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311 results on '"Kamińska D"'

1. Psychopathological Symptoms Among Chronically Ill Patients During SARS-CoV-2 Pandemic in Poland

Author

Pawłowski M, Fila-Witecka K, Rymaszewska JE, Kamińska D, Poznański P, Augustyniak-Bartosik H, Zielińska D, Krajewska M, Krajewski PK, Stefaniak A, Szepietowski JC, Pokryszko-Dragan A, Chojdak-Łukasiewicz J, Budrewicz S, Pawłowski T, Szcześniak D, and Rymaszewska J

Subjects
pandemic, sars-cov 2, chronic kidney disease, psychopathology, multiple sclerosis, psoriasis, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Marcin Pawłowski,1 Karolina Fila-Witecka,1 Julia Ewa Rymaszewska,1 Dorota Kamińska,2 Paweł Poznański,2 Hanna Augustyniak-Bartosik,2 Dorota Zielińska,2 Magdalena Krajewska,2 Piotr K Krajewski,3 Aleksandra Stefaniak,3 Jacek C Szepietowski,3 Anna Pokryszko-Dragan,4 Justyna Chojdak-Łukasiewicz,4 Sławomir Budrewicz,4 Tomasz Pawłowski,1 Dorota Szcześniak,1 Joanna Rymaszewska1 1Psychiatry Department, Wroclaw Medical University, Wroclaw, Poland; 2Nephrology and Transplantology Department, Wroclaw Medical University, Wroclaw, Poland; 3Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland; 4Department of Neurology, Wroclaw Medical University, Wroclaw, PolandCorrespondence: Marcin Pawłowski, Email marcin.pawlowski@student.umw.edu.plIntroduction: The global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic had a drastic psychological and economic impact on the global population. Having a chronic disease during the pandemic is associated with numerous limitations and challenges like regular hospital visits, access to health-care units and getting specialized treatment. In addition, chronically ill patients are at great risk of acquiring the SARS-CoV-2 virus and at experiencing a more severe course of illness, due to comorbid conditions as well as more frequent encounters with health-care workers and other patients in medical facilities. The aim of this study was to examine the psychological disturbances, during the pandemic in chronically ill patients.Methods: During the cross-sectional survey conducted between May and October 2020, 398 patients with four different chronic conditions (psoriasis, multiple sclerosis and patients who have undergone a kidney transplant or received dialysis). Study sample was examined regarding the occurrence of psychopathological symptoms (General Health Questionnaire 28) and their perceived stress levels (Perceived Stress Scale).Results: The highest scores were found in the MS group and the lowest scores were found in the kidney transplantation group in every subscale of the GHQ-28. Close to half of the studied population (48.74%, n = 193) patients scored above the cut-off for psychopathology.Conclusion: As the study was conducted during the SARS-CoV-2 pandemic in Poland, it stands to reason that the pandemic affected the psychological wellbeing of chronically ill patients. A COVID-19 infection, being quarantined and having had contact with a person who was infected, did not significantly affect the outcome measures; however, further research is needed to explore this topic.Keywords: pandemic, SARS-CoV 2, chronic kidney disease, psychopathology, multiple sclerosis, psoriasis

Published
2022

2. Studies of discrete symmetries in a purely leptonic system using the Jagiellonian Positron Emission Tomograph

Author

Moskal P., Alfs D., Bednarski T., Białas P., Curceanu C., Czerwiński E., Dulski K., Gajos A., Głowacz B., Gupta-Sharma N., Gorgol M., Hiesmayr B. C., Jasińska B., Kamińska D., Khreptak O., Korcyl G., Kowalski P., Krzemień W., Krawczyk N., Kubicz E., Mohammed M., Niedźwiecki Sz., Pawlik-Niedńwiecka M., Raczyński L., Rudy Z., Silarski M., Smyrski J., Wieczorek A., Wiślicki W., Zgardzińska B., and Zieliński M.

Subjects
Physics, QC1-999
Abstract

Discrete symmetries such as parity (P), charge-conjugation (C) and time reversal (T) are of fundamental importance in physics and cosmology. Breaking of charge conjugation symmetry (C) and its combination with parity (CP) constitute necessary conditions for the existence of the asymmetry between matter and antimatter in the observed Universe. The presently known sources of discrete symmetries violations can account for only a tiny fraction of the excess of matter over antimatter. So far CP and T symmetries violations were observed only for systems involving quarks and they were never reported for the purely leptonic objects. In this article we describe briefly an experimental proposal for the test of discrete symmetries in the decays of positronium atom which is made exclusively of leptons. The experiments are conducted by means of the Jagiellonian Positron Emission Tomograph (J-PET) which is constructed from strips of plastic scintillators enabling registration of photons from the positronium annihilation. J-PET tomograph together with the positronium target system enable to measure expectation values for the discrete symmetries odd operators constructed from (i) spin vector of the ortho-positronium atom, (ii) momentum vectors of photons originating from the decay of positronium, and (iii) linear polarization direction of annihilation photons. Linearly polarized positronium will be produced in the highly porous aerogel or polymer targets, exploiting longitudinally polarized positrons emitted by the sodium 22Na isotope. Information about the polarization vector of orthopositronium will be available on the event by event basis and will be reconstructed from the known position of the positron source and the reconstructed position of the orthopositronium annihilation. In 2016 the first tests and calibration runs are planned, and the data collection with high statistics will commence in the year 2017.

