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359 results on '"Knake, Susanne"'

1. First epileptic seizure and epilepsies in adulthood: Abridged version of the S2k guideline of the German Society for Neurology in cooperation with the German Society for Epileptology. English Version

Author

Holtkamp, Martin, May, Theodor W., Berkenfeld, Ralf, Bien, Christian G., Coban, Ingrid, Knake, Susanne, Michaelis, Rosa, Rémi, Jan, Seeck, Margitta, Surges, Rainer, Weber, Yvonne, Baum, Petra, Baumgartner, Christoph, Beyenburg, Stefan, Brandt, Christian, Brodisch, Peter, Brückner, Sabine, Chatzikonstantinou, Anastasios, Conrad, Stefan, Fauser, Susanne, Focke, Niels, Freiman, Thomas, Freitag, Hedwig, Fudali, Monika, Geiger-Riess, Mirijam, Greshake, Benedikt, Grimmer, Anja, Hebel, Jonas, Held, Lynna, Kaufmann, Elisabeth, Kerling, Frank, Knieß, Tobias, Kollmar, Rainer, Krämer, Günter, Kürsten, Kathrin, Laufs, Helmut, Lüsebrink, Arne, Lutz, Martin, Möddel, Gabriel, Müffelmann, Birgitt, Noachtar, Soheyl, Rösche, Johannes, Rozinat, Klaus, Rüegg, Stephan, Schäfer, Ulrike, Schmidt, Pia Magdalena, Schmitt, Friedhelm C., Schmitt, Jörg, Schneider, Ulf C., Schulze-Bonhage, Andreas, Speicher, Pascal, Strzelczyk, Adam, Stutterheim, Katrin, Thorbecke, Rupprecht, Trollmann, Regina, Urbach, Horst, von Oertzen, Tim J., von Podewils, Felix, von Wrede, Randi, Wagner, Kathrin, Weber, Raimund, Wehner, Tim, Wendtland, Frank, Winter, Yaroslav, Woermann, Friedrich, and Zieglgänsberger, Dominik

Published
2024
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2. Erster epileptischer Anfall und Epilepsien im Erwachsenenalter: Kurzfassung S2k-Leitlinie der Deutschen Gesellschaft für Neurologie in Zusammenarbeit mit der Deutschen Gesellschaft für Epileptologie

Author

Holtkamp, Martin, May, Theodor W., Berkenfeld, Ralf, Bien, Christian G., Coban, Ingrid, Knake, Susanne, Michaelis, Rosa, Rémi, Jan, Seeck, Margitta, Surges, Rainer, Weber, Yvonne, Baum, Petra, Baumgartner, Christoph, Beyenburg, Stefan, Brandt, Christian, Brodisch, Peter, Brückner, Sabine, Chatzikonstantinou, Anastasios, Conrad, Stefan, Fauser, Susanne, Focke, Niels, Freiman, Thomas, Freitag, Hedwig, Fudali, Monika, Geiger-Riess, Mirijam, Greshake, Benedikt, Grimmer, Anja, Hebel, Jonas, Held, Lynna, Kaufmann, Elisabeth, Kerling, Frank, Knieß, Tobias, Kollmar, Rainer, Krämer, Günter, Kürsten, Kathrin, Laufs, Helmut, Lüsebrink, Arne, Lutz, Martin, Möddel, Gabriel, Müffelmann, Birgitt, Noachtar, Soheyl, Rösche, Johannes, Rozinat, Klaus, Rüegg, Stephan, Schäfer, Ulrike, Schmidt, Pia Magdalena, Schmitt, Friedhelm C., Schmitt, Jörg, Schneider, Ulf C., Schulze-Bonhage, Andreas, Speicher, Pascal, Strzelczyk, Adam, Stutterheim, Katrin, Thorbecke, Rupprecht, Trollmann, Regina, Urbach, Horst, von Oertzen, Tim J., von Podewils, Felix, von Wrede, Randi, Wagner, Kathrin, Weber, Raimund, Wehner, Tim, Wendtland, Frank, Winter, Yaroslav, Woermann, Friedrich, and Zieglgänsberger, Dominik

Published
2024
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5. A multicenter, matched case–control analysis comparing burden of illness among patients with tuberous sclerosis complex related epilepsy, generalized idiopathic epilepsy, and focal epilepsy in Germany

