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14 results on '"Kiriakakis, M."'

1. Associations between food portion sizes, insulin resistance, VO2 max and metabolic syndrome in European adolescents: The HELENA study

Author

Coordinator, Moreno, L.A., Core Group members, Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Steering Committee, Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Project Manager, Meléndez, P., Casajús, J.A., Fleta, J., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Bueno, O., León, J.F., Garagorri, J.Ma, Labayen, I., Iglesia, I., Bel, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E., De Miguel-Etayo, P., Miguel-Berges, M., Iguacel, I., Rupérez, A., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, M., Nagy, E.ö, Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., former INRAN, Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thoma-IRs, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Flieh, S.M., Miguel-Berges, M.L., Gonzalez-Gross, M., Gesteiro, E., Abbeddou, S., and González-Gil, E.M.

Published
2022
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2. Correlates of ideal cardiovascular health in European adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Sánchez, J., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Revenga, J., Lachen, C., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Rey López, J.P., Iglesia, I., Velasco, P., Bel, S., Marcos, A., Wärnberg, J., Nova, E., Gómez-Martinez, S., Díaz, L.E., Romeo, J., Veses, A., Puertollano, M.A., Zapatera, B., Pozo, T., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Repásy, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España-Romero, V., Jiménez-Pavón, D., Chillón, P., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Widhalm, K., Phillipp, K., Dietrich, S., Kubelka, B., Boriss-Riedl, M., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Kondaki, K., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Bergman, P., Hagströmer, M., Hallström, L., Hallberg, M., Poortvliet, E., Rizzo, N., Beckman, L., Wennlöf, A.H., Patterson, E., Kwak, L., Cernerud, L., Tillgren, P., Sörensen, S., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Castelló, S., Thomas, S., Allchurch, E., Burguess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Valtueña, J., Albers, U., Pedrero, R., Meléndez, A., Benito, P.J., Calderón, J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Carlos Ortiz, J., Fuentes, F., María Torres, R., Navarro, P., Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., and Gracia-Marco, L.

Published
2018
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3. Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Labayen, I., Iglesia, I., Bel Serrat, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E.M., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E., Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Cadenas-Sanchez, C., Santabárbara, J., Bueno-Lozano, G., Siani, A., Amaro-Gahete, F., and Rupérez, A.I.

Published
2018
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4. Ideal cardiovascular health and inflammation in European adolescents: The HELENA study

