23 results on '"Heslop C"'
Search Results
2. AES and XPS studies of surface films deposited during the plasma etching of silicon dioxide layers.
- Author
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Tuppen, C. G., Heckingbottom, R., Gill, M., Heslop, C., and Davies, G. J.
- Published
- 1984
- Full Text
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3. Surface analysis.
- Author
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Huddleston, J., Hutchinson, I. G., Pierce, T. B., Davies, G. J., Tuppen, C. G., Heckingbottom, R., Gill, M., Heslop, C., Christie, A. B., Sutherland, I., Lee, J., Walls, J. M., Vickerman, J. C., Keenlyside, M., Stott, F. H., and Wood, G. C.
- Published
- 1983
- Full Text
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4. BIOMARKERS OF OXIDATIVE STRESS: RELATIVE PREDICTIVE VALUE FOR CARDIOVASCULAR MORTALITY.
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Heslop, C. L., Hill, J. S., and Frohlich, J. J.
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- 2006
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5. The measurement of p - n junction depths using a scanning electron microscope.
- Author
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Heslop, C. J. and Ward, E. W.
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- 1971
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6. Intravenous fluid therapy: an audit and discussion of improvements required for prescribers and administrators.
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Heslop C, Rajpara M, Wood S, Patel T, Karelia S, and Patel R
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- Humans, England, Infusions, Intravenous standards, State Medicine, Practice Guidelines as Topic, Administration, Intravenous, Quality Improvement, Medical Audit, Fluid Therapy standards, Guideline Adherence
- Abstract
Background: Foundation doctors and nurses are the clinicians most closely involved in fluid assessment, intravenous (IV) fluid prescription and administration. However, both groups report challenges regarding IV fluids. At a large NHS trust in England, adherence to the National Institute for Health and Care Excellence (NICE) guideline CG174, regarding IV fluids, was largely unknown., Aims: To assess the baseline adherence, within the hospitals, to CG174 and identify areas for improvement., Methods: A set of 12 audit standards were developed and used to collect data across 29 clinical areas between September 2022 and May 2023, with 255 patients receiving IV fluids at any time during their inpatient stay included., Findings: For two standards target adherence of 95% was achieved, with an adherence less than 50% in most. Areas of particularly poor adherence included assessing and meeting fluid and electrolyte requirements, patient reassessment and developing IV fluid management plans., Conclusion: Trust baseline adherence to NICE CG174 requires improvement, particularly regarding patient assessment and reassessment, and meeting electrolyte requirements.
- Published
- 2024
- Full Text
- View/download PDF
7. Delivering Point-of-Care ultrasound teaching using a video conferencing technique.
- Author
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Tang E, Daniel R, Wintraub L, Nelms MW, Heslop C, Cho DD, and Otremba M
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- Humans, Ultrasonography methods, Point-of-Care Testing, Videoconferencing, Point-of-Care Systems, Students, Medical
- Abstract
Point-of-care ultrasound (POCUS) has usually been taught using a hands-on, in-person approach. We present a novel approach to delivering POCUS virtually using a dual image videoconferencing technique. We outline an easily implementable approach and summarize medical students' experience and feedback. This form of delivery has potential to improve instructional delivery in resource restricted settings or during pandemic restrictions where a hands-on approach may not be possible., Competing Interests: None Declared, (© 2023 Tang, Daniel, Wintraub, Nelms, Heslop, Cho, Otremba; licensee Synergies Partners.)
- Published
- 2023
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8. Point of Care Ultrasound Literature Primer: Key Papers on Focused Assessment With Sonography in Trauma (FAST) and Extended FAST.
