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Optimizing the hydraulic efficiency of submersible drainage pumps (SDPs) is crucial for energy conservation and performance enhancement, especially in emergency applications. Therefore, this study aims to develop an energy-efficient SDP by designing an optimized impeller model using a numerical scheme and introducing a flow balance block (FBB) as an alternative to modifying the pump casing, thereby reducing internal space and improving performance. Experimental validation of the optimized impeller and FBB was conducted by comparing their performance with the original pump model. The results demonstrated that the optimized impeller increased efficiency by 3.35% at a flow rate of 0.195 m3/min, with an overall average efficiency improvement of 2.33%. Additionally, when the optimized impeller and FBB were combined, the pump's efficiency was further enhanced by 5%, and the flow rate increased by approximately 10%. The study also proposed that the tap bolt method is more effective for installing the FBB than the silicone attaching method. This research provides a comprehensive experimental approach to improving SDP efficiency and offers valuable insights for future pump optimization. [ABSTRACT FROM AUTHOR]

Several studies have investigated predictive factors such as morphological, physiological, and fluid dynamics perspectives for obstructive sleep apnea (OSA) using computed tomography imaging, computer simulations, and experiments. Computational fluid dynamics is used in this study to analyze airflow in the upper airway across different body mass index (BMI) groups to identify suitable factors for predicting OSA. A comparative analysis is conducted on three groups: normal BMI (22.8 ± 1.0), overweight BMI (31.8 ± 1.5), and OSA (28.6 ± 3.3), with nine participants in each group. Geometric parameters were analyzed in addition to fluid dynamics factors. A comparison of the geometric variables revealed that the OSA group had the shortest total airway length (1.5 × 10−1 m) and the smallest volume (5.4 × 10−5 m3). However, t-test results showed low statistical significance for these differences. For fluid dynamics variables, the OSA group experienced the highest pressure drop (−46.8 Pa) and the highest adjusted pressure coefficient (Cp = 0.88) compared to the other two groups. From the analysis of breathing diagrams, the OSA group exhibited the largest area under the breathing power curve (32.6 × 10−3 N m/s) followed by the normal weight (24.9 × 10−3 N m/s) and overweight (21.0 × 10−3 N m/s) groups in descending order. Analysis of fluid dynamics factors indicated that the OSA group exhibited significantly higher pressure drop and pressure coefficient values compared to other groups although the differences between the groups were less significant. Finally, one key finding from this research highlights a new computational approach that relies on the breathing diagram. This new approach could provide more accurate insights into predicting and managing OSA due to their distinctive shapes. [ABSTRACT FROM AUTHOR]

The effect of side holes morphology changes in double J stent (DJS) on encrustation was analyzed using computational fluid dynamics (CFD). We analyzed DJS side holes with inner diameter of 1 mm and outer diameters of 1 (type A), 1.2 (type B) and 1.4 (type C) mm, respectively. Concentric stenosis with three intraureteral degree (0%, 12%, and 88%) was analyzed. The flow rate, shear stress and wall shear stress (WSS) distribution were investigated. Urine flow through SH1 before the ureteropelvic junction (UPJ) differed based on the ureteral stenosis degree. The sum of flow rates through the SHs increased with diameter. In the stented ureter with 12% stenosis, the flow rate through SH1 approximately doubled than that without ureteral stenosis, and the flow rate through SH1 was maximal for the type 'C' stent in both 12% and 88% ureteral stenosis. The mean shear stress in the SHs increased with the degree of stenosis. The WSS around the SHs was higher for type 'C' than types A and B. From the flow rates and shear stresses in and around the SHs, the larger SH diameter of the DJS from the UPJ to mid-ureter is expected to induce encrustation reduction, especially in patients with urinary lithiasis. [ABSTRACT FROM AUTHOR]

