Search

Your search keyword '"Lambert, Gavin W."' showing total 522 results
Start Over Author "Lambert, Gavin W." Publication Type Academic Journals
522 results on '"Lambert, Gavin W."'

17. Long-Term Blood Pressure Reductions Following Catheter-Based Renal Denervation: A Systematic Review and Meta-Analysis.

Author

Sesa-Ashton, Gianni, Nolde, Janis M., Muente, Ida, Carnagarin, Revathy, Macefield, Vaughan G., Dawood, Tye, Lambert, Elisabeth A., Lambert, Gavin W., Walton, Antony, Esler, Murray D., and Schlaich, Markus P.

Abstract

BACKGROUND: Renal denervation is a recognized adjunct therapy for hypertension with clinically significant blood pressure (BP)-lowering effects. Long-term follow-up data are critical to ascertain durability of the effect and safety. Aside from the 36-month follow-up data available from randomized control trials, recent cohort analyses extended follow-up out to 10 years. We sought to analyze study-level data and quantify the ambulatory BP reduction of renal denervation across contemporary randomized sham-controlled trials and available long-term follow-up data up to 10 years from observational studies. METHODS: A systematic review was performed with data from 4 observational studies with follow-up out to 10 years and 2 randomized controlled trials meeting search and inclusion criteria with follow-up data out to 36 months. Study-level data were extracted and compared statistically. RESULTS: In 2 contemporary randomized controlled trials with 36-month follow-up, an average sham-adjusted ambulatory systolic BP reduction of −12.7±4.5 mm Hg from baseline was observed (P =0.05). Likewise, a −14.8±3.4 mm Hg ambulatory systolic BP reduction was found across observational studies with a mean long-term follow-up of 7.7±2.8 years (range, 3.5–9.4 years; P =0.0051). The observed reduction in estimated glomerular filtration rate across the long-term follow-up was in line with the predicted age-related decline. Antihypertensive drug burden was similar at baseline and follow-up. CONCLUSIONS: Renal denervation is associated with a significant and clinically meaningful reduction in ambulatory systolic BP in both contemporary randomized sham-controlled trials up to 36 months and observational cohort studies up to 10 years without adverse consequences on renal function. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

21. Deficiency of Prebiotic Fibre and Insufficient Signalling Through Gut Metabolite Sensing Receptors Leads to Cardiovascular Disease

Author

Kaye, David M., Shihata, Waled, Jama, Hamdi A., Tsyganov, Kirill, Ziemann, Mark, Kiriazis, Helen, Horlock, Duncan, Vijay, Amrita, Giam, Beverly, Vinh, Antony, Johnson, Chad, Fiedler, April, Donner, Daniel, Snelson, Matthew, Coughlan, Melinda T., Phillips, Sarah, Du, Xiao-Jun, El-Osta, Assam, Drummond, Grant, Lambert, Gavin W, Spector, Tim, Valdes, Ana M., Mackay, Charles R., and Marques, Francine Z.

Published
2020
Full Text
View/download PDF

32. Trends in blood pressure changes and hypertension prevalence in Australian adults before and during the COVID‐19 pandemic.

Author

Nolde, Janis M., Streets, Fleur, Meyer, Denny, Chen, Won Sun, Wei, Jiajun, Wickramasinghe, Nilmini, Hannebery, Patrick, Lambert, Gavin W., and Schlaich, Markus P.

Abstract

Efforts to limit the impact of the coronavirus disease (COVID‐19) pandemic led to the implementation of public health measures and reallocation of health resources. To investigate trends in blood pressure (BP), hypertension and BMI in the Australian population during the COVID‐19 pandemic, data from publicly accessible health stations were analyzed. Average BP and BMI measured by the SiSU Health Station network in Australia in over 1.6 million health screenings were compared between the years 2018 and 2021. Additionally, paired trajectories for BP and BMI development before and during the COVID‐19 pandemic were calculated. Comparisons between pre‐COVID years and post‐COVID years of 2018 versus 2020, 2019 versus 2020, 2018 versus 2021, and 2019 versus 2021 showed increases in average adjusted systolic BP of 2.0, 1.7, 2.6, and 2.3 mmHg, respectively. Paired analysis of longitudinal data showed an overall increase in the trajectory of systolic BP of 3.2 mmHg between pre‐ and post‐COVID years. The prevalence of hypertension in users of the health stations increased by approximately 25% in the years 2020–2021. Similar trends were seen for BMI. Data from public Australian health stations indicated a strong trend toward higher BP during the COVID‐19 pandemic. At the population level, BP increments have been shown to markedly increase cardiovascular disease risk. Anti‐pandemic measures need to be carefully evaluated in terms of secondary public health effects and health support systems extended to effectively target cardiovascular risk. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

34. Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans

Author

Loh, Rebecca K. C., Formosa, Melissa F., Eikelis, Nina, Bertovic, David A., Anderson, Mitchell J., Barwood, Shane A., Nanayakkara, Shane, Cohen, Neale D., La Gerche, Andre, Reutens, Anne T., Yap, Kenneth S., Barber, Thomas W., Lambert, Gavin W., Cherk, Martin H., Duffy, Stephen J., Kingwell, Bronwyn A., and Carey, Andrew L.

