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967 results on '"Huikuri, Heikki V."'

5. Risk of sudden cardiac death associated with QRS, QTc, and JTc intervals in the general population

Author

Tikkanen, Jani T., Kentta, Tuomas, Porthan, Kimmo, Anttonen, Olli, Eranti, Antti, Aro, Aapo L., Kerola, Tuomas, Rissanen, Harri A., Knekt, Paul, Heliövaara, Markku, Holkeri, Arttu, Haukilahti, Anette, Niiranen, Teemu, Hernesniemi, Jussi, Jula, Antti, Nieminen, Markku S., Myerburg, Robert J., Albert, Christine M., Salomaa, Veikko, Huikuri, Heikki V., and Junttila, M. Juhani

Published
2022
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7. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Author

Young, William J., Lahrouchi, Najim, Isaacs, Aaron, Duong, ThuyVy, Foco, Luisa, Ahmed, Farah, Brody, Jennifer A., Salman, Reem, Noordam, Raymond, Benjamins, Jan-Walter, Haessler, Jeffrey, Lyytikäinen, Leo-Pekka, Repetto, Linda, Concas, Maria Pina, van den Berg, Marten E., Weiss, Stefan, Baldassari, Antoine R., Bartz, Traci M., Cook, James P., Evans, Daniel S., Freudling, Rebecca, Hines, Oliver, Isaksen, Jonas L., Lin, Honghuang, Mei, Hao, Moscati, Arden, Müller-Nurasyid, Martina, Nursyifa, Casia, Qian, Yong, Richmond, Anne, Roselli, Carolina, Ryan, Kathleen A., Tarazona-Santos, Eduardo, Thériault, Sébastien, van Duijvenboden, Stefan, Warren, Helen R., Yao, Jie, Raza, Dania, Aeschbacher, Stefanie, Ahlberg, Gustav, Alonso, Alvaro, Andreasen, Laura, Bis, Joshua C., Boerwinkle, Eric, Campbell, Archie, Catamo, Eulalia, Cocca, Massimiliano, Cutler, Michael J., Darbar, Dawood, De Grandi, Alessandro, De Luca, Antonio, Ding, Jun, Ellervik, Christina, Ellinor, Patrick T., Felix, Stephan B., Froguel, Philippe, Fuchsberger, Christian, Gögele, Martin, Graff, Claus, Graff, Mariaelisa, Guo, Xiuqing, Hansen, Torben, Heckbert, Susan R., Huang, Paul L., Huikuri, Heikki V., Hutri-Kähönen, Nina, Ikram, M. Arfan, Jackson, Rebecca D., Junttila, Juhani, Kavousi, Maryam, Kors, Jan A., Leal, Thiago P., Lemaitre, Rozenn N., Lin, Henry J., Lind, Lars, Linneberg, Allan, Liu, Simin, MacFarlane, Peter W., Mangino, Massimo, Meitinger, Thomas, Mezzavilla, Massimo, Mishra, Pashupati P., Mitchell, Rebecca N., Mononen, Nina, Montasser, May E., Morrison, Alanna C., Nauck, Matthias, Nauffal, Victor, Navarro, Pau, Nikus, Kjell, Pare, Guillaume, Patton, Kristen K., Pelliccione, Giulia, Pittman, Alan, Porteous, David J., Pramstaller, Peter P., Preuss, Michael H., Raitakari, Olli T., Reiner, Alexander P., Ribeiro, Antonio Luiz P., Rice, Kenneth M., Risch, Lorenz, Schlessinger, David, Schotten, Ulrich, Schurmann, Claudia, Shen, Xia, Shoemaker, M. Benjamin, Sinagra, Gianfranco, Sinner, Moritz F., Soliman, Elsayed Z., Stoll, Monika, Strauch, Konstantin, Tarasov, Kirill, Taylor, Kent D., Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Weng, Lu-Chen, Whitsel, Eric A., Wilson, James G., Avery, Christy L., Conen, David, Correa, Adolfo, Cucca, Francesco, Dörr, Marcus, Gharib, Sina A., Girotto, Giorgia, Grarup, Niels, Hayward, Caroline, Jamshidi, Yalda, Järvelin, Marjo-Riitta, Jukema, J. Wouter, Kääb, Stefan, Kähönen, Mika, Kanters, Jørgen K., Kooperberg, Charles, Lehtimäki, Terho, Lima-Costa, Maria Fernanda, Liu, Yongmei, Loos, Ruth J. F., Lubitz, Steven A., Mook-Kanamori, Dennis O., Morris, Andrew P., O’Connell, Jeffrey R., Olesen, Morten Salling, Orini, Michele, Padmanabhan, Sandosh, Pattaro, Cristian, Peters, Annette, Psaty, Bruce M., Rotter, Jerome I., Stricker, Bruno, van der Harst, Pim, van Duijn, Cornelia M., Verweij, Niek, Wilson, James F., Arking, Dan E., Ramirez, Julia, Lambiase, Pier D., Sotoodehnia, Nona, Mifsud, Borbala, Newton-Cheh, Christopher, and Munroe, Patricia B.

