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Your search keyword '"Khodzhimatov, Olimjon K."' showing total 8 results
Start Over Author "Khodzhimatov, Olimjon K." Publication Type Academic Journals
8 results on '"Khodzhimatov, Olimjon K."'

8. New icetexane and 20 norabietane diterpenes with trypanocidal activity from Dracocephalum komarovi.

Author

Uchiyama N, Kiuchi F, Ito M, Honda G, Takeda Y, Khodzhimatov OK, and Ashurmetov OA

Subjects
Animals, Diterpenes chemistry, Diterpenes pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Trypanocidal Agents chemistry, Trypanocidal Agents pharmacology, Diterpenes isolation & purification, Lamiaceae chemistry, Plants, Medicinal chemistry, Trypanocidal Agents isolation & purification, Trypanosoma cruzi drug effects
Abstract

Two new icetexane diterpenes, cyclocoulterone (1) and komaroviquinone (2), and a novel 20-norabietane diterpene, dracocephalone A (3), were isolated from Dracocephalum komarovi. Their structures were elucidated by extensive analyses of spectral data. Komaroviquinone (2) showed strong trypanocidal activity against epmastigotes of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 0.4 micro M.

Published
2003
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