120 results on '"Ji, Zhiwei"'
Search Results
2. Characteristics of Elastic Wave Propagation in Fluid-Saturated Porous Media Based on the Model of Soil Mechanics
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Zhang, Bo, Chen, Xueliang, Qiu, Lijun, Dong, Jie, Zhou, Zhanxue, Ji, Zhiwei, and Liang, Lingyu
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- 2023
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3. Single-channel EEG automatic sleep staging based on transition optimized HMM
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Huang, Jing, Ren, Lifeng, Ji, Zhiwei, and Yan, Ke
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- 2022
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4. Automated CT pancreas segmentation for acute pancreatitis patients by combining a novel object detection approach and U-Net
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Deng, Yang, Lan, Lan, You, Lei, Chen, Kai, Peng, Li, Zhao, Weiling, Song, Bin, Wang, Yi, Ji, Zhiwei, and Zhou, Xiaobo
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- 2023
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5. Uncertainties in Prediction of Near-Fault Long-Period Ground Motion: An Application to the 1970 Tonghai Earthquake (Ms 7.8)
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Ji, Zhiwei, Li, Zongchao, Chen, Xueliang, Li, Tiefei, Wu, Qing, Zhang, Bo, Li, Qi, and Huang, Ting
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- 2022
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6. Simulation of strong earthquake characteristics of a scenario earthquake (MS7.5) based on the enlightenment of 2022 MS6.9 earthquake in Menyuan
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Ji, Zhiwei, Li, Zongchao, Gao, Mengtan, Sun, Jize, and Guo, Xiangyun
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- 2022
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7. A space-embedding strategy for anomaly detection in multivariate time series
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Ji, Zhiwei, Wang, Yi, Yan, Ke, Xie, Xiaojun, Xiang, Yang, and Huang, Jing
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- 2022
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8. Cross-situation consistency of mobile App users' psychological needs.
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Sun, Zaoyi, Zhang, Pei, Ji, Zhiwei, Chen, Chuansheng, Wan, Qun, and Qian, Xiuying
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MD Multidisciplinary ,General Science & Technology - Abstract
Previous studies showed that individuals' traits could be used to explain the similarity of behavioral patterns across different occasions. Such studies have typically focused on personality traits, and have not been extended to psychological needs. Our study used a large dataset of 1,715,078 anonymous users' App usage records to examine whether the individual's needs-based profiles of App usage were consistent across different situations (as indexed by categories of App functions). Results showed a high level of consistency across situations in a user's choice of Apps based on the needs the Apps could satisfy. These results provide clear evidence in support of cross-category App recommendation systems.
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- 2019
9. [formula omitted]-size partial reduct: Positive region optimization for attribute reduction
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Xie, Xiaojun, Gu, Xingjian, Li, Yanbin, and Ji, Zhiwei
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- 2021
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10. Multi-scale modeling for systematically understanding the key roles of microglia in AD development
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Ji, Zhiwei, Liu, Changan, Zhao, Weiling, Soto, Claudio, and Zhou, Xiaobo
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- 2021
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11. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer
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Kim, Eunju, Kim, Yoon-Jin, Ji, Zhiwei, Kang, Jin Muk, Wirianto, Marvin, Paudel, Keshav Raj, Smith, Joshua A., Ono, Kaori, Kim, Jin-Ah, Eckel-Mahan, Kristin, Zhou, Xiaobo, Lee, Hyun Kyoung, Yoo, Ji Young, Yoo, Seung-Hee, and Chen, Zheng
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- 2022
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12. A novel computational approach for discord search with local recurrence rates in multivariate time series
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Hu, Min, Feng, Xiaowei, Ji, Zhiwei, Yan, Ke, and Zhou, Shengchen
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- 2019
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13. Semi-supervised learning for early detection and diagnosis of various air handling unit faults
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Yan, Ke, Zhong, Chaowen, Ji, Zhiwei, and Huang, Jing
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- 2018
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14. ULDNA: integrating unsupervised multi-source language models with LSTM-attention network for high-accuracy protein–DNA binding site prediction.
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Zhu, Yi-Heng, Liu, Zi, Liu, Yan, Ji, Zhiwei, and Yu, Dong-Jun
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LANGUAGE models ,BINDING sites ,DNA-protein interactions ,DRUG discovery ,AMINO acid sequence ,POLYMER networks - Abstract
Efficient and accurate recognition of protein–DNA interactions is vital for understanding the molecular mechanisms of related biological processes and further guiding drug discovery. Although the current experimental protocols are the most precise way to determine protein–DNA binding sites, they tend to be labor-intensive and time-consuming. There is an immediate need to design efficient computational approaches for predicting DNA-binding sites. Here, we proposed ULDNA, a new deep-learning model, to deduce DNA-binding sites from protein sequences. This model leverages an LSTM-attention architecture, embedded with three unsupervised language models that are pre-trained on large-scale sequences from multiple database sources. To prove its effectiveness, ULDNA was tested on 229 protein chains with experimental annotation of DNA-binding sites. Results from computational experiments revealed that ULDNA significantly improves the accuracy of DNA-binding site prediction in comparison with 17 state-of-the-art methods. In-depth data analyses showed that the major strength of ULDNA stems from employing three transformer language models. Specifically, these language models capture complementary feature embeddings with evolution diversity, in which the complex DNA-binding patterns are buried. Meanwhile, the specially crafted LSTM-attention network effectively decodes evolution diversity-based embeddings as DNA-binding results at the residue level. Our findings demonstrated a new pipeline for predicting DNA-binding sites on a large scale with high accuracy from protein sequence alone. [ABSTRACT FROM AUTHOR]
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- 2024
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15. On the three-dimensional flow evolution of a submerged synthetic jet with two circular orifices.