Author

Lappe, Lisa, Hertzberg, Christoph, Knake, Susanne, Knuf, Markus, von Podewils, Felix, Willems, Laurent M., Kovac, Stjepana, Zöllner, Johann Philipp, Sauter, Matthias, Kurlemann, Gerhard, Mayer, Thomas, Bertsche, Astrid, Marquard, Klaus, Meyer, Sascha, Schäfer, Hannah, Thiels, Charlotte, Zukunft, Bianca, Schubert-Bast, Susanne, Reese, Jens-Peter, Rosenow, Felix, and Strzelczyk, Adam

Published
2024
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7. Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review

Author

Rickel, Johanna K., Zeeb, Daria, Knake, Susanne, Urban, Hans, Konczalla, Jürgen, Weber, Katharina J., Zeiner, Pia S., Pagenstecher, Axel, Hattingen, Elke, Kemmling, André, Fokas, Emmanouil, Adeberg, Sebastian, Wolff, Robert, Sebastian, Martin, Rusch, Tillmann, Ronellenfitsch, Michael W., Menzler, Katja, Habermehl, Lena, Möller, Leona, Czabanka, Marcus, Nimsky, Christopher, Timmermann, Lars, Grefkes, Christian, Steinbach, Joachim P., Rosenow, Felix, Kämppi, Leena, and Strzelczyk, Adam

Published
2024
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20. Ultra-Rare Genetic Variation in the Epilepsies: A Whole-Exome Sequencing Study of 17,606 Individuals

Author

Collaborative, Epi25, Feng, Yen-Chen Anne, Howrigan, Daniel P, Abbott, Liam E, Tashman, Katherine, Cerrato, Felecia, Singh, Tarjinder, Heyne, Henrike, Byrnes, Andrea, Churchhouse, Claire, Watts, Nick, Solomonson, Matthew, Lal, Dennis, Heinzen, Erin L, Dhindsa, Ryan S, Stanley, Kate E, Cavalleri, Gianpiero L, Hakonarson, Hakon, Helbig, Ingo, Krause, Roland, May, Patrick, Weckhuysen, Sarah, Petrovski, Slavé, Kamalakaran, Sitharthan, Sisodiya, Sanjay M, Cossette, Patrick, Cotsapas, Chris, De Jonghe, Peter, Dixon-Salazar, Tracy, Guerrini, Renzo, Kwan, Patrick, Marson, Anthony G, Stewart, Randy, Depondt, Chantal, Dlugos, Dennis J, Scheffer, Ingrid E, Striano, Pasquale, Freyer, Catharine, McKenna, Kevin, Regan, Brigid M, Bellows, Susannah T, Leu, Costin, Bennett, Caitlin A, Johns, Esther MC, Macdonald, Alexandra, Shilling, Hannah, Burgess, Rosemary, Weckhuysen, Dorien, Bahlo, Melanie, O’Brien, Terence J, Todaro, Marian, Stamberger, Hannah, Andrade, Danielle M, Sadoway, Tara R, Mo, Kelly, Krestel, Heinz, Gallati, Sabina, Papacostas, Savvas S, Kousiappa, Ioanna, Tanteles, George A, Štěrbová, Katalin, Vlčková, Markéta, Sedláčková, Lucie, Laššuthová, Petra, Klein, Karl Martin, Rosenow, Felix, Reif, Philipp S, Knake, Susanne, Kunz, Wolfram S, Zsurka, Gábor, Elger, Christian E, Bauer, Jürgen, Rademacher, Michael, Pendziwiat, Manuela, Muhle, Hiltrud, Rademacher, Annika, van Baalen, Andreas, von Spiczak, Sarah, Stephani, Ulrich, Afawi, Zaid, Korczyn, Amos D, Kanaan, Moien, Canavati, Christina, Kurlemann, Gerhard, Müller-Schlüter, Karen, Kluger, Gerhard, Häusler, Martin, Blatt, Ilan, Lemke, Johannes R, Krey, Ilona, Weber, Yvonne G, Wolking, Stefan, Becker, Felicitas, Hengsbach, Christian, Rau, Sarah, Maisch, Ana F, Steinhoff, Bernhard J, Schulze-Bonhage, Andreas, Schubert-Bast, Susanne, and Schreiber, Herbert

