33 results on '"Körner, Philipp"'
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2. A laboratory pilot study on voids in flowable bulk-fill composite restorations in bovine Class-II and endodontic access cavities after sonic vibration
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Körner, Philipp, Gerber, Sandra C., Gantner, Cindy, Hamza, Blend, Wegehaupt, Florian J., Attin, Thomas, and Deari, Shengjile
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- 2023
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3. Validation of ERA5-Land temperature and relative humidity on four Peruvian glaciers using on-glacier observations
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Bonshoms, Martí, Ubeda, Jose, Liguori, Giovanni, Körner, Philipp, Navarro, Álvaro, and Cruz, Rolando
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- 2022
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4. Effect of the toothbrush tuft arrangement and bristle stiffness on the abrasive dentin wear
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Hamza, Blend, Niedzwiecki, Maria, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian J.
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- 2022
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5. Integrating formal specifications into applications: the ProB Java API
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Körner, Philipp, Bendisposto, Jens, Dunkelau, Jannik, Krings, Sebastian, and Leuschel, Michael
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- 2021
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6. REAL-Fog part 2: A novel approach to calculate high resoluted spatio-temporal fog deposition: A daily fog deposition data set for entire Germany for 1949–2018
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Körner, Philipp, Kronenberg, Rico, Gliksman, Daniel, and Bernhofer, Christian
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- 2021
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7. Validation and real-life demonstration of ETCS hybrid level 3 principles using a formal B model
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Hansen, Dominik, Leuschel, Michael, Körner, Philipp, Krings, Sebastian, Naulin, Thomas, Nayeri, Nader, Schneider, David, and Skowron, Frank
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- 2020
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8. Effect of dentin pretreatment on the resulting abrasive dentin wear
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Hamza, Blend, Kazimi, Marina, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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- 2021
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9. Potential of different fluoride gels to prevent erosive tooth wear caused by gastroesophageal reflux
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Körner, Philipp, Georgis, Luca, Wiedemeier, Daniel B., Attin, Thomas, and Wegehaupt, Florian J.
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- 2021
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10. Correction to: Effect of dentin pretreatment on the resulting abrasive dentin wear
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Hamza, Blend, Kazimi, Marina, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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- 2021
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11. Demineralized enamel reduces margin integrity of self-etch, but not of etch-and-rinse bonded composite restorations
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Körner, Philipp, Sulejmani, Aljmedina, Wiedemeier, Daniel B., Attin, Thomas, and Tauböck, Tobias T.
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- 2019
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12. Erosive tooth wear among athletes.
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Attin, Thomas, Körner, Philipp, and Wegehaupt, Florian
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TOOTH erosion ,ATHLETES ,SODIUM hypochlorite ,TOOTH abrasion ,GASTROESOPHAGEAL reflux ,DENTAL enamel ,BRUXISM ,EATING disorders - Abstract
The following article deals with various considerations concerning the frequently observed occurrence of dental erosion in athletes. It summarizes the basics of erosive tooth wear development as well as special etiologic factors for groups of athletes with increased prevalence of dental erosion and concludes with preventive advice. [ABSTRACT FROM AUTHOR]
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- 2021
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13. Patient-reported symptoms during radiotherapy: Clinically relevant symptom burden in patients treated with palliative and curative intent
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Körner, Philipp, Ehrmann, Katja, Hartmannsgruber, Johann, Metz, Michaela, Steigerwald, Sabrina, Flentje, Michael, and van Oorschot, Birgitt
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- 2017
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14. Erosive/Abrasive Enamel Wear While Using a Combination of Anti-Erosive Toothbrush/-Paste.
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Körner, Philipp, Inauen, Deborah S., Attin, Thomas, and Wegehaupt, Florian J.
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ANIMALS ,CATTLE ,DENTAL enamel ,DENTIFRICES ,TOOTH abrasion ,TOOTH care & hygiene ,TOOTH erosion - Abstract
Purpose: To investigate dental enamel wear caused by erosion and abrasion while using a combination of anti-erosive toothbrush/-paste.Materials and Methods: A total of 60 enamel specimens from bovine incisors were randomly assigned into five groups of 12 specimens each (G1-5, n = 12): (G1) control group (no treatment), (G2) standard medium toothbrush Paro M43 and standard toothpaste Elmex Caries Protection, (G3) standard medium toothbrush Paro M43 and anti-erosive toothpaste Elmex Protection Erosion, (G4) anti-erosive toothbrush Elmex Erosion Soft and standard toothpaste Elmex Caries Protection, (G5) anti-erosive toothbrush Elmex Erosion Soft and anti-erosive toothpaste Elmex Protection Erosion. Initially, surface baseline profiles were recorded using profilometry. In a total of 60 cycles, all specimens were exposed to hydrochloric acid (pH = 3) for 1 min, rinsed with tap water to stop the erosive attack and brushed according to the specific protocol of each group (15 brushing strokes per run). Enamel loss was determined by comparing the surface profiles before and after 60 cycles and the results were statistically analysed using analysis of variance (ANOVA).Results: The significantly highest loss of enamel was observed in the control group G1(1.4 ± 0.20 µm) (p < 0.001). G2 turned out to be the most abrasive toothbrush/-paste combination (1.12 ± 0.15 µm), G3 the least invasive (0.40 ± 0.04 µm) (p < 0.001, respectively).Conclusion: All combinations of the investigated toothbrushes/-pastes reduce erosive/abrasive enamel wear. However, the highest reduction was observed for the combination of anti-erosive toothpaste and standard toothbrush (G3). [ABSTRACT FROM AUTHOR]- Published
- 2020
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15. Effect of brushing force on the abrasive dentin wear using slurries with different abrasivity values.