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Liu, Yingrui, Ji, Zhiwei, Wang, Hexin, Yu, Zhiqiang, and Shan, Feng
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THREE-dimensional flow , *ORIFICE plates (Fluid dynamics) , *STREAMFLOW velocity , *FLOW measurement , *TOMOGRAPHY , *SPATIAL resolution - Abstract
Synthetic jet has shown promising applications in active flow control in recent years. Tomographic particle image velocity (Tomo-PIV) is an emerging flow field measurement, which can obtain three-dimensional flow field with a high spatial and temporal resolution to help us better understand the evolution of synthetic jet. Therefore, this paper uses a time-resolved Tomo-PIV system to measure and analyze the three-dimensional flow evolution of a submerged two-orifice synthetic jet. The measurement is conducted for stroke length L = 1.9, 2.6, and 3.0 while keeping the orifice diameter D and the distance between the two orifices s constant. Research results reveal that the three-dimensional flow evolution can be described as follows: first, two independent vortex rings form at the outlet of the orifice plate; next, these two vortex rings interact with each other and merge into a non-circular vortex ring, which then undergoes axis switching and vortex reconnection, with the tendency of splitting into two vortex rings. Furthermore, the position where the axis-switching finishes coincides with the location of the maximum mean streamwise velocity. When the stroke length of the synthetic jet is 2.6, the non-circular vortex ring undergoes a collision of vortices after the completion of the axis switching, resulting in the phenomenon of vortex ring bifurcation. However, the non-circular vortex ring fails to split into two vortex rings for stroke lengths of 1.9 and 3. Moreover, the entrainment of the synthetic jet increases with the increase in stroke length. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Cost-sensitive and sequential feature selection for chiller fault detection and diagnosis
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Yan, Ke, Ma, Lulu, Dai, Yuting, Shen, Wen, Ji, Zhiwei, and Xie, Dongqing
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- 2018
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17. Carbon and nitrogen accumulation in the economic seaweed Gracilaria lemaneiformis affected by ocean acidification and increasing temperature
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Chen, Binbin, Zou, Dinghui, Du, Hong, and Ji, Zhiwei
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- 2018
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18. Automatic labeling of mobile apps by the type of psychological needs they satisfy
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Sun, Zaoyi, Ji, Zhiwei, Zhang, Pei, Chen, Chuansheng, Qian, Xiuying, Du, Xin, and Wan, Qun
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- 2017
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19. HNSPPI: a hybrid computational model combing network and sequence information for predicting protein–protein interaction.
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Xie, Shijie, Xie, Xiaojun, Zhao, Xin, Liu, Fei, Wang, Yiming, Ping, Jihui, and Ji, Zhiwei
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INFORMATION networks ,PROTEIN-protein interactions ,AMINO acid sequence ,DRUG discovery ,SUPERVISED learning ,POLYMER networks ,BLENDED learning - Abstract
Most life activities in organisms are regulated through protein complexes, which are mainly controlled via Protein–Protein Interactions (PPIs). Discovering new interactions between proteins and revealing their biological functions are of great significance for understanding the molecular mechanisms of biological processes and identifying the potential targets in drug discovery. Current experimental methods only capture stable protein interactions, which lead to limited coverage. In addition, expensive cost and time consuming are also the obvious shortcomings. In recent years, various computational methods have been successfully developed for predicting PPIs based only on protein homology, primary sequences of protein or gene ontology information. Computational efficiency and data complexity are still the main bottlenecks for the algorithm generalization. In this study, we proposed a novel computational framework, HNSPPI, to predict PPIs. As a hybrid supervised learning model, HNSPPI comprehensively characterizes the intrinsic relationship between two proteins by integrating amino acid sequence information and connection properties of PPI network. The experimental results show that HNSPPI works very well on six benchmark datasets. Moreover, the comparison analysis proved that our model significantly outperforms other five existing algorithms. Finally, we used the HNSPPI model to explore the SARS-CoV-2-Human interaction system and found several potential regulations. In summary, HNSPPI is a promising model for predicting new protein interactions from known PPI data. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Accelerating smooth molecular surface calculation
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Yan, Ke, Cheng, Ho-Lun, Ji, Zhiwei, Zhang, Xin, and Lu, Huijuan
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- 2017
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21. Predicting dynamic deformation of retaining structure by LSSVR-based time series method
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Ji, Zhiwei, Wang, Bing, Deng, SuPing, and You, Zhuhong
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- 2014
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22. Evolution of the PB1 gene of human influenza A (H3N2) viruses circulating between 1968 and 2019.
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Sun, Tongtong, Guo, Yanna, Zhao, Lingcai, Fan, Menglu, Huang, Nan, Tian, Miao, Liu, Qingzheng, Huang, Jingjin, Liu, Zhiyuan, Zhao, Yongzhen, Ji, Zhiwei, and Ping, Jihui
- Subjects
PANDEMICS ,INFLUENZA ,COVID-19 ,AVIAN influenza A virus ,HUMAN genes ,INFLUENZA A virus, H3N2 subtype ,INFLUENZA A virus ,INFLUENZA viruses - Abstract
One avian H3N2 influenza virus, providing its PB1 and HA segments, reassorted with one human H2N2 virus and caused a pandemic outbreak in 1968, killing over 1 million people. After its introduction to humanity, the pandemic H3N2 virus continued adapting to humans and has resulted in epidemic outbreaks every influenza season. To understand the functional roles of the originally avian PB1 gene in the circulating strains of human H3N2 influenza viruses, we analyzed the evolution of the PB1 gene in all human H3N2 isolates from 1968 to 2019. We found several specific residues dramatically changed around 2002–2009 and remained stable through to 2019. Then, we verified the functions of these PB1 mutations in the genetic background of the early pandemic virus, A/Hong Kong/1/1968(HK/68), as well as a recent seasonal strain, A/Jiangsu/34/2016 (JS/16). The PB1 V709I or PB1 V113A/K586R/D619N/V709I induced higher polymerase activity of HK/68 in human cells. And the four mutations acted cooperatively that had an increased replication capacity in vitro and in vivo at an early stage of infection. In contrast, the backward mutant, A113V/R586K/N619D/I709V, reduced polymerase activity in human cells. The PB1 I709V decreased viral replication in vitro, but this mutant only showed less effect on mice infection experiment, which suggested influenza A virus evolved in human host was not always consisted with highly replication efficiency and pathogenicity in other mammalian host. Overall, our results demonstrated that the identified PB1 mutations contributed to the viral evolution of human influenza A (H3N2) viruses. [ABSTRACT FROM AUTHOR]
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- 2022
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23. A Novel Computational Framework for Precision Diagnosis and Subtype Discovery of Plant With Lesion.
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Xia, Fei, Xie, Xiaojun, Wang, Zongqin, Jin, Shichao, Yan, Ke, and Ji, Zhiwei
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PLANT identification ,COMPUTER vision ,FOOD shortages ,SYMPTOMS ,DIAGNOSIS ,PLANT diseases - Abstract
Plants are often attacked by various pathogens during their growth, which may cause environmental pollution, food shortages, or economic losses in a certain area. Integration of high throughput phenomics data and computer vision (CV) provides a great opportunity to realize plant disease diagnosis in the early stage and uncover the subtype or stage patterns in the disease progression. In this study, we proposed a novel computational framework for plant disease identification and subtype discovery through a deep-embedding image-clustering strategy, Weighted Distance Metric and the t-stochastic neighbor embedding algorithm (WDM-tSNE). To verify the effectiveness, we applied our method on four public datasets of images. The results demonstrated that the newly developed tool is capable of identifying the plant disease and further uncover the underlying subtypes associated with pathogenic resistance. In summary, the current framework provides great clustering performance for the root or leave images of diseased plants with pronounced disease spots or symptoms. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Multivariate Air Quality Forecasting With Nested Long Short Term Memory Neural Network.
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Jin, Ning, Zeng, Yongkang, Yan, Ke, and Ji, Zhiwei
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Artificial intelligence-based air quality index (AQI) forecasting is a hot research topic in the fields of sustainable and smart industrial environment design. There are mainly two obstacles that hinder the existing machine learning (ML) and deep learning (DL) technologies providing accurate forecasting results to protect the environment, which include the intercorrelation between different AQI components and the highly volatile AQI pattern changes. In this article, a novel DL framework combining multiple nested long short term memory networks (MTMC-NLSTM) is proposed for accurate AQI forecasting enlightened with the federated learning. The performance of the proposed MTMC-NLSTM model is compared with conventional ML models, DL methods, as well as hybrid DL models. The experimental results show that the performance of the proposed method is superior to those of all compared models. [ABSTRACT FROM AUTHOR]
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- 2021
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25. A Novel Deep Learning Approach for Anomaly Detection of Time Series Data.
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Ji, Zhiwei, Gong, Jiaheng, and Feng, Jiarui
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ANOMALY detection (Computer security) , *TIME series analysis , *DEEP learning , *TRAFFIC monitoring - Abstract
Anomalies in time series, also called "discord," are the abnormal subsequences. The occurrence of anomalies in time series may indicate that some faults or disease will occur soon. Therefore, development of novel computational approaches for anomaly detection (discord search) in time series is of great significance for state monitoring and early warning of real-time system. Previous studies show that many algorithms were successfully developed and were used for anomaly classification, e.g., health monitoring, traffic detection, and intrusion detection. However, the anomaly detection of time series was not well studied. In this paper, we proposed a long short-term memory- (LSTM-) based anomaly detection method (LSTMAD) for discord search from univariate time series data. LSTMAD learns the structural features from normal (nonanomalous) training data and then performs anomaly detection via a statistical strategy based on the prediction error for observed data. In our experimental evaluation using public ECG datasets and real-world datasets, LSTMAD detects anomalies more accurately than other existing approaches in comparison. [ABSTRACT FROM AUTHOR]
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- 2021
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26. Systematically understanding the immunity leading to CRPC progression.
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Ji, Zhiwei, Zhao, Weiling, Lin, Hui-Kuan, and Zhou, Xiaobo
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TRAILS , *IMMUNITY , *PROSTATE cancer , *TUMOR growth , *DEVELOPMENTAL biology , *MULTISCALE modeling - Abstract
Prostate cancer (PCa) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death in American men. Androgen deprivation therapy (ADT) has become a standard treatment strategy for advanced PCa. Although a majority of patients initially respond to ADT well, most of them will eventually develop castration-resistant PCa (CRPC). Previous studies suggest that ADT-induced changes in the immune microenvironment (mE) in PCa might be responsible for the failures of various therapies. However, the role of the immune system in CRPC development remains unclear. To systematically understand the immunity leading to CRPC progression and predict the optimal treatment strategy in silico, we developed a 3D Hybrid Multi-scale Model (HMSM), consisting of an ODE system and an agent-based model (ABM), to manipulate the tumor growth in a defined immune system. Based on our analysis, we revealed that the key factors (e.g. WNT5A, TRAIL, CSF1, etc.) mediated the activation of PC-Treg and PC-TAM interaction pathways, which induced the immunosuppression during CRPC progression. Our HMSM model also provided an optimal therapeutic strategy for improving the outcomes of PCa treatment. [ABSTRACT FROM AUTHOR]
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- 2019
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27. Fast and Accurate Classification of Time Series Data Using Extended ELM: Application in Fault Diagnosis of Air Handling Units.
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Yan, Ke, Ji, Zhiwei, Lu, Huijuan, Huang, Jing, Shen, Wen, and Xue, Yu
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FAULT diagnosis , *TIME series analysis , *SERVER farms (Computer network management) , *KALMAN filtering , *MACHINE learning - Abstract
The extreme learning machine (ELM) is famous for its single hidden-layer feed-forward neural network which results in much faster learning speed comparing with traditional machine learning techniques. Moreover, extensions of ELM achieve stable classification performances for imbalanced data. In this paper, we introduce a hybrid method combining the extended Kalman filter (EKF) with cost-sensitive dissimilar ELM (CS-D-ELM). The raw data are preprocessed by EKF to produce inputs for the CS-D-ELM classifier. Experimental results show that the proposed method is more suitable for real-time fault diagnosis of air handling units than traditional approaches. [ABSTRACT FROM AUTHOR]
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- 2019
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28. The different responses of growth and photosynthesis to NH4+ enrichments between Gracilariopsis lemaneiformis and its epiphytic alga Ulva lactuca grown at elevated atmospheric CO2.
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Ji, Zhiwei, Zou, Dinghui, Gong, Jingyu, Liu, Chunxiang, Ye, Changpeng, and Chen, Yuning
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ULVA ,ATMOSPHERIC carbon dioxide ,ALGAE ,EUTROPHICATION ,PHOTOSYNTHESIS ,ALGAL growth - Abstract
We investigated how elevated CO 2 affects the responses of Gracilariopsis lemaneiformis and Ulva lactuca to NH 4
+ enrichments. All algae were incubated under four nutritional conditions (zero addition, 100, 500, and 2500 μM NH 4+ ), and two CO 2 levels (390 ppm and 1000 ppm). The growth, photosynthesis, and soluble protein contents of both species increased under the eutrophication condition (100 μM NH 4+ ). However, the growth and carotenoid contents of the two species declined when NH 4+ concentration increased. Under the super eutrophication condition (2500 μM NH 4+ ), all indexes measured in G. lemaneiformis were suppressed, while the growth and photosynthesis in U. lactuca changed indistinctively, both compared with the control. Moreover, under the super eutrophication condition, elevated CO 2 reduced the suppression in the growth of G. lemaneiformis , but decreased the growth of U. lactuca. Nonetheless, G. lemaneiformis displayed much lower growth rates than U. lactuca under the super eutrophication and elevated CO 2 condition. • Responses of two algal species to NH 4+ and CO 2 enrichments were investigated. • 100 μmol L−1 NH 4+ enhanced growth and photosynthesis in both algal species. • 2500 μmol L−1 NH 4+ was toxic to Gracilariopsis lemaneiformis but not Ulva lactuca. • Elevated CO 2 reduced the toxicity of 2500 μmol L−1 NH 4+ to G. lemaneiformis. [ABSTRACT FROM AUTHOR]- Published
- 2019
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29. Modern Machine Learning Techniques for Univariate Tunnel Settlement Forecasting: A Comparative Study.
