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A direct adaptive simultaneous perturbation stochastic approximation (DA SPSA) control system with a diagonal recurrent neural network (DRNN) controller is proposed. The DA SPSA control system with DRNN has simpler architecture and parameter vector size that is smaller than a feedforward neural network (FNN) controller. The simulation results show that it has a faster convergence rate than FNN controller. It results in a steady-state error and is sensitive to SPSA coefficients and termination condition. For trajectory control purpose, a hybrid control system scheme with a conventional PID controller is proposed. Index Terms - Diagonal recurrent neural network (DRNN), neural network controller (NNC), simultaneous perturbation stochastic approximation (SPSA).

Mechanical damage to middle ear components in blast exposure directly causes hearing loss, and the rupture of the tympanic membrane (TM) is the most frequent injury of the ear. However, it is unclear how the severity of injury graded by different patterns of TM rupture is related to the overpressure waveforms induced by blast waves. In the present study, the relationship between the TM rupture threshold and the impulse or overpressure waveform has been investigated in chinchillas. Two groups of animals were exposed to blast overpressure simulated in our lab under two conditions: open field and shielded with a stainless steel cup covering the animal head. Auditory brainstem response (ABR) and wideband tympanometry were measured before and after exposure to check the hearing threshold and middle ear function. Results show that waveforms recorded in the shielded case were different from those in the open field and the TM rupture threshold in the shielded case was lower than that in the open field (3.4 ± 0.7 vs. 9.1 ± 1.7 psi or 181 ± 1.6 vs. 190 ± 1.9 dB SPL). The impulse pressure energy spectra analysis of waveforms demonstrates that the shielded waveforms include greater energy at high frequencies than that of the open field waves. Finally, a 3D finite element (FE) model of the chinchilla ear was used to compute the distributions of stress in the TM and the TM displacement with impulse pressure waves. The FE model-derived change of stress in response to pressure loading in the shielded case was substantially faster than that in the open case. This finding provides the biomechanical mechanisms for blast induced TM damage in relation to overpressure waveforms. The TM rupture threshold difference between the open and shielded cases suggests that an acoustic role of helmets may exist, intensifying ear injury during blast exposure. [ABSTRACT FROM AUTHOR]

Hearing damage induced by blast exposure is a common injury in military personnel involved in most operation activities. Personal hearing protection devices such as earplugs come as a standard issue for Service members; however, it is not clear how to accurately evaluate the protection mechanisms of different hearing protection devices for blast overpressures (BOP). This paper reports a recent study on characterization of earplugs' protective function to BOP using human cadaver ears and 3D finite element (FE) model of the human ear. The cadaver ear mounted with pressure sensors near the eardrum (P1) and inside the middle ear (P2) and with an earplug inserted was exposed to BOP in the blast test chamber. P1, P2, and BOP at the ear canal entrance (P0) were simultaneously recorded. The measured P0 waveform was then applied at the ear canal entrance in the FE model and the P1 and P2 pressures were derived from the model. Both experiments and FE modeling resulted in the P1 reduction which represents the effective protection function of the earplug. Different earplugs showed variations in pressure waveforms transmitted to the eardrum, which determine the protection level of earplugs. [ABSTRACT FROM AUTHOR]

Rupture of the eardrum or tympanic membrane (TM) is one of the most frequent injuries of the ear after blast exposure. To understand how the TM damage is related to blast wave direction, human cadaver ears were exposed to blast waves along three directions: vertical, horizontal, and front with respect to the head. Blast overpressure waveforms were recorded at the ear canal entrance (P0), near the TM (P1), and inside the middle ear (P2). Thirteen to fourteen cadaver ears were tested in each wave direction and the TM rupture thresholds were identified. Results show that blast wave direction affected the peak P1/P0 ratio, TM rupture threshold, and energy flux distribution over frequencies. The front wave resulted in lowest TM rupture threshold and the horizontal wave resulted in highest P1/P0 ratio. To investigate the mechanisms of TM injury in relation to blast wave direction, the recorded P1 waveforms were applied onto the surface of the TM in a three-dimensional finite element model of the human ear and distributions of the stress in TM were calculated. Modeling results indicate that the sensitivity of TM stress change with respect to P1 pressure (dσ/dP1) may characterize mechanical damage of the TM in relation to blast waves. [ABSTRACT FROM AUTHOR]

Preference for the northern (N) ring conformation of the ribose moiety of adenine nucleotide 3',5'-bisphosphate antagonists of P2Y(1) receptors was established by using a ring-constrained methanocarba (a bicyclo[3.1.0]hexane) ring as a ribose substitute (Nandanan et al. J. Med. Chem. 2000, 43, 829-842). We have now combined the ring-constrained (N)-methanocarba modification with other functionalities at the 2-position of the adenine moiety. A new synthetic route to this series of bisphosphate derivatives was introduced, consisting of phosphorylation of the pseudoribose moiety prior to coupling with the adenine base. The activity of the newly synthesized analogues was determined by measuring antagonism of 2-methylthio-ADP-stimulated phospholipase C (PLC) activity in 1321N1 human astrocytoma cells expressing the recombinant human P2Y(1) receptor and by using the radiolabeled antagonist [(3)H]2-chloro-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine 3',5'-bisphosphate 5 in a newly developed binding assay in Sf9 cell membranes. Within the series of 2-halo analogues, the most potent molecule at the hP2Y(1) receptor was an (N)-methanocarba N(6)-methyl-2-iodo analogue 12, which displayed a K(i) value in competition for binding of [(3)H]5 of 0.79 nM and a K(B) value of 1.74 nM for inhibition of PLC. Thus, 12 is the most potent antagonist selective for the P2Y(1) receptor yet reported. The 2-iodo group was substituted with trimethyltin, thus providing a parallel synthetic route for the introduction of an iodo group in this high-affinity antagonist. The (N)-methanocarba-2-methylthio, 2-methylseleno, 2-hexyl, 2-(1-hexenyl), and 2-(1-hexynyl) analogues bound less well, exhibiting micromolar affinity at P2Y(1) receptors. An enzymatic method of synthesis of the 3',5'-bisphosphate from the corresponding 3'-monophosphate, suitable for the preparation of a radiophosphorylated analogue, was explored.