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Hamza, Blend, Martinola, Laura, Körner, Philipp, Gubler, Andrea, Attin, Thomas, and Wegehaupt, Florian Just
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DENTIFRICES ,STATISTICS ,DENTIN ,TOOTH abrasion ,CATTLE ,TOOTH care & hygiene ,INCISORS ,ANIMAL experimentation ,DESCRIPTIVE statistics ,DATA analysis ,DATA analysis software ,DISEASE risk factors - Abstract
Objective: The aim of this study was to investigate the resulting abrasive dentin wear using abrasive slurries with different RDA values and applying increasing brushing forces. Methods: Forty‐five bovine incisors were randomly allocated in three groups (A, B, C, n = 15). One hundred and eighty dentin samples were prepared from these incisors and allocated to twelve groups (A1‐A4, B1‐B4, C1‐C4; n = 15). The groups were subjected to a brushing cycle (120 strokes/min, 25 min) as follows: groups A1 to A4 with an abrasive slurry (RDA = 71) applying increasing brushing forces (1, 2, 3 and 4 N). Groups B1 to B4 were brushed using an abrasive slurry (RDA = 85) and C1 to C4 (RDA = 133) applying the same above‐mentioned brushing forces. Abrasive dentin wear was recorded using a stylus profilometer and compared amongst the groups using robust models. Pairwise comparisons in each model were tested and corrected after Tukey's method (α = 0.05). Results: Applying 1‐N brushing force resulted in the same amount of abrasive dentin wear in all groups regardless of the abrasivity of the used slurry. Increasing the brushing force to 2 N resulted in statistically significantly higher abrasive wear in all groups. This increase in abrasive wear was much higher when the slurry with high abrasivity was used (RDA = 133) compared with the lower abrasive slurry (RDA = 71). Conclusion: The abrasivity of the used slurry does not add to the resulting abrasive wear when the brushing force is kept at 1 N. It seems better to advise and help the patients (showing signs of non‐carious cervical lesions) calibrating their brushing force to 1 N, than only to advise them to use toothpastes with lower abrasivities. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Fifty Years of Prolog and Beyond.
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KÖRNER, PHILIPP, LEUSCHEL, MICHAEL, BARBOSA, JOÃO, COSTA, VÍTOR SANTOS, DAHL, VERÓNICA, HERMENEGILDO, MANUEL V., MORALES, JOSE F., WIELEMAKER, JAN, DIAZ, DANIEL, ABREU, SALVADOR, and CIATTO, GIOVANNI
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LOGIC programming ,PROGRAMMING languages ,SWOT analysis ,LEARNING - Abstract
Both logic programming in general and Prolog in particular have a long and fascinating history, intermingled with that of many disciplines they inherited from or catalyzed. A large body of research has been gathered over the last 50 years, supported by many Prolog implementations. Many implementations are still actively developed, while new ones keep appearing. Often, the features added by different systems were motivated by the interdisciplinary needs of programmers and implementors, yielding systems that, while sharing the "classic" core language, in particular, the main aspects of the ISO-Prolog standard, also depart from each other in other aspects. This obviously poses challenges for code portability. The field has also inspired many related, but quite different languages that have created their own communities. This article aims at integrating and applying the main lessons learned in the process of evolution of Prolog. It is structured into three major parts. First, we overview the evolution of Prolog systems and the community approximately up to the ISO standard, considering both the main historic developments and the motivations behind several Prolog implementations, as well as other logic programming languages influenced by Prolog. Then, we discuss the Prolog implementations that are most active after the appearance of the standard: their visions, goals, commonalities, and incompatibilities. Finally, we perform a SWOT analysis in order to better identify the potential of Prolog and propose future directions along with which Prolog might continue to add useful features, interfaces, libraries, and tools, while at the same time improving compatibility between implementations. [ABSTRACT FROM AUTHOR]
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- 2022
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17. Effect of tapered-end and round-end bristles on the abrasive dentine wear applying increasing brushing forces.
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Hamza, Blend, Svellenti, Leonardo, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian J.