Subjects
Clinical Research, Human Genome, Neurosciences, Epilepsy, Biotechnology, Genetics, Neurodegenerative, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Case-Control Studies, DNA Mutational Analysis, Exome, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Humans, Phenotype, Exome Sequencing, Epi25 Collaborative. Electronic address: s.berkovic@unimelb.edu.au, Epi25 Collaborative, burden analysis, epilepsy, epileptic encephalopathy, exome, seizures, sequencing, Biological Sciences, Medical and Health Sciences, Genetics & Heredity
Abstract

Sequencing-based studies have identified novel risk genes associated with severe epilepsies and revealed an excess of rare deleterious variation in less-severe forms of epilepsy. To identify the shared and distinct ultra-rare genetic risk factors for different types of epilepsies, we performed a whole-exome sequencing (WES) analysis of 9,170 epilepsy-affected individuals and 8,436 controls of European ancestry. We focused on three phenotypic groups: severe developmental and epileptic encephalopathies (DEEs), genetic generalized epilepsy (GGE), and non-acquired focal epilepsy (NAFE). We observed that compared to controls, individuals with any type of epilepsy carried an excess of ultra-rare, deleterious variants in constrained genes and in genes previously associated with epilepsy; we saw the strongest enrichment in individuals with DEEs and the least strong in individuals with NAFE. Moreover, we found that inhibitory GABAA receptor genes were enriched for missense variants across all three classes of epilepsy, whereas no enrichment was seen in excitatory receptor genes. The larger gene groups for the GABAergic pathway or cation channels also showed a significant mutational burden in DEEs and GGE. Although no single gene surpassed exome-wide significance among individuals with GGE or NAFE, highly constrained genes and genes encoding ion channels were among the lead associations; such genes included CACNA1G, EEF1A2, and GABRG2 for GGE and LGI1, TRIM3, and GABRG2 for NAFE. Our study, the largest epilepsy WES study to date, confirms a convergence in the genetics of severe and less-severe epilepsies associated with ultra-rare coding variation, and it highlights a ubiquitous role for GABAergic inhibition in epilepsy etiology.

Published
2019

28. Efficacy, Retention and Tolerability of Everolimus in Patients with Tuberous Sclerosis Complex: A Survey-Based Study on Patients’ Perspectives

Author

Willems, Laurent M., Rosenow, Felix, Schubert-Bast, Susanne, Kurlemann, Gerhard, Zöllner, Johann Philipp, Bast, Thomas, Bertsche, Astrid, Bettendorf, Ulrich, Ebrahimi-Fakhari, Daniel, Grau, Janina, Hahn, Andreas, Hartmann, Hans, Hertzberg, Christoph, Hornemann, Frauke, Immisch, Ilka, Jacobs, Julia, Klein, Karl Martin, Klotz, Kerstin A., Kluger, Gerhard, Knake, Susanne, Knuf, Markus, Marquard, Klaus, Mayer, Thomas, Meyer, Sascha, Muhle, Hiltrud, Müller-Schlüter, Karen, von Podewils, Felix, Ruf, Susanne, Sauter, Matthias, Schäfer, Hannah, Schlump, Jan-Ulrich, Syrbe, Steffen, Thiels, Charlotte, Trollmann, Regina, Wiemer-Kruel, Adelheid, Wilken, Bernd, Zukunft, Bianca, and Strzelczyk, Adam

Published
2021
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33. Consultation Requests and Satisfaction with a Telehealth Network for Epilepsy: Longitudinal Analysis of the Epilepsy Network Hessen Evaluation.

Author

Zöllner, Johann Philipp, Rosenow, Felix, Schubert-Bast, Susanne, Roth, Christian, Knake, Susanne, Eickhoff, Clemens, Scheuble, Pascal, Martin, Jürgen, Bollensen, Edgar, Teepker, Michael, Singer, Oliver, Schirmer, Svenja, Dietz, Andreas, Henn, Karl-Heinz, Stolz, Erwin, Schüttler-Gahin, Katrin, Fischer, Michaela, Noda, Anna, Mann, Catrin, and Strzelczyk, Adam

Subjects
EPILEPSY, SATISFACTION, MAGNETIC resonance imaging, PHYSICIANS, CHILD patients, TELEMEDICINE
Abstract

Background: Telemedicine improves access to specialized medical expertise, as required for paroxysmal disorders. The Epilepsy Network Hessen Evaluation (ENHE) is a pilot cross-sectoral teleconsultation network connecting primary neurologists and pediatricians with epilepsy centers in Hessen, a federal German state. Methods: We prospectively and longitudinally evaluated telehealthcare in the ENHE. Participating physicians rated each consultation for satisfaction and impact on further management. The survey was administered at each consultation and 3 months later. Results: We analyzed 129 consultations involving 114 adult and pediatric patients. Their mean age was 34 years (standard deviation: 26, range: 0.1–91 years), 48% were female, and 34% were children and adolescents. The most common consultation requests were co-evaluation of an electroencephalogram (electroencephalogram [EEG]; 76%) and therapeutic (33%) and differential diagnosis (24%) concerns. Physicians transmitted one paraclinical examination on average (range: 1–4), predominantly EEG (85%), followed by magnetic resonance imaging (17%) and written records (9%). Response rates were 72% for the initial and 67% for the follow-up survey. Across respondents, 99% (n = 92) were satisfied with the ENHE. Overall, 80% of the consultations contributed to the diagnosis, and 90% were considered helpful for treatment, influencing it in 71% of cases. Seizure frequency had decreased more often (96%) than increased (4%) at 3 months. The initial diagnosis was confirmed in 78% of patients. Discussion: In this pilot teleconsultation network for paroxysmal disorders, diagnostic and therapeutic advice was perceived as helpful. Clinical outcomes were largely positive, suggesting tele-epileptology is viable for paroxysmal (seizure) disorders. [ABSTRACT FROM AUTHOR]

Published
2024
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34. A multicenter randomized controlled feasibility trial of a digital self‐management intervention for adults with epilepsy.

Author

Michaelis, Rosa, Knake, Susanne, Rosenow, Felix, Grönheit, Wenke, Hamer, Hajo, Schmitz, Bettina, Accarie, Alison, Dedeken, Peter, Immisch, Ilka, Habermehl, Lena, Zöllner, Johann Philipp, Mann, Catrin, Wehner, Tim, Wellmer, Jörg, Cuny, Jeanne, Gollwitzer, Stephanie, Losch, Florian, Krämer, Kirsten, Voss, Kevin Steffen, and Heinen, Gerd

Subjects
RANDOMIZED controlled trials, EPILEPSY, PATIENT participation, PATIENT autonomy, HEALTH literacy, TRANSCRANIAL direct current stimulation, BLACKBERRIES
Abstract

Objective: Self‐management interventions may enhance health‐related quality of life (HRQoL) in epilepsy. However, several barriers often impair their implementation in the real world. Digital interventions may help to overcome some of these barriers. Considering this, the Helpilepsy Plus Prototype was developed as a prototype smartphone‐delivered self‐care treatment program for adults with epilepsy. Methods: The 12‐week Helpilepsy Plus Prototype was evaluated through a randomized controlled feasibility trial with a waiting‐list control (WLC) group. Outcome measurement at baseline and at 12 weeks assessed adherence to the prototype intervention and changes in epilepsy‐related outcomes. The primary endpoint was patient autonomy measured with EASE, and secondary endpoints included HRQoL measured with QOLIE‐31, health literacy measured with HLQ, anxiety, and depression symptoms measured with HADS. Semi‐structured interviews were conducted with a heterogeneous sample of participants to assess user‐friendliness and usefulness. The prototype program was delivered through the Neuroventis Platform (Neuroventis, BV, Overijse, Belgium), a certified medical device (under EU/MDD Class I, and EU/MDR grace period). Results: Ninety‐two patients were included (46 in the intervention group, 46 in WLC). Most participants (63%, 58/92 women, median age 30 years) had pharmacoresistant epilepsy (61%, 56/92). Only 22% of participants (10/46) in the intervention group completed at least half of all intervention sessions. No significant differences between the intervention group and WLC were observed. Although there was a larger proportion of patients in the intervention group with meaningful improvements in HRQoL compared to WLC (19/46 versus 11/46), the difference was not significant (p = 0.119). Qualitative feedback showed that participants would appreciate more personalization, such as adaptation of the content to their current epilepsy knowledge level, a more interactive interface, shorter text sections, and interaction through reminders and notifications. Significance: Digital interventions should allow sufficient scope for personalization and interaction to increase patient engagement and enable benefits from self‐care apps. Feedback loops allow the participatory development of tailored interventions. Plain Language Summary: In this study, we investigated the effectiveness of an app‐based self‐help intervention. Study participants were either randomly assigned to a group that had access to the app or a group that received access to the app after the end of the study. Although a larger proportion of participants in the intervention group showed a relevant improvement in quality of life, the difference between the two groups was not statistically significant. Less than one‐fifth of participants in the intervention group attended at least half of all intervention sessions; patient feedback showed that patients required more personalization and interactive options. [ABSTRACT FROM AUTHOR]

Published
2024
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35. FASTMAP--a flexible and scalable immunopeptidomics pipeline for HLA- and antigen-specific T-cell epitope mapping based on artificial antigen-presenting cells.