Published
2022
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9. Reproducibility of autonomic cardiovascular function and hemodynamics at rest and during recovery from exercise.

Author

Ylinen, Venla P., Valtonen, Rasmus I. P., Junttila, M. Juhani, Kerkelä, Risto, Huikuri, Heikki V., and Tulppo, Mikko P.

Subjects
AEROBIC exercises, HEART beat, HEMODYNAMICS, EXERCISE therapy, BLOOD pressure, BLOOD pressure testing machines, AMBULATORY blood pressure monitoring
Abstract

Smartwatches and home‐based blood pressure (BP) devices have permitted easy use of heart rate variability (HRV) and BP to identify the recovery status of users after acute exercise training. The reproducibility of HRV and BP after exercise in healthy young participants is not well known. Eighteen participants (age 27 ± 6 years, female n = 8) performed test and retest aerobic exercises (cycling, 30 min, 60% of peak workload, W) and a control session in randomized order. RMSSD, high and low‐frequency power of RR intervals, and BP were measured at rest and 30–60 min after interventions. The relative reproducibility was assessed by the intraclass correlation coefficient (ICC) and 95% confidence interval (95% CI). The absolute reproducibility was evaluated using the coefficient of variation (CV%). HRV indices revealed moderate‐to‐excellent reproducibility at rest (ICC 0.81–0.86; 95% CI 0.53–0.95) but not after exercise (ICC −0.06 to 0.60; 95% CI −1.85 to 0.85). Systolic BP had a good‐to‐excellent reproducibility before (ICC 0.93; 95% CI 0.81–0.98, CV% 4.2) and after exercise (ICC 0.93; 95% CI 0.81–0.97, CV% 4.2). The reproducibility of HRV indices is poor after exercise in young participants. However, the reproducibility of BP is excellent at rest and after aerobic exercise. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Nocturnal respiratory rate predicts ICD benefit: A prospective, controlled, multicentre cohort study

Author

Dommasch, Michael, Steger, Alexander, Barthel, Petra, Huster, Katharina M, Müller, Alexander, Sinnecker, Daniel, Laugwitz, Karl-Ludwig, Penzel, Thomas, Lubinski, Andrzej, Flevari, Panagiota, Harden, Markus, Friede, Tim, Kääb, Stefan, Merkely, Bela, Sticherling, Christian, Willems, Rik, Huikuri, Heikki V., Bauer, Axel, Malik, Marek, Zabel, Markus, and Schmidt, Georg

Published
2021
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12. Automated electrocardiographic quantification of myocardial scar in patients undergoing primary prevention implantable cardioverter-defibrillator implantation: Association with mortality and subsequent appropriate and inappropriate therapies

