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1. The Impact of Ferric Derisomaltose on Cardiovascular and Noncardiovascular Events in Patients With Anemia, Iron Deficiency, and Heart Failure With Reduced Ejection Fraction

Author

Kalra, Paul, Cowan, Elena, Howe, Serena, Turner, Charlotte, Austin, Rosalynn, Lane, Rebeca, Rogers, Paula, Foley, Paul, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, Ahmed, Fozia, Petrie, Mark, McGregor, Lorraine, Osmanska, Joanna, Graham, Fraser, Lang, Ninian, Meyer, Barbara, Ahmad, Faheem, Squire, Iain, Fisher, Jude, Kalra, Philip, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Ludman, Andrew, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Cowburn, Peter, Frank, Sarah, Smith, Simon, Japp, Alan, Anwar, Mohamed, Whittington, Beth, Seed, Alison, Ray, Robin, Sookhoo, Vennessa, Al-Mohammad, Abdallah, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Pellicori, Pierpaolo, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Tavares, Sara, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Chapman, Callum, Piper, Susan, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Nightingale, Angus, Thomson, Elizabeth, Ford, Ian, Robertson, Michele, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Sandu, Pamela, Surtees, Pamela, Stuart, Debra, Cleland, John G.F., Ahmed, Fozia Z., Cowburn, Peter J., Critoph, Chris, Kalra, Philip A., Lane, Rebecca E., Petrie, Mark C., Robertson, Michelle, and Kalra, Paul R.

Published
2024
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2. Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial

Author

Kalra, Paul R, Cleland, John GF, Petrie, Mark C, Thomson, Elizabeth A, Kalra, Philip A, Squire, Iain B, Ahmed, Fozia Z, Al-Mohammad, Abdallah, Cowburn, Peter J, Foley, Paul WX, Graham, Fraser J, Japp, Alan G, Lane, Rebecca E, Lang, Ninian N, Ludman, Andrew J, Macdougall, Iain C, Pellicori, Pierpaolo, Ray, Robin, Robertson, Michele, Seed, Alison, Ford, Ian, Boon, Nicholas, Amoils, Shannon, Chapman, Callum, Diness, Thomas G, McMurray, John, Mindham, Richard, Sandu, Pamela, Strom, Claes C, Travers, Maureen, Wilcox, Robert, Struthers, Allan, Mark, Patrick, Weir, Christopher, Cowan, Elena, Turner, Charlotte, Austin, Rosalynn, Rogers, Paula, Chandrasekaran, Badri, Fraile, Eva, Kyeremeh, Lynsey, McGregor, Lorraine, Osmanska, Joanna, Meyer, Barbara, Ahmad, Faheem, Fisher, Jude, Summersgill, Christina, Adeniji, Katarzyna, Chinnadurai, Rajkumar, Massimo, Lisa, Hardman, Clare, Sykes, Daisy, Frank, Sarah, Smith, Simon, Anwar, Mohamed, Whittington, Beth, Sookhoo, Vennessa, Lyons, Sinead, Middle, Janet, Housley, Kay, Clark, Andrew, Bulemfu, Jeanne, Critoph, Christopher, Chong, Victor, Wood, Stephen, Szwejkowski, Benjamin, Lang, Chim, Duff, Jackie, MacDonald, Susan, Schiff, Rebekah, Donnelly, Patrick, Nageh, Thuraia, Kunhunny, Swapna, Gardner, Roy, McAdam, Marion, McPherson, Elizabeth, Banerjee, Prithwish, Sear, Eleanor, Edwards, Nigel, Glover, Jason, Murphy, Clare, Cooke, Justin, Spencer, Charles, Francis, Mark, Matthews, Iain, McKie, Hayley, Marshall, Andrew, Large, Janet, Stratford, Jenny, Clifford, Piers, Boos, Christopher, Keeling, Philip, Hughes, Debbie, Wong, Aaron, Jones, Deborah, James, Alex, Williams, Rhys, Leslie, Stephen, Finlayson, Jim, Hannah, Andrew, Campbell, Philip, Walsh, John, Quinn, Jane, Piper, Susan, Patale, Sheetal, Gupta, Preeti, Sim, Victor, Knibbs, Lucy, Lyons, Kristopher, Dixon, Lana, Petrie, Colin, Wong, Yuk-ki, Labinjoh, Catherine, Duckett, Simon, Massey, Ian, Savage, Henry, Matias, Sofia, Ramirez, Jonaifah, Manisty, Charlotte, Hussain, Ifza, Sankaranarayanan, Rajiv, Davis, Gershan, McClure, Samuel, Baxter, John, Wicks, Eleanor, Sobolewska, Jolanta, Murphy, Jerry, Elzayat, Ahmed, Cooke, Alastair, Wright, Jay, Williams, Simon, Muthumala, Amal, Chaggar, Parminder, Webber, Sue, Ellis, Gethin, Welch, Mandie, Bulugahapitiya, Sudantha, Jackson, Thomas, Pakrashi, Tapesh, Bakhai, Ameet, Krishnamurthy, Vinodh, Gamma, Reto, Ellery, Susan, Jenkins, Geraint, Thomas, Gladdys, Nightingale, Angus, Greenlaw, Nicola, Wetherall, Kirsty, Clarke, Ross, Graham, Christopher, Kean, Sharon, Stevenson, Alan, Wilson, Robbie, Boyle, Sarah, McHugh, John, Hall, Lisa, Woollard, Joanne, Brunton, Claire, Dinnett, Eleanor, Reid, Amanda, Howe, Serena, Nicholls, Jill, Cunnington, Anna, Douglas, Elizabeth, Fegen, Margaret, Jones, Marc, McGowan, Sheila, Ross, Barbara, Surtees, Pamela, Stuart, Debra, Cleland, John G F, and Foley, Paul W X

