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Your search keyword '"Hirawa, Nobuhito"' showing total 282 results
Start Over Author "Hirawa, Nobuhito" Publication Type Academic Journals
282 results on '"Hirawa, Nobuhito"'

4. The status of dialysis patients in Asian countries under COVID-19 disaster as of December 2019–June 2022: Vietnam, Indonesia, and Mongolia

Author

Hyodo, Toru, Hirawa, Nobuhito, Kuragano, Takahiro, Takemoto, Yoshiaki, Pham, Bui Van, Nguyen, Ha Minh, Nguyen, Loc Duc, Vu, Hoa, Le, Giang, Nguyen, Hang, Nguyen, Tung, Phan, An, Widiana, I. Gde Raka, Adiya, Saruultuvshin, Nergui, Mandkhai, Dashmend, Galmunkh, Bayankhuu, Narantungalag, Dorjsuren, Tsatsral, Ulziibayar, Dolzodmaa, Zulpihar, Nurguli, Batbold, Bolorchimeg, Bat-Ochir, Amartuvshin, and Dorj, Chuluuntsetseg

Published
2024
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5. Author Correction: Effectiveness of DialBetesPlus, a self-management support system for diabetic kidney disease: Randomized controlled trial

Author

Waki, Kayo, Nara, Mitsuhiko, Enomoto, Syunpei, Mieno, Makiko, Kanda, Eiichiro, Sankoda, Akiko, Kawai, Yuki, Miyake, Kana, Wakui, Hiromichi, Tsurutani, Yuya, Hirawa, Nobuhito, Yamakawa, Tadashi, Komiya, Shiro, Isogawa, Akihiro, Satoh, Shinobu, Minami, Taichi, Iwamoto, Tamio, Takano, Tatsuro, Terauchi, Yasuo, Tamura, Kouichi, Yamauchi, Toshimasa, Nangaku, Masaomi, Kashihara, Naoki, and Ohe, Kazuhiko

Published
2024
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6. Effectiveness of DialBetesPlus, a self-management support system for diabetic kidney disease: Randomized controlled trial

Author

Waki, Kayo, Nara, Mitsuhiko, Enomoto, Syunpei, Mieno, Makiko, Kanda, Eiichiro, Sankoda, Akiko, Kawai, Yuki, Miyake, Kana, Wakui, Hiromichi, Tsurutani, Yuya, Hirawa, Nobuhito, Yamakawa, Tadashi, Komiya, Shiro, Isogawa, Akihiro, Satoh, Shinobu, Minami, Taichi, Iwamoto, Tamio, Takano, Tatsuro, Terauchi, Yasuo, Tamura, Kouichi, Yamauchi, Toshimasa, Nangaku, Masaomi, Kashihara, Naoki, and Ohe, Kazuhiko

Published
2024
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10. Blunted humoral immune response to the fourth dose of BNT162b2 COVID-19 vaccine in patients undergoing hemodialysis

Author

Kanai, Daisuke, Wakui, Hiromichi, Hanaoka, Masaaki, Haze, Tatsuya, Azushima, Kengo, Shinoda, Satoru, Tsukamoto, Shunichiro, Taguchi, Shinya, Kinguchi, Sho, Kanaoka, Tomohiko, Toya, Yoshiyuki, Hirawa, Nobuhito, Kato, Hideaki, Watanabe, Fumimasa, Hanaoka, Kanako, Mitsuhashi, Hiroshi, Yamaguchi, Satoshi, Ohnishi, Toshimasa, and Tamura, Kouichi

Published
2023
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12. The efficacy and safety of mizoribine for maintenance therapy in patients with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA)-associated vasculitis: the usefulness of serum mizoribine monitoring

Author

Mase, Kaori, Saito, Chie, Usui, Joichi, Arimura, Yoshihiro, Nitta, Kosaku, Wada, Takashi, Makino, Hirofumi, Muso, Eri, Hirawa, Nobuhito, Kobayashi, Masaki, Yumura, Wako, Fujimoto, Shouichi, Nakagawa, Naoki, Ito, Takafumi, Yuzawa, Yukio, Matsuo, Seiichi, and Yamagata, Kunihiro

