisin, Oleg, Bellou, Olga, Jurić, Oliver, Ladlow, Oliver, Whitehurst, Oliver, Camilleri, Olivia, Montaño Angeles, Olivia, Pryer, Olivia, Ray, Olivia, Gabom, Olivier, Ndizeye, Olivier, Ojewuyi, Olufemi, Oluyemi, Olukayode, Elebute, Olumide, Ogunsua, Oluseyi, Fasiku, Olushola Kayode, Fasoro, Olusola, Fatudimu, Oluwafemi, Osunlusi, Oluwafemi, Owolanke, Oluwagbenga, Oso, Oluwarotimi, Alaba, Oluwaseun, Ojo, Oluwaseun, Oluseye, Oluwaseun, Oyinloye, Oluwaseun, Al Alyani, Omaima, Okrah, Omane, Agha, Omar, Al-Fahel, Omar, Almomani, Omar, Alruwaili, Omar, Ibarra, Omar, Ibrahim, Omar, Khalil, Omar, Kouli, Omar, Lima Azurdia, Omar, Mansour, Omar, Mohamed Mokbel, Omar, Omar, Omar, Bedak, Omer, Ozkan, Omer Faruk, Yalkın, Omer, Mohamed, Omnia, Ayandipo, Omobolaji, Faboya, Omolara, Williams, Omolara Modupe, Irowa, Omorodion, Attawodi, Onuche, Salako, Opeyemi, Ioannidis, Orestis, Agcaoglu, Orhan, Martin Sole, Oriol, Webster, Orla, Abouhiekal, Osama, Al Shaqran, Osama, Bahsas-Zaky, Osama, Nubi, Osama Gamal, Hany, Osama, Matar, Osama, Mahafdah, Osama R., Sarhan, Osama, Osagie, Osasumwen, Soublett Rivas, Óscar Alexander, Gülcicek, Osman Bilgin, Cuenca Torres, 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Udwan, Suad, Raul, Subrat, Chase, Suchita, Nair, Sudharrshan, Joseph, Sudhir, Singh, Sudhir Kumar, Singh, Sudhir, Timmalah, Suhaylah, Alsuwiyah, Suhir, Thalgaspitiya, Sujeewa Priyantha Bandara, Sellahewa, Sujeewa, Neogi, Sujoy, Burger, Sule, Polat, Süleyman, Alkadi, Sulman, Asiri, Sultan, Otho, Sumaira, Mewa Kinoo, Suman, Ebrahim, Sumayyah, Tontus, Sumeyya, Midya, Sumit, Thuraisamy Sarma, Sundaramoorthy Iyer, Payyanur Thotan, Sundeep, Kumar Venkatappa, Sunil, Techapongsatorn, Suphakarn, Kaur, Supreet, Jp, Supritha, Tan, Suqi, Djote, Surafel Mulatu, Surendran, Suraj, Singh, Surendra, Chilaka, Suresh, Lee, Susan, Henriques, Susana, Giridaran, Suseendirarajah, Achugatla, Sushma, Kumar, Suvam, Brincat, Svetlana, Deshpande, Swati, Batista, Sylvia, Akharaekpanya, Tachporn, Moges, Tadesse Girma, Türkmen, Taha Berkay, Alhaj Hasan, Taima, Alshawabkeh, Taima', Majed, Taima', Lawal, Taiwo Akeem, Ibiyeye, Taiye Taibat, Rashid, Tajamul, Košir Božič, Tajda, Mohammed, Tajudeen, Khewater, Talal, Abelman, Talia, Al Barhi, Tamadher, Mogne, Tamiris, Salazar-Lorenzana, Tania Abril, Akter, Tania, Gómez Sanz, Tania, Motiwala, Tanmay, Valizadeh Elizeh, Tanya, Almahdi, Tanzeel, Albushary, Tanzel Alrahman, Abdulrahman, Taofeeq, Finlay, Tara, Chouari, Tarak, Awad, Tarek, Sabra, Tarek, M. Abubasheer, Tareq, Alhusban, Tariq, Yılmaz, Tarık Emre, Aloqaili, Tasneem, Aldirawi, Tayef, Karahasanoğlu, Tayfun, Gülşen, Taygun, Jemal, Tebarek, Nadeem, Tehmina, Singh, Tejinder Paul, Alinger, Temsula, Longkumer, Temsutoshi, Lo, Terence, Gimenez Maurel, Teresa, Uprak, Tevfik Kıvılcım, Petropoulou, Thalia, Rawther, Thampi, Techapongsatorn, Thawin, Manickam, Thendral, Padioti, Theodora, Kozonis, Theodoros, Sidiropoulos, Theodoros, Tsirlis, Theodoros, Theodosopoulos, Theodosios, Hessou, Thierry Kinnongni, Uiyapat, Thitapon, Agyen, Thomas, Harris, Thomas, Hugh, Thomas J, Jorgensen, Thomas W., Theivendrampillai, Thrshegan, Pham, Thuy Vy, Branco, Tiago, Nagwamutse, Tijjani Nasiru, Tony V, Tina, Devabalan Koil, Titus, Pilia, Tiziana, Abdulmola, Tmador Mahmed Ali, Oyeyemi, Tobiloba, Kebede, Tolera, Ibarra-Hurtado, Tomás Ramón, Reichelt, Tomas, Gach, Tomasz, Stefura, Tomasz, Wojewoda, Tomasz, Soric, Tomislav, Risteski, Toni, Tridip, Tridip Dutta Baruah, Yotsov, Tsanko, Doma Bhutia, Tshering, Girma, Tsion, Kwan, Tsun Yu, Ivanov, Tsvetomir, Iahmo, TT, Ashkar, Tuleen, Mabogoane, Tumi, Olobatoke, Tunde, Sholadoye, Tunde T., Mishra, Tushar Subhadarshan, Parker, Tyla, Ezomike, Uchechukwu, Dilibe, Uchenna, Kumbhar, Uday, Una, Uduak-Abasi, Grossi, Ugo, Ezidiegwu, Ugochukwu, Edith, Ugwuoke, Daspal, Ujjwal, Kalu, Ukoha Agwu, Dietz, Ulrich, Ronellenfitsch, Ulrich, Wirth, Ulrich, Abdullah, Umar, Rivolta, Umberto, Jayarajah, Umesh, Kanyan Kassim, Umu-Hera, Govindan, Unnikrishnan, Fernandes, Urânia, Akram, Usman, Mohammed Bello, Usman, Omara, Usra, Naidoo, Uvarasen, Mahendravarman, Vaishnaivy, Negoita, Valentina Madalina, Mariottini, Valentina, Murzi, Valentina, Zucchini, Valentina, Agbakwuru, Valentine, Armenta Tapia, Valeria Estefania, Gentilino, Valerio, Borgogni, Vanessa, Ng, Vanessa, Wolfschluckner, Vanessa, Silvestri, Vania, Žufić, Vanja, Gunasaegaram, Varman, Kamalathevan, Vasan, Pillay, Vasanthan, Neykov, Vasil, Kalles, Vasileios, Mousafeiris, Vasileios, Papadopoulos, Vasileios, Tsaousis, Vasileios, Tselepidis, Vasileios, Vougas, Vasileios, Georgilaki, Vasiliki, Nikolaou, Vasiliki, Themelidi, Vasiliki, Manchev, Vassil, Ioannou, Veatriki, Jha, Vedant Shekhar, Dragisic, Vedran, Sutharshan, Vengadasalam, Alonso, Veronica, Brocco, Veronica, Ongil Rodríguez, Verónica, Schirinzi, Veronica, Budyakova, Veronika, Naunova, Vesna, Panduro-Correa, Vicky, Ruiz