Published
2022
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4. The acute management of ankle fractures (Augment) study: A prospective trainee led national collaborative audit of the Boast 12 guidelines

Author

Yousuf, Umar, Senthilkumaran, Sriskandarasa, Kumar, Vish, Korde, Vinayak, Baigent, Thomas, Mahmood, Fahd, Shin, Je Song, Haines, Samuel, Dominguez, Elizabeth, Monsell, Fergal, Armbruster, Berenice Aguirrezabala, Hakim, Muhammad Aadil, Dewar, Greg, Kozhikunnath, Arun, Rai, Praveen, Adebayo, Oliver, Reddy, Rajesh Gopi, Mishra, Arya, Tadros, John, Black, Jonathon, Willmott, Henry, Robertson, Alastair, Rae, Fraser, Macleod, Calum, Macleod, Lewis, Tan, Harriet, Smith, Ben, Chuter, Graham, Slade, Henry, Javed, Omar, Adamu-Biu, Fatima, Ho, Beatrice, Williams, Mark, Stedman, Tobias, Bull, Eleanor, Abiddin, Zain, Hannah, Andrew, Fananapazir, Leila, Del Rosario-Caluya, Christine, Hassan, Abdul Rahman, Howe, Thomas, Carr, Alastair, Arnaout, Firas, Knapper, Thomas, Fleming, Tom, Everett, Samuel James, Jordan, Stevan, Fowler, Tim, Grice, John, Taylor, Alexander, Crosswell, Sebastien, Campion, Alice, Bissell, Iain, Al-Kaisi, Kahlan, Paavana, Thumri, Neal-Smith, Gregory, Bretherton, Chris, Dowlut, Naeem, Gourbault, Lysander, Goh, En Lin, Costa, Matthew, Wadkin, James, Harris, Maredudd, Gill, Ian, Siddiqui, Nashat, White, Andrew, Chawla, Amit, Dalwai, Ramesh, Dixit, Anurag, Papachristou, Athanasios, Sharma, Akshat, Thomas, Osmond, Clifton, Laura, Wong, Huan, Tweedie, Blair, Drake, Benjamin, Khan, Sameer, Townshend, David, Barnard, Emily, Ward, Alex, Madhvani, Kiran, de Boer, Henry, Clark, Matthew, Naveed, Umna, Chahal, Gurdip, Watts, Anna, Barkley, Sarah, Doorgakant, Ashtin, Blundell, Chris, Price, Michael, Harrison, Peter, Wright, Jake, Lesko, Laszlo, Osman, Khabab, Hartley, Laura, Uhiara, Okezika, Marsh, Alastair, Lloyd, Adam, Naguleswaran, Sinthuja, Khamdan, Khadija, Hartshorn, Rebecca, Sood, Abhay, Divecha, Hiren, Bryony, Peiris, Jaibaji, Monketh, McAndrew, Andrew, Kennedy, James, Yusuf, Muhammad, Rogers, Sophie, Hodhody, Ghazal, Jones, Matt, King, Andrew, Agrawal, Somen, Stephens, Christian Gray, Davies-Jones, Gareth, Pirozekova, Lucia, Vick, Oliver, Kay, Robert, Keating, John, Walsh, Nicola, Elbana, Husam, Gandavaram, Srikanth, Cash, Thomas, Jayatilaka, Lara, Rourke, Harry, Finnie, Stephanie, Studnicka, Katarzyna, Holmes, David, Caruana, Ethan, Oputa, Tobi, Bux, Mohammed, McLauchlan, George, Stirling, Scott, Hoggett, Lee, Peake, Chris, Duke, Kathryn, Rossiter, Daniel, Torku, David, Solan, Matthew, Anibueze, Chukwudubem, To, Christopher, Manafa, Chibuzo, Gyimah, Dominic Ayi, Fagg, James, Duggleby, Luke, Sgardelis, Panagiotis, Stanger, Sophie, Barton, Tristan, Al-Sukaini, Ahmad, Venkatesan, Mohanraj, McKerron, Sally, Balasubramanian, Sathishkumar, Koç, Togay, Dean, Mike, Abdelaziz, Ahmed, Toh, Eugene, Stevenson, Robert Allen, Naqvi, Ali Zain, Balai, Edward, Little, Max, Pearse, Michael, Sait, Saif, Drysdale, Henry, Lowdon, Hamish, Rahim, Sybghat, Fennelly, Joseph, Davda, Kinner, Solari, Francesca, Hill, Daniel, Hanger, Joseph, Anderson, Kerry, Jones, Robin, Dutta, Agneish, Sayani, Junaid, Yeoh, Tien, Crate, Georgina, Forder, Justin, Bikkannavar, Pratik, Erotocritou, Marios, Relwani, Jiten, Singh, Saumya, Sinha, Rachel, Stringfellow, Thomas, Eves, Joshua, Asher, Dipika, Jones, Alyssa, Ali, Karar, Rajendran, Kausala, Cadwallader, Craig, Gray, Matt, Mani, Ravi, Ebreo, Darren, Mahoney, Rachel, Latif, Javed, Baid, Roshni, Charalambides, Maria, Khatri, Khushboo, Zafeiris, Konstantinos, Charalambides, Charalambos, Taylor, Isabel, Qulaghassi, Mahdi, Onubogu, Ifeanyi Kem, Oliver, Matthew, Manning, Christopher, Williams, James, Cheyne, Natalie, Pillai, Anand, Fennelly, Joseph T., Gourbault, Lysander J., Price, Michael J., and Ward, Alex E.