Submersible drainage pumps are used around the world both residentially and industrially for draining water and sewage. However, these pumps are prone to wear and clogging when the flows inward contain particles and air bubbles, and the combined effects of cavitation and erosion directly affect the performance of such pumps and degrade their efficiency. Therefore, it is essential to design a submersible pump that mitigates the adverse effects of cavitation and erosion. Reported here is an energy-efficient submersible drainage pump for use in emergency response. The combined cavitation–erosion effects are established in order to reduce their adverse impact on the pump, and how erosion wear affects the cavitation characteristics of the water in the pump is investigated. An experiment was conducted to verify the numerical results pump, and then, the influences of particle concentration and size on two-stage existing and altered model submersible pumps were analyzed using computational fluid dynamics. The results show that the performance of the altered model pump increased by 4.34%, with the cavitation–erosion effects reduced significantly. In addition, higher particle concentration induced higher erosion rates at both the leading and trailing edges of the impeller blades. Furthermore, the altered model significantly reduced the cavitation–erosion impact on the pump impeller blades compared to the existing model. [ABSTRACT FROM AUTHOR]

This study introduces a novel integration of dynamic mode decomposition (DMD) with physical regulations for natural gas pipeline flow. It aims to address the limitations of purely data-driven models and the importance of incorporating the physics of complex dynamic systems. By considering the mass conservation law, the proposed model ensures that the predictions generated via DMD with control adhere to the physical laws, resulting in a multi-objective optimization problem. To verify its performance, the proposed model was evaluated using real-world data of natural gas pipelines. The results demonstrate its superior accuracy and ability to avoid physically implausible predictions, particularly under data-limited conditions. Despite an increase in the overall computational cost by approximately 15%, the model achieved up to 50% error reduction with scarce training data, highlighting its robustness and effectiveness. This study represents a significant advancement in data-driven modeling techniques by fulfilling the critical need for accurate and reliable predictions that respect physical constraints, thus enhancing the interpretability and validity of the results. [ABSTRACT FROM AUTHOR]

This study investigated which sizes of double-J stents are more effective in achieving an acceptable urine flow through stenotic and stented ureters. Sixty four computational fluid dynamics models of the combinations of two different gauge ureters (4.57 mm and 5.39 mm in diameter) with four different levels of ureteral and four different sizes of double-J stents were developed for the numerical analysis of urine flow in the ureter. Luminal, extraluminal, and total flow rates along the ureter were measured, and the flow patterns around the ports and side holes were investigated. For the 4.57-mm ureter, the total flow rate for each gauge of stent was 23–63 mL/h (5 Fr), 20–47 mL/h (6 Fr), 17–35 mL/h (7 Fr), and 16–26 mL/h (8 Fr) and for the 5.39-mm ureter, the total flow rate for each gauge of stent was 43–147 mL/h (5 Fr), 36–116 mL/h (6 Fr), 29–92 mL/h (7 Fr), and 26–71 mL/h (8 Fr). With a 74% stenosis, all stents allowed a low flow rate, and the differences in flow rates between the stents were small. At the other levels of stenosis, 5 Fr stents allowed greater flow rates than the 8 Fr stents. The luminal flow rate increased just before the area of stenosis and decreased after the stenosis because of the increase and decrease in the luminal flow through the side holes before and after the stenosis. Therefore, a larger double-J stent is not favorable in achieving an acceptable urine flow through the stenotic and stented ureters. The results in this study could not be necessarily correlated with clinical situation because peristalsis, viscosity of the urine and real format of the ureter were not considered in our model. In vivo experiments are necessary for confirmation of our findings. Double J stents are commonly used in the ureteral stenosis or occlusion, especially due to ureter stones which obstruct the flow of urine. Clinicians choose the size of double J stent on the basis of their clinical experience. Here, we tried to know which sizes of double J stents are better for sufficient urine flow. According to various documents that try to determine the optimal shape of double J stents to increase the urine flow through the ureter, mostly bigger stent is recommended to occur maximum urine flow. However, in case of ureter with stenosis or occlusion, the right size of the double J stent may vary depending on the degree of stenosis in the ureter. To find appropriate stent size for the ureter with stenosis, computational fluid dynamics was conducted. This study shows that smaller diameter stents are more appropriate than larger diameter stents depending on the situation. [ABSTRACT FROM AUTHOR]