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FRETTING corrosion ,TOOTHBRUSHES ,TOOTH abrasion ,TWO-way analysis of variance ,STANDARD deviations ,PATIENT safety ,DENTIN - Abstract
To investigate the effect of toothbrush bristles end configuration on the abrasive dentine wear at different brushing forces. One hundred and sixty bovine dentine samples were randomized into eight groups (n = 20). Groups (1 to 4) were brushed with tapered-end bristles at 1-, 2-, 3-, and 4-N brushing forces, respectively. Groups (5 to 8) were brushed with round-end bristles with the same brushing forces. The brushing sequence was carried out using an abrasive slurry (RDA = 121) for 25 min. Profiles were recorded using a contact profilometer. Mean and standard deviation were calculated for the abrasive dentine wear in each group. Two-way ANOVA was used to locate any significance. The significance values were corrected after Tukey (α = 0.05). Brushing with tapered-end bristles resulted in statistically significantly less abrasive dentine wear than round-end bristles regardless of the applied brushing force (1 N: 4.4 ± 1.5 vs. 7.7 ± 2.0 µm; 2 N: 7.7 ± 2.1 vs. 12.2 ± 2.7 µm; 3 N: 11.3 ± 2.6 vs. 19.4 ± 3.7 µm; 4 N: 11.2 ± 2.1 vs. 25.3 ± 4.8 µm). The interaction between bristle configuration and brushing force was statistically significantly (p < 0.001). Tapered-end toothbrushes might be a safer choice for patients, especially when showing signs of non-carious cervical lesion. However, other toothbrush properties should also be considered. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Margin Integrity of Conservative Composite Restorations after Resin Infiltration of Demineralized Enamel.
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Körner, Philipp, El Gedaily, Mohamed, Attin, Rengin, Wiedemeier, Daniel B., Attin, Thomas, and Tauböck, Tobias T.
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DENTAL fillings ,DENTAL adhesives ,INCISORS ,DENTAL enamel ,DENTAL caries - Abstract
Purpose: To investigate the influence of pretreating demineralized enamel with a caries infiltrant on the margin integrity of Class V composite restorations bonded with different adhesives. Materials and Methods: A total of 60 specimens from bovine incisors were demineralized (21 days, acid buffer, pH 4.95) to create artificial enamel lesions, and circular Class V cavities were prepared. Cavities of half of the specimens were treated with either an unfilled etch-and-rinse adhesive (Syntac Classic; Ivoclar Vivadent), a filled etch and-rinse adhesive (Optibond FL; Kerr), or a self-etch adhesive (iBond Self Etch; Heraeus Kulzer) (n = 10 per group). Demineralized enamel of the other half of the specimens was pretreated with a caries infiltrant (Icon; DMG) prior to adhesive application. All cavities were restored with a nanofilled composite material and thermocycled (5000 ×, 5°C-55°C). Margin integrity was evaluated using scanning electron microscopy, and the percentage of continuous margin was statistically analyzed (p < 0.05). Results: The significantly highest margin integrity was observed for Optibond FL, whether or not demineralized enamel was pretreated with the infiltrant. Pretreatment of demineralized enamel with the infiltrant resulted in a significant increase in margin integrity when the unfilled etch-and-rinse adhesive (Syntac Classic) or the self-etch adhesive (iBond Self Etch) was subsequently applied, but showed no significant improvement in combination with the filled etch-and-rinse adhesive (Optibond FL). Conclusion: Application of a caries infiltrant can improve margin integrity of composite fillings in demineralized enamel when used in combination with the examined self-etch and unfilled adhesives. [ABSTRACT FROM AUTHOR]
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- 2017
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19. Effect of toothbrush bristle stiffness and toothbrushing force on the abrasive dentine wear.
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Hamza, Blend, Tanner, Moritz, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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TOOTHBRUSHES ,STATISTICS ,TOOTH abrasion ,DENTIN ,CATTLE ,ANALYSIS of variance ,TOOTH care & hygiene ,ANIMAL experimentation ,DATA analysis - Abstract
Objective: To investigate the influence of toothbrush bristle stiffness and applied brushing force on the resulting abrasive dentine wear in vitro. Methods: One hundred sixty bovine dentine samples were randomly allocated in eight groups (n = 20). Groups one to four were brushed with a soft‐bristle toothbrush with soft bristles applying 1, 2, 3 and 4 N brushing force, respectively. Groups five to eight were brushed with a medium‐bristle toothbrush applying the same aforementioned brushing forces (120 strokes/min, abrasive slurry (RDA = 121), 25 min). Profiles were recorded before and after the brushing sequence, and the median and interquartile range of abrasive dentine wear were calculated and compared using two‐way ANOVA and pairwise tests corrected after Tukey (α = 0.05). Results: At 1, 2 and 3 N brushing force, the tested toothbrushes caused no significantly different abrasive dentine wear. At 4 N brushing force, the medium‐bristle toothbrush caused statistically significantly higher abrasive force than the soft‐bristle toothbrush. Using the medium‐bristle toothbrush, abrasive dentine wear statistically significantly increased with increasing brushing force from 1 to 3 N. However, increasing the brushing force to 4 N did not result in statistically significantly higher wear. Using the soft‐bristle toothbrush, abrasive dentine wear statistically significantly increased with increasing brushing force from 1 to 2 N. However, increasing the brushing force to 3 or 4 N did not result in statistically significantly higher wear. Conclusion: The soft‐bristle toothbrush tends to cause less abrasive wear with increasing brushing force than the medium‐bristle toothbrush. [ABSTRACT FROM AUTHOR]
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- 2021
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20. Effect of a sonic toothbrush on the abrasive dentine wear using toothpastes with different abrasivity values.