Published
2021
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6. Weight-bearing in ankle fractures: An audit of UK practice

Author

Gill, James R., Lostis, Emilie, Bleibleh, Sabri S., Hennessy, Michael S., Thondickal, Femi, Gadd, Richard J., Grupping, Rachael, Chikate, Albert, Khor, Suan, Malani, Sangam, Nabulyato, William, Rai, Praveen, Vaghela, Kalpesh R., Pillai, Shashank, Baskaran, Dinnish, Kugapiriyan, Raviraj, Masunda, Stanley, Parker, Jeremy, Bintcliffe, Fiona, Murphy, Tom, Rose, Barry, Shafafy, Roozbeh, Holme, Thomas, Mahapatra, Piyush, Mallina, Ravikanth, Mansouri, Reza, Render, Luke, Scrimshire, Ashley, Walker, Lucy, Ahmed, Syed, Kandel, Poonam, Drake, Benjamin, Williams, Patrick, Hannah, Andrew, Hayat, Zara, Aitken, Thomas, Carter, Thomas H., Crome, Christopher, Banerjee, Purnajyoti, Ravi, Vinoth, West, Victor, Bennett, James, Leung, Andraay, Skipsey, David, Blomfield, Mark, Akhtar, Ahsan, Al-Dadah, Khalid, Davies, Emma, Kropelnicki, Anna, Leong, Edmund, Malik, Sheraz, Sun, Stephen Ng Man, D'Souza, Winster, Mehmood, Shahid, Reynolds, Gavin, Sattar, Mariam, Abdelhaq, Ady, Durst, Alexander, Ngu, Albert, Budacan, Alina, Gray, Matt, Myatt, Antonia, Claireaux, Henry A., Griffin, Xavier L., Nagra, Navraj S., Rashid, Mustafa, Borse, Vishal, Muir, Ross, Alho, Roberto J.R., Ankers, Thomas, Aziz, Sheweidin, Perianayagam, Ganapathy, Al-Dulaimy, Bakir, Franklin, Marieta, Wilson, Purwa, Chandrappa, Mallikarjun, Mubasher, Latif, Shahid, Rizwan, Shashidhara, Singapura, Xu, Yiteng, Hodhody, Ghazal, Jeffery, John, Humphry, Simon, Street, Julia, Yasin, Tariq, Kaur, Jasprit, Donovan, Richard L., Kahane, Steve, Parker, Lee, Byrne, Hayleigh, Gowda, Sushmith, Frank, Barbara, Shenoy, Ravikiran, Singh, Abhinav, Trakru, Sunil, Brewer, Paul, Petrie, Mike, Bhattee, Ghias, Rafferty, Michael, Tang, Quen O., Elbashir, Mohamed, Kutuzov, Vladislav, Spacey, Kate, Ebreo, Darren, Gupta, Shreekant, Ahmed, Usman, Mustafa, Mohammed Al, Ali, Seyed, Chauhan, Govind Singh S., Elashry, Saad, Lotfi, Naeil, Malik, Shahbaz, Marsh, Alastair, Pagkalos, Iosif, Rangan, Raghunaathan, Raval, Parag, Sarhan, Islam, Shaik, Yousufuddin, Thangaraj, Rajkumar, Wu, Feiran, Kazmi, Zainab, Kong, Chia Yew Y., Lebe, Moritz, Lidder, Surjit, Masterson, Sean, Shabani, Farzad, Ikram, Adeel, Marson, Ben A., Matthews, Paul, Prasad, Ganesh, Davenport, James, Karski, Mike, Syam, Kevin, Unnikrishnan, Nithin, Abu-Rajab, Rashid, Liew, Ignatius, Koh, Niak Puei, Barrie, Jim, Goubran, Alex, Maling, Lucy, Karam, Edward, Limb, Richard, Matheron, George, Awad, Fady, Shuttlewood, Kimberely, Pearce, Jack, Teoh, Kar H., Higgins, Jo, Koc, Togay, Mcfall, John, Holland, George, Maempel, Julian F., Nicholson, Jamie, Wickramasinghe, Neil, Berg, Andrew J., Knowles, David, Dowlut, Naeem, Hayat, Mehvish, Bourne, James T., Dupley, Leanne, Kim, Min Soo S.K., Poustie, Mark, Bowen, Laura, Fawdington, Ross A., Moulton, Lawrence S, Ribee, Helen, Tunstall, Charlotte, Boyd, Robert, Quayle, Jonathan, Auld, Felicity, Bellringer, Simon F, Cassidy, Lucy, Ray, Arunray, Rogers, Benedict, Kapur, Richard, Kyprianou, Katerina, Tarassoli, Payam, Ferns, John, Killen, Maire-Clare, Sur, Hartej, Tam, Yin, Bala, Sathish, Das, Rishi, Higgin, Ryan, Topping, Jonathan, Duffy, Sean, Robinson, Peter, Stoddart, Mike, AlTaweel, Ali, Chew, Ernest, Popat, Ravi, Sharma, Aadhar, Wharton, Rupert, Hook, Samantha, Khangura, Taran, Seewoonarain, Sheena, Sokota, Sian, Cross, Charlotte E, Mcloughlin, Kathryn, Andrews, Frances, Bretherton, Chris P, Simpson, Jennie, Lupu, Andreea, Thomas, Charlotte T, Tweedie, Blair, Chirputka, Kedar, Ferns, Bernard, Ross, Steven, Zhang, Yuhao, Goodland, Christopher, Barkham, Benjamin, Bhamra, Jagmeet, Cuthbert, Rory, Nair, Arun, Payne, Robert, Weston, Matthew, Wong, Ryan, Wood, Tom, Thomas, Philip, Wilkinson, Hannah, Adeelakhtar, Muhammad, Bate, Jo-Ann, Brandao, Bernardo Duarte, Lovell, Martin, Unsworth, Richard, Clayton, Robert, Yapp, Liam, Badgetu, Ravi, Hughes, Mike, Burns, Sophia, Kho, Ling, Li, Lily, Evans, Douglas, Fenner, Christopher, Logishetty, Kartik, Nahas, Sam, Nathan, Subra, Kumar, Karadi, Negus, Oliver, Salt, Gemma, Sarker, Shahrier, Blucher, Nicola, Lyle, Shirley, Buckle, Christopher, Chibuzo, Manafa, Jones, Mark, Nachev, Krasimir, Sayani, Junaid, Williams, Olatoyosi, Cruickshank, James, and Edwards, Nicholas

