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1,266 results on '"Le Cesne, A."'

1. Ripretinib versus sunitinib in gastrointestinal stromal tumor: ctDNA biomarker analysis of the phase 3 INTRIGUE trial

Author

Heinrich, Michael C., Jones, Robin L., George, Suzanne, Gelderblom, Hans, Schöffski, Patrick, von Mehren, Margaret, Zalcberg, John R., Kang, Yoon-Koo, Razak, Albiruni Abdul, Trent, Jonathan, Attia, Steven, Le Cesne, Axel, Siontis, Brittany L., Goldstein, David, Boye, Kjetil, Sanchez, Cesar, Steeghs, Neeltje, Rutkowski, Piotr, Druta, Mihaela, Serrano, César, Somaiah, Neeta, Chi, Ping, Reichmann, William, Sprott, Kam, Achour, Haroun, Sherman, Matthew L., Ruiz-Soto, Rodrigo, Blay, Jean-Yves, and Bauer, Sebastian

Published
2024
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3. Regorafenib in patients with advanced Ewing sarcoma: results of a non-comparative, randomised, double-blind, placebo-controlled, multicentre Phase II study

Author

Duffaud, Florence, Blay, Jean-Yves, Le Cesne, Axel, Chevreau, Christine, Boudou-Rouquette, Pascaline, Kalbacher, Elsa, Penel, Nicolas, Perrin, Christophe, Laurence, Valérie, Bompas, Emmanuelle, Saada-Bouzid, Esma, Delcambre, Corinne, Bertucci, François, Cancel, Mathilde, Schiffler, Camille, Monard, Laure, Bouvier, Corinne, Vidal, Vincent, Gaspar, Nathalie, and Chabaud, Sylvie

Published
2023
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6. Why cave planthoppers study matters: are Cixiidae a subtroglophile lineage? (Hemiptera, Fulgoromorpha)

Author

Maxime Le Cesne, Hannelore Hoch, Yalin Zhang, and Thierry Bourgoin

Subjects
Biology (General), QH301-705.5
Abstract

Planthoppers are an interesting and contrasting model among insects for studying the subterranean environments. Their morphological and ethological adaptations to the underground conditions (complete darkness, lower temperatures, high hygrometry, stability of environmental constants, rarefied food sources, etc.), and their worldwide distribution in both temperate and tropical areas make them an interesting model among invertebrates. In this review, we highlight why cave planthoppers study matters, with particular emphasis on the Cixiidae. The two hypotheses proposed, the ‘climatic relict hypothesis’ and the ‘adaptive shift’, are not sufficient enough to clearly understand and explain the drivers to cavernicoly. Phylogenetic analyses approaches might help to better document and increase our knowledge on such peculiar environments. The singularity of the distribution pattern of the adaptation to cavernicoly in planthoppers raises also interesting questions to investigate and suggest contrasting scenarios to explore further, particularly should the Cixiidae be defined as a subtroglophile lineage?

Published
2024
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7. Malagasy spittlebugs (Hemiptera: Cercopidae), a taxonomic review of genera from Madagascar

Author

Manon Bucher, Émilien Bouteille, and Maxime Le Cesne

Subjects
Spittlebugs, Cercopidae, Madagascar, new species, new genus, Zoology, QL1-991, Botany, QK1-989
Abstract

The nine genera of Malagasy spittlebug are revised, with the addition of new characters, facilitating the identification of the species. Nesaulax Jacobi, 1917, is synonymized with Amberana Distant, 1908, leading to a new combination for Amberana vittipennis (Bergroth, 1894). A new endemic genus Soulierana Bucher & Bouteille gen. nov. is proposed for two species originally placed in Literna Stål, 1866, based on morphological characters of the head, tegmina and male genitalia. Also, three new species are described in this genus: Soulierana bigidea Bucher gen. et sp. nov., Soulierana claudinae Bouteille gen. et sp. nov. and Soulierana kelymena Le Cesne gen. et sp. nov. Pictures of species and drawings of the male genitalia for all genera, with the exception of Rhinaulax Amyot & Serville, 1843, Alluaudensia Lallemand, 1920 and Literna, are included. An identification key is available in both a dichotomous format and an interactive format (Xper3).

Published
2024
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8. Selinexor in Advanced, Metastatic Dedifferentiated Liposarcoma: A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial

Author

Gounder, Mrinal M, Razak, Albiruni Abdul, Somaiah, Neeta, Chawla, Sant, Martin-Broto, Javier, Grignani, Giovanni, Schuetze, Scott M, Vincenzi, Bruno, Wagner, Andrew J, Chmielowski, Bartosz, Jones, Robin L, Riedel, Richard F, Stacchiotti, Silvia, Loggers, Elizabeth T, Ganjoo, Kristen N, Le Cesne, Axel, Italiano, Antoine, del Muro, Xavier Garcia, Burgess, Melissa, Piperno-Neumann, Sophie, Ryan, Christopher, Mulcahy, Mary F, Forscher, Charles, Penel, Nicolas, Okuno, Scott, Elias, Anthony, Hartner, Lee, Philip, Tony, Alcindor, Thierry, Kasper, Bernd, Reichardt, Peter, Lapeire, Lore, Blay, Jean-Yves, Chevreau, Christine, Morales, Claudia Maria Valverde, Schwartz, Gary K, Chen, James L, Deshpande, Hari, Davis, Elizabeth J, Nicholas, Garth, Gröschel, Stefan, Hatcher, Helen, Duffaud, Florence, Herráez, Antonio Casado, Beveridge, Roberto Diaz, Badalamenti, Giuseppe, Eriksson, Mikael, Meyer, Christian, von Mehren, Margaret, Van Tine, Brian A, Götze, Katharina, Mazzeo, Filomena, Yakobson, Alexander, Zick, Aviad, Lee, Alexander, Gonzalez, Anna Estival, Napolitano, Andrea, Dickson, Mark A, Michel, Dayana, Meng, Changting, Li, Lingling, Liu, Jianjun, Ben-Shahar, Osnat, Van Domelen, Dane R, Walker, Christopher J, Chang, Hua, Landesman, Yosef, Shah, Jatin J, Shacham, Sharon, Kauffman, Michael G, and Attia, Steven

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Genetics, Clinical Trials and Supportive Activities, Patient Safety, 6.1 Pharmaceuticals, Cancer, Child, Double-Blind Method, Humans, Hydrazines, Liposarcoma, Triazoles, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

PurposeAntitumor activity in preclinical models and a phase I study of patients with dedifferentiated liposarcoma (DD-LPS) was observed with selinexor. We evaluated the clinical benefit of selinexor in patients with previously treated DD-LPS whose sarcoma progressed on approved agents.MethodsSEAL was a phase II-III, multicenter, randomized, double-blind, placebo-controlled study. Patients age 12 years or older with advanced DD-LPS who had received two-five lines of therapy were randomly assigned (2:1) to selinexor (60 mg) or placebo twice weekly in 6-week cycles (crossover permitted). The primary end point was progression-free survival (PFS). Patients who received at least one dose of study treatment were included for safety analysis (ClinicalTrials.gov identifier: NCT02606461).ResultsTwo hundred eighty-five patients were enrolled (selinexor, n = 188; placebo, n = 97). PFS was significantly longer with selinexor versus placebo: hazard ratio (HR) 0.70 (95% CI, 0.52 to 0.95; one-sided P = .011; medians 2.8 v 2.1 months), as was time to next treatment: HR 0.50 (95% CI, 0.37 to 0.66; one-sided P < .0001; medians 5.8 v 3.2 months). With crossover, no difference was observed in overall survival. The most common treatment-emergent adverse events of any grade versus grade 3 or 4 with selinexor were nausea (151 [80.7%] v 11 [5.9]), decreased appetite (113 [60.4%] v 14 [7.5%]), and fatigue (96 [51.3%] v 12 [6.4%]). Four (2.1%) and three (3.1%) patients died in the selinexor and placebo arms, respectively. Exploratory RNA sequencing analysis identified that the absence of CALB1 expression was associated with longer PFS with selinexor compared with placebo (median 6.9 v 2.2 months; HR, 0.19; P = .001).ConclusionPatients with advanced, refractory DD-LPS showed improved PFS and time to next treatment with selinexor compared with placebo. Supportive care and dose reductions mitigated side effects of selinexor. Prospective validation of CALB1 expression as a predictive biomarker for selinexor in DD-LPS is warranted.

Published
2022

9. Investigating the prognostic impact of NY-ESO-1 expression and HLA subtypes in metastatic synovial sarcoma

Author

Dufresne, A., Pokras, S., Meurgey, A., Chabaud, S., Toulmonde, M., Bompas, E., Le Cesne, A., Robin, Y.-M., Duffaud, F., Valentin, T., El Zein, S., Leroux, A., Dubray-Longeras, P., Firmin, N., de Pinieux, G., Noal, S., Delfour, C., Bollard, J., Tonon, L., Biette, A., Gadot, N., Attignon, V., Jean-Denis, M., Woessner, M., Klohe, E., Thayaparan, T., Eleftheriadou, I., Blouch, K., Nathenson, M.J., and Blay, J.-Y.

Published
2024
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10. Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Author

Loong, Herbert, Brunello, Antonella, Krieg, Andreas, Algulnik, Mark, Riedel, Richard, Okuno, Scott, Loggers, Elizabeth, Alcindor, Thierry, Ferraresi, Virginia, Serrano, César, Randall, R. Lor, Wilky, Breelyn, Ravi, Vinod, Gelderblom, Hans, Bhadri, Vivek, Stacchiotti, Silvia, Bauer, Sebastian, Wagner, Andrew J, van de Sande, Michiel, Bernthal, Nicholas M, López Pousa, Antonio, Razak, Albiruni Abdul, Italiano, Antoine, Ahmed, Mahbubl, Le Cesne, Axel, Tinoco, Gabriel, Boye, Kjetil, Martín-Broto, Javier, Palmerini, Emanuela, Tafuto, Salvatore, Pratap, Sarah, Powers, Benjamin C, Reichardt, Peter, Casado Herráez, Antonio, Rutkowski, Piotr, Tait, Christopher, Zarins, Fiona, Harrow, Brooke, Sharma, Maitreyi G, Ruiz-Soto, Rodrigo, Sherman, Matthew L, Blay, Jean-Yves, and Tap, William D