Author

Moreno, L.A., Gottrand, F., De Henauw, S., González-Gross, M., Gilbert, C., Kafatos, A., Libersa, C., Castelló, S., Kersting, M., Sjöstrom, M., Molnár, D., Dallongeville, J., Hall, G., Maes, L., Scalfi, L., Meléndez, P., Fleta, J., Casajús, J.A., Rodríguez, G., Tomás, C., Mesana, M.I., Vicente-Rodríguez, G., Villarroya, A., Gil, C.M., Ara, I., Alvira, J.F., Bueno, G., Lázaro, A., Bueno, O., León, J.F., Garagorri, J.M<ce:sup loc='post">a</ce:sup>, Bueno, M., Labayen, I., Iglesia, I., Bel Serrat, S., Gracia Marco, L.A., Mouratidou, T., Santaliestra-Pasías, A., González-Gil, E.M., De Miguel-Etayo, P., Julián Almárcegui, C., Miguel-Berges, M., Iguacel, I., Marcos, A., Wärnberg, J., Nova, E., Gómez, S., Díaz, L.E., Romeo, J., Veses, A., Zapatera, B., Pozo, T., Martínez, D., Beghin, L., Iliescu, C., Von Berlepsch, J., Sichert-Hellert, W., Koeppen, E., Molnar, D., Erhardt, E., Csernus, K., Török, K., Bokor, S., Angster, Nagy, E.ö, Kovács, O., Répasi, J., Codrington, C., Plada, M., Papadaki, A., Sarri, K., Viskadourou, A., Hatzis, C., Kiriakakis, M., Tsibinos, G., Vardavas, C., Sbokos, M., Protoyeraki, E., Fasoulaki, M., Stehle, P., Pietrzik, K., Breidenassel, C., Spinneker, A., Al-Tahan, J., Segoviano, M., Berchtold, A., Bierschbach, C., Blatzheim, E., Schuch, A., Pickert, P., Castillo, M.J., Gutiérrez, Á., Ortega, F.B., Ruiz, J.R., Artero, E.G., España, V., Jiménez-Pavón, D., Chillón, P., Sánchez-Muñoz, C., Cuenca, M., Arcella, D., Azzini, E., Barrison, E., Bevilacqua, N., Buonocore, P., Catasta, G., Censi, L., Ciarapica, D., D'Acapito, P., Ferrari, M., Galfo, M., Le Donne, C., Leclercq, C., Maiani, G., Mauro, B., Mistura, L., Pasquali, A., Piccinelli, R., Polito, A., Roccaldo, R., Spada, R., Sette, S., Zaccaria, M., Vitaglione, P., Montagnese, C., De Bourdeaudhuij, I., De Vriendt, T., Matthys, C., Vereecken, C., de Maeyer, M., Ottevaere, C., Huybrechts, I., Widhalm, K., Phillipp, K., Dietrich, S., Manios, Y., Grammatikaki, E., Bouloubasi, Z., Cook, T.L., Eleutheriou, S., Consta, O., Moschonis, G., Katsaroli, I., Kraniou, G., Papoutsou, S., Keke, D., Petraki, I., Bellou, E., Tanagra, S., Kallianoti, K., Argyropoulou, D., Tsikrika, S., Karaiskos, C., Meirhaeghe, A., Hagströmer, M., Wennlöf, A.H., Hallström, L., Patterson, E., Kwak, L., Rizzo, N., Sánchez-Molero, J., Picó, E., Navarro, M., Viadel, B., Carreres, J.E., Merino, G., Sanjuán, R., Lorente, M., Sánchez, M.J., Thomas, S., Allchurch, E., Burgess, P., Astrom, A., Sverkén, A., Broberg, A., Masson, A., Lehoux, C., Brabant, P., Pate, P., Fontaine, L., Sebok, A., Kuti, T., Hegyi, A., Maldonado, C., Llorente, A., García, E., von Fircks, H., Hallberg, M.L., Messerer, M., Larsson, M., Fredriksson, H., Adamsson, V., Börjesson, I., Fernández, L., Smillie, L., Wills, J., Pedrero-Chamizo, R., Meléndez, A., Valtueña, J., Albers, U., Benito, P.J., Gómez Lorente, J.J., Cañada, D., Urzanqui, A., Torres, R.M., Navarro, P., Santabárbara, J., Bel-Serrat, S., de la O, A., Palacios Le Blé, G., Siani, A., Gómez-Martínez, S., and Moreno Aznar, L.A.

Published
2017
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6. Fatty acid and salt contents of snacks in the Cretan and Cypriot market: A child and adolescent dietary hazard

Author

Vardavas, C.I., Yiannopoulos, S., Kiriakakis, M., Poulli, E., and Kafatos, A.

Subjects
*SNACK foods, *FATTY acids, *NUTRITION disorders, *OBESITY
Abstract

Abstract: Adult, adolescent and childhood obesity is a growing public health problem, worldwide. The increase in the prevalence of obesity in children and adolescents is believed to be partly attributable to an increase in the consumption of snacks that are high in fat and sugar, and make up a substantial percentage of daily calorie intakes. Our results show a high to very high salt content in almost all of the brands analysed, with salt contents ranging from 0.8 to 3.9g per 100g of product (mean value 2.05±0.73g). The total fat content of brands differed, ranging from 9% to 46% (mean value 31±8.4%). Calories, due solely to fat, also ranged widely from 82 to 413kcal/100g of product with an average value of 283±76kcal. Our results underline the need for stricter regulations and/or the need to inform children and adolescents on the true content of such snacks. [Copyright &y& Elsevier]

Published
2007
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7. Endocrine disruptor compound's levels in hair of Greek children.