Published
2019
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8. Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial.

Author

Lee, Matthew M.Y., Petrie, Mark C., Cleland, John G.F., Donnelly, Patrick, Francis, Mark, Hannah, Andrew, Japp, Alan G., Labinjoh, Catherine, Lang, Ninian N., Manisty, Charlotte, Petrie, Colin J., Piper, Susan E., Williams, Simon G., Ford, Ian, and Kalra, Paul R.

Subjects
HEART failure patients, SYSTOLIC blood pressure, ANGIOTENSIN-receptor blockers, ACE inhibitors, ACUTE coronary syndrome, HEART failure
Published
2024
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9. Impaired Cardiac and Skeletal Muscle Energetics Following Anthracycline Therapy for Breast Cancer.

Author

Gamble, David T., Ross, James, Khan, Hilal, Unger, Andreas, Cheyne, Lesley, Rudd, Amelia, Saunders, Fiona, Srivanasan, Janaki, Kamya, Sylvia, Horgan, Graham, Hannah, Andrew, Baliga, Santosh, Tocchetti, Carlo Gabriele, Urquhart, Gordon, Linke, Wolfgang A., Masannat, Yazan, Mustafa, Ahmed, Fuller, Mairi, Elsberger, Beatrix, and Sharma, Ravi

Abstract

BACKGROUND: Anthracycline-related cardiac toxicity is a recognized consequence of cancer therapies. We assess resting cardiac and skeletal muscle energetics and myocyte, sarcomere, and mitochondrial integrity in patients with breast cancer receiving epirubicin. METHODS: In a prospective, mechanistic, observational, longitudinal study, we investigated chemotherapy-naive patients with breast cancer receiving epirubicin versus sex- and age-matched healthy controls. Resting energetic status of cardiac and skeletal muscle (phosphocreatine/gamma ATP and inorganic phosphate [Pi]/phosphocreatine, respectively) was assessed with 31P-magnetic resonance spectroscopy. Cardiac function and tissue characterization (magnetic resonance imaging and 2D-echocardiography), cardiac biomarkers (serum NT-pro-BNP and high-sensitivity troponin I), and structural assessments of skeletal muscle biopsies were obtained. All study assessments were performed before and after chemotherapy. RESULTS: Twenty-five female patients with breast cancer (median age, 53 years) received a mean epirubicin dose of 304 mg/ m², and 25 age/sex-matched controls were recruited. Despite comparable baseline cardiac and skeletal muscle energetics with the healthy controls, after chemotherapy, patients with breast cancer showed a reduction in cardiac phosphocreatine/ gamma ATP ratio (2.0±0.7 versus 1.1±0.5; P=0.001) and an increase in skeletal muscle Pi/phosphocreatine ratio (0.1±0.1 versus 0.2±0.1; P=0.022). This occurred in the context of increases in left ventricular end-systolic and end-diastolic volumes (P=0.009 and P=0.008, respectively), T1 and T2 mapping (P=0.001 and P=0.028, respectively) but with preserved left ventricular ejection fraction, mass and global longitudinal strain, and no change in cardiac biomarkers. There was preservation of the mitochondrial copy number in skeletal muscle biopsies but a significant increase in areas of skeletal muscle degradation (P=0.001) in patients with breast cancer following chemotherapy. Patients with breast cancer demonstrated a reduction in skeletal muscle sarcomere number from the prechemotherapy stage compared with healthy controls (P=0.013). CONCLUSIONS: Contemporary doses of epirubicin for breast cancer treatment result in a significant reduction of cardiac and skeletal muscle high-energy 31P-metabolism alongside structural skeletal muscle changes. [ABSTRACT FROM AUTHOR]