Published
2016
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3. J-PET detector system for studies of the electron-positron annihilations

Author

Pawlik-Niedźwiecka M., Khreptak O., Gajos A., Wieczorek A., Alfs D., Bednarski T., Białas P., Curceanu C., Czerwiński E., Dulski K., Głowacz B., Gupta-Sharma N., Gorgol M., Hiesmayr B. C., Jasińska B., Kamińska D., Korcyl G., Kowalski P., Krzmień W., Krawczyk N., Kubicz E., Mohammed M., Niedźwiecki Sz., Raczyński L., Rudy Z., Silarski M., Wiślicki W., Zgardzińska B., Zieliński M., and Moskal P.

Subjects
Physics, QC1-999
Abstract

Jagiellonian Positron Emission Tomograph (J-PET) has been recently constructed at the Jagiellonian University as a prototype of a cost-effective scanner for the metabolic imaging of the whole human body. J-PET detector is optimized for the measurement of momentum and polarization of photons from the electron-positron annihilations. It is built out of strips of plastic scintillators, forming three cylindrical layers. As detector of gamma quanta it will be used for studies of discrete symmetries and multiparticle entanglement of photons originating from the decays of ortho-positronium atoms.

Published
2016
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4. Evidence from the large VALIGA cohort validates the subclassification of focal segmental glomerulosclerosis in IgA nephropathy

Author

Coppo, R., Feehaly, J., Troyanov, S., Cattran, D.C., Cook, H.T., Roberts, I., Radcliffe, John, Russo, M.L., Tesar, V., Maixnerova, D., Lundberg, S., Gesualdo, L., Emma, F., Fuiano, L., Beltrame, G., Rollino, C., Amore, A., Camilla, R., Peruzzi, L., Praga, M., Feriozzi, S., Polci, R., Segoloni, G., Colla, L., Pani, A., Piras, D., Angioi, A., Cancarini, G., Ravera, S., Durlik, M., Moggia, E., Ballarin, J., Di Giulio, S., Pugliese, F., Serriello, I., Caliskan, Y., Sever, M., Kilicaslan, I., Locatelli, F., Del Vecchio, L., Wetzels, J.F.M., Peters, H., Berg, U., Carvalho, F., da Costa Ferreira, A.C., Maggio, M., Wiecek, A., Ots-Rosenberg, M., Magistroni, R., Topaloglu, R., Bilginer, Y., D’Amico, M., Papagianni, K., Stangou, M., Giacchino, F., Goumenos, D., Papasotirious, M., Kalliakmani, P., Gerolymos, M., Galesic, K., Toric, L., Geddes, C., Siamopoulos, K., Balafa, O., Galliani, M., Stratta, P., Quaglia, M., Bergia, R., Cravero, R., Salvadori, M., Cirami, L., Fellstrom, B., Kloster Smerud, H., Ferrario, F., Stellato, T., Egido, J., Martin, C., Floege, J., Eitner, F., Lupo, A., Bernich, P., Menè, P., Morosetti, M., van Kooten, C., Rabelink, T., Reinders, M.E.J., Boria Grinyo, J.M., Cusinato, S., Benozzi, L., Savoldi, S., Licata, C., Mizerska-Wasiak, M., Roszkowska-Blaim, M., Hryszko, T., Klinger, M., Kamińska, D., Krajewska, M., Martina, G., Messuerotti, A., Dal Canton, A., Esposito, C., Migotto, C., Triolo, G., Mariano, F., Pozzi, C., Boero, R., Cambier, A., Bellur, S., Mazzucco, G., Giannakakis, C., Honsova, E., Sundelin, B., Di Palma, A.M., Diomedi-Casadei, F., Gutiérrez, E., Asunis, A.M., Barratt, J., Tardanico, R., Perkowska-Ptasinska, A., Arce Terroba, J., Fortunato, M., Pantzaki, A., Ozluk, Y., Steenbergen, E., Soderberg, M., Riispere, Z., Furci, L., Orhan, D., Kipgen, D., Casartelli, D., Galesic Ljubanovic, D., Gakiopoulou, H., Bertoni, E., Cannata Ortiz, P., Karkoszka, H., Groene, H.J., Stoppacciaro, A., Bajema, I., Bruijn, J., Fulladosa Oliveras, X., Maldyk, J., Ioachim, E., Royal, V., Bellur, Shubha S., Troyanov, Stéphan, Vorobyeva, Olga, Coppo, Rosanna, and Roberts, Ian S.D.

Published
2024
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5. Erratum to: Precision tests of quantum mechanics and CPT symmetry with entangled neutral kaons at KLOE

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D’Agostini, G., D’Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D’Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., Perez del Rio, E., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2022
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6. Precision tests of quantum mechanics and CPT symmetry with entangled neutral kaons at KLOE

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D’Agostini, G., D’Amico, R., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Diociaiuti, E., Domenici, D., D’Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V. L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E. A., Krzemien, W., Kupsc, A., Lukin, P. A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., Perez del Rio, E., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E. P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2022
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7. Measurement of gamma quantum interaction point in plastic scintillator with WLS strips

Author

Smyrski, J., Alfs, D., Bednarski, T., Białas, P., Czerwiński, E., Dulski, K., Gajos, A., Głowacz, B., Gupta-Sharma, N., Gorgol, M., Jasińska, B., Kajetanowicz, M., Kamińska, D., Korcyl, G., Kowalski, P., Krzemień, W., Krawczyk, N., Kubicz, E., Mohammed, M., Niedźwiecki, Sz., Pawlik-Niedźwiecka, M., Raczyński, L., Rudy, Z., Salabura, P., Silarski, M., Strzelecki, A., Wieczorek, A., Wiślicki, W., Wojnarska, J., Zgardzińska, B., Zieliński, M., and Moskal, P.

