273 results on '"Hirose, Tomoyasu"'
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2. Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499
3. A novel aromatic compound from the fungus Synnemellisia sp. FKR-0921
4. New antimalarial fusarochromanone analogs produced by the fungal strain Fusarium sp. FKI-9521
5. A novel 12-membered ring non-antibiotic macrolide EM982 attenuates cytokine production by inhibiting IKKβ and IκBα phosphorylation
6. A novel macrolide–Del-1 axis to regenerate bone in old age
7. A new selective inhibitor for IMP-1 metallo-β-lactamase, 3Z,5E-octa-3,5-diene-1,3,4-tricarboxylic acid-3,4-anhydride
8. Pot-economical synthesis of cyclic depsipeptides using a hydrophobic anchor molecule toward the construction of an unnatural peptide library
9. Afidopyropen, a novel insecticide originating from microbial secondary extracts
10. Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process
11. Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action
12. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction.
13. Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes
14. Synthesis and insecticidal efficacy of pyripyropene derivatives. Part II—Invention of afidopyropen
15. Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae
16. Nanaomycin H: A new nanaomycin analog
17. Suppression of Bone Resorption by Madindoline A, a Novel Nonpeptide Antagonist to gp130
18. Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions’ substituent groups
19. Medermycin Inhibits TNFα-Promoted Inflammatory Reaction in Human Synovial Fibroblasts.
20. Development of a nitrogen-bound hydrophobic auxiliary: application to solid/hydrophobic-tag relay synthesis of calpinactam.
21. An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions
22. Jietacins with potent nematocidal activity; efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D
23. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity
24. Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance
25. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation
26. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
27. Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
28. Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model
29. Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958
30. Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening
31. Wickerols A and B: novel anti-influenza virus diterpenes produced by Trichoderma atroviride FKI-3849
32. Hakuhybotrol, a polyketide produced by Hypomyces pseudocorticiicola, characterized with the assistance of 3D ED/MicroED.
33. Jietacin Derivative Inhibits TNF-α-Mediated Inflammatory Cytokines Production via Suppression of the NF-κB Pathway in Synovial Cells.
34. Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag
35. Chemical Degradation-Inspired Total Synthesis of the Antibiotic Macrodiolide, Luminamicin.
36. Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus FKR-0564.
37. Ivermectin Inhibits HBV Entry into the Nucleus by Suppressing KPNA2.
38. Structure, solubility, and permeability relationships in a diverse middle molecule library
39. Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C
40. Towards the total synthesis of aurodox: Preparation of the key hemiacetal-lactone
41. Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin
42. Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide
43. Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approaches
44. Fungal Secondary Metabolite Exophillic Acid Selectively Inhibits the Entry of Hepatitis B and D Viruses.
45. Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: a practical improvement to a second-generation approach from the first-generation
46. Absolute stereochemistries and total synthesis of (+)/(−)-macrosphelides, potent, orally bioavailable inhibitors of cell–cell adhesion
47. Total Syntheses and Chemical Biology Studies of Hymeglusin and Fusarilactone A, Novel Circumventors of β‐Lactam Drug Resistance in Methicillin‐Resistant Staphylococcus aureus.
48. Stereo- and substituent-enabled divergent synthesis of 5,6-spiroketal analogs of avermectin containing a triazole function
49. Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: construction of a key linear intermediate
50. A second-generation total synthesis of (+)-phorboxazole A
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