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O objetivo foi comparar o comportamento da lactacidemia e parâmetros gasométricos em exercícios resistidos utilizando uma técnica pouco invasiva Abbott i-STAT Portable Clinical Analyser. 10 homens, 20,3 ± 4,2 anos, 74 ± 10,2Kg, 177 ± 4,6cm e 23,8 ± 3,2 Kg/m2 realizaram uma sessão cada de leg press (LP) e supino reto (SR) (4 X 10 a 70% de 1RM com 3’). Os valores elevaram-se da 1ª série a pós-esforço em Borg e Omni e do repouso a pós-esforço em lactato e paO2. E reduziram do repouso a pós-esforço pH; paCO2; HCO3- e BE (P

Abstract Aims: This study aimed to evaluate the kinetics of lactate and lactate dehydrogenase B (LDH-B) protein levels as well as the maximum effort capacity of spontaneously hypertensive rats (SHRs) with experimental acute myocardial infarction (AMI). Methods: thirty-two SHRs were divided into (n=8/group): S (sham), SE (sham+exercise), I (AMI), and IE (AMI+exercise). A maximum exercise test (treadmill) was evaluated before AMI or sham surgery. Echocardiography was performed 48h after the surgery. Lactacidemia was assessed at rest and during an intense exercise bout (48h after echocardiography). A two-way ANOVA followed by the post-hoc (Bonferroni) test was used, p

En el presente trabajo se estudió la posible asociación entre la temperatura corporal, glucemia y lactacidemia con el acto quirúrgico de esterilización de caninos machos y hembras. Estos parámetros fueron elegidos ya que se sabe que sufren modificaciones ante eventos estresantes(1) y es de esperar que dichos cambios se produzcan como consecuencia del acto quirúrgico. Se estudiaron las variables de interés en tres tiempos a lo largo del proceso quirúrgico en caninos macho y hembra. Los resultados demostraron disminuciones significativas del lactato y la temperatura rectal y un aumento significativo de la glucemia

O objetivo do presente estudo foi verificar a influência na alternância na ordem de execução de exercícios para membros inferiores: Agachamento Livre (AGL) e cadeira extensora (CE) sobre a lactacidemia, escala de percepção de esforço de OMNI e parâmetros cardiovasculares. 10 voluntários, 27,3±1,7anos; 177,3±2,4cm; 87,5 ± 4,1kg realizaram duas sequencias de 3 séries de 10 repetições a 70% 1RM de agachamento livre (AGL) e cadeira extensora (CE) alternando os exercícios. A 1a sequência AGL e CE e a 2a sequencia CE e AGL. Foram aferidas em repouso e ao final de cada série: lactacidemia, percepção subjetiva de esforço por OMNI, frequência cardíaca, pressão arterial sistólica, pressão arterial diastólica e duplo produto. Todos os parâmetros estudados apresentaram significativas elevações na 2a sequencia quando comparado a 1a sequência. Concluímos, portanto que a realização de uma sequência de exercício resistido iniciando com recrutamento de pequenos grupamentos musculares anterior a grandes grupamentos induz em significativo estresse sobre o sistema metabólico (lactacidemia), esforço percebido (escala de percepção de esforço de OMNI) e sistema cardiovascular (FC, PAS, PAD e DP). Assim sendo, a normativa do American College of Sports Medicine que sugere treinamento de grandes grupamentos anterior a pequenos seja adequada, podemos sugerir que a alternância acarretaria um estresse, sobrecarga e fadiga maiores, talvez seja o objetivo de alguns programas de treinamento resistido com o intuito de hipertrofia muscular. ABSTRACT The effect of alternation in the exercises of large and small groupings in lower limbs on lactacidemia and cardiovascular parameters The aim of this study was to investigate the influence of alternating the exercises execution order for legs: Squat Free (AGL) and extensor chair (EC) on the lactacidemia, perception scale of OMNI effort and cardiovascular parameters. 10 volunteers 27.3 ± 1.7 anos; 177.3 ± 2.4cm; 87.5 ± 4.1kg were two sequences of 3 sets of 10 repetitions at 70% 1RM squat free (SF) and leg extension (LE) alternating exercises. The first sequence SF and EC and the second sequence LE and SF. They were measured at rest and after each series: lactacidemia, perceived exertion by OMNI, heart rate, systolic blood pressure, diastolic blood pressure and double product. All parameters studied showed significant increases in the second sequence when compared to the first sequence. We therefore conclude that performing a sequence resistance exercise starting with recruitment of small anterior muscle groups to large groups induces a significant stress on the metabolic system (lactacidemia), perceived exertion (scale of perceived OMNI effort) and cardiovascular system ( HR, SBP, DBP and DP). Therefore, the rules of the American College of Sports Medicine suggests training large previous groups small is adequate, we suggest that the alternation would have carried a stress overload and increased fatigue, it may be the objective of some resistance training programs in order muscle hypertrophy.