López, Víctor Andrés, Bill, Victor, Dassah, Victor, Gonzabay, Víctor Eduardo, Etwire, Victor, Modekwe, Victor, Serna-Alarcon, Victor, De Donato, Victor Ugo, Duque Mallén, Victoria, Liu, Victoria, Sharma, Vidushi, Kumar, Vijaya, Muralidharan, Vijayaragavan, Kakotkin, Viktor, Enemuo, Vincent, Kudoh, Vincent, Osoka, Vincent, Siepaal, Vincent, Granata, Vincenza, Dinuzzi, Vincenza Paola, Lizzi, Vincenzo, Ricchiuti, Vincenzo, Mosca, Vinicio, Kanna D, Vinoth, Nair, Vipin Venugopal, Ledda, Virginia, Michael, Vishal, Singh, Vishavdeep, Govindasamy, Vishendran, Kollengode, Viswanathan V, Giordano, Vittoria, Morinelli, Vittoria, Lin, Vivian, Cuk, Vladica, Cijan, Vladimir, Çalik, Volkan, Bakshi, Vrushank, Ten, Vyacheslav, Ratheesh, Vysakh, Alsado, Wael, Mayo, Wafik, Yang, Wah, Rehman, Wajeeh Ur, Abbas, Walaa, Al-Khyatt, Waleed, Mabood, Waleed, Santucci, Walter, Yew, Wan Ting, Tahir, Warda, De Silva, Warusha Dhammika Dulantha, Wijenayake, Wasantha, Almadhoun, Waseem J.N., Alhroub, Wasef, Ebrahim, Wesam, Jabłoński, Wiktor, Krawczyk, Wiktor, Bhatti, William, Lai, William Kwan Ho, Petrushnko, Wilson, Afedo, Wisdom, Kasetsermwiriya, Wisit, Serednicki, Wojciech, Wysocki, Wojciech, Zerefa, Wondwossen Amtataw, Vagena, Xanthoula, Tarrado, Xavier, Papazarkadas, Xenofon, Po, Xiang Yuen, Ouadi, Yacine, Myla, Yacob, Haido, Yacoub, Hasan, Yafea, Karataş, Yağmur, Carpio Colmenares, Yahaira, Galvañ Félix, Yaiza, Balogun, Yakub Lekan, Maktabi, Yaman, Nerabani, Yaman, Fulgence, Yamuremye, De Silva, Yannick, Asar, Yara, Samer Morsy, Yara, Ghaleb, Yasameen Saif Saeed Mohammed, Vashishth, Yash, M S, Yashas, Manickchund, Yashoda, Sakaray, Yashwant, Kara, Yasin, Tosun, Yasin, Zwain, Yasir, Farag, Yasmeen, Jedidi, Yasmine, Seada, Yasmine, Aldebasi, Yasser, Ashour, Yasser, Badr, Yassin, Sarpong, Yaw, Alawneh, Yazan, Aung, Yee Lay, Orabi, Yehia, Lam, Yick Ho, Şen, Yigit Kaan, Koyluoglu, Yilmaz Onat, Huang, Yining, Mintz, Yoav, Perez, Yocarli, Chamara, Yohan, Melkamu, Yohannes, Maestre González, Yolanda, Dean, Yomna, Metaferia, Yonas Yilma, Malki, Yosra, Mohamed, Younis, A. Omar, Yousef, Alhammoud, Yousef, Allaoua, Yousef, Tanas, Yousef, El Okazy, Youssef, Kerolous, Youssef, Mohamed, Youssef, Al-Junaidi, Youssuf, Lakdawala, Yousuf, Lu, Yuann, Asano, Yukio, Altinel, Yuksel, Aktimur, Yunus Emre, Fishman, Yuri, Kudryavcev, Yurii, Tandoğan, Yusuf Iskender, Razafimandimby, Yves Michaël, Adofo-Asamoah, Yvonne, Şenol, Zafer, Odeh, Zahra, Benamrouche, Zahra Rayane, Alkhaier, Zahraa, Al-Sheikh Ali, Zaid, Zaher, Zain Aldin, Alnajjar, Zaina, Al-Balushi, Zainab, Alkhuzaie, Zainab, Khraim, Zakaria, Toutounji, Zakaria, Djama, Zakarya, Farraj, Zamil, Shah, Zamir Ahmad, Khan, Zara, Khan, Zarnigar, Abo Alarous, Zayn Alabden, Asaad, Zaynab, Demetrashvili, Zaza, Lorenc, Zbigniew, Brekalo, Zdrinko, Hannouneh, Zein Alabdin, Robertson, Zelda, Bady, Zeyad, Durna, Zeynep, Wong, Zhen Yu, Fozo, Zien Alabdin, Klib, Zienab, Chin, Ziling, Tamou, Zime Farid, Johnson, Zina, Shabello, Ziyad, Orzeszko, Zofia, Aljalabi, Zohal, Al-Azher El-Hamel, Zohour, Karampotaki, Zoi Rafaila, Valera Sanchez, Zoraida, Matkovic, Zoran, Azhar, Zubair, Qureshi, Zubaria, Correa López, Zulema Margarita, Balciscueta, Zutoia, Musilová, Zuzana, Katusic, Zvonimir, Osama, Zyad, and Dauksa, Zygimantas
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- 2024
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7. Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence
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Müller, Philip C., Pfister, Matthias, Eshmuminov, Dilmurodjon, and Lehmann, Kuno
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- 2024
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8. Self-expandable metallic stent as bridge to surgery vs. emergency resection in obstructive right-sided colon cancer: a systematic review and meta-analysis
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Mäder, Mirjam, Kalt, Fabian, Schneider, Marcel, Kron, Philipp, Ramser, Michaela, Lopez-Lopez, Victor, Biondo, Sebastiano, Faucheron, Jean-Luc, Yoshiyuki, Suzuki, von der Groeben, Markus, Novak, Allan, Teufelberger, Gerfried, Lehmann, Kuno, and Eshmuminov, Dilmurodjon
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- 2023
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9. Serum procalcitonin improves diagnosis of infectious complications after CRS/HIPEC
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Roth, Lilian, Eshmuminov, Dilmurodjon, Russo, Linda, Laminger, Felix, Kober, Friedrich, Roka, Sebastian, and Lehmann, Kuno
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- 2023
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10. What have we learnt from the past – would treatment decisions for GEP-NET patients differ between 2012 to 2016 by the new recommendations in 2022?