Author

Weisbrod, Luisa, Capriotti, Luigi, Hofmann, Marco, Spieler, Valerie, Dersch, Herbert, Voedisch, Bernd, Schmidt, Peter, and Knake, Susanne

Subjects
T cell receptors, ARTIFICIAL cells, MYELIN basic protein, T cells, HLA histocompatibility antigens, TANDEM mass spectrometry
Abstract

The study of peptide repertoires presented by major histocompatibility complex (MHC) molecules and the identification of potential T-cell epitopes contribute to a multitude of immunopeptidome-based treatment approaches. Epitope mapping is essential for the development of promising epitope-based approaches in vaccination as well as for innovative therapeutics for autoimmune diseases, infectious diseases, and cancer. It also plays a critical role in the immunogenicity assessment of protein therapeutics with regard to safety and efficacy concerns. The main challenge emerges from the highly polymorphic nature of the human leukocyte antigen (HLA) molecules leading to the requirement of a peptide mapping strategy for a single HLA allele. As many autoimmune diseases are linked to at least one specific antigen, we established FASTMAP, an innovative strategy to transiently co-transfect a single HLA allele combined with a diseasespecific antigen into a human cell line. This approach allows the specific identification of HLA-bound peptides using liquid chromatography--tandem mass spectrometry (LC-MS/MS). Using FASTMAP, we found a comparable spectrum of endogenous peptides presented by the most frequently expressed HLA alleles in the world's population compared to what has been described in literature. To ensure a reliable peptide mapping workflow, we combined the HLA alleles with well-known human model antigens like coagulation factor VIII, acetylcholine receptor subunit alpha, protein structures of the SARS-CoV-2 virus, and myelin basic protein. Using these model antigens, we have been able to identify a broad range of peptides that are in line with already published and in silico predicted T-cell epitopes of the specific HLA/model antigen combination. The transient co-expression of a single affinity-tagged MHC molecule combined with a disease-specific antigen in a human cell line in our FASTMAP pipeline provides the opportunity to identify potential T-cell epitopes/endogenously processed MHC-bound peptides in a very cost-effective, fast, and customizable system with high-throughput potential. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J

Published
2020
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38. Could the 2017 ILAE and the four-dimensional epilepsy classifications be merged to a new “Integrated Epilepsy Classification”?

Author

Rosenow, Felix, Akamatsu, Naoki, Bast, Thomas, Bauer, Sebastian, Baumgartner, Christoph, Benbadis, Selim, Bermeo-Ovalle, Adriana, Beyenburg, Stefan, Bleasel, Andrew, Bozorgi, Alireza, Brázdil, Milan, Carreño, Mar, Delanty, Norman, Devereaux, Michael, Duncan, John, Fernandez-Baca Vaca, Guadalupe, Francione, Stefano, García Losarcos, Naiara, Ghanma, Lauren, Gil-Nagel, Antonio, Hamer, Hajo, Holthausen, Hans, Omidi, Shirin Jamal, Kahane, Philippe, Kalamangalam, Giri, Kanner, Andrés, Knake, Susanne, Kovac, Stjepana, Krakow, Karsten, Krämer, Günter, Kurlemann, Gerhard, Lacuey, Nuria, Landazuri, Patrick, Lim, Shi Hui, Londoño, Luisa V., LoRusso, Giorgio, Luders, Hans, Mani, Jayanti, Matsumoto, Riki, Miller, Jonathan, Noachtar, Soheyl, O’Dwyer, Rebecca, Palmini, André, Park, Jun, Reif, Philipp S., Remi, Jan, Sakamoto, Americo C., Schmitz, Bettina, Schubert-Bast, Susanne, Schuele, Stephan, Shahid, Asim, Steinhoff, Bernhard, Strzelczyk, Adam, Szabo, C. Akos, Tandon, Nitin, Terada, Kiyohito, Toledo, Manuel, van Emde Boas, Walter, Walker, Matthew, and Widdess-Walsh, Peter

