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With the rise of digital devices, gaming has become both a pastime and part of the culture for young people. Teenagers use games to communicate, enjoy leisure time, and relieve stress. However, the maladaptive use of gaming can lead to difficulties in adolescents’ daily lives and school adjustment. Increasing adolescents’ self-regulation competencies can improve maladaptive gaming behaviors and help them use gaming adaptively. Therefore, this study examined the moderating effect of self-regulation on the impact of adolescent gaming behavior on school adjustment. This study considered 359 adolescent participants in South Korea. Data were analyzed using hierarchical regression to test the moderating effect. The results indicated that adolescents’ adaptive use of games significantly increased school adjustment. Self-regulation significantly moderated the negative effects of the maladaptive use of games on school adjustment. Furthermore, the results revealed that the groups with highly adaptive and maladaptive use of games had high school adjustment but low self-regulation, indicating that they required active intervention.

Previous studies have found that the use or development of theory in library and information science (LIS) research is comparatively low and may be trending downward. LIS has also been criticized for relying on theories imported from other disciplines rather than applying or developing theories from within. The theory of information worlds, a social information behavior theory originally introduced in 2008, represents a newer LIS theory whose level of adoption is understudied. This study features a systematic literature review of peer-reviewed research articles which cited or used the theory of information worlds from 2008 to early 2022 to identify trends related to levels of theory use, publication venues, author affiliations, countries, and collaborations, as well as research methods, topics, and populations. Findings suggest that both awareness and use of the theory of information worlds are positively trending, though at slower rates for higher levels of theory use, such as full applications of the theory to guide the collection and analysis of empirical data. The theory has also been used by researchers from around the world and across disciplines, most often with mixed and qualitative methods. While the growth of a new LIS theory is promising, the authors echo calls for increased use and development of the theory of information worlds, and other LIS theories more broadly, and as more interdisciplinary collaboration.

Accumulation of glucose/sugar results in the formation of reactive di-carbonyl compounds such as MGO and GO that interact with several amino acids and proteins to form toxic advanced glycation end products (AGEs). Induction of AGEs breakdown can control symptoms and severity in T2DM and other related complications like NAFLD where AGEs are the key players. Therefore, an AGE cross-link breaker has been suggested for preventing the onset/progression of NAFLD. In this study, we reported novel synthetic naphthalene-2-acyl thiazolium derivatives (KHAGs). Among synthesized KHAG derivatives, we observed that a novel KHAG-04, a 1,4-dimethoxynaphthalen-2-acyl thiazolium salt which is an analog of alagebrium, dramatically cleaves MGO/GO-AGE cross-links, and it also inhibited inflammation by lowering the level of nitric oxide production and IL-1β and TNF-α secretion in LPS and/or MGO-AGE–activated macrophage. Moreover, it also reduced FFA and MGO-AGE–induced lipogenesis in Hep-G2 cells. In mice, KHAG-04 significantly reduced the level of glyoxal in the liver, which was induced by DMC. Furthermore, KHAG-04 treatment significantly reduced blood glucose levels, lipid accumulation, and inflammation in the NAFLD/T2DM animal model. Novel KHAG-04–mediated induction of AGEs breakdown could be the possible reason for its anti-inflammatory, antihyperglycemic, and anti-lipidemic effects in cells and NAFLD in the T2DM animal model, respectively. Further research might explore the pharmacological efficacy and usefulness and consider the ability of this compound in the treatment strategy against various models of NAFLD in T2DM where MGO/GO-AGEs play a key role in the pathogenesis.

Even though Candida spp. are staying commonly on human skin, it is also an opportunistic pathogenic fungus that can cause candidiasis. The emergence of resistant Candida strains and the toxicity of antifungal agents have encouraged the development of new classes of potent antifungal agents. Novel naphthalen-2-acyl imidazolium salts (NAIMSs), especially 1,4-dialkoxy-NAIMS from 1,4-dihydroxynaphthalene, were prepared and evaluated for antifungal activity. Those derivatives showed prominent anti-Candida activity with a minimum inhibitory concentration (MIC) of 3.125 to 6.26 μg/mL in 24 h based on microdilution antifungal susceptibility test. Among the tested compounds, NAIMS 7c showed strongest antifungal activity with 3.125 μg/mL MIC value compared with miconazole which showed 12.5 μg/mL MIC value against Candida spp., and more importantly >100 μg/mL MIC value against C. auris. The production of reactive oxygen species (ROS) was increased and JC-1 staining showed the loss of mitochondrial membrane potential in C. albicans by treatment with NAIMS 7c. The increased release of ultraviolet (UV) absorbing materials suggested that NAIMS 7c could cause cell busting. The expression of apoptosis-related genes was induced in C. albicans by NAIMS 7c treatment. Taken together, the synthetic NAIMSs are of high interest as novel antifungal agents given further in vivo examination.

