447 results on '"Kim, Young-Shin"'
Search Results
2. Efficacy of Community-Delivered PEERS® for Adolescents: Increases in Social Skills and Decreases in Social Anxiety and Loneliness
- Author
-
Parenteau, China I., Floyd, Jessica, Ankenman, Katy, Glavin, Tara, Charalel, Julia, Lin, Enjey, Ence, Whitney, Kim, Young Shin, Bishop, Somer, and Zheng, Shuting
- Published
- 2024
- Full Text
- View/download PDF
3. Neurodevelopmental profiles of 4-year-olds in the Navajo Birth Cohort Study.
- Author
-
Rennie, Brandon, Leventhal, Bennett, Park, Mina, Ghods, Sheila, Welch, Maria, MacKenzie, Debra, Lewis, Johnnye, Burnette, Courtney, Salzman, Emma, Nozadi, Sara, Kim, Hosanna, Geib, Ellen, Kim, Young Shin, Bishop, Somer, Ence, Whitney, and Zheng, Shuting
- Subjects
American Indian ,Native American ,indigenous ,language ,neurodevelopment - Abstract
OBJECTIVE: Native American children disproportionally face many risk factors for poor developmental outcomes; these factors include poverty, environmental toxicant exposure, and limited medical, and intervention services. To understand these risks, comprehensive documentation of developmental and behavioral phenotypes are needed. In the current descriptive study, we assessed the neurodevelopment of young Diné (Navajo) children using standardized assessment instruments in combination with expert clinician judgment. METHODS: As part of an ongoing, population-based, prospective birth cohort study, we conducted comprehensive neurodevelopmental assessments of 138, 3-5-year-old, Diné children residing on or near the Navajo Nation. We report results from standardized parent reports, psychiatric examinations, and direct assessments of childrens language, cognitive, adaptive, and social-emotional development, as well as best estimate clinical diagnoses. RESULTS: Forty-nine percent of our sample met DSM-5 criteria for a neurodevelopmental disorder (NDD) diagnosis. Language and speech sound disorders were most common, although autism spectrum disorder (ASD) was also elevated compared to the general population. Though language performance was depressed amongst all groups of children with, and without, NDDs, those meeting criteria for certain NDDs performed significantly lower on all language measures, when compared to those without. Social-emotional, behavioral, and nonverbal cognitive ability were in the average range overall. CONCLUSIONS: Diné children in our study were found to have a high percentage of clinically significant developmental delays. Overall, children presented with a pervasive pattern of depressed language performance across measures, irrespective of diagnosis (or no diagnosis), while other domains of functioning were similar to normative samples. Findings support the need to identify appropriate intervention and educational efforts for affected youth, while also exploring the causes of the specific developmental delays. However, longitudinal studies are necessary to establish best practices for identifying delays and delineating resilience factors to optimize development of Diné children.
- Published
- 2023
4. CRISIS AFAR: an international collaborative study of the impact of the COVID-19 pandemic on mental health and service access in youth with autism and neurodevelopmental conditions
- Author
-
Vibert, Bethany, Segura, Patricia, Gallagher, Louise, Georgiades, Stelios, Pervanidou, Panagiota, Thurm, Audrey, Alexander, Lindsay, Anagnostou, Evdokia, Aoki, Yuta, Birken, Catherine S, Bishop, Somer L, Boi, Jessica, Bravaccio, Carmela, Brentani, Helena, Canevini, Paola, Carta, Alessandra, Charach, Alice, Costantino, Antonella, Cost, Katherine T, Cravo, Elaine A, Crosbie, Jennifer, Davico, Chiara, Donno, Federica, Fujino, Junya, Gabellone, Alessandra, Geyer, Cristiane T, Hirota, Tomoya, Kanne, Stephen, Kawashima, Makiko, Kelley, Elizabeth, Kim, Hosanna, Kim, Young Shin, Kim, So Hyun, Korczak, Daphne J, Lai, Meng-Chuan, Margari, Lucia, Marzulli, Lucia, Masi, Gabriele, Mazzone, Luigi, McGrath, Jane, Monga, Suneeta, Morosini, Paola, Nakajima, Shinichiro, Narzisi, Antonio, Nicolson, Rob, Nikolaidis, Aki, Noda, Yoshihiro, Nowell, Kerri, Polizzi, Miriam, Portolese, Joana, Riccio, Maria Pia, Saito, Manabu, Schwartz, Ida, Simhal, Anish K, Siracusano, Martina, Sotgiu, Stefano, Stroud, Jacob, Sumiya, Fernando, Tachibana, Yoshiyuki, Takahashi, Nicole, Takahashi, Riina, Tamon, Hiroki, Tancredi, Raffaella, Vitiello, Benedetto, Zuddas, Alessandro, Leventhal, Bennett, Merikangas, Kathleen, Milham, Michael P, and Di Martino, Adriana
- Subjects
Biological Psychology ,Psychology ,Brain Disorders ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,Mental Health ,Autism ,Neurosciences ,Mental health ,Good Health and Well Being ,Female ,Humans ,Adolescent ,Child ,COVID-19 ,Autistic Disorder ,Pandemics ,Autism Spectrum Disorder ,Cross-Sectional Studies ,Mental health outcomes ,Autism spectrum disorder ,Neurodevelopmental conditions ,Sleep ,Behavioral problems ,Prediction ,Risk and resilience factors ,COVID-19 pandemic ,Public health ,Clinical Sciences ,Clinical sciences ,Biological psychology - Abstract
BackgroundHeterogeneous mental health outcomes during the COVID-19 pandemic are documented in the general population. Such heterogeneity has not been systematically assessed in youth with autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). To identify distinct patterns of the pandemic impact and their predictors in ASD/NDD youth, we focused on pandemic-related changes in symptoms and access to services.MethodsUsing a naturalistic observational design, we assessed parent responses on the Coronavirus Health and Impact Survey Initiative (CRISIS) Adapted For Autism and Related neurodevelopmental conditions (AFAR). Cross-sectional AFAR data were aggregated across 14 European and North American sites yielding a clinically well-characterized sample of N = 1275 individuals with ASD/NDD (age = 11.0 ± 3.6 years; n females = 277). To identify subgroups with differential outcomes, we applied hierarchical clustering across eleven variables measuring changes in symptoms and access to services. Then, random forest classification assessed the importance of socio-demographics, pre-pandemic service rates, clinical severity of ASD-associated symptoms, and COVID-19 pandemic experiences/environments in predicting the outcome subgroups.ResultsClustering revealed four subgroups. One subgroup-broad symptom worsening only (20%)-included youth with worsening across a range of symptoms but with service disruptions similar to the average of the aggregate sample. The other three subgroups were, relatively, clinically stable but differed in service access: primarily modified services (23%), primarily lost services (6%), and average services/symptom changes (53%). Distinct combinations of a set of pre-pandemic services, pandemic environment (e.g., COVID-19 new cases, restrictions), experiences (e.g., COVID-19 Worries), and age predicted each outcome subgroup.LimitationsNotable limitations of the study are its cross-sectional nature and focus on the first six months of the pandemic.ConclusionsConcomitantly assessing variation in changes of symptoms and service access during the first phase of the pandemic revealed differential outcome profiles in ASD/NDD youth. Subgroups were characterized by distinct prediction patterns across a set of pre- and pandemic-related experiences/contexts. Results may inform recovery efforts and preparedness in future crises; they also underscore the critical value of international data-sharing and collaborations to address the needs of those most vulnerable in times of crisis.