Published
2020
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42. Direct and indirect costs and cost-driving factors in adults with tuberous sclerosis complex: a multicenter cohort study and a review of the literature

Author

Zöllner, Johann Philipp, Grau, Janina, Rosenow, Felix, Sauter, Matthias, Knuf, Markus, Kurlemann, Gerhard, Mayer, Thomas, Hertzberg, Christoph, Bertsche, Astrid, Immisch, Ilka, Klein, Karl Martin, Knake, Susanne, Marquard, Klaus, Meyer, Sascha, Noda, Anna H., von Podewils, Felix, Schäfer, Hannah, Thiels, Charlotte, Willems, Laurent M., Zukunft, Bianca, Schubert-Bast, Susanne, and Strzelczyk, Adam

Published
2021
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43. Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Author

Conradi, Nadine, Rosenberg, Friederike, Knake, Susanne, Biermann, Louise, Haag, Anja, Gorny, Iris, Hermsen, Anke, von Podewils, Viola, Behrens, Marion, Gurschi, Marianna, du Mesnil de Rochemont, Richard, Menzler, Katja, Bauer, Sebastian, Schubert-Bast, Susanne, Nimsky, Christopher, Konczalla, Jürgen, Rosenow, Felix, and Strzelczyk, Adam

Published
2021
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44. Quality of life and its predictors in adults with tuberous sclerosis complex (TSC): a multicentre cohort study from Germany

Author

Zöllner, Johann Philipp, Conradi, Nadine, Sauter, Matthias, Knuf, Markus, Knake, Susanne, Kurlemann, Gerhard, Mayer, Thomas, Hertzberg, Christoph, Bertsche, Astrid, Immisch, Ilka, Klein, Karl Martin, Marquard, Klaus, Meyer, Sascha, Noda, Anna H., von Podewils, Felix, Schäfer, Hannah, Thiels, Charlotte, Zukunft, Bianca, Schubert-Bast, Susanne, Grau, Janina, Willems, Laurent M., Rosenow, Felix, Reese, Jens-Peter, and Strzelczyk, Adam

Published
2021
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47. Quality of life and correlating factors in children, adolescents with epilepsy, and their caregivers: A cross-sectional multicenter study from Germany

Author

Riechmann, Janna, Willems, Laurent M., Boor, Rainer, Kieslich, Matthias, Knake, Susanne, Langner, Cornelia, Neubauer, Bernd A., Oberman, Bettina, Philippi, Heike, Reese, Jens P., Rochel, Michael, Schubert-Bast, Susanne, Seeger, Jürgen, Seipelt, Peter, Stephani, Ulrich, Rosenow, Felix, Hamer, Hajo M., and Strzelczyk, Adam

Published
2019
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48. In response to commentary on cavernoma‐related epilepsy: Review and recommendations for management—Report of the surgical task force of the ILAE commission on therapeutic strategies

Author

Rosenow, Felix, Alonso‐Vanegas, Mario A, Baumgartner, Christoph, Blümcke, Ingmar, Carreño, Mar, Gizewski, Elke R, Hamer, Hajo M, Knake, Susanne, Kahane, Philippe, Lüders, Hans O, Mathern, Gary W, Menzler, Katja, Miller, Jonathan, Otsuki, Taisuke, Ozkara, Cigdem, Pitkänen, Asla, Roper, Steven N, Sakamoto, Americo C, Sure, Ulrich, Walker, Matthew C, Steinhoff, Bernhard J, and Force, Commission on Therapeutic Strategies of the ILAE the Surgical Task

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Neoplasms, Epilepsy, Hemangioma, Cavernous, Central Nervous System, Humans, Surgical Task Force, Commission on Therapeutic Strategies of the ILAE, Neurosciences, Neurology & Neurosurgery, Clinical sciences
Published
2014

49. Morphometric magnetic resonance imaging (MRI) postprocessing in MRI‐negative patients with first unprovoked seizure.

Author

Tsalouchidou, Panagiota‐Eleni, Hoffmann, Johanna, Strehlau, Sascha, Linka, Louise, Belke, Marcus, Habermehl, Lena, Schulze, Maximilian, Kemmling, André, Menzler, Katja, and Knake, Susanne

