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923 results on '"Hoffmann, Markus"'

1. Spermidine is essential for fasting-mediated autophagy and longevity

Author

Hofer, Sebastian J., Daskalaki, Ioanna, Bergmann, Martina, Friščić, Jasna, Zimmermann, Andreas, Mueller, Melanie I., Abdellatif, Mahmoud, Nicastro, Raffaele, Masser, Sarah, Durand, Sylvère, Nartey, Alexander, Waltenstorfer, Mara, Enzenhofer, Sarah, Faimann, Isabella, Gschiel, Verena, Bajaj, Thomas, Niemeyer, Christine, Gkikas, Ilias, Pein, Lukas, Cerrato, Giulia, Pan, Hui, Liang, YongTian, Tadic, Jelena, Jerkovic, Andrea, Aprahamian, Fanny, Robbins, Christine E., Nirmalathasan, Nitharsshini, Habisch, Hansjörg, Annerer, Elisabeth, Dethloff, Frederik, Stumpe, Michael, Grundler, Franziska, Wilhelmi de Toledo, Françoise, Heinz, Daniel E., Koppold, Daniela A., Rajput Khokhar, Anika, Michalsen, Andreas, Tripolt, Norbert J., Sourij, Harald, Pieber, Thomas R., de Cabo, Rafael, McCormick, Mark A., Magnes, Christoph, Kepp, Oliver, Dengjel, Joern, Sigrist, Stephan J., Gassen, Nils C., Sedej, Simon, Madl, Tobias, De Virgilio, Claudio, Stelzl, Ulrich, Hoffmann, Markus H., Eisenberg, Tobias, Tavernarakis, Nektarios, Kroemer, Guido, and Madeo, Frank

Published
2024
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3. Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens

Author

Groß, Rüdiger, Reßin, Hanna, von Maltitz, Pascal, Albers, Dan, Schneider, Laura, Bley, Hanna, Hoffmann, Markus, Cortese, Mirko, Gupta, Dhanu, Deniz, Miriam, Choi, Jae-Yeon, Jansen, Jenny, Preußer, Christian, Seehafer, Kai, Pöhlmann, Stefan, Voelker, Dennis R., Goffinet, Christine, Pogge-von Strandmann, Elke, Bunz, Uwe, Bartenschlager, Ralf, El Andaloussi, Samir, Sparrer, Konstantin M. J., Herker, Eva, Becker, Stephan, Kirchhoff, Frank, Münch, Jan, and Müller, Janis A.

Published
2024
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4. Overcoming leakage in quantum error correction

