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Your search keyword '"Jouneau, Stéphane"' showing total 326 results
Start Over Author "Jouneau, Stéphane" Publication Type Academic Journals
326 results on '"Jouneau, Stéphane"'

1. SPLF/SMFU/SRLF/SFAR/SFCTCV Guidelines for the management of patients with primary spontaneous pneumothorax

Author

Jouneau, Stéphane, Ricard, Jean-Damien, Seguin-Givelet, Agathe, Bigé, Naïke, Contou, Damien, Desmettre, Thibaut, Hugenschmitt, Delphine, Kepka, Sabrina, Le Gloan, Karinne, Maitre, Bernard, Mangiapan, Gilles, Marchand-Adam, Sylvain, Mariolo, Alessio, Marx, Tania, Messika, Jonathan, Noël-Savina, Elise, Oberlin, Mathieu, Palmier, Ludovic, Perruez, Morgan, Pichereau, Claire, Roche, Nicolas, Garnier, Marc, and Martinez, Mikaël

Published
2023
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6. SPLF/SMFU/SRLF/SFAR/SFCTCV Guidelines for the management of patients with primary spontaneous pneumothorax: Endorsed by the French Speaking Society of Respiratory Diseases (SPLF), the French Society of Emergency Medicine (SFMU), the French Intensive Care Society (SRLF), the French Society of Anesthesia & Intensive Care Medicine (SFAR) and the French Society of Thoracic and Cardiovascular Surgery (SFCTCV)

Author

Jouneau, Stéphane, Ricard, Jean-Damien, Seguin-Givelet, Agathe, Bigé, Naïke, Contou, Damien, Desmettre, Thibaut, Hugenschmitt, Delphine, Kepka, Sabrina, Gloan, Karinne Le, Maitre, Bernard, Mangiapan, Gilles, Marchand-Adam, Sylvain, Mariolo, Alessio, Marx, Tania, Messika, Jonathan, Noël-Savina, Elise, Oberlin, Mathieu, Palmier, Ludovic, Perruez, Morgan, Pichereau, Claire, Roche, Nicolas, Garnier, Marc, and Martinez, Mikaël

Published
2023
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7. French practical guidelines for the diagnosis and management of idiopathic pulmonary fibrosis – 2021 update. Full-length version

Author

Cottin, Vincent, Bonniaud, Philippe, Cadranel, Jacques, Crestani, Bruno, Jouneau, Stéphane, Marchand-Adam, Sylvain, Nunes, Hilario, Wémeau-Stervinou, Lidwine, Bergot, Emmanuel, Blanchard, Elodie, Borie, Raphaël, Bourdin, Arnaud, Chenivesse, Cécile, Clément, Annick, Gomez, Emmanuel, Gondouin, Anne, Hirschi, Sandrine, Lebargy, François, Marquette, Charles-Hugo, Montani, David, Prévot, Grégoire, Quetant, Sébastien, Reynaud-Gaubert, Martine, Salaun, Mathieu, Sanchez, Olivier, Trumbic, Bruno, Berkani, Karim, Brillet, Pierre-Yves, Campana, Marion, Chalabreysse, Lara, Chatté, Gérard, Debieuvre, Didier, Ferretti, Gilbert, Fourrier, Jean-Michel, Just, Nicolas, Kambouchner, Marianne, Legrand, Bertrand, Le Guillou, Frédéric, Lhuillier, Jean-Pierre, Mehdaoui, Anas, Naccache, Jean-Marc, Paganon, Catherine, Rémy-Jardin, Martine, Si-Mohamed, Salim, and Terrioux, Philippe

Published
2023
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11. Treatment of Idiopathic Pulmonary Fibrosis with Capsule or Tablet Formulations of Pirfenidone in the Real-Life French RaDiCo-ILD Cohort

Author

Cottin, Vincent, Guéguen, Sonia, Nunes, Hilario, Jouneau, Stéphane, Crestani, Bruno, Bonniaud, Philippe, Wemeau, Lidwine, Israël-Biet, Dominique, Reynaud-Gaubert, Martine, Gondouin, Anne, Cadranel, Jacques, Marchand-Adam, Sylvain, Chevereau, Marie, Dufaure-Garé, Isabelle, Amselem, Serge, and Clément, Annick