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Hamza, Blend, Uka, Entoni, Körner, Philipp, Attin, Thomas, and Wegehaupt, Florian Just
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TOOTHBRUSHES ,DENTIFRICES ,IN vitro studies ,STATISTICS ,DENTIN ,TOOTH abrasion ,CATTLE ,ANIMAL experimentation ,COMMERCIAL product evaluation ,DESCRIPTIVE statistics ,REPEATED measures design ,DATA analysis ,DATA analysis software - Abstract
Objective: This in vitro study aimed to investigate the effect of a sonic toothbrush on the resulting abrasive dentine wear using toothpastes with different abrasivities compared to the use of a manual toothbrush. Methods: Ninety‐six bovine dentine samples were divided into six groups and subjected to a brushing sequence (sonic: 20 min, 0.9 N, 10 strokes/min; manual: 20 min, 1.6 N, 60 strokes/min) as follows: group 1: Elmex Sensitive Plus (RDA = 28) + manual toothbrush; group 2: Elmex Sensitive + sonic toothbrush; group 3: Elmex Kariesschutz (RDA = 65) + manual toothbrush; group 4: Elmex Kariesschutz +sonic toothbrush; group 5: Colgate Total Original (RDA = 121) + manual toothbrush; and group 6: Colgate Total Original +sonic toothbrush. The abrasive dentine wear was measured profilometrically. Results: The median (IQR) abrasive dentine wear was as follows: Elmex Sensitive Plus (manual toothbrush: 2.7 µm (0.8), sonic toothbrush: 3.1 µm (1.9)); Elmex Kariesschutz (manual toothbrush: 4.9 µm (1.4), sonic toothbrush: 6.4 µm (2.1)); and Colgate Total Original (manual toothbrush: 5.2 µm (1.1), sonic toothbrush: 9.0 µm (3.1)). Differences in dentine wear between sonic and manual toothbrushes were statistically significant only in the groups brushed with Elmex Kariesschutz and Colgate Total Original (p ≤ 0.05). Conclusion: Brushing with a sonic toothbrush could result in a higher abrasive dentine wear compared to manual toothbrush when combined with toothpastes with high abrasivity values. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Effects of Additional Use of Bioactive Glasses or a Hydroxyapatite Toothpaste on Remineralization of Artificial Lesions in vitro.
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Körner, Philipp, Schleich, Jana A, Wiedemeier, Daniel B., Attin, Thomas, Wegehaupt, Florian J., Schleich, Jana A, Wiedemeier, Daniel B, and Wegehaupt, Florian J
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BIOACTIVE glasses , *TOOTH demineralization , *ARTIFICIAL saliva , *ORAL hygiene products , *TOOTHPASTE , *HYDROXYAPATITE , *KRUSKAL-Wallis Test , *DENTIFRICES , *IN vitro studies , *CATTLE , *REMINERALIZATION (Teeth) , *FLUORIDES , *ANIMAL experimentation , *MICRORADIOGRAPHY , *MINERALS , *DENTAL enamel , *CARIOSTATIC agents - Abstract
Objectives: This in vitro study aimed to evaluate and compare the effect of two different bioactive glasses, a hydroxyapatite-containing, fluoride-free toothpaste (HTP) and a fluoride toothpaste (FTP) on the remineralization behavior of initial caries lesions.Materials and Methods: A total of 100 bovine enamel samples were randomly allocated to five groups of 20 samples each: NC = negative control group (artificial saliva); HTP = HTP group (Karex); FTP = FTP group (Elmex caries protection, 1,400 ppm); FTP + BGnano = FTP followed by Actimins bioactive glass; FTP + BGamorph = FTP followed by Schott bioactive glass. Radiographic documentation (advanced transversal microradiography; aTMR) was applied before and after all samples were exposed to a demineralizing gel for 10 days. Over a period of 28 days, samples were covered twice a day (every 12 h) with a toothpaste slurry of the respective test group or with artificial saliva in NC for 60 s and brushed with 15 brushing strokes. Samples in FTP + BGnano and FTP + BGamorph were additionally treated with the respective bioactive glass slurry for 30 s after brushing with the FTP. In the meantime, all samples were stored in artificial saliva. After 28 days, the structure of all samples was assessed again using aTMR and compared to the values measured after demineralization. The statistical evaluation of the integrated mineral loss was performed using Kruskal-Wallis test followed by a post hoc Conover test.Results: The FTP revealed the significantly highest increase of mineral content while the HTP showed the significantly lowest remineralization. Compared to artificial saliva, the use of the HTP or the combined application of FTP followed by bioactive glasses (FTP + BGnano and FTP + BGamorph) showed no significant remineralization.Conclusion: Under remineralizing in vitro conditions, brushing with 1,400 ppm FTP induced significantly more remineralization compared to storage in artificial saliva. The additional administration of both bioactive glasses as well as the substitutional brushing with an HTP resulted in significantly less remineralization compared to brushing with 1,400 ppm FTP. [ABSTRACT FROM AUTHOR]- Published
- 2020
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22. Prevention of Enamel Softening by Rinsing with a Calcium Solution before Dental Erosion.
