Objective Examining pain-related activity patterns in patients with knee osteoarthritis (OA) will help to establish appropriate rehabilitation programs in this patient population. The aim of this study is to compare symptoms, pain intensity, fear of movement, anxiety, depression status and physical activities according to pain-related activity patterns in patients with knee OA. Material and Method 120 participants with clinical and radiological knee OA were included in this cross-sectional study. Participants with knee OA were divided into three groups according to the Pain-Activity Patterns Scale: avoidance pattern, overdoing pattern, and regulation pattern. Visual Analogue Scale for assessing the severity of pain of participants with knee OA, KOOS (Knee Injury and Osteoarthritis Outcome Score) for assessing knee functions and knee-related quality of life, International Physical Activity Questionnaire Short Form (IPAQ-Short) for assessing physical activity level, fear of falling the TAMPA kinesiophobia scale and the Hospital Anxiety Depression Scale (HAD) for anxiety and depression were used. Results In our study, participants with knee OA were divided into three groups according to pain, and all subgroups of pain duration, pain severity (rest-activity), and KOOS scores were found to be similar to each other (p>0.05). HAD-anxiety and depression states, TAMPA scores and IPAQ-Walking scores were found to be different between the groups (p<0.05). It was found that patients with exaggeration pattern had higher anxiety than other groups (p<0.05), patients with avoidance pattern had higher depression (p<0.05) and fear of falling (p<0.05), and patients with regulation pattern had lower walking scores (p<0.05). Conclusion According to our study, it is seen that the level of depression and anxiety is lower in ordering behavior and it is associated with positive psychosocial outcomes. However, it is seen that the level of physical activity is the lowest in patients with knee OA who exhibit regulation behavior. [ABSTRACT FROM AUTHOR]