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Hu, Min, Li, Wei, Yan, Ke, Ji, Zhiwei, and Hu, Haigen
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ARTIFICIAL neural networks ,TUNNEL design & construction ,MACHINE learning ,FORECASTING ,PARTICLE swarm optimization ,COMPARATIVE studies - Abstract
Tunnel settlement commonly occurs during the tunnel construction processes in large cities. Existing forecasting methods for tunnel settlements include model-based approaches and artificial intelligence (AI) enhanced approaches. Compared with traditional forecasting methods, artificial neural networks can be easily implemented, with high performance efficiency and forecasting accuracy. In this study, an extended machine learning framework is proposed combining particle swarm optimization (PSO) with support vector regression (SVR), back-propagation neural network (BPNN), and extreme learning machine (ELM) to forecast the surface settlement for tunnel construction in two large cities of China P.R. Based on real-world data verification, the PSO-SVR method shows the highest forecasting accuracy among the three proposed forecasting algorithms. [ABSTRACT FROM AUTHOR]
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- 2019
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30. The impact of elevated atmospheric CO2 on cadmium toxicity in Pyropia haitanensis (Rhodophyta).
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Ma, Haiying, Zou, Dinghui, Wen, Jiayi, Ji, Zhiwei, Gong, Jingyu, and Liu, Chunxiang
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CADMIUM analysis ,OCEAN acidification ,ELECTRON transport ,ELECTRON mobility ,OXYGEN - Abstract
Cadmium is one of the major heavy metal pollutions in coastal waters, and it is well known that cadmium at trace concentration is toxic to macroalgae. Change in marine carbonate system and ocean acidification caused by elevated atmospheric CO
2 also alter physiological characteristics of macroalgae. However, less research is focused on the combined impacts of elevated CO2 and cadmium pollution on the growth and physiology in macroalgae. In this study, the maricultivated macroalga Pyropia haitanensis (Rhodophyta) was cultured at three levels of Cd2+ (control, 4 and 12 mg L−1 ) and two concentrations of CO2 , the ambient CO2 (AC, 410 ppm) and elevated CO2 (HC, 1100 ppm). The results showed that 12 mg L−1 Cd2+ significantly suppressed the relative growth rate and superoxide dismutase activity in AC-grown P. haitanensis, while such inhibition extents by Cd2+ were alleviated in HC-grown algae. Cd2+ had no effects on efficiency of electron transport (α) and maximum electron transport rate (ETRmax ), but α was increased by elevated CO2 . Cd2+ dramatically suppressed the maximum net photosynthesis oxygen evolution rate (NPRm ) and the minimum saturation irradiance (Ik ) when the algal thalli were grown at AC, while such suppression of NPRm by Cd2+ was much decreased when the thalli were grown at HC. Collectively, our results suggested that elevated CO2 would alleviate Cd2+ toxicity on P. haitanensis. [ABSTRACT FROM AUTHOR]- Published
- 2018
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31. Genome-Wide Association and Mechanistic Studies Indicate That Immune Response Contributes to Alzheimer's Disease Development.
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Liu, Changan, Chyr, Jacqueline, Zhao, Weiling, Xu, Yungang, Ji, Zhiwei, Tan, Hua, Soto, Claudio, and Zhou, Xiaobo
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ALZHEIMER'S disease ,ETIOLOGY of dementia ,IMMUNE response ,SINGLE nucleotide polymorphisms ,CEREBROSPINAL fluid - Abstract
Alzheimer's disease (AD) is the most common cause of dementia. Although genome-wide association study (GWAS) have reported hundreds of single-nucleotide polymorphisms (SNPs) and genes linked to AD, the mechanisms about how these SNPs modulate the development of AD remain largely unknown. In this study, we performed GWAS for three traits in cerebrospinal fluid (CSF) and one clinical trait in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Our analysis identified five most significant AD related SNPs (FDR < 0.05) within or proximal to APOE, APOC1, and TOMM40. One of the SNPs was co-inherited with APOE allele 4, which is the most important genetic risk factor for AD. Three of the five SNPs were located in promoter or enhancer regions, and transcription factor (TF) binding affinity calculations showed dramatic changes (| Log2FC| > 2) of three TFs (PLAG1, RREB1, and ZBTB33) for two motifs containing SNPs rs2075650 and rs157580. In addition, our GWAS showed that both rs2075650 and rs157580 were significantly associated with the poliovirus receptor-related 2 (PVRL2) gene (FDR < 0.25), which is involved in spreading of herpes simplex virus (HSV). The altered regulation of PVRL2 may increase the susceptibility AD patients to HSV and other virus infections of the brain. Our work suggests that AD is a type of immune disorder driven by viral or microbial infections of the brain during aging. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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32. Integrating MicroRNA Expression Profiling Studies to Systematically Evaluate the Diagnostic Value of MicroRNAs in Pancreatic Cancer and Validate Their Prognostic Significance with the Cancer Genome Atlas Data.
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Zhang, Zhigang, Pan, Bing, Lv, Shaocheng, Ji, Zhiwei, Wu, Qian, Lang, Ren, He, Qiang, and Zhao, Xin
- Subjects
MICRORNA ,NON-coding RNA ,PANCREATIC cancer ,BIOMARKERS ,GENE expression - Abstract
Background/Aims: MicroRNAs (miRNAs) are promising biomarkers for pancreatic cancer (PaCa). However, systemic and unified evaluations of the diagnostic value of miRNAs are lacking. Therefore, we performed a systematic evaluation based on miRNA expression profiling studies.Methods: We obtained miRNA expression profiling studies from Gene Expression Omnibus (GEO) and ArrayExpress (AE) databases and calculated the pooled sensitivity, specificity, and summary area under a receiver operating characteristic (ROC) curve for every miRNA. According to the area under the curve (AUC), we identified the miRNAs with diagnostic potentiality and validated their prognostic role in The Cancer Genome Atlas (TCGA) data. Gene Ontology (GO) annotations and pathway enrichments of the target genes of the miRNAs were evaluated using bioinformatics tools.Results: Ten miRNA expression profiling studies including 958 patients were used in this diagnostic meta-analysis. A total of 693 miRNAs were measured in more than 9 studies. The top 50 miRNAs with high predictive values for PaCa were identified. Among them, miR-130b had the best predictive value for PaCa (pooled sensitivity: 0.73 [95% confidence intervals (CI) 0.44-0.91], specificity: 0.81 [95% CI 0.59–0.93], and AUC: 0.84 [95% CI 0.73–0.95]). We identified nine miRNAs (miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301) associated with overall survival in PaCa patients by combining our results with TCGA data. The results of a Cox model revealed that two miRNAs (miR-30a [hazard ratio (HR)=2.43, 95% CI 1.05-5.59; p=0.037] and miR-203 [HR=3.14, 95% CI 1.28-7.71; p=0.012]) were independent risk factors for prognosis in PaCa patients. In total, 405 target genes of the nine miRNAs were enriched with Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, and cancer-associated pathways such as Ras signaling pathways, phospholipase D signaling pathway, and AMP-activated protein kinase (AMPK) signaling pathway were revealed among the top 20 enriched pathways. There were significant negative correlations between miR-181b-1 and miR-125a expression levels and the methylation status of their promoter region.Conclusion: Our study performed a systematic evaluation of the diagnostic value of miRNAs based on miRNA expression profiling studies. We identified that miR-23a, miR-30a, miR-125a, miR-129-1, miR-181b-1, miR-203, miR-221, miR-222, and miR-1301 had moderate diagnostic value for PaCa and predicted overall survival in PaCa patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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33. Accelerating smooth molecular surface calculation.