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Körner, Philipp, Wiedemeier, Daniel B., Attin, Thomas, and Wegehaupt, Florian Just
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TOOTH erosion , *SOFT drinks , *DENTAL enamel , *MAXILLA , *CALCIUM , *ORAL hygiene products , *BULIMIA , *ANIMAL experimentation , *CATTLE , *COMPARATIVE studies , *FLUORIDES , *RESEARCH methodology , *MEDICAL cooperation , *PHYSICS , *RESEARCH , *EVALUATION research - Abstract
Objectives: This in situ study aimed to evaluate whether rinsing with a calcium-containing solution prior to an erosive attack reduces the softening of enamel.Materials and Methods: A total of 240 bovine enamel samples with determined baseline surface microhardness (KHN) were allocated to 5 runs in which each of the 12 volunteers performed the following experiment: 4 enamel samples were inserted in a custom-made intraoral appliance and carried in the mouth (upper jaw) for 30 min before each volunteer either rinsed his mouth for 60 s with a fluoride- and stannous ion-containing dental erosion protection mouth rinse as positive control (run 1), milk (run 2), a solution prepared from a 500-mg calcium effervescent tablet dissolved in 100 mL (run 3) or 200 mL (run 4) water, or did not perform any rinsing with a test solution before the erosive attack (run 5, negative control). To simulate the erosive attack, volunteers rinsed their mouth with a commercial soft drink (Sprite Zero) for 60 s and afterwards with water to stop the erosive process. Finally, surface microhardness was measured again and hardness loss (ΔKHN) calculated. A mixed effect model was fitted to the data set to investigate whether the different runs showed differences with respect to ΔKHN.Results: No significant difference in softening of enamel (mean of ΔKHN; lower confidence level/upper confidence level) was observed between the negative control run 5 (50.7; 60.8/40.6), run 2 (50.7; 60.8/40.6), run 3 (38.7; 48.8/28.6) and run 4 (40.7; 50.8/30.6) (p > 0.05, respectively). Enamel softening in the positive control run 1 (25.4; 35.6/15.3) was significantly lower compared to the softening in run 5 (p < 0.001). No significant difference was observed between run 1 and run 3 (p = 0.09).Conclusion: Other than the fluoride- and stannous ion-containing dental erosion protection mouth rinse, none of the investigated calcium-containing solutions is able to significantly reduce erosion-induced softening of enamel. [ABSTRACT FROM AUTHOR]- Published
- 2020
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23. OralDisk: A Chair-Side Compatible Molecular Platform Using Whole Saliva for Monitoring Oral Health at the Dental Practice.
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Baumgartner, Desirée, Johannsen, Benita, Specht, Mara, Lüddecke, Jan, Rombach, Markus, Hin, Sebastian, Paust, Nils, von Stetten, Felix, Zengerle, Roland, Herz, Christopher, Peham, Johannes R., Paqué, Pune N., Attin, Thomas, Jenzer, Joël S., Körner, Philipp, Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Kaman, Wendy E., and Stubbs, Andrew
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PORPHYROMONAS gingivalis ,PRACTICE of dentistry ,STREPTOCOCCUS mutans ,ACTINOBACILLUS actinomycetemcomitans ,ORAL health ,SALIVA ,BACTERIAL DNA - Abstract
Periodontitis and dental caries are two major bacterially induced, non-communicable diseases that cause the deterioration of oral health, with implications in patients' general health. Early, precise diagnosis and personalized monitoring are essential for the efficient prevention and management of these diseases. Here, we present a disk-shaped microfluidic platform (OralDisk) compatible with chair-side use that enables analysis of non-invasively collected whole saliva samples and molecular-based detection of ten bacteria: seven periodontitis-associated (Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Fusobacterium nucleatum, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola) and three caries-associated (oral Lactobacilli, Streptococcus mutans, Streptococcus sobrinus). Each OralDisk test required 400 µL of homogenized whole saliva. The automated workflow included bacterial DNA extraction, purification and hydrolysis probe real-time PCR detection of the target pathogens. All reagents were pre-stored within the disk and sample-to-answer processing took < 3 h using a compact, customized processing device. A technical feasibility study (25 OralDisks) was conducted using samples from healthy, periodontitis and caries patients. The comparison of the OralDisk with a lab-based reference method revealed a ~90% agreement amongst targets detected as positive and negative. This shows the OralDisk's potential and suitability for inclusion in larger prospective implementation studies in dental care settings. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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24. Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring.
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Paqué, Pune N., Herz, Christopher, Wiedemeier, Daniel B., Mitsakakis, Konstantinos, Attin, Thomas, Bao, Kai, Belibasakis, Georgios N., Hays, John P., Jenzer, Joël S., Kaman, Wendy E., Karpíšek, Michal, Körner, Philipp, Peham, Johannes R., Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Bostanci, Nagihan, and Isola, Gaetano
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DENTAL caries ,SALIVARY proteins ,BACTERIAL proteins ,PROTEOLYTIC enzymes ,BIOMARKERS ,CHEMOKINES - Abstract
This study investigated the potential of salivary bacterial and protein markers for evaluating the disease status in healthy individuals or patients with gingivitis or caries. Saliva samples from caries- and gingivitis-free individuals (n = 18), patients with gingivitis (n = 17), or patients with deep caries lesions (n = 38) were collected and analyzed for 44 candidate biomarkers (cytokines, chemokines, growth factors, matrix metalloproteinases, a metallopeptidase inhibitor, proteolytic enzymes, and selected oral bacteria). The resulting data were subjected to principal component analysis and used as a training set for random forest (RF) modeling. This computational analysis revealed four biomarkers (IL-4, IL-13, IL-2-RA, and eotaxin/CCL11) to be of high importance for the correct depiction of caries in 37 of 38 patients. The RF model was then used to classify 10 subjects (five caries-/gingivitis-free and five with caries), who were followed over a period of six months. The results were compared to the clinical assessments of dental specialists, revealing a high correlation between the RF prediction and the clinical classification. Due to the superior sensitivity of the RF model, there was a divergence in the prediction of two caries and four caries-/gingivitis-free subjects. These findings suggest IL-4, IL-13, IL-2-RA, and eotaxin/CCL11 as potential salivary biomarkers for identifying noninvasive caries. Furthermore, we suggest a potential association between JAK/STAT signaling and dental caries onset and progression. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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25. Toothpastes with Enzymes Support Gum Health and Reduce Plaque Formation.