- Published
- 2023
5. Parent-Reported Suicidal Ideation in Three Population-Based Samples of School-Aged Korean Children With Autism Spectrum Disorder and Autism Spectrum Screening Questionnaire Screen Positivity
- Author
-
Bal, Vanessa H, Leventhal, Bennett L, Carter, Gregory, Kim, Hosanna, Koh, Yun-Joo, Ha, Mina, Kwon, Ho-Jang, Hong, Patricia, and Kim, Young Shin
- Subjects
Psychology ,Pediatric ,Brain Disorders ,Behavioral and Social Science ,Pediatric Research Initiative ,Mental Health ,Autism ,Intellectual and Developmental Disabilities (IDD) ,Depression ,Prevention ,Mental health ,Autism Spectrum Disorder ,Autistic Disorder ,Child ,Humans ,Mass Screening ,Republic of Korea ,Suicidal Ideation ,Anxiety ,ASD ,ASP ,epidemiological sample ,suicidality ,Health sciences - Abstract
ObjectivesHigher prevalence of suicidality has been reported in individuals with ASD. This study aimed to (1) Estimate the prevalence of suicidal ideation (SI) in epidemiologically-ascertained, population-based, samples of children with ASD or Autism Spectrum Screening Questionnaire (ASSQ) Screen Positivity (ASP); (2) Determine whether ASD/ASP is an independent risk factor for SI, controlling for known SI risk factors; and, (3) Develop an explanatory model for SI in children with ASD/ASP.MethodsParticipants came from three epidemiologically-ascertained samples of school-aged Korean children (n = 14,423; 3,702; 4,837). ASSQ ≥ 14 was the cutoff for ASP. A subsample (n = 86) was confirmed to have ASD. SI was based on parents' endorsement of items on the Behavioral Assessment System for Children-2-Parent Report Scale-Children. Logistic regressions were used to assess associations between SI and ASD/ASP, controlling for demographics, peer victimization, behavior problems, and depression. To develop an explanatory model for SI within ASD/ASP, the associations between SI and child characteristics (comorbid conditions, ASD symptoms, IQ, adaptive function) were tested.ResultsSI was higher in children with ASD (14%) and ASP (16.6-27.4%) than ASSQ Screen Negative (ASN) peers (3.4-6.9%). ASD/ASP was strongly predictive of SI (ORs: 2.87-5.67), after controlling for known SI risk factors compared to ASN. Within the ASD and ASP groups, anxiety was the strongest predictor of SI.ConclusionsSI prevalence was higher in non-clinical samples of children with ASD and ASP, relative to ASN peers. These results underscore the need for routine screening for SI in children with ASD and social difficulties, particularly those with high anxiety. HighlightsPopulation-based, epidemiologically-ascertained, school-aged childrenASD and ASP are independent risk factors for SI in school-aged childrenAnxiety is an independent risk factor for SI in children with ASD or ASP.
- Published
- 2022
6. Genome-Wide Association Study Points to Novel Locus for Gilles de la Tourette Syndrome
- Author
-
Barr, Cathy L., Batterson, James R., Berlin, Cheston, Budman, Cathy L., Coppola, Giovanni, Cox, Nancy J., Darrow, Sabrina, Dion, Yves, Freimer, Nelson B., Grados, Marco A., Greenberg, Erica, Hirschtritt, Matthew E., Huang, Alden Y., Illmann, Cornelia, King, Robert A., Kurlan, Roger, Leckman, James F., Lyon, Gholson J., Malaty, Irene A., McMahon, William M., Neale, Benjamin M., Okun, Michael S., Osiecki, Lisa, Robertson, Mary M., Rouleau, Guy A., Sandor, Paul, Singer, Harvey S., Smit, Jan H., Sul, Jae Hoon, Androutsos, Christos, Basha, Entela, Farkas, Luca, Fichna, Jakub, Janik, Piotr, Kapisyzi, Mira, Karagiannidis, Iordanis, Koumoula, Anastasia, Nagy, Peter, Puchala, Joanna, Szejko, Natalia, Szymanska, Urszula, Tsironi, Vaia, Apter, Alan, Ball, Juliane, Bodmer, Benjamin, Bognar, Emese, Buse, Judith, Vela, Marta Correa, Fremer, Carolin, Garcia-Delgar, Blanca, Gulisano, Mariangela, Hagen, Annelieke, Hagstrøm, Julie, Madruga-Garrido, Marcos, Pellico, Alessandra, Ruhrman, Daphna, Schnell, Jaana, Silvestri, Paola Rosaria, Skov, Liselotte, Steinberg, Tamar, Gloor, Friederike Tagwerker, Turner, Victoria L., Weidinger, Elif, Alexander, John, Aranyi, Tamas, Buisman, Wim R., Buitelaar, Jan K., Driessen, Nicole, Drineas, Petros, Fan, Siyan, Forde, Natalie J., Gerasch, Sarah, van den Heuvel, Odile A., Jespersgaard, Cathrine, Kanaan, Ahmad S., Möller, Harald E., Nawaz, Muhammad S., Nespoli, Ester, Pagliaroli, Luca, Poelmans, Geert, Pouwels, Petra J.W., Rizzo, Francesca, Veltman, Dick J., van der Werf, Ysbrand D., Widomska, Joanna, Zilhäo, Nuno R., Brown, Lawrence W., Cheon, Keun-Ah, Coffey, Barbara J., Fernandez, Thomas V., Gilbert, Donald L., Hong, Hyun Ju, Ibanez-Gomez, Laura, Kim, Eun-Joo, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett L., Maras, Athanasios, Murphy, Tara L., Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, State, Matthew W., Visscher, Frank, Wang, Sheng, Zinner, Samuel H., Tsetsos, Fotis, Topaloudi, Apostolia, Jain, Pritesh, Yang, Zhiyu, Yu, Dongmei, Kolovos, Petros, Tumer, Zeynep, Rizzo, Renata, Hartmann, Andreas, Depienne, Christel, Worbe, Yulia, Müller-Vahl, Kirsten R., Cath, Danielle C., Boomsma, Dorret I., Wolanczyk, Tomasz, Zekanowski, Cezary, Barta, Csaba, Nemoda, Zsofia, Tarnok, Zsanett, Padmanabhuni, Shanmukha S., Buxbaum, Joseph D., Grice, Dorothy, Glennon, Jeffrey, Stefansson, Hreinn, Hengerer, Bastian, Yannaki, Evangelia, Stamatoyannopoulos, John A., Benaroya-Milshtein, Noa, Cardona, Francesco, Hedderly, Tammy, Heyman, Isobel, Huyser, Chaim, Mir, Pablo, Morer, Astrid, Mueller, Norbert, Munchau, Alexander, Plessen, Kerstin J., Porcelli, Cesare, Roessner, Veit, Walitza, Susanne, Schrag, Anette, Martino, Davide, Tischfield, Jay A., Heiman, Gary A., Willsey, A. Jeremy, Dietrich, Andrea, Davis, Lea K., Crowley, James J., Mathews, Carol A., Scharf, Jeremiah M., Georgitsi, Marianthi, Hoekstra, Pieter J., and Paschou, Peristera
- Published
- 2024
- Full Text
- View/download PDF
7. Investigation of gene-environment interactions in relation to tic severity.
- Author
-
Abdulkadir, Mohamed, Yu, Dongmei, Osiecki, Lisa, King, Robert A, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hagstrøm, Julie, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett, Madruga-Garrido, Marcos, Maras, Athanasios, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Plessen, Kerstin J, Roessner, Veit, Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, Visscher, Frank, Zinner, Samuel H, Mathews, Carol A, Scharf, Jeremiah M, Tischfield, Jay A, Heiman, Gary A, Dietrich, Andrea, and Hoekstra, Pieter J
- Subjects
Humans ,Tourette Syndrome ,Tics ,Severity of Illness Index ,Attention Deficit Disorder with Hyperactivity ,Pregnancy ,Female ,Genome-Wide Association Study ,Gene-Environment Interaction ,Autism Spectrum Disorder ,Gene–environment interaction ,Pre- and perinatal complications ,Tic severity ,Tourette syndrome ,Mental Health ,Autism ,Genetics ,Pediatric ,Neurosciences ,Serious Mental Illness ,Brain Disorders ,Human Genome ,Neurodegenerative ,Intellectual and Developmental Disabilities (IDD) ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Gene-environment interaction ,Psychology ,Neurology & Neurosurgery - Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder with involvement of genetic and environmental factors. We investigated genetic loci previously implicated in Tourette syndrome and associated disorders in interaction with pre- and perinatal adversity in relation to tic severity using a case-only (N = 518) design. We assessed 98 single-nucleotide polymorphisms (SNPs) selected from (I) top SNPs from genome-wide association studies (GWASs) of TS; (II) top SNPs from GWASs of obsessive-compulsive disorder (OCD), attention-deficit/hyperactivity disorder (ADHD), and autism spectrum disorder (ASD); (III) SNPs previously implicated in candidate-gene studies of TS; (IV) SNPs previously implicated in OCD or ASD; and (V) tagging SNPs in neurotransmitter-related candidate genes. Linear regression models were used to examine the main effects of the SNPs on tic severity, and the interaction effect of these SNPs with a cumulative pre- and perinatal adversity score. Replication was sought for SNPs that met the threshold of significance (after correcting for multiple testing) in a replication sample (N = 678). One SNP (rs7123010), previously implicated in a TS meta-analysis, was significantly related to higher tic severity. We found a gene-environment interaction for rs6539267, another top TS GWAS SNP. These findings were not independently replicated. Our study highlights the future potential of TS GWAS top hits in gene-environment studies.