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Kim DJ, Bell C, Jelic T, Sheppard G, Robichaud L, Burwash-Brennan T, Chenkin J, Lalande E, Buchanan I, Atkinson P, Thavanathan R, Heslop C, Myslik F, and Lewis D
- Abstract
Objective The objective of this study is to identify the top five most influential papers published on focused assessment with sonography in trauma (FAST) and the top five most influential papers on the extended FAST (E-FAST) in adult patients. Methods An expert panel was recruited from the Canadian Association of Emergency Physicians (CAEP) Emergency Ultrasound Committee and the Canadian Ultrasound Fellowship Collaborative. These experts are ultrasound fellowship-trained or equivalent, are involved with point-of-care ultrasound (POCUS) research and scholarship, and are leaders in both the POCUS program at their local site and within the national Canadian POCUS community. This 14-member expert group used a modified Delphi process consisting of three rounds of sequential surveys and discussion to achieve consensus on the top five most influential papers for FAST and E-FAST. Results The expert panel identified 56 relevant papers on FAST and 40 relevant papers on E-FAST. After completing all three rounds of the modified Delphi process, the authors identified the top five most influential papers on FAST and the top five most influential papers on E-FAST. Conclusion We have developed a reading list of the top five influential papers for FAST and E-FAST that will benefit residents, fellows, and clinicians who are interested in using POCUS in an evidence-informed manner., Competing Interests: The authors have declared financial relationships, which are detailed in the next section., (Copyright © 2022, Kim et al.)
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- 2022
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9. Mental health among elite sportspeople: Lessons for medical education.
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Walker I, Brierley E, Patel T, Jaffer R, Rajpara M, Heslop C, and Patel R
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- Curriculum, Female, Humans, Mental Health, Education, Medical, Sports psychology
- Abstract
Leading sportspeople across 2021, such as Simone Biles (US gymnast), Naomi Osaka (Japanese tennis player) and Ben Stokes (English cricketer), have talked openly about the pressure of performing on the highest stage, including the challenge of managing mental health when engaged in elite competition. The withdrawal of Simone Biles midway through the women's team competition at the Tokyo 2020 Olympic Games propelled what was seemingly a debate within sport, into what is increasing becomingly wider societal conversation around mental health. The stories of sportspeople struggling to perform at the highest level with mental health contributing to their difficulties, has inevitably prompted much reflection within medical education among teachers and students alike, about parallels in our domain around assessment, feedback and support. The stories demonstrate that mental health problems affect everyone, including those who are at their peak physically, and those who are among the finest on the planet in terms of physical and sporting ability. The same is true within medical education of our students, who are also our future doctors. However, curriculum conversations about assessment, feedback and student support may not be as student-centred as they could be, or perhaps as they should be, with mental health possibly still being a taboo-subject or something associated with stigma within medical education. Here is another opportunity for medical education to learn from other disciplines, such as sports psychology, and now is the time for taking and applying those lessons: not just those around improving technical performance, but those around properly caring, being compassionate, and looking after our future Olympian equivalents.
- Published
- 2022
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10. Misinterpretation of Recommendations from the CAEP Emergency Ultrasound Committee as a Case Report.
- Author
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Kim DJ, Jelic T, Woo MY, Heslop C, and Olszynski P
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- Humans, Ultrasonography, Emergency Service, Hospital
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- 2021
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11. Just the Facts: Recommendations on point-of-care ultrasound use and machine infection control during the coronavirus disease 2019 pandemic.
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Kim DJ, Jelic T, Woo MY, Heslop C, and Olszynski P
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- Betacoronavirus, COVID-19, Coronavirus Infections prevention & control, Coronavirus Infections transmission, Humans, Pandemics prevention & control, Pneumonia, Viral prevention & control, Pneumonia, Viral transmission, SARS-CoV-2, Coronavirus Infections diagnostic imaging, Equipment Contamination prevention & control, Infection Control organization & administration, Pneumonia, Viral diagnostic imaging, Point-of-Care Systems, Ultrasonography
- Abstract
The World Health Organization declared the novel coronavirus disease 2019 (COVID-19) to be a pandemic on March 11, 2020, and, currently, there are over 10,000 confirmed cases in Canada, with this number expected to grow exponentially. There has been widespread interest in the use of point-of-care ultrasound (POCUS) in the management of patients with suspected COVID-19. The CAEP Emergency Ultrasound Committee has developed recommendations on the use of POCUS in these patients, with an emphasis on machine infection control measures.
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- 2020
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12. Lung point-of-care ultrasound, an opportunity to improve patient care and patient-oriented outcomes.