Published
2024
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11. Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs

Author

Henon, Clémence, Vibert, Julien, Eychenne, Thomas, Gruel, Nadège, Colmet-Daage, Léo, Ngo, Carine, Garrido, Marlène, Dorvault, Nicolas, Marques Da Costa, Maria Eugenia, Marty, Virginie, Signolle, Nicolas, Marchais, Antonin, Herbel, Noé, Kawai-Kawachi, Asuka, Lenormand, Madison, Astier, Clémence, Chabanon, Roman, Verret, Benjamin, Bahleda, Rastislav, Le Cesne, Axel, Mechta-Grigoriou, Fatima, Faron, Matthieu, Honoré, Charles, Delattre, Olivier, Waterfall, Joshua J., Watson, Sarah, and Postel-Vinay, Sophie

Published
2024
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12. Afamitresgene autoleucel for advanced synovial sarcoma and myxoid round cell liposarcoma (SPEARHEAD-1): an international, open-label, phase 2 trial

Author

D'Angelo, Sandra P, Araujo, Dejka M, Abdul Razak, Albiruni R, Agulnik, Mark, Attia, Steven, Blay, Jean-Yves, Carrasco Garcia, Irene, Charlson, John A, Choy, Edwin, Demetri, George D, Druta, Mihaela, Forcade, Edouard, Ganjoo, Kristen N, Glod, John, Keedy, Vicki L, Le Cesne, Axel, Liebner, David A, Moreno, Victor, Pollack, Seth M, Schuetze, Scott M, Schwartz, Gary K, Strauss, Sandra J, Tap, William D, Thistlethwaite, Fiona, Valverde Morales, Claudia Maria, Wagner, Michael J, Wilky, Breelyn A, McAlpine, Cheryl, Hudson, Laura, Navenot, Jean-Marc, Wang, Tianjiao, Bai, Jane, Rafail, Stavros, Wang, Ruoxi, Sun, Amy, Fernandes, Lilliam, Van Winkle, Erin, Elefant, Erica, Lunt, Colin, Norry, Elliot, Williams, Dennis, Biswas, Swethajit, and Van Tine, Brian A

Published
2024
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14. Improved nationwide survival of sarcoma patients with a network of reference centers

Author

Blay, J.Y., Penel, N., Valentin, T., Anract, P., Duffaud, F., Dufresne, A., Verret, B., Cordoba, A., Italiano, A., Brahmi, M., Henon, C., Amouyel, T., Ray-Coquard, I., Ferron, G., Boudou-Rouquette, P., Tlemsani, C., Salas, S., Rochwerger, R., Faron, M., Bompas, E., Ducassou, A., Gangloff, D., Gouin, F., Firmin, N., Piperno-Neumann, S., Rios, M., Ropars, M., Kurtz, J.E., Le Nail, L.R., Bertucci, F., Carrere, S., Llacer, C., Watson, S., Bonvalot, S., Leroux, A., Perrin, C., Gantzer, J., Pracht, M., Narciso, B., Monneur, A., Lebbe, C., Hervieu, A., Saada-Bouzid, E., Dubray-Longeras, P., Fiorenza, F., Chaigneau, L., Nevieres, Z.-M., Soibinet, P., Bouché, O., Guillemet, C., Spano, J.P., Ruzic, J.C., Isambert, N., Vaz, G., Meeus, P., Karanian, M., Ngo, C., Coindre, J.M., De Pinieux, G., Le Loarer, F., Ducimetiere, F., Chemin, C., Morelle, M., Toulmonde, M., and Le Cesne, A.

Published
2024
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16. A randomized study of 6 versus 3 years of adjuvant imatinib in patients with localized GIST at high risk of relapse

Author

Blay, J.-Y., Schiffler, C., Bouché, O., Brahmi, M., Duffaud, F., Toulmonde, M., Landi, B., Lahlou, W., Pannier, D., Bompas, E., Bertucci, F., Chaigneau, L., Collard, O., Pracht, M., Henon, C., Ray-Coquard, I., Armoun, K., Salas, S., Spalato-Ceruso, M., Adenis, A., Verret, B., Penel, N., Moreau-Bachelard, C., Italiano, A., Dufresne, A., Metzger, S., Chabaud, S., Perol, D., and Le Cesne, A.

Published
2024
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17. Sclerosing Epithelioid Fibrosarcoma (SEF) versus Low Grade Fibromyxoid Sarcoma (LGFMS): Presentation and outcome in the nationwide NETSARC+ series of 330 patients over 13 years

Author

Blay, JY, Tlemsani, C., Toulmonde, M., Italiano, A., Rios, M., Bompas, E., Valentin, T., Duffaud, F., Le Nail, LR, Watson, S., Firmin, N., Dubray-Longeras, P., Ropars, M., Perrin, C., Hervieu, A., Lebbe, C., Saada-Bouzid, E., Soibinet, P., Fiorenza, F., Bertucci, F., Boudou, P., Vaz, G., Bonvalot, S., Honoré, C., Marec-Berard, P., Minard, V., Cleirec, M., Biau, D., Meeus, P., Babinet, A., Dumaine, V., Carriere, S., Fau, M., Decanter, G., Gouin, F., Ngo, C., Le Loarer, F., Karanian, M., Meurgey, A., Dufresne, A., Brahmi, M., Chemin-Airiau, C., Ducimetiere, F., Penel, N., and Le Cesne, A.