Author

Tzatzarakis, M.N., Karzi, V., Vakonaki, E., Katsikantami, I., Kiriakakis, M., Tsakiris, I., Kavvalakis, M., Rizos, A.K., and Tsatsakis, A.M.

Subjects
*ENDOCRINE disruptors, *PHYSIOLOGICAL effects of chemicals, *BISPHENOL A, *TRICLOSAN, *HYGIENE products, *LIQUID chromatography-mass spectrometry
Published
2016
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8. Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights.

Author

Spanakis M, Fragkiadaki P, Renieri E, Vakonaki E, Fragkiadoulaki I, Alegakis A, Kiriakakis M, Panagiotou N, Ntoumou E, Gratsias I, Zoubaneas E, Morozova GD, Ovchinnikova MA, Tsitsimpikou C, Tsarouhas K, Drakoulis N, Skalny AV, and Tsatsakis A

Abstract

In modern athlete assessment, the integration of conventional biochemical and ergophysiologic monitoring with innovative methods like telomere analysis, genotyping/phenotypic profiling, and metabolomics has the potential to offer a comprehensive understanding of athletes' performance and potential longevity. Telomeres provide insights into cellular functioning, aging, and adaptation and elucidate the effects of training on cellular health. Genotype/phenotype analysis explores genetic variations associated with athletic performance, injury predisposition, and recovery needs, enabling personalization of training plans and interventions. Metabolomics especially focusing on low-molecular weight metabolites, reveal metabolic pathways and responses to exercise. Biochemical tests assess key biomarkers related to energy metabolism, inflammation, and recovery. Essential elements depict the micronutrient status of the individual, which is critical for optimal performance. Echocardiography provides detailed monitoring of cardiac structure and function, while burnout testing evaluates psychological stress, fatigue, and readiness for optimal performance. By integrating this scientific testing battery, a multidimensional understanding of athlete health status can be achieved, leading to personalized interventions in training, nutrition, supplementation, injury prevention, and mental wellness support. This scientifically rigorous approach hereby presented holds significant potential for improving athletic performance and longevity through evidence-based, individualized interventions, contributing to advances in the field of sports performance optimization., Competing Interests: Authors MS, PF, ER, EV, IF, AA, MK, AT were employed by company LifePlus Diagnostic & Consulting Health Services. Authors NP, EN were employed by company iDNA Laboratories. EZ is employed by Diatrofi Center for Eating Disorders and Consultation. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (© 2024 Spanakis, Fragkiadaki, Renieri, Vakonaki, Fragkiadoulaki, Alegakis, Kiriakakis, Panagiotou, Ntoumou, Gratsias, Zoubaneas, Morozova, Ovchinnikova, Tsitsimpikou, Tsarouhas, Drakoulis, Skalny and Tsatsakis.)

Published
2024
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9. Seven Countries Study cohort in Crete, Greece: gluteal adipose-tissue fatty-acid profiles of survivors, at 2010.

Author

Papandreou C, Kiriakakis M, Fragkiadakis GA, Hatzis CM, and Kafatos AG

Subjects
Aged, 80 and over, Fatty Acids, Unsaturated analysis, Greece, Humans, Male, Oleic Acid analysis, Adipose Tissue chemistry, Aging, Fatty Acids analysis
Abstract