- Published
- 2021
8. Prenatal exposure to paternal smoking and likelihood for autism spectrum disorder
- Author
-
Kim, Bora, Ha, Mina, Kim, Young Shin, Koh, Yun-Joo, Dong, Shan, Kwon, Ho-Jang, Kim, Young-Suk, Lim, Myung-Ho, Paik, Ki-Chung, Yoo, Seung-Jin, Kim, Hosanna, Hong, Patricia S, Sanders, Stephan J, and Leventhal, Bennett L
- Subjects
Biomedical and Clinical Sciences ,Psychology ,Behavioral and Social Science ,Autism ,Pediatric ,Genetics ,Tobacco Smoke and Health ,Intellectual and Developmental Disabilities (IDD) ,Tobacco ,Mental Health ,Prevention ,Brain Disorders ,2.3 Psychological ,social and economic factors ,2.1 Biological and endogenous factors ,Aetiology ,Reproductive health and childbirth ,Mental health ,Autism Spectrum Disorder ,Causality ,Family ,Female ,Humans ,Pregnancy ,Prenatal Exposure Delayed Effects ,Risk Factors ,Smoking ,autism spectrum disorders ,environmental factors ,risk factor epidemiology ,Specialist Studies in Education ,Cognitive Sciences ,Developmental & Child Psychology ,Biomedical and clinical sciences - Abstract
Lay abstractWhat is Already Known about This Subject: Genetics, (including de novo mutations), environmental factors (including toxic exposures), and their interactions impact autism spectrum disorder etiology. Paternal smoking is a candidate risk for autism spectrum disorder due to biological plausibility, high prevalence, and potential intervention.What This Study Adds: This original study and its replication confirms that paternal factors can substantially contribute to autism spectrum disorder risk for their offspring. It specifically indicates that paternal smoking both before and during pregnancy contributes significantly to autism spectrum disorder risk.Implications for practice, research, or policy: Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring.
- Published
- 2021
9. Analyzing the stress characteristics of glass as a function of cooling rate when applying air and mist for rapid cooling of glass heated to high temperatures
- Author
-
Kim, Young Shin and Jeon, Euy Sik
- Published
- 2023
- Full Text
- View/download PDF
10. Effects of surface treatment method and fabric type on adhesion between PP material and artificial fabrics
- Author
-
Kim, Young Shin and Jeon, Euy Sik
- Published
- 2023
- Full Text
- View/download PDF
11. Neurodevelopmental Profiles of 4-Year-Olds in the Navajo Birth Cohort Study
- Author
-
Rennie, Brandon J., Bishop, Somer, Leventhal, Bennett L., Zheng, Shuting, Geib, Ellen F., Kim, Young Shin, Burnette, Courtney, Salzman, Emma, Nozadi, Sara S., Kim, Hosanna, Ence, Whitney, Park, Mina, Ghods, Sheila, Welch, Maria L., MacKenzie, Debra, and Lewis, Johnnye
- Published
- 2023
- Full Text
- View/download PDF
12. Sex differences in scores on standardized measures of autism symptoms: a multisite integrative data analysis.
- Author
-
Kaat, Aaron J, Shui, Amy M, Ghods, Sheila S, Farmer, Cristan A, Esler, Amy N, Thurm, Audrey, Georgiades, Stelios, Kanne, Stephen M, Lord, Catherine, Kim, Young Shin, and Bishop, Somer L
- Subjects
Humans ,Autistic Disorder ,Sex Characteristics ,Adolescent ,Adult ,Child ,Child ,Preschool ,Female ,Male ,Autism Spectrum Disorder ,Data Analysis ,Sex differences ,autism spectrum disorder ,restricted and repetitive behavior ,social impairment ,Pediatric ,Autism ,Mental Health ,Clinical Research ,Brain Disorders ,Intellectual and Developmental Disabilities (IDD) ,Mental health ,Clinical Sciences ,Psychology ,Cognitive Sciences ,Developmental & Child Psychology - Abstract
BackgroundConcerns have been raised that scores on standard measures of autism spectrum disorder (ASD) symptoms may differ as a function of sex. However, these findings are hindered by small female samples studied thus far. The current study evaluated if, after accounting for age, IQ, and language level, sex affects ASD severity estimates from diagnostic measures among children with ASD.MethodsData were obtained from eight sources comprising 27 sites. Linear mixed-effects models, including a random effect for site, were fit for 10 outcomes (Autism Diagnostic Observation Schedule [ADOS] domain-level calibrated severity scores, Autism Diagnostic Interview-Revised [ADI-R] raw scores by age-based algorithm, and raw scores from the two indices on the Social Responsiveness Scale [SRS]). Sex was added to the models after controlling for age, NVIQ, and an indicator for language level.ResultsSex significantly improved model fit for half of the outcomes, but least square mean differences were generally negligible (effect sizes [ES]
- Published
- 2021
13. Prevalence and cumulative incidence of autism spectrum disorders and the patterns of co-occurring neurodevelopmental disorders in a total population sample of 5-year-old children
- Author
-
Saito, Manabu, Hirota, Tomoya, Sakamoto, Yui, Adachi, Masaki, Takahashi, Michio, Osato-Kaneda, Ayako, Kim, Young Shin, Leventhal, Bennett, Shui, Amy, Kato, Sumi, and Nakamura, Kazuhiko
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Intellectual and Developmental Disabilities (IDD) ,Pediatric Research Initiative ,Mental Health ,Pediatric ,Clinical Research ,Brain Disorders ,Autism ,Aetiology ,2.4 Surveillance and distribution ,Mental health ,Autism Spectrum Disorder ,Child ,Preschool ,Comorbidity ,Cross-Sectional Studies ,Female ,Humans ,Incidence ,Infant ,Japan ,Male ,Neurodevelopmental Disorders ,Population Surveillance ,Prevalence ,Risk Assessment ,Risk Factors ,Socioeconomic Factors ,Cumulative incidence ,Co-existing neurodevelopmental disorders ,Autism spectrum disorder ,A total population study ,a total population sample ,prevalence ,cumulative incidence ,Neurosciences ,Clinical sciences ,Biological psychology - Abstract
BackgroundsWhether there is a true increase in autism spectrum disorder (ASD) frequency or not remains unclear. Additionally, the rates of co-existing neurodevelopmental disorders (NDD) in a total population sample has not been fully examined before. Therefore, using a total population sample in Japan, we aimed to estimate the prevalence and cumulative incidence of autism spectrum disorder (ASD) annually, to determine whether there is a true increase in ASD prevalence by estimating the cumulative incidence of ASD annually, and to examine the rates of co-existing neurodevelopmental disorders (NDD).MethodIn this cross-sectional sequential design study, all 5-year-old children in the catchment area underwent the screening annually from the year 2013-2016. Screen-positive children were invited to participate in a comprehensive assessment, including child and parent interview, behavioral observation, and cognitive and motor function testing. All cases were reviewed by a multidisciplinary research team.ResultsCaregivers of 3954 children returned the screening, among which 559 children underwent the assessment with 87 children receiving an ASD diagnosis. Adjusted ASD prevalence was 3.22% (95% confidence interval (CI) 2.66-3.76%). The male to female ratio of the crude prevalence was 2.2:1. The cumulative incidence of ASD up to 5 years of age for the total study years was 1.31% (95% CI 1.00-1.62%). A generalized linear model revealed no significant linear trends in 5-year cumulative incidence over the study years. Only 11.5% of children had ASD alone; the remaining 88.5% were found to have at least one co-existing NDD.LimitationsModest sample size for a total population study.ConclusionsOur findings demonstrate the stability of the 5-year cumulative incidence of ASD, implying no true rise in ASD incident cases over the 4-year study period in the study catchment area. High rates of co-existing NDDs reflect the importance of investigating broad developmental challenges in children with ASD.