Published
2024
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19. Prognostic factors of the synovial sarcoma of the extremities: imaging does matter

Author

Tordjman, Mickael, Honoré, Charles, Crombé, Amandine, Bouhamama, Amine, Feydy, Antoine, Dercle, Laurent, Haddag, Leila, Bouché, Pierre-Alban, Ngo, Carine, Le Cesne, Axel, Blay, Jean-Yves, Mir, Olivier, Brahmi, Mehdi, Martin, Charlotte, Karanian, Marie, Ammari, Samy, Kind, Michele, Audard, Virginie, Le Loarer, François, Rabiee, Behnam, Italiano, Antoine, Boudou-Rouquette, Pascaline, Biau, David, Balleyguier, Corinne, Larousserie, Frederique, Drapé, Jean-Luc, and Mihoubi, Fadila

Published
2023
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20. Handling missing covariates in observational studies: an illustration with the assessment of prognostic factors of survival outcomes in soft-tissue or visceral sarcomas in irradiated fields (SIF)

Author

Noémie Huchet, Nicolas Penel, Sylvie Bonvalot, Juliette Thariat, Françoise Ducimetière, Antoine Giraud, Maud Toulmonde, Axel Le Cesne, Jean-Yves Blay, and Carine Bellera

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Missing covariates are common in observational research and can lead to bias and loss of statistical power. Limited data regarding prognostic factors of survival outcomes of sarcomas in irradiated fields (SIF) are available. Because of the long lag time between irradiation of first cancer and scarcity of SIF, missing data are a critical issue when analyzing long-term outcomes. We assessed prognostic factors of overall (OS), progression-free (PFS), and metastatic-progression-free (MPFS) survivals in SIF using three methods to account for missing covariates. Methods: We relied on the NETSARC French Sarcoma Group database, Cox (OS/PFS), and competitive hazards (MPFS) survival models. Covariates investigated were age, sex, histological subtype, tumor size, depth and grade, metastasis, surgery, surgical resection, surgeon’s expertise, imaging, and neo-adjuvant treatment. We first applied multiple imputation (MI): observed data were used to estimate the missing covariate. With the missing-data modality approach, a category missing was created for qualitative variables. With the complete-case (CC) approach, analysis was restricted to patients without missing covariates. Results: CC subjects ( N = 167; 33%) presented more often with soft-tissue sarcoma ( versus visceral sarcoma) and grade I–II tumors as compared to the 504 eligible cases. With MI ( N = 504), factors associated with the worst outcome included metastasis ( p = 0.04) and R1/R2 resection ( p < 0.001) for OS; higher grade/non-gradable tumors ( p = 0.002) and R1/R2 resection ( p < 0.001) for PFS; and metastasis ( p = 0.01) for M-PFS. The ‘missing-data modality’ approach ( N = 504) led to different associations, including significance reached due to variables with the modality ‘missing’. The CC analysis led to different results and reduced precision. Conclusion: The CC population was not representative of the eligible population, introducing bias, in addition to worst precision. The ‘missing-data modality method’ results in biased estimates in non-randomized studies, as outcomes may be related to variables with missing values. Appropriate statistical methods for missing covariates, for example, MI, should therefore be considered.

Published
2024
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21. Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience

Author

Anne-Laure Genevois, Matthieu Carton, Myriam Jean-Denis, Joanna Cyrta, Nadège Corradini, Pablo Berlanga, Claire Chemin-Airiau, Charles Honore, Sophie El Zein, Anne-Sophie Defachelles, Emmanuelle Bompas, Philippe Anract, Justine Gantzer, Marie Karanian, Angélique Rome, Florence Duffaud, Christine Chevreau, Sarah Watson, Axel Le Cesne, Carmen Llacer, François Le Loarer, Gaëlle Pierron, François Gouin, Anne Gomez-Mascard, Sylvain Causeret, Françoise Ducimetière, Elsa Kalbacher, Maud Toulmonde, Jean-Yves Blay, and Daniel Orbach