Published
2022
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13. SARS-CoV-2 spike protein antibody titers 6 months after SARS-CoV-2 mRNA vaccination among patients undergoing hemodialysis in Japan

Author

Kanai, Daisuke, Wakui, Hiromichi, Haze, Tatsuya, Azushima, Kengo, Kinguchi, Sho, Tsukamoto, Shunichiro, Kanaoka, Tomohiko, Urate, Shingo, Toya, Yoshiyuki, Hirawa, Nobuhito, Kato, Hideaki, Watanabe, Fumimasa, Hanaoka, Kanako, Hanaoka, Masaaki, Mitsuhashi, Hiroshi, Yamaguchi, Satoshi, Ohnishi, Toshimasa, and Tamura, Kouichi

Published
2022
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15. Current status of renal replacement therapy in Cambodia and Japanese support activities in developing countries in East and Southeast Asia: a report as of June 2018 from the Non-Western World Countries Symposium at the 63rd Annual Meeting of the Japanese Society for Dialysis Therapy

Author

Hyodo, Toru, Hirawa, Nobuhito, Isaka, Yoshitaka, Nakamoto, Hidetomo, Thim, Pichthida, Phon, Elin, Hy, Chanseila, Chan, Sovandy, Kokubo, Kenichi, Matsubara, Hirokazu, Wakai, Haruki, Yamashita, Akihiro C., and Kawanishi, Hideki

Published
2022
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16. Present status of renal replacement therapy in lower-middle-income Asian countries: Cambodia, Myanmar, Laos, Vietnam, Mongolia, and Bhutan as of June 2019 (before COVID-19), from the interviews of leading doctors in every country: (duplicated English publication from “the special Japanese edition of educational lectures in the 64th annual meeting of the Japanese Society for Dialysis Therapy”)

Author

Hyodo, Toru, Yamashita, Akihiro C., Hirawa, Nobuhito, Isaka, Yoshitaka, Nakamoto, Hidetomo, and Shigematsu, Takashi

Published
2022
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18. Association of aldosterone and blood pressure with the risk for cardiovascular events after treatments in primary aldosteronism

Author

Haze, Tatsuya, Hirawa, Nobuhito, Yano, Yuichiro, Tamura, Kouichi, Kurihara, Isao, Kobayashi, Hiroki, Tsuiki, Mika, Ichijo, Takamasa, Wada, Norio, Katabami, Takuyuki, Yamamoto, Koichi, Oki, Kenji, Inagaki, Nobuya, Okamura, Shintaro, Kai, Tatsuya, Izawa, Shoichiro, Yamada, Masanobu, Chiba, Yoshiro, Tanabe, Akiyo, and Naruse, Mitsuhide

Published
2021
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19. ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.

Author

Kobayashi, Yusuke, Yatsu, Keisuke, Haruna, Aiko, Kawano, Rina, Ozawa, Moe, Haze, Tatsuya, Komiya, Shiro, Suzuki, Shota, Ohki, Yuki, Fujiwara, Akira, Saka, Sanae, Hirawa, Nobuhito, Toya, Yoshiyuki, and Tamura, Kouichi

Abstract

Single‐nucleotide polymorphisms (SNP) of ATP2B1 gene are associated with essential hypertension but their association with resistant hypertension (RHT) remains unexplored. The authors examined the relationship between ATP2B1 SNPs and RHT by genotyping 12 SNPs in ATP2B1 gene of 1124 Japanese individuals with lifestyle‐related diseases. Patients with RHT had inadequate blood pressure (BP) control using three antihypertensive drugs or used ≥4 antihypertensive drugs. Patients with controlled hypertension had BP controlled using ≤3 antihypertensive drugs. The association between each SNP and RHT was analyzed by logistic regression. The final cohort had 888 (79.0%) and 43 (3.8%) patients with controlled hypertension and RHT, respectively. Compared with patients homozygous for the minor allele of each SNP in ATP2B1, a significantly higher number of patients carrying the major allele at 10 SNPs exhibited RHT (most significant at rs1401982: 5.8% vs. 0.8%, p =.014; least significant at rs11105378: 5.7% vs. 0.9%, p =.035; most nonsignificant at rs12817819: 5.1% vs. 10%, p =.413). After multivariate adjustment for age, sex, systolic BP, and other confounders, the association remained significant for rs2681472 and rs1401982 (OR: 7.60, p <.05 and OR: 7.62, p =.049, respectively). Additionally, rs2681472 and rs1401982 were in linkage disequilibrium with rs11105378. This study identified two ATP2B1 SNPs associated with RHT in the Japanese population. rs1401982 was most closely associated with RHT, and major allele carriers of rs1401982 required significantly more antihypertensive medications. Analysis of ATP2B1 SNPs in patients with hypertension can help in early prediction of RHT and identification of high‐risk patients who are more likely to require more antihypertensive medications. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Author