Bioinspired drug delivery: Topical formulations, transdermal patches, and microneedles can be used for drug delivery, avoiding the pain associated with hypodermic needle injections. Bae et al. developed flexible patches using microneedles to rapidly deliver liquid formulations through the skin. Inspired by rear-fanged snakes, the authors fabricated microneedles with open grooves that transdermally delivered dye-labeled proteinaceous solutions, liquid anesthetic, and a vaccine to guinea pigs and mice. Mice showed similar protection against influenza when immunized by microneedle patch or intramuscular injection. This flexible patch platform offers a versatile method of liquid drug delivery. A flexible microneedle patch that can transdermally deliver liquid-phase therapeutics would enable direct use of existing, approved drugs and vaccines, which are mostly in liquid form, without the need for additional drug solidification, efficacy verification, and subsequent approval. Specialized dissolving or coated microneedle patches that deliver reformulated, solidified therapeutics have made considerable advances; however, microneedles that can deliver liquid drugs and vaccines still remain elusive because of technical limitations. Here, we present a snake fang–inspired microneedle patch that can administer existing liquid formulations to patients in an ultrafast manner (<15 s). Rear-fanged snakes have an intriguing molar with a groove on the surface, which enables rapid and efficient infusion of venom or saliva into prey. Liquid delivery is based on surface tension and capillary action. The microneedle patch uses multiple open groove architectures that emulate the grooved fangs of rear-fanged snakes: Similar to snake fangs, the microneedles can rapidly and efficiently deliver diverse liquid-phase drugs and vaccines in seconds under capillary action with only gentle thumb pressure, without requiring a complex pumping system. Hydrodynamic simulations show that the snake fang–inspired open groove architectures enable rapid capillary force–driven delivery of liquid formulations with varied surface tensions and viscosities. We demonstrate that administration of ovalbumin and influenza virus with the snake fang–inspired microneedle patch induces robust antibody production and protective immune response in guinea pigs and mice. [ABSTRACT FROM AUTHOR]

Obstructive sleep apnea (OSA) is a syndrome characterized by the repetitive episodic collapse of the upper airway. The purpose of this study is to investigate the fluid dynamic parameters for the prediction of obstructive sleep apnea in the upper airway before and after setback surgery. Here, we analyzed the flow phenomena of inspiration and expiration in obstructive sleep apnea patients. The modeling of the upper airway was performed with facial 3 dimensional facial computed tomography images (3D facial CT). We used timedependent value for boundary conditions. The changes of pressure were studied with 3D facial CT taken both before and after the setback surgery. Further, it was found that the correlation between PSG data and non-dimensional pressure drop can be used to predict the severity of OSA. In all 6 patients except for patient 1, the average values of the non-dimensional pressure drops and PSG clinical data are inversely related. For each patient, the lower the pressure drop is, the higher the PSG values will be. [ABSTRACT FROM AUTHOR]

Ureteral stenosis presents with a narrowing in the ureter, due to an intrinsic or extrinsic ureteral disease, such as ureter cancer or retroperitoneal fibrosis. The placement of a double J stent in the upper urinary system is one of the most common treatments of ureteral stenosis, along with the insertion of a percutaneous nephrostomy tube into the renal pelvis. The effect that the side holes in a double J stent have on urine flow has been evaluated in a few studies using straight ureter models. In this study, urine flow through a double J stent's side holes was analyzed in curved ureter models, which were based on human anatomy. In ureteral stenosis, especially in severe ureteral stenosis, a stent with side holes had a positive effect on the luminal and total flow rates, compared with the rates for a stent without side holes. The more side holes a stent has, the greater the luminal and total flow rates. However, the angular positions of the side holes did not affect flow rate. In conclusion, the side holes in a double J stent had a positive effect on ureteral stenosis, and the effect became greater as the ureteral stenosis became more severe. [ABSTRACT FROM AUTHOR]

Purpose: To present a triangular-shaped abnormal secondary ossification center of the distal phalanx causing angular deformity of the thumb and the surgical outcome of corrective closing-wedge osteotomy for this deformity. Methods: We treated 6 patients with abnormal triangular epiphysis in the distal phalanx of the thumb, including 3 bilateral cases. The average age was 43 months and there were 2 boys and 4 girls. Of the 9 thumbs intraepiphyseal closing-wedge osteotomy was performed in 5 and proximal phalangeal closing-wedge osteotomy was performed in 4. We measured the deformities in degrees of angulation and the range of motion of the interphalangeal (IP) joint. The average duration of the follow-up period was 27 months after the surgery. Results: Preoperative angular deformity of ulnar deviation averaged 30°, which was reduced to an average of 12° after osteotomy at the last follow-up assessment. All osteotomies healed and there was no evidence of physeal or articular damage. Interphalangeal joint range of motion did not decrease after surgery in all cases. Patients and parents were satisfied with the results of the surgery, although mild deformity persisted in the interphalangeal joint when in the flexed position after proximal phalangeal osteotomy. Conclusions: Abnormal triangular epiphysis causing angled thumb is different from delta bone and can be treated with either intraepiphyseal or proximal phalangeal closing-wedge osteotomy. The intraepiphyseal procedure, however, could achieve better deformity correction regardless of the interphalangeal joint position. Type of study/level of evidence: Therapeutic, Level IV. [Copyright &y& Elsevier]

Discharge water from fish farms is a clean, renewable, and abundant energy source that has been used to obtain renewable energy via small hydropower plants. Small hydropower plants may be installed at offshore fish farms where suitable water is obtained throughout the year. It is necessary to meet the challenges of developing small hydropower systems, including sustainability and turbine efficiency. The main objective of this study was to investigate the possibility of constructing a small hydropower plant and develop 100 kW class propeller-type turbines in a fish farm with a permanent magnet synchronous generator (PMSG). The turbine was optimized using a computer simulation, and an experiment was conducted to obtain performance data. Simulation results were then validated with experimental results. Results revealed that streamlining the designed shape of the guide vane reduced the flow separation and improved the efficiency of the turbine. Optimizing the shape of the runner vane decreased the flow rate, reducing the water power and increasing the efficiency by about 5.57%. Also, results revealed that tubular or cross-flow turbines could be suitable for use in fish farm power plants, and the generator used should be waterproofed to avoid exposure to seawater. [ABSTRACT FROM AUTHOR]

This study aimed to analyze pharyngeal airflow characteristics and their relationship with the skeletal movement of the maxilla and mandible after bimaxillary orthognathic surgery in patients with skeletal class III (mandibular prognathism) malocclusion. Cone-beam computed tomography (CBCT) was conducted before surgery (T0), immediately after surgery (T1), and at least six months after surgery (T2). Digital imaging and communications in medicine files were transferred to InVivo (Anatomage) software to measure the skeletal changes after surgery. The changes in the maxillary and mandibular position, tongue position, and hyoid bone position were analyzed. Patient-specific models were reconstructed using 3D-Doctor software. The models after converting to the stereolithography (STL) file for Ansys integrated computer engineering and manufacturing code for computational fluid dynamics (ICEM CFD), commercial software were used for calculating the geometry, pressure drop and adjusted pressure coefficient value. The total volume of the upper airway including nasal cavity was reduced by 23% immediately after surgery and recovered to 92.2% of the initial volume six months after surgery. The airflow computation analysis showed a decrease in the pressure drop values immediately after surgery and six months after surgery. The adjusted pressure coefficients were slightly different but the change was statistically insignificant. The airflow characteristics computed using the computational fluid dynamics were correlated to the surgical changes. The surgical changes can affect the aerodynamics of the pharyngeal airway. In clinical practice, this knowledge is useful for developing a suitable orthognathic surgery treatment plan. [ABSTRACT FROM AUTHOR]

A double J stent (DJS) is used to alleviate the congestion of urine in the upper urinary tract when there is ureteral stenosis, which causes the interruption of normal urine flow and results in renal failure. The purpose of placing DJSs is to ensure sufficient urine flow in the ureter, but the DJS acts as a foreign body in the urinary system and sometimes acts as an obstacle in achieving sufficient urine flow. Here, to evaluate the performance of various sizes of DJSs, 5Fr (1.666 mm) to 8Fr (2.666 mm), in the ureter, silicon ureter models without stenosis, and a circulation setup were constructed. The total flow rates (TFRs) in the stented ureters were evaluated with an in vitro experiment. The TFRs in the 5Fr DJS were larger than those in the other sizes of DJS. As the size of DJS increased, the TFR decreased. Computational fluid dynamics was also applied to validate the experimental results. It was shown that the experimental results agreed well with the numerical results. [ABSTRACT FROM AUTHOR]