In horse pathology, colic syndrome, through its etiopathogenetic complexity, diversity of clinical expression and incidence, is a dominant one, whose research of inductive, clinical-evolutionary aspects and paraclinical changes requires a concentrated multidisciplinary and correlatively-analytically evaluated approach, in order to optimize the success of its therapy. The aim of this study is to evaluate the level of blood lactic acid in patients and its use as a diagnostic tool in terms of clinical evolution. [ABSTRACT FROM AUTHOR]

The authors discuss about the relationships between oculoauriculo- vertebral spectrum (OAVS), a malformative condition affecting eyes, ears and vertebral structures mainly derived from neural crests, and autosomal dominant progressive external ophthalmoplegia (adPEO) – an electron transport chain disorder characterized by palpebral ptosis and muscular symptoms – on the basis of laboratory data and clinical signs in a case belonging to a family in which symptoms of both diseases occur. Hemifacial microsomia and ears abnormalities were the main neural crest cells (NCC) derived signs for OAVS diagnosis. Palpebral ptosis and the associated hyperlactacidemia with high Lactate to Pyruvate ratio were main signs for the suspicion of adPEO, but the diagnosis was proposed by clinical, biochemical, electrophysiological and genetic methods because the biopsy not always is diagnostic, as in our case. The association of two groups of symptoms (malformed, NCCrelated, and myopatic-electron transport related) in the same subject as observed in our case and partially in the family, may be ascribed to nuclear abnormalities and mitochondrial electron transport disorder, respectively, as well as to a possible common etiopathogenetic mechanism. In some cases of OAVS, the malformations may be consequent to oxidative phosphorilation disease (OXPHOS) derangement, as previously demonstrated; the extensive determination of lactacidemia may be important to address the research on OAVS patients in the mitochondrial/OXPHOS genetic domain, with advantage in the knowledge of OAVS pathogenesis.

The authors discuss about the relationships between oculoauriculo- vertebral spectrum (OAVS), a malformative condition affecting eyes, ears and vertebral structures mainly derived from neural crests, and autosomal dominant progressive external ophthalmoplegia (adPEO) - an electron transport chain disorder characterized by palpebral ptosis and muscular symptoms - on the basis of laboratory data and clinical signs in a case belonging to a family in which symptoms of both diseases occur. Hemifacial microsomia and ears abnormalities were the main neural crest cells (NCC) derived signs for OAVS diagnosis. Palpebral ptosis and the associated hyperlactacidemia with high Lactate to Pyruvate ratio were main signs for the suspicion of adPEO, but the diagnosis was proposed by clinical, biochemical, electrophysiological and genetic methods because the biopsy not always is diagnostic, as in our case. The association of two groups of symptoms (malformed, NCCrelated, and myopatic-electron transport related) in the same subject as observed in our case and partially in the family, may be ascribed to nuclear abnormalities and mitochondrial electron transport disorder, respectively, as well as to a possible common etiopathogenetic mechanism. In some cases of OAVS, the malformations may be consequent to oxidative phosphorilation disease (OXPHOS) derangement, as previously demonstrated; the extensive determination of lactacidemia may be important to address the research on OAVS patients in the mitochondrial/OXPHOS genetic domain, with advantage in the knowledge of OAVS pathogenesis. [ABSTRACT FROM AUTHOR]

In the present paper the possible association between body temperature, glycemia and lacticaemia with the surgical act of sterilization of male and female canines is studied. These variables were chosen since they are known to be modified in the face of stressful events. It is expect d to observed changes in metabolic substrates used by the patient during surgery. The variables of interest were studied in three times (pre and intra-surgical) in male and female canines. Significant decreases in lactate and rectal temperature and a significant increase in blood glucose were detected. [ABSTRACT FROM AUTHOR]

The purposes of this study were to assess the influence of stage selection from the incremental phase and the use of peak lactate after hyperlactatemia induction on the determination of the lactate minimum intensity (iLACmin). Twelve moderately active university students (23±5 years, 78.3±14.1 kg, 175.3±5.1 cm) performed a maximal incremental test to determine the respiratory compensation point (RCP) (initial intensity at 70 W and increments of 17.5 W every 2 minutes) and a lactate minimum test (induction with the Wingate test, the incremental test started at 30 W below RCP with increments of 10 W every 3 minutes) on a cycle ergometer. The iLACmin was determined using second order polynomial adjustment applying five exercise stage selection: 1) using all stages (iLACmin P); 2) using all stages below and two stages above iLACminP (iLACminA); 3) using two stages below and all stages above iLACminP (iLACminB); 4) using the largest and same possible number of stages below and above the iLACminP (iLACminI); 5) using all stages and peak lactate after hyperlactatemia induction (iLACminD). No differences were found between the iLACminP (138.2±30.2 W), iLACminA (139.1±29.1 W), iLACminB (135.3±14.2 W), iLACminI (138.6±20.5 W) and iLACmiD (136.7±28.5 W) protocols, and a high level of agreement between these intensities and iLACminP was observed. Oxygen uptake, heart rate, rating of perceived exertion and lactate corresponding to these intensities was not different and was strongly correlated. However, the iLACminB presented the lowest success rate (66.7%). In conclusion, stage selection did not influence the determination of iLACmin but modified the success rate

