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Your search keyword '"Inoue, Osamu"' showing total 466 results
Start Over Author "Inoue, Osamu" Publication Type Academic Journals
466 results on '"Inoue, Osamu"'

7. Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI

Author

Inoue, Osamu, Osada, Makoto, Nakamura, Junya, Kazama, Fuminori, Shirai, Toshiaki, Tsukiji, Nagaharu, Sasaki, Tomoyuki, Yokomichi, Hiroshi, Dohi, Tomotaka, Kaneko, Makoto, Kurano, Makoto, Oosawa, Mitsuru, Tamura, Shogo, Satoh, Kaneo, Takano, Katsuhiro, Miyauchi, Katsumi, Daida, Hiroyuki, Yatomi, Yutaka, Ozaki, Yukio, and Suzuki-Inoue, Katsue

Published
2019
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43. Integrin [[alpha].sub.2][[beta].sub.1] mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLC[gamma]2

Author

Inoue, Osamu, Suzuki-Inoue, Katsue, Dean, William L., Frampton, Jon, and Watson, Steve P.

Subjects
Cytology -- Research, Collagen -- Physiological aspects, Collagen -- Genetic aspects, Hemostasis -- Physiological aspects, Hemostasis -- Genetic aspects, Cell adhesion -- Genetic aspects, Cell adhesion -- Physiological aspects, Glycoproteins -- Genetic aspects, Glycoproteins -- Physiological aspects, Tyrosine -- Physiological aspects, Tyrosine -- Genetic aspects, Biological sciences
Abstract

Collagen plays a critical role in hemostasis by promoting adhesion and activation of platelets at sites of vessel injury. In the present model of platelet--collagen interaction, adhesion is mediated via the inside-out regulation of integrin [[alpha].sub.2][[beta].sub.1] and activation through the glycoprotein VI (GPVI)--Fc receptor (FcR) [gamma]-chain complex. The present study extends this model by demonstrating that engagement of [[alpha].sub.2][[beta].sub.1] by an integrin-specific sequence from within collagen or by collagen itself generates tyrosine kinase--based intracellular signals that lead to formation of filopodia and lamellipodia in the absence of the GPVI-FcR [gamma]-chain complex. The same events do not occur in platelet suspensions. [[alpha].sub.2][[beta].sub.1] activation of adherent platelets stimulates tyrosine phosphorylation of many of the proteins in the GPVI-FcR [gamma]-chain cascade, including Src, Syk, SLP-76, and PLC[gamma]2 as well as plasma membrane calcium ATPase and focal adhesion kinase. [[alpha].sub.2][[beta].sub.1]-mediated spreading is dramatically inhibited in the presence of the Src kinase inhibitor PP2 and in PLC[gamma]2-deficient platelets. Spreading is abolished by chelation of intracellular [Ca.sup.2+]. Demonstration that adhesion of platelets to collagen via [[alpha].sub.2][[beta].sub.1] generates intracellular signals provides a new insight into the mechanisms that control thrombus formation and may explain the unstable nature of [[beta].sub.1]-deficient thrombi and why loss of the GPVI-FcR [gamma]-chain complex has a relatively minor effect on bleeding.

Published
2003

49. Molecular epidemiology of the attachment glycoprotein (G) gene in respiratory syncytial virus in children with acute respiratory infection in Japan in 2009/2010

Author

Yoshida, Ayako, Kiyota, Naoko, Kobayashi, Miho, Nishimura, Koichi, Tsutsui, Rika, Tsukagoshi, Hiroyuki, Hirano, Eiko, Yamamoto, Norio, Ryo, Akihide, Saitoh, Mika, Harada, Seiya, Inoue, Osamu, Kozawa, Kunihisa, Tanaka, Ryota, Noda, Masahiro, Okabe, Nobuhiko, Tashiro, Masato, Mizuta, Katsumi, and Kimura, Hirokazu

Published
2012
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