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Yan, Ke, Cheng, Ho-Lun, Ji, Zhiwei, Zhang, Xin, and Lu, Huijuan
- Subjects
MOLECULAR dynamics ,COMPUTATIONAL biology ,DRUG design ,HYPERBOLOID ,VISUALIZATION - Abstract
This study proposes a novel approach, namely, skin flow complex algorithm (SFCA), to decompose the molecular skin surface into topological disks. The main contributions of SFCA include providing a simple decomposition and fast calculation of the molecular skin surface. Unlike most existing works which partition the molecular skin surface into sphere and hyperboloid patches, SFCA partitions the molecular skin surface into triangular quadratic patches and rectangular quadratic patches. Each quadratic patch is proven to be a topological disk and rendered by a rational Bézier patch. The skin surface is constructed by assembling all rational Bézier patches. Experimental results show that the SFCA is more efficient than most existing algorithms, and produces a triangulation of molecular skin surface which is decomposable, deformable, smooth, watertight and feature-preserved. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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34. Prediction of disease-linked miRNAs based on SODNMF-DM.
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Yang, Bingsheng, Li, Jian, Ji, Zhiwei, Ruan, Yaoping, Liu, Tongcun, and Feng, Hailin
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MICRORNA ,DATABASES ,FACTORIZATION - Abstract
MicroRNAs (miRNAs) play a crucial role in the life processes of organisms and affect the occurrence of many complex human diseases. Discovering potential links between diseases and miRNAs can aid in the prevention, diagnosis, and therapy of complex human diseases. Identifying diseases and miRNA associations through existing biological experiments is expensive, while scientific computing approaches can quickly and efficiently predict the potential links between diseases and miRNAs. We propose SODNMF-DM, a SODNMF based Disease-MiRNA matrix factorisation algorithm. The SODNMF-DM model exhibited an AUC of 0.9051 and an AUPR of 0.4774, respectively. To directly verify the effectiveness of SODNMF-DM, we studied three common human cancers. The experimental results showed that 25 of the top 30 potential miRNAs predicted by our proposed SODNMF-DM model were confirmed by HMDDv3.0 database. Conclusion: SODNMF-DM outperformed four other approaches in AUC and AUPR. In addition, our proposed approach exhibited good performance in practical cases. The approach presented in this study is thus expected to complement the field of biological research. • We fully consider disease similarity and miRNA similarity from multiple perspectives. • We use the alternating gradient descent method to ensure the stability of the solution. • The SODNMF-DM model has low overall complexity, simple operation and easy replication. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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35. Molecular Skin Surface-Based Transformation Visualization between Biological Macromolecules.
- Author
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Yan, Ke, Wang, Bing, Cheng, Holun, Ji, Zhiwei, Huang, Jing, and Gao, Zhigang
- Subjects
BIOMACROMOLECULES ,MOLECULAR biology ,BIOINFORMATICS ,DRUG design ,BINDING sites - Abstract
Molecular skin surface (MSS), proposed by Edelsbrunner, is a C
2 continuous smooth surface modeling approach of biological macromolecules. Compared to the traditional methods of molecular surface representations (e.g., the solvent exclusive surface), MSS has distinctive advantages including having no self-intersection and being decomposable and transformable. For further promoting MSS to the field of bioinformatics, transformation between different MSS representations mimicking the macromolecular dynamics is demanded. The transformation process helps biologists understand the macromolecular dynamics processes visually in the atomic level, which is important in studying the protein structures and binding sites for optimizing drug design. However, modeling the transformation between different MSSs suffers from high computational cost while the traditional approaches reconstruct every intermediate MSS from respective intermediate union of balls. In this study, we propose a novel computational framework named general MSS transformation framework (GMSSTF) between two MSSs without the assistance of union of balls. To evaluate the effectiveness of GMSSTF, we applied it on a popular public database PDB (Protein Data Bank) and compared the existing MSS algorithms with and without GMSSTF. The simulation results show that the proposed GMSSTF effectively improves the computational efficiency and is potentially useful for macromolecular dynamic simulations. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
36. Mathematical and Computational Modeling in Complex Biological Systems.
- Author
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Ji, Zhiwei, Yan, Ke, Li, Wenyang, Hu, Haigen, and Zhu, Xiaoliang
- Subjects
- *
BIOLOGICAL models , *COMPUTER simulation , *MATHEMATICAL models , *MATHEMATICS , *TUMORS , *BIOINFORMATICS , *THEORY , *PHENOMENOLOGICAL biology , *DISEASE progression - Abstract
The biological process and molecular functions involved in the cancer progression remain difficult to understand for biologists and clinical doctors. Recent developments in high-throughput technologies urge the systems biology to achieve more precise models for complex diseases. Computational and mathematical models are gradually being used to help us understand the omics data produced by high-throughput experimental techniques. The use of computational models in systems biology allows us to explore the pathogenesis of complex diseases, improve our understanding of the latent molecular mechanisms, and promote treatment strategy optimization and new drug discovery. Currently, it is urgent to bridge the gap between the developments of high-throughput technologies and systemic modeling of the biological process in cancer research. In this review, we firstly studied several typical mathematical modeling approaches of biological systems in different scales and deeply analyzed their characteristics, advantages, applications, and limitations. Next, three potential research directions in systems modeling were summarized. To conclude, this review provides an update of important solutions using computational modeling approaches in systems biology. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