Published
2017
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8. Trilateration-based reconstruction of ortho-positronium decays into three photons with the J-PET detector

Author

Gajos, A., Kamińska, D., Czerwiński, E., Alfs, D., Bednarski, T., Białas, P., Głowacz, B., Gorgol, M., Jasińska, B., Kapłon, Ł., Korcyl, G., Kowalski, P., Kozik, T., Krzemień, W., Kubicz, E., Mohammed, M., Niedźwiecki, Sz., Pałka, M., Pawlik-Niedźwiecka, M., Raczyński, L., Rudy, Z., Rundel, O., Sharma, N.G., Silarski, M., Słomski, A., Strzelecki, A., Wieczorek, A., Wiślicki, W., Zgardzińska, B., Zieliński, M., and Moskal, P.

Published
2016
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9. A novel method for the line-of-response and time-of-flight reconstruction in TOF-PET detectors based on a library of synchronized model signals

Author

Moskal, P., Zoń, N., Bednarski, T., Białas, P., Czerwiński, E., Gajos, A., Kamińska, D., Kapłon, Ł., Kochanowski, A., Korcyl, G., Kowal, J., Kowalski, P., Kozik, T., Krzemień, W., Kubicz, E., Niedźwiecki, Sz., Pałka, M., Raczyński, L., Rudy, Z., Rundel, O., Salabura, P., Sharma, N.G., Silarski, M., Słomski, A., Smyrski, J., Strzelecki, A., Wieczorek, A., Wiślicki, W., and Zieliński, M.

Published
2015
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10. A feasibility study of ortho-positronium decays measurement with the J-PET scanner based on plastic scintillators

Author

Kamińska, D., Gajos, A., Czerwiński, E., Alfs, D., Bednarski, T., Białas, P., Curceanu, C., Dulski, K., Głowacz, B., Gupta-Sharma, N., Gorgol, M., Hiesmayr, B. C., Jasińska, B., Korcyl, G., Kowalski, P., Krzemień, W., Krawczyk, N., Kubicz, E., Mohammed, M., Niedźwiecki, Sz., Pawlik-Niedźwiecka, M., Raczyński, L., Rudy, Z., Silarski, M., Wieczorek, A., Wiślicki, W., Zgardzińska, B., Zieliński, M., and Moskal, P.

Published
2016
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13. Measurement of the branching fraction for the decay KS → πμν with the KLOE detector

Author

Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V.L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E.A., Krzemien, W., Kupsc, A., Lukin, P.A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Parzych, S., Passeri, A., Patera, V., Perez del Rio, E., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E.P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2020
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18. Combined limit on the production of a light gauge boson decaying into μ+μ− and π+π−

Author

Anastasi, A., Babusci, D., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Domenici, D., D'Uffizi, A., Fantini, A., Fantini, G., Fermani, P., Fiore, S., Gajos, A., Gauzzi, P., Giovannella, S., Graziani, E., Ivanov, V.L., Johansson, T., Kang, X., Kisielewska-Kamińska, D., Kozyrev, E.A., Krzemien, W., Kupsc, A., Lukin, P.A., Mandaglio, G., Martini, M., Messi, R., Miscetti, S., Moricciani, D., Moskal, P., Passeri, A., Patera, V., Perez del Rio, E., Raha, N., Santangelo, P., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Solodov, E.P., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2018
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22. Measurement of the running of the fine structure constant below 1 GeV with the KLOE detector

Author

Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Dané, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Lukin, P.A., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Papenbrock, M., Passeri, A., Patera, V., Perez del Rio, E., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Selce, A., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., Wolke, M., and Jegerlehner, F.

Published
2017
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23. Limit on the production of a new vector boson in e+e− → Uγ, U → π+π− with the KLOE experiment

Author

Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Ikegami Andersson, W., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Palladino, A., Papenbrock, M., Passeri, A., Patera, V., Perez del Rio, E., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2016
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24. Measurement of the ϕ → π0e+e− transition form factor with the KLOE detector

Author

Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Ikegami Andersson, W., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Papenbrock, M., Passeri, A., Patera, V., Perez del Rio, E., Ranieri, A., Salabura, P., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2016
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27. Limit on the production of a low-mass vector boson in [formula omitted], [formula omitted] with the KLOE experiment

Author

Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Ikegami Andersson, W., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Palladino, A., Papenbrock, M., Passeri, A., Patera, V., Perez del Rio, E., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2015
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28. Search for dark Higgsstrahlung in e+e− → μ+μ− and missing energy events with the KLOE experiment