Copyright of Brazilian Journal of Kineanthropometry & Human Performance is the property of Brazilian Journal of Kineanthropometry & Human Performance and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The presence of anaerobic threshold (AT) in resistance exercise has been studied in recent years. The aim of this study was to identify and to compare the AT in elderly population during leg press (LP) and bench press (BP). Fourteen elderly men (68.9 ± 4.0 years, 170.5 ± 0.05 cm e 76.1 ± 7.8 kg) performed two maximal incremental tests based on percentages of one repetition maximum (1RM) for the determination of AT during LP and BP. Blood lactate, heart rate (HR) and rating of perceived exertion (RPE) were measured at the final of each stage and it were compared between the exercises at the intensity of the AT. The level of significance was p ≤ .05. The AT in the LP was 27.9 ± 5.0% of 1RM and in the BP was 21.5 ± 3.1% of 1RM, with statistical differences between the exercises. However, blood lactate was significantly lower on LP (1.36 ± 0.40 mmol.L-1) when compared with BP (1.92 ± 0.38 mmol.L-1). Although the intensity of AT has been different between the exercises, HR and RPE did not presented statistical significant differences. It was possible to identify the AT on elderly population during LP and BP exercises and it occurred in lower intensities for BP. [ABSTRACT FROM AUTHOR]

Abstract Background: Lactacidemia is often seen under stress conditions including septic shock in the newborn. Under stress conditions, plasma catecholamine concentrations are increased and play an important role in lactate metabolism. Our previous study shows that perinatal feeding of omega-3 polyunsaturated fatty acid enriched diet (ω-3PUFA) attenuates lactacidemia of endotoxic shock in 10-day-old rats. In the omega-6 fatty acids series, decosapentanoic acid, two series prostaglandins and four series leukotrienes are synthesized through linoleic acids. As plasma lactate concentration correlates with the outcome of septic shock in the newborn, it is important to understand the effects of ω-3PUFA on lactate metabolism. Thus, we tested the hypothesis that perinatal feeding of omega-3 polyunsaturated fatty acid enriched diet (ω-3PUFA) alters responses to catecholamines and attenuates the stress-induced lactacidemia in 10-day-old rats. Methods: Ten-day-old rats which perinatally fed ω-3PUFA. Lactacidemia was induced by swimming for 5 min. Ten-day-old rats which perinatally fed ω-6PUFA were controls. Omega-6 fatty acids series are contained in animal fats and corn oil. Adrenergic blockers were used to assess roles of catecholamines in swimming-induced lactacidemia. Results: Swimming increased plasma lactate concentration less (P<0.05) in rats fed ω-3PUFA than rats fed ω-6PUFA. Swimming increased plasma concentrations of glucose and glucagon, cyclic adenosine monophosphate (cAMP) concentration and phosphoenolypruvate carboxykinase mRNA in the liver, and cAMP concentration in the hindlimb muscle more (P<0.05) in rats fed ω-3PUFA than in rats fed ω-6PUFA. Phentolamine and propranolol enhanced swim-induced lactacidemia in the ω-3PUFA group, while they decreased the lactacidemia in the ω-6PUFA group. Propranolol enhanced swimming-induced hyperglycemia in the ω-6PUFA group more than in the ω-3PUFA group. Conclusions: ω-3PUFA might increase β-adrenergic response in the liver and increase gluconeogenesis in response to stress, resulting in decreased lactacidemia. [ABSTRACT FROM AUTHOR]

The role of the liver in the changes of acid-base balance and plasma lipids in surface-induced deep hypothermia for open-heart surgery was investigated clinically and experimentally. The metabolic acidosis generally observed in open-heart surgery under surface-induced deep hypothermia is derived from lactacidemia. Although the accelerated anaerobic glycolysis is partly responsible, the depressed acidic metabolite-disposing ability of the liver also plays an important role. The evidence which is presented to show the decrease of plasma lipids other than NEFA under hypothermia is probably due to the hepatic accumulation of lipids and the decreased lipids release from the liver. [ABSTRACT FROM AUTHOR]

Metabolic acidosis observed in open heart surgery under surface induced deep hypothermia is due to lactacidemia, but is reversible, returning to precooling level 24 hours after the operation, and it can be considered more or less as a pathognomonic finding. Although the correction of acidosis present did not influence the level of lactic acid in blood, it was found to be clinically advantageous during the heartresuscitation. Therefore, it is advisable to maintain acid-base balance within-10 mEq per 1 of base excess. [ABSTRACT FROM AUTHOR]

Copyright of Langenbecks Archiv fuer Chirurgie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In comparison to control rats, basal plasma corticosterone level and lactacidemia significantly increased in rats submitted to a bilateral lesion of the lateral olfactory tract and/or the anterior branch of the anterior commissure. Only the anterior branch of the anterior commissure induced hyperglycemia; that of the lateral olfactory tract exerted an opposite effect. [ABSTRACT FROM AUTHOR]

Copyright of Actualités Pharmaceutiques is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)