- Published
- 2020
14. Latent and controllable doping of stimuli-activated molecular dopants for flexible and printable organic thermoelectric generators
- Author
-
Kim, Young-Shin, Kim, Hoimin, Yoon, Taewoong, Kim, Min-Jae, Lee, Jiyun, Lee, Hansol, Lee, Dongki, Song, Young Jae, Kwon, Jimin, Jo, Sae Byeok, Cho, Jeong Ho, Lee, Seung Goo, and Kang, Boseok
- Published
- 2023
- Full Text
- View/download PDF
15. Familial Risk of Gout and Interaction With Obesity and Alcohol Consumption: A Population‐Based Cohort Study in Korea
- Author
-
Kim, Kyoung‐Hoon, Choi, In Ah, Kim, Hyun Jung, Swan, Heather, Kazmi, Sayada Zartasha, Hong, Gahwi, Kim, Young Shin, Choi, Seeun, Kang, Taeuk, Cha, Jaewoo, Eom, Jungmin, Kim, Kyeong Uoon, Hann, Hoo Jae, and Ahn, Hyeong Sik
- Published
- 2023
- Full Text
- View/download PDF
16. Boosting thermoelectric performance of conjugated polymers via interchain molecular docking: Significance of highly crystalline and percolated morphology
- Author
-
Lee, Hansol, Lee, Su Bin, Kim, Young-Shin, Kim, Hoimin, Kim, Min-Jae, Yoon, Tae Woong, Lee, Dongki, Cho, Jeong Ho, Kim, Yun-Hi, and Kang, Boseok
- Published
- 2023
- Full Text
- View/download PDF
17. Prevalence of and Factors Associated with School Bullying in Students with Autism Spectrum Disorder: A Cross-Cultural Meta-Analysis.
- Author
-
Park, Inhwan, Gong, Jared, Lyons, Gregory L, Hirota, Tomoya, Takahashi, Michio, Kim, Bora, Lee, Seung Yeon, Kim, Young Shin, Lee, Jeongsoo, and Leventhal, Bennett L
- Subjects
Humans ,Prevalence ,Interpersonal Relations ,Cross-Cultural Comparison ,Students ,Adolescent ,Child ,Child ,Preschool ,Crime Victims ,Female ,Male ,Young Adult ,Bullying ,Autism Spectrum Disorder ,Students with ASD ,associated factors ,bullying ,cultural difference ,methodological quality ,prevalence ,Preschool ,General & Internal Medicine ,Medical and Health Sciences - Abstract
Through this meta-analysis, we sought to examine the prevalence of, risks for, and factors associated with bullying involvement (victimization, perpetration, perpetration-victimization) among students with autism spectrum disorder (ASD). Additionally, we attempted to examine sources of variance in the prevalence and effect sizes of bullying in students with ASD across studies. Systematic database and literature review identified 34 relevant studies (31 for Western countries, three for Eastern countries). Pooled prevalence estimates for victimization, perpetration, and perpetration-victimization in general were 67%, 29%, and 14%, respectively. The risk of victimization in students with ASD was significantly higher than that in typically developing students and students with other disabilities. Further, deficits in social interaction and communication, externalizing symptoms, internalizing symptoms, and integrated inclusive school settings were related to higher victimization, and externalizing symptoms were related to higher perpetration. Finally, moderation analyses revealed significant variations in the pooled prevalences thereof depending on culture, age, school settings, and methodological quality and in the pooled effect sizes according to publication year and methodological quality. Our results highlight needs for bullying intervention for students with ASD, especially those who are younger, are in an inclusive school setting, and have higher social difficulties and externalizing/internalizing symptoms; for intensive research of bullying experiences among students with ASD in Eastern countries; and for efforts to improve the methodological quality of such research.
- Published
- 2020
18. Prenatal Exposure to Paternal Smoking and Likelihood for Autism Spectrum Disorder
- Author
-
Kim, Bora, Ha, Mina, Kim, Young Shin, Koh, Yun-Joo, Dong, Shan, Kwon, Ho-Jang, Kim, Young-Suk, Lim, Myung-Ho, Paik, Ki-Chung, Yoo, Seung-Jin, Kim, Hosanna, Hong, Patricia S., Sanders, Stephan J., and Leventhal, Bennett L.
- Abstract
Genetics, environment, and their interactions impact autism spectrum disorder etiology. Smoking is a suspected autism spectrum disorder risk factor due to biological plausibility and high prevalence. Using two large epidemiological samples, we examined whether autism spectrum disorder was associated with prenatal paternal smoking in a Discovery sample (N = 10,245) and an independent Replication sample (N = 29,773). Paternal smoking was retrospectively assessed with questionnaires. Likelihood of having autism spectrum disorder was estimated with the Autism Spectrum Screening Questionnaire at three levels: low (<10), intermediate (10-14), and high ([greater than or equal to]15). Ordinal regression was used to examine the relationship between prenatal paternal smoking and likelihood of having autism spectrum disorder, adjusting for confounders. A total of 36.5% of Discovery sample fathers and 63.3% of Replication sample fathers smoked during the pregnancy period; 7% of the Replication sample smoker fathers smoked during the pre-conception period but quit during pregnancy period. Discovery sample prenatal paternal smoking significantly increased the likelihood of having autism spectrum disorder in their offspring (adjusted odds ratio=1.27). This was confirmed in the Replication sample with adjusted odds ratio of 1.15 among smoking pre-conception period + pregnancy period fathers; 14.4% and 11.1% increased high likelihood of autism spectrum disorder was attributable to prenatal paternal smoking in Discovery sample and Replication sample, respectively. Smoking prevention, especially in pregnancy planning, may decrease autism spectrum disorder risk in offspring.
- Published
- 2021
- Full Text
- View/download PDF
19. Adaptation of autism spectrum screening questionnaire (ASSQ) for use in Georgian school settings
- Author
-
Zirakashvili, Medea, Gabunia, Maia, Mebonia, Nana, Mikiashvili, Tamar, Lomidze, Giorgi, Bishop, Somer, Leventhal, Bennett, and Kim, Young Shin
- Published
- 2022
- Full Text
- View/download PDF
20. Portfolio optimization and marginal contribution to risk on multivariate normal tempered stable model
- Author
-
Kim, Young Shin
- Published
- 2022
- Full Text
- View/download PDF
21. Child mortality of twins and singletons among late preterm and term birth: a study of national linked birth and under-five mortality data of Korea
- Author
-
Kim, Young Shin, Kang, Minku, Choe, Young June, Sung, Joohon, Lee, Ji Yeon, and Choe, Seung-Ah
- Published
- 2022
- Full Text
- View/download PDF
22. Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder
- Author
-
An, Joon-Yong, Lin, Kevin, Zhu, Lingxue, Werling, Donna M, Dong, Shan, Brand, Harrison, Wang, Harold Z, Zhao, Xuefang, Schwartz, Grace B, Collins, Ryan L, Currall, Benjamin B, Dastmalchi, Claudia, Dea, Jeanselle, Duhn, Clif, Gilson, Michael C, Klei, Lambertus, Liang, Lindsay, Markenscoff-Papadimitriou, Eirene, Pochareddy, Sirisha, Ahituv, Nadav, Buxbaum, Joseph D, Coon, Hilary, Daly, Mark J, Kim, Young Shin, Marth, Gabor T, Neale, Benjamin M, Quinlan, Aaron R, Rubenstein, John L, Sestan, Nenad, State, Matthew W, Willsey, A Jeremy, Talkowski, Michael E, Devlin, Bernie, Roeder, Kathryn, and Sanders, Stephan J
- Subjects
Human Genome ,Genetics ,Biotechnology ,Intellectual and Developmental Disabilities (IDD) ,Mental Health ,Brain Disorders ,Autism ,Pediatric ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Autism Spectrum Disorder ,Binding Sites ,Conserved Sequence ,DNA Mutational Analysis ,Genetic Loci ,Genetic Variation ,Humans ,Mutation ,Pedigree ,Promoter Regions ,Genetic ,Risk ,Transcription Factors ,General Science & Technology - Abstract
Whole-genome sequencing (WGS) has facilitated the first genome-wide evaluations of the contribution of de novo noncoding mutations to complex disorders. Using WGS, we identified 255,106 de novo mutations among sample genomes from members of 1902 quartet families in which one child, but not a sibling or their parents, was affected by autism spectrum disorder (ASD). In contrast to coding mutations, no noncoding functional annotation category, analyzed in isolation, was significantly associated with ASD. Casting noncoding variation in the context of a de novo risk score across multiple annotation categories, however, did demonstrate association with mutations localized to promoter regions. We found that the strongest driver of this promoter signal emanates from evolutionarily conserved transcription factor binding sites distal to the transcription start site. These data suggest that de novo mutations in promoter regions, characterized by evolutionary and functional signatures, contribute to ASD.