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Stiefel, Rahel, Lehmann, Kuno, Winder, Thomas, and Siebenhüner, Alexander R.
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- 2023
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11. FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review
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Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno
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- 2023
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12. What have we learnt from the past – would treatment decisions for GEP-NET patients differ between 2012 to 2016 by the new recommendations in 2022?
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Rahel Stiefel, Kuno Lehmann, Thomas Winder, and Alexander R. Siebenhüner
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GEP-NET ,Treatment sequences ,SSA ,Overall survival ,Progression free survival ,Real-life population ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors with a broad range of local and systemic treatment options. Still a lack of data regarding treatment sequences exists. The aim of this study was to analyse outcomes in GEP-NETs depending on stage and treatment steps and compare our treatment decisions to the latest treatment recommendations of European Society of Medical Oncology (ESMO) 2020 for GEP-NETs. Methods Patients were included in this retrospective single-center analysis from 2012—2016. All patients suffering from a GEP-NET, who were screened, treated or evaluated at ENETS Center in Zurich, Switzerland were included in analysis. Patients with any other diagnosis of NET were not included. We used Kaplan Meier estimator as well as Cox regression to compare survival rates between different sites of localization, grades or stages and treatment sequences. Results Overall, we identified 256 GEP-NETs, most in advanced stage (62%) and located in small intestine tract or pancreatic gland. Survival depended on stage, grade, primary site and duration of response for the early systemic treatment. On average patients underwent 2.6 different treatment modalities, mostly depending on stage and higher tumor grade. Surgery was performed early but also in advanced stages, usually followed by Somatostatine-Agonist modalities. In distant disease (Stage IV), we investigated a positive effect of PFS after treatment with Somatostatine Analogues (SSA) (hazard ratio [HR], 0.45; 95% confidence interval [CI], 0.21 – 0.97; p = 0.04) and systemic treatment (HR, 0.51; 95% CI, 0.26 – 0.99; p = 0.047) if patients underwent prior surgery or endoscopic resection. Kaplan Meier distributions predict shorter OS in distant disease (Stage IV), (Figure. 1; HR, 2.06; 95% CI, 1.46 – 2.89; log-rank test, p
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- 2023
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13. Transplantation for metastatic liver disease
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Clift, Ashley Kieran, Hagness, Morten, Lehmann, Kuno, Rosen, Charles B., Adam, Rene, Mazzaferro, Vincenzo, and Frilling, Andrea
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- 2023
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14. Serum procalcitonin improves diagnosis of infectious complications after CRS/HIPEC
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Lilian Roth, Dilmurodjon Eshmuminov, Linda Russo, Felix Laminger, Friedrich Kober, Sebastian Roka, and Kuno Lehmann
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Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve the survival of selected patients with peritoneal metastasis. A major cause of treatment-related morbidity after CRS/HIPEC is infection and sepsis. HIPEC alters the diagnostic sensitivity and specificity of blood and serum markers and therefore has an impact on early diagnosis of postoperative complications. This study aimed to assess the sensitivity and specificity of blood and serum markers after CRS/HIPEC. Methods Patients from two centers, operated between 2009 and 2017, were enrolled in this study. Perioperative blood samples were analyzed for white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT); postoperative complications were graded according to Clavien-Dindo and infectious complications according to CDC criteria. Results Overall, n=248 patients were included with peritoneal metastasis from different primary tumors treated by CRS/HIPEC. Depending on the applied HIPEC protocol, patients presented a suppressed WBC response to infection. In addition, a secondary and unspecific CRP elevation in absence of an underlining infection, and pronounced after prolonged perfusion for more than 60 min. PCT was identified as a highly specific — although less sensitive — marker to diagnose infectious complications after CRS/HIPEC. Discussion/conclusion Sensitivity and specificity of WBC counts and CRP values to diagnose postoperative infection are limited in the context of HIPEC. PCT is helpful to specify suspected infection. Overall, diagnosis of postoperative complications remains a clinical diagnosis, requiring surgical expertise and experience.
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- 2023
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15. Management of abdominal pseudotumours in haemophilia: a systematic review
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Franz von Stauffenberg, Inga Hegemann, Rahel Schwotzer, Kuno Lehmann, and Jeannette Widmer
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Medicine - Abstract
AIM: Haemophilic pseudotumours are complications in patients with haemophilia A or B and result from locally repetitive bleeding, mainly in the musculoskeletal system. Abdominal haemophilic pseudotumours are exceptionally rare but may cause severe complications. This systematic review aimed to evaluate therapy strategies for symptomatic abdominal haemophilic pseudotumours. METHODS: We systematically searched three databases (Medline [PubMed], Web of Science and EMBASE) for publications published between 1995 and 2023. Two reviewers independently selected the studies, extracted data and performed a quality assessment using the JBI critical appraisal checklist. RESULTS: From a total of 1199 articles, 39 articles describing 41 cases were included for final analysis. Conservative or interventional treatment was performed in 12 cases. In eight cases, a step-up to surgical therapy after interventional treatment was indicated. Primary surgical therapy was performed in 21 cases. Failure to cure was documented in 50% (n = 6) of patients treated in the first group, with a mortality rate of 16.6% (n = 2). Interventional therapy with a step-up to surgery showed no morbidity or mortality. Primary surgical resection documented favourable results in 66.6% (n = 14), with failure to cure in 9.5% (n = 2) and a mortality rate of 14.3% (n = 3). CONCLUSION: Primary surgical resection can be a first-line therapy for symptomatic, abdominal haemophilic pseudotumours, whereas preoperative embolisation could be used as a bridging therapy before surgery, especially in emergency settings. Diagnostic biopsy and percutaneous drainage should be avoided to prevent complications.
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- 2023
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16. ASO Visual Abstract: FOLFIRINOX or Gemcitabine Based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-Institutional, Patient-Level Meta-Analysis and Systematic Review
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Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., Malleo, Giuseppe, Schmocker, Ryan K., Abdallah, Raëf, Yoo, Changhoon, Shaib, Walid L., Schneider, Marcel André, Rangelova, Elena, Choi, Yoo Jin, Kim, Hongbeom, Rose, J. Bart, Patel, Sameer, Wilson, Gregory C., Maloney, Sarah, Timmermann, Lea, Sahora, Klaus, Rössler, Fabian, Lopez-Lopez, Víctor, Boyer, Emanuel, Maggino, Laura, Malinka, Thomas, Park, Jeong Youp, Katz, Matthew H. G., Prakash, Laura, Ahmad, Syed A., Helton, Scott, Jang, Jin-Young, Hoffe, Sarah E., Salvia, Roberto, Taieb, Julien, He, Jin, Clavien, Pierre-Alain, Held, Ulrike, and Lehmann, Kuno
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- 2023
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17. The Burden of ABO-Incompatible Kidney Transplantation: Readmission Rates and Complications, a Twenty-Year Analysis.