Author

Miao, Kevin C., McEwen, Matt, Atalaya, Juan, Kafri, Dvir, Pryadko, Leonid P., Bengtsson, Andreas, Opremcak, Alex, Satzinger, Kevin J., Chen, Zijun, Klimov, Paul V., Quintana, Chris, Acharya, Rajeev, Anderson, Kyle, Ansmann, Markus, Arute, Frank, Arya, Kunal, Asfaw, Abraham, Bardin, Joseph C., Bourassa, Alexandre, Bovaird, Jenna, Brill, Leon, Buckley, Bob B., Buell, David A., Burger, Tim, Burkett, Brian, Bushnell, Nicholas, Campero, Juan, Chiaro, Ben, Collins, Roberto, Conner, Paul, Crook, Alexander L., Curtin, Ben, Debroy, Dripto M., Demura, Sean, Dunsworth, Andrew, Erickson, Catherine, Fatemi, Reza, Ferreira, Vinicius S., Burgos, Leslie Flores, Forati, Ebrahim, Fowler, Austin G., Foxen, Brooks, Garcia, Gonzalo, Giang, William, Gidney, Craig, Giustina, Marissa, Gosula, Raja, Dau, Alejandro Grajales, Gross, Jonathan A., Hamilton, Michael C., Harrington, Sean D., Heu, Paula, Hilton, Jeremy, Hoffmann, Markus R., Hong, Sabrina, Huang, Trent, Huff, Ashley, Iveland, Justin, Jeffrey, Evan, Jiang, Zhang, Jones, Cody, Kelly, Julian, Kim, Seon, Kostritsa, Fedor, Kreikebaum, John Mark, Landhuis, David, Laptev, Pavel, Laws, Lily, Lee, Kenny, Lester, Brian J., Lill, Alexander T., Liu, Wayne, Locharla, Aditya, Lucero, Erik, Martin, Steven, Megrant, Anthony, Mi, Xiao, Montazeri, Shirin, Morvan, Alexis, Naaman, Ofer, Neeley, Matthew, Neill, Charles, Nersisyan, Ani, Newman, Michael, Ng, Jiun How, Nguyen, Anthony, Nguyen, Murray, Potter, Rebecca, Rocque, Charles, Roushan, Pedram, Sankaragomathi, Kannan, Schurkus, Henry F., Schuster, Christopher, Shearn, Michael J., Shorter, Aaron, Shutty, Noah, Shvarts, Vladimir, Skruzny, Jindra, Smith, W. Clarke, Sterling, George, Szalay, Marco, Thor, Douglas, Torres, Alfredo, White, Theodore, Woo, Bryan W. K., Yao, Z. Jamie, Yeh, Ping, Yoo, Juhwan, Young, Grayson, Zalcman, Adam, Zhu, Ningfeng, Zobrist, Nicholas, Neven, Hartmut, Smelyanskiy, Vadim, Petukhov, Andre, Korotkov, Alexander N., Sank, Daniel, and Chen, Yu

Published
2023
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5. TNM 8 staging system beyond p16: Double HPV/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma

Author

von Buchwald, Christian, Jakobsen, Kathrine Kronberg, Carlander, Amanda-Louise Fenger, Tous, Sara, Grønhøj, Christian, Rasmussen, Jacob H., Brooks, Jill, Taberna, Miren, Mena, Marisa, Morey, Francisca, Bruni, Laia, Batis, Nikolaos, Brakenhoff, Ruud H., René Leemans, C., Jong, Robert J.Baatenburg de, Klussmann, Jens Peter, Wuerdemann, Nora, Wagner, Steffen, Dalianis, Tina, Marklund, Linda, Mirghani, Haïtham, Schache, Andrew, James, Jaqueline A., Huang, Shao Hui, O’Sullivan, Brian, Nankivell, Paul, Broglie, Martina A., Hoffmann, Markus, Quabius, Elgar Susanne, Anderson, Lesley A., Craig, Stephanie G., Alemany, Laia, and Mehanna, Hisham

Published
2024
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11. Omicron subvariant BA.5 efficiently infects lung cells

Author

Hoffmann, Markus, Wong, Lok-Yin Roy, Arora, Prerna, Zhang, Lu, Rocha, Cheila, Odle, Abby, Nehlmeier, Inga, Kempf, Amy, Richter, Anja, Halwe, Nico Joel, Schön, Jacob, Ulrich, Lorenz, Hoffmann, Donata, Beer, Martin, Drosten, Christian, Perlman, Stanley, and Pöhlmann, Stefan

Published
2023
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16. Spanning Fermi arcs in a two-dimensional magnet

Author

Chen, Ying-Jiun, Hanke, Jan-Philipp, Hoffmann, Markus, Bihlmayer, Gustav, Mokrousov, Yuriy, Blügel, Stefan, Schneider, Claus M, and Tusche, Christian

Subjects
Quantum Physics, Physical Sciences, Condensed Matter Physics
Abstract

The discovery of topological states of matter has led to a revolution in materials research. When external or intrinsic parameters break symmetries, global properties of topological materials change drastically. A paramount example is the emergence of Weyl nodes under broken inversion symmetry. While a rich variety of non-trivial quantum phases could in principle also originate from broken time-reversal symmetry, realizing systems that combine magnetism with complex topological properties is remarkably elusive. Here, we demonstrate that giant open Fermi arcs are created at the surface of ultrathin hybrid magnets where the Fermi-surface topology is substantially modified by hybridization with a heavy-metal substrate. The interplay between magnetism and topology allows us to control the shape and the location of the Fermi arcs by tuning the magnetization direction. The hybridization points in the Fermi surface can be attributed to a non-trivial mixed topology and induce hot-spots in the Berry curvature, dominating spin and charge transport as well as magneto-electric coupling effects.