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Barbic D, Jelic T, Chenkin J, Heslop C, and Atkinson P
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- Emergency Service, Hospital, Humans, Patient Care, Point-of-Care Systems, Prospective Studies, Ultrasonography, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Published
- 2020
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13. Ultrasound at the point of care - Grown up and moving out!
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Olszynski P, Heslop C, Atkinson P, Lewis D, Kim DJ, Pham C, and Ritcey B
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- Humans, Ultrasonography, Emergency Medicine, Point-of-Care Systems
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- 2020
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14. AccessLab: Workshops to broaden access to scientific research.
- Author
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Griffiths AGF, Modinou I, Heslop C, Brand C, Weatherill A, Baker K, Hughes AE, Lewis J, de Mora L, Mynott S, Roberts KE, and Griffiths DJ
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- Research Personnel, Congresses as Topic, Research, Science
- Abstract
AccessLabs are workshops with two simultaneous motivations, achieved through direct citizen-scientist pairings: (1) to decentralise research skills so that a broader range of people are able to access/use scientific research, and (2) to expose science researchers to the difficulties of using their research as an outsider, creating new open access advocates. Five trial AccessLabs have taken place for policy makers, media/journalists, marine sector participants, community groups, and artists. The act of pairing science academics with local community members helps build understanding and trust between groups at a time when this relationship appears to be under increasing threat from different political and economic currents in society. Here, we outline the workshop motivations, format, and evaluation, with the aim that others can build on the methods developed., Competing Interests: The authors have declared that no competing interests exist.
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- 2019
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15. Managing qualitative research as insider-research in small rural communities.
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Heslop C, Burns S, and Lobo R
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- Ethics, Research, Humans, Interpersonal Relations, Physicians, Research Personnel ethics, Research Personnel psychology, Qualitative Research, Rural Population
- Abstract
Rural clinicians in small communities face the pressure of always being 'on duty', and the ethical challenges of overlapping relationships with members of the community and duality of roles. The lead author of this commentary has experience as an insider researcher living within a small rural community, and has navigated the ethical challenges and community pressures of conducting qualitative research within an interconnected network. With appropriate measures and planning, insider research can be conducted rigorously, while maintaining ongoing relationships, confidentiality and anonymity.
- Published
- 2018
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16. Defining the learning curve of point-of-care ultrasound for confirming endotracheal tube placement by emergency physicians.
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Chenkin J, McCartney CJ, Jelic T, Romano M, Heslop C, and Bandiera G
- Abstract
Background: Unrecognized esophageal intubations are associated with significant patient morbidity and mortality. No single confirmatory device has been shown to be 100 % accurate at ruling out esophageal intubations in the emergency department. Recent studies have demonstrated that point-of-care ultrasound (POCUS) may be a useful adjunct for confirming endotracheal tube placement; however, the amount of practice required to become proficient at this technique is unclear. The purpose of this study is to determine the amount of practice required by emergency physicians to become proficient at interpreting ultrasound video clips of esophageal and endotracheal intubations., Methods: Emergency physicians and emergency medicine residents completed a baseline interpretation test followed by a 10 min online tutorial. They then interpreted POCUS clips of esophageal and endotracheal intubations in a randomly selected order. If an incorrect response was provided, the participant completed another practice session with feedback. This process continued until they correctly interpreted ten consecutive ultrasound clips. Descriptive statistics were used to summarize the data., Results: Of the 87 eligible physicians, 66 (75.9 %) completed the study. The mean score on the baseline test was 42.9 % (SD 32.7 %). After the tutorial, 90.9 % (60/66) of the participants achieved proficiency after one practice attempt and 100 % achieved proficiency after two practice attempts. Six intubation ultrasound clips were misinterpreted, for a total error rate of 0.9 % (6/684). Overall, the participants had a sensitivity of 98.3 % (95 % CI 96.3-99.4 %) and specificity of 100 % (95 % CI 98.9-100 %) for detecting correct tube location. Scans were interpreted within an average of 4 s (SD 2.9 s) of the intubation., Conclusions: After a brief online tutorial and only two practice attempts, emergency physicians were able to quickly and accurately interpret ultrasound intubation clips of esophageal and endotracheal intubations.