Published
2023
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10. Electronic Transcripts: Past, Present, and Future

Author

Harris, Sarah, Hannah, Andrew, and Stones, Dave

Abstract

Electronic transcripts are no longer a concept awaiting definition. They are here to stay. Although paper transcripts remain the standard--at least in terms of volume--an ever-increasing number and eventual majority of students and alumni will expect if not require electronic transcripts. College registrars and admissions officers' obligation to maintain the accuracy and security of transcripts is obvious, absolute, and permanent. Electronic transcripts are just the latest in a long line of technological advances that registrars have embraced at first with caution but then with open arms. Delivery of paper transcripts by postal or even expedited services is coming to be considered too slow. Over the last two decades, and particularly during the last eight years, a small but effective set of electronic delivery methods has emerged that supports registrars' transmitting of transcripts. In most cases, the delivery method determines the medium in which the transcript is to be produced (or vice versa). This article describes electronic technologies currently used by registrars for the production of official transcripts. It focuses on EDI, XML and pdf transcript production and delivery methods in postsecondary education, including for transfer student and graduate and professional school admissions. (Contains 2 footnotes.)

Published
2011

12. Fractional flow reserve vs. angiography in guiding management to optimize outcomes in non-ST-segment elevation myocardial infarction: the British Heart Foundation FAMOUS–NSTEMI randomized trial

Author

Layland, Jamie, Oldroyd, Keith G., Curzen, Nick, Sood, Arvind, Balachandran, Kanarath, Das, Raj, Junejo, Shahid, Ahmed, Nadeem, Lee, Matthew M.Y., Shaukat, Aadil, OʼDonnell, Anna, Nam, Julian, Briggs, Andrew, Henderson, Robert, McConnachie, Alex, Berry, Colin, Hannah, Andrew, Stewart, Andrew, Metcalfe, Malcolm, Norrie, John, Chowdhary, Saqib, Clark, Andrew, Henderson, Robert, Balachandran, Kanarath, Berry, Colin, Baird, Gordon, OʼDonnell, Anna, Sood, Arvind, Curzen, Nick, Das, Raj, Ford, Ian, Layland, Jamie, Junejo, Shahid, and Oldroyd, Keith

Published
2015
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14. Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)

Author

Siddiqi, Nishat, Neil, Christopher, Bruce, Margaret, MacLennan, Graeme, Cotton, Seonaidh, Papadopoulou, Sofia, Feelisch, Martin, Bunce, Nicholas, Lim, Pitt O., Hildick-Smith, David, Horowitz, John, Madhani, Melanie, Boon, Nicholas, Dawson, Dana, Kaski, Juan Carlos, Frenneaux, Michael, Siddiqi, Nishat, Neil, Christopher, Bruce, Margaret, MacLennan, Graeme, Cotton, Seonaidh, Dawson, Dana, Frenneaux, Michael, Singh, Satnam, Schwarz, Konstantin, Jagpal, Baljit, Metcalfe, Malcolm, Stewart, Andrew, Hannah, Andrew, Awsan, Noman, Broadhurst, Paul, Hogg, Duncan, Garg, Deepak, Slattery, Elaine, Davidson, Tracey, McDonald, Alison, McPherson, Gladys, Kaski, Juan-Carlos, Lim, Pitt O, Brown, Sue, Papadopoulou, Sofia A, Gonzalvez, Fatima, Roy, David, Firoozi, Sami, Bogle, Richard, Roberts, Elved, Rhodes, Jonathan, Hildick-Smith, David, de Belder, Adam, Cooter, Nina, Bennett, Lorraine, Horowitz, John, Rajendran, Sharmalar, Dautov, Rustem, Black, Marilyn, Jansen, Else, Boon, Nicholas, Struthers, Allan, Toff, William, Dargie, Henry, Lang, Chim, and Nightingale, Peter

Published
2014
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15. Tsar Vladimir I?