Subjects
Liposarcoma, Leiomyosarcoma, Ultra-rare sarcoma, Children, Adolescent-young adults, NETSARC+, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Leiomyosarcoma (LMS) and liposarcoma (LPS) are ultra-rare sarcomas in pediatric (0–18 years) and young adult (19−30) populations. We aimed to analyze their clinical characteristics at these young ages and to determine whether they should be considered with the same therapeutic strategy in both populations. Methods: National retrospective multicenter study of all young patients (0–30 years) included in the sarcoma database “ConticaBase”, treated for LMS or LPS between 2010 and 2019 via the national NETSARC+ network, with available pathology/biology review. Findings: A total of 218 patients were identified, 34 children (nine LMS, 25 LPS) and 184 young adults (58 LMS, 126 LPS). Myxoid/Round Cell LPS (M/RC-LPS) was the most frequent LPS subtype (72 %). All children had localized LMS and LPS, versus 52/58 and 116/126 respectively in adults. Clinical presentation of LMS and all LPS subtypes was comparable in both populations, except for a preferential limb location of LMS in children. The therapeutic strategy was mainly based on primary surgery in LMS (9/9 children, 52/58 adults) and for LPS (respectively 25/25 and 122/126), exclusively or with adjuvant radiotherapy and systemic treatment. With a median follow-up of 62.4 months (range, 2.5–146), 5-year overall survival was respectively 83 % [95 % CI, 58–100] in children and 73 % [61–88] in young adults for LMS, 100 % [100] vs 92 % [87–99] for M/RC-LPS and 25 % [5–100] vs 60 % [29–100] for pleomorphic LPS. Interpretation: LMS and all LPS subtypes appear to display comparable behavior in children and young adults. The authors propose that the same therapeutic strategy should be considered for both groups.

Published
2023
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22. Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience

Author

Genevois, Anne-Laure, Carton, Matthieu, Jean-Denis, Myriam, Cyrta, Joanna, Corradini, Nadège, Berlanga, Pablo, Chemin-Airiau, Claire, Honore, Charles, El Zein, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Anract, Philippe, Gantzer, Justine, Karanian, Marie, Rome, Angélique, Duffaud, Florence, Chevreau, Christine, Watson, Sarah, Le Cesne, Axel, Llacer, Carmen, Le Loarer, François, Pierron, Gaëlle, Gouin, François, Gomez-Mascard, Anne, Causeret, Sylvain, Ducimetière, Françoise, Kalbacher, Elsa, Toulmonde, Maud, Blay, Jean-Yves, and Orbach, Daniel

Published
2023
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24. Single‐agent gemcitabine in patients with advanced, pre‐treated angiosarcoma: A multicenter, retrospective study

Author

Sarah Watson, Benjamin Verret, Stanislas Ropert, Julien Adam, Rastislav Bahleda, Sylvain Briand, Andrea Cavalcanti, Ali N. Chamseddine, Charles Court, Elie Fadel, Matthieu Faron, Leila Haddag‐Miliani, Clémence Henon, Cécile Le Pechoux, Antonin Levy, Olaf Mercier, Carine Ngo, Charles Honoré, Axel Le Cesne, and Olivier Mir

Subjects
angiosarcoma, cardiac sarcoma, gemcitabine, sarcoma, soft tissue neoplasms, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Gemcitabine has shown clinical activity against angiosarcoma in small series, alone, or combined with taxanes. We aimed to evaluate its activity as a single‐agent in a larger series of patients with advanced angiosarcoma. We retrospectively reviewed the electronic medical records of consecutive adult patients with advanced angiosarcoma treated with single‐agent gemcitabine at our institutions from January 2010 to January 2021. Response was evaluated according to RECIST 1.1, and toxicity was graded according to NCI‐CTC v5.0. 42 patients were identified. 38 patients (90%) had received prior anthracyclines and weekly paclitaxel, and 9 (21%) had received pazopanib. The best tumor response was partial response (PR) in 16 patients (38%), or stable disease (10 patients, 24%). All 8 patients with cardiac angiosarcoma experienced a PR. Median PFS was 5.4 months (95%CI: 3.1–6.5), and median OS was 9.9 months (95%CI: 6.6–13.4). Single‐agent gemcitabine has clinically meaningful activity in advanced, heavily pre‐treated angiosarcoma.

Published
2023
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25. Epithelioid hemangio-endothelioma (EHE) in NETSARC: The nationwide series of 267 patients over 12 years

Author

Blay, JY, Piperno-Neumann, S., Watson, S., Dufresne, A., Valentin, T., Duffaud, F., Toulmonde, M., Italiano, A., Bertucci, F., Tlemsani, C., Firmin, N., Bompas, E., Perrin, C., Ropars, M., Saada-Bouzid, E., Dubray-Longeras, P., Hervieu, A., Lebbe, C., Gantzer, J., Chaigneau, L., Fiorenza, F., Rios, M., Isambert, N., Soibinet, P., Boudou-Roquette, P., Verret, B., Ferron, G., Ryckewaert, T., Lebellec, L., Brahmi, M., Gouin, F., Meeus, P., Vaz, G., Le Loarer, F., Karanian, M., De Pinieux, G., Ducimetiere, F., Chemin, C., Morelle, M., Le Cesne, A., and Penel, N.

