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Your search keyword '"Kryscio, Richard J."' showing total 624 results
Start Over Author "Kryscio, Richard J." Publication Type Academic Journals
624 results on '"Kryscio, Richard J."'

4. Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI

Author

Ding, Xiuhua, Charnigo, Richard J, Schmitt, Frederick A, Kryscio, Richard J, Abner, Erin L, and Initiative, for the Alzheimer’s Disease Neuroimaging

Subjects
Clinical and Health Psychology, Health Sciences, Psychology, Alzheimer's Disease, Behavioral and Social Science, Aging, Clinical Research, Acquired Cognitive Impairment, Dementia, Brain Disorders, Neurodegenerative, Neurosciences, Prevention, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Mental health, Neurological, Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Cognitive Dysfunction, Disease Progression, Female, Humans, Longitudinal Studies, Male, Memory and Learning Tests, Memory, Episodic, Middle Aged, Models, Psychological, Models, Statistical, Prognosis, Risk Factors, Alzheimer’s Disease Neuroimaging Initiative, General Science & Technology
Abstract

BackgroundMemory assessment is a key factor for the diagnosis of cognitive impairment. However, memory performance over time may be quite heterogeneous within diagnostic groups.MethodTo identify latent trajectories in memory performance and their associated risk factors, we analyzed data from Alzheimer's Disease Neuroimaging Initiative (ADNI) participants who were classified either as cognitively normal or as Mild Cognitive Impairment (MCI) at baseline and were administered the Rey Auditory Verbal Learning test (RAVLT) for up to 9 years. Group-based trajectory modeling on the 30-minute RAVLT delayed recall score was applied separately to the two baseline diagnostic groups.ResultsThere were 219 normal subjects with mean age 75.9 (range from 59.9 to 89.6) and 52.5% male participants, and 372 MCI subjects with mean age 74.8 (range from 55.1 to 89.3) and 63.7% male participants included in the analysis. For normal subjects, six trajectories were identified. Trajectories were classified into three types, determined by the shape, each of which may comprise more than one trajectory: stable (~30% of subjects), curvilinear decline (~ 28%), and linear decline (~ 42%). Notably, none of the normal subjects assigned to the stable stratum progressed to dementia during the study period. In contrast, all trajectories identified for the MCI group tended to decline, although some participants were later re-diagnosed with normal cognition. Age, sex, and education were significantly associated with trajectory membership for both diagnostic groups, while APOE ɛ4 was only significantly associated with trajectories among MCI participants.ConclusionMemory trajectory is a strong indicator of dementia risk. If likely trajectory of memory performance can be identified early, such work may allow clinicians to monitor or predict progression of individual patient cognition. This work also shows the importance of longitudinal cognitive testing and monitoring.

Published
2019

9. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology

Author

Nelson, Peter T, Estus, Steven, Abner, Erin L, Parikh, Ishita, Malik, Manasi, Neltner, Janna H, Ighodaro, Eseosa, Wang, Wang-Xia, Wilfred, Bernard R, Wang, Li-San, Kukull, Walter A, Nandakumar, Kannabiran, Farman, Mark L, Poon, Wayne W, Corrada, Maria M, Kawas, Claudia H, Cribbs, David H, Bennett, David A, Schneider, Julie A, Larson, Eric B, Crane, Paul K, Valladares, Otto, Schmitt, Frederick A, Kryscio, Richard J, Jicha, Gregory A, Smith, Charles D, Scheff, Stephen W, Sonnen, Joshua A, Haines, Jonathan L, Pericak-Vance, Margaret A, Mayeux, Richard, Farrer, Lindsay A, Van Eldik, Linda J, Horbinski, Craig, Green, Robert C, Gearing, Marla, Poon, Leonard W, Kramer, Patricia L, Woltjer, Randall L, Montine, Thomas J, Partch, Amanda B, Rajic, Alexander J, Richmire, KatieRose, Monsell, Sarah E, Alzheimer’ Disease Genetic Consortium, Schellenberg, Gerard D, and Fardo, David W

Subjects
Biomedical and Clinical Sciences, Neurosciences, Neurodegenerative, Aging, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Genetics, Alzheimer's Disease, Dementia, Human Genome, Prevention, Acquired Cognitive Impairment, 2.1 Biological and endogenous factors, Neurological, Good Health and Well Being, Aged, 80 and over, Cohort Studies, Databases as Topic, Endophenotypes, Genome-Wide Association Study, Hippocampus, Humans, Polymorphism, Single Nucleotide, Sclerosis, Sulfonylurea Compounds, Sulfonylurea Receptors, Oldest old, Neuropathology, KATP, CTAGE5, ADGC, Potassium channel, Alzheimer’ Disease Genetic Consortium, Clinical Sciences, Neurology & Neurosurgery
Abstract