Author

Reichlin, Tobias, Asatryan, Babken, Vos, Marc A., Willems, Rik, Huikuri, Heikki V., Junttila, M. Juhani, Schlögl, Simon C., Hnatkova, Katerina, Schaer, Beat A., Malik, Marek, Zabel, Markus, and Sticherling, Christian

Published
2020
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22. Common variation in fatty acid metabolic genes and risk of incident sudden cardiac arrest

Author

Lemaitre, Rozenn N, Johnson, Catherine O, Hesselson, Stephanie, Sotoodhenia, Nona, McKnight, Barbara, Sitlani, Colleen M, Rea, Thomas D, King, Irena B, Kwok, Pui-Yan, Mak, Angel, Li, Guo, Brody, Jennifer, Larson, Eric, Mozaffarian, Dariush, Psaty, Bruce M, Huertas-Vazquez, Adriana, Tardif, Jean-Claude, Albert, Christine M, Lyytikäinen, Leo-Pekka, Arking, Dan E, Kääb, Stefan, Huikuri, Heikki V, Krijthe, Bouwe P, Eijgelsheim, Mark, Wang, Ying A, Reinier, Kyndaron, Lehtimäki, Terho, Pulit, Sara L, Brugada, Ramon, Müller-Nurasyid, Martina, Newton-Cheh, Chris H, Karhunen, Pekka J, Stricker, Bruno H, Goyette, Philippe, Rotter, Jerome I, Chugh, Sumeet S, Chakravarti, Aravinda, Jouven, Xavier, and Siscovick, David S

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Research, Prevention, Genetics, Aetiology, 2.1 Biological and endogenous factors, 1-Acylglycerophosphocholine O-Acyltransferase, Aged, Algorithms, Alleles, Case-Control Studies, Death, Sudden, Cardiac, Fatty Acids, Female, Genetic Predisposition to Disease, Genetic Variation, Genotype, Humans, Male, Polymorphism, Single Nucleotide, Risk Factors, Death, Sudden, Genetic epidemiology, Biomedical Engineering, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundThere is limited information on genetic factors associated with sudden cardiac arrest (SCA).ObjectiveTo assess the association of common variation in genes in fatty acid pathways with SCA risk.MethodsWe selected 85 candidate genes and 1155 single nucleotide polymorphisms (SNPs) tagging common variation in each gene. We investigated the SNP associations with SCA in a population-based case-control study. Cases (n = 2160) were from a repository of SCA in the greater Seattle area. Controls (n = 2615), frequency-matched on age and sex, were from the same area. We used linear logistic regression to examine SNP associations with SCA. We performed permutation-based p-min tests to account for multiple comparisons within each gene. The SNP associations with a corrected P value of

Published
2014

24. QRS complex and T wave planarity for the efficacy prediction of automatic implantable defibrillators.

Author

Hnatkova, Katerina, Andršová, Irena, Novotný, Tomáš, Vanderberk, Bert, Sprenkeler, David, Junttila, Juhani, Reichlin, Tobias, Schlögl, Simon, Vos, Marc A., Friede, Tim, Bauer, Axel, Huikuri, Heikki V., Willems, Rik, Schmidt, Georg, Sticherling, Christian, Zabel, Markus, and Malik, Marek

Subjects
IMPLANTABLE cardioverter-defibrillators, HEART failure, CARDIAC pacing
Published
2024
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29. Lower hemoglobin levels associate with higher baroreflex sensitivity and heart rate variability.

Author

Tapio, Joona, Kiviniemi, Antti M., Perkiömäki, Juha, Junttila, M. Juhani, Huikuri, Heikki V., Ukkola, Olavi, Koivunen, Peppi, and Tulppo, Mikko P.