Effective hydraulic turbine design prevents sediment and cavitation erosion from impacting the performance and reliability of the machine. Using computational fluid dynamics (CFD) techniques, this study investigated the performance characteristics of sediment and cavitation erosion on a hydraulic Francis turbine by ANSYS-CFX software. For the erosion rate calculation, the particle trajectory Tabakoff–Grant erosion model was used. To predict the cavitation characteristics, the study's source term for interphase mass transfer was the Rayleigh–Plesset cavitation model. The experimental data acquired by this study were used to validate the existing evaluations of the Francis turbine. Hydraulic results revealed that the maximum difference was only 0.958% compared with the CFD data, and 0.547% compared with the experiment (Korea Institute of Machinery and Materials (KIMM)). The turbine blade region was affected by the erosion rate at the trailing edge because of their high velocity. Furthermore, in the cavitation–erosion simulation, it was observed that abrasion propagation began from the pressure side of the leading edge and continued along to the trailing edge of the runner. Additionally, as sediment flow rates grew within the area of the attached cavitation, they increased from the trailing edge at the suction side, and efficiency was reduced. Cavitation–sand erosion results then revealed a higher erosion rate than of those of the sand erosion condition. [ABSTRACT FROM AUTHOR]

The Kaplan turbine is an axial propeller-type turbine that can simultaneously control guide vanes and runner blades, thus allowing its application in a wide range of operations. Here, turbine tip clearance plays a crucial role in turbine design and operation as high tip clearance flow can lead to a change in the flow pattern, resulting in a loss of efficiency and finally the breakdown of hydro turbines. This research investigates tip clearance flow characteristics and undertakes a transient fast Fourier transform (FFT) analysis of a Kaplan turbine. In this study, the computational fluid dynamics method was used to investigate the Kaplan turbine performance with tip clearance gaps at different operating conditions. Numerical performance was verified with experimental results. In particular, a parametric study was carried out including the different geometrical parameters such as tip clearance between stationary and rotating chambers. In addition, an FFT analysis was performed by monitoring dynamic pressure fluctuation on the rotor. Here, increases in tip clearance were shown to occur with decreases in efficiency owing to unsteady flow. With this study's focus on analyzing the flow of the tip clearance and its effect on turbine performance as well as hydraulic efficiency, it aims to improve the understanding on the flow field in a Kaplan turbine. [ABSTRACT FROM AUTHOR]

The ureter provides a way for urine to flow from the kidney to the bladder. Peristalsis in the ureter partially forces the urine flow, along with hydrostatic pressure. Ureteral diseases and a double J stent, which is commonly inserted in a ureteral stenosis or occlusion, disturb normal peristalsis. Ineffective or no peristalsis could make the contour of the ureter a tube, a funnel, or a combination of the two. In this study, we investigated urine flow in the abnormal situation. We made three different, curved tubular, funnel-shaped, and undulated ureter models that were based on human anatomy. A numerical analysis of the urine flow rate and pattern in the ureter was performed for a combination of the three different ureters, with and without a ureteral stenosis and with four different types of double J stents. The three ureters showed a difference in urine flow rate and pattern. Luminal flow rate was affected by ureter shape. The side holes of a double J stent played a different role in detour, which depended on ureter geometry. [ABSTRACT FROM AUTHOR]