Objective: To analyse the gluteal adipose-tissue fatty-acid profiles from Cretan cohort survivors of the Seven Countries Study (SCS) at 2010 and to compare them with those of survivors assessed in 2000, as well as with literature data on male Cretans at 1965., Design: We analysed data concerning the gluteal adipose-tissue fatty acids (analysed by GC) from three studies., Setting: The island of Crete (rural areas and the city of Heraklion)., Subjects: Twenty-two of the 2010 SCS survivors aged 90 years and over; seventy-eight men aged 80 years of the 2000 SCS survivors; and 280 men assessed in 1965., Results: In comparison to 1965 and 2000, the SCS survivors in 2010 had a higher amount of 18:1n-9 (P<0·05) in their gluteal adipose tissue and a lower amount of PUFA (P<0·05). On the other hand, a constant decrease in adipose-tissue 14:1n-5 and 16:1n-7 was recorded between 1965 and 2010 (P<0·001), and between 2000 and 2010 (P<0·05), while 18:2n-6 appeared to decrease between the 1965 and 2010 assessments (P<0·001)., Conclusions: Comparison with a 1965 representative Cretan sample and 2000 SCS survivors indicated an increased concentration of oleic acid (known for its protective role against mortality) and a decreased concentration of PUFA (known for their susceptibility to oxidation) in our surviving sample at 2010. These changes may reflect internal physiological processes due to diet change within these years and/or ageing.

Published
2016
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10. Fatty acid composition of subcutaneous adipose tissue and gastric mucosa: is there a relation with gastric ulceration?

Author

Pagkalos VA, Moschandreas J, Kiriakakis M, Roussomoustakaki M, Kafatos A, and Kouroumalis E

Subjects
Adult, Aged, Buttocks, Case-Control Studies, Endoscopy, Female, Gastric Mucosa microbiology, Helicobacter Infections complications, Helicobacter Infections metabolism, Helicobacter Infections pathology, Helicobacter pylori, Humans, Male, Middle Aged, Stomach Ulcer microbiology, Young Adult, Fatty Acids metabolism, Gastric Mucosa metabolism, Stomach Ulcer metabolism, Stomach Ulcer pathology, Subcutaneous Fat, Abdominal metabolism
Abstract

Background: Both in vitro and epidemiological studies indicate that dietary polyunsaturated fatty acids may play a protective role against peptic ulcer in humans. Adipose tissue fatty acid composition is thought to reflect dietary fatty acid intake. The aim of the present study is to investigate adipose and gastric mucosa fatty acid levels in relation to gastric ulceration status., Methods: Fifty two adult outpatients undergoing upper gastrointestinal tract endoscopy participated in the study. Adipose tissue samples were taken from the abdomen and buttock during the endoscopy procedure and samples from gastric tissue were taken from a subsample of 30 subjects. The presence of Helicobacter pylori was determined using the CLO test. Capillary gas chromatography was used for the extraction of 36 and 42 adipose tissue and gastric mucosa lipids respectively., Results: The monounsaturated fatty acids (MUFAs) C18:1n-12c, C16:1n-5, C16:4n-1 and the polyunsaturated fatty acids (PUFAs) C16:3n-4, C20:3n-3, C20:4n-6, C21:5n-3 and C18:2n-9c,12t of the gastric mucosa were present in higher proportions in ulcer negative patients. These unsaturated fatty acids, however, each contributed less than 1% on average to total fatty acid content. In addition, higher average levels of eicosapentaenoic acid (EPA) C20:5n-3 and docosahexaenoic acid (DHA) C22:6n-3 were detected in abdominal and buttock samples in CLO negative controls, compared to CLO positive controls. Adipose tissue and gastric mucosa n-6 and trans fatty acid levels were positively linearly correlated (r = 0.37 and 0.41 for n-6 and trans fatty acids respectively)., Conclusion: Certain minor MUFAs and PUFAs of the gastric mucosa appear to be present in higher proportions in ulcer negative patients. Overall, the findings provide only weak evidence of an association between the gastric mucosal fatty acids and the presence of gastric ulceration. The higher average levels of EPA and DHA in abdominal and buttock adipose tissue in CLO negative controls could be an indicator that dietary FAs inhibit Helicobacter pylori growth. Larger studies are necessary to provide evidence of a biologically relevant effect.

Published
2009
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11. Lack of an association of depression with n-3 polyunsaturated fatty acids in adipose tissue and serum phospholipids in healthy adults.