Published
2022

17. A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells

Author

Mahoney, Matthew, Damalanka, Vishnu C, Tartell, Michael A, Chung, Dong hee, Lourenço, André Luiz, Pwee, Dustin, Bridwell, Anne E Mayer, Hoffmann, Markus, Voss, Jorine, Karmakar, Partha, Azouz, Nurit P, Klingler, Andrea M, Rothlauf, Paul W, Thompson, Cassandra E, Lee, Melody, Klampfer, Lidija, Stallings, Christina L, Rothenberg, Marc E, Pöhlmann, Stefan, Whelan, Sean PJ, O’Donoghue, Anthony J, Craik, Charles S, and Janetka, James W

Subjects
Biological Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biodefense, Pneumonia, Vaccine Related, Infectious Diseases, Emerging Infectious Diseases, Prevention, Lung, Pneumonia & Influenza, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Benzamidines, Benzothiazoles, COVID-19, Cell Line, Drug Design, Epithelial Cells, Esters, Guanidines, Humans, Mice, Middle East Respiratory Syndrome Coronavirus, Oligopeptides, SARS-CoV-2, Serine Endopeptidases, Small Molecule Libraries, Substrate Specificity, Virus Internalization, COVID-19 Drug Treatment, antiviral, protease inhibitor, structure-based drug discovery, PS-SCL
Abstract

The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This protease activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and of other coronaviruses and is essential for viral spread in the lung. Utilizing rational structure-based drug design (SBDD) coupled to substrate specificity screening of TMPRSS2, we have discovered covalent small-molecule ketobenzothiazole (kbt) TMPRSS2 inhibitors which are structurally distinct from and have significantly improved activity over the existing known inhibitors Camostat and Nafamostat. Lead compound MM3122 (4) has an IC50 (half-maximal inhibitory concentration) of 340 pM against recombinant full-length TMPRSS2 protein, an EC50 (half-maximal effective concentration) of 430 pM in blocking host cell entry into Calu-3 human lung epithelial cells of a newly developed VSV-SARS-CoV-2 chimeric virus, and an EC50 of 74 nM in inhibiting cytopathic effects induced by SARS-CoV-2 virus in Calu-3 cells. Further, MM3122 blocks Middle East respiratory syndrome coronavirus (MERS-CoV) cell entry with an EC50 of 870 pM. MM3122 has excellent metabolic stability, safety, and pharmacokinetics in mice, with a half-life of 8.6 h in plasma and 7.5 h in lung tissue, making it suitable for in vivo efficacy evaluation and a promising drug candidate for COVID-19 treatment.

Published
2021

20. Comparison of three indirect methods for verification and validation of reference intervals at eight medical laboratories: a European multicenter study

Author

Meyer Anne, Müller Robert, Hoffmann Markus, Skadberg Øyvind, Ladang Aurélie, Dieplinger Benjamin, Huf Wolfgang, Stankovic Sanja, Kapoula Georgia, and Orth Matthias

Subjects
indirect methods, reference intervals, reference limits, refiner, reflim, truncated maximum likelihood (tml), validation, verification, Medical technology, R855-855.5
Abstract

Indirect methods for the indirect estimation of reference intervals are increasingly being used, especially for validation of reference intervals, as they can be applied to routine patient data. In this study, we compare three statistically different indirect methods for the verification and validation of reference intervals in eight laboratories distributed throughout Europe.

