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Background Objective Methods Results Conclusion Glucocerebrosidase 1 (GBA1) mutations are associated with reduced survival in Parkinson's disease but their effect on survival in dementia with Lewy bodies (DLB) is unclear.To assess the impact of GBA1 mutations on survival among Ashkenazi Jews with DLB, while controlling for APOE status.One hundred and forty participants from Tel Aviv Medical Center, Israel were genotyped for GBA1 mutations and APOE polymorphisms. Survival rates and follow‐up cognitive screening scores were analyzed.GBA1 mutation carriers had a two‐fold increased risk of death (HR = 1.999), while APOE status did not independently affect survival. In a subset of patients with available clinical data (N = 63), carriers of the APOE ε4 allele showed faster cognitive deterioration, while GBA1 mutation carriers also declined more rapidly albeit not significantly.Understanding the genetic effects on survival and progression is crucial for patient counseling and inclusion in clinical trials. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

The solution and verification of single-digit multiplication problems vary in speed and accuracy. The current study examines whether the number of different digits in a problem accounts for this variance. In Experiment 1, 41 participants solved all 2–9 multiplication problems. In Experiment 2, 43 participants verified these problems. In Experiment 3, 26 participants solved 10 problems that differed in shared-digit network (SDN) size and matched in problem size. In Experiment 4, 24 participants verified these matched sets. Results show faster and more accurate responses to problems that include fewer different digits relative to problems with more different digits, and faster and more accurate responses to problems whose SDN is small relative to problems whose SDN is large. We thus show that the number of different digits in a problem, including the operands and the solution, determines the speed and accuracy of its solution and verification. This parsimonious account also explains why responses to five and tie problems, which include fewer different digits relative to nonfive and nontie problems, are faster and more accurate than responses to other problems. [ABSTRACT FROM AUTHOR]

Background: Vocabulary scores increase until approximately age 65 years and then remain stable or decrease slightly, unlike scores on tests of other cognitive abilities that decline significantly with age. Aims: To review the findings on ageing‐related changes in vocabulary, and to discuss four methodological issues: research design; test type; measurement; and vocabulary ability as a proxy for general intelligence. Main Contribution: A discussion of cross‐sectional and longitudinal research designs shows that cohort membership accounts for some but not all ageing‐related changes in vocabulary, and that drop‐out and test–retest effects do not alter conclusions regarding these changes. Test type affects age trends in vocabulary, and if researchers use only one test, they should choose a multiple‐choice synonym test. While some authors suggest that vocabulary tests do not measure the same underlying ability in younger and older adults, more research of this suggestion is needed. A brief examination of the use of vocabulary ability as a proxy for general intelligence in healthy ageing and for premorbid abilities in dementia indicates that such practice is often questionable. Conclusions: Vocabulary knowledge increases through the mid‐60s regardless of measurement method. However, there is little information on how word knowledge serves other verbal skills in old age, how and when adults learn new words, or how much exposure is necessary for meanings to remain in storage for a lifetime. Research of these issues may require new methodologies, as well as novel theoretical accounts of ageing‐related effects on vocabulary. WHAT THIS PAPER ADDS: What is already known on this subject: Unlike many cognitive abilities that decline with ageing, vocabulary knowledge continues to increase until approximately age 65, and then remains stable or decreases slightly. These findings have been replicated in different research designs and across languages. What this paper adds to existing knowledge: The article presents a summary of findings on changes in vocabulary across adulthood, and a discussion of four key methodological issues: research design, test type, measurement, and the use of vocabulary ability as a proxy for general intelligence. What are the potential or actual clinical implications of this work?: To better understand changes in vocabulary knowledge across adulthood, clinicians must be aware of methodological considerations that affect the field. Such considerations have direct clinical implications regarding the choice of vocabulary tests and their use as a proxy for other abilities in both healthy older adults and in individuals with dementia. [ABSTRACT FROM AUTHOR]