- Published
- 2015
- Full Text
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17. There Are Sex Differences in the Demographics and Risk Profiles of Emergency Department (ED) Patients With Atrial Fibrillation and Flutter, but no Apparent Differences in ED Management or Outcomes.
- Author
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Scheuermeyer FX, Mackay M, Christenson J, Grafstein E, Pourvali R, Heslop C, MacPhee J, Ward J, Heilbron B, McGrath L, and Humphries K
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- Aged, Aged, 80 and over, Atrial Fibrillation diagnosis, Atrial Flutter diagnosis, Comorbidity, Electrocardiography, Female, Hospitals, Urban, Humans, Length of Stay, Male, Middle Aged, Patient Discharge statistics & numerical data, Patient Readmission statistics & numerical data, Retrospective Studies, Risk Factors, Sex Factors, Socioeconomic Factors, Atrial Fibrillation epidemiology, Atrial Fibrillation therapy, Atrial Flutter epidemiology, Atrial Flutter therapy, Emergency Service, Hospital statistics & numerical data
- Abstract
Objectives: In non-emergency department (ED) settings, women with atrial fibrillation and flutter (AFF) have different presentations, treatments, and outcomes than men: they are older, less likely to be treated with rhythm control strategies or appropriate anticoagulation, and more likely to have strokes. This has not been investigated in ED patients., Methods: Records from consecutive ED patients from January 1 to December 31, 2009, with electrocardiogram-proven AFF at two urban hospitals were collected. Review of administrative and clinical data identified patient demographics, clinical characteristics, comorbidities, and ED treatments. The regional ED database was queried to determine 30-day and 1-year follow-up visits, and the provincial vital statistics database was referenced to obtain 30-day and 1-year mortality; all outcomes were stratified by sex. The primary outcome, which reflected overall appropriateness of ED care, was the proportion of patients who were discharged home at their index ED visits, who then had unscheduled 30-day ED revisits. Secondary outcomes included the proportion of eligible patients who underwent acute rhythm control strategies and the proportion of high-risk patients who had previously inadequately anticoagulation strategies corrected by the emergency physician. Additional outcomes included the ED length of stay (LOS) and 30-day and 1-year rates of stroke and death., Results: A total of 1,112 records were reviewed: 470 women (42.3%) and 642 men. Women were a median 8 years (interquartile range = 3 to 13 years) older than men, had higher rates of cardiovascular comorbidities, and were more likely to present with atypical symptoms such as weakness or dyspnea. On their index ED visits, 50.2% of women and 41.3% of men were admitted. At 30 days, 39 of 234 (16.7%) women and 55 of 377 (14.6%) men who were discharged at their index ED visits had made revisits, for a risk difference of 2.1% (95% confidence interval = -3.9% to 8.5%). There were no apparent sex differences in the use of acute rhythm control or in the appropriateness of anticoagulation decisions. ED LOS was similar between women and men, as were 30-day and 1-year stroke or death rates., Conclusions: Female ED AFF patients were older, had more comorbidities, and were more likely to be admitted. However, the overall management and outcomes, including 30-day revisits, appeared to be similar to that of males, indicating that there appeared to be little sex-based discrepancy in ED care and outcomes., (© 2015 by the Society for Academic Emergency Medicine.)
- Published
- 2015
- Full Text
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18. Emergency Department Patients With Atrial Fibrillation or Flutter and an Acute Underlying Medical Illness May Not Benefit From Attempts to Control Rate or Rhythm.