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Berchtold, Caroline, Huebel, Kerstin, Roessler, Fabian, Graf, Nicole, Dutkowski, Philipp, Lehmann, Kuno, Mueller, Thomas, and de Rougemont, Olivier
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BLOOD group incompatibility ,CHRONIC kidney failure ,SURGICAL complications ,KIDNEY physiology ,GRAFT survival ,KIDNEY transplantation - Abstract
Background/Objectives: ABO-incompatible live-donor kidney transplantation (ABOi-LDKT) has become an established treatment for end-stage renal disease. Non-inferiority in the long-term graft function compared to ABO-compatible live-donor kidney transplantations (ABOc-LDKTs) has been shown. However, the assumed burden due to complications owing to increased immunosuppression inherent to ABOi-LDKTs has not yet been quantified. The aim of this study was to determine if ABOi-LDKT recipients suffer from additional morbidity and whether the resulting burden is justified. Methods: We retrospectively analyzed 45 matched pairs of ABOi-LDKTs and ABOc-LDKTs transplanted over a twenty-year period from January 2000 to March 2020. The number and duration of postoperative readmissions, surgical complication rates according to Clavien–Dindo and its comprehensive complication index (CCI), kidney function, occurrence of new-onset diabetes, and infections as well as tumor incidence were analyzed. Results: Patient and graft survival, as well as graft function, were comparable between the two groups. There were no significant differences in terms of complications, readmission rates, and length of readmission, as well as infection and rejection rates. The median CCIs for ABOi-LDKTs and ABOc-LDKTs at primary discharge and 3, 6, 12, and >12 months were 20.9 vs. 20.9 (p = 0.363), 31.4 vs. 33.7 (p = 0.438), 33.7 vs. 33.7 (p = 0.875), 20.9 vs. 33.1 (p = 0.25), and 27.1 vs. 31.9 (p = 0.163), respectively. Conclusions: ABOi-LDKT seems safe, with comparable outcome, complication, and readmission rates to ABOc-LDKT. In recipients with ABOi living donors, transplantation should not be delayed solely due to concerns over increased perioperative risks. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal
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Eshmuminov, Dilmurodjon, Studer, Debora J., Lopez Lopez, Victor, Schneider, Marcel A., Lerut, Jan, Lo, Mary, Sher, Linda, Musholt, Thomas J., Lozan, Oana, Bouzakri, Nabila, Sposito, Carlo, Miceli, Rosalba, Barat, Shoma, Morris, David, Oehler, Helga, Schreckenbach, Teresa, Husen, Peri, Rosen, Charles B., Gores, Gregory J., Masui, Toshihiko, Cheung, Tan-To, Kim-Fuchs, Corina, Perren, Aurel, Dutkowski, Philipp, Petrowsky, Henrik, Thiis-Evensen, Espen, Line, Pål-Dag, Grat, Michal, Partelli, Stefano, Falconi, Massimo, Tanno, Lulu, Robles-Campos, Ricardo, Mazzaferro, Vincenzo, Clavien, Pierre-Alain, and Lehmann, Kuno
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- 2023
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19. A systematic review of the perforated duodenal diverticula: lessons learned from the last decade
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Kapp, Joshua R., Müller, Philip C., Gertsch, Philippe, Gubler, Christoph, Clavien, Pierre-Alain, and Lehmann, Kuno
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- 2022
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20. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) vs CRS alone for treatment of endometrial cancer with peritoneal metastases: a multi-institutional study from PSOGI and BIG RENAPE groups
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Gomes David, Manuel, Bakrin, Naoual, Salleron, Julia, Kaminsky, Marie Christine, Bereder, Jean Marc, Tuech, Jean Jacques, Lehmann, Kuno, Mehta, Sanket, Glehen, Olivier, and Marchal, Frédéric
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- 2022
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21. Cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) vs CRS alone for treatment of endometrial cancer with peritoneal metastases: a multi-institutional study from PSOGI and BIG RENAPE groups
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Manuel Gomes David, Naoual Bakrin, Julia Salleron, Marie Christine Kaminsky, Jean Marc Bereder, Jean Jacques Tuech, Kuno Lehmann, Sanket Mehta, Olivier Glehen, and Frédéric Marchal
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HIPEC ,Endometrial cancer ,Carcinomatosis ,Cytoreductive surgery ,Peritoneal metastasis ,Surgery ,RD1-811 - Abstract
Abstract Objective To investigate the benefit of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for the treatment of endometrial peritoneal carcinomatosis compared to CRS alone. Methods We conducted a retrospective multicentre study of patients from experienced centres in treating peritoneal malignancies from 2002 to 2015. Patients who underwent surgery for peritoneal evolution of endometrial cancer (EC) were included. Two groups of 30 women were matched and compared: “CRS + HIPEC” which used HIPEC after CRS, and “CRS only” which did not use HIPEC. We analysed clinical, pathologic and treatment data for patients with peritoneal metastases from EC. The outcome measures were morbidity, overall survival (OS), and progression-free survival (PFS). Results In “CRS plus HIPEC” group, 96.7% of women were treated for recurrence, while in “CRS only” 83.3 were treated for primary disease. There was no significant difference between Peritoneal Carcinomatosis Index at laparotomy or Completeness of Cytoreduction score. Grade III and IV complications rates did not significantly differ between “CRS plus HIPEC” group and “CRS only” group (20.7% vs 20.7%, p = 0.739). Survival analysis showed no statistical difference between both groups. Median OS time was 19.2 months in “CRS plus HIPEC” group and 29.7 months in “CRS only” group (p = 0.606). Median PFS survival time was 10.7 months in “CRS plus HIPEC” group and 13.1 months in “CRS only” group (p = 0.511). Conclusion The use of HIPEC combined to CRS did not have any significance as regard the DFS and OS over CRS alone in patients with primary or recurrent peritoneal metastasis of endometrial cancer.