37. Online fault detection methods for chillers combining extended kalman filter and recursive one-class SVM.
- Author
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Yan, Ke, Ji, Zhiwei, and Shen, Wen
- Subjects
- *
SUPPORT vector machines , *AIR conditioning , *BUILDING operation management , *KALMAN filtering , *RECURSIVE functions , *MAINTENANCE costs , *VENTILATION - Abstract
Automatic, accurate and online fault detection of heating ventilation air conditioning (HVAC) subsystems, such as chillers, is highly demanded in building management system (BMS) to prevent energy waste and high maintenance cost. However, most fault detection techniques require rich faulty training data which is usually unavailable. In this study, a novel hybrid method is proposed to detect faults for chiller subsystems without any faulty training data available, i.e. by training the normal data only. A hybrid feature selection algorithm is applied to the chiller dataset collected by ASHRAE project 1043-RP to select the most significant feature variables. An online classification framework is introduced by combining an Extended Kalman Filter (EKF) model and a recursive one-class support vector machine (ROSVM). Experiment results show that the proposing algorithm detects typical chiller faults with high accuracy rates and requires less feature variables compared to existing works. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
38. NMFBFS: A NMF-Based Feature Selection Method in Identifying Pivotal Clinical Symptoms of Hepatocellular Carcinoma.
- Author
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Ji, Zhiwei, Meng, Guanmin, Huang, Deshuang, Yue, Xiaoqiang, and Wang, Bing
- Subjects
- *
LIVER cancer , *LIVER cancer patients , *CHINESE medicine , *COMPARATIVE studies , *NONNEGATIVE matrices , *FACTORIZATION - Abstract
Background. Hepatocellular carcinoma (HCC) is a highly aggressive malignancy. Traditional Chinese Medicine (TCM), with the characteristics of syndrome differentiation, plays an important role in the comprehensive treatment of HCC. This study aims to develop a nonnegative matrix factorization- (NMF-) based feature selection approach (NMFBFS) to identify potential clinical symptoms for HCC patient stratification. Methods. The NMFBFS approach consisted of three major steps. Firstly, statistics-based preliminary feature screening was designed to detect and remove irrelevant symptoms. Secondly, NMF was employed to infer redundant symptoms. Based on NMF-derived basis matrix, we defined a novel similarity measurement of intersymptoms. Finally, we converted each group of redundant symptoms to a new single feature so that the dimension was further reduced. Results. Based on a clinical dataset consisting of 407 patient samples of HCC with 57 symptoms, NMFBFS approach detected 8 irrelevant symptoms and then identified 16 redundant symptoms within 6 groups. Finally, an optimal feature subset with 39 clinical features was generated after compressing the redundant symptoms by groups. The validation of classification performance shows that these 39 features obviously improve the prediction accuracy of HCC patients. Conclusions. Compared with other methods, NMFBFS has obvious advantages in identifying important clinical features of HCC. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
39. miR-193b Modulates Resistance to Doxorubicin in Human Breast Cancer Cells by Downregulating MCL-1.
- Author
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Long, Jingpei, Ji, Zhiwei, Jiang, Kai, Wang, Zhaoyang, and Meng, Guanmin
- Subjects
- *
RNA metabolism , *APOPTOSIS , *BREAST tumors , *DOXORUBICIN , *DRUG resistance , *RESEARCH methodology , *POLYMERASE chain reaction , *RESEARCH funding , *T-test (Statistics) , *TISSUE culture , *WESTERN immunoblotting , *DATA analysis software , *DESCRIPTIVE statistics , *IN vitro studies - Abstract
MicroRNAs (miRNAs) family, which is involved in cancer development, proliferation, apoptosis, and drug resistance, is a group of noncoding RNAs that modulate the expression of oncogenes and antioncogenes. Doxorubicin is an active cytotoxic agent for breast cancer treatment, but the acquisition of doxorubicin resistance is a common and critical limitation to cancer therapy. The aim of this study was to investigate whether miR-193b mediated the resistance of breast cancer cells to doxorubicin by targeting myeloid cell leukemia-1 (MCL-1). In this study, we found that miR-193b levels were significantly lower in doxorubicin-resistant MCF-7 (MCF-7/DOXR) cells than in the parental MCF-7 cells. We observed that exogenous miR-193b significantly suppressed the ability of MCF-7/DOXR cells to resist doxorubicin. It demonstrated that miR-193b directly targeted MCL-1 3'-UTR (3'-Untranslated Regions). Further studies indicated that miR-193b sensitized MCF-7/DOXR cells to doxorubicin through a mechanism involving the downregulation of MCL-1. Together, our findings provide evidence that the modulation of miR-193b may represent a novel therapeutic target for the treatment of breast cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
40. Detecting Protein-Protein Interactions with a Novel Matrix-Based Protein Sequence Representation and Support Vector Machines.
- Author
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You, Zhu-Hong, Li, Jianqiang, Gao, Xin, He, Zhou, Zhu, Lin, Lei, Ying-Ke, and Ji, Zhiwei
- Subjects
DATABASES ,DIFFUSION of innovations ,MOLECULAR biology ,PROTEINS ,RESEARCH funding ,STATISTICS ,STATISTICAL models - Abstract
Proteins and their interactions lie at the heart of most underlying biological processes. Consequently, correct detection of protein-protein interactions (PPIs) is of fundamental importance to understand the molecular mechanisms in biological systems. Although the convenience brought by high-throughput experiment in technological advances makes it possible to detect a large amount of PPIs, the data generated through these methods is unreliable and may not be completely inclusive of all possible PPIs. Targeting at this problem, this study develops a novel computational approach to effectively detect the protein interactions. This approach is proposed based on a novel matrix-based representation of protein sequence combined with the algorithm of support vector machine (SVM), which fully considers the sequence order and dipeptide information of the protein primary sequence. When performed on yeast PPIs datasets, the proposed method can reach 90.06% prediction accuracy with 94.37% specificity at the sensitivity of 85.74%, indicating that this predictor is a useful tool to predict PPIs. Achieved results also demonstrate that our approach can be a helpful supplement for the interactions that have been detected experimentally. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