Published
2022
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12. Tracheobronchopathia osteochondroplastica: clinical, bronchoscopic, and comorbid features in a case series

Author

Dumazet, Antoine, Launois, Claire, Lebargy, Francois, Kessler, Romain, Vallerand, Hervé, Schmitt, Pierre, Hermant, Christophe, Dury, Sandra, Dewolf, Maxime, Dutilh, Julien, Abouda, Maher, Ferreira, Marion, Atallah, Ihab, Lachkar, Samy, Charriot, Jérémy, Jouneau, Stéphane, Uzunhan, Yurdagul, Chouabe, Stéphane, Coiffard, Benjamin, Dutau, Hervé, Hagenburg, Jean, Briault, Amandine, Dormoy, Valérian, Lirsac, Marion, Vergnon, Jean-Michel, Deslee, Gaetan, and Perotin, Jeanne-Marie

Published
2022
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13. Chronic use of inhaled corticosteroids in patients admitted for respiratory virus infections: a 6-year prospective multicenter study

Author

Luque-Paz, David, Tattevin, Pierre, Loubet, Paul, Bénézit, François, Thibault, Vincent, Lainé, Fabrice, Vanhems, Philippe, Amour, Selilah, Lina, Bruno, Duval, Xavier, L’Honneur, Anne-Sophie, Fidouh, Nadhira, Vallejo, Christine, Alain, Sophie, Galtier, Florence, Foulongne, Vincent, Lagathu, Gisèle, Lenzi, Nezha, Lesieur, Zineb, Launay, Odile, and Jouneau, Stéphane

Published
2022
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15. Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Naccache, Jean-Marc, Jouneau, Stéphane, Didier, Morgane, Borie, Raphaël, Cachanado, Marine, Bourdin, Arnaud, Reynaud-Gaubert, Martine, Bonniaud, Philippe, Israël-Biet, Dominique, Prévot, Grégoire, Hirschi, Sandrine, Lebargy, François, Marchand-Adam, Sylvain, Bautin, Nathalie, Traclet, Julie, Gomez, Emmanuel, Leroy, Sylvie, Gagnadoux, Frédéric, Rivière, Frédéric, Bergot, Emmanuel, Gondouin, Anne, Blanchard, Elodie, Parrot, Antoine, Blanc, François-Xavier, Chabrol, Alexandre, Dominique, Stéphane, Gibelin, Aude, Tazi, Abdellatif, Berard, Laurence, Brillet, Pierre Yves, Debray, Marie-Pierre, Rousseau, Alexandra, Kerjouan, Mallorie, Freynet, Olivia, Dombret, Marie-Christine, Gamez, Anne-Sophie, Nieves, Ana, Beltramo, Guillaume, Pastré, Jean, Le Borgne-Krams, Aurélie, Dégot, Tristan, Launois, Claire, Plantier, Laurent, Wémeau-Stervinou, Lidwine, Cadranel, Jacques, Chenivesse, Cécile, Valeyre, Dominique, Crestani, Bruno, Cottin, Vincent, Simon, Tabassome, and Nunes, Hilario

Published
2022
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16. Prognostic value and predictors of the alteration of the diffusing capacity of the lungs for carbon monoxide in systemic lupus erythematosus.

Author

Tallec, Erwan Le, Bourg, Corentin, Bouzillé, Guillaume, Belhomme, Nicolas, Pabic, Estelle Le, Guillot, Stéphanie, Droitcourt, Catherine, Perlat, Antoinette, Jouneau, Stéphane, Donal, Erwan, and Lescoat, Alain

Subjects
LUNG physiology, PULMONARY function tests, PULMONARY gas exchange, QUALITATIVE research, PREDICTION models, MICROCIRCULATION, SMOKING, LOGISTIC regression analysis, SYSTEMIC lupus erythematosus, SEVERITY of illness index, RETROSPECTIVE studies, INTERSTITIAL lung diseases, QUANTITATIVE research, MULTIVARIATE analysis, DESCRIPTIVE statistics, CONNECTIVE tissue diseases, ODDS ratio, KAPLAN-Meier estimator, LOG-rank test, CARBON monoxide, MEDICAL records, ACQUISITION of data, STATISTICS, LUNG volume measurements, CONFIDENCE intervals, DATA analysis software, DIFFUSION
Abstract