Abstract

The aim of this study was to cross-sectionally examine whether hemoglobin (Hb) levels within the normal variation associate with heart rate variability (HRV) measures and baroreflex sensitivity (BRS). The study population included 733 Finnish subjects of the OPERA cohort (aged 41-59 yr, 53% males, 51.7% treated for hypertension) of whom HRV was measured from a standardized 45-min period and whose Hb levels were within the Finnish reference intervals. The low Hb tertile (mean Hb, 135 g/L) had an overall healthier metabolic profile compared with the high Hb tertile (mean Hb, 152 g/L). BRS was higher in the low Hb tertile compared with the high Hb tertile (P < 0.05). R-R interval (RRi) and standard deviation (SD) of the RRi (SDNN)index were the longest in the low Hb tertile regardless of posture. Of the spectral components of HRV, HF power was the highest in the low Hb tertile regardless of posture (P < 0.05). In a stepwise logistic regression model, BRS associated negatively with Hb levels after adjusting for covariates (B = -0.160 [-0.285; -0.035]). Similar associations were observed for SDNNindex when lying down (B = -0.105 [-0.207; -0.003]) and walking (B = -0.154 [-0.224; -0.083]). For HF power negative associations with Hb levels were observed when lying down (B = -0.110 [-0.180; -0.040]), sitting (B = -0.150 [-0.221; -0.079]), and in total analysis (B = -0.124 [-0.196; -0.053]). Overall, lower Hb levels associated independently with healthier cardiac autonomic function. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Repolarization Heterogeneity Measured With T-Wave Area Dispersion in Standard 12-Lead ECG Predicts Sudden Cardiac Death in General Population

Author

Kenttä, Tuomas V., Sinner, Moritz F., Nearing, Bruce D., Freudling, Rebecca, Porthan, Kimmo, Tikkanen, Jani T., Müller-Nurasyid, Martina, Schramm, Katharina, Viitasalo, Matti, Jula, Antti, Nieminen, Markku S., Peters, Annette, Salomaa, Veikko, Oikarinen, Lasse, Verrier, Richard L., Kääb, Stefan, Junttila, M. Juhani, and Huikuri, Heikki V.

Published
2018
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46. Causes and characteristics of unexpected sudden cardiac death in octogenarians/nonagenarians.

Author

Puolitaival, Elisa, Vähätalo, Juha, Holmström, Lauri, Haukilahti, M. Anette E., Pakanen, Lasse, Ukkola, Olavi H., Junttila, M. Juhani, Huikuri, Heikki V., and Perkiömäki, Juha S.

Subjects
CARDIAC arrest, AUTOPSY, OCTOGENARIANS, NONAGENARIANS, IMPLANTABLE cardioverter-defibrillators, HEART, MYOCARDIAL ischemia, CORONARY disease
Abstract

Introduction: The risk for sudden cardiac death (SCD) increases with ageing. Methods: We evaluated causes and characteristics of unexpected SCD in SCD victims aged ≥ 80 years in a consecutive series of 5,869 SCD victims in Northern Finland. All the victims underwent medico-legal autopsy as medico-legal autopsy is mandatory in cases of unexpected sudden death in Finland. All the non-cardiac deaths such as pulmonary embolism and cerebral hemorrhage were excluded from the study, as were unnatural deaths such as intoxications. Results: Among SCD victims ≥ 80 years, 91.0% of SCDs were due to ischemic heart disease (IHD) determined in autopsy and 9.0% due to non-ischemic heart disease (NIHD), whereas among those < 80 years, only 72.6% of SCDs were due to IHD and 27.4% due to NIHD (P <.001). Severe fibrosis in myocardium was more common whereas heart weight and liver weight, body mass index and abdominal fat thickness, were lower among SCD victims aged ≥ 80 years than among victims aged < 80 years. In those with IHD as etiology of SCD, at least 75% stenosis in one or more major coronary vessels was more common in SCD victims aged ≥ 80 years than among victims aged < 80 years (P =.001). SCD victims 80 years or older were less likely to die during physical activity than those under 80 years old (5.6% vs. 15.9%, P <.001). Dying in sauna was more common among those ≥ 80 years than among those < 80 years (5.5% vs. 2.6%, P <.001). Conclusion: In victims of unexpected SCD aged ≥ 80 years, the autopsy-based etiology of SCD was more commonly IHD than in those aged < 80 years. In SCD victims aged ≥ 80 years, severe fibrosis in myocardium, representing arrhythmic substrate, was more common than in the younger ones. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Association of electrocardiographic spatial heterogeneity of repolarization and spatial heterogeneity of atrial depolarization with left ventricular fibrosis.