Hippocampal sclerosis of aging (HS-Aging) is a high-morbidity brain disease in the elderly but risk factors are largely unknown. We report the first genome-wide association study (GWAS) with HS-Aging pathology as an endophenotype. In collaboration with the Alzheimer's Disease Genetics Consortium, data were analyzed from large autopsy cohorts: (#1) National Alzheimer's Coordinating Center (NACC); (#2) Rush University Religious Orders Study and Memory and Aging Project; (#3) Group Health Research Institute Adult Changes in Thought study; (#4) University of California at Irvine 90+ Study; and (#5) University of Kentucky Alzheimer's Disease Center. Altogether, 363 HS-Aging cases and 2,303 controls, all pathologically confirmed, provided statistical power to test for risk alleles with large effect size. A two-tier study design included GWAS from cohorts #1-3 (Stage I) to identify promising SNP candidates, followed by focused evaluation of particular SNPs in cohorts #4-5 (Stage II). Polymorphism in the ATP-binding cassette, sub-family C member 9 (ABCC9) gene, also known as sulfonylurea receptor 2, was associated with HS-Aging pathology. In the meta-analyzed Stage I GWAS, ABCC9 polymorphisms yielded the lowest p values, and factoring in the Stage II results, the meta-analyzed risk SNP (rs704178:G) attained genome-wide statistical significance (p = 1.4 × 10(-9)), with odds ratio (OR) of 2.13 (recessive mode of inheritance). For SNPs previously linked to hippocampal sclerosis, meta-analyses of Stage I results show OR = 1.16 for rs5848 (GRN) and OR = 1.22 rs1990622 (TMEM106B), with the risk alleles as previously described. Sulfonylureas, a widely prescribed drug class used to treat diabetes, also modify human ABCC9 protein function. A subsample of patients from the NACC database (n = 624) were identified who were older than age 85 at death with known drug history. Controlling for important confounders such as diabetes itself, exposure to a sulfonylurea drug was associated with risk for HS-Aging pathology (p = 0.03). Thus, we describe a novel and targetable dementia risk factor.

Published
2014

11. In Reply:.

Author

Pavlik, Edward John, Lasher, Anne, Harris, Lauren E., Solomon, Angelica L., Harbin, Laura M., Raby, Lauren, Dietrich, Charles S., Kryscio, Richard J., and van Nagell Jr, John R.

Published
2024
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12. Erratum

Author

Murphy, M Paul, Morales, Jacqueline, Beckett, Tina L, Astarita, Giuseppe, Piomelli, Daniele, Weidner, Adam, Studzinski, Christa M, Dowling, Amy LS, Wang, Xiaohong, LeVine, Harry, Kryscio, Richard J, Lin, Yushun, Barrett, Edward, and Head, Elizabeth

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Published
2011

13. Changes in Cognition and Amyloid-β Processing with Long Term Cholesterol Reduction using Atorvastatin in Aged Dogs

Author

Murphy, M Paul, Morales, Jacqueline, Beckett, Tina L, Astarita, Giuseppe, Piomelli, Daniele, Weidner, Adam, Studzinski, Christa M, Dowling, Amy LS, Wang, Xiaohong, LeVine, III, Harry, Kryscio, Richard J, Lin, Yushun, Barrett, Edward, and Head, Elizabeth

Subjects
Biological Psychology, Psychology, Alzheimer's Disease, Behavioral and Social Science, Neurodegenerative, Aging, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Dementia, Neurosciences, Brain Disorders, Mental health, Neurological, Amyloid beta-Peptides, Animals, Anticholesteremic Agents, Atorvastatin, Cholesterol, Cognition, Discrimination Learning, Dogs, Female, Heptanoic Acids, Male, Protein Processing, Post-Translational, Psychomotor Performance, Pyrroles, Random Allocation, Time Factors, Amyloid-beta protein precursor, beta-secretase, canine, cholesterol, dog, LRP-1, statin, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