Published
2017
Full Text
View/download PDF

45. Renal Denervation Reduces Monocyte Activation and Monocyte–Platelet Aggregate Formation: An Anti-Inflammatory Effect Relevant for Cardiovascular Risk

Author

Zaldivia, Maria T.K., Rivera, Jennifer, Hering, Dagmara, Marusic, Petra, Sata, Yusuke, Lim, Bock, Eikelis, Nina, Lee, Rebecca, Lambert, Gavin W., Esler, Murray D., Htun, Nay M., Duval, Jacqueline, Hammond, Louise, Eisenhardt, Steffen U., Flierl, Ulrike, Schlaich, Markus P., and Peter, Karlheinz

Published
2017
Full Text
View/download PDF

46. Catheter-Based Renal Denervation: 9-Year Follow-Up Data on Safety and Blood Pressure Reduction in Patients With Resistant Hypertension.

Author

Sesa-Ashton, Gianni, Nolde, Janis M., Muente, Ida, Carnagarin, Revathy, Lee, Rebecca, Macefield, Vaughan G., Dawood, Tye, Sata, Yusuke, Lambert, Elisabeth A., Lambert, Gavin W., Walton, Antony, Kiuchi, Marcio G., Esler, Murray D., and Schlaich, Markus P.

Abstract

Background: Recent sham-controlled randomized clinical trials have confirmed the safety and efficacy of catheter-based renal denervation (RDN). Long-term safety and efficacy data beyond 3 years are scarce. Here, we report on outcomes after RDN in a cohort of patients with resistant hypertension with an average of ≈9-year follow-up (FU). Methods: We recruited patients with resistant hypertension who were previously enrolled in various RDN trials applying radiofrequency energy for blood pressure (BP) lowering. All participants had baseline assessments before RDN and repeat assessment at long-term FU including medical history, automated office and ambulatory BP measurement, and routine blood and urine tests. We analyzed changes between baseline and long-term FU. Results: A total of 66 participants (mean±SD, 70.0±10.3 years; 76.3% men) completed long-term FU investigations with a mean of 8.8±1.2 years post-procedure. Compared with baseline, ambulatory systolic BP was reduced by −12.1±21.6 (from 145.2 to 133.1) mm Hg (P <0.0001) and diastolic BP by −8.8±12.8 (from 81.2 to 72.7) mm Hg (P <0.0001). Mean heart rate remained unchanged. At long-term FU, participants were on one less antihypertensive medication compared with baseline (P =0.0052). Renal function assessed by estimated glomerular filtration rate fell within the expected age-associated rate of decline from 71.1 to 61.2 mL/min per 1.73 m2. Time above target was reduced significantly from 75.0±25.9% at baseline to 47.3±30.3% at long-term FU (P <0.0001). Conclusions: RDN results in a significant and robust reduction in both office and ambulatory systolic and diastolic BP at ≈9-year FU after catheter-based RDN on less medication and without evidence of adverse consequences on renal function. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

48. Stress and social isolation, and its relationship to cardiovascular risk in young adults with intellectual disability.

Author

Zwack, Clara C., McDonald, Rachael, Tursunalieva, Ainura, Vasan, Shradha, Lambert, Gavin W., and Lambert, Elisabeth A.

Subjects
CARDIOVASCULAR diseases risk factors, OBESITY, PREDICTIVE tests, MULTIPLE regression analysis, EFFECT sizes (Statistics), SOCIAL isolation, ARTERIAL diseases, SURVEYS, PATIENT monitoring, RESEARCH funding, DESCRIPTIVE statistics, DATA analysis software, PSYCHOLOGICAL stress, INTELLECTUAL disabilities
Abstract

Stress produces many physiological changes, some of which may contribute to the development of cardiovascular disease (CVD). Individuals with intellectual disability (ID) are exposed to multiple and stressful challenges everyday which may put them at increased cardiovascular risk. This current study aimed to establish whether adults with ID experience higher levels of subjective stress and encounter different stressors (including social isolation) than the general population, and whether there is a relationship between stress and cardiometabolic profile in this population. Adults with ID (n = 35) aged 18–45 years completed the Subjective Stress Survey, and underwent a physiological assessment to measure blood pressure, metabolic profile and subclinical CVD risk factors, and were compared to a control group (n = 29). Multiple regression was used to investigate whether cardiometabolic parameters were predicative of SSS scores. Findings showed adults with ID have higher perceived stress levels (total score ID: 21.3 ± 11.4 vs control: 13.9 ± 9.0, p = 0.006), which is elicited by unique stressors, when compared to people without ID. Stress was strongly associated with increased social isolation (r = −0.38, p = 0.002) and with obesity in females with mild ID (r = 0.72). Regression showed that arterial stiffness was predictive of total SSS score (p = 0.038). Adults with ID aged 18–45 years report higher levels of perceived stress when compared to people without ID. Reducing stress in this young population may prevent development of arterial stiffness, and consequently lower the risk of cardiometabolic morbidity and mortality. There are unique targets for stress management in young adults with intellectual disability, including supporting decision-making and improving self-efficacy. Improving community integration and reducing social isolation may decrease perceived stress in young adults with intellectual disability. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

50. Correction to: Pioglitazone reduces cold-induced brown fat glucose uptake despite induction of browning in cultured human adipocytes: a randomised, controlled trial in humans

Author

Loh, Rebecca K. C., Formosa, Melissa F., Eikelis, Nina, Bertovic, David A., Anderson, Mitchell J., Barwood, Shane A., Nanayakkara, Shane, Cohen, Neale D., La Gerche, Andre, Reutens, Anne T., Yap, Kenneth S., Barber, Thomas W., Lambert, Gavin W., Cherk, Martin H., Duffy, Stephen J., Kingwell, Bronwyn A., and Carey, Andrew L.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results