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Scheuermeyer FX, Pourvali R, Rowe BH, Grafstein E, Heslop C, MacPhee J, McGrath L, Ward J, Heilbron B, and Christenson J
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- Acute Disease, Adult, Aged, Aged, 80 and over, Atrial Fibrillation etiology, Atrial Flutter etiology, Cohort Studies, Female, Humans, Logistic Models, Male, Middle Aged, Retrospective Studies, Treatment Outcome, Anti-Arrhythmia Agents therapeutic use, Atrial Fibrillation drug therapy, Atrial Flutter drug therapy, Emergency Service, Hospital
- Abstract
Study Objective: Although the management and outcomes of emergency department (ED) patients with atrial fibrillation or flutter have been explored, such studies have typically excluded patients with acute underlying medical illnesses. We seek to describe the ED treatment and outcomes of these complex patients with atrial fibrillation or flutter., Methods: This retrospective descriptive cohort study used an ECG database from 2 urban EDs to identify consecutive ED patients with an ECG demonstrating atrial fibrillation or flutter from January 1, 2009, to December 31, 2009. We categorized patients with atrial fibrillation or flutter as "complex" according to prespecified criteria and then grouped them as being managed with rate or rhythm control attempts, or not. The primary outcome was safety of rate or rhythm control, measured by whether patients had a predefined adverse event or not. The secondary outcome was the success of rate or rhythm control, defined as rate control decreasing the pulse rate by 20 beats/min and successful rhythm control, both within 4 hours of treatment initiation. Descriptive statistics were used to compare the 2 groups., Results: Four hundred sixteen complex patients with atrial fibrillation or flutter were identified. Patients managed with rate or rhythm control were similar in all baseline characteristics and illness distribution to patients who were not managed in this manner. The 135 patients with attempted rate control (105) or rhythm control (30) had 55 adverse events (40.7%; 95% confidence interval [CI] 32.5% to 49.5%), whereas the 281 patients not managed with rate or rhythm control had 20 adverse events (7.1%; 95% CI 4.5% to 10.9%), for a risk difference of 33.6% (95% CI 24.3% to 42.5%) and a relative risk of 5.7 (95% CI 3.6 to 9.1). Twenty of 105 patients (19.1%; 95% CI 12.3% to 28.1%) were successfully rate controlled, whereas 4 of 30 (13.3%; 95% CI 4.4% to 31.6%) were successfully rhythm controlled., Conclusion: In ED patients with complex atrial fibrillation or flutter, attempts at rate and rhythm control are associated with a nearly 6-fold higher adverse event rate than that for patients who are not managed with rate or rhythm control. Success rates of rate or rhythm control attempts appear low., (Copyright © 2014 American College of Emergency Physicians. Published by Elsevier Inc. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
19. Missed opportunities for appropriate anticoagulation among emergency department patients with uncomplicated atrial fibrillation or flutter.
- Author
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Scheuermeyer FX, Innes G, Pourvali R, Dewitt C, Grafstein E, Heslop C, MacPhee J, Ward J, Heilbron B, McGrath L, and Christenson J
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- Aged, Aged, 80 and over, Atrial Fibrillation therapy, Atrial Flutter therapy, Female, Guideline Adherence, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Stroke prevention & control, Warfarin therapeutic use, Anticoagulants therapeutic use, Atrial Fibrillation complications, Atrial Flutter complications, Emergency Service, Hospital statistics & numerical data
- Abstract
Study Objective: Emergency department (ED) patients with atrial fibrillation or flutter are at risk of stroke, and guidelines recommend anticoagulation for patients with increased cardiovascular risk. Emergency physicians have a unique opportunity to provide appropriate anticoagulation for such patients, and we wished to investigate whether this was accomplished., Methods: This retrospective cohort study used a database from 2 urban EDs to identify consecutive patients with an ED discharge diagnosis of atrial fibrillation or flutter from April 1, 2006, to March 31, 2010, who were managed solely by the emergency physician. Comorbidities, rhythms, and management were obtained by chart review, and complicated patients (those with an acute underlying medical condition) were excluded by predefined criteria. Patient medications on ED presentations were obtained through the provincial Pharmanet database. Patients were stratified into CHADS 2 (congestive heart failure, hypertension, age > 75, diabetes, stroke/transient ischemic attack) scores, and the primary outcome was the proportion of higher-risk (CHADS 2 score >0) patients who were discharged home with the incorrect anticoagulation by the emergency physician. The secondary outcome was the number of lower-risk (CHADS 2=0) patients who began receiving warfarin by the emergency physician orders. The regional ED database was interrogated to ascertain the number of patients who had a stroke at 30 days., Results: Consecutive patients (1,090) were enrolled and 732 were discharged home with no cardiology consultation (657 fibrillation and 75 flutter). Of 151 higher-risk (CHADS 2 score >0) patients who should have been anticoagulated, 80 (53.0%; 95% confidence interval 44.7% to 61.0%) were discharged home from the ED without appropriate anticoagulation. In this group, 1 patient had an ischemic stroke at 24 days. Among 300 lower-risk patients (CHADS 2 score=0), 25 (8.3%; 95% confidence interval 5.6% to 12.2%) had warfarin initiated., Conclusion: In this cohort of ED patients with uncomplicated atrial fibrillation or flutter who were discharged without cardiology involvement, many were not appropriately anticoagulated before ED arrival, and more than half of such patients did not appear to have corrective measures initiated by the emergency physician. This may represent a potential opportunity to improve patient care and outcomes., (Copyright © 2013 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.)
- Published
- 2013
- Full Text
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20. Safety and efficiency of calcium channel blockers versus beta-blockers for rate control in patients with atrial fibrillation and no acute underlying medical illness.
- Author
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Scheuermeyer FX, Grafstein E, Stenstrom R, Christenson J, Heslop C, Heilbron B, McGrath L, and Innes G
- Subjects
- Adrenergic beta-Antagonists adverse effects, Aged, Aged, 80 and over, Atrial Fibrillation epidemiology, Calcium Channel Blockers adverse effects, Canada epidemiology, Cohort Studies, Comorbidity, Female, Humans, Male, Middle Aged, Retrospective Studies, Stroke epidemiology, Adrenergic beta-Antagonists therapeutic use, Atrial Fibrillation drug therapy, Calcium Channel Blockers therapeutic use, Heart Rate drug effects, Patient Admission statistics & numerical data
- Abstract
Objectives: Many patients with atrial fibrillation (AF) are not candidates for rhythm control and may require rate control, typically with beta-blocking (BB) or calcium channel blocking (CCB) agents. Although these patients appear to have a low 30-day rate of stroke or death, it is unclear if one class of agent is safer or more effective. The objective was to determine whether BBs or CCBs would have a lower hospital admission rate and to measure 30-day safety outcomes including stroke, death, and emergency department (ED) revisits., Methods: This retrospective cohort study used a database from two urban EDs to identify consecutive patients with ED discharge diagnoses of AF from April 1, 2006, to March 31, 2010. Comorbidities, rhythms, management, and immediate outcomes were obtained by manual chart review, and patients with acute underlying medical conditions were excluded by predefined criteria. Patients managed only with rate control agents were eligible for review, and patients receiving BB agents were compared to those receiving CCB agents. The primary outcome was the proportion of patients requiring hospital admission; secondary outcomes included the ED length of stay (LOS), the proportion of patients having adverse events, the proportion of patients returning within 7 or 30 days, and the number of patients having a stroke or dying within 30 days., Results: A total of 259 consecutive patients were enrolled, with 100 receiving CCBs and 159 receiving BBs. Baseline demographics and comorbidities were similar. Twenty-seven percent of BB patients were admitted, and 31.0% of CCB patients were admitted (difference = 4.0%, 95% confidence interval [CI] = -7.7% to 16.1%), and there were no significant differences in ED LOS, adverse events, or 7- or 30-day ED revisits. One patient who received metoprolol had a stroke, and one patient who received diltiazem died within 30 days., Conclusions: In this cohort of ED patients with AF and no acute underlying medical illness who underwent rate control only, patients receiving CCBs had similar hospital admission rates to those receiving BBs, while both classes of medications appeared equally safe at 30 days. Both CCBs and BBs are acceptable options for rate control., (© 2013 by the Society for Academic Emergency Medicine.)
- Published
- 2013
- Full Text
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21. Thirty-day and 1-year outcomes of emergency department patients with atrial fibrillation and no acute underlying medical cause.