Objectives SLE is a systemic autoimmune disease characterized by heterogeneous manifestations and severity, with frequent lung involvement. Among pulmonary function tests, the measure of the diffusing capacity of the lungs for carbon monoxide (DLCO) is a noninvasive and sensitive tool assessing pulmonary microcirculation. Asymptomatic and isolated DLCO alteration has frequently been reported in SLE, but its clinical relevance has not been established. Methods This retrospective study focused on 232 SLE patients fulfilling the 2019 EULAR/ACR classification criteria for SLE. Data were collected from the patient's medical record, including demographic, clinical and immunological characteristics, while DLCO was measured when performing pulmonary function tests as part of routine patient follow-up. Results At the end of follow-up, DLCO alteration (<70% of predicted value) was measured at least once in 154 patients (66.4%), and was associated with a history of smoking as well as interstitial lung disease, but was also associated with renal and neurological involvement. History of smoking, detection of anti-nucleosome autoantibodies and clinical lymphadenopathy at diagnosis were independent predictors of DLCO alteration, while early cutaneous involvement with photosensitivity was a protective factor. DLCO alteration, at baseline or any time during follow-up, was predictive of admission in intensive care unit and/or of all-cause death, both mainly due to severe disease flares and premature cardiovascular complications. Conclusion This study suggests a link between DLCO alteration and disease damage, potentially related to SLE vasculopathy, and a prognostic value of DLCO on death or intensive care unit admission in SLE. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Low income and outcome in idiopathic pulmonary fibrosis: An association to uncover

Author

Bouvry, Diane, Brillet, Pierre Yves, Camus, Philippe, Chabrol, Juliette, Cordier, Jean François, Cracco, Christophe, Delaval, Philippe, Didier, Morgane, Duchemann, Boris, Feuillet, Sevrine, Freynet, Olivia, Gagnadoux, Frédéric, Germaud, Patrick, Gindre, Louise, Guetta, André, Haussman, Patrick, Jouneau, Stephane, Kambouchner, Marianne, Khouatra, Chahera, Lacronique, Jacques, Molard, Anita, Picard, Clément, Planes, Carole, Rosental, Paul Andrés, Sanchez, Olivier, Similowski, Thomas, Thiberville, Luc, Uzuhnan, Yurdagül, Sesé, Lucile, Caliez, Julien, Annesi-Maesano, Isabella, Cottin, Vincent, Pesce, Giancarlo, Carton, Zohra, Israel-Biet, Dominique, Crestani, Bruno, Dudoret, Stéphanie Guillot, Cadranel, Jacques, Wallaert, Benoit, Tazi, Abdellatif, Maître, Bernard, Prévot, Grégoire, Marchand-Adam, Sylvain, Hirschi, Sandrine, Dury, Sandra, Giraud, Violaine, Gondouin, Anne, Bonniaud, Philippe, Traclet, Julie, Juvin, Karine, Borie, Raphael, Bernaudin, Jean François, Valeyre, Dominique, Cavalin, Catherine, and Nunes, Hilario

Published
2021
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19. Prospective Multicenter Validation of the Detection of ALK Rearrangements of Circulating Tumor Cells for Noninvasive Longitudinal Management of Patients With Advanced NSCLC