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Paqué, Pune N., Schmidlin, Patrick R., Wiedemeier, Daniel B., Wegehaupt, Florian J., Burrer, Phoebe D., Körner, Philipp, Deari, Shengjile, Sciotti, Michel-Angelo, and Attin, Thomas
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- 2021
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26. Microbial Analysis of Saliva to Identify Oral Diseases Using a Point-of-Care Compatible qPCR Assay.
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Paqué, Pune N., Herz, Christopher, Jenzer, Joël S., Wiedemeier, Daniel B., Attin, Thomas, Bostanci, Nagihan, Belibasakis, Georgios N., Bao, Kai, Körner, Philipp, Fritz, Tanja, Prinz, Julia, Schmidlin, Patrick R., Thurnheer, Thomas, Wegehaupt, Florian J., Mitsakakis, Konstantinos, and Peham, Johannes R.
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SALIVA analysis ,ORAL diseases ,ACTINOBACILLUS actinomycetemcomitans ,ORAL health ,SALIVA ,FIRE assay - Abstract
Oral health is maintained by a healthy microbiome, which can be monitored by state-of-the art diagnostics. Therefore, this study evaluated the presence and quantity of ten oral disease-associated taxa (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, C. rectus, P. intermedia, A. actinomycetemcomitans, S. mutans, S. sobrinus, oral associated Lactobacilli) in saliva and their clinical status association in 214 individuals. Upon clinical examination, study subjects were grouped into healthy, caries and periodontitis and their saliva was collected. A highly specific point-of-care compatible dual color qPCR assay was developed and used to study the above-mentioned bacteria of interest in the collected saliva. Assay performance was compared to a commercially available microbial reference test. Eight out of ten taxa that were investigated during this study were strong discriminators between the periodontitis and healthy groups: C. rectus, T. forsythia, P. gingivalis, S. mutans, F. nucleatum, T. denticola, P. intermedia and oral Lactobacilli (p < 0.05). Significant differentiation between the periodontitis and caries group microbiome was only shown for S. mutans (p < 0.05). A clear distinction between oral health and disease was enabled by the analysis of quantitative qPCR data of target taxa levels in saliva. [ABSTRACT FROM AUTHOR]
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- 2020
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27. Disaggregation of meteorological input data from daily to hourly resolution.
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Körner, Philipp
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STANDARD deviations , *RUNOFF models , *WIND speed , *TREND analysis - Abstract
Meteorological input data in hourly resolution is a prerequisite for numerous hydrological applications, including hydrological modelling, precipitation runoff modelling and flood modelling in general. Historical meteorological time series are mainly available in daily resolution. Furthermore, it is recommended to use daily or even longer temporal steps of raw projected data, which also illustrates the need of hourly projected data for climate impact assessment. In order to be able to model these periods it is necessary to disaggregate daily values to hourly values. We present an approach, which synchronously performs an hourly disaggregation for different meteorological measurants based on measured data. The model is applied for periods or stations where no hourly data is available. It is trained using gradient boosting and depends on the daily averages of meteorological parameters such as temperature, humidity, radiation, wind speed and precipitation. The model was tested for about 200 climate stations in Germany. The cross validation shows very high quality measures such as root mean square error of temperature to be less than 1.2°C on average. In addition, the spatial consistency was ensured, hence the correlation of the measured hourly values of two stations is equal to the correlation of the disaggregated hourly values of the stations. This statement is valid for stations close to each other as well as for distant stations. A high correlation can be observed even for hourly precipitation values. [ABSTRACT FROM AUTHOR]
- Published
- 2019
28. Fog deposition as an important contribution to the water budget.
- Author
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Bernhofer, Christian, Körner, Philipp, and Kronenberg, Rico
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FOG , *LEAF area index , *WATERSHEDS , *MOUNTAINS , *GRID cells - Abstract
In some catchments, especially in low mountain ranges, fog deposition can make a considerable contribution to the water budget. Yet, fog deposition is usually not measured, hence gaps between observed and expected discharge in the water balance of these catchments arise. These gaps are ignored, or either corrected by calibration, like by decreasing the evaporation or corrected with general approaches like an additional fog water input depending on the elevation.We present an approach, which is capable to estimate physically justified the fog deposition in dependence on the vegetation. The method requires only limited data and meteorological standard measurements are used. The calculations are done on a spatial basis and have been performed for Germany. First, liquid water content (lwc) at ground level is derived and interpolated to grid cells. The temporal resolution of the lwc-product is 1 hour and the spatial resolution 1 kilometre per grid cell. Second, deposition velocities based on measurements are determined for the study area. Last, the fog deposition can be estimated from the lwc-product, the deposition velocity and the actual vegetation properties (i.e. height of vegetation, Leaf Area Index).Depending on the catchment area, the additional precipitation input due to fog precipitation contributes up to 50 % to the annual precipitation. This is a considerable portion of the overall input and needs to be discussed, in order to avoid misleading effects of water budget model calibration in mountain ranges. [ABSTRACT FROM AUTHOR]
- Published
- 2019
29. Patientenberichtete Symptome im Strahlentherapieverlauf : Klinisch relevante Symptombelastungen bei Patienten mit palliativer und kurativer Therapieintention.