Atherosclerosis is a cardiovascular disease mainly caused by plaque deposition in blood vessels. Plaque comprises components such as thrombosis, fibrin, collagen, and lipid core. It plays an essential role in inducing rupture in a blood vessel. Generally, Plaque could be described as three kinds of elastic models: cellular Plaque, hypocellular Plaque, and calcified Plaque. The present study aimed to investigate the behavior of atherosclerotic plaque rupture according to different lipid cores using Fluid-Structure Interaction (FSI). The blood vessel was also varied with different thicknesses (0.05, 0.25, and 0.5 mm). In this study, FSI simulation with a cellular plaque model with various thicknesses was investigated to obtain information on plaque rupture. Results revealed that the blood vessel with Plaque having a lipid core represents higher stresses than those without a lipid core. Blood vessels' thin thickness, like a thin cap, results in more considerable than Von Mises stress. The result also suggests that even at low fracture stress, the risk of rupture due to platelet decomposition at the gap was more significant for cellular plaques., (© 2024 IOP Publishing Ltd.)

Purpose: To evaluate the formation of encrustation on double J stents (DJSs) using artificial urine., Materials and Methods: In this study, a static urinary system containing artificial urine was created, and a total of 45 DJSs were used to evaluate the formation of encrustation. Three groups of 15 DJSs were tested for 4, 8, or 14 weeks. The formation of encrustation on the DJSs over the weeks was analyzed using methods including X-ray powder diffraction (XRD), inductively coupled plasma spectrophotometer (ICP), and scanning electron microscope (SEM). Statistical analysis and the uncertainty test were used for data analysis using R language., Results: The ICP analyzed the weight of the calcium and magnesium, which are the major components of urinary stones and encrustation, and showed that it was the heaviest at 14 weeks. Measurement of the area of encrustation on the outer surface of the DJSs revealed that the encrustation area at the bottom of the stent was greater than that at the top of the stent, regardless of the experimental period (proximal part: ≤ 41,099 µm 2 , distal part: ≤ 183,259 µm 2 ). Encrustation occurred around the side holes of DJSs and became bigger over time to fill up the side holes., Conclusion: Encrustation spots included the bottom zone of the DJS and around the side holes. These results indicate that the performance of DJSs would be improved by modifying the shape of DJSs located near the bladder and side holes.

Objective: To analyze the computational fluid dynamics (CFD) of femoral artery pseudoaneurysm (FAP), identify a suitable location and timing for percutaneous thrombin injection (PTI) based on this analysis, and report our clinical experience with the procedure., Materials and Methods: CFD can be used to analyze the hemodynamics of the human body. An analysis using CFD recommended that the suitable location of the needle tip for PTI is at the center of the aneurysm sac and the optimal timing for starting PTI is during the early inflow phase of blood into the sac. Since 2011, seven patients (three male and four female; median age, 60 years [range, 43-75 years]) with FAP were treated with PTI based on the devised suitable location and time. Prior to the procedure, color Doppler ultrasonography was performed to determine the location and timing of the thrombin injection., Results: The technical success rate of the PTI was 100%. The amount of thrombin used for the procedure ranged from 200 IU to 1000 IU (median, 500 IU). None of the patients experienced any symptoms or signs of embolic complications during the procedure. Follow-up CT images did not reveal any embolism in the lower extremities and showed complete thrombosis of the pseudoaneurysm., Conclusion: Based on our study of CFD, PTI administered centrally in the FAP during early inflow, as seen on color Doppler, can be an effective technique., Competing Interests: The authors have no potential conflicts of interest to disclose., (Copyright © 2021 The Korean Society of Radiology.)

Objective: The objective of this study was to investigate the effects of miniscrew-assisted rapid palatal expansion (MARPE) on changes in airflow in the upper airway (UA) of an adult patient with obstructive sleep apnea syndrome (OSAS) using computational fluid-structure interaction analysis., Methods: Three-dimensional UA models fabricated from cone beam computed tomography images obtained before (T0) and after (T1) MARPE in an adult patient with OSAS were used for computational fluid dynamics with fluid-structure interaction analysis. Seven and nine cross-sectional planes (interplane distance of 10 mm) in the nasal cavity (NC) and pharynx, respectively, were set along UA. Changes in the cross-sectional area and changes in airflow velocity and pressure, node displacement, and total resistance at maximum inspiration (MI), rest, and maximum expiration (ME) were investigated at each plane after MARPE., Results: The cross-sectional areas at most planes in NC and the upper half of the pharynx were significantly increased at T1. Moreover, airflow velocity decreased in the anterior NC at MI and ME and in the nasopharynx and oropharynx at MI. The decrease in velocity was greater in NC than in the pharynx. The airflow pressure in the anterior NC and entire pharynx exhibited a decrease at T1. The amount of node displacement in NC and the pharynx was insignificant at both T0 and T1. Absolute values for the total resistance at MI, rest, and ME were lower at T1 than at T0., Conclusions: MARPE improves airflow and decreases resistance in UA; therefore, it may be an effective treatment modality for adult patients with moderate OSAS., Competing Interests: The authors report no commercial, proprietary, or financial interest in the products or companies described in this article.