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- 2022
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22. ASO Author Reflections: Chemotherapy Regimen in Borderline Resectable and Locally Advanced Pancreatic Cancer—Resection Cuts the Deal
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Eshmuminov, Dilmurodjon, Aminjonov, Botirjon, Palm, Russell F., and Lehmann, Kuno
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- 2023
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23. Gastric cancer with positive peritoneal cytology: survival benefit after induction chemotherapy and conversion to negative peritoneal cytology
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Massimiliano Valletti, Dilmurodjon Eshmuminov, Nicola Gnecco, Christian Alexander Gutschow, Paul Magnus Schneider, and Kuno Lehmann
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Gastric cancer ,Peritoneal lavage cytology ,Peritoneal metastasis, Neoadjuvant chemotherapy ,Surgery ,RD1-811 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background The optimal treatment in patients with gastric cancer and peritoneal disease remains controversial. Some guidelines indicate palliative treatment only, while others consider surgical treatment in case of positive lavage cytology (CY+) or limited peritoneal disease. Here, we analyzed the role of peritoneal disease in patients with gastric cancer, and the prognostic relevance of response to neoadjuvant therapy. Methods In this retrospective cohort analysis, we analyzed patients with adenocarcinoma of the stomach or esophago-gastric junction from a single center operated between 2011 and 2019. According to histology and lavage cytology, patients were classified into four risk groups: (A) no peritoneal disease, (B) CY+ who converted to negative lavage cytology (CY−) after neoadjuvant chemotherapy, (C) CY+ without conversion after chemotherapy, and (D) patients with visible peritoneal metastasis. Results Overall, n = 172 patients were included. At initial presentation, n = 125 (73%) had no peritoneal disease, and about a third of patients (n = 47, 27%) had microscopic or macroscopic peritoneal disease. Among them, n = 14 (8%) were CY+ without visible peritoneal metastasis, n = 9 converted to CY− after chemotherapy, and in n = 5 no conversion was observed. Median overall survival was not reached in patients who had initially no peritoneal disease and in patients who converted after chemotherapy, resulting in 3-year survival rates of 65% and 53%. In contrast, median overall survival was reduced to 13 months (95% CI 8.7–16.7) in patients without conversion and was 16 months (95% CI 12–20.5) in patients with peritoneal metastasis without difference between the two groups (p = .364). The conversion rate from CY+ to CY− was significantly higher after neoadjuvant treatment with FLOT (5-fluorouracil plus leucovorin, oxaliplatin, and docetaxel) compared to ECF (epirubicin, cisplatin, and 5-fluorouracil) (p = 0.027). Conclusion Conversion of CY+ to CY− after neoadjuvant chemotherapy with FLOT is a significant prognostic factor for a better overall survival. Surgical treatment in well-selected patients should therefore be considered. However, peritoneal recurrence remains frequent despite conversion, urging for a better local control.
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- 2021
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24. Are We Ready for Bariatric Surgery in a Liver Transplant Program? A Meta-Analysis
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Lopez-Lopez, Víctor, Ruiz-Manzanera, Juan José, Eshmuminov, Dilmurodjon, Lehmann, Kuno, Schneider, Marcel, von der Groeben, Markus, de Angulo, David Ruiz, Gajownik, Ursula, Pons, Jose Antonio, Sánchez-Bueno, Francisco, Robles-Campos, Ricardo, and Ramírez-Romero, Pablo
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- 2021
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25. Oligometastasiertes nichtkleinzelliges Lungenkarzinom: lokaltherapeutische Optionen zur Behandlung von Lungen- und Nebennierenmetastasen
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Guckenberger, Matthias, Lehmann, Kuno, and Opitz, Isabelle
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- 2020
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26. Gastric cancer with positive peritoneal cytology: survival benefit after induction chemotherapy and conversion to negative peritoneal cytology
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Valletti, Massimiliano, Eshmuminov, Dilmurodjon, Gnecco, Nicola, Gutschow, Christian Alexander, Schneider, Paul Magnus, and Lehmann, Kuno
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- 2021
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27. Diagnostic Nodes of Patient Selection for Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Among Colorectal Cancer Patients: A Swiss National Multicenter Survey
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Steffen, Thomas, Putora, Paul Martin, Hübner, Martin, Gloor, Beat, Lehmann, Kuno, Kettelhack, Christoph, Adamina, Michel, Peterli, Ralph, Schmidt, Jan, Ris, Frédéric, and Glatzer, Markus
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- 2019
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28. Standard Operating Procedures for Anesthesia Management in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improve Patient Outcomes: A Patient Cohort Analysis
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Fichmann, Dominique, Roth, Lilian, Raptis, Dimitri A., Kajdi, Marie-Elisabeth, Gertsch, Philippe, Vonlanthen, René, de Rougemont, Olivier, Moral, Julio, Beck-Schimmer, Beatrice, and Lehmann, Kuno
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- 2019
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29. 18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study
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Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras, and Kuno Lehmann
- Subjects
Histopathologic regression ,PET-CT ,Gastric cancer ,AEG ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction (AEG) cancer, the accuracy of FDG PET-CT to predict early pathologic response after neoadjuvant chemotherapy (neoCTX) is currently not known. Methods From a consecutive cohort of 72 patients, 44 patients with resectable, locally-advanced gastric cancer or AEG Siewert type II and III received neoCTX after primary staging with endoscopic ultrasound, PET-CT and laparoscopy. Overall, 14 patients did not show FDG uptake, and the remaining 30 were restaged by PET-CT 14 days after the first cycle of neoCTX. Metabolic response was defined as decrease of tumor standardized uptake value (SUV) by ≥35%. Major pathologic regression was defined as less than 10% residual tumor cells. Results Metabolic response after neoCTX was detected in 20/30 (66.7%), and non-response in 10/30 (33.3%) patients. Among metabolic responders, n = 10 (50%) showed major and n = 10 (50%) minor pathologic regression. In non-responders, n = 9 (90%) had minor and 1 (10%) a major pathologic regression. This resulted in a sensitivity of 90.9%, specificity 47.3%, positive predictive value 50%, negative predictive value 90% and accuracy of 63.3%. Conclusion Response PET-CT after the first cycle of neoCTX does not accurately predict overall pathologic response. However, PET-CT reliably detects non-responders, and identifies patients who should either immediately proceed to resection or receive a modified multimodality therapy. Trial registration The trial was registered and approved by local ethics committee PB_2016–00769.