- Author
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Körner, Philipp, Ehrmann, Katja, Hartmannsgruber, Johann, Metz, Michaela, Steigerwald, Sabrina, Flentje, Michael, and van Oorschot, Birgitt
- Subjects
QUALITY of life ,MENTAL health ,TUMORS & psychology ,BONE tumors ,FATIGUE (Physiology) ,HEALTH status indicators ,LONGITUDINAL method ,PALLIATIVE treatment ,RADIATION doses ,SELF-evaluation ,RADIATION injuries ,TUMORS ,PSYCHOLOGY ,DIAGNOSIS - Abstract
Background: The benefits of patient-reported symptom assessment combined with integrated palliative care are well documented. This study assessed the symptom burden of palliative and curative-intent radiation oncology patients.Patients and Methods: Prior to first consultation and at the end of RT, all adult cancer patients planned to receive fractionated percutaneous radiotherapy (RT) were asked to answer the Edmonton Symptom Assessment Scale (ESAS; nine symptoms from 0 = no symptoms to 10 = worst possible symptoms). Mean values were used for curative vs. palliative and pre-post comparisons, and the clinical relevance was evaluated (symptom values ≥ 4).Results: Of 163 participating patients, 151 patients (90.9%) completed both surveys (116 curative and 35 palliative patients). Before beginning RT, 88.6% of palliative and 72.3% of curative patients showed at least one clinically relevant symptom. Curative patients most frequently named decreased general wellbeing (38.6%), followed by tiredness (35.0%), anxiety (32.4%), depression (30.0%), pain (26.3%), lack of appetite (23.5%), dyspnea (17.8%), drowsiness (8.0%) and nausea (6.1%). Palliative patients most frequently named decreased general wellbeing (62.8%), followed by pain (62.8%), tiredness (60.0%), lack of appetite (40.0%), anxiety (38.0%), depression (33.3%), dyspnea (28.5%), drowsiness (25.7%) and nausea (14.2%). At the end of RT, the proportion of curative and palliative patients with a clinically relevant symptom had increased significantly to 79.8 and 91.4%, respectively; whereas the proportion of patients reporting clinically relevant pain had decreased significantly (42.8 vs. 62.8%, respectively). Palliative patients had significantly increased tiredness. Curative patients reported significant increases in pain, tiredness, nausea, drowsiness, lack of appetite and restrictions in general wellbeing.Conclusion: Assessment of patient-reported symptoms was successfully realized in radiation oncology routine. Overall, both groups showed a high symptom burden. The results prove the need of systematic symptom assessment and programs for early integrated supportive and palliative care in radiation oncology. [ABSTRACT FROM AUTHOR]- Published
- 2017
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30. Effect of Caries Infiltrant on Margin Integrity of Composite Fillings Placed Adjacent to Demineralised Primary Enamel.
- Author
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Attin R, Rüedi N, Tauböck TT, Körner P, Wiedemeier D, and Attin T
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- Composite Resins, Dental Caries Susceptibility, Dental Enamel, Dental Marginal Adaptation, Dental Restoration, Permanent, Dentin-Bonding Agents, Humans, Materials Testing, Dental Bonding, Dental Caries therapy
- Abstract
Purpose: To investigate the influence of pretreating demineralised enamel with an infiltrant on the margin integrity of Class V like composite restorations on primary teeth bonded with different adhesives., Materials and Methods: Forty specimens from primary molars were demineralised and circular class-V-like cavities were prepared. The cavities were treated with a universal adhesive (Scotchbond Universal Adhesive, 3M Oral Care), applied either in self-etch (SE) or etch-and-rinse mode (ER) mode. In groups SE-I and ER-I, the demineralised margins were pretreated with a caries infiltrant (Icon, DMG) prior to adhesive application. The cavities were restored with a nanofilled composite material and thermocycled. Marginal integrity was evaluated using SEM, and the percentage of continuous margin was statistically analysed., Results: Specimens treated with the caries infiltrant followed by the adhesive showed similar marginal continuity as the adhesive alone., Conclusions: Pretreatment of demineralised primary enamel with a caries infiltrant before applying a universal adhesive does not influence the marginal integrity of composite fillings.
- Published
- 2021
- Full Text
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31. Enamel Softening Can Be Reduced by Rinsing with a Fluoride Mouthwash Before Dental Erosion but Not with a Calcium Solution.