Subjects
EPILEPSY, MAGNETIC resonance imaging, FOCAL cortical dysplasia, SEIZURES (Medicine), DIAGNOSIS of epilepsy, PEOPLE with epilepsy
Abstract

Objective: The aim of the study was to evaluate the benefits of morphometric magnetic resonance imaging (MRI) postprocessing in patients presenting with a first seizure and negative MRI results and to investigate these findings in the context of the clinical and electroencephalographic data, seizure recurrence rates, and epilepsy diagnosis in these patients. Methods: We retrospectively reviewed 97 MRI scans of patients with first unprovoked epileptic seizure and no evidence of epileptogenic lesion on clinical routine MRI. Morphometric Analysis Program (MAP; v2018), automated postprocessing software, was used to identify subtle, potentially epileptogenic lesions in the three‐dimensional T1‐weighted MRI data. The resulting probability maps were examined together with the conventional MRI images by a reviewer who remained blinded to the patients' clinical and electroencephalographical data. Clinical data were prospectively collected between February 2018 and May 2023. Results: Among the apparently MRI‐negative patients, a total of 18 of 97 (18.6%) showed cortical changes suggestive of focal cortical dysplasia. Within the population with positive MAP findings (MAP+), seizure recurrence rates were 61.1% and 66.7% at 1 and 2 years after the first unprovoked seizure, respectively. Conversely, patients with negative MAP findings (MAP−) had lower seizure recurrence rates of 27.8% and 34.2% at 1 and 2 years after the first unprovoked seizure, respectively. Patients with MAP+ findings were significantly more likely to be diagnosed with epilepsy than those patients with MAP− findings (χ2 [1, n = 97] = 14.820, p <.001, odds ratio = 21.371, 95% CI = 2.710–168.531) during a mean follow‐up time of 22.51 months (SD = 16.7 months, range = 1–61 months). Significance: MRI postprocessing can be a valuable tool for detecting subtle epileptogenic lesions in patients with a first seizure and negative MRI results. Patients with first seizure and MAP+ findings had high seizure recurrence rates, meeting the criteria for beginning epilepsy. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Undiagnosed obstructive sleep apnea syndrome as a treatable cause of new‐onset sleepiness in some post‐COVID patients.

Author

Menzler, Katja, Mayr, Petra, Knake, Susanne, Cassel, Werner, Viniol, Christian, Reitz, Lena, Tsalouchidou, Panagiota‐Eleni, Janzen, Annette, Anschuetz, Katja, Mross, Peter, and Koehler, Ulrich

Subjects
SLEEP apnea syndromes, HYPERSOMNIA, POST-acute COVID-19 syndrome, COVID-19 pandemic, COVID-19, DROWSINESS
Abstract

Background and purpose: Infection with COVID‐19 can lead to persistent sequelae, such as fatigue, daytime sleepiness or disturbed sleep, that can remain for more than 12 weeks and that are summarized as post‐COVID syndrome. The causes remain unclear. The present study investigated the presence of sleep disorders in patients with post‐COVID syndrome using polysomnography. Methods: Thirty‐four patients with post‐COVID syndrome and new‐onset fatigue and sleepiness after a SARS‐CoV2 infection underwent polysomnography in accordance with American Association of Sleep Medicine (AASM) standards as part of their clinical workup. Analysis was performed visually based on AASM criteria (scoring manual version 2.6, 2020). Results: Polysomnography revealed a sleep efficiency of <80% in 50% of patients and a mean respiratory disturbance index (RDI) of 9.9 ± 15.4/h. Excluding central apneas, 12 patients (35%) had an RDI of ≥5/h, pointing to obstructive sleep apnea syndrome (OSAS; AASM 2014). Patients with a high RDI were significantly older (p = 0.01) and showed a trend towards a higher body mass index (p = 0.08) than patients with a normal RDI but had no other risk factors for OSAS. Six patients agreed to long‐term treatment of their OSAS and all reported discontinuation of daytime symptoms. Conclusions: Post‐COVID symptoms such as daytime sleepiness, fatigue and memory and concentration problems may in part be a result of reduced sleep efficiency and sleep apnea in a relevant percentage of patients. This possibly treatable cause of the symptoms should be kept in mind in patients presenting with post‐COVID syndrome. [ABSTRACT FROM AUTHOR]

Published
2024
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