Human studies suggest either a protective role or no benefit of statins against the development of Alzheimer's disease (AD). We tested the hypothesis that statin-mediated cholesterol reduction in aged dogs, which have cognitive impairments and amyloid-β (Aβ) pathology, would improve cognition and reduce neuropathology. In a study of 12 animals, we treated dogs with 80 mg/day of atorvastatin for 14.5 months. We did not observe improvements in discrimination learning; however, there were transient impairments in reversal learning, suggesting frontal dysfunction. Spatial memory function did not change with treatment. Peripheral levels of cholesterol, LDLs, triglycerides, and HDL were significantly reduced in treated dogs. Aβ in cerebrospinal fluid and brain remained unaffected. However, β-secretase-1 (BACE1) protein levels and activity decreased and correlated with reduced brain cholesterol. Finally, lipidomic analysis revealed a significant decrease in the ratio of omega-6 to omega-3 essential fatty in temporal cortex of treated aged dogs. Aged beagles are a unique model that may provide novel insights and translational data that can predict outcomes of statin use in human clinical trials. Treatment with atorvastatin may be beneficial for brain aging by reducing BACE1 protein and omega6:omega3 ratio, however, the potential adverse cognitive outcomes reported here should be more carefully explored given their relevance to human clinical outcomes.

Published
2010

16. Brain pathologies in extreme old age

Author

Neltner, Janna H., Abner, Erin L., Jicha, Gregory A., Schmitt, Frederick A., Patel, Ela, Poon, Leonard W., Marla, Gearing, Green, Robert C., Davey, Adam, Johnson, Mary Ann, Jazwinski, S. Michal, Kim, Sangkyu, Davis, Daron, Woodard, John L., Kryscio, Richard J., Van Eldik, Linda J., and Nelson, Peter T.

Published
2016
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17. Estimating random effects in a finite Markov chain with absorbing states: Application to cognitive data.

Author

Wang, Pei, Abner, Erin L., Liu, Changrui, Fardo, David W., Schmitt, Frederick A., Jicha, Gregory A., Van Eldik, Linda J., and Kryscio, Richard J.

Subjects
MARKOV processes, PANEL analysis, HESSIAN matrices, RANDOM matrices, MATRIX functions, COGNITIVE computing, COVARIANCE matrices
Abstract

Finite Markov chains with absorbing states are popular tools for analyzing longitudinal data with categorical responses. The one step transition probabilities can be defined in terms of fixed and random effects but it is difficult to estimate these effects due to many unknown parameters. In this article we propose a three‐step estimation method. In the first step the fixed effects are estimated by using a marginal likelihood function, in the second step the random effects are estimated after substituting the estimated fixed effects into a joint likelihood function defined as a h‐likelihood, and in the third step the covariance matrix for the vector of random effects is estimated using the Hessian matrix for this likelihood function. An application involving an analysis of longitudinal cognitive data is used to illustrate the method. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Kinematic measurements of the vocal-fold displacement waveform in typical children and adult populations: quantification of high-speed endoscopic videos

Author

Patel, Rita, Donohue, Kevin D., Unnikrishnan, Harikrishnan, and Kryscio, Richard J.

Subjects
Kinematics -- Measurement, Hoarseness -- Research, Waveforms -- Analysis, Health
Abstract

Purpose: This article presents a quantitative method for assessing instantaneous and average lateral vocal-fold motion from high-speed digital imaging, with a focus on developmental changes in vocal-fold kinematics during childhood. Method: Vocal-fold vibrations were analyzed for 28 children (aged 5-11 years) and 28 adults (aged 21-45 years) without voice disorders. The following kinematic features were analyzed from the vocal-fold displacement waveforms: relative velocity-based features (normalized average and peak opening and closing velocities), relative acceleration-based features (normalized peak opening and closing accelerations), speed quotient, and normalized peak displacement. Results: Children exhibited significantly larger normalized peak displacements, normalized average and peak opening velocities, normalized average and peak closing velocities, peak opening and closing accelerations, and speed quotient compared to adult women. Values of normalized average closing velocity and speed quotient were higher in children compared to adult men. Conclusions: When compared to adult men, developing children typically have higher estimates of kinematic features related to normalized displacement and its derivatives. In most cases, the kinematic features of children are closer to those of adult men than adult women. Even though boys experience greater changes in glottal length and pitch as they mature, results indicate that girls experience greater changes in kinematic features compared to boys., The prevalence of hoarseness among school-age children ranges from 0.12% (McKinnon, McLeod, & Reilly, 2007) to 15.80% (Kallvik, Lindstrom, Holmqvist, Lindman, & Simberg, 2014). Early identification of lesion formation is [...]

Published
2015
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37. Epidemic and Genetic Models

Author

Heyde, C. C., Kryscio, Richard J., Miller, Douglas R., Tavaré, Simon, Esty, Warren W., O'Cinneide, Colm Art, Kocherlakota, R. R., Shukla, Rakesh K., and Srivastava, R. C.

Published
1984
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