Published
2023
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22. Observation of Hydrogen-Induced Dzyaloshinskii-Moriya Interaction and Reversible Switching of Magnetic Chirality

Author

Chen, Gong, Robertson, MacCallum, Hoffmann, Markus, Ophus, Colin, Cauduro, André L Fernandes, Conte, Roberto Lo, Ding, Haifeng, Wiesendanger, Roland, Blügel, Stefan, Schmid, Andreas K, and Liu, Kai

Subjects
Quantum Physics, Physical Sciences, Condensed Matter Physics, cond-mat.mtrl-sci, cond-mat.mes-hall, Astronomical and Space Sciences, Physical sciences
Abstract

The Dzyaloshinskii-Moriya interaction (DMI) has drawn much attention, as it stabilizes magnetic chirality, with important implications in fundamental and applied research. This antisymmetric exchange interaction is induced by the broken inversion symmetry at interfaces or in noncentrosymmetric lattices. Significant interfacial DMIs are often found at magnetic/heavy-metal interfaces with large spin-orbit coupling. Recent studies have shown promise for induced DMI at interfaces involving light elements such as carbon (graphene) or oxygen. Here, we report direct observation of induced DMI by chemisorption of the lightest element, hydrogen, on a ferromagnetic layer at room temperature, which is supported by density functional theory calculations. We further demonstrate a reversible chirality transition of the magnetic domain walls due to the induced DMI via hydrogen chemisorption and desorption. These results shed new light on the understanding of DMI in low atomic number materials and the design of novel chiral spintronics and magneto-ionic devices.

Published
2021

26. Large Dzyaloshinskii-Moriya interaction induced by chemisorbed oxygen on a ferromagnet surface.

Author

Chen, Gong, Mascaraque, Arantzazu, Jia, Hongying, Zimmermann, Bernd, Robertson, MacCallum, Conte, Roberto Lo, Hoffmann, Markus, González Barrio, Miguel Angel, Ding, Haifeng, Wiesendanger, Roland, Michel, Enrique G, Blügel, Stefan, Schmid, Andreas K, and Liu, Kai

Abstract

The Dzyaloshinskii-Moriya interaction (DMI) is an antisymmetric exchange interaction that stabilizes chiral spin textures. It is induced by inversion symmetry breaking in noncentrosymmetric lattices or at interfaces. Recently, interfacial DMI has been found in magnetic layers adjacent to transition metals due to the spin-orbit coupling and at interfaces with graphene due to the Rashba effect. We report direct observation of strong DMI induced by chemisorption of oxygen on a ferromagnetic layer at room temperature. The sign of this DMI and its unexpectedly large magnitude-despite the low atomic number of oxygen-are derived by examining the oxygen coverage-dependent evolution of magnetic chirality. We find that DMI at the oxygen/ferromagnet interface is comparable to those at ferromagnet/transition metal interfaces; it has enabled direct tailoring of skyrmion's winding number at room temperature via oxygen chemisorption. This result extends the understanding of the DMI, opening up opportunities for the chemisorption-related design of spin-orbitronic devices.

Published
2020

27. Safety and Immunogenicity against Ancestral, Delta and Omicron Virus Variants Following a Booster Dose of an Inactivated Whole-Virus COVID-19 Vaccine (VLA2001): Interim analysis of an open-label extension of the randomized, controlled, phase 3 COV-COMPARE trial

Author

Taucher, Christian, Lazarus, Rajeka, Dellago, Hanna, Maurer, Gabriele, Weisova, Petronela, Corbic-Ramljak, Irena, Dubischar, Katrin, Lilja, Anders, Eder-Lingelbach, Susanne, Hochreiter, Romana, Jaramillo, Juan Carlos, Junker, Helga, Krammer, Michael, Pusic, Petra, Querton, Benedicte, Larcher-Senn, Julian, Hoffmann, Markus, Pöhlmann, Stefan, and Finn, Adam

Published
2023
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33. Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations

Author

Jacobsen, Henning, Strengert, Monika, Maaß, Henrike, Ynga Durand, Mario Alberto, Katzmarzyk, Maeva, Kessel, Barbora, Harries, Manuela, Rand, Ulfert, Abassi, Leila, Kim, Yeonsu, Lüddecke, Tatjana, Metzdorf, Kristin, Hernandez, Pilar, Ortmann, Julia, Heise, Jana-Kristin, Castell, Stefanie, Gornyk, Daniela, Glöckner, Stephan, Melhorn, Vanessa, Kemmling, Yvonne, Lange, Berit, Dulovic, Alex, Marsall, Patrick, Häring, Julia, Junker, Daniel, Schneiderhan-Marra, Nicole, Hoffmann, Markus, Pöhlmann, Stefan, Krause, Gérard, and Cicin-Sain, Luka

Published
2022
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34. BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19

Author

Behrens, Georg M. N., Barros-Martins, Joana, Cossmann, Anne, Ramos, Gema Morillas, Stankov, Metodi V., Odak, Ivan, Dopfer-Jablonka, Alexandra, Hetzel, Laura, Köhler, Miriam, Patzer, Gwendolyn, Binz, Christoph, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Krähling, Verena, Bernhardt, Günter, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Hammerschmidt, Swantje I., and Förster, Reinhold

Published
2022
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36. ACE2-independent sarbecovirus cell entry can be supported by TMPRSS2-related enzymes and can reduce sensitivity to antibody-mediated neutralization.

Author

Zhang, Lu, Cheng, Hsiu-Hsin, Krüger, Nadine, Hörnich, Bojan, Graichen, Luise, Hahn, Alexander S., Schulz, Sebastian R., Jäck, Hans-Martin, Stankov, Metodi V., Behrens, Georg M. N., Müller, Marcel A., Drosten, Christian, Mörer, Onnen, Winkler, Martin Sebastian, Qian, ZhaoHui, Pöhlmann, Stefan, and Hoffmann, Markus

Abstract

The COVID-19 pandemic, caused by SARS-CoV-2, demonstrated that zoonotic transmission of animal sarbecoviruses threatens human health but the determinants of transmission are incompletely understood. Here, we show that most spike (S) proteins of horseshoe bat and Malayan pangolin sarbecoviruses employ ACE2 for entry, with human and raccoon dog ACE2 exhibiting broad receptor activity. The insertion of a multibasic cleavage site into the S proteins increased entry into human lung cells driven by most S proteins tested, suggesting that acquisition of a multibasic cleavage site might increase infectivity of diverse animal sarbecoviruses for the human respiratory tract. In contrast, two bat sarbecovirus S proteins drove cell entry in an ACE2-independent, trypsin-dependent fashion and several ACE2-dependent S proteins could switch to the ACE2-independent entry pathway when exposed to trypsin. Several TMPRSS2-related cellular proteases but not the insertion of a multibasic cleavage site into the S protein allowed for ACE2-independent entry in the absence of trypsin and may support viral spread in the respiratory tract. Finally, the pan-sarbecovirus antibody S2H97 enhanced cell entry driven by two S proteins and this effect was reversed by trypsin while trypsin protected entry driven by a third S protein from neutralization by S2H97. Similarly, plasma from quadruple vaccinated individuals neutralized entry driven by all S proteins studied, and availability of the ACE2-independent, trypsin-dependent pathway reduced neutralization sensitivity. In sum, our study reports a pathway for entry into human cells that is ACE2-independent, can be supported by TMPRSS2-related proteases and may be associated with antibody evasion. Author summary: Bats host a wide range of coronaviruses, including those related to SARS-CoV-1 and SARS-CoV-2 (subgenus Sarbecovirus), but their ability to infect human cells remains poorly understood. Identifying sarbecoviruses with zoonotic potential and understanding the factors controlling their entry into human cells are crucial for risk assessment and antiviral development. In this study, we examined how bat sarbecovirus spike proteins facilitate entry into human cells and identified key host factors involved. Using pseudovirus particles, we show that several bat sarbecovirus spike proteins use human and animal ACE2 receptors for entry. Additionally, we confirm that some spike proteins utilize an ACE2-independent entry pathway requiring trypsin treatment and demonstrate that this process is controlled by the spike protein receptor binding domain. Furthermore, we reveal that a subset of ACE2-using bat sarbecovirus spike proteins can switch to ACE2-independent entry following trypsin exposure and show that certain human type II transmembrane serine proteases can substitute for trypsin, enabling ACE2-independent entry. Finally, we demonstrate that repeated COVID-19 vaccination generates cross-neutralizing activity against bat sarbecoviruses, though ACE2-independent entry reduces neutralization sensitivity. [ABSTRACT FROM AUTHOR]