Umemura, Satoshi, Arima, Hisatomi, Arima, Shuji, Asayama, Kei, Dohi, Yasuaki, Hirooka, Yoshitaka, Horio, Takeshi, Hoshide, Satoshi, Ikeda, Shunya, Ishimitsu, Toshihiko, Ito, Masaaki, Ito, Sadayoshi, Iwashima, Yoshio, Kai, Hisashi, Kamide, Kei, Kanno, Yoshihiko, Kashihara, Naoki, Kawano, Yuhei, Kikuchi, Toru, Kitamura, Kazuo, Kitazono, Takanari, Kohara, Katsuhiko, Kudo, Masataka, Kumagai, Hiroo, Matsumura, Kiyoshi, Matsuura, Hideo, Miura, Katsuyuki, Mukoyama, Masashi, Nakamura, Satoko, Ohkubo, Takayoshi, Ohya, Yusuke, Okura, Takafumi, Rakugi, Hiromi, Saitoh, Shigeyuki, Shibata, Hirotaka, Shimosawa, Tatsuo, Suzuki, Hiromichi, Takahashi, Shori, Tamura, Kouichi, Tomiyama, Hirofumi, Tsuchihashi, Takuya, Ueda, Shinichiro, Uehara, Yoshinari, Urata, Hidenori, and Hirawa, Nobuhito

Published
2019
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21. Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study

Author

Yamagata, Kunihiro, Usui, Joichi, Nagata, Michio, Sugiyama, Hitoshi, Sada, Ken-ei, Muso, Eri, Harigai, Masayoshi, Amano, Koichi, Atsumi, Tatsuya, Fujimoto, Shouichi, Yuzawa, Yukio, Kobayashi, Masaki, Saito, Takao, Ito, Takafumi, Hirawa, Nobuhito, Homma, Sakae, Dobashi, Hiroaki, Tsuboi, Naotaka, Ishizu, Akihiro, Arimura, Yoshihiro, Makino, Hirofumi, Matsuo, Seiichi, and For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan

Published
2019
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23. Omega-3 Fatty Acids Reduce Remnant-like Lipoprotein Cholesterol and Improve the Ankle–Brachial Index of Hemodialysis Patients with Dyslipidemia: A Pilot Study.

Author

Kobayashi, Yusuke, Fujikawa, Tetsuya, Haruna, Aiko, Kawano, Rina, Ozawa, Moe, Haze, Tatsuya, Komiya, Shiro, Suzuki, Shota, Ohki, Yuki, Fujiwara, Akira, Saka, Sanae, Hirawa, Nobuhito, Toya, Yoshiyuki, and Tamura, Kouichi

Subjects
OMEGA-3 fatty acids, HEMODIALYSIS patients, ANKLE brachial index, DYSLIPIDEMIA, DOCOSAHEXAENOIC acid
Abstract