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- 2018
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30. Intractable ascites associated with mycophenolate in a simultaneous kidney-pancreas transplant patient: a case report
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Nina T. Weber, Ali Sigaroudi, Alexander Ritter, Andreas Boss, Kuno Lehmann, David Goodman, Stefan Farese, Stefan Weiler, and Thomas F. Mueller
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Sodium mycophenolate ,Mycophenolic acid ,Ascites ,Transplantation ,Case report ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background Mycophenolic acid (MPA), either given as an ester pro-drug or as an enteric-coated sodium salt, is the most commonly prescribed anti-proliferative immunosuppressive agent used following organ transplantation and widely applied in immune-mediated diseases. Clinicians are well aware of common adverse reactions related to MPA treatment, in particular diarrhea, leukopenia and infections. Here we report a case of severe, persistent ascites associated with MPA treatment. The otherwise unexplained and intractable ascites, requiring repeated paracenteses for more than 8 months, rapidly ceased with stopping the MPA treatment. To our knowledge this is the first case of severe ascites associated with MPA treatment reported in the scientific literature. Case Presentation A 45-year old female with type 1 diabetes mellitus received a simultaneous kidney-pancreas transplant. The surgery was uneventful. However, post-operatively she developed severe transudative ascites requiring in total more than 40 paracenteses treatments draining in the average 2.8 l of ascites fluid. The ascites formation persisted despite exclusion of a surgical complication, fully functioning kidney and pancreas allografts, lack of any significant proteinuria, normalization of circulating albumin levels, intensive use of diuretics and deliberate attempts to increase the intervals between the paracentesis treatments. Various differential diagnoses, including infectious, hepatic, vascular and cardiac causes were ruled out. Nine months after surgery enteric-coated mycophenolate sodium was switched to azathioprine after which ascites completely resolved. When mycophenolate was recommenced abdominal fullness and weight gain reoccurred. The patient had to be switched to long-term azathioprine treatment. More than 1 year post-conversion the patient remains free of ascites. Conclusion MPA is the most widely used antimetabolite immunosuppressive agent. We suggest to consider MPA treatment in the differential diagnosis of severe and unexplained ascites in transplant and non-transplant patients.
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- 2017
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31. PD-L1 and HIF-2α Upregulation in Head and Neck Paragangliomas after Embolization.
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Fischer, Alessa, Maccio, Umberto, Wang, Katharina, Friemel, Juliane, Broglie Daeppen, Martina A., Vetter, Diana, Lehmann, Kuno, Reul, Astrid, Robledo, Mercedes, Hantel, Constanze, Bechmann, Nicole, Pacak, Karel, Zitzmann, Kathrin, Auernhammer, Christoph J., Grossman, Ashley B., Beuschlein, Felix, and Nölting, Svenja
- Subjects
PROTEINS ,KRUSKAL-Wallis Test ,PROGRAMMED death-ligand 1 ,IMMUNE checkpoint inhibitors ,IMMUNOHISTOCHEMISTRY ,HEAD & neck cancer ,THERAPEUTIC embolization ,PEARSON correlation (Statistics) ,COMPARATIVE studies ,CHI-squared test ,DESCRIPTIVE statistics ,PHEOCHROMOCYTOMA ,RESEARCH funding ,PARAGANGLIOMA ,DATA analysis software ,TUMOR markers ,HYPOXEMIA ,CELL death - Abstract
Simple Summary: In solid tumors, hypoxia activates pathways associated with tumor progression and induces alterations in the immune microenvironment such as the upregulation of programmed cell death-ligand 1 (PD-L1). Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors which are all considered to have metastatic potential independent of their initial clinical presentation. However, the relationship between hypoxia and PD-L1 regulation in PPGLs is still largely unexplored. We show that PD-L1 expression in head and neck paragangliomas (HNPGLs) undergoing embolization (median PD-L1 positivity: 15%) was significantly higher as compared to PD-L1 expression in HNPGLs without prior embolization (median PD-L1 positivity: 0%). Consistently, significantly more HNPGLs with embolization were positive for the hypoxia-marker HIF-2α (median nuclear HIF-2α positivity: 40%) as compared to HNPGLs without embolization (median nuclear HIF-2α positivity: 0%). Our findings suggest, that hypoxia leads to the upregulation of both PD-L1 and HIF-2α in HNPGLs, and may thus facilitate targeted treatment with HIF-2α and checkpoint inhibitors. Hypoxia activates pathways associated with tumor progression, metastatic spread, and alterations in the immune microenvironment leading to an immunosuppressive phenotype. In particular, the upregulation of PD-L1, a target for therapy with checkpoint inhibitors, is well-studied in several tumors. However, the relationship between hypoxia and PD-L1 regulation in pheochromocytomas and paragangliomas (PPGL), and especially in paragangliomas treated with embolization, is still largely unexplored. We investigated the expression of the hypoxia-marker HIF-2α and of PD-L1 in a PPGL-cohort with and without embolization as potential biomarkers that may predict the response to treatment with HIF-2α and checkpoint inhibitors. A total of 29 tumor samples from 25 patients who were operated at a single center were included and analyzed utilizing immunohistochemistry (IHC) for PD-L1 and HIF-2α. Embolization prior to surgery was performed in seven (24%) tumors. PD-L1 expression in tumor cells of head and neck paragangliomas (HNPGLs) receiving prior embolization (median PD-L1 positivity: 15%) was significantly higher as compared to PD-L1 expression in HNPGLs without prior embolization (median PD-L1 positivity: 0%) (p = 0.008). Consistently, significantly more HNPGLs with prior embolization were positive for HIF-2α (median nuclear HIF-2α positivity: 40%) as compared to HNPGLs without prior embolization (median nuclear HIF-2α positivity: 0%) (p = 0.016). Our results support the hypothesis that embolization with subsequent hypoxia leads to the upregulation of both PD-L1 and HIF-2α in HNPGLs, and could thus facilitate targeted treatment with HIF-2α and checkpoint inhibitors in the case of inoperable, locally advanced, or metastatic disease. [ABSTRACT FROM AUTHOR]
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- 2023
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32. Major Postoperative Complications Are a Risk Factor for Impaired Survival after CRS/HIPEC
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Schneider, Marcel André, Eshmuminov, Dilmurodjon, and Lehmann, Kuno
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- 2017
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33. Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice
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Rickenbacher, Andreas, Jang, Jae Hwi, Limani, Perparim, Ungethüm, Udo, Lehmann, Kuno, Oberkofler, Christian E., Weber, Achim, Graf, Rolf, Humar, Bostjan, and Clavien, Pierre-Alain
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- 2014
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34. Mutations of RAS/RAF Proto-oncogenes Impair Survival After Cytoreductive Surgery and HIPEC for Peritoneal Metastasis of Colorectal Origin
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Schneider, Marcel André, Eden, Janina, Pache, Basile, Laminger, Felix, Lopez-Lopez, Victor, Steffen, Thomas, Hübner, Martin, Kober, Friedrich, Roka, Sebastian, Campos, Pedro Cascales, Roth, Lilian, Gupta, Anurag, Siebenhüner, Alexander, Kepenekian, Vahan, Passot, Guillaume, Gertsch, Philippe, Glehen, Olivier, and Lehmann, Kuno
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- 2018
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35. 18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study
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Schneider, Paul M., Eshmuminov, Dilmurodjon, Rordorf, Tamara, Vetter, Diana, Veit-Haibach, Patrick, Weber, Achim, Bauerfeind, Peter, Samaras, Panagiotis, and Lehmann, Kuno
- Published
- 2018
- Full Text
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36. Where Oncologic and Surgical Complication Scoring Systems Collide: Time for a New Consensus for CRS/HIPEC
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Lehmann, Kuno, Eshmuminov, Dilmurodjon, Slankamenac, Ksenija, Kranzbühler, Benedict, Clavien, Pierre-Alain, Vonlanthen, René, and Gertsch, Philippe
- Published
- 2016
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37. Liver Failure After Extended Hepatectomy in Mice Is Mediated by a p21-Dependent Barrier to Liver Regeneration
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Lehmann, Kuno, Tschuor, Christoph, Rickenbacher, Andreas, Jang, Jae–Hwi, Oberkofler, Christian E., Tschopp, Oliver, Schultze, Simon M., Raptis, Dimitri A., Weber, Achim, Graf, Rolf, Humar, Bostjan, and Clavien, Pierre–Alain
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- 2012
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38. Trainee satisfaction in surgery residency programs: Modern management tools ensure trainee motivation and success
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von Websky, Martin W., Oberkofler, Christian E., Rufibach, Kaspar, Raptis, Dimitri A., Lehmann, Kuno, Hahnloser, Dieter, and Clavien, Pierre-Alain
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- 2012
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39. Current Research and Development in Hyperthermic Intraperitoneal Chemotherapy (HIPEC)—A Cross-Sectional Analysis of Clinical Trials Registered on ClinicalTrials.gov.