Author

Anastasi, A., Babusci, D., Bencivenni, G., Berlowski, M., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Cao, B., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., D'Agostini, G., Danè, E., De Leo, V., De Lucia, E., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., D'Uffizi, A., Fantini, A., Felici, G., Fiore, S., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Ikegami Andersson, W., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Loffredo, S., Mandaglio, G., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Nguyen, F., Palladino, A., Passeri, A., Patera, V., Perez del Rio, E., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Silarski, M., Sirghi, F., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2015
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29. Study of the Dalitz decay ϕ → ηe+e− with the KLOE detector

Author

Babusci, D., Balwierz-Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., Danè, E., De Leo, V., De Lucia, E., De Robertis, G., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, S., Franzini, P., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Höistad, B., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Lee-Franzini, J., Loddo, F., Loffredo, S., Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Palladino, A., Passeri, A., Patera, V., Prado Longhi, I., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2015
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30. Measurement of the absolute branching ratio of the [formula omitted] decay with the KLOE detector

Author

Babusci, D., Balwierz-Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., Danè, E., De Leo, V., De Lucia, E., De Robertis, G., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, S., Franzini, P., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Höistad, B., Johansson, T., Kamińska, D., Krzemien, W., Kupsc, A., Lee-Franzini, J., Loddo, F., Loffredo, S., Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Palladino, A., Passeri, A., Patera, V., Prado Longhi, I., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Tortora, L., Venanzoni, G., Wiślicki, W., and Wolke, M.

Published
2014
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31. Search for light vector boson production in [formula omitted] interactions with the KLOE experiment

Author

Babusci, D., Balwierz-Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., Danè, E., De Leo, V., De Lucia, E., De Robertis, G., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Salvo, R., Domenici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, S., Franzini, P., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Höistad, B., Johansson, T., Kacprzak, K., Kamińska, D., Krzemien, W., Kupsc, A., Lee-Franzini, J., Loddo, F., Loffredo, S., Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Nguyen, F., Palladino, A., Passeri, A., Patera, V., Prado Longhi, I., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Tortora, L., Venanzoni, G., Wiślicki, W., Wolke, M., and Zdebik, J.

Published
2014
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32. Test of CPT and Lorentz symmetry in entangled neutral kaons with the KLOE experiment

Author

Babusci, D., Balwierz-Pytko, I., Bencivenni, G., Bloise, C., Bossi, F., Branchini, P., Budano, A., Caldeira Balkeståhl, L., Capon, G., Ceradini, F., Ciambrone, P., Curciarello, F., Czerwiński, E., Danè, E., De Leo, V., De Lucia, E., De Robertis, G., De Santis, A., De Simone, P., Di Cicco, A., Di Domenico, A., Di Donato, C., Di Salvo, R., Domenici, D., Erriquez, O., Fanizzi, G., Fantini, A., Felici, G., Fiore, S., Franzini, P., Gajos, A., Gauzzi, P., Giardina, G., Giovannella, S., Graziani, E., Happacher, F., Heijkenskjöld, L., Höistad, B., Jacewicz, M., Johansson, T., Kacprzak, K., Kamińska, D., Kupsc, A., Lee-Franzini, J., Loddo, F., Loffredo, S., Mandaglio, G., Martemianov, M., Martini, M., Mascolo, M., Messi, R., Miscetti, S., Morello, G., Moricciani, D., Moskal, P., Nguyen, F., Palladino, A., Passeri, A., Patera, V., Prado Longhi, I., Ranieri, A., Santangelo, P., Sarra, I., Schioppa, M., Sciascia, B., Silarski, M., Taccini, C., Tortora, L., Venanzoni, G., Wiślicki, W., Wolke, M., and Zdebik, J.

Published
2014
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34. Pretransplant Immune Interplay Between Donor and Recipient Influences Posttransplant Kidney Allograft Function.

Author

Kamińska, D., Kościelska-Kasprzak, K., Mazanowska, O., Żabińska, M., Bartoszek, D., Banasik, M., Chudoba, P., Lepiesza, A., Gomułkiewicz, A., Dzięgiel, P., Krajewska, M., Polak, W., and Klinger, M.

Subjects
*KIDNEY transplantation, *HOMOGRAFTS, *ORGAN donors, *IMMUNOLOGIC diseases, *UREMIA, *BRAIN death
Abstract

Background Renal transplant candidates present immune dysregulation caused by chronic uremia, and deceased kidney donors present immune activation induced by brain death. Pretransplant donor and recipient immune-related gene expression were examined in the search for novel predictive biomarkers crosslinking recipient and donor pretransplant immune status with transplant outcome. Materials and methods This study included 33 low-risk consecutive renal transplant recipients and matched deceased donors. The expression of 29 genes linked to tissue injury, T-cell activation, cell migration, and apoptosis were assessed in postreperfusion kidney biopsies, as well as 14 genes in pretransplant peripheral blood of the kidney recipients. Gene expression was analyzed with real-time polymerase chain reaction on custom-designed low-density arrays. Results Donor MMP9 expression was related to delayed graft function occurrence ( P = .036) and short term kidney allograft function (14th day r s = −0.44, P = .012; 1st month r s = −0.46, P = .013). Donor TGFB1 expression was associated with short- and long-term graft function (14th day r s = −0.47, P = .007; 3rd month r s = −0.63, P = .001; 6th month r s = −0.52, P = .010; 12th month r s = −0.45, P = .028; 24th month r s = −0.64, P = .003). Donor TGFB1 expression was not related to donor age ( r s = 0.32, P = .081), which was also an independent factor influencing the outcome. Recipient gene expression was not related to graft function but determined the acute rejection risk. Recipient IFNG and, to a lesser extent, IL18 expression were protective against acute rejection (area under the curve [AUC] 0.84, P < .001, and AUC 0.79, P < .001, respectively). Conclusion Kidney transplant outcome depends on the interplay between donor-related immune factors, which mostly affect allograft function and recipient immune milieu, influencing an alloreactive response. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Analysis Procedure of the Positronium Lifetime Spectra for the J-PET Detector.

