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This paper investigates the long-term effects of institutions of higher education (IHEs) on regional economic growth with an application of spatial econometrics. IHEs are classified based on the fields of programs offered and degree-granting activities. I use county-level data for the contiguous US to estimate the marginal effects of IHEs on the changes in log employment and log wages in own counties and neighboring counties between 1970 and 2000. Evidence is found of knowledge spillovers of IHEs, especially for cross-county spillovers. Counties withmore IHEs on location or in their neighboring counties experienced modestly faster employment growth over the 30-year period. Institutions offering accredited business programs had much larger effects than the others. With respect to degree-granting activities, only those institutions awarding bachelor's degrees or above had significant growth-boosting effects. When industrial mix of counties is controlled for, own-county effects diminish except for business programs, whereas all neighboring-county effects prevail. [ABSTRACT FROM AUTHOR]