Author

Mamalakis G, Kiriakakis M, Tsibinos G, Jansen E, Cremers H, Strien C, Hatzis C, Moschandreas J, Linardakis M, Kromhout D, and Kafatos A

Subjects
Adolescent, Adult, Aminolevulinic Acid metabolism, Anthropometry, Biomarkers, Body Mass Index, Cross-Sectional Studies, Depressive Disorder epidemiology, Female, Greece epidemiology, Humans, Linear Models, Male, Middle Aged, Psychiatric Status Rating Scales, Surveys and Questionnaires, Adipose Tissue metabolism, Depressive Disorder metabolism, Depressive Disorder psychology, Fatty Acids, Omega-3 metabolism, Phospholipids blood
Abstract

Studies have shown that depression relates to biomarkers of both short-term and long-term polyunsaturated fatty acid intake. However, it is not known which of these two biomarkers is more closely related to depression. The aim of this study was to examine the relationship of depression with both adipose tissue and serum phospholipid polyunsaturated fatty acids and to assess the importance of each of these two biomarkers in relating to depression. This is a cross-sectional study of healthy adults from the island of Crete. Subjects were examined by the Preventive Medicine and Nutrition Clinic of the University of Crete. Subjects were 394 healthy adults (175 males, 219 females) aged 18-60. The sample consisted of farmers from a number of rural communities of Crete. Fatty acids were determined by gas chromatography in adipose tissue and serum phospholipids. Information about depression was obtained through the Beck Depression Inventory (BDI) and Zung Self-rating Depression Scale (ZSRDS). Adipose tissue alpha-linolenic acid (ALA) (C18:3n-3) was inversely correlated to BDI (r=-0.17, p<0.02). Multiple linear regression analysis taking into account the possible confounding effect of age, gender, body mass index (BMI), smoking and educational level did not confirm this association. The other polyunsaturated fatty acids in adipose tissue were not related to depression. Serum phospholipid polyunsaturated fatty acids did not correlate with depression. This study did not show that the polyunsaturated fatty acids in the adipose tissue are better predictors of depression than those in serum phospholipids.

Published
2008
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12. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents.

Author

Mamalakis G, Kiriakakis M, Tsibinos G, Hatzis C, Flouri S, Mantzoros C, and Kafatos A

Subjects
Adolescent, Cytokines biosynthesis, Depression metabolism, Female, Humans, Linear Models, Male, Adiponectin blood, Adipose Tissue chemistry, Depression etiology, Fatty Acids, Omega-3 analysis, Fatty Acids, Omega-6 analysis
Abstract

The purpose of the present study was to investigate for a possible relationship between depression and serum adiponectin and adipose tissue omega-3 and omega-6 PUFA. The sample consisted of 90 healthy adolescent volunteers from the island of Crete. There were 54 girls and 36 boys, aged 13 to 18. The mean age was 15.2 years. Subjects were examined by the Preventive Medicine and Nutrition Clinic of the University of Crete. Depression was assessed through the use of the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D). Fatty acids were determined by gas chromatography in adipose tissue. CES-D correlated with dihomo-gamma linolenic acid (DGLA). Multiple linear regression analyses showed that BDI was negatively associated with eicosapentaenoic acid (EPA), while CES-D was positively associated with DGLA in adipose tissue. Serum adiponectin was not significantly associated with depression. The negative relationship between adipose EPA and depression in adolescents, is in line with findings of previous studies involving adult and elderly subjects, demonstrating negative relations between depression and adipose omega-3 PUFA. This is the first literature report of a relationship between depression and an individual omega-3 fatty acid in adolescents. The inverse relationship between adipose EPA and depression indicates that a low long-term dietary intake of EPA is associated with an increased risk for depression in adolescents.

Published
2006
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13. Depression and adipose polyunsaturated fatty acids in an adolescent group.