This research examines anthropomorphism by testing the values that people attribute to electronic devices. We ask four main questions: Do people attribute human values to devices; Do devices differ in their value profiles; What underlies the attribution of values to devices; and Do individual and social differences affect these attributions. In Study 1, participants (N = 265) attributed Schwartz's 10 basic human values to devices, reported their personal value priorities, as well as the frequency and difficulty in using each device. In Study 2, participants (N = 231) attributed values to devices, and responses were analyzed by age. Results show that people attribute human values to electronic devices, and that each device has a unique value profile. Anthropomorphizing devices reflects social consensus as to the symbolic meaning of each device, rather than projection of personal values or frequency of device use. Members of social groups share device values and differ from members of other groups. [ABSTRACT FROM AUTHOR]

Objectives This study aimed to examine which verbal fluency task is most useful in assessing adolescents with reading disorders (RD). Method Eighty-three Hebrew-speaking adolescents (ages 12–15), 42 of them with RD, completed semantic and phonemic fluency tasks, and their scores were converted to standardized scores according to population norms. Results Scores on the semantic task were similar in the RD and the control group, unlike scores on the phonemic task, which were significantly lower in the RD group. The RD group demonstrated higher semantic than phonemic scores, unlike the control group whose standardized scores on both tasks were similar. Phonemic but not semantic fluency scores predicted spelling scores within the RD group. Conclusions Adolescents with RD have no difficulty on a semantic fluency task, but perform below expected age-matched levels on the phonemic fluency task. To document this task-difference, practitioners must administer both fluency tasks when assessing RD. [ABSTRACT FROM AUTHOR]

The current study compared the assessment of memory with a translated story recall test and its original published norms and an equivalent local test with local norms. Analyses used data from 232 individuals with memory complaints who underwent neuropsychological evaluation at an outpatient memory clinic. One group of participants completed a translated test (N = 126) and another group completed a local test (N = 106). Additionally, participants completed tasks of word list recall, picture naming, and verbal fluency, all having local norms. The results showed that raw scores on the delayed story recall test, and on all other cognitive tasks, did not differ across groups, and the cross-task correlations were significant and similar in size in both groups. Yet, there was an interaction between group and standardized tests scores, whereby the standardized scores on the translated story recall test were equivalent to population mean, whereas all other scores fell below the mean. Conversion of raw scores to the original norms indicated that the performance of individuals with memory complaints was intact, while conversion of scores on a local test to local norms revealed the expected memory impairment. The findings highlight the importance of using local tests and local norms in the assessment of memory. [ABSTRACT FROM AUTHOR]

Older adults consistently report young subjective age and provide high ratings of their subjective health. The current research examined which social comparisons older adults make when they assess their subjective age and health, as well as the effects of experimentally manipulated social comparisons on these assessments. In Study 1, 146 participants (aged 60 and over) reported to whom they compared themselves when assessing their subjective age or health. In Study 2, 100 participants (aged 60 and over) reported their subjective age and health after receiving feedback that compared them to younger adults or to their peers. Study 1 shows that participants compared themselves primarily to their peer group. Yet, individuals who selected a younger comparison group when assessing subjective age reported a younger subjective age, better self-rated health and more positive expectations regarding ageing relative to those who selected their peers as a comparison group. No equivalent differences emerged in any of the measures when participants were divided by their selection of comparison group after providing their self-rated health ratings. In Study 2, feedback that emphasised the performance of younger people led to reports of younger subjective age relative to feedback that emphasised peer performance, with no equivalent difference for self-rated health. These findings help explain why older adults feel younger and healthier than they actually are. We suggest that older adults use social comparisons as a strategy that protects them from the negative effects of ageing on self-perception. [ABSTRACT FROM AUTHOR]

This cross-sectional study examined whether views of aging (VoA) relate to subjective cognitive complaints in two separate cohorts of older adults. Ageist attitudes, attitudes to aging (psychological loss, physical change, and psychological growth), subjective age, and subjective successful aging were examined. A moderating effect of chronological age was also examined. Samples included 572 adults aged 50 or older (Sample 1; mean age = 67.63, SD = 11.39, 49.4% female) and 224 adults aged 65 or older (Sample 2; mean age = 81.50, SD = 6.61, 75.3% female). More negative VoA (higher ageist attitudes, lower psychological growth, lower physical change, older subjective age, and less successful aging) were associated with more subjective cognitive complaints after controlling for covariates. An increase in chronological age strengthened some of these associations. Findings suggest that improving dimensions of VoA may have a complementary positive effect on subjective cognitive complaints in older adults. [ABSTRACT FROM AUTHOR]

This study examines whether age associates with entrepreneurship tendencies across the lifespan, after taking into account aspects of personality that affect entrepreneurship. Participants (N = 963) aged 18–81, including 200 actual entrepreneurs, completed questionnaires about entrepreneurship tendency, personality traits, and attachment orientations. Results show that age is associated with a reduced tendency to engage in entrepreneurial activity. However, this decline is quite limited, it weakens with age, and is absent after age 50. In addition, the negative association of age with entrepreneurial tendency is smaller in participants with above-median entrepreneurship tendency scores relative to those with below-median scores, and it disappears in actual entrepreneurs. Furthermore, most of the traits that have been previously associated with entrepreneurial tendencies, especially Openness to Experience and Extraversion, remain unchanged with age, accounting for the stability of entrepreneurial tendency over time. The results have implications for policy makers who wish to encourage older adults to engage in entrepreneurial activity. [ABSTRACT FROM AUTHOR]

Previous research has assumed that all types of semantic knowledge are similarly affected by aging. We investigate whether knowledge of vocabulary and math concepts show comparable lifetime change. A sample of 252 participants aged 17–91 completed two multiple-choice tasks that examined knowledge of infrequent word meanings and knowledge of basic math concepts. Up to age 64, vocabulary scores improved, whereas math scores remained stable. After that age, vocabulary scores remained stable, while math scores declined. We suggest that the fact that the learning and use of infrequent vocabulary are incidental, incremental, and contextual contributes to maintenance of word knowledge into old age. In contrast, learning of basic math concepts occurs relatively early in life in an intentional manner, and both learning and use of these concepts involve constrained contexts. Thus, the nature of the acquisition and use of semantic knowledge across the lifespan affects its fate in old age. [ABSTRACT FROM AUTHOR]

Objectives This study examined the longitudinal relationships between subjective age (SA) and future functional status in later life, via depressive symptoms. Additionally, we assessed the role of subjective nearness to death (SNtD) as a potential moderator within these pathways. Methods Older adults (average age 81.14 years at T1) were interviewed once a year for 3 consecutive years (N = 224 at T1, N = 178 at T2, and N = 164 at T3). Participants reported their SA, SNtD, depressive symptoms, and functional status. Additionally, grip strength was employed as an objective measure of functional status. Results Data analysis revealed distinct pathways leading from T1 SA to T3 functional status through T2 depressive symptoms. Moreover, T1 SNtD was found to significantly moderate most of these indirect pathways, so that the mediation model of T1 SA–T2 depressive symptoms–T3 functional status was mostly significant among those who felt closer to death. Discussion The findings contribute to our understanding of the underlying mechanism through which SA predicts long-term functioning sequelae by underscoring the indirect effect of depressive symptoms. They further indicate the importance of gauging the effects of SNtD on these longitudinal relationships. Present results may further contribute to establishing an integrative model for predicting long-term functional outcomes based on older adults' earlier subjective views of aging. [ABSTRACT FROM AUTHOR]

Background: Glucocerebrosidase (GBA) gene mutations and APOE polymorphisms are common in dementia with Lewy bodies (DLB), however their clinical impact is only partially elucidated.Objective: To explore the clinical impact of mutations in the GBA gene and APOE polymorphisms separately and in combination, in a cohort of Ashkenazi Jewish (AJ) patients with DLB.Methods: One hundred consecutively recruited AJ patients with clinically diagnosed DLB underwent genotyping for GBA mutations and APOE polymorphisms, and performed cognitive and motor clinical assessments.Results: Thirty-two (32%) patients with DLB were carriers of GBA mutations and 33 (33%) carried an APOE ɛ4 allele. GBA mutation carriers had a younger age of onset (mean [SD] age, 67.2 years [8.9] versus 71.97 [5.91]; p = 0.03), poorer cognition as assessed by the Mini-Mental State Examination (21.41 [6.9] versus 23.97 [5.18]; p < 0.005), and more severe parkinsonism as assessed with the Unified Parkinson's Disease Rating Scale motor part III (34.41 [13.49] versus 28.38 [11.21]; p = 0.01) compared to non-carriers. There were statistically significant interactions between the two genetic factors, so that patients who carried both a mild GBA mutation and the APOE ɛ4 allele (n = 9) had more severe cognitive (p = 0.048) and motor dysfunction (p = 0.037).Conclusion: We found a high frequency of both GBA mutations and the APOE ɛ4 allele among AJ patients with DLB, both of which have distinct effects on the clinical disease phenotype, separately and in combination. [ABSTRACT FROM AUTHOR]

Objective The current study examines whether Israeli physicians are familiar with neuropsychological assessment (NPA) in general and with referral to NPA in particular. Method In total, 274 physicians in relevant fields participated in an online survey that targeted levels of familiarity with NPA, beliefs about assessment needs, and actual referral practices. Results Israeli physicians see many patients with neuropsychological difficulties, but assess fewer patients for these difficulties by themselves. Approximately 80% of participants reported that they had heard of NPA before, but only 25% knew how to refer patients to NPA. Familiarity was greater among neurologists and neurosurgeons than among family doctors. Conclusions Physicians had only general knowledge about NPA, with little practical understanding of how to refer patients to such a service. To increase referral rates and create consistent demand for effective neuropsychological services, neuropsychologists should engage in greater advocacy activity that will lead to clarification of referral procedures. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to examine whether the discrepancy between participant and informant estimation of memory decline can predict MCI prognosis.Methods: Analyses involved data from individuals with MCI enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire. Participants who underestimated (N = 112) and overestimated (N = 157) their memory decline were compared on memory tasks, brain volume, and cerebrospinal markers, at study entry and after 24 months.Results: Individuals who underestimated their memory decline performed more poorly on memory tests, had smaller hippocampus volume, and greater Alzheimer's disease pathology than did individuals who overestimated their cognitive decline. Longitudinal comparisons demonstrated that individuals who underestimated their decline deteriorated more significantly in memory and in brain measures.Conclusions: Underestimation of memory decline should raise clinicians' suspicion of the existence of AD pathology in individuals with MCI. [ABSTRACT FROM AUTHOR]

Previous research has documented conflicting findings regarding the effect of word frequency on spelling in older adults. The current study examines spelling in Hebrew, in which it is easier to define the type of likely misspellings in each word. Younger and older Hebrew speakers spelled 120 single words that differed in word and letter frequency. Results show that all participants made more phonological substitutions of target letters on low-frequency words and on words with low-frequency letters. Yet, younger adults had a lower percentage of correct responses than did older adults, especially on low-frequency words. Vocabulary knowledge eliminated this age effect. We suggest that aging leads to greater reliance on full lexical retrieval of spelling instead of on sublexical phoneme-to-grapheme processing, due to years of exposure to written language, increase in vocabulary, and consolidation of orthographic representations. [ABSTRACT FROM AUTHOR]

The current study aims to examine the effect of technology use on the assessment of subjective age across the adult lifespan, with the assumption that using technology might make older people feel older. One-hundred and fifty-one participants (ages 18–83) assessed their subjective age before and after using familiar and unfamiliar applications on a touchscreen tablet. Subjective age was assessed either by line marking or by numerical response. The oldest participants felt older after the manipulation relative to their pre-manipulation baseline, unlike the youngest participants in the sample. This effect was stronger for the unfamiliar application than for the familiar application. We suggest that using technology evokes stereotype threat. Although this threat does not impair performance, it still changes self perception. These findings could have far-reaching implications for the well-being of older adults in an ever more technological world. [ABSTRACT FROM AUTHOR]