Published
2023
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26. Patient-reported outcomes and tolerability in patients receiving ripretinib versus sunitinib after treatment with imatinib in INTRIGUE, a phase 3, open-label study

Author

Gelderblom, Hans, Jones, Robin L., Blay, Jean-Yves, George, Suzanne, von Mehren, Margaret, Zalcberg, John R., Kang, Yoon-Koo, Razak, Albiruni Abdul, Trent, Jonathan, Attia, Steven, Le Cesne, Axel, Siontis, Brittany L., Goldstein, David, Boye, Kjetil, Sanchez, Cesar, Steeghs, Neeltje, Rutkowski, Piotr, Druta, Mihaela, Serrano, César, Somaiah, Neeta, Chi, Ping, Harrow, Brooke, Becker, Claus, Reichmann, William, Sherman, Matthew L., Ruiz-Soto, Rodrigo, Heinrich, Michael C., and Bauer, Sebastian

Published
2023
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27. Pembrolizumab in patients with rare and ultra-rare sarcomas (AcSé Pembrolizumab): analysis of a subgroup from a non-randomised, open-label, phase 2, basket trial

Author

Blay, Jean-Yves, Chevret, Sylvie, Le Cesne, Axel, Brahmi, Mehdi, Penel, Nicolas, Cousin, Sophie, Bertucci, Francois, Bompas, Emmanuelle, Ryckewaert, Thomas, Soibinet, Pauline, Boudou-Rouquette, Pascaline, Saada Bouzid, Esma, Soulie, Patrick, Valentin, Thibaud, Lotz, Jean-Pierre, Tosi, Diego, Neviere, Zoé, Cancel, Mathilde, Ray-Coquard, Isabelle, Gambotti, Laetitia, Legrand, Frédéric, Lamrani-Ghaouti, Assia, Simon, Clotilde, Even, Caroline, and Massard, Christophe

Published
2023
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28. Overview of the role of liquid biopsy in cancer management

Author

Tarek Assi, Rita Khoury, Rebecca Ibrahim, Maria Baz, Tony Ibrahim, and Axel LE Cesne

Subjects
DNA, Circulating tumor cells, Cancer, Molecular profiling, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

With the emergence of novel targeted therapeutic options in early-stage and advanced-stage malignancies, researchers have shifted their focus on developing personalized treatment plans through molecular profiling. Circulating tumor DNA (ctDNA) is a cell-free DNA (ctDNA) fragment, originating from tumor cells, and circulating in the bloodstream as well as biological fluids. Over the past decade, many techniques were developed for liquid biopsies through next-generation sequencing. This alternative non-invasive biopsy offers several advantages in various types of tumors over traditional tissue biopsy. The process of liquid biopsy is considered minimally invasive and therefore easily repeatable when needed, providing a more dynamic analysis of the tumor cells. Moreover, it has an advantage in patients with tumors that are not candidates for tissue sampling. Besides, it offers a deeper understanding of tumor burden as well as treatment response, thereby enhancing the detection of minimal residual disease and therapeutic guidance for personalized medicine. Despite its many advantages, ctDNA and liquid biopsy do have some limitations.This paper discusses the basis of ctDNA and the current data available on the subject, as well as its clinical utility. We also reflect on the limitations of using ctDNA in addition to its future perspectives in clinical oncology and precision medicine.

Published
2023
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33. Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC

Author

Pierre Kubicek, Axel Le Cesne, Cyril Lervat, Maud Toulmonde, Christine Chevreau, Florence Duffaud, Louis-Romée Le Nail, Magali Morelle, Nathalie Gaspar, Cécile Vérité, Marie-Pierre Castex, Nicolas Penel, Esma Saada, Sylvain Causeret, François Bertucci, Christophe Perrin, Emmanuelle Bompas, Daniel Orbach, Valérie Laurence, Sophie Piperno-Neumann, Philippe Anract, Maria Rios, Jean-Claude Gentet, Éric Mascard, Stéphanie Pannier, Pascale Blouin, Sébastien Carrère, Loïc Chaigneau, Pauline Soibinet-Oudot, Nadège Corradini, Pascaline Boudou-Rouquette, Jean-Christophe Ruzic, Valérie Lebrun-Ly, Pascale Dubray-Longeras, Sharmini Varatharajah, Céleste Lebbe, Mickaël Ropars, Jean-Emmanuel Kurtz, Cécile Guillemet, Jean-Pierre Lotz, Juliane Berchoud, Grégory Cherrier, Françoise Ducimetière, Claire Chemin, Antoine Italiano, Charles Honoré, Emmanuel Desandes, Jean-Yves Blay, François Gouin, and Perrine Marec-Bérard

Subjects
Adolescents and young adults, AYAs, Sarcoma, Management, Multidisciplinary tumor board, Reference centers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma at the national level. Patients and methods NETSARC database gathers regularly monitored and updated data from patients with sarcoma. NETSARC was queried for patients (15–30 years) with sarcoma diagnosed from 2010 to 2017 for whom tumor resection had been performed. We reported management, locoregional recurrence-free survival (LRFS), progression-free survival (PFS), and overall survival (OS) in AYA treated in French reference sarcoma centers (RSC) and outside RSC (non-RSC) and conducted multivariable survival analyses adjusted for classical prognostic factors. Results Among 3,227 patients aged 15–30 years with sarcoma diagnosed between 2010 and 2017, the study included 2,227 patients with surgery data available, among whom 1,290 AYAs had been operated in RSC, and 937 AYAs in non-RSC. Significant differences in compliance to guidelines were observed including pre-treatment biopsy (RSC: 85.9%; non-RSC 48.1%), pre-treatment imaging (RSC: 86.8%; non-RSC: 56.5%) and R0 margins (RSC 57.6%; non-RSC: 20.2%) (p