- Published
- 2018
23. Cryptocurrency portfolio optimization with multivariate normal tempered stable processes and Foster-Hart risk
- Author
-
Kurosaki, Tetsuo and Kim, Young Shin
- Published
- 2022
- Full Text
- View/download PDF
24. Aumann–Serrano index of risk in portfolio optimization
- Author
-
Li, Tiantian, Kim, Young Shin, Fan, Qi, and Zhu, Fumin
- Published
- 2021
- Full Text
- View/download PDF
25. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach
- Author
-
Abdulkadir, Mohamed, Londono, Douglas, Gordon, Derek, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, Elzerman, Lonneke, Fremer, Carolin, Fründt, Odette, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Jakubovski, Ewgeni, Kim, Young Key, Kim, Young Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Mir, Pablo, Morer, Astrid, Müller-Vahl, Kirsten, Münchau, Alexander, Murphy, Tara L, Plessen, Kerstin J, Roessner, Veit, Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, King, Robert A, Tischfield, Jay A, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea
- Subjects
Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Brain Disorders ,Autism ,Genetics ,Pediatric ,Mental Health ,Intellectual and Developmental Disabilities (IDD) ,Tourette Syndrome ,Neurodegenerative ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Adolescent ,Adult ,Child ,Child ,Preschool ,Family Health ,Female ,Genome-Wide Association Study ,Genotype ,Humans ,Linkage Disequilibrium ,Male ,Microtubule-Associated Proteins ,Middle Aged ,Polymorphism ,Single Nucleotide ,Severity of Illness Index ,Tic Disorders ,Tryptophan Hydroxylase ,Young Adult ,Attention-deficit/hyperactivity disorder ,Candidate gene study ,Obsessive-compulsive disorder ,Tourette syndrome ,Transmission Disequilibrium Test ,Obsessive–compulsive disorder ,Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology - Abstract
Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case-control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive-compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were tagging SNPs from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top SNPs from TS GWAS; and 13 top SNPs from attention-deficit/hyperactivity disorder, OCD, or ASD GWAS. None of the SNPs or genes reached significance after adjustment for multiple testing. We observed nominal significance for the candidate SNPs rs3744161 (TBCD) and rs4565946 (TPH2) and for five tagging SNPs; none of these showed significance in the independent cohort. Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM). We found no convincing support for previously implicated genetic polymorphisms. Targeted re-sequencing should fully appreciate the relevance of candidate genes.
- Published
- 2018
26. Autism Spectrum Disorder and School Bullying: Who is the Victim? Who is the Perpetrator?
- Author
-
Hwang, Soonjo, Kim, Young Shin, Koh, Yun-Joo, and Leventhal, Bennett L
- Subjects
Prevention ,Violence Research ,Brain Disorders ,Mental Health ,Pediatric Research Initiative ,Youth Violence ,Intellectual and Developmental Disabilities (IDD) ,Youth Violence Prevention ,Behavioral and Social Science ,Physical Injury - Accidents and Adverse Effects ,Pediatric ,Autism ,2.3 Psychological ,social and economic factors ,Aetiology ,Mental health ,Autism Spectrum Disorder ,Bullying ,Child ,Comorbidity ,Crime Victims ,Cross-Sectional Studies ,Female ,Humans ,Longitudinal Studies ,Male ,Schools ,Students ,School bullying ,Autism spectrum disorder ,DSM-5 ,Comorbid psychopathology ,Autism diagnostic observation scale and autism diagnostic interview ,Behavior assessment system for children ,Education ,Psychology and Cognitive Sciences ,Developmental & Child Psychology - Abstract
While a growing number of studies indicate associations between experiences of bullying and autism spectrum disorder (ASD), it is not clear what roles comorbid behavioral problems may play. We investigated the experiences of children with ASD as victims and/or perpetrators of bullying. Children with ASD epidemiologically ascertained participated in a cross-sectional study. Although children with ASD showed significantly increased risk for bullying involvement compared to community children, after controlling for comorbid psychopathology and other demographic factors, increased risks for being perpetrators or victim-perpetrators disappeared while risk for being bullied/teased continued to be significantly elevated. This finding will help guide medical, educational and community personnel to effectively identify children with ASD at risk for school bullying and develop interventions.
- Published
- 2018
27. Discrepancy in perception of bullying experiences and later internalizing and externalizing behavior: A prospective study.
- Author
-
Hwang, Soonjo, Kim, Young Shin, Koh, Yun-Joo, Bishop, Somer, and Leventhal, Bennett L
- Subjects
Humans ,Risk Factors ,Follow-Up Studies ,Prospective Studies ,Aggression ,Depression ,Defense Mechanisms ,Dental Anxiety ,Peer Group ,Adolescent ,Child ,Crime Victims ,Female ,Male ,Self Report ,Bullying ,adolescence ,bullying ,discrepancy in the perception of bullying experiences ,internalizing/externalizing behavior ,internalizing ,externalizing behavior ,Pediatric ,Clinical Research ,Mental Health ,Behavioral and Social Science ,Youth Violence ,Violence Research ,Criminology ,Psychology ,Developmental & Child Psychology - Abstract
Discrepancy in perception of bullying experiences may lead to later internalizing or externalizing behavior in adolescents. A 1,663 South Korean 7th and 8th graders (mean age: 13.1 and 14.1 years old), were seen for a follow-up study to examine the relationships between the discrepancy in perception of their bullying experiences (defined as discrepancy between self- and peer-reports of bullying experiences) and internalizing or externalizing behavior at follow-up. Bullying was assessed by self- and peer-report. The discrepancy in perception of bullying experiences was defined by the concordance or discordance between self- and peer-reports. Internalizing and externalizing behavior was evaluated using the Youth Self Report and Child Behavior Checklist, at baseline and follow-up. Two by two ANCOVA was performed with a factorial design, categorizing discrepancy in perception of bullying experiences based on the agreement between self-report and peer-report. Internalizing/externalizing behavior-at-follow-up was used as an outcome, adjusting for other known risk factors for internalizing/externalizing behavior, including baseline internalizing/externalizing behavior, and bullying experiences. Adolescents with perceptions of bullying experiences discrepant from peer-reports showed increased internalizing/externalizing behavior at follow-up. Bullying also stands out as an independent risk factor for the development of future externalizing behavior even among adolescents with accurate perceptions of bullying experiences. These specific groups of youth warrant more focused assessment and intervention.
- Published
- 2017
28. Cross-Cultural Aspect of Behavior Assessment System for Children-2, Parent Rating Scale-Child: Standardization in Korean Children.