Author

Hekkanen, Jenni J, Kenttä, Tuomas V, Holmström, Lauri, Tulppo, Mikko P, Ukkola, Olavi H, Pakanen, Lasse, Junttila, M Juhani, Huikuri, Heikki V, and Perkiömäki, Juha S

Abstract

Aims To evaluate the relationship between spatial heterogeneity of electrocardiographic repolarization and spatial heterogeneity of atrial depolarization with arrhythmic substrate represented by left ventricular fibrosis. Methods and results We assessed the associations of T- and P-wave morphology parameters analysed from the standard 12-lead electrocardiograms with left ventricular fibrosis in 378 victims of unexpected sudden cardiac death (SCD) who underwent medico-legal autopsy. Based on autopsy findings, the SCD victims were categorized into four different groups according to different stages of severity of left ventricular fibrosis (substantial fibrosis, moderate patchy fibrosis, scattered mild fibrosis, no fibrosis). T-wave and P-wave area dispersion (TWAd: 0.0841 ± 0.496, 0.170 ± 0.492, 0.302 ± 404, 0.296 ± 0.476, P = 0.008; PWAd: 0.574 ± 0.384, 0.561 ± 0.367, 0.654 ± 0.281, 0.717 ± 0.257, P = 0.011, respectively; low values abnormal), non-dipolar components of T-wave and P-wave morphology (T_NonDipolarABS: 0.0496 ± 0.0377, 0.0571 ± 0.0487, 0.0432 ± 0.0476, 0.0380 ± 0.0377, P = 0.027; P_NonDipolarABS: 0.0132 ± 0.0164, 0.0130 ± 0.0135, 0.0092 ± 0.0117, 0.0069 ± 0.00472, P = 0.005, respectively, high values abnormal), T-wave morphology dispersion (TMD: 45.9 ± 28.3, 40.5 ± 25.8, 35.5 ± 24.9, 33.0 ± 24.6, P = 0.030, respectively, high values abnormal), and P-wave heterogeneity (PWH: 20.0 ± 9.44, 19.7 ± 8.87, 17.9 ± 9.78, 15.4 ± 4.60, P = 0.019, respectively, high values abnormal) differed significantly between the groups with different stages of left ventricular fibrosis. After adjustment with heart weight, T_NonDipolarABS [standardized β (sβ) = 0.131, P = 0.014], PWAd (sβ = −0.161, P = 0.003), P_NonDipolarABS (sβ = 0.174, P = 0.001), and PWH (sβ = 0.128, P = 0.015) retained independent association, and TWAd (sβ = −0.091, P = 0.074) and TMD (sβ = 0.097, P = 0.063) tended to retain their association with the degree of myocardial fibrosis. Conclusion Our findings suggest that abnormal values of T- and P-wave morphology are associated with arrhythmic substrate represented by ventricular fibrosis partly explaining the mechanism behind their prognostic significance. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Use of Psychotropic Medication in Victims of Sudden Cardiac Death with Nonischemic Heart Disease.