Author

Hannah, Andrew

Subjects
Russia -- History, Communism -- Russia, History
Abstract

Lenin's regime in Russia between 1917 and 1924 is discussed, with particular attention given to Lenin's political strategies and economic policy. Lenin's implementation of a party dictatorship is analysed and compared with the tsarist regime which preceded Lenin., How successful was Lenin's leadership after the October Revolution? The Russian October Revolution was a coup d'etat carried out by an armed minority. On the night of 24-25 October 1917 [...]

Published
2001

17. Peter Stolypin: the Tsar's last hope?

Author

Hannah, Andrew

Subjects
Russia -- History, History
Abstract

Russian Statesman Peter Stolypin offered Tsar Nicholas II a plan to reform the country but after some initial success he became under suspicion from the Tsar and the Duma. He was murdered in 1911. Stolypin encouraged the weakening of the commune system and increased private ownership of land in his 1906 agriculture policy. He also wanted to introduce compulsory education and reform the local authorities. Stolypin tried to work with the Duma and the Tsar. As Chairman of the Council of Ministers he changed the franchise laws to the third Duma in 1907 to make it less confrontational.

Published
1998

23. Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST segment elevation myocardial infarction (FAMOUS-NSTEMI) developmental trial: cost-effectiveness using a mixed trial-and model-based methods.

Author

Nam, Julian, Briggs, Andrew, Layland, Jamie, Oldroyd, Keith G., Curzen, Nick, Sood, Arvind, Balachandran, Kanarath, Das, Raj, Junejo, Shahid, Eteiba, Hany, Petrie, Mark C., Lindsay, Mitchell, Watkins, Stuart, Corbett, Simon, O'Rourke, Brian, O'Donnell, Anna, Stewart, Andrew, Hannah, Andrew, McConnachie, Alex, and Henderson, Robert

Abstract

Background: In the Fractional flow reserve (FFR) versus angiography in guiding management to optimise outcomes in non-ST elevation myocardial infarction (FAMOUS) clinical trial, FFR was shown to significantly reduce coronary revascularisation, compared to visual interpretation of standard coronary angiography without FFR. We estimated the cost-effectiveness from a UK National Health Service perspective, based on the results of FAMOUS. Methods: A mixed trial- and model-based approach using decision and statistical modelling was used. Within-trial (1 -year) costs and QALYs were assembled at the individual level and then modelled on subsequent management strategy [coronary artery bypass graft (CABG), percutaneous coronary intervention (PCI) or medical therapy (MT)] and major adverse coronary events (death, Ml, stroke and revascularisation). One-year resource uses included: material, hospitalisation, medical, health professional service use and events. Utilities were derived from individual EQ5D responses. Unit costs were derived from the literature. Outcomes were extended to a lifetime on the basis of MACE during the 1st year. Costs and QALYs were modelled using generalized linear models whilst MACE was modelled using logistic regression. The analysis adopted a payer perspective. Costs and outcomes were discounted at 3.5 %. Results: Costs were related to the subsequent management strategy and MACE whilst QALYs were not. FFR led to a modest cost increase, albeit an imprecise increase, over both the trial [£112 (--£129 to £357)] and lifetime horizons [£133 (-£199 to £499)]. FFR led to a small, albeit imprecise, increase in QALYs over both the trial [0.02 (-0.03 to 0.06)] and lifetime horizons [0.03 (-0.21 to 0.28)]. The mean ICER was £7516/QALY and £4290/QALY over the trial and lifetime horizons, respectively. Decision remained high; FFR had 64 and 59 % probability of cost-effectiveness over trial and lifetime horizons, respectively. Conclusions: FFR was cost-effective at the mean, albeit with considerable decision uncertainty. Uncertainty can be reduced with more information on long-term health events. [ABSTRACT FROM AUTHOR]

Published
2015
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24. Evolution of Allometry in Antirrhinum.

Author

Xianzhong Feng, Wilson, Yvette, Bowers, Jennifer, Kennaway, Richard, Bangham, Andrew, Hannah, Andrew, Coen, Enrico, and Hudson, Andrew

Subjects
ALLOMETRY in plants, SNAPDRAGONS, PLANT diversity, GENES, LEAVES
Abstract

Correlated variation in shape and size (allometry) is a major component of natural diversity. We examined the evolutionary and genetic basis for allometry using leaves and flower petals of snapdragon species (Antirrhinum). A computational method was developed to capture shape and size variation in both types of organ within the Antirrhinum species group. The results show that the major component of variation between species involves positively correlated changes in leaf and petal size. The correlation was maintained in an F2 population derived from crossing two species with organs of different sizes, suggesting that developmental constraints were involved. Identification of the underlying genes as quantitative trait loci revealed that the larger species carried alleles that increased organ size at all loci. Although this was initially taken as evidence that directional selection has driven diversity in both leaf and petal size, simulations revealed that evolution without consistent directional selection, an undirected walk, could also account for the parental distribution of organ size alleles. [ABSTRACT FROM AUTHOR]

Published
2009
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25. Food-the way to a man's heart: A mini-case series of Campylobacter perimyocarditis.

Author

Turpie, David F. S., Forbes, Ken J., Hannah, Andrew, Metcalfe, Malcolm J., Mckenzie, Hamish, and Small, Gary R.