41. Integrating Genomics and Proteomics Data to Predict Drug Effects Using Binary Linear Programming.
- Author
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Ji, Zhiwei, Su, Jing, Liu, Chenglin, Wang, Hongyan, Huang, Deshuang, and Zhou, Xiaobo
- Subjects
- *
PROTEOMICS , *PREDICTION models , *LINEAR programming , *CELLULAR signal transduction , *PHOSPHORYLATION , *STAUROSPORINE - Abstract
The Library of Integrated Network-Based Cellular Signatures (LINCS) project aims to create a network-based understanding of biology by cataloging changes in gene expression and signal transduction that occur when cells are exposed to a variety of perturbations. It is helpful for understanding cell pathways and facilitating drug discovery. Here, we developed a novel approach to infer cell-specific pathways and identify a compound's effects using gene expression and phosphoproteomics data under treatments with different compounds. Gene expression data were employed to infer potential targets of compounds and create a generic pathway map. Binary linear programming (BLP) was then developed to optimize the generic pathway topology based on the mid-stage signaling response of phosphorylation. To demonstrate effectiveness of this approach, we built a generic pathway map for the MCF7 breast cancer cell line and inferred the cell-specific pathways by BLP. The first group of 11 compounds was utilized to optimize the generic pathways, and then 4 compounds were used to identify effects based on the inferred cell-specific pathways. Cross-validation indicated that the cell-specific pathways reliably predicted a compound's effects. Finally, we applied BLP to re-optimize the cell-specific pathways to predict the effects of 4 compounds (trichostatin A, MS-275, staurosporine, and digoxigenin) according to compound-induced topological alterations. Trichostatin A and MS-275 (both HDAC inhibitors) inhibited the downstream pathway of HDAC1 and caused cell growth arrest via activation of p53 and p21; the effects of digoxigenin were totally opposite. Staurosporine blocked the cell cycle via p53 and p21, but also promoted cell growth via activated HDAC1 and its downstream pathway. Our approach was also applied to the PC3 prostate cancer cell line, and the cross-validation analysis showed very good accuracy in predicting effects of 4 compounds. In summary, our computational model can be used to elucidate potential mechanisms of a compound's efficacy. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
42. Systematically Studying Kinase Inhibitor Induced Signaling Network Signatures by Integrating Both Therapeutic and Side Effects.
- Author
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Shao, Hongwei, Peng, Tao, Ji, Zhiwei, Su, Jing, and Zhou, Xiaobo
- Subjects
KINASE inhibitors ,CELLULAR signal transduction ,DRUG therapy ,DRUG side effects ,BIOLOGICAL networks ,CELL proliferation ,MITOSIS - Abstract
Substantial effort in recent years has been devoted to analyzing data based large-scale biological networks, which provide valuable insight into the topologies of complex biological networks but are rarely context specific and cannot be used to predict the responses of cell signaling proteins to specific ligands or compounds. In this work, we proposed a novel strategy to investigate kinase inhibitor induced pathway signatures by integrating multiplex data in Library of Integrated Network-based Cellular Signatures (LINCS), e.g. KINOMEscan data and cell proliferation/mitosis imaging data. Using this strategy, we first established a PC9 cell line specific pathway model to investigate the pathway signatures in PC9 cell line when perturbed by a small molecule kinase inhibitor GW843682. This specific pathway revealed the role of PI3K/AKT in modulating the cell proliferation process and the absence of two anti-proliferation links, which indicated a potential mechanism of abnormal expansion in PC9 cell number. Incorporating the pathway model for side effects on primary human hepatocytes, it was used to screen 27 kinase inhibitors in LINCS database and PF02341066, known as Crizotinib, was finally suggested with an optimal concentration 4.6 uM to suppress PC9 cancer cell expansion while avoiding severe damage to primary human hepatocytes. Drug combination analysis revealed that the synergistic effect region can be predicted straightforwardly based on a threshold which is an inherent property of each kinase inhibitor. Furthermore, this integration strategy can be easily extended to other specific cell lines to be a powerful tool for drug screen before clinical trials. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
43. Inhibitory effect of selected hydrocolloids on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) formation in chemical models and beef patties.
- Author
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Yang, Hongmei, Ji, Zhiwei, Wang, Ru, Fan, Daming, Zhao, Yueliang, and Wang, Mingfu
- Subjects
- *
CHEMICAL models , *CARRAGEENANS , *AROMATIC amines , *PECTINS , *HYDROCOLLOIDS , *ALGINIC acid , *ALDOL condensation , *MAILLARD reaction - Abstract
• Inhibitory effects of eight hydrocolloids on the formation of PhIP were investigated. • 1% (w/w) of κ-carrageenan caused a decreased formation of PhIP by around 90 %. • κ-Carrageenan inhibited PhIP formation via trapping both creatinine and phenylacetaldehyde. 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP) is a mutagen and a rodent carcinogen mainly formed in thermally processed muscle foods. Hydrocolloids are widely used as thickeners, gelling agents and stabilizers to improve food quality in the food industry. In this study, the inhibitory effects of eight hydrocolloids on the formation of PhIP were investigated in both chemical models and beef patties. 1% (w/w) of carboxymethylcellulose V, κ-carrageenan, alginic acid, and pectin significantly reduced PhIP formation by 53 %, 54 %, 48 %, and 47 %, respectively in chemical models. In fried beef patties, κ-carrageenan appeared to be most capable of inhibiting PhIP formation among the eight tested hydrocolloids. 1% (w/w) of κ-carrageenan caused a decreased formation of PhIP by 90 %. 1% (w/w) of κ-carrageenan also significantly reduced the formation of other heterocyclic aromatic amines including MeIQx and 4,8-DiMeIQx by 64 % and 48 %, respectively in fried beef patties. Further mechanism study showed that κ-carrageenan addition decreased the PhIP precursor creatinine residue and reduced the content of Maillard reaction intermediates including phenylacetaldehyde and aldol condensation product in the chemical model. κ-Carrageenan may inhibit PhIP formation via trapping both creatinine and phenylacetaldehyde. The structures of adducts formed between κ-carrageenan and creatinine and κ-carrageenan and phenylacetaldehyde merits further study. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
44. Prediction of treatment efficacy for prostate cancer using a mathematical model.
- Author
-
Peng, Huiming, Zhao, Weiling, Tan, Hua, Ji, Zhiwei, Li, Jingsong, Li, King, and Zhou, Xiaobo
- Published
- 2016
- Full Text
- View/download PDF
45. Systemic modeling myeloma-osteoclast interactions under normoxic/hypoxic condition using a novel computational approach.
- Author
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Ji, Zhiwei, Wu, Dan, Zhao, Weiling, Peng, Huiming, Zhao, Shengjie, Huang, Deshuang, and Zhou, Xiaobo
- Subjects
- *
OSTEOCLASTS , *GROWTH factors ,BONE marrow cancer ,TUMOR genetics - Abstract
Interaction of myeloma cells with osteoclasts (OC) can enhance tumor cell expansion through activation of complex signaling transduction networks. Both cells reside in the bone marrow, a hypoxic niche. How OC-myeloma interaction in a hypoxic environment affects myeloma cell growth and their response to drug treatment is poorly understood. In this study, we i) cultured myeloma cells in the presence/absence of OCs under normoxia and hypoxia conditions and did protein profiling analysis using reverse phase protein array; ii) computationally developed an Integer Linear Programming approach to infer OC-mediated myeloma cell-specific signaling pathways under normoxic and hypoxic conditions. Our modeling analysis indicated that in the presence OCs, (1) cell growth-associated signaling pathways, PI3K/AKT and MEK/ERK, were activated and apoptotic regulatory proteins, BAX and BIM, down-regulated under normoxic condition; (2) β1 Integrin/FAK signaling pathway was activated in myeloma cells under hypoxic condition. Simulation of drug treatment effects by perturbing the inferred cell-specific pathways showed that targeting myeloma cells with the combination of PI3K and integrin inhibitors potentially (1) inhibited cell proliferation by reducing the expression/activation of NF-κB, S6, c-Myc, and c-Jun under normoxic condition; (2) blocked myeloma cell migration and invasion by reducing the expression of FAK and PKC under hypoxic condition. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
46. Identifying Potential Clinical Syndromes of Hepatocellular Carcinoma Using PSO-Based Hierarchical Feature Selection Algorithm.