Author

Israel-Biet, Dominique, Pison, Christophe, Moro-Sibilot, Denis, Lantuejoul, Sylvie, Stephanov, Olivier, Juliette, Meyzenc, Mendozat, Christophe, Zaidi, Manel, Coulouvrat, Sandra, Col, Edwige, Chanez, Pascal, Greillier, Laurent, Tomasini, Pascale, Barlesi, Fabrice, Mascaux, Céline, Jourdan, Sandrine, Roger, Aurélie, Biemar, Julie, Randriamampionona, Rondro, Chabot, François, Tiotiu, Angélica, Clement-Duchene, Christelle, Vignaud, Jean-Michel, Lacomme, Stéphanie, Lomazzi, Sandra, Laurent, Carine, Bulsei, Xavier, Bischoff, Laura, Rakotonirina, Raymond, Layouni, Mehdi, Deslee, Gaëtan, Mal, Hervé, Kessler, Romain, Vergnon, Jean-Michel, Pelissier, Isabelle, Cuvelier, Antoine, Bourdin, Arnaud, Jounieaux, Vincent, Roche, Nicolas, Jouneau, Stéphane, Bonniaud, Philippe, Scherpereel, Arnaud, Mornex, Jean François, Steenhouwer, François, Leroy, Sylvie, Marquette, Charles Hugo, Benzaquen, Jonathan, Mazzette, Andrea, Padovani, Bernard, Hofman, Paul, Ilié, Marius, Hofman, Véronique, Fayada, Julien, Long-Mira, Elodie, Lassalle, Sandra, Pradelli, Johanna, Martinez, Estelle, Habault, Marine, Bonnard, Mélanie, Moutarde, Julie, Yatimi, Rachida, Labsi, Hakima, Gazoppi, Loïc, Lpce, Tumorothèque, Griffonnet, Jennifer, Fontaine, Maureen, Guillemart, Ariane, Butori, Catherine, Selva, Eric, Poudenx, Michel, Otto, Josiane, Hebert, Christophe, Botchiellini, Delphine, Boudouf, Soukaina, Menier, Margaux, Occeli, Estelle, Bellentani, Sophie, Pion, Carine, Fournier, Elodie, Thariat, Juliette, Gervais, Radj, Hamond, Karim, Marchand-Adam, Sylvain, Plantier, Laurent, Fajolle, Gaelle, Rayez, Mélanie, Cadranel, Jacques, Fallet, Vincent, Wislez, Marie, Antoine, Martine, Cote, Jean-François, Chaabane, Nouha, Ruppert, Anne Marie, Bertrand, Eliane, Rodenas, Anita, Pontdeme, Gwenaëlle, Mathiot, Nathalie, Ribert, Tamazouzt, Mazières, Julien, Guibert, Nicolas, Rouviere, Damien, Bousquet, Emilie, Bigay-Game, Laurence, Hermant, Christophe, Plat, Gavin, Rouquette, Isabelle, Evrard, Solène, Gouin, Sandrine, Clermont, Estelle Taranchon, Dormoy, Inge, Coulomb, Christelle, Pradine, Anne, Lambert, Véronique, Laborde, Lilian, Castelnau, Olivier, Chamorey, Emmanuel, Heeke, Simon, Thamphya, Brice, Boutros, Jacques, Clément-Duchêne, Christelle, and Marquette, Charles-Hugo

Published
2021
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23. Circulating tumour cells as a potential biomarker for lung cancer screening: a prospective cohort study