Subjects
CAMPYLOBACTER jejuni, INTESTINAL disease treatment, GASTROENTERITIS, FOOD poisoning, ABDOMINAL pain, DIARRHEA, OMEPRAZOLE, CIPROFLOXACIN, PATIENTS, THERAPEUTICS
Abstract

Campylobacter jejuni enteritis is 1 of the most common causes of food poisoning. Although an infrequent complication, Campylobacter associated perimyocarditis can have fatal consequences. This article illustrates 2 cases. We examine the types of Campylobacter jejuni responsible and report the observed male preponderance of this complication. [ABSTRACT FROM AUTHOR]

Published
2009
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28. Comparison of sample types for N-terminal pro-B-type natriuretic peptide measured on the Siemens Immulite 2500 and Dimension Vista LOCI methods.

Author

Peake, Roy W. A., Turner, Helen E., Leaper, Wendy, Deans, Kevin A., Hannah, Andrew, and Croal, Bernard L.

Subjects
NATRIURETIC peptides, HEART failure, SERUM, CARDIOLOGY, HEART diseases
Abstract

Background: Measurement of serum natriuretic peptides is recommended in patients with suspected heart failure. Assays for N-terminal pro-B-type natriuretic peptide (NT-proBNP) are available on several platforms and can be measured in serum or heparinized plasma. Siemens Healthcare Diagnostics do not recommend the use of serum for the Immulite NT-proBNP assay. Serum offers some practical advantages over plasma. We investigated the suitability of serum for use with the Immulite and Dimension Vista LOCI methods. Methods: Paired serum and heparinized plasma samples were drawn from patients in the Cardiology Department over a 48-h period. Samples spanning the NT-proBNP concentration range 50-60,000 ng/L were analysed using the Siemens Immulite 2500 and Dimension Vista LOCI methods. Results: There was no significant difference between serum NT-proBNP concentrations on either platform (P = 0.0665). Plasma NT-proBNP measured using the Immulite were moderately higher than on Vista (P< 0.0001). There was a small but statistically significant difference between plasma and serum NT-proBNP measured using the Immulite (P = 0.0002) with plasma values higher than serum. A similar comparison between plasma and serum NT-proBNP measured using the Vista showed no difference (P = 0.3662). Conclusions: We have demonstrated the suitability of serum for use on the Immulite 2500. Bland-Altman comparative analysis indicated minimal bias between both serum methods near the clinical cut-off level below which heart failure is considered unlikely (400 ng/L) up to the highest concentration tested (60,000 ng/L). [ABSTRACT FROM AUTHOR]

Published
2012
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29. Effect of correcting iron deficiency on the risk of serious infection in heart failure: Insights from the IRONMAN trial.

Author

Foley, Paul W., Kalra, Paul R., Cleland, John G.F., Petrie, Mark C., Kalra, Philip A., Squire, Ian, Campbell, Philip, Chapman, Callum, Donnelly, Patrick, Graham, Fraser, Hannah, Andrew, Lang, Ninian N., Matthews, Iain, Leslie, Stephen J., Pellicori, Pierpaolo, Piper, Sue, Ray, Robin, Savage, Hernry O., Spencer, Chales, and Walsh, John

Subjects
*IRON deficiency, *VENTRICULAR ejection fraction, *HEART failure patients, *HEART failure, *TRANSFERRIN
Abstract

Aims Methods and results Conclusions Concerns exist that intravenous (IV) iron might increase the risk of infections. The IRONMAN trial provided an opportunity to investigate whether giving IV ferric derisomaltose (FDI) to patients with heart failure and iron deficiency alters the rate of hospitalization or death due to infections.IRONMAN was a randomized trial of IV FDI versus usual care in patients with symptomatic heart failure, left ventricular ejection fraction (LVEF) ≤45%, and transferrin saturation (TSAT) <20% or ferritin <100 μg/L. Infection was a pre‐specified, blindly‐adjudicated, safety endpoint. The primary analysis of interest was infection as the main reason for hospitalization or death, using first and recurrent events analyses. The composite primary event of interest tended to be lower in those randomized to FDI when analysed as first (hazard ratio [HR] 0.79, 95% confidence interval [CI] 0.62–1.01, p = 0.055) or recurrent event (rate ratio 0.85, 95% CI 0.64–1.13, p = 0.089). The composite results were driven by fewer hospitalizations for infection (HR 0.76, 95% CI 0.49–0.98, p = 0.032), with 5% fewer patients (absolute reduction) experiencing such an event if assigned to FDI. Similar trends were observed for recurrent events (HR 0.82, 95% CI 0.62–1.10). Further analyses suggested that the reduction in hospitalizations due to infection with FDI was restricted to patients with TSAT <20%.In patients with heart failure and a reduced LVEF, correction of iron deficiency is not associated with an increased risk of hospitalization or death from infection, and may reduce such events, especially when TSAT is <20%.Clinical Trial Registration: ClinicalTrials.gov, NCT02642562. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Dental occlusion and temporomandibular disorders.