Objectives: The aim of this study was to examine awareness of decline in memory and in language in individuals with Alzheimer's disease (AD), by comparing participant and informant ratings, as well as these ratings and actual test performance.Methods: We analyzed data from 149 individuals with AD enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI) who filled the Everyday Cognition questionnaire and performed memory and language tasks.Results: Participants provided significantly lower assessments of decline than did informants for both memory and language. There was a negative association between informant ratings and memory test scores but no association between participant ratings and memory test scores. Both participant and informant ratings correlated negatively with performance on the language tests. Informant, but not participant, ratings contributed to the prediction of one memory variable beyond demographic factors. Participant ratings contributed to the prediction of language scores beyond demographic factors more than did informant ratings.Conclusions: The findings reflect better awareness of decline in language than of decline in memory in individuals with AD. [ABSTRACT FROM AUTHOR]

Objectives The present study examines which factors older adults consider as important when rating their subjective nearness-to-death (SNtD), as well as the associations between corresponding variables as reported in a multidimensional questionnaire and responses on a SNtD question. In addition, we examine whether importance ratings fit or diverge from the actual associations between corresponding variables and SNtD. Method Two hundred and seventy-two participants (average age 80.75) reported their health and functioning, their SNtD, and the importance of each of 13 preselected factors in evaluating SNtD. Results Respondents considered physical functioning and psychological factors as the most important factors to their SNtD evaluation, and genetic factors (i.e. age, gender, parental longevity) as the least important. Ratings of importance were strongly and positively correlated with the strength of the associations between the corresponding variables and SNtD. Discussion Older adults appear to have implicit knowledge of the factors that affect their SNtD. Yet, this knowledge is sometimes biased and does not necessarily represent variables that have been identified as related to actual longevity. [ABSTRACT FROM AUTHOR]

Purpose: This research aimed to investigate whether demographic factors are similarly related to retrieval of object and proper names. Methods: The sample included 5,907 individuals above age 70 who participated in the Health and Retirement Study between 2004 and 2012. Participants were asked to name two objects as well as the US President and Vice President. Latent growth curve models examined the associations of age, education, and self-rated health with baseline levels and change trajectories in retrieval. Results: Age and education were more strongly related to retrieval of proper names than to retrieval of object names, both for baseline scores and for change trajectory. Similar effects of self-rated health emerged for both types of stimuli. Conclusions: The results show that examining object names and proper names together as indication of cognitive status in the HRS might overlook important differences between the two types of stimuli, in both baseline performance and longitudinal change. [ABSTRACT FROM AUTHOR]

Background: Language assessment in Alzheimer’s disease (AD) demonstrates deficits in single-word production, but rarely includes connected speech. Aims: If Alzheimer’s disease leads to deficits in lexical retrieval, we should find reduced word output in connected speech, limited lexical diversity, an increase in retrieval errors, and an association between scores on tests of single-word production and measures of word retrieval in context. The purpose of this review was to investigate these hypotheses across studies of connected speech in AD. Main Contribution: A search of Medline and PsychNET identified 51 articles (published in 1985–2016) that reported data from 1,114 individuals with AD and 1,280 cognitively healthy individuals. A meta-analysis showed a significant but small reduction in word output in AD. No consistent decrease in the proportion of unique words was documented, but there was indication that individuals with AD produce more frequent words than do controls. An analysis of errors documented a moderate effect size, showing that individuals with AD commit more retrieval errors of all types. A relatively strong association was found between picture-naming scores and measures of word retrieval in connected speech. Conclusions: The review shows that individuals with AD experience significant lexical retrieval difficulties in connected speech. [ABSTRACT FROM PUBLISHER]