Published
2024
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38. The road to integrate climate change projections with regional land‐use–biodiversity models.

Author

Cabral, Juliano Sarmento, Mendoza‐Ponce, Alma, da Silva, André Pinto, Oberpriller, Johannes, Mimet, Anne, Kieslinger, Julia, Berger, Thomas, Blechschmidt, Jana, Brönner, Maximilian, Classen, Alice, Fallert, Stefan, Hartig, Florian, Hof, Christian, Hoffmann, Markus, Knoke, Thomas, Krause, Andreas, Lewerentz, Anne, Pohle, Perdita, Raeder, Uta, and Rammig, Anja

Subjects
SPECIES diversity, LAND cover, CLIMATE change, SPATIAL resolution, LAND use
Abstract

Copyright of People & Nature is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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39. Network medicine-based epistasis detection in complex diseases: ready for quantum computing.

Author

Hoffmann, Markus, Poschenrieder, Julian M, Incudini, Massimiliano, Baier, Sylvie, Fritz, Amelie, Maier, Andreas, Hartung, Michael, Hoffmann, Christian, Trummer, Nico, Adamowicz, Klaudia, Picciani, Mario, Scheibling, Evelyn, Harl, Maximilian V, Lesch, Ingmar, Frey, Hunor, Kayser, Simon, Wissenberg, Paul, Schwartz, Leon, Hafner, Leon, and Acharya, Aakriti

Published
2024
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41. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

Author

Kim, Yeonsu, Zheng, Xiaoyan, Eschke, Kathrin, Chaudhry, M. Zeeshan, Bertoglio, Federico, Tomić, Adriana, Krmpotić, Astrid, Hoffmann, Markus, Bar-On, Yotam, Boehme, Julia, Bruder, Dunja, Ebensen, Thomas, Brunotte, Linda, Ludwig, Stephan, Messerle, Martin, Guzman, Carlos, Mandelboim, Ofer, Hust, Michael, Pöhlmann, Stefan, Jonjić, Stipan, and Čičin-Šain, Luka

Published
2022
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42. Patients with COVID-19: in the dark-NETs of neutrophils

Author

Ackermann, Maximilian, Anders, Hans-Joachim, Bilyy, Rostyslav, Bowlin, Gary L., Daniel, Christoph, De Lorenzo, Rebecca, Egeblad, Mikala, Henneck, Timo, Hidalgo, Andrés, Hoffmann, Markus, Hohberger, Bettina, Kanthi, Yogendra, Kaplan, Mariana J., Knight, Jason S., Knopf, Jasmin, Kolaczkowska, Elzbieta, Kubes, Paul, Leppkes, Moritz, Mahajan, Aparna, Manfredi, Angelo A., Maueröder, Christian, Maugeri, Norma, Mitroulis, Ioannis, Muñoz, Luis E., Narasaraju, Teluguakula, Naschberger, Elisabeth, Neeli, Indira, Ng, Lai Guan, Radic, Marko Z., Ritis, Konstantinos, Rovere-Querini, Patrizia, Schapher, Mirco, Schauer, Christine, Simon, Hans-Uwe, Singh, Jeeshan, Skendros, Panagiotis, Stark, Konstantin, Stürzl, Michael, van der Vlag, Johan, Vandenabeele, Peter, Vitkov, Ljubomir, von Köckritz-Blickwede, Maren, Yanginlar, Cansu, Yousefi, Shida, Zarbock, Alexander, Schett, Georg, and Herrmann, Martin