Author

DULSKI, K., ZGARDZIŃSKA, B., BIAŁAS, P., CURCEANU, C., CZERWIŃSKI, E., GAJOS, A., GŁOWACZ, B., GORGOL, M., HIESMAYR, B. C., JASIŃSKA, B., KISIELEWSKA-KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., KRAWCZYK, N., KRZEMIEŃ, W., KUBICZ, E., MOHAMMED, MUHSIN, PAWLIK-NIEDŹWIECKA, M., and NIEDŹWIECKI, S.

Subjects
POSITRON annihilation, RADIOPHARMACEUTICALS, MAGNETIC resonance imaging, QUANTUM theory, ION beams
Abstract

Positron annihilation lifetime spectroscopy has shown to be a powerful tool to study the nanostructures of porous materials. Positron emission tomograph is a device allowing imaging of metabolic processes e.g. in human bodies. A newly developed device, the Jagiellonian PET will allow positron annihilation lifetime spectroscopy in addition to imaging, thus combining both analyses providing new methods for physics and medicine. In this contribution we present a computer program that is compatible with the Jagiellonian PET software. We compare its performance with the standard program LT 9.0 by using positron annihilation lifetime spectroscopy data from hexane measurements at different temperatures. Our program is based on an iterative procedure, and our fits prove that it performs as good as LT 9.0. [ABSTRACT FROM AUTHOR]

Published
2017
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38. Time Calibration of the J-PET Detector.

Author

SKURZOK, M., SILARSKI, M., ALFS, D., BIAŁAS, P., SHIVANI, CURCEANU, C., CZERWIŃSKI, E., DULSKI, K., GAJOS, A., GŁOWACZ, B., GORGOL, M., HIESMAYR, B. C., JASIŃSKA, B., KISIELEWSKA-KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., KRAWCZYK, N., KRZEMIEŃ, W., and KUBICZ, E.

Subjects
POSITRON emission tomography, RADIOPHARMACEUTICALS, POSITRON annihilation, COMPUTED tomography, SPECTRUM analysis
Abstract

The Jagiellonian positron emission tomograph project carried out in the Institute of Physics of the Jagiellonian University is focused on construction and tests of the first prototype of PET scanner for medical diagnostic which allows for the simultaneous 3D imaging of the whole human body using organic scintillators. The J-PET prototype consists of 192 scintillator strips forming three cylindrical layers which are optimized for the detection of photons from the electron-positron annihilation with high time-and high angular resolutions. In this article we present time calibration and synchronization of the whole J-PET detection system by irradiating each single detection module with a 22Na source and a small detector providing common reference time for synchronization of all the modules. [ABSTRACT FROM AUTHOR]

Published
2017
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39. THREE-DIMENSIONAL IMAGE RECONSTRUCTION IN J-PET USING FILTERED BACK-PROJECTION METHOD.

Author

SHOPA, R. Y., KLIMASZEWSKI, K., KOWALSKI, P., KRZEMIEŃ, W., RACZYŃSKI, L., WIŚLICKI, W., BIAŁAS, P., CURCEANU, C., CZERWIŃSKI, E., DULSKI, K., GAJOS, A., GŁOWACZ, B., GORGOL, M., HIESMAYR, B., JASIŃSKA, B., KISIELEWSKA-KAMIŃSKA, D., KORCYL, G., KOZIK, T., KRAWCZYK, N., and KUBICZ, E.

Subjects
IMAGE reconstruction, POSITRON emission tomography, IMAGE processing, INTERPOLATION algorithms, IMAGING systems
Abstract

We present a method and preliminary results of the image reconstruction in the Jagiellonian PET tomograph. Using GATE (Geant4 Application for Tomographic Emission), interactions of the 511 keV photons with a cylindrical detector were generated. Pairs of such photons, flying backto- back, originate from e+e- annihilations inside a 1 mm spherical source. Spatial and temporal coordinates of hits were smeared using experimental resolutions of the detector. We incorporated the algorithm of the 3D Filtered Back Projection, implemented in the STIR and TomoPy software packages, which differ in approximation methods. Consistent results for the Point Spread Functions of ~ 5÷7 mm and ~ 9÷20 mm were obtained, using STIR, for transverse and longitudinal directions, respectively, with no time-of-flight information included. [ABSTRACT FROM AUTHOR]

Published
2017
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40. HUMAN TISSUES INVESTIGATION USING PALS TECHNIQUE.