- Author
-
Kim, Young Shin, Song, J, Leventhal, BL, Koh, YJ, Cheon, KA, Hong, HJ, Kim, YK, Cho, K, Lim, EC, Park, JI, and Kim, YS
- Abstract
Our study aimed to examine psychometric properties and cross-cultural utility of the Behavior Assessment System for Children-2, Parent Rating Scale-Child (BASC-2 PRS-C) in Korean children.Two study populations were recruited: a general population sample (n
- Published
- 2017
29. Often Asked but Rarely Answered: Can Asians Meet DSM-5/ICD-10 Autism Spectrum Disorder Criteria?
- Author
-
Kim, So Hyun, Kim, Young Shin, Koh, Yun-Joo, Lim, Eun-Chung, Kim, Soo-Jeong, and Leventhal, Bennett L
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Clinical Research ,Behavioral and Social Science ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Mental Health ,Autism ,Mental health ,Adolescent ,Asian People ,Autism Spectrum Disorder ,Child ,Diagnostic and Statistical Manual of Mental Disorders ,Factor Analysis ,Statistical ,Female ,Humans ,International Classification of Diseases ,Male ,Phenotype ,Republic of Korea ,Sensitivity and Specificity ,Social Behavior ,autism spectrum disorder ,diagnostic assessment ,cross-cultural application ,Developmental & Child Psychology ,Pharmacology and pharmaceutical sciences - Abstract
ObjectivesTo evaluate whether Asian (Korean children) populations can be validly diagnosed with autism spectrum disorder (ASD) using Western-based diagnostic instruments and criteria based on Diagnostic and Statistical Manual on Mental Disorders, 5th edition (DSM-5).MethodsParticipants included an epidemiologically ascertained 7-14-year-old (N = 292) South Korean cohort from a larger prevalence study (N = 55,266). Main outcomes were based on Western-based diagnostic methods for Korean children using gold standard instruments, Autism Diagnostic Interview-Revised, and Autism Diagnostic Observation Schedule. Factor analysis and ANOVAs were performed to examine factor structure of autism symptoms and identify phenotypic differences between Korean children with ASD and non-ASD diagnoses.ResultsUsing Western-based diagnostic methods, Korean children with ASD were successfully identified with moderate-to-high diagnostic validity (sensitivities/specificities ranging 64%-93%), strong internal consistency, and convergent/concurrent validity. The patterns of autism phenotypes in a Korean population were similar to those observed in a Western population with two symptom domains (social communication and restricted and repetitive behavior factors). Statistically significant differences in the use of socially acceptable communicative behaviors (e.g., direct gaze, range of facial expressions) emerged between ASD versus non-ASD cases (mostly p
- Published
- 2016
30. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder
- Author
-
Abdulkadir, Mohamed, Tischfield, Jay A, King, Robert A, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, de Bruijn, Sebastian FTM, Elzerman, Lonneke, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hagstrøm, Julie, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Lamerz, Andreas, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Messchendorp, Marieke D, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Murphy, Tara L, Openneer, Thaïra JC, Plessen, Kerstin J, Rath, Judith JG, Roessner, Veit, Fründt, Odette, Shin, Eun-Young, Sival, Deborah A, Song, Dong-Ho, Song, Jungeun, Stolte, Anne-Marie, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, State, Matthew W, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea
- Subjects
Clinical and Health Psychology ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Tourette Syndrome ,Neurosciences ,Neurodegenerative ,Pediatric ,Clinical Research ,Attention Deficit Hyperactivity Disorder (ADHD) ,Infant Mortality ,Serious Mental Illness ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Good Health and Well Being ,Adolescent ,Adult ,Age Factors ,Aged ,Aged ,80 and over ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Child ,Child ,Preschool ,Europe ,Female ,Humans ,Male ,Middle Aged ,Obsessive-Compulsive Disorder ,Parent-Child Relations ,Pregnancy ,Pregnancy Complications ,Psychiatric Status Rating Scales ,Republic of Korea ,Retrospective Studies ,Severity of Illness Index ,Sex Factors ,Tic Disorders ,United States ,Young Adult ,Attention-deficit hyperactivity disorder ,Delivery ,Obsessive-compulsive disorder ,Prenatal ,Tourette syndrome ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.
- Published
- 2016
31. The social responsiveness scale in relation to DSM IV and DSM5 ASD in Korean children
- Author
-
Cheon, Keun‐Ah, Park, Jee‐In, Koh, Yun‐Joo, Song, Jungeun, Hong, Hyun‐Joo, Kim, Young‐Kee, Lim, Eun‐Chung, Kwon, Hojang, Ha, Mina, Lim, Myung‐Ho, Paik, Ki‐Chung, Constantino, John N, Leventhal, Bennett, and Kim, Young Shin
- Subjects
Biomedical and Clinical Sciences ,Applied and Developmental Psychology ,Clinical and Health Psychology ,Neurosciences ,Psychology ,Intellectual and Developmental Disabilities (IDD) ,Mental Health ,Clinical Research ,Pediatric ,Behavioral and Social Science ,Brain Disorders ,Autism ,Mental health ,Autism Spectrum Disorder ,Child ,Child Development Disorders ,Pervasive ,Cross-Cultural Comparison ,Diagnosis ,Differential ,Diagnostic and Statistical Manual of Mental Disorders ,Female ,Humans ,Male ,Mass Screening ,Psychometrics ,Reproducibility of Results ,Republic of Korea ,Social Communication Disorder ,Korean social responsiveness scale ,validity ,reliability ,DSM IV PDD ,DSM5 ASD ,Clinical Sciences ,Developmental & Child Psychology ,Applied and developmental psychology ,Clinical and health psychology - Abstract
The Social Responsiveness Scale (SRS) is an autism rating scales in widespread use, with over 20 official foreign language translations. It has proven highly feasible for quantitative ascertainment of autistic social impairment in public health settings, however, little is known about the validity of the reinforcement in Asia populations or in references to DSM5. The current study aims to evaluate psychometric properties and cross-cultural aspects of the SRS-Korean version (K-SRS).The study subjects were ascertained from three samples: a general sample from 3 regular education elementary schools (n=790), a clinical sample (n=154) of 6-12-year-olds from four psychiatric clinics, and an epidemiological sample of children with ASD, diagnosed using both DSM IV PDD, DSM5 ASD and SCD criteria (n=151). Their parents completed the K-SRS and the Autism Spectrum Screening Questionnaire(ASSQ). Descriptive statistics, correlation analyses and principal components analysis (PCA) were performed on the total population. Mean total scores on the K-SRS differed significantly between the three samples. ASSQ scores were significantly correlated with the K-SRS T-scores. PCA suggested a one-factor solution for the total population.Our results indicate that the K-SRS exhibits adequate reliability and validity for measuring ASD symptoms in Korean children with DSM IV PDD and DSM5 ASD. Our findings further suggest that it is difficult to distinguish SCD from other child psychiatric conditions using the K-SRS.This is the first study to examine the relationship between the SRS subscales and DSM5-based clinical diagnoses. This study provides cross-cultural confirmation of the factor structure for ASD symptoms and traits measured by the SRS. Autism Res 2016, 9: 970-980. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.
- Published
- 2016
32. Differences in the severity and variability of restricted and repetitive behaviors in ASD children with and without service experiences
- Author
-
Park, Ju Hee, Kim, Young-Shin, Koh, Yun-Joo, and Leventhal, Bennett L.
- Published
- 2020
- Full Text
- View/download PDF
33. Childhood vaccination as a protective factor for developmental psychopathology
- Author
-
Kim, Bora, Ha, Mina, Kim, Young Shin, Koh, Yun-Joo, Kwon, Ho-Jang, Lim, Myung-Ho, Paik, Ki-Chung, Kim, Hosanna, Hong, Patricia, and Leventhal, Bennett L.
- Published
- 2020
- Full Text
- View/download PDF
34. Effect of flame‐retardant melamine and dispersants on the mechanical, thermal, and foaming properties of flexible polyurethane foam.
- Author
-
Jeon, Yu Yeong, Jeon, Euy Sik, and Kim, Young Shin
- Subjects
FOAM ,URETHANE foam ,DISPERSING agents ,MELAMINE ,FIREPROOFING ,FIREPROOFING agents ,MOLECULAR weights - Abstract
The objective of this study was to investigate the effect of adding flame‐retardant melamine and five different dispersants on the precipitation, foaming, mechanical, and thermal properties of flexible polyurethane foam (FPUF). Precipitation experiments were conducted to analyze the effect of dispersant on the separation of flame retardant and polyol, and the foaming characteristics of polyurethane (PU) foam after adding dispersant were analyzed. The effect of adding a dispersant on mechanical strength was characterized by measuring tensile strength, tearing strength, and hardness, and scanning electron microscopy analysis was performed to analyze morphological characteristics. Thermogravimetric analysis (TGA) was performed to analyze the thermal properties of PU foam. A horizontal flame test, limiting oxygen index test, and cone calorimeter tests were conducted to examine the flame retardancy of PU foam with flame retardant melamine and dispersant added. The dispersant ANTI‐TERRA‐U is a solution of a salt of unsaturated polyamine amides and low‐molecular acidic polyesters. And, the dispersant BYK‐220S is a solution of a low molecular weight, unsaturated acidic polycarboxylic acid polyester with a polysiloxane copolymer. The dispersants ANTI‐TERRA‐U and BYK‐220S improved the density, tensile strength, tear strength, and hardness of FPUF. TGA of the top and bottom portions of the foam showed less weight difference for samples containing dispersants, indicating better homogeneity due to improved dispersibility. Therefore, we conclude that dispersants are beneficial additives to improve the mechanical properties and dispersibility of PU foam. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. In Utero Exposure to Maternal COVID-19 Vaccination and Offspring Neurodevelopment at 12 and 18 Months.