- Author
-
Ji, Zhiwei and Wang, Bing
- Published
- 2014
- Full Text
- View/download PDF
47. Unsupervised learning for fault detection and diagnosis of air handling units.
- Author
-
Yan, Ke, Huang, Jing, Shen, Wen, and Ji, Zhiwei
- Subjects
- *
FAULT diagnosis , *AIR - Abstract
• This work applies an unsupervised learning technique, generative adversarial network (GAN), to deal with the imbalanced training dataset problem in data-driven AHU FDD. • Detailed steps of applying GAN to generate artificial faulty training samples are demonstrated and deeply analyzed. • A complete AHU FDD framework integrating extensions of GAN is proposed. • The existing GAN-based AHU FDD framework has been optimized. • Comprehensive experimental results are shown before and after applying GAN extensions to the traditional supervised FDD framework to illustrate the importance of GAN. Supervised learning techniques have witnessed significant successes in fault detection and diagnosis (FDD) for heating ventilation and air-conditioning (HVAC) systems. Despite the good performance, these techniques heavily rely on balanced datasets that contain a large amount of both faulty and normal data points. In real-world scenarios, however, it is often very challenging to collect a sufficient amount of faulty training samples that are necessary for building a balanced training dataset. In this paper, we introduce a framework that utilizes the generative adversarial network (GAN) to address the imbalanced data problem in FDD for air handling units (AHUs). To this end, we first show the necessary procedures of applying GAN to increase the number of faulty training samples in the training pool and re-balance the training dataset. The proposed framework then uses supervised classifiers to train the re-balanced datasets. Finally, we present a comparative study that illustrates the advantages of the proposed method for FDD of AHU with various evaluation metrics. Our work demonstrates the promising prospects of performing robust FDD of AHU with a limited number of faulty training samples. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
48. scFseCluster: a feature selection-enhanced clustering for single-cell RNA-seq data.
- Author
-
Wang Z, Xie X, Liu S, and Ji Z
- Subjects
- Animals, Single-Cell Analysis methods, Cluster Analysis, Sciuridae, Gene Expression Profiling methods, Single-Cell Gene Expression Analysis
- Abstract
Single-cell RNA sequencing (scRNA-seq) enables researchers to reveal previously unknown cell heterogeneity and functional diversity, which is impossible with bulk RNA sequencing. Clustering approaches are widely used for analyzing scRNA-seq data and identifying cell types and states. In the past few years, various advanced computational strategies emerged. However, the low generalization and high computational cost are the main bottlenecks of existing methods. In this study, we established a novel computational framework, scFseCluster, for scRNA-seq clustering analysis. scFseCluster incorporates a metaheuristic algorithm (Feature Selection based on Quantum Squirrel Search Algorithm) to extract the optimal gene set, which largely guarantees the performance of cell clustering. We conducted simulation experiments in several aspects to verify the performance of the proposed approach. scFseCluster performed very well on eight benchmark scRNA-seq datasets because of the optimal gene sets obtained using the Feature Selection based on Quantum Squirrel Search Algorithm. The comparative study demonstrated the significant advantages of scFseCluster over seven State-of-the-Art algorithms. In addition, our analysis shows that feature selection on high-variable genes can significantly improve clustering performance. In conclusion, our study demonstrates that scFseCluster is a highly versatile tool for enhancing scRNA-seq data clustering analysis., (© 2023 Wang et al.)
- Published
- 2023
- Full Text
- View/download PDF
49. Deep Transfer Learning for Cross-Species Plant Disease Diagnosis Adapting Mixed Subdomains.
- Author
-
Yan K, Guo X, Ji Z, and Zhou X
- Abstract
A deep transfer learning framework adapting mixed subdomains is proposed for cross-species plant disease diagnosis. Most existing deep transfer learning studies focus on knowledge transfer between highly correlated domains. These methods may fail to deal with domains that are poorly correlated. In this study, mixed domain images were generated from source and target image groups for improving the correlation between the mixed domain (training dataset) and the target domain (testing dataset). A subdomain alignment mechanism is employed to transfer knowledge from the mixed domain to the target domain. The proposed framework captures the fine-grained information more effectively. Extensive experiments were conducted and prove that the proposed method produces a more effective result compared with existing deep transfer learning technologies for poorly related subdomains.
- Published
- 2023
- Full Text
- View/download PDF
50. A Novel Feature Selection Strategy Based on Salp Swarm Algorithm for Plant Disease Detection.
- Author
-
Xie X, Xia F, Wu Y, Liu S, Yan K, Xu H, and Ji Z
- Abstract
Deep learning has been widely used for plant disease recognition in smart agriculture and has proven to be a powerful tool for image classification and pattern recognition. However, it has limited interpretability for deep features. With the transfer of expert knowledge, handcrafted features provide a new way for personalized diagnosis of plant diseases. However, irrelevant and redundant features lead to high dimensionality. In this study, we proposed a swarm intelligence algorithm for feature selection [salp swarm algorithm for feature selection (SSAFS)] in image-based plant disease detection. SSAFS is employed to determine the ideal combination of handcrafted features to maximize classification success while minimizing the number of features. To verify the effectiveness of the developed SSAFS algorithm, we conducted experimental studies using SSAFS and 5 metaheuristic algorithms. Several evaluation metrics were used to evaluate and analyze the performance of these methods on 4 datasets from the UCI machine learning repository and 6 plant phenomics datasets from PlantVillage. Experimental results and statistical analyses validated the outstanding performance of SSAFS compared to existing state-of-the-art algorithms, confirming the superiority of SSAFS in exploring the feature space and identifying the most valuable features for diseased plant image classification. This computational tool will allow us to explore an optimal combination of handcrafted features to improve plant disease recognition accuracy and processing time., (Copyright © 2023 Xiaojun Xie et al.)
- Published
- 2023
- Full Text
- View/download PDF
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