Author

JASIŃSKA, B., ZGARDZIŃSKA, B., CHOŁUBEK, G., PIETROW, M., GORGOL, M., WYSOGLĄD, K., WIKTOR, H., WIKTOR, K., BIAŁAS, P., CURCEANU, C., CZERWIŃSKI, E., DULSKI, K., GAJOS, A., GŁOWACZ, B., HIESMAYR, B., KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., and KRAWCZYK, N.

Subjects
ANNIHILATION reactions, POSITRON annihilation, POSITRONIUM, TISSUE analysis, RADIONUCLIDE imaging
Abstract

Samples of uterine leiomyomatis and normal tissues taken from patients after surgery were investigated using the Positron Annihilation Lifetime Spectroscopy (PALS). Significant differences in all PALS parameters between normal and diseased tissues were observed. For all studied patients, it was found that the values of the free annihilation and orthopositronium lifetime are larger for the tumorous tissues than for the healthy ones. For most of the patients, the intensity of the free annihilation and ortho-positronium annihilation was smaller for the tumorous than for the healthy tissues. For the first time, in this kind of studies, the 3γfraction of positron annihilation was determined to describe changes in the tissue porosity during morphologic alteration. [ABSTRACT FROM AUTHOR]

Published
2017
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41. INTRODUCTION OF TOTAL VARIATION REGULARIZATION INTO FILTERED BACKPROJECTION ALGORITHM.

Author

RACZYŃSKI, L., WIŚLICKI, W., KLIMASZEWSKI, K., KRZEMIEŃ, W., SHOPA, R.Y., BIAŁAS, P., CURCEANU, C., CZERWINSKI, E., DULSKI, K., GAJOS, A., GŁOWACZ, B., GORGOL, M., HIESMAYR, B., JASIŃSKA, B., KISIELEWSKA-KAMIŃSKA, D., KORCYL, G., KOZIK, T., KRAWCZYK, N., KUBICZ, E., and MOHAMMED, M.

Subjects
FILTERED rings, IMAGE reconstruction, RADIOACTIVE tracers, REGRESSION analysis, DIAGNOSTIC imaging
Abstract

In this paper, we extend the state-of-the-art filtered backprojection (FBP) method with application of the concept of Total Variation regularization. We compare the performance of the new algorithm with the most common form of regularizing in the FBP image reconstruction via apodizing functions. The methods are validated in terms of cross-correlation coefficient between reconstructed and real image of radioactive tracer distribution using the standard Derenzo-type phantom. We demonstrate that the proposed approach results in higher cross-correlation values with respect to the standard FBP method. [ABSTRACT FROM AUTHOR]

Published
2017
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43. OVERVIEW OF THE SOFTWARE ARCHITECTURE AND DATA FLOW FOR THE J-PET TOMOGRAPHY DEVICE.

Author

KRZEMIEŃ, W., ALFS, D., BIAŁAS, P., CZERWIŃSKI, E., GAJOS, A., GŁOWACZ, B., JASIŃSKA, B., KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., KUBICZ, E., NIEDŹWIECKI, SZ., PAWLIK-NIEDŹWIECKA, M., RACZYŃSKI, L., RUDY, Z., SILARSKI, M., STRZELECKI, A., WIECZOREK, A., and WIřLICKI, W.

Subjects
SCANNING systems, IMAGING systems, INFORMATION storage & retrieval systems, IMAGE reconstruction, DATA flow computing
Abstract

Modern TOF-PET scanner systems require high-speed computing resources for efficient data processing, monitoring and image reconstruction. In this article, we present the data flow and software architecture for the novel TOF-PET scanner developed by the J-PET Collaboration. We discuss the data acquisition system, reconstruction framework and image reconstruction software. Also, the concept of computing outside hospitals in the remote centers such as Świerk Computing Centre in Poland is presented. [ABSTRACT FROM AUTHOR]

Published
2016
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44. BEAM PROFILE INVESTIGATION OF THE NEW COLLIMATOR SYSTEM FOR THE J-PET DETECTOR.

Author

KUBICZ, E., SILARSKI, M., WIECZOREK, A., ALFS, D., BEDNARSKI, T., BIAŁAS, P., CZERWIŃSKI, E., GAJOS, A., GŃOWACZ, B., JASIŃSKA, B., KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., KRZEMIEŃ, W., MOHAMMED, M., MOSKAL, I., NIEDŹWIECKI, S., PAWLIK-NIEDŹWIECKA, M., and RACZYńSKI, L.

Subjects
POSITRON emission, POSITRON emission tomography, DISCRETE symmetries, BEAM collimation, COLLIMATORS
Abstract

Jagiellonian Positron Emission Tomograph (J-PET) is a multi-purpose detector which will be used for search for discrete symmetries violations in the decays of positronium atoms and for investigations with positronium atoms in life-sciences and medical diagnostics. In this article, we present three methods for determination of the beam profile of collimated annihilation gamma quanta. Precise monitoring of this profile is essential for time and energy calibration of the J-PET detector and for the determination of the library of model signals used in the hit-time and hit-position reconstruction. We have shown that usage of two lead bricks with dimensions of 5 × 10 × 20 cm3 enables to form a beam of annihilation quanta with Gaussian profile characterized by 1 mm FWHM. Determination of this characteristic is essential for designing and construction the collimator system for the 24-module J-PET prototype. Simulations of the beam profile for different collimator dimensions were performed. This allowed us to choose optimal collimation system in terms of the beam profile parameters, dimensions and weight of the collimator taking into account the design of the 24-module J-PET detector. [ABSTRACT FROM AUTHOR]

Published
2016
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45. POTENTIAL OF THE J-PET DETECTOR FOR STUDIES OF DISCRETE SYMMETRIES IN DECAYS OF POSITRONIUM ATOM -- A PURELY LEPTONIC SYSTEM.