Published
2023
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36. Desmoid type fibromatosis in pediatric and young adults from French databases: Clinical characteristics and initial outcome according to age

Author

Bouttefroy, Séverine, Penel, Nicolas, Orbach, Daniel, Minard-Colin, Véronique, Le Cesne, Axel, Blay, Jean-Yves, Marec-Berard, Perrine, Verité, Cécile, Laurence, Valérie, Piperno-Neumann, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Chevreau, Christine, Duffaud, Florence, Salas, Sébastien, Morelle, Magali, Jean-Denis, Myriam, Italiano, Antoine, Bonvalot, Sylvie, and Corradini, Nadège

Published
2023
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37. CSPG4 expression in soft tissue sarcomas is associated with poor prognosis and low cytotoxic immune response

Author

Laurys Boudin, A de Nonneville, Pascal Finetti, Léna Mescam, A Le Cesne, Antoine Italiano, Jean-Yves Blay, Daniel Birnbaum, Emilie Mamessier, and François Bertucci

Subjects
Soft tissue sarcomas, CSPG4, Immune response, Immune therapy, Medicine
Abstract

Abstract Background Soft tissue sarcomas (STS) are heterogeneous and pro-metastatic tumors. Identification of accurate prognostic factors and novel therapeutic targets are crucial. CSPG4 is a cell surface proteoglycan with oncogenic functions. It recently emerged as a potential target for immunotherapy, including cell therapy based on CSPG4-specific chimeric antigen receptor (CAR)-redirected cytokine-induced killer lymphocytes (CSPG4-CAR.CIKs) in STS. However, expression of CSPG4 is poorly known in STS so far. Methods We analyzed CSPG4 gene expression in 1378 localized STS clinical samples, and searched for correlations with clinicopathological data, including disease-free survival (DFS), and with tumor immune features. Results CSPG4 expression was heterogeneous across samples. High expression was associated with younger patients’ age, more frequent undifferentiated pleomorphic sarcoma and myxofibrosarcoma pathological subtypes, more frequent internal trunk tumor site, and more CINSARC high-risk samples. No correlation existed with pathological tumor size and grade, and tumor depth. Patients with high CSPG4 expression displayed 49% (95% CI 42–57) 5-year DFS versus 61% (95% CI 56–68) in patients with low expression (p = 3.17E−03), representing a 49% increased risk of event in the “CSPG4-high” group (HR = 1.49, 95% CI 1.14–1.94). This unfavorable prognostic value persisted in multivariate analysis, independently from other variables. There were significant differences in immune variables between “CSPG4-high” and “CSPG4-low” tumors. The "CSPG4-low" tumors displayed profiles suggesting higher anti-tumor cytotoxic immune response and higher potential vulnerability to immune checkpoint inhibitors (ICI). By contrast, the "CSPG4-high" tumors displayed profiles implying an immune-excluded tumor microenvironment, potentially induced by hypoxia, resulting from an immature chaotic microvasculature, and/or the presence of contractile myofibroblasts. Conclusions Patients with “CSPG4-high” STS, theoretically candidate for CAR.CIKs, display shorter DFS and an immune environment unfavorable to vulnerability to CAR.CIKs, which could be improved by combining anti-angiogenic drugs able to normalize the tumor vasculature. By contrast, “CSPG4-low” STS are better candidates for immune therapy involving ICI.

Published
2022
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38. Coframalaxius bletteryi gen. et sp. nov. from subterranean habitat in Southern France (Hemiptera, Fulgoromorpha, Cixiidae, Oecleini)

Author

Maxime Le Cesne, Thierry Bourgoin, Hannelore Hoch, Yang Luo, and Yalin Zhang

Subjects
Biology (General), QH301-705.5
Abstract

A new planthoppers genus and species of Cixiidae Oecleini, Coframalaxius bletteryi gen. et sp. nov. newly discovered in a cave near Nice in southern France, is described. Molecular analysis confirms the morphology-based classification of Coframalaxius as sister to Trigonocranus within the Oecleni. Several morphological characters are further discussed. A double-grasping coxo-femoral and femoro-tibial system is regarded as apomorphic for the oecline taxa and would allow the nymph to firmly grab the roots and rootlets on which it feeds or use to progress in the soil. Wing vein patterns are discussed in the Cixiidae: 1) for the forewings, Oecleini belong to the trifid type of the anterior MP branch, leading to the reinterpretation of some recently described Neotropical species, 2) for the hindwing, four connection types (U-, V-, Y- and I-types) between MP and CuA are described. Oecleini belongs to I-type with a complete fusion of MP3+4 with CuA1. Although the area where the cave is located is well-studied with respect to its regularly sampled epigean fauna for many years, the taxon is new to science, highlighting its probable completely hypogean life cycle and leading to consider Coframalaxius bletteryi as an eutroglophile species.