Published
2021
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43. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination

Author

Barros-Martins, Joana, Hammerschmidt, Swantje I., Cossmann, Anne, Odak, Ivan, Stankov, Metodi V., Morillas Ramos, Gema, Dopfer-Jablonka, Alexandra, Heidemann, Annika, Ritter, Christiane, Friedrichsen, Michaela, Schultze-Florey, Christian, Ravens, Inga, Willenzon, Stefanie, Bubke, Anja, Ristenpart, Jasmin, Janssen, Anika, Ssebyatika, George, Bernhardt, Günter, Münch, Jan, Hoffmann, Markus, Pöhlmann, Stefan, Krey, Thomas, Bošnjak, Berislav, Förster, Reinhold, and Behrens, Georg M. N.

Published
2021
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47. Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods

Author

Bošnjak, Berislav, Stein, Saskia Catherina, Willenzon, Stefanie, Cordes, Anne Katrin, Puppe, Wolfram, Bernhardt, Günter, Ravens, Inga, Ritter, Christiane, Schultze-Florey, Christian R., Gödecke, Nina, Martens, Jörg, Kleine-Weber, Hannah, Hoffmann, Markus, Cossmann, Anne, Yilmaz, Mustafa, Pink, Isabelle, Hoeper, Marius M., Behrens, Georg M. N., Pöhlmann, Stefan, Blasczyk, Rainer, Schulz, Thomas F., and Förster, Reinhold

Published
2021
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50. A single-dose MCMV-based vaccine elicits long-lasting immune protection in mice against distinct SARS-CoV-2 variants.

Author

Metzdorf, Kristin, Jacobsen, Henning, Yeonsu Kim, Teixeira Alves, Luiz Gustavo, Kulkarni, Upasana, Eschke, Kathrin, Chaudhry, M. Zeeshan, Hoffmann, Markus, Bertoglio, Federico, Ruschig, Maximilian, Hust, Michael, pBrdovčak, Maja Cokarić, Materljan, Jelena, Šustić, Marko, Krmpotić, Astrid, Jonjić, Stipan, Widera, Marek, Ciesek, Sandra, Pöhlmann, Stefan, and Landthaler, Markus

Subjects
BOOSTER vaccines, SARS-CoV-2, COVID-19 pandemic, SARS-CoV-2 Omicron variant, CELLULAR immunity
Abstract

Current vaccines against COVID-19 elicit immune responses that are overall strong but wane rapidly. As a consequence, the necessary booster shots have contributed to vaccine fatigue. Hence, vaccines that would provide lasting protection against COVID-19 are needed, but are still unavailable. Cytomegaloviruses (CMVs) elicit lasting and uniquely strong immune responses. Used as vaccine vectors, they may be attractive tools that obviate the need for boosters. Therefore, we tested the murine CMV (MCMV) as a vaccine vector against COVID-19 in relevant preclinical models of immunization and challenge. We have previously developed a recombinant MCMV vaccine vector expressing the spike protein of the ancestral SARS-CoV-2 (MCMVS). In this study, we show that the MCMVS elicits a robust and lasting protection in young and aged mice. Notably, spike-specific humoral and cellular immunity was not only maintained but also even increased over a period of at least 6 months. During that time, antibody avidity continuously increased and expanded in breadth, resulting in neutralization of genetically distant variants, like Omicron BA.1. A single dose of MCMVS conferred rapid virus clearance upon challenge. Moreover, MCMVS vaccination controlled two variants of concern (VOCs), the Beta (B.1.135) and the Omicron (BA.1) variants. Thus, CMV vectors provide unique advantages over other vaccine technologies, eliciting broadly reactive and long-lasting immune responses against COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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