Background and Objectives: Omega-3 fatty acids have potent lipid-lowering and antiplatelet effects; however, randomized controlled trials have yet to examine the effect of high-dose omega-3 fatty acid administration on peripheral artery disease (PAD) in hemodialysis patients with dyslipidemia. Therefore, this study aimed to evaluate the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the ankle–brachial index (ABI) and remnant-like lipoprotein cholesterol (RLP-C) levels, which are indicators of PAD severity. Materials and Methods: Thirty-eight participants (mean age: 73.6 ± 12.7 years) were randomly assigned using stratified block randomization to either conventional therapy alone or conventional therapy supplemented with high-dose EPA/DHA (EPA: 1860 mg; DHA: 1500 mg) for a three-month intervention period. Patients in the conventional therapy alone group who opted to continue were provided with a low-dose EPA/DHA regimen (EPA: 930 mg; DHA: 750 mg) for an additional three months. The baseline and 3-month values for RLP-C, an atherogenic lipid parameter, and the ABI were recorded. Results: The results of the 3-month assessments revealed that the mean RLP-C changes were −3.25 ± 3.15 mg/dL and 0.44 ± 2.53 mg/dL in the EPA/DHA and control groups, respectively (p < 0.001), whereas the changes in the mean ABI values were 0.07 ± 0.11 and −0.02 ± 0.09 in the EPA/DHA and control groups, respectively (p = 0.007). In the EPA/DHA group, a significant negative correlation was found between the changes in RLP-C levels and the ABI (r = −0.475, p = 0.04). Additionally, the change in the RLP-C levels independently influenced the change in the ABI in the EPA/DHA group, even after adjusting for age, sex, and statin use (p = 0.042). Conclusions: Add-on EPA/DHA treatment improved the effectiveness of conventional therapy (such as statin treatment) for improving the ABI in hemodialysis patients with dyslipidemia by lowering RLP-C levels. Therefore, clinicians involved in dialysis should focus on RLP-C when considering residual cardiovascular disease risk in hemodialysis patients and should consider screening patients with elevated levels. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry (J-RBR)

Author

Yokoyama, Hitoshi, Sugiyama, Hitoshi, Sato, Hiroshi, Taguchi, Takashi, Nagata, Michio, Matsuo, Seiichi, Makino, Hirofumi, Watanabe, Tsuyoshi, Saito, Takao, Kiyohara, Yutaka, Nishi, Shinichi, Iida, Hiroyuki, Morozumi, Kunio, Fukatsu, Atsushi, Sasaki, Tamaki, Tsuruya, Kazuhiko, Kohda, Yukimasa, Higuchi, Makoto, Kiyomoto, Hideyasu, Goto, Shin, Hattori, Motoshi, Hataya, Hiroshi, Kagami, Shoji, Yoshikawa, Norishige, Fukasawa, Yuichiro, Ueda, Yoshihiko, Kitamura, Hiroshi, Shimizu, Akira, Oka, Kazumasa, Nakagawa, Naoki, Ito, Takafumi, Uchida, Shunya, Furuichi, Kengo, Nakaya, Izaya, Umemura, Satoshi, Hiromura, Keiju, Yoshimura, Mitsuhiro, Hirawa, Nobuhito, Shigematsu, Takashi, Fukagawa, Masafumi, Hiramatsu, Makoto, Terada, Yoshio, Uemura, Osamu, Kawata, Tetsuya, Matsunaga, Akira, Kuroki, Aki, Mori, Yasukiyo, Mitsuiki, Koji, and Yoshida, Haruyoshi

Published
2012
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36. HYPERTENSION: EXPERIMENTAL

Author

Yasuda, Gen, Kinguchi, Sho, Katsumata, Mari, Hirawa, Nobuhito, and Shibata, Kazuhiko

Published
2014

37. Identification of Hypertension-Susceptibility Genes and Pathways by a Systemic Multiple Candidate Gene Approach: The Millennium Genome Project for Hypertension

Author

Kohara, Katsuhiko, Tabara, Yasuharu, Nakura, Jun, Imai, Yutaka, Ohkubo, Takayoshi, Hata, Akira, Soma, Masayoshi, Nakayama, Tomohiro, Umemura, Satoshi, Hirawa, Nobuhito, Ueshima, Hirotsugu, Kita, Yoshikuni, Ogihara, Toshio, Katsuya, Tomohiro, Takahashi, Norio, Tokunaga, Katsushi, and Miki, Tetsuro

Published
2008
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44. Adenosine A1 receptor and its gene expression in ventricles from spontaneously hypertensive rats

Author

Kobayashi, Shun-Ichi, Umemura, Satoshi, Toya, Yoshiyuki, Hirawa, Nobuhito, Hayashi, Shuuichi, Uchino, Kazuaki, and Ishii, Masao

Subjects
Rats -- Physiological aspects, Adenosine -- Physiological aspects, Heart -- Physiological aspects, Biological sciences
Abstract

Gene expression of the adenosine A1 receptor, which provides cardioprotection against myocardial ischemia and reperfusion, was investigated in ventricles of 6- and 13-week-old Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Receptor mRNA levels was similar for both groups at 13 weeks, but was higher in SHR than WKY at 6 weeks. Plasma adenosine levels were higher in SHR at 13 weeks. The differences in mRNA expression levels were attributed to desensitization of the receptors during ischemia.