Author

Mamalakis G, Kiriakakis M, Tsibinos G, and Kafatos A

Subjects
Acetyltransferases metabolism, Adolescent, Fatty Acid Elongases, Fatty Acids, Omega-3 analysis, Fatty Acids, Omega-6 analysis, Female, Greece, Humans, Male, Adipose Tissue chemistry, Depression metabolism, Fatty Acids, Unsaturated analysis
Abstract

The purpose of the present study was to investigate the relation between adipose tissue polyunsaturated fatty acids, an index of long-term or habitual fatty acid dietary intake and depression. The sample consisted of 90 adolescents from the island of Crete. There were 54 girls and 36 boys, aged 13-18. The mean age was 15.2 years. Subjects were examined by the Preventive Medicine and Nutrition Clinic of the University of Crete. Depression was assessed through the use of the Beck Depression Inventory (BDI) and the Center for Epidemiologic Studies Depression Scale (CES-D). Unlike other studies, there were no significant relations between adipose tissue n-3 or n-6 polyunsaturated fatty acids and depression. BDI correlated positively with adipose tissue C20:3n-6/C18:3n-6 ratio, while CES-D correlated positively with adipose tissue (C20:3n-6+C22:5n-3)/(C18:3n-6+C20:5n-3) ratio. Depressed subjects (BDI>16, CES-D>16) had significantly elevated adipose tissue C20:3n-6/C18:3n-6 and (C20:3n-6+C22:5n-3)/(C18:3n-6+C20:5n-3) ratios, than non-depressed subjects. The observed positive relation between depression and the particular fatty acid ratios, in the present study, appears to indicate increasing activity of elongases, the enzymes responsible for elongating polyunsaturated fatty acids into their longer-chain derivatives, with increasing depression. This is the first literature report of a possible relation between elongases and depression. The observed relation may stem from a possible over-expression of the HELO1 (ELOVL5) gene, the gene encoding a protein responsible for elongating long-chain polyunsaturated fatty acids, in the adipose tissue of depressed adolescents.

Published
2004
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14. Depression and adipose polyunsaturated fatty acids in the survivors of the Seven Countries Study population of Crete.

Author

Mamalakis G, Kiriakakis M, Tsibinos G, and Kafatos A

Subjects
Adipose Tissue chemistry, Aged, Aged, 80 and over, Body Composition, Fatty Acids, Unsaturated administration & dosage, Fatty Acids, Unsaturated analysis, Greece, Humans, Male, Survival, Adipose Tissue metabolism, Depression metabolism, Fatty Acids, Unsaturated metabolism
Abstract

The purpose of the present study was to investigate the relation between adipose tissue polyunsaturated fatty acids, an index of long-term or habitual fatty acid dietary intake and depression. The sample consisted of 150 elderly males from the island of Crete. The subjects were survivors of the Greek Seven Countries Study group. The mean age was 84 years. The number of subjects with complete data on all variables studied was 63. Subjects were examined by the Preventive Medicine and Nutrition Clinic of the University of Crete. Depression was assessed through the use of the short form of the Geriatric Depression Scale (GDS-15). Depression correlated negatively with adipose tissue alpha-linolenic acid (C18:3n-3). Depressed subjects had significantly reduced (-10.5%) adipose tissue C18:3n-3 levels than non-depressed subjects. The observed negative relation between adipose tissue C18:3n-3 and depression, in the present study, appears to indicate increasing long-term dietary C18:3n-3 intakes with decreasing depression. This agrees with findings of other studies indicating an inverse relation between depression and consumption of fish and n-3 polyunsaturated fatty acids. This is the first literature report of a relation between adipose tissue C18:3n-3 and depression. Furthermore, this is the first report of a relation between adipose PUFA and depression in an elderly sample. Depression has been reported to be associated with elevated cytokines, such as, IL-1, IL-2, IL-6, INF-gamma and INF-alpha. Fish oil and omega-3 fatty acids, on the other hand, have been reported to inhibit cytokine production. The observed negative relation between adipose C18:3n-3 and depression, therefore, may stem from the inhibiting effect of C18:3n-3 or its long-chain metabolites on cytokine synthesis.

Published
2004
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