Author

MOSKAL, P., ALFS, D., BEDNARSKI, T., BIAŁAS, P., CZERWIŃSKI, E., CURCEANU, C., GAJOS, A., GŁOWACZ, B., GORGOL, M., HIESMAYR, B. C., JASIŃSKA, B., KAMIŃSKA, D., KORCYL, G., KOWALSKI, P., KOZIK, T., KRZEMIEŃ, W., KRAWCZYK, N., KUBICZ, E., MOHAMMED, M., and NIEDŹWIECKI, SZ.

Subjects
POSITRON emission, POSITRON emission tomography, SCANNING systems, ELECTRON-positron interactions, LEPTON interactions
Abstract

The Jagiellonian Positron Emission Tomograph (J-PET) was constructed as a prototype of the cost-effective scanner for the simultaneous metabolic imaging of the whole human body. Being optimized for the detection of photons from the electron-positron annihilation with high time- and high angular-resolution, it constitutes a multi-purpose detector providing new opportunities for studying the decays of positronium atoms. Positronium is the lightest purely leptonic object decaying into photons. As an atom bound by a central potential, it is a parity eigenstate, and as an atom built out of an electron and an anti-electron, it is an eigen- state of the charge conjugation operator. Therefore, the positronium is a unique laboratory to study discrete symmetries whose precision is limited, in principle, by the effects due to the weak interactions expected at the level of (~ 10-14) and photon-photon interactions expected at the level of (~ 10-9). The J-PET detector enables to perform tests of discrete symmetries in the leptonic sector via the determination of the expectation values of the discrete-symmetries-odd operators, which may be constructed from the spin of ortho-positronium atom and the momenta and polarization vectors of photons originating from its annihilation. In this article, we present the potential of the J-PET detector to test the C, CP, T and CPT symmetries in the decays of positronium atoms. [ABSTRACT FROM AUTHOR]

Published
2016
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46. SCATTER FRACTION OF THE J-PET TOMOGRAPHY SCANNER.

Author

KOWALSKI, P., WIřLICKI, W., RACZYŃSKI, L., BEDNARSKI, D. ALFSB T., BIAŁAS, P., CZERWIŃSKI, E., GAJOS, A., GŁOWACZ, B., JASIŃSKA, J., KAMIŃSKA, D., KORCYL, G., KOZIK, T., KRZEMIEŃ, W., KUBICZ, E., MOHAMMAD, M., NIEDźWIECKI, SZ., PAłKA, M., PAWLIK-NIEDźWIECKA, M., RUDY, Z., and SILARSKI, M.

Subjects
POSITRON emission tomography, SCINTILLATORS, DETECTORS, MULTIPLE scattering (Physics), POSITRONS
Abstract

A novel Positron Emission Tomography system, based on plastic scintillators, is being developed by the J-PET Collaboration. In this article, we present the simulation results of the scatter fraction, representing one of the parameters crucial for background studies defined in the NEMA-NU-2- 2012 norm. We elaborate an event selection methods allowing to suppress events in which gamma quanta were scattered in the phantom or underwent the multiple scattering in the detector. The estimated scatter fraction for the single-layer J-PET scanner varies from 37% to 53% depending on the applied energy threshold. [ABSTRACT FROM AUTHOR]

Published
2016
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47. SAMPLING FEE AND TRIGGER-LESS DAQ FOR THE J-PET SCANNER.

Author

KORCYL, G., ALFS, D., BEDNARSKI, T., BIAŁAS, P., CZERWIŃSKI, E., DULSKI, K., GAJOS, A., GŁOWACZ, B., JASIŃSKA, B., KAMIŃSKA, D., KAPŁON, Ł., KOWALSKI, P., KOZIK, T., KRZEMIEŃ, W., KUBICZ, E., MOHAMME, M., NIEDŹWIECKI, SZ., PAŁKA, M., PAWLIK-NIEDŹWIECKA, M., and RACZYŃSKI, L.

Subjects
DATA acquisition systems, INFORMATION storage & retrieval systems, SCANNING systems, OPTICAL transceivers, DATA recorders & recording
Abstract

In this paper, we present a complete Data Acquisition System (DAQ) together with the readout mechanisms for the J-PET tomography scanner. In general, detector readout chain is constructed out of Front-End Electronics (FEE) measurement devices such as Time-to-Digital or Analog-to- Digital Converters (TDCs or ADCs), data collectors and storage. We have developed a system capable for maintaining continuous readout of digitized data without preliminary selection. Such operation mode results in up to 8 Gbps data stream, therefore, it is required to introduce a dedicated module for on-line event building and feature extraction. The Central Controller Module, equipped with Xilinx Zynq SoC and 16 optical transceivers, serves as such true real time computing facility. Our solution for the continuous data recording (trigger-less) is a novel approach in such detector systems and assures that most of the information is preserved on the storage for further, high-level processing. Signal discrimination applies a unique method of using LVDS buffers located in the FPGA fabric. [ABSTRACT FROM AUTHOR]

Published
2016
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48. DETERMINATION OF THE 3γ FRACTION FROM POSITRON ANNIHILATION IN MESOPOROUS MATERIALS FOR SYMMETRY VIOLATION EXPERIMENT WITH J-PET SCANNER.