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Ukegjini, Kristjan, Guidi, Marisa, Lehmann, Kuno, Süveg, Krisztian, Putora, Paul Martin, Cihoric, Nikola, and Steffen, Thomas
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ADJUVANT chemotherapy ,DISEASE progression ,STOMACH tumors ,THERMOTHERAPY ,OVARIAN tumors ,PERITONEAL cancer ,SYSTEMATIC reviews ,CROSS-sectional method ,TREATMENT effectiveness ,COLORECTAL cancer ,DESCRIPTIVE statistics ,CYTOREDUCTIVE surgery ,MEDICAL research ,CLINICAL trial registries ,EVALUATION - Abstract
Simple Summary: Peritoneal metastases have a poor prognosis, and one potential treatment option is cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). The specific role of HIPEC is still poorly defined. In this cross-sectional study, we systematically analyzed all HIPEC trials registered on ClinicalTrials.gov to identify current research areas and to provide a perspective on expected outcomes. Only 11% (n = 26) of HIPEC trials registered on ClinicalTrials.gov (n = 234) have been published. The registered trials are very heterogeneous regarding methodological approaches and study designs. Currently, research is being conducted on 20 different drugs. The most studied cancers in HIPEC trials are peritoneal metastatic colorectal tumors, gastric cancer, and ovarian cancer. Introduction: Over the past two decades, cytoreductive surgery and HIPEC has improved outcomes for selected patients with peritoneal metastasis from various origins. This is a cross-sectional study with descriptive analyses of HIPEC trials registered on ClinicalTrials.gov. This study aimed to characterize clinical trials on HIPEC registered on ClinicalTrials.gov with the primary objective of identifying a trial focus and to examine whether trial results were published. Methods: The search included trials registered from 1 January 2001 to 14 March 2022. We examined the associations of exposure variables and other trial features with two primary outcomes: therapeutic focus and results reporting. Results: In total, 234 clinical trials were identified; 26 (11%) were already published, and 15 (6%) trials have reported their results but have not been published as full papers. Among ongoing nonpublished trials, 81 (39%) were randomized, 30 (14%) were blinded, n = 39 (20%) were later phase trials (i.e., phases 3 and 4), n = 152 (73%) were from a single institution, and 91 (44%) had parallel groups. Most of the trials were recruiting at the time of this analysis (75, 36%), and 39 (20%) were completed but had yet to publish results. In total, 68% of the trials focused on treatment strategies, and 53% investigated the oncological outcome. The most studied neoplasms for HIPEC trials were peritoneally metastasized colorectal cancer (32%), gastric cancer (29%), and ovarian cancer (26%). Twenty different drugs were analyzed in these clinical trials. Conclusions: Many study results are awaited from ongoing HIPEC trials. Most HIPEC trials focused on gastric, colorectal, or ovarian cancer. Many clinical trials were identified involving multiple entities and chemotherapeutic agents. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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40. History of Hepatic Surgery
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Lehmann, Kuno and Clavien, Pierre-Alain
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- 2010
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41. Clamping techniques and protecting strategies in liver surgery
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Lesurtel, Mickael, Lehmann, Kuno, De Rougemont, Olivier, and Clavien, Pierre-Alain
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- 2009
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42. Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice
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Oberkofler, Christian E., Limani, Perparim, Jang, Jae-Hwi, Rickenbacher, Andreas, Lehmann, Kuno, Raptis, Dimitri A., Ungethuem, Udo, Tian, Yinghua, Grabliauskaite, Kamile, Humar, Rok, Graf, Rolf, Humar, Bostjan, and Clavien, Pierre-Alain
- Published
- 2014
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43. Clinical and Morphologic Correlation after Stapled Transanal Rectal Resection for Obstructed Defecation Syndrome
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Dindo, Daniel, Weishaupt, Dominik, Lehmann, Kuno, Hetzer, Franc H., Clavien, Pierre-Alain, and Hahnloser, Dieter
- Published
- 2008
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44. Comprehensive Treatment Algorithms of the Swiss Peritoneal Cancer Group for Peritoneal Cancer of Gastrointestinal Origin.
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Adamina, Michel, Warlaumont, Maxime, Berger, Martin D., Däster, Silvio, Delaloye, Raphaël, Digklia, Antonia, Gloor, Beat, Fritsch, Ralph, Koeberle, Dieter, Koessler, Thibaud, Lehmann, Kuno, Müller, Phaedra, Peterli, Ralph, Ris, Frédéric, Steffen, Thomas, Weisshaupt, Christian Stefan, and Hübner, Martin
- Subjects
ADJUVANT chemotherapy ,MESOTHELIOMA ,THERMOTHERAPY ,EARLY detection of cancer ,CANCER patients ,PERITONEUM tumors ,GASTROINTESTINAL tumors ,MEDICAL protocols ,HEALTH care teams ,COMBINED modality therapy ,CYTOREDUCTIVE surgery ,ALGORITHMS ,PALLIATIVE treatment ,CLINICAL trial registries - Abstract
Simple Summary: Peritoneal cancer is best addressed by a multimodal treatment approach, including cytoreductive surgery, systemic immunochemotherapy, and intraperitoneal chemotherapy (HIPEC, PIPAC). The present Swiss Peritoneal Cancer Group comprehensive treatment algorithms offer consensus guidance for interdisciplinary care of patients with peritoneal cancer from pseudomyxoma peritonei, peritoneal mesothelioma, gastric, and colorectal origin. They include straight complete surgical resection, multimodal neoadjuvant treatment, HIPEC and PIPAC, and referral to palliative care. These state-of-the-art algorithms have been endorsed by all Swiss clinicians routinely involved in the multimodal care of patients with peritoneal cancer of gastrointestinal origin. Peritoneal cancer (PC) is a dire finding, yet in selected patients, long-term survival is possible. Complete cytoreductive surgery (CRS) together with combination immunochemotherapy is essential to achieve cure. Hyperthermic intraperitoneal chemotherapy (HIPEC) and pressurized intraperitoneal aerosol chemotherapy (PIPAC) are increasingly added to the multimodal treatment. The Swiss Peritoneal Cancer Group (SPCG) is an interdisciplinary group of expert clinicians. It has developed comprehensive treatment algorithms for patients with PC from pseudomyxoma peritonei, peritoneal mesothelioma, gastric, and colorectal origin. They include multimodal neoadjuvant treatment, surgical resection, and palliative care. The indication for and results of CRS HIPEC and PIPAC are discussed in light of the current literature. Institutional volume and clinical expertise required to achieve best outcomes are underlined, while inclusion of patients considered for CRS HIPEC and PIPAC in a clinical registry is strongly advised. The present recommendations are in line with current international guidelines and provide the first comprehensive treatment proposal for patients with PC including intraperitoneal chemotherapy. The SPCG comprehensive treatment algorithms provide evidence-based guidance for the multimodal care of patients with PC of gastrointestinal origin that were endorsed by all Swiss clinicians routinely involved in the multimodal care of these challenging patients. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
45. γ-Radiation promotes immunological recognition of cancer cells through increased expression of cancer-testis antigens in vitro and in vivo.