Author

MARQUETTE, Charles-Hugo, BOUTROS, Jacques, Benzaquen, Jonathan, FERREIRA, Marion, PASTRE, Jean, Pison, Christophe, PADOVANI, Bernard, BETTAYEB, Faiza, FALLET, Vincent, GUIBERT, Nicolas, BASILLE, Damien, ILIE, Marius, HOFMAN, Véronique, HOFMAN, Paul, ISRAEL-BIET, Dominique, CHABOT, François, GUILLAUMOT, Anne, DESLEE, Gaetan, PEROTIN, Jeanne-Marie, DURY, Sandra, MAL, Hervé, MARCEAU, Armelle, Kessler, Romain, Vergnon, Jean-Michel, Pelissier, Carole, Di Palma, Fabrice, Cuvelier, Antoine, PATOUT, Maxime, Bourdin, Arnaud, GAMEZ, Anne Sophie, ANDREJAK, Claire, POULET, Claire, FRANCOIS, Géraldine, Jounieaux, Vincent, Roche, Nicolas, Jouneau, Stéphane, Brinchault, Graziella, Bonniaud, Philippe, ZOUAK, Ayoub, Scherpereel, Arnaud, BALDACCI, Simon, CORTOT, Alexis, Mornex, Jean François, Steenhouwer, François, LEROY, Sylvie, BERTHET, Jean-Philippe, FONTAS, Eric, BULSEI, Julie, CRUZEL, Coralie, Pradelli, Johanna, Fontaine, Maureen, MANIEL, Charlotte, Griffonnet, Jennifer, BUTORI, Catherine, SELVA, Eric, POUDENX, Michel, AguilanIu, Bernard, Ferretti, Gilbert, Arbib, François, Briault, Amandine, Toffart, Anne-Claire, Dahalani, Raissa, Destors, Marie, Chanez, Pascal, GREILLIER, Laurent, ASTOUL, Philippe, BARLESI, Fabrice, GAUBERT, Jean-Yves, Mazières, Julien, Marchand-Adam, Sylvain, Cadranel, Jacques, CHAABANE, Nouha, IZADIFAR, Armine, ROSENCHER, Lise, RUPPERT, Anne-Marie, VIEIRA, Thibault, MATHIOT, Nathalie, Marquette, Charles-Hugo, Boutros, Jacques, Ferreira, Marion, Pastre, Jean, Padovani, Bernard, Bettayeb, Faiza, Fallet, Vincent, Guibert, Nicolas, Basille, Damien, Ilie, Marius, Hofman, Véronique, and Hofman, Paul

Published
2020
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26. Biomarkers of extracellular matrix turnover in patients with idiopathic pulmonary fibrosis given nintedanib (INMARK study): a randomised, placebo-controlled study

Author

Corte, Tamera, Glaspole, Ian, Holmes, Mark, Troy, Lauren, Veitch, Elizabeth, Bondue, Benjamin, Dahlqvist, Caroline, Louis, Renaud, Van Meerbeeck, Jan, Wuyts, Wim, Bittenglova, Radka, Kolek, Vitezslav, Pauk, Norbert, Reiterer, Pavel, Sterclova, Martina, Kilpeläinen, Maritta, Mäkitaro, Riitta, Myllärniemi, Marjukka, Purokivi, Minna, Rantala, Terhi, Cottin, Vincent, Couturaud, Francis, Israel-Biet, Dominique, Jouneau, Stéphane, Kessler, Romain, Lebargy, François, Marchand-Adam, Sylvain, Bollmann, Tom, Günther, Andreas, Hammerl, Peter, Kirschner, Joachim, Kirsten, Anne-Marie, Kreuter, Michael, Neurohr, Claus, Prasse, Antje, Schönfeld, Nicolas, Wiewrodt, Rainer, Attila, Somfay, Balazs, Medgyasszay, Csanky, Eszter, Losonczy, György, Hayashi, Hiroki, Homma, Sakae, Inoue, Yoshikazu, Izumi, Shinyu, Kitamura, Hideya, Nishioka, Yasuhiko, Nishiyama, Osamu, Ogura, Takashi, Okamoto, Masaki, Saito, Takefumi, Taniguchi, Hiroyuki, Zaizen, Yoshiaki, Filipowska, Marzena, Jarzemska, Agnieszka, Pierzchala, Wladyslaw, Piotrowski, Wojciech, Sladek, Krzysztof, Trawinska, Ewa, Kim, Young Whan, Park, Jong Sun, Song, Jin Woo, Aburto, Myriam, Castillo Villegas, Diego, Echave-Sustaeta, José María, Garcia Fadul, Christian, Herrera, Susana, Moises, Jorge, Molina-Molina, María, Moreno, Amalia, Nieto, Asunción, Rodríguez Nieto, María Jesús, Rodriguez-Portal, José Antonio, Safont, Belen, Sellares, Jacobo, Valenzuela, Claudia, Adamali, Huzaifa, Chaudhuri, Nazia, Gibbons, Michael, Hoyles, Rachel, Maher, Toby, Parfrey, Helen, Averill, Francis, Chambers, Steven, Ettinger, Neil, Giessel, Glenn, Jones, Lisa M, Kaye, Mitchell G, Oelberg, David, Westerman, Jan H, Zoz, Donald, III, Maher, Toby M, Stowasser, Susanne, White, Eric S, Noth, Imre, Selman, Moisés, Rohr, Klaus B, Michael, Andreas, Ittrich, Carina, Diefenbach, Claudia, and Jenkins, R Gisli

Published
2019
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30. Early detection of chronic obstructive pulmonary disease in primary care: a randomised controlled trial.