Author

JASIŃSKA, B., GORGOL, M., WIERTEL, M., ZALESKI, R., ALFS, D., BEDNARSKI, T., BIAŁAS, P., CZERWIŃSKI, E., GAJOS, K. DULSKIB A., GŁOWACZ, B., KAMIŃSKA, D., KAPŁON, Ł., KORCYL, G., KOWALSKI, P., KOZIK, T., KRZEMIEŃ, W., KUBICZ, E., MOHAMMED, M., NIEDŹWIECKI, SZ., and PAŁKA, M.

Subjects
POSITRON annihilation, ANNIHILATION reactions, MESOPOROUS materials, SYMMETRY (Physics), POLYMERS, ELECTRON microscopes, SPECTROSCOPE
Abstract

Various mesoporous materials were investigated to choose the best material for experiments requiring high yield of long-lived positronium. We found that the fraction of 3γ annihilation determined using γ-ray energy spectra and positron annihilation lifetime spectra (PAL) changed from 20% to 25%. The 3γ fraction and o-Ps formation probability in the polymer XAD-4 is found to be the largest. Elemental analysis performed using scanning electron microscope (SEM) equipped with energy-dispersive X-ray spectroscope EDS shows high purity of the investigated materials. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Issues of Immunological and Hemodynamic Monitoring Before and During Kidney Transplantation in Sensitized Heart Transplant Recipient.

Author

Kamińska, D., Łukaszewski, M., Kozera, N., Kościelska-Kasprzak, K., Bartoszek, D., Mazanowska, O., Goździk, W., Chudoba, P., Zaleska, P., Lepiesza, A., and Klinger, M.

Subjects
*KIDNEY transplantation, *HEART transplant recipients, *HEMODYNAMICS, *ARTERIOVENOUS fistula, *HEMODIALYSIS
Abstract

Previously transplanted highly sensitized patients experience problems with subsequent transplantation. It is also difficult to provide optimal hemodynamic conditions during successive kidney transplantation in heart transplant recipients. Patient and methods We present a case of a 56-year old patient with end-stage renal failure after heart transplantation performed 21 years ago and hemodialyzed using arteriovenous fistula. The patient had 69% panel-reactive antibodies, had been on the active waiting list since 2013, and presented 335 positive crossmatches with deceased donors. He also positively crossmatched with a potential living donor. Detailed examination of anti-HLA antibodies revealed the absence of IgG donor-specific antibodies and negative crossmatch with dithiothreitol-treated serum. The transplantation from his wife was performed with positive crossmatch after 4 plasma exchanges and thymoglobulin induction. Because sympathetic and parasympathetic denervation of the transplanted heart and the presence of arteriovenous fistula induced volume overload of the right heart, we used central venous pressure (CVP) and the PiCCO2 for postsurgical assessment of cardiac output. Results Monitoring, like CVP and other static exponents of preload obtained by PICCO (extravascular lung water, global end-diastolic volume index) as well as the dynamic parameters obtained by PiCCO2 (pulse pressure variation, stroke volume variation), was not sensitive enough to describe recipient volume status. The immediate graft function was observed, and after 11 months satisfactory estimated glomerular filtration rate is noted with the absence of donor-specific antibodies. Conclusion The history of heart transplantation with existing arteriovenous fistula makes clinical tools such as continuous cardiac output monitoring and CVP parameter inadequate for describing the hemodynamic situation. The high level of panel-reactive antibodies and positive crossmatch possibly caused by IgM antibodies do not have to withdraw the recipient from kidney transplantation. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Microbiological quality of non-sterile pharmaceutical products.

Author

Ratajczak, M., Kubicka, M. M., Kamińska, D., Sawicka, P., and Długaszewska, J.

Abstract

In microbiological terms, pharmaceutical products can be divided into two groups: sterile and non-sterile. Non-sterile drugs must satisfy the appropriate microbiological purity criteria which are included in pharmacopoeial monographs. Pharmacopoeial studies are prepared specifically with a view to ensuring that the medicinal product is therapeutically effective and safe for the patient. The analysis comprised the results of microbiological purity tests performed before the products are marketed. Total of 1285 samples of non-sterile drugs manufactured by different pharmaceutical plants in Polish were taken into study. The microbiological quality of drugs was assessed in accordance with the criteria included in the European Pharmacopoeia (EP). An analysis of test results demonstrated that the percentage of non-compliant samples was 1.87%. The groups of drugs, which the most often did not satisfy EPs' requirements, were drugs containing raw materials of natural origin (5.7%). The samples of studied drugs that did not meet the criteria contained in EP, exceed the maximum allowable microbiological count limits and contained microbes whose presence is prohibited. The most common non-compliance was the excessive levels of the maximum acceptable fungal count (n= 12) and the excessive the maximum acceptable aerobic microbial count (n= 10). [ABSTRACT FROM AUTHOR]

Published
2015
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