Background:Studies of connected speech of individuals with Alzheimer’s disease (AD) report significant impairments relative to the language of cognitively intact participants. Considerably less research has focused on the association between dementia severity and language features. Aims:The current study examines how scores on a dementia screening test (the Mini-Mental Status Examination, MMSE) correlate with features of connected speech. Methods & Procedures:Thirty-five individuals with AD (range of MMSE scores = 3–25) and 35 cognitively intact participants provided picture descriptions. Ten language features were derived from their descriptions using an automated text analysis tool: total word number, percentage of content words, pronoun ratio, type-token ratio, mean word frequency, percentage of verbs, percentage of verbs in the most common morphological form in Hebrew, percentage of verbs in present tense, percentage of prepositions, and percentage of subordination markers. Information content was also analysed. Outcomes & Results:Group differences emerged in five language features as well as in information content, attesting for substantial lexical impairment in AD. Within the AD group, MMSE scores were correlated with type-token ratio, with mean word frequency, and with the number of information units. No equivalent correlations were found within the control group. Conclusions: Dementia severity associates with decreasing lexical diversity, increasing word frequency, and a reduction in relevant information content, but not with changes in grammatical features of language. A simple automated analysis of connected speech could be used clinically to define and track the decline in language abilities in AD. [ABSTRACT FROM PUBLISHER]

We conducted a comprehensive literature review of studies of word retrieval in connected speech in healthy aging and reviewed relevant aphasia research that could shed light on the aging literature. Four main hypotheses guided the review: (1) Significant retrieval difficulties would lead to reduced output in connected speech. (2) Significant retrieval difficulties would lead to a more limited lexical variety in connected speech. (3) Significant retrieval difficulties would lead to an increase in word substitution errors and in pronoun use as well as to greater dysfluency and hesitation in connected speech. (4) Retrieval difficulties on tests of single-word production would be associated with measures of word retrieval in connected speech. Studies on aging did not confirm these four hypotheses, unlike studies on aphasia that generally did. The review suggests that future research should investigate how context facilitates word production in old age. [ABSTRACT FROM PUBLISHER]

What can tests of single-word production tell us about word retrieval in connected speech? We examined this question in 20 people with Alzheimer’s disease (AD) and in 20 cognitively intact individuals. All participants completed tasks of picture naming and semantic fluency and provided connected speech through picture descriptions. Picture descriptions were analyzed for total word output, percentages of content words, percentages of nouns, and percentages of pronouns out of all words, type–token ratio of all words and type–token ratio of nouns alone, mean frequency of all words and mean frequency of nouns alone, and mean word length. Individuals with AD performed worse than did cognitively intact individuals on the picture naming and semantic fluency tasks. They also produced a lower proportion of content words overall, a lower proportion of nouns, and a higher proportion of pronouns, as well as more frequent and shorter words on picture descriptions. Group differences in total word output and type–token ratios did not reach significance. Correlations between scores on tasks of single-word retrieval and measures of retrieval in picture descriptions emerged in the AD group but not in the control group. Scores on a picture naming task were associated with difficulties in word retrieval in connected speech in AD, while scores on a task of semantic verbal fluency were less useful in predicting measures of retrieval in context in this population. [ABSTRACT FROM PUBLISHER]

We conducted a comprehensive literature review of studies of word retrieval in connected speech in healthy aging and reviewed relevant aphasia research that could shed light on the aging literature. Four main hypotheses guided the review: (1) Significant retrieval difficulties would lead to reduced output in connected speech. (2) Significant retrieval difficulties would lead to a more limited lexical variety in connected speech. (3) Significant retrieval difficulties would lead to an increase in word substitution errors and in pronoun use as well as to greater dysfluency and hesitation in connected speech. (4) Retrieval difficulties on tests of single-word production would be associated with measures of word retrieval in connected speech. Studies on aging did not confirm these four hypotheses, unlike studies on aphasia that generally did. The review suggests that future research should investigate how context facilitates word production in old age. [ABSTRACT FROM AUTHOR]

The aim of this study was to examine whether performance on phonemic and semantic fluency tasks follows similar lifespan trajectories. Data from 1212 Hebrew-speakers aged 5–86 years were analyzed. Both linear and curvilinear quadratic models fit the data, reflecting a general increase in ability with age, as well as an increase followed by a decrease beyond this linear rise. A significant interaction between task type and the curvilinear effect demonstrated differential lifespan patterns of performance on each task. While scores improved similarly on the phonemic and semantic tasks during childhood, late-life decline was more noticeable on the semantic task, possibly due to the unique characteristics of aging-related word retrieval difficulties. [ABSTRACT FROM PUBLISHER]