Author

Chapron, Anthony, Andres, Emilie, Fiquet, Laure, Pelé, Fabienne, Allory, Emmanuel, Le Pabic, Estelle, Veislinger, Aurélie, Le Guillou, Lisa, Guillot, Stéphanie, Laviolle, Bruno, and Jouneau, Stéphane

Subjects
CHRONIC obstructive pulmonary disease, RANDOMIZED controlled trials, OBSTRUCTIVE lung diseases, VITAL capacity (Respiration), FORCED expiratory volume
Abstract

Background: Worldwide, chronic obstructive pulmonary disease (COPD) remains largely underdiagnosed. Aim: To assess whether the use of Global Initiative for Chronic Obstructive Lung Disease (GOLD) questions and COPD coordination, either alone or combined, would detect new COPD cases in primary care. Design and setting: GPs in Brittany, France, systematically enrolled patients aged 40–80 years over a 4-month period in this French multicentre cluster randomised controlled study. Method: GPs were randomly allocated to one of four groups: control (standard of care), GOLD questions (adapted from symptoms and risk factors identified by GOLD), COPD coordination, and GOLD questions with COPD coordination. New cases of COPD were those confirmed by spirometry: post-bronchodilator forced expiratory volume in 1 second over forced vital capacity of <0.7. Results: In total, 11 430 consultations were conducted by 47 GPs, who enrolled 3162 patients who did not have prior diagnosed asthma or COPD. Among these, 802 (25%) were enrolled in the control, 820 (26%) in the GOLD questions, 802 (25%) in the COPD coordination, and 738 (23%) in the GOLD questions with COPD coordination groups. In the control group, COPD was not evoked, and no spirometry was prescribed. All new cases of COPD diagnosed (n = 24, 0.8%) were in the intervention groups, representing 6.8% of patients who performed spirometry. Statistically significantly more new cases of COPD were detected with COPD coordination (P = 0.01). Conclusion: Interventions that can be easily implemented, such as the GOLD questions and COPD coordination, can identify new cases of COPD. Studies are needed to identify the most appropriate case-finding strategies for GPs to detect COPD in primary care for each country. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Determinants of survival after lung transplantation in telomerase-related gene mutation carriers: A retrospective cohort

Author

Phillips-Houlbracq, Mathilde, Mal, Hervé, Cottin, Vincent, Gauvain, Clément, Beier, Fabian, Sicre de Fontbrune, Flore, Sidali, Sabrina, Mornex, Jean François, Hirschi, Sandrine, Roux, Antoine, Weisenburger, Gaelle, Roussel, Arnaud, Wémeau-Stervinou, Lidwine, Le Pavec, Jérôme, Pison, Christophe, Marchand Adam, Sylvain, Froidure, Antoine, Lazor, Romain, Naccache, Jean-Marc, Jouneau, Stéphane, Nunes, Hilario, Reynaud-Gaubert, Martine, Le Borgne, Aurélie, Boutboul, David, Ba, Ibrahima, Boileau, Catherine, Crestani, Bruno, Kannengiesser, Caroline, and Borie, Raphaël

Published
2022
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44. Endoscopic Management of Idiopathic Tracheal Stenosis

Author

Perotin, Jeanne-Marie, Jeanfaivre, Thierry, Thibout, Yoann, Jouneau, Stéphane, Lena, Hervé, Dutau, Hervé, Ramon, Philippe, Lorut, Christine, Noppen, Marc, Vergnon, Jean-Michel, Vallerand, Hervé, Merol, Jean-Claude, Marquette, Charles-Hugo, Lebargy, François, and Deslee, Gaëtan

Published
2011
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46. Granulomatosis with polyangiitis: endoscopic management of tracheobronchial stenosis: results from a multicentre experience