- Author
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Scheuermeyer FX, Grafstein E, Stenstrom R, Innes G, Heslop C, MacPhee J, Pourvali R, Heilbron B, McGrath L, and Christenson J
- Subjects
- Aged, Aged, 80 and over, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Atrial Fibrillation mortality, Atrial Fibrillation therapy, Humans, Male, Middle Aged, Retrospective Studies, Stroke epidemiology, Stroke etiology, Time Factors, Treatment Outcome, Atrial Fibrillation epidemiology, Emergency Service, Hospital statistics & numerical data
- Abstract
Study Objective: Atrial fibrillation is the most common dysrhythmia observed in the emergency department (ED), yet there is little research describing long-term outcomes after ED management. Our objective is to describe ED treatment approach, conversion success rates, ED adverse events, and 30-day and 1-year outcomes for a cohort of ED patients with atrial fibrillation and no acute underlying medical cause., Methods: This retrospective cohort study used a database from 2 urban EDs to identify consecutive patients with an ED discharge diagnosis of atrial fibrillation from April 1, 2006, to March 31, 2010. Comorbidities, rhythms, management, and immediate outcomes were obtained by manual chart review, and patients with an acute underlying medical condition were excluded by predefined criteria. Patients were stratified into 5 groups according to ED management: electrocardioversion, chemical cardioversion, spontaneous cardioversion, rate control only, and no arrhythmia-specific treatment. To identify deaths, strokes, and ED revisits within 1 year, each patient's unique provincial health number was linked to the provincial vital statistics registry and the regional ED database. Primary outcome was the number of patients having either stroke or death of any cause at 30 days, stratified by treatment group., Results: Of 927 consecutive eligible patients, 121 (13.1%) converted to sinus rhythm before ED intervention, 357 (38.5%) received ED rhythm control, and 449 (48.4%) did not receive rhythm control. Overall, 142 of 927 patients (15.3%) were admitted to the hospital at the index ED visit. At 30 days, 2 patients had a stroke and 5 died (combined outcome rate 0.8%; 95% confidence interval 0.3% to 1.6%). All 7 of these patients were admitted at the index ED visit., Conclusion: In this large cohort of ED patients with atrial fibrillation and no acute underlying medical cause, the 30-day rate for stroke or death was less than 1%. Nearly 85% of patients-regardless of treatment approach or conversion to sinus rhythm-were discharged at the index ED visit, and none of these patients had a stroke or died at 30 days., (Copyright © 2012. Published by Mosby, Inc.)
- Published
- 2012
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22. Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality.
- Author
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Hill J, Heslop C, Man SF, Frohlich J, Connett JE, Anthonisen NR, Wise RA, Tashkin DP, and Sin DD
- Subjects
- Adult, Biomarkers blood, Cardiovascular Diseases blood, Chronic Disease, Cohort Studies, Female, Hospitalization statistics & numerical data, Humans, Interleukin-6 metabolism, Male, Middle Aged, Pneumonia blood, Pneumonia mortality, Prognosis, ROC Curve, Risk Factors, Cardiovascular Diseases mortality, Pulmonary Surfactant-Associated Protein D blood
- Abstract
Aims: Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD., Methods and Results: Plasma SP-D levels were measured in 806 patients who underwent coronary angiography to assess its predictive value for cardiovascular mortality. Serum SP-D levels were also measured in a replication cohort to assess its relationship with CVD events in 4468 ex- and current smokers without a known history of coronary artery disease (CAD). Patients who died during follow-up had significantly higher plasma SP-D levels than those who survived (median 85.4 vs. 64.8 ng/mL; P < 0.0001). Those in the highest quintile of SP-D had 4.4-fold higher risk of CVD mortality than those in the lowest quintile (P < 0.0001) independent of age, sex, and plasma lipid levels. In a group of current and ex-smokers without a known history of CAD, serum SP-D levels were elevated in those who died or were hospitalized for CVD compared with those who did not (median 99.8 vs. 90.6 ng/mL; P = 0.0001)., Conclusion: Circulating SP-D is a good predictor of cardiovascular morbidity and mortality and adds prognostic information to well-established risk factors such as age, sex, and plasma lipids and is a promising biomarker to link lung inflammation/injury to CVD.
- Published
- 2011
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23. An Outbreak of Myoglobinuria in Light Horses.
- Author
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Pope DC and Heslop CH
- Published
- 1960
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