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Background: Necroptosis, a recently discovered programmed cell death, has been pathologically linked to various diseases and is thus a promising target for treating diseases. However, a comprehensive and objective report on the current status of entire necroptosis research is lacking. Therefore, this study aims to conduct a bibliometric analysis to quantify and identify the status quo and trending issues of necroptosis research in the last decade. Methods: Articles were acquired from the Web of Science Core Collection database. We used two bibliometric tools (CiteSpace and VOSviewer) to quantify and identify the individual impact and cooperation information by analyzing annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. Afterwards, we identified the trending research areas of necroptosis by analyzing the co-occurrence and burst of keywords and co-cited references. Results: From 2012 to 2021, a total of 3,111 research articles on necroptosis were published in 786 academic journals by 19,687 authors in 885 institutions from 82 countries/regions. The majority of publications were from China and the United States, of which the United States maintained the dominant position in necroptosis research; meanwhile, the Chinese Academy of Sciences and Ghent University were the most active institutions. Peter Vandenabeele published the most papers, while Alexei Degterev had the most co-citations. Cell Death & Disease published the most papers on necroptosis, while Cell was the top 1 co-cited journal, and the major area of these publications was molecular, biology, and immunology. High-frequency keywords mainly included those that are molecularly related (MLKL, TNF-alpha, NF-κB, RIPK3, RIPK1), pathological process related (cell-death, apoptosis, necroptosis, necrosis, inflammation), and disease related (cancer, ischemia/reperfusion injury, infection, carcinoma, Alzheimer's disease). Conclusion: Necroptosis research had a stable stepwise growth in the past decade. Current necroptosis studies focused on its cross-talk with other types of cell death, potential applications in disease treatment, and further mechanisms. Among them, the synergy with ferroptosis, further RIPK1/RIPK3/MLKL studies, its association with inflammation and oxidative stress and translational applications, and the therapeutic potential to treat cancer and neurodegenerative diseases are the trending research area. These might provide ideas for further research in the necroptosis field. [ABSTRACT FROM AUTHOR]

This article discusses the methodology quality of observational studies investigating the drug safety of Chinese patent medicine (CPM) using real-world data (RWD). The authors highlight the importance of safety evidence for CPM, given its widespread use in traditional Chinese medicine. The study finds that the methodology quality of these observational studies is inadequate, particularly in terms of addressing confounding, handling missing data, and conducting sensitivity analyses. The authors emphasize the need for improvements in these areas to ensure the validity of study findings. [Extracted from the article]

The short circuit response of voltage source converters (VSCs) could be significantly different from that of synchronous condensers (SCs) under unbalanced faults. This paper investigates the combined effect of VSC-based sources and synchronous condensers under grid unbalanced faults considering two groups of VSC fault-ride-through control strategies. It aims to provide an evaluation of typical control strategies and to explore the impact of equipping a synchronous condenser at the point of common coupling (PCC). By examining the combined short-circuit currents, PCC voltages, DC-side voltages, and system frequency responses, this study points out the merits and demerits of the examined control strategies, illustrates the benefits of synchronous condensers on mitigating the disadvantages of certain control strategies, and provides suggestions on selecting the control strategies for the VSC when incorporating a synchronous condenser at the PCC. [ABSTRACT FROM AUTHOR]

The short circuit response of a voltage source converter (VSC) under grid unbalanced faults mainly depends on the design of its control system. Due to the limited semiconductor overload capability, the short circuit current contributed by a VSC should be restricted within the limit for each phase. This might bring up challenges to the protection system of a converter-dominated power system. This paper derives a generic converter peak current limitation method for three different VSC control strategies. The impact of the control strategies and the combined impact of a VSC with a synchronous condenser on distance protection are evaluated using a commercial relay through hardware-in-the-loop (HIL) tests. Based on the test results, we propose to avoid using constant reactive power control strategy. It poses an adverse impact on the reliability and speed of distance protection regardless of the presence of a synchronous condenser at the point of common coupling, while constant active power and balanced current control strategies favor the performances of distance protection. [ABSTRACT FROM AUTHOR]

As an increasing amount of converter-based generation on power electronics is connected to power systems, transmission system operators are revising the grid-connection requirements to streamline the connectivity of the devices to maintain security of supply. Converter-based generation can behave significantly different from the traditional alternators under grid faults. In order to evaluate the potential impact of the future converter-based power systems on protective relays, it is necessary to consider diverse current control strategies of voltage-source converters (VSCs) under unbalanced faults as the performance of converters primarily depends on their control objectives. In this paper, current control strategies of VSCs under unbalanced faults for short-circuit power provision are reviewed in two groups, namely, power-characteristic-oriented and voltage-support-oriented control strategy, respectively. As the fault current provided by converters should be restricted within secure operation limits considering semiconductor capabilities, converter current limit issue is also discussed. [ABSTRACT FROM PUBLISHER]

This paper investigates the reactive power balance of the Zealand side of the Danish transmission system (DK2) by using QV-curves. The study is performed in cooperation with Energinet, who is the Danish transmission system operator (TSO). Firstly, this paper aims to map the reactive power balance with the current challenges in the system, which appears due to a decision of changing overhead lines in the scenic area to cables. Secondly, a method is derived for obtaining a comprehensive overview of the impacts that future projects might have on the system. By dividing the transmission system into smaller areas, it is possible to analyze how the reactive power will affect the voltage; moreover, it is favorable to analyze and handle the challenges in the reactive power balance locally. This helps the TSO to quickly determine the lack of reactive power devices and issues that might occur in future expansions of the system. For this paper, a full-scale model of DK2 and SCADA-data has been utilized. It covers the period from 01-01-2016 to 20-08-2017 between the TSO and the Distribution System Operator (DSO). The studies have shown how the location of the wind production will create issues in the reactive power balance. [ABSTRACT FROM AUTHOR]

Voltage source converters (VSCs) are able to provide both positive- and negative-sequence short circuit currents under unbalanced faults. Their short circuit responses can be significantly different from those of conventional synchronous generators. This paper developed a static fault analysis method by considering dual-sequence current control of VSCs under unbalanced faults where VSCs are treated as voltage-dependent current sources in both positive- and negative-sequence networks. Since the control strategy of VSCs varies, flexible parameters are included in the model to reflect their diverse short circuit behaviours. The proposed method is verified through a modified IEEE 9-bus system and a simplified western Danish power system with real time simulations. This analytical method can be used to help understand and evaluate the impact of dual-sequence current control of VSCs on future converter-dominated power systems. [ABSTRACT FROM AUTHOR]

Aims: To evaluate the relationship of the healthy eating index-2015 (HEI-2015) with abdominal aortic calcification (AAC) in US adults., Methods: We conducted a cross-sectional study with data extracted from the National Health and Nutrition Examination Survey (NHANES). AAC score was measured using the scoring system of Kauppila (AAC-24) and Schousboe (AAC-8). HEI-2015, which was used for evaluating compliance with Dietary Guidelines for Americans (DGA), was calculated through two rounds of 24-h recall interviews. HEI-2015 was categorized as inadequate (<50), average (50~70), and optimal (≥70) groups for analysis, while the AAC-24 score was grouped by whether the score was >0. Weighted multiple regression analyses were conducted to estimate the association of HEI-2015 with AAC score and the presence of AAC. Moreover, smooth curve fittings, based on a generalized additive model (GAM), were applied to evaluate a possible non-linear relationship. Sensitivity analysis and subgroup analysis were performed to provide more supporting information., Results: A total of 2,704 participants were included in the study (mean age, 57.61 ± 11.40 years; 51.78% were women). The mean score of HEI-2015 was 56.09 ± 13.40 (41.33 ± 6.28, 59.44 ± 5.54, and 76.90 ± 5.37 for inadequate, average, and optimal groups, respectively). After adjusting for covariates, higher HEI-2015 was associated with decreased AAC score (AAC-24: β = -0.121, 95% CI: -0.214, -0.028, P = 0.010; AAC-8: β= -0.054, 95% CI: -0.088, -0.019, P = 0.003) and lower risk of AAC (OR = 0.921, 95% CI: 0.855, 0.993, P = 0.031). Among the components of HEI-2015, a higher intake of fruits, greens, and beans was associated with a lower AAC score. Subgroup analysis showed that an inverse association of HEI-2015 with AAC score existed among different groups., Conclusion: The study presented that higher HEI-2015 was related to a lower AAC score and decreased risk of having AAC, indicating that greater compliance with 2015-2020 DGA, assessed by HEI-2015, might be beneficial for preventing vascular calcification and CVD among US adults., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Jia, Zhang, Ma, Zhang, Zhao, Wang and Xu.)

Objective: To evaluate the association between dietary inflammatory index (DII) and Atherosclerotic cardiovascular disease (ASCVD) among U.S. adults., Methods: We collected data from National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. Adults who reported complete information to diagnose ASCVD and calculate DII were included. We used three models to differentially adjust the covariates, including age, sex, race or ethnicity, education level, smoking status, poverty, insurance, body mass index, hyperlipemia, hypertension, and diabetes. Logistic regression was used to estimate the Odds Ratio (OR) and 95% confidence interval (95% CI) for ASCVD grouped by DII deciles. We additionally conducted spline smoothing with the generalized additive model (GAM) and the log-likelihood ratio to examine the non-linear relationship between DII and ASCVD. If exists, the segmented linear regression will be used to detect the cutoff point. The subgroup analyses were stratified by various atherosclerotic cardiovascular diseases (i.e., CHD, angina, heart attack, and stroke) and sex., Results: A total of 48,733 participants (mean age, 47.13 ± 0.19 years) with 51.91% women were enrolled, of which 5,011 were diagnosed with ASCVD. In the crude model, participants in the five highest deciles (D6, 7, 8, 9, and 10) of DII score had a significantly higher risk of having ASCVD compared to those in the first decile. In the fully adjusted model, those in the tenth decile [OR = 1.47, 95% CI = (1.18,1.84)] of DII had a significantly increased risk of ASCVD compared to the first decile. Notably, when DII is above 3, the ASCVD risk increased by 41% for each one increase in DII [OR = 1.41, 95% CI = (1.15,1.73)]. This relationship was more pronounced in females., Conclusion: Our study revealed a positive and non-linearly association between DII and ASCVD in U.S. adults. This relationship was more pronounced in females. The findings provide a reference for future research and diet recommendations., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Zhang, Jia, Lai, Wang, Chen, Tian, Liu, Li, Ju and Xu.)