Author

Kauppila, Janna P., Pakanen, Lasse, Porvari, Katja, Vähätalo, Juha, Holmström, Lauri, Haukilahti, M. Anette E., Perkiömäki, Juha, Huikuri, Heikki V., and Junttila, M. Juhani

Subjects
CARDIAC arrest, PSYCHIATRIC drugs, HEART diseases, CORONARY artery disease, VICTIMS
Abstract

Background: Nonischemic heart disease (NIHD) is the underlying pathology in about 20% of sudden cardiac deaths (SCDs). Psychotropic medication has been reported as a risk factor for SCD among patients with coronary artery disease, but similar information concerning NIHD is scarce. Objectives: We evaluated the use of psychotropic medication in victims of SCD due to NIHD and compared it to the general medication use in Finland. Method: Study population was derived from the Finnish Genetic Study of Arrhythmic Events (Fingesture) (n = 5,869, mean age: 65 ± 12, 79% males; 1,404 victims of SCD due to NIHD, mean age: 57 ± 13, 77% males). All deaths occurred in Northern Finland during 1998–2017. All victims underwent a medicolegal autopsy. Data on use of medication were defined using postmortem toxicology results and patient records. Subjects with neither toxicological analysis nor information of medication use available were excluded. Information on general medication use was derived from Finnish Statistics on Medicines 2018 and presented as defined daily dose/1,000 inhabitants/day. Results: Psychotropic medication was used by 579 (41%) subjects with NIHD, whereas in the general population, only 12% were estimated to use psychotropics. The results were similar in subgroups of psychotropic medication: 27% versus 2.3% for benzodiazepines, 19% versus 7.5% for antidepressants, and 18% versus 2.2% for antipsychotics. Conclusions: Use of psychotropic medication is common in victims of SCD due to NIHD compared to the general population. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Prognostic value of P-wave morphology in general population.

Author

Laitinen, Idamaria, Kenttä, Tuomas V, Passi, Jussi, Haukilahti, Mira Anette E, Eranti, Antti, Holkeri, Arttu, Aro, Aapo L, Kerola, Tuomas, Noponen, Kai, Seppänen, Tapio, Rissanen, Harri, Knekt, Paul, Heliövaara, Markku, Ukkola, Olavi H, Junttila, M Juhani, Huikuri, Heikki V, and Perkiömäki, Juha S

Abstract

Aims To evaluate the prognostic significance of novel P-wave morphology descriptors in general population. Methods and results Novel P-wave morphology variables were analyzed from orthogonal X-, Y-, Z-leads of the digitized electrocardiogram using a custom-made software in 6906 middle-aged subjects of the Mini-Finland Health Survey. A total of 3747 (54.3%) participants died during the follow-up period of 24.3 ± 10.4 years; 379 (5.5%) of the study population succumbed to sudden cardiac death (SCD), 928 (13.4%) to non-SCD (NSCD) and 2440 (35.3%) patients to non-cardiac death (NCD). In univariate comparisons, most of the studied P-wave morphology parameters had a significant association with all modes of death (P from <0.05 to <0.001). After relevant adjustments in the Cox multivariate hazards model, P-wave morphology dispersion (PMD) still tended to predict SCD [hazard ratio (HR): 1.006, 95% confidence interval (CI): 1.000–1.012, P = 0.05) but not NSCD (HR: 0.999, 95% CI: 0.995–1.003, P = 0.68) or NCD (HR: 0.999, 95% CI: 0.997–1.001, P = 0.44). The P-wave maximum amplitude in the lead Z (P-MaxAmp-Z) predicted SCD even after multivariate adjustments (HR: 1.010, 95% CI: 1.005–1.015, P = 0.0002) but also NSCD (HR: 1.005, 95% CI: 1.002–1.009, P = 0.0005) and NCD (HR: 1.002, 95% CI: 1.000–1.005, P = 0.03). Conclusion Abnormalities of P-wave morphology are associated with the risk of all modes of death in general population. After relevant adjustments, PMD was still closely associated with the risk of SCD but not with NSCD or NCD. P-MaxAmp-Z predicted SCD even after adjustments, however, it also retained its association with NSCD and NCD. [ABSTRACT FROM AUTHOR]

Published
2023
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