Published
2022
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40. Long-term follow-up of nilotinib in patients with advanced tenosynovial giant cell tumours: Long-term follow-up of nilotinib in TGCT

Author

Spierenburg, Geert, Grimison, Peter, Chevreau, Christine, Stacchiotti, Silvia, Piperno-Neumann, Sophie, Le Cesne, Axel, Ferraresi, Virginia, Italiano, Antoine, Duffaud, Florence, Penel, Nicolas, Metzger, Severine, Chabaud, Sylvie, van der Heijden, Lizz, Pérol, David, van de Sande, Michiel A.J., Blay, Jean-Yves, and Gelderblom, Hans

Published
2022
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41. Systemic treatment in advanced phyllodes tumor of the breast: a multi-institutional European retrospective case-series analyses

Author

Palassini, E., Mir, O., Grignani, G., Vincenzi, B., Gelderblom, H., Sebio, A., Valverde, C., Baldi, G. G., Brunello, A., Cardellino, G. G., Marrari, A., Badalamenti, G., Martin-Broto, J., Ferraresi, V., Libertini, M., Turano, S., Gataa, I., Collini, P., Tos, A. P. Dei, Gennaro, M., Bini, F., Provenzano, S., Vullo, S. Lo, Mariani, L., Le Cesne, A., and Casali, P. G.

Published
2022
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44. Patterns of care and outcomes of 417 patients with METAstatic SYNovial sarcoma (METASYN): real-life data from the French Sarcoma Group (FSG)

Author

Moreau-Bachelard, C., Campion, L., Toulmonde, M., Le Cesne, A., Brahmi, M., Italiano, A., Mir, O., Piperno-Neumann, S., Laurence, V., Firmin, N., Penel, N., Duffaud, F., Chevreau, C., Bertucci, F., Narciso, B., Dubray-Longeras, P., Delcambre, C., Saada-Bouzid, E., Boudou-Rouquette, P., Soulie, P., Perrin, C., Blay, J.Y., and Bompas, E.

Published
2022
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46. Desmoid type fibromatosis in pediatric and young adults from French databases: Clinical characteristics and initial outcome according to age

Author

Séverine Bouttefroy, Nicolas Penel, Daniel Orbach, Véronique Minard-Colin, Axel Le Cesne, Jean-Yves Blay, Perrine Marec-Berard, Cécile Verité, Valérie Laurence, Sophie Piperno-Neumann, Anne-Sophie Defachelles, Emmanuelle Bompas, Christine Chevreau, Florence Duffaud, Sébastien Salas, Magali Morelle, Myriam Jean-Denis, Antoine Italiano, Sylvie Bonvalot, and Nadège Corradini

Subjects
Desmoid-type fibromatosis, Children, Adolescent, Young adults, Active surveillance, Registry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Desmoid type fibromatosis (DTF) are rare intermediate malignancies with unpredictable outcome. Series containing children and young adults (YA) are lacking. Methods: The aim of this retrospective study was to describe the French population of patients

Published
2023
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47. Medium levels of transcription and replication related chromosomal instability are associated with poor clinical outcome

Author

Ataaillah Benhaddou, Laetitia Gaston, Gaëlle Pérot, Nelly Desplat, Laura Leroy, Sophie Le Guellec, Mohamed Ben Haddou, Philippe Rochaix, Thibaud Valentin, Gwenaël Ferron, Christine Chevreau, Binh Bui, Eberhard Stoeckle, Axel Le Cesne, Sophie Piperno-Neumann, Françoise Collin, Nelly Firmin, Gonzague De Pinieux, Jean-Michel Coindre, Jean-Yves Blay, and Frédéric Chibon

Subjects
Medicine, Science
Abstract

Abstract Genomic instability (GI) influences treatment efficacy and resistance, and an accurate measure of it is lacking. Current measures of GI are based on counts of specific structural variation (SV) and mutational signatures. Here, we present a holistic approach to measuring GI based on the quantification of the steady-state equilibrium between DNA damage and repair as assessed by the residual breakpoints (BP) remaining after repair, irrespective of SV type. We use the notion of Hscore, a BP “hotspotness” magnitude scale, to measure the propensity of genomic structural or functional DNA elements to break more than expected by chance. We then derived new measures of transcription- and replication-associated GI that we call iTRAC (transcription-associated chromosomal instability index) and iRACIN (replication-associated chromosomal instability index). We show that iTRAC and iRACIN are predictive of metastatic relapse in Leiomyosarcoma (LMS) and that they may be combined to form a new classifier called MAGIC (mixed transcription- and replication-associated genomic instability classifier). MAGIC outperforms the gold standards FNCLCC and CINSARC in stratifying metastatic risk in LMS. Furthermore, iTRAC stratifies chemotherapeutic response in LMS. We finally show that this approach is applicable to other cancers.

Published
2021
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50. A randomized phase III trial comparing trabectedin to best supportive care in patients with pre-treated soft tissue sarcoma: T-SAR, a French Sarcoma Group trial

Author

Le Cesne, A., Blay, J.-Y., Cupissol, D., Italiano, A., Delcambre, C., Penel, N., Isambert, N., Chevreau, C., Bompas, E., Bertucci, F., Chaigneau, L., Piperno-Neumann, S., Salas, S., Rios, M., Guillemet, C., Bay, J.-O., Ray-Coquard, I., Haddag, L., Bonastre, J., Kapso, R., Fraslin, A., Bouvet, N., Mir, O., and Foulon, S.

Published
2021
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