Objective: The aim of the study was to compare the effect of conventional maxillomandibular advancement (MMA) and modified MMA with anterior segmental setback osteotomy (MMA-ASSO) on the airway changes in patients with obstructive sleep apnea syndrome (OSAS) using three-dimensional computational fluid dynamics (3D-CFD) analysis., Methods: Two adult male patients with Class I malocclusion, lip protrusion, acute nasolabial angle, and OSAS were treated with conventional MMA (Case 1) and modified MMA-ASSO (Case 2). Individualized 3D airway models were fabricated using computed tomography data obtained 1 month before (T0) and at least 6 months after surgery (T1). A total of 7 cross-sectional areas of the airway were established, starting just above the hard palate (plane 1) with interval of 1 mm caudally. Airflow velocity and negative pressure were investigated using CFD analysis, and polysomnography studies were performed at T0 and T1., Results: There were improvement of apnea-hypoapnea index and the lowest O2 level (T0 versus T1; 43.2 versus 15.2, 79% versus 90% in Case 1; 61.0 versus 6, 89% versus 92% in Case 2). At plane 2 (retropalatal area) in Cases 1 and 2, there were increase in the smallest cross-sectional areas (57.9% versus 28.4%), decrease in the airflow velocity and increase in the negative pressure at the peak of expiration (49.5% versus 31.7%; 88.4% versus 54.3%), end after expiration (53.2% versus 32.2%; 83.2% versus 47.9%), and peak of inspiration (53.1% versus 29.2%; 75.3% versus 48.2%)., Conclusion: Modified MMA-ASSO method might be an effective treatment option for OSAS patients with improvement of airway problems and esthetic facial profile.

A double J stent has been used widely these days for patients with a ureteral stenosis or with renal stones and lithotripsy. The stent has multiple side holes in the shaft, which supply detours for urine flow. Even though medical companies produce various forms of double J stents that have different numbers and positions of side holes in the stent, the function of side holes in fluid dynamics has not been studied well. Here, the flow rate and pattern around the side holes of a double J stent were evaluated in curved models of a stented ureter based on the human anatomy and straight models for comparison. The total flow rate was higher in the stent with a greater number of side holes. The inflow and outflow to the stent through the side holes in the curved ureter was more active than in the straight ureter, which means the flow through side holes exists even in the ureter without ureteral stenosis or occlusion and even in the straight ureter. When the diameter of the ureter changed, the in-stent flow rate in the ureter did not change and the extraluminal flow rate was higher in the ureter with a greater diameter.

A ureteral stenosis or occlusion causes the disturbance of normal urine flow and results in renal failure. Ureteral stents are used to relieve the stagnation of urine in the upper urinary tract. Peristalsis in the ureter, which occurs to help urine flow, becomes to weaken when a stent is inserted and effective peristalsis disappears as time goes on, and a stented ureter seems to be tubular and curved in the human body. Double J stents, which are manufactured by many medical companies and are used widely these days, have different geometries of side holes in the stent shafts. In total, 12 models-six curved models of a stented ureter according to different numbers and positions of side holes and ureteral and stent stenoses and another six straight models for comparison with the curved ones-were made based on the data collected from 19 men. The flow rate and pattern in the stented ureter were evaluated using computational fluid dynamics (CFD). According to the results, curved models reflecting the human anatomy seem to be more desirable in the CFD simulation of urine flow and must be good for evaluating the effect of geometrical variations in stent design on urine flow.