Accumulation of glucose/sugar results in the formation of reactive di-carbonyl compounds such as MGO and GO that interact with several amino acids and proteins to form toxic advanced glycation end products (AGEs). Induction of AGEs breakdown can control symptoms and severity in T2DM and other related complications like NAFLD where AGEs are the key players. Therefore, an AGE cross-link breaker has been suggested for preventing the onset/progression of NAFLD. In this study, we reported novel synthetic naphthalene-2-acyl thiazolium derivatives (KHAGs). Among synthesized KHAG derivatives, we observed that a novel KHAG-04, a 1,4-dimethoxynaphthalen-2-acyl thiazolium salt which is an analog of alagebrium, dramatically cleaves MGO/ GO-AGE cross-links, and it also inhibited inflammation by lowering the level of nitric oxide production and IL-1β and TNF-α secretion in LPS and/or MGOAGE– activated macrophage. Moreover, it also reduced FFA and MGOAGE– induced lipogenesis in Hep-G2 cells. In mice, KHAG-04 significantly reduced the level of glyoxal in the liver, which was induced by DMC. Furthermore, KHAG-04 treatment significantly reduced blood glucose levels, lipid accumulation, and inflammation in the NAFLD/T2DM animal model. Novel KHAG-04–mediated induction of AGEs breakdown could be the possible reason for its anti-inflammatory, antihyperglycemic, and anti-lipidemic effects in cells and NAFLD in the T2DM animal model, respectively. Further research might explore the pharmacological efficacy and usefulness and consider the ability of this compound in the treatment strategy against various models of NAFLD in T2DM where MGO/GO-AGEs play a key role in the pathogenesis. [ABSTRACT FROM AUTHOR]

The importance of cultural diversity and competency in library services has been gradually increasing along with rapid growth of international residents (3.3% of total population) in South Korea. Along with a multi-cultural population, marginalized communities including disabled persons, financially disadvantaged persons, and seniors over 65 years old are growing. To fulfill the South Korean government’s goal of becoming an Innovative Inclusive Nation, public libraries and librarians need to better prepare for these significant changes and work to become more socially inclusive. While librarians need to continuously promote cultural competence, empathy, communication and other critical skills through their professional development training, studies show that little of such training exists in South Korea. In this study, we review related literature and analyze three example cases of Virtual Reality (VR) simulations developed for service-oriented professions, nurses, dentists, and teachers, for the purposes of providing core foundations and best practices to guide the design and development of training programs for pre- and in-service librarians. Amid an ongoing pandemic, and the advent of the metaverse and Fourth Industrial Revolution, VR-based, online, and mixed face-to-face professional development are likely to become more in demand and will help librarians to become future ready and socially inclusive. [ABSTRACT FROM AUTHOR]

A seizure-paralysis repertoire characteristic of Drosophila "bang-sensitive" mutants can be evoked electroconvulsively in tethered flies, in which behavioral episodes are associated with synchronized spike discharges in different body parts. Flight muscle DLMs (dorsal longitudinal muscles) display a stereotypic sequence of initial and delayed bouts of discharges (ID and DD), interposed with giant fiber (GF) pathway failure and followed by a refractory period. We examined how seizure susceptibility and discharge patterns are modified in various K+ and Na+ channel mutants. Decreased numbers of Na+ channels in napts flies drastically reduced susceptibility to seizure induction, eliminated ID, and depressed DD spike generation. Mutations of different K+ channels led to differential modifications of the various components in the repertoire. Altered transient K+ currents in Sh133 and Hk mutants promoted ID induction. However, only Sh133 but not Hk mutations increased DD seizure and GF pathway failure durations. Surprisingly, modifications in sustained K+ currents in eag and Shab mutants increased thresholds for DD induction and GF pathway failure. Nevertheless, both eag and Shab, like Sh133, increased DD spike generation and recovery time from GF pathway failure. Interactions between channel mutations with the bang-sensitive mutation bss demonstrated the role of membrane excitability in stress-induced seizure-paralysis behavior. Seizure induction and discharges were suppressed by napts in bss nap double mutants, whereas Sh heightened seizure susceptibility in bss Sh133 and bss ShM double mutants. Our results suggest that individual seizure repertoire components reflect different neural network activities that could be differentially altered by mutations of specific ion channel subunits. [ABSTRACT FROM AUTHOR]

Dissertation work is traditionally a solo, perhaps isolating, endeavor. In qualitative content analysis in the social sciences, the student applies a codebook, whether of their own creation or an adaptation of an existing theory or framework, which is appropriate to their research context and method without collaborating with others. The theory of information worlds provides an analytical framework to analyze information behavior and use in social contexts without ascribing to or prescribing a particular methodology or approach. This article describes and discusses a novel collaborative effort to operationalize and develop codebooks for the theory of information worlds which was used across three methodologically diverse dissertations. Implications for methodology, pedagogy, and dissertation work are also discussed, with an emphasis on the ways in which a project such as this might inform the future teaching practices of doctoral students. [ABSTRACT FROM AUTHOR]