Published
1996

48. Atherosclerosis of the carotid bulb is associated with the severity of orthostatic hypotension in non-diabetic adult patients: a cross-sectional study.

Author

Kobayashi, Yusuke, Ishiguro, Hiroaki, Fujikawa, Tetsuya, Kobayashi, Hideo, Sumida, Koichiro, Kagimoto, Minako, Okuyama, Yuki, Ehara, Yosuke, Katsumata, Mari, Fujita, Megumi, Fujiwara, Akira, Saka, Sanae, Yatsu, Keisuke, Hirawa, Nobuhito, Toya, Yoshiyuki, Yasuda, Gen, Umemura, Satoshi, and Tamura, Kouichi

Subjects
ORTHOSTATIC hypotension, CAROTID intima-media thickness, INTERNAL carotid artery, DYSAUTONOMIA, CAROTID artery
Abstract

Background: The carotid bulb has a high density of baroreceptors that play an important role in maintaining blood pressure. We hypothesized that atherosclerosis of the carotid bulb would reflect the severity of orthostatic hypotension more accurately than would atherosclerosis of other carotid artery segments. Methods: This cross-sectional study included 198 non-diabetic adults. We measured the cardio-vascular ankle index as an index of arterial stiffness, intima-media thickness in each carotid artery segment (internal carotid artery, carotid bulb, distal and proximal portions, respectively, of the common carotid artery) as a measure of atherosclerosis, and heart rate variability as a measure of cardiac autonomic function. The sit-to-stand test was used to assess severity of orthostatic hypotension. Results: Intima-media thickness of the carotid bulb was correlated with orthostatic systolic blood pressure change (r = −0.218, p = 0.002), cardio-ankle vascular index (r = 0.365, p < 0.001) and heart rate variability parameters. Multivariate regression analysis revealed that among all of the segments, only intima-media thickness of the carotid bulb was an independent predictor of orthostatic systolic blood pressure change (p = 0.022). Conclusion: Atherosclerosis of the carotid bulb was associated with severity of orthostatic hypotension, arterial stiffening and cardiac autonomic dysfunction than that of other carotid artery segments. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Plasma Cystine Levels and Cardiovascular and All‐Cause Mortality in Hemodialysis Patients.

Author

Suzuki, Shota, Shino, Midori, Fujikawa, Tetsuya, Itoh, Yoko, Ueda, Eiko, Hashimoto, Tatsuo, Kuji, Tadashi, Kobayashi, Naoyuki, Ohnishi, Toshimasa, Hirawa, Nobuhito, Tamura, Kouichi, and Toya, Yoshiyuki

Abstract

Abstract: Oxidative stress accelerates the development of cardiovascular disease. Plasma cystine, a thiol oxidative stress marker, is related to several established factors for cardiovascular disease risk and prognosis. Although a comprehensive oxidative stress index is clinically required for hemodialysis patients with high oxidative stress, there are few reports concerning thiol oxidative stress markers predicting their prognosis. We investigated the relationship between plasma amino acids including cystine levels and cardiovascular disease‐related and all‐cause mortality in 132 maintenance hemodialysis patients. Higher cystine levels were associated with old age, longer hemodialysis duration, hemodialysis‐associated hypotension, higher cardiothoracic ratio, higher blood urea nitrogen, and lower ankle‐brachial index. Multivariate Cox regression analysis revealed that high plasma cystine was independently related with both cardiovascular disease mortality and all‐cause mortality. Thus, high plasma cystine levels predict the prognosis of hemodialysis patients. High cystine levels necessitate a careful investigation for the cause of oxidative stress and comorbidities like vascular injury. [ABSTRACT FROM AUTHOR]

Published
2018
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