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Anu Sharma, Beata Bode, Roland H Wenger, Kuno Lehmann, Alessandro A Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer, and Maries van den Broek
- Subjects
Medicine ,Science - Abstract
BACKGROUND: γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore investigated whether γ-radiation results in increased expression of cancer-testis (CT) antigens and MHC-I, thus allowing efficient immunological control. This is relevant because the expression of CT-antigens and MHC-I on tumor cells is often heterogeneous. We found that the changes induced by γ-radiation promote the immunological recognition of the tumor, which is illustrated by the increased infiltration by lymphocytes after radiotherapy. METHODS/FINDINGS: We compared the expression of CT-antigens and MHC-I in various cancer cell lines and fresh biopsies before and after in vitro irradiation (20 Gy). Furthermore, we compared paired biopsies that were taken before and after radiotherapy from sarcoma patients. To investigate whether the changed expression of CT-antigens and MHC-I is specific for γ-radiation or is part of a generalized stress response, we analyzed the effect of hypoxia, hyperthermia and genotoxic stress on the expression of CT-antigens and MHC-I. In vitro irradiation of cancer cell lines and of fresh tumor biopsies induced a higher or de novo expression of different CT-antigens and a higher expression of MHC-I in a time- and dose-dependent fashion. Importantly, we show that irradiation of cancer cells enhances their recognition by tumor-specific CD8+ T cells. The analysis of paired biopsies taken from a cohort of sarcoma patients before and after radiotherapy confirmed our findings and, in addition showed that irradiation resulted in higher infiltration by lymphocytes. Other forms of stress did not have an impact on the expression of CT-antigens or MHC-I. CONCLUSIONS: Our findings suggest that γ-radiation promotes the immunological recognition of the tumor. We therefore propose that combining radiotherapy with treatments that support tumor specific immunity may result in increased therapeutic efficacy.
- Published
- 2011
- Full Text
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46. Long-term outcomes of transplant kidneys donated after circulatory death.
- Author
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Müller, Amélie K, Breuer, Eva, Hübel, Kerstin, Lehmann, Kuno, Cippà, Pietro, Schachtner, Thomas, Oberkofler, Christian, Müller, Thomas, Weber, Markus, Dutkowski, Philipp, Clavien, Pierre-Alain, and Rougemont, Olivier de
- Subjects
KIDNEY transplantation ,TREATMENT effectiveness ,GRAFT survival ,GLOMERULAR filtration rate ,BRAIN death - Abstract
Background Donation after circulatory death (DCD) represents up to 40% of used kidney grafts. While studies have shown similar outcomes compared with donation after brain death (DBD) in the short term and mid-term, no data on long-term outcomes exist. Methods We retrospectively analysed patients transplanted at our institution between January 1985 and March 2000. All DCD recipients were matched one-to-one with patients transplanted with DBD grafts during this period according to sex, age and year of transplantation and followed up until December 2020. During this period, 1133 kidney transplantations were performed, of which 122 were with a DCD graft. Results The median graft survival after 35 years of follow-up was 23 years [277 months {95% confidence interval (CI) 182–372}] in DBD recipients and 24.5 years [289 months (95% CI 245–333)] in DCD recipients (P = 0.65; hazard ratio 0.91). Delayed graft function occurred in 47 patients in the DCD group compared with 23 in the DBD group (P < 0.001), albeit without a significant long-term outcome difference in graft or patient survival. We could not show any difference in graft function in terms of creatinine levels (133 versus 119 µmol/L), proteinuria (370 versus 240 mg/24 h) and glomerular filtration rate slope (–0.6 versus –0.3 mL/min/year) between the two groups for graft survival >20 years. Conclusions This is the first study to show similar graft survival and function in DCD kidneys compared with DBD kidneys after 35 years of follow-up. DCD grafts are a valuable resource and can be utilized in the same way as DBD grafts. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
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47. Mitigation of the Small for Size Syndrome through hepatic hyperplasia induced by constitutive androstane receptor agonism: 262
- Author
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Tschuor, Christoph, Schlegel, Andrea, Kachaylo, Ekaterina, Jang, Jae Hwi, Raptis, Dimitri A., Limani, Perparim, Melloul, Emmanuel, Lehmann, Kuno, Tian, Yinghua, Humar, Bostjan, Graf, Rolf, and Clavien, Pierre A.
- Published
- 2012
48. Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation
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Jang, Jae-Hwi, Rickenbacher, Andreas, Humar, Bostjan, Weber, Achim, Raptis, Dimitri Aristotle, Lehmann, Kuno, Stieger, Bruno, Moritz, Wolfgang, Soll, Christopher, Georgiev, Panco, Fischer, David, Laczko, Endre, Graf, Rolf, and Clavien, Pierre-Alain
- Published
- 2012
- Full Text
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49. Treatment of ureteral complications after kidney transplantation with native ureteropyelostomy reduces the risk of pyelonephritis
- Author
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Lehmann, Kuno, Müller, Markus K., Schiesser, Marc, Wildi, Stefan, Fehr, Thomas, Wüthrich, Rudolf P., Clavien, Pierre-Alain, and Weber, Markus
- Published
- 2011
- Full Text
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50. Preconditioning, organ preservation, and postconditioning to prevent ischemia-reperfusion injury to the liver
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de Rougemont, Olivier, Lehmann, Kuno, and Clavien, Pierre-Alain
- Published
- 2009
- Full Text
- View/download PDF
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