- Author
-
Jaswa, Eleni G., Cedars, Marcelle I., Lindquist, Karla J., Bishop, Somer L., Kim, Young-Shin, Kaing, Amy, Prahl, Mary, Gaw, Stephanie L., Corley, Jamie, Hoskin, Elena, Cho, Yoon Jae, Rogers, Elizabeth, and Huddleston, Heather G.
- Published
- 2024
- Full Text
- View/download PDF
36. A New Stochastic Process with Long-Range Dependence
- Author
-
Kim, Sung Ik and Kim, Young Shin
- Published
- 2020
- Full Text
- View/download PDF
37. Genetic Epidemiology and Insights into Interactive Genetic and Environmental Effects in Autism Spectrum Disorders
- Author
-
Kim, Young Shin and Leventhal, Bennett L
- Subjects
Biological Sciences ,Genetics ,Prevention ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Mental Health ,Pediatric ,Autism ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Child Development Disorders ,Pervasive ,Gene-Environment Interaction ,Humans ,Molecular Epidemiology ,Twin Studies as Topic ,Autism spectrum disorders ,Environment ,Genes ,Genetic epidemiology ,Interactions ,Neurodevelopmental disorders ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Biological sciences ,Biomedical and clinical sciences ,Psychology - Abstract
Understanding the pathogenesis of neurodevelopmental disorders has proven to be challenging. Using autism spectrum disorder (ASD) as a paradigmatic neurodevelopmental disorder, this article reviews the existing literature on the etiological substrates of ASD and explores how genetic epidemiology approaches including gene-environment interactions (G×E) can play a role in identifying factors associated with ASD etiology. New genetic and bioinformatics strategies have yielded important clues to ASD genetic substrates. The next steps for understanding ASD pathogenesis require significant effort to focus on how genes and environment interact with one another in typical development and its perturbations. Along with larger sample sizes, future study designs should include sample ascertainment that is epidemiologic and population-based to capture the entire ASD spectrum with both categorical and dimensional phenotypic characterization; environmental measurements with accuracy, validity, and biomarkers; statistical methods to address population stratification, multiple comparisons, and G×E of rare variants; animal models to test hypotheses; and new methods to broaden the capacity to search for G×E, including genome-wide and environment-wide association studies, precise estimation of heritability using dense genetic markers, and consideration of G×E both as the disease cause and a disease course modifier. Although examination of G×E appears to be a daunting task, tremendous recent progress in gene discovery has opened new horizons for advancing our understanding of the role of G×E in the pathogenesis of ASD and ultimately identifying the causes, treatments, and even preventive measures for ASD and other neurodevelopmental disorders.
- Published
- 2015
38. Autism Spectrum Disorder and School Bullying: Who Is the Victim? Who Is the Perpetrator?
- Author
-
Hwang, Soonjo, Kim, Young Shin, Koh, Yun-Joo, and Leventhal, Bennett L.
- Abstract
While a growing number of studies indicate associations between experiences of bullying and autism spectrum disorder (ASD), it is not clear what roles comorbid behavioral problems may play. We investigated the experiences of children with ASD as victims and/or perpetrators of bullying. Children with ASD epidemiologically ascertained participated in a cross-sectional study. Although children with ASD showed significantly increased risk for bullying involvement compared to community children, after controlling for comorbid psychopathology and other demographic factors, increased risks for being perpetrators or victim-perpetrators disappeared while risk for being bullied/teased continued to be significantly elevated. This finding will help guide medical, educational and community personnel to effectively identify children with ASD at risk for school bullying and develop interventions.
- Published
- 2018
- Full Text
- View/download PDF
39. Enhancing binomial and trinomial equity option pricing models
- Author
-
Kim, Young Shin, Stoyanov, Stoyan, Rachev, Svetlozar, and Fabozzi, Frank J.
- Published
- 2019
- Full Text
- View/download PDF
40. A Comparison of DSM-IV Pervasive Developmental Disorder and DSM-5 Autism Spectrum Disorder Prevalence in an Epidemiologic Sample
- Author
-
Kim, Young Shin, Fombonne, Eric, Koh, Yun-Joo, Kim, Soo-Jeong, Cheon, Keun-Ah, and Leventhal, Bennett L
- Subjects
Mental Health ,Behavioral and Social Science ,Brain Disorders ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,Clinical Research ,Autism ,Mental health ,Quality Education ,Child ,Child Development Disorders ,Pervasive ,Cross-Sectional Studies ,Diagnosis ,Differential ,Diagnostic and Statistical Manual of Mental Disorders ,Female ,Humans ,Male ,Republic of Korea ,Surveys and Questionnaires ,ASD ,DSM-5 ,DSM-IV ,SCD ,prevalence ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Developmental & Child Psychology - Abstract
ObjectiveChanges in autism diagnostic criteria found in DSM-5 may affect autism spectrum disorder (ASD) prevalence, research findings, diagnostic processes, and eligibility for clinical and other services. Using our published, total-population Korean prevalence data, we compute DSM-5 ASD and social communication disorder (SCD) prevalence and compare them with DSM-IV pervasive developmental disorder (PDD) prevalence estimates. We also describe individuals previously diagnosed with DSM-IV PDD when diagnoses change with DSM-5 criteria.MethodThe target population was all children from 7 to 12 years of age in a South Korean community (N = 55,266), those in regular and special education schools, and a disability registry. We used the Autism Spectrum Screening Questionnaire for systematic, multi-informant screening. Parents of screen-positive children were offered comprehensive assessments using standardized diagnostic procedures, including the Autism Diagnostic Interview-Revised and Autism Diagnostic Observation Schedule. Best-estimate clinical diagnoses were made using DSM-IV PDD and DSM-5 ASD and SCD criteria.ResultsDSM-5 ASD estimated prevalence was 2.20% (95% confidence interval = 1.77-3.64). Combined DSM-5 ASD and SCD prevalence was virtually the same as DSM-IV PDD prevalence (2.64%). Most children with autistic disorder (99%), Asperger disorder (92%), and PDD-NOS (63%) met DSM-5 ASD criteria, whereas 1%, 8%, and 32%, respectively, met SCD criteria. All remaining children (2%) had other psychopathology, principally attention-deficit/hyperactivity disorder and anxiety disorder.ConclusionOur findings suggest that most individuals with a prior DSM-IV PDD meet DSM-5 diagnostic criteria for ASD and SCD. PDD, ASD or SCD; extant diagnostic criteria identify a large, clinically meaningful group of individuals and families who require evidence-based services.