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Körner P, Nguyen TP, Hamza B, Attin T, and Wegehaupt FJ
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- Animals, Calcium, Cattle, Dental Enamel, Humans, Mouthwashes, Sodium Fluoride, Fluorides, Tooth Erosion prevention & control
- Abstract
Purpose: This in-situ-study investigated if rinsing the oral cavity with a calcium containing solution or a fluoride containing mouthwash immediately before an erosive attack leads to reduced enamel softening., Materials and Methods: Bovine enamel samples (n = 240) with measured baseline surface microhardness (KHN) were assigned to five series (S1-5). Twelve participants carried out each series as follows: Four enamel samples of the associated test series were placed in an intraoral appliance and carried in each participants' mouth. After 30 min, the participants either rinsed the oral cavity for 60 s with 30 ml of a solution prepared from a 1,000 mg calcium effervescent tablet dissolved in 100 ml water (S2), an 800 mg calcium containing mineral supplement powder (5 g) dissolved in 200 ml water (S3), a fluoride (500 ppm) mouthwash (S4), a fluoride (500 ppm) and stannous chloride (800 ppm) containing mouthwash (S5), or did not rinse with any test solution before the erosive attack (S1, negative control). The participants subsequently rinsed the oral cavity with 100 ml of a soft drink (Sprite Zero) for 60 s to simulate the erosive attack and immediately afterwards with water to stop the erosive process. As final step, surface microhardness was measured a second time and hardness loss (∆KHN) calculated. Differences of ∆KHN between the series were investigated by fitting a mixed effect model to the data set., Results: The highest loss of microhardness and thus softening of enamel (mean of ∆KHN; lower/upper confidence level) was observed in the negative control (S1: 60.2; 67.6/52.8). While no statistically significant difference (P > 0.05) compared to S1 could be found in S2 (50.0; 57.4/42.5) and S3 (54.6; 62.1/47.2), statistically significantly less softening of enamel (P < 0.001) was discovered in S5 (33.8; 41.2/26.4) and S4 (41.8.2; 49.3/34.4). S5 showed the overall lowest values for ∆KHN and thus best protection from enamel softening., Conclusion: Rinsing with a fluoride mouthwash or a fluoride and stannous chloride containing mouthwash immediately before an erosive attack reduces the softening of enamel. None of the investigated calcium-containing solutions was able to reduce erosion induced softening of enamel.
- Published
- 2021
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32. Green Tea Extract Reduces the Erosive Dentine Wear Caused by Energy Drinks In Vitro.
- Author
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Hamza B, Rojas SAP, Körner P, Attin T, and Wegehaupt FJ
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- Animals, Cattle, Dentin, Tea, Energy Drinks adverse effects, Plant Extracts pharmacology, Tooth Erosion prevention & control
- Abstract
Purpose: To investigate the effect of energy drinks supplementation with green tea extract on the erosive dentine wear., Materials and Methods: Six groups of bovine dentine samples (n = 15) were subjected to four cycles erosive attacks (10 min, 25 °C) and remineralisation (artificial saliva, 60 min, 37°C) using the following formulas: tap water; green tea extract; Red Bull; Red Bull supplemented with green tea extract; Red Bull Light; Red Bull Light supplemented with green tea extract. The erosive dentine wear - ie, the irreversible dentine loss - was measured using a stylus profilometer (µm, accuracy = 40 nm)., Results: Median and interquartile range (IQR) of erosive dentine wear for the tested energy drinks before and after the supplementation with green tea extract were calculated as follows: Red Bull (before: 3.3 µm (1.0)); after: 1.2 µm (0.6)); Red Bull Light (before: 3.3 µm (0.9)); after: 2.0 µm (0.4)). The difference between the groups before and after the supplementation was statistically significant (P ˂0.05). The erosive dentine wear for the tap water group was calculated at 0.4 µm (0.6) and for the green tea extract group at -1.0 µm (1.3)., Conclusions: Supplementation of energy drinks with green tea extract could reduce the erosive dentine wear caused by energy drink in vitro.
- Published
- 2021
- Full Text
- View/download PDF
33. [Assessment of dentists' opinions on the cause of failure of adhesive composite restorations].
- Author
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Körner P, Wegehaupt FJ, and Attin T
- Subjects
- Composite Resins, Dental Cements, Dental Restoration Failure, Dentists, Humans, Dental Restoration, Permanent, Practice Patterns, Dentists'
- Abstract
Aim of this study was to get an overview of what dentists estimate to be the reason for failure of adhesive composite restorations and to gain knowledge about potential future foci for targeted further education. Therefore, a survey about the fabrication of composite restorations was conducted in the course of seven dental conferences with the main topic tooth-prevention. A total of 577 dentists participated in the survey. The most often called estimated factor for failure of composite restorations was the "dentist" (70.7%), followed by "indication" (32.2%), "material" (8.5%) and "patient" (8.1%). Participants estimated insufficient drying and fluid management (67.9%), incorrect application of the adhesive system (41.8%), insufficient lightpolymerisation (31.2%) and errors in incremental technique (27.6%) to be the main mistakes. The participating dentists claimed to attach great importance to careful drying and fluid management (60.8%), thorough adhesive application (37.3%), adequate incremental technique (32.6%) and sufficient lightpolymerisation (28.8%) while placing their own restorations. According to the survey participants, the treating dentist has the greatest influence on the quality and longevity of composite restorations. Drying and fluid management was the most often called estimated reason for failure but at the same time the step which is given the greatest caution.
- Published
- 2021
- Full Text
- View/download PDF
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