Author

Terrier, Benjamin, Dechartres, Agnès, Girard, Charlotte, Jouneau, Stéphane, Kahn, Jean-Emmanuel, Dhote, Robin, Lazaro, Estibaliz, Cabane, Jean, Papo, Thomas, Schleinitz, Nicolas, Cohen, Pascal, Begon, Edouard, Belenotti, Pauline, Chauveau, Dominique, Diot, Elisabeth, Généreau, Thierry, Hamidou, Mohamed, Hayem, Gilles, Le Guenno, Guillaume, Le Guern, Véronique, Michel, Marc, Moulis, Guillaume, Puéchal, Xavier, Rivière, Sophie, Samson, Maxime, Gonin, François, Le Jeunne, Claire, Corlieu, Pascal, Mouthon, Luc, and Guillevin, Loic

Published
2015
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48. Soluble CD163 is produced by monocyte-derived and alveolar macrophages, and is not associated with the severity of idiopathic pulmonary fibrosis.

Author

Chauvin, Pierre, Morzadec, Claudie, de Latour, Bertrand, Llamas-Gutierrez, Francisco, Luque-Paz, David, Jouneau, Stéphane, and Vernhet, Laurent

Subjects
ALVEOLAR macrophages, MACROPHAGE colony-stimulating factor, INTERSTITIAL lung diseases, MACROPHAGE activation, AGRANULOCYTOSIS, INFLAMMATION, IDIOPATHIC pulmonary fibrosis
Abstract

The soluble form of the membrane hemoglobin scavenger receptor CD163 (sCD163), released by shedding, is a strong marker for macrophage activation. Serum sCD163 levels rise in several acute inflammatory states and some fibrosing diseases. Monocyte-derived macrophages (MoDM) differentiated by macrophage colony-stimulating factor (M-MoDM) contribute to the pathophysiology of idiopathic pulmonary fibrosis (IPF), an irreversible and rapidly fatal interstitial lung disease. Since M-MoDM express high membrane CD163 levels, we thus postulated that sCD163 could be a relevant biomarker for macrophage activation in IPF. We found that M-MoDM constitutively released higher amounts of sCD163 (49.5 ± 24.5 ng/ml) than monocytes (0.45 ± 0.32 ng/ml) or MoDM differentiated with granulocyte macrophage-stimulating factor (2.24 ± 0.98 ng/ml). The basal production of sCD163 by M-MoDM was increased following stimulation with lipopolysaccharide (123.4 ± 54.9 ng/ml) or ATP (168.9 ± 41.8 ng/ml). The sCD163 release was controlled by metalloproteases but not through ADAM17 activation. Moreover, CD163-positive macrophages and sCD163 were detected in pulmonary tissues and alveolar fluids of Caucasian patients with IPF, respectively. IPF alveolar macrophages constitutively secreted sCD163 amounts (67.6 ± 44.6 ng/µg RNA) which were significantly higher than those released by alveolar macrophages isolated from controls (19.2 ± 7.6 ng/µg RNA) or patients with other interstitial lung disease (31.5 ± 16.6 ng/µg RNA). However, the concentrations of sCD163 in blood serum collected from 155 patients with IPF did not correlate with the severity of their disease. In conclusion, our results show that M-MoDM constituted a pertinent model to study the regulation of sCD163 production. Yet, serum sCD163 values could not provide a prognostic biomarker for IPF in our cohort. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss):: Clinical Characteristics And Long-Term Followup of the 383 Patients Enrolled in the French Vasculitis Study Group Cohort

Author

Comarmond, Cloé, Pagnoux, Christian, Khellaf, Mehdi, Cordier, Jean-François, Hamidou, Mohamed, Viallard, Jean-François, Maurier, François, Jouneau, Stéphane, Bienvenu, Boris, Puéchal, Xavier, Aumaître, Olivier, Le Guenno, Guillaume, Le Quellec, Alain, Cevallos, Ramiro, Fain, Olivier, Godeau, Bertrand, Seror, Raphaèle, Dunogué, Bertrand, Mahr, Alfred, Guilpain, Philippe, Cohen, Pascal, Aouba, Achille, Mouthon, Luc, and Guillevin, Loïc

Published
2013
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