- Published
- 2014
41. Cyberbullying, problematic internet use, and psychopathologic symptoms among Korean youth.
- Author
-
Kim, Young Shin, Jung, Y-E, Leventhal, B, Kim, YS, Park, TW, Lee, S-H, Lee, M, Park, SH, Yang, J-C, Chung, Y-C, and Chung, S-K
- Abstract
To evaluate the associations between cyberbullying behaviors and problematic internet use, and to compare psychopathologic symptoms in victims, perpetrators, and victims-perpetrators of cyberbullying to those in youths who were not involved in cyberbullyin
- Published
- 2014
42. Recent challenges to the psychiatric diagnostic nosology: a focus on the genetics and genomics of neurodevelopmental disorders
- Author
-
Kim, Young Shin and State, Matthew W
- Subjects
Epidemiology ,Public Health ,Health Sciences ,Statistics ,Mathematical Sciences ,Mental Health ,Genetic Testing ,Intellectual and Developmental Disabilities (IDD) ,Brain Disorders ,Human Genome ,Autism ,Neurosciences ,Schizophrenia ,Genetics ,2.1 Biological and endogenous factors ,Aetiology ,Child ,Developmental Disabilities ,Diagnostic and Statistical Manual of Mental Disorders ,Genetic Markers ,Genomics ,Humans ,Intellectual Disability ,Phenotype ,Point Mutation ,nosology ,genetics ,genomics and etiology ,neurodevelopmental disorders ,Public Health and Health Services ,Public health - Abstract
Recent advances in the genetics of neurodevelopmental disorder (NDD) have demonstrated that rare mutations play a role not only in Mendelian syndromes, but in complex, common forms of NDDs as well. Strikingly, both common polymorphisms and rare variations in a single gene or genetic locus have been found to carry risk for conditions previously considered to be clinically and aetiologically distinct. Recent developments in the methods and tools available for studying complex NDDs have led to systematic and reliable genome-wide variant discovery. Both common as well as rare, and structural as well as sequence, genetic variations have been identified as contributing to NDDs. There are multiple examples in which the identical variant had been found to contribute to a wide range of formerly distinct diagnoses, including autism, schizophrenia, epilepsy, intellectual disability and language disorders. These include variations in chromosomal structure at 16p11.2, rare de novo point mutations at the gene SCN2A, and common single nucleotide polymorphisms (SNPs) mapping near loci encoding the genes ITIH3, AS3MT, CACNA1C and CACNB2. These selected examples point to the challenges to current diagnostic approaches. Widely used categorical schema have been adequate to provide an entré into molecular mechanisms of NDDs, but there is a need to develop an alternative, more biologically-relevant nosology. Thus recent advances in gene discovery in the area of NDDs are leading to a re-conceptualization of diagnostic boundaries. Findings suggest that epidemiological samples may provide important new insights into the genetics and diagnosis of NDDs and that other areas of medicine may provide useful models for developing a new diagnostic nosology, one that simultaneously integrates categorical diagnoses, biomarkers and dimensional variables.
- Published
- 2014
43. A systematic review of screening tools in non-young children and adults for autism spectrum disorder
- Author
-
Hirota, Tomoya, So, Ryuhei, Kim, Young Shin, Leventhal, Bennett, and Epstein, Richard A.
- Published
- 2018
- Full Text
- View/download PDF
44. Analysis of mechanical and flame‐retardant properties of flexible polyurethane foams.
- Author
-
Kim, Young Shin and Jeon, Euy Sik
- Subjects
FOAM ,FIREPROOFING ,URETHANE foam ,MELAMINE ,FIREPROOFING agents ,FIRE prevention ,PHOSPHATE esters ,INFRARED spectroscopy - Abstract
In this study, the mechanical and flame‐retardant properties of flexible polyurethane foams (FPUF) were analyzed as a function of the type of flame retardant. FPUF containing equal amounts of two halogenated flame retardants (tris 2‐cloropropyl phosphate [TCPP] and phosphinyl alkyl phosphate ester) and three halogen‐free flame retardants (melamine, melamine cyanurate, and expandable graphite) were considered. The foaming properties of these samples were analyzed by studying the rise time and settling rate using cup foaming. Square foaming was used to analyze the mechanical properties, including density, elongation, tensile strength, and tear strength. In addition, Fourier‐transform infrared spectroscopy was performed, and flame retardancy was evaluated using a horizontal flame test and the limited oxygen index. A cone calorimeter test was also performed to evaluate the combustion characteristics. In FPUF containing the same ratio of flame retardant (15% of the total polyol), the properties of urethane foam blended with expandable graphite were improved; the tensile strength of this blend is 20% higher than that of samples containing melamine, and its peak heat release showed a 70% reduction compared to that of samples containing TCPP. These findings provide valuable reference information for developing flame retardants for fire safety FPUF in the near future. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
45. Using a hydrogen gas torch to seal edges of vacuum glazing panels and analysis of the related characteristic strength according to the sealed edge shapes
- Author
-
Kim, Young Shin and Jeon, Euy Sik
- Published
- 2018
- Full Text
- View/download PDF
46. Sex difference in risk period for completed suicide following prior attempts: Korea National Suicide Survey (KNSS)
- Author
-
Kim, Bora, Lee, Joongyup, Kim, Eunyoung, Kim, Se Hyun, Ha, Kyooseob, Kim, Young Shin, Leventhal, Bennett L., and Ahn, Yong Min
- Published
- 2018
- Full Text
- View/download PDF
47. Tempered stable process, first passage time, and path-dependent option pricing
- Author
-
Kim, Young Shin
- Published
- 2019
- Full Text
- View/download PDF
48. Social stratification, classroom climate, and the behavioral adaptation of kindergarten children.
- Author
-
Boyce, W Thomas, Obradovic, Jelena, Bush, Nicole R, Stamperdahl, Juliet, Kim, Young Shin, and Adler, Nancy
- Subjects
Humans ,Prospective Studies ,Adaptation ,Psychological ,Child Behavior ,Social Behavior ,Social Dominance ,Child Development ,Mental Health ,Models ,Psychological ,Social Class ,Social Environment ,Students ,Child ,Child ,Preschool ,California ,Female ,Male ,Behavioral and Social Science ,Pediatric Research Initiative ,Pediatric ,Basic Behavioral and Social Science ,Reduced Inequalities ,child development ,social dominance ,stress ,mental health - Abstract
Socioeconomic status (SES) is the single most potent determinant of health within human populations, from infancy through old age. Although the social stratification of health is nearly universal, there is persistent uncertainty regarding the dimensions of SES that effect such inequalities and thus little clarity about the principles of intervention by which inequalities might be abated. Guided by animal models of hierarchical organization and the health correlates of subordination, this prospective study examined the partitioning of children's adaptive behavioral development by their positions within kindergarten classroom hierarchies. A sample of 338 5-y-old children was recruited from 29 Berkeley, California public school classrooms. A naturalistic observational measure of social position, parent-reported family SES, and child-reported classroom climate were used in estimating multilevel, random-effects models of children's adaptive behavior at the end of the kindergarten year. Children occupying subordinate positions had significantly more maladaptive behavioral outcomes than their dominant peers. Further, interaction terms revealed that low family SES and female sex magnified, and teachers' child-centered pedagogical practices diminished, the adverse influences of social subordination. Taken together, results suggest that, even within early childhood groups, social stratification is associated with a partitioning of adaptive behavioral outcomes and that the character of larger societal and school structures in which such groups are nested can moderate rank-behavior associations.
- Published
- 2012
49. Global prevalence of autism and other pervasive developmental disorders.
- Author
-
Kim, Young Shin, Elsabbagh, M, Divan, G, Koh, Y-J, Kim, YS, Kauchali, S, Marcín, C, Montiel-Nava, C, Patel, V, Paula, CS, and Wang, C
- Abstract
We provide a systematic review of epidemiological surveys of autistic disorder and pervasive developmental disorders (PDDs) worldwide. A secondary aim was to consider the possible impact of geographic, cultural/ethnic, and socioeconomic factors on prevalen
- Published
- 2012
50. Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population.
- Author
-
Kim, Se Joo, Kim, Young Shin, Kim, Chan-Hyung, and Lee, Hong Shick
- Subjects
Humans ,Personality ,Temperament ,Polymorphism ,Genetic ,Adult ,Korea ,Female ,Male ,Dopamine Plasma Membrane Transport Proteins ,Receptors ,Dopamine D4 ,Polymorphism ,Genetic ,Receptors ,Dopamine D4 ,General & Internal Medicine ,Medical and Health Sciences - Abstract
Human personality traits have a considerable genetic component. Cloninger et al. were the first to postulate that certain personality traits, such as novelty seeking, are related to the dopamine neurotransmitter system. In this study, we investigated the associations between dopamine receptor D4 (DRD4) exon III and dopamine transporter (DAT1) polymorphisms and personality traits. The DRD4 and DAT1 gene polymorphisms were genotyped in 214 healthy Korean subjects, whose personality traits were assessed with the Temperament and Character Inventory (TCI). There were no significant differences between scores of TCI temperament dimensions (novelty seeking, harm avoidance, reward dependence, and persistence) and DRD4 gene polymorphism. The DAT1 gene polymorphisms also showed no significant association with any of the temperament subscales of the TCI. These data suggest that DRD4 and DAT1 gene polymorphism may not associated with personality traits in a Korean population.
- Published
- 2006
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.