Author

Stone, J Caitlin, Hannah, Andrew, and Nagar, Nathan

Subjects
DENTAL occlusion, TEMPOROMANDIBULAR disorders, DENTAL research, DENTISTRY, ORAL medicine
Abstract

Data sourcesMedline, Scopus and Google Scholar.Study selectionTwo reviewers selected studies independently. English language clinical studies assessing the association between temporomandibular disorders (TMD) and features of dental occlusion were considered.Data extraction and synthesisStudy quality was assessed based on the Newcastle-Ottawa Scale (NOS) and a narrative synthesis was presented.ResultsIn all 25 studies (17 case-control, eight comparative) were included. Overall there was a high variability between occlusal features and TMD diagnosis. Findings were consistent with a lack of clinically relevant association between TMD and dental occlusion. Only two studies were associated with TMD in the majority (≥50%) of single variable analyses in patient populations. Only mediotrusive interferences are associated with TMD in the majority of multiple variable analyses.ConclusionsThe findings support the absence of a disease-specific association, there is no ground to hypothesise a major role for dental occlusion in the pathophysiology of TMDs. Dental clinicians are thus encouraged to move forward and abandon the old-fashioned gnathological paradig [ABSTRACT FROM AUTHOR]

Published
2017
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31. DECISION MAKING USING FRACTIONAL FLOW RESERVE IS ASSOCIATED WITH LOWER RATES OF INCOMPLETE REVASCULARIZATION COMPARED WITH ANGIOGRAPHIC GUIDED DECISION MAKING AMONGST PATIENTS WITH NSTEMI.

Author

Layland, Jamie John, Carberry, Jaclyn, May, Vanessa T.Y., Lee, Matthew, Eteiba, Hany, Lindsay, Mitchell, Petrie, Mark, McEntegart, Margaret, Watkins, Stuart, Shaukat, Aadil, Oldroyd, Keith, Curzen, Nick, Sood, Arvind, Balachandran, Kanarath, Das, Rajiv, Junejo, Shahid, Hannah, Andrew, Stewart, Andrew, Henderson, Robert, and McConnachie, Alex

Subjects
*PATIENT decision making, *DECISION making, *RATES
Published
2017
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32. Right ventricular septal pacing as alternative for failed left ventricular lead implantation in cardiac resynchronization therapy candidates.

Author

Alhous MH, Small GR, Hannah A, Hillis GS, Frenneaux M, and Broadhurst PA

Subjects
Aged, Cardiac Resynchronization Therapy Devices, Female, Heart Failure complications, Heart Failure diagnosis, Humans, Male, Reoperation methods, Treatment Failure, Treatment Outcome, Ventricular Dysfunction, Left diagnosis, Ventricular Dysfunction, Left etiology, Cardiac Resynchronization Therapy methods, Electrodes, Implanted, Heart Failure therapy, Heart Septum surgery, Heart Ventricles surgery, Prosthesis Implantation methods, Ventricular Dysfunction, Left prevention & control
Abstract

Aims: To compare the effects on left ventricular (LV) function of right ventricular (RV) septal pacing vs. cardiac resynchronization therapy (CRT) in patients with an indication for the latter. Cardiac resynchronization therapy is an effective therapy in patients with drug-refractory heart failure. Despite advances in implantation techniques, LV lead placement can be impossible in up to 10% of cases. We, therefore, assessed the effects of RV septal pacing from mid septum (RVmIVS) and outflow tract (RVOT) on cardiac performance, in comparison with CRT., Methods and Results: Twenty-two patients scheduled for CRT underwent dual-chamber temporary pacing. The ventricular lead was placed at the RV apex (RVA), RVmIVS, and RVOT in random order. Comprehensive echocardiography was performed in a baseline AAI mode and then at each RV position in dual chamber pacemaker function (D pacing, D sensing, D dual responses) mode and repeated on the next day following CRT implantation. Right ventricular apex pacing did not change any of the assessed echocardiography parameters. Both RVmIVS and RVOT pacing increased LV ejection fraction (EF): 29 ± 7% at baseline vs. 32 ± 6% (P = 0.02) and 32 ± 5% (P = 0.04) with RVmIVS and RVOT pacing, respectively. Similarly, the dyssynchrony index (Ts-SD) decreased: 50 ± 19 ms at baseline vs. 39 ± 17 ms (P = 0.04) and 37 ± 17 ms (P = 0.006) with RVmIVS and RVOT pacing, respectively. Cardiac resynchronization therapy further improved LVEF and Ts-SD to 36 ± 7% and 34 ± 15 ms, respectively, however, only LVEF was significantly higher compared with RVmIVS and RVOT pacing (P = 0.03 and P = 0.01 respectively). There were no significant differences in either LVEF or Ts-SD between RVmIVS and RVOT., Conclusion: Right ventricular septal pacing from mid septum or RVOT pacing improves LVEF and LV synchrony in CRT candidates. Further improvement in LVEF was achieved by CRT, which remains the 'gold standard' therapy in these patients. However, RV septal pacing is worthy of further study as an alternative strategy when LV lead implantation fails., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)

Published
2015
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