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PurposeCraniospinal irradiation (CSI) using tomotherapy has advantages over standard 3-dimensional techniques. However, there is a paucity of published data on craniospinal setup reproducibility to guide appropriate planning treatment volume (PTV) margins. We sought to evaluate the setup accuracy of patients undergoing CSI to optimize PTV margins.Methods and materialsWe measured residual setup deviation between simulation computed tomography (CT) and daily megavoltage CT after couch shifts made by therapists after megavoltage CT-based image registration for 10 patients who completed CSI at our institution. Translational displacement values were recorded at the sella, top of T1, and top of L5 in the anteroposterior (AP) and lateral planes. Systematic and random error were calculated from displacement values. Using z score analysis, we calculated minimal PTV margins to encompass 90% of recorded fractions at each level. We evaluated whether patient characteristics predict for increased setup error using standard statistical techniques.ResultsThe mean setup deviation in the AP plane across all treatments was 2.49, 3.40, and 3.83 mm at the sella, T1, and L5, respectively. Mean lateral setup error was 2.86, 4.02, and 5.46 mm at the sella, T1, and L5, respectively. Systematic error ranged from 0.75 to 1.01 mm at the sella, 1.09 to 1.37 mm at T1, and 1.30 to 1.50 mm at L5. Random error ranged from 1.35 to 1.41 mm at the sella, 1.48 to 1.73 mm at T1, and 2.26 to 2.37 mm at L5. The minimum margin to cover 90% of the treatments was 6.4, 8.2, and 10.5 mm at the sella, T1, and L5, respectively. There appeared to be a correlation between older age and lateral setup error in the L spine approaching statistical significance (R, 0.629; P = .052).ConclusionsSetup error increases in the caudal direction of the spine and is greater in the lateral plane compared with the AP plane. We recommend a PTV margin of 5 to 7 mm in the brain and 10 mm in the spine.

In this paper, a wide-band, low-profile antenna is presented for a high-integration phased array system. The proposed antenna, implemented using a tightly coupled array, operates over roughly the X-K frequency band and is performant at 8 GHz–18.5 GHz. The antenna can scan to ± 60 degrees in both the E- and H-planes. Compared to previous tightly coupled antennas with smaller element spacing, the antenna in this paper reaches 9.4 mm, which corresponds to 0.58   λ of high frequency, suitable for engineering application conditions in production. The antenna can be soldered to BGA T/R chips in this space. Additionally, to facilitate flexible assembly for large arrays, the antenna is manufactured modularly using four elements and its parasitic radiation is analyzed. Then, a method for repressing parasitic radiation is presented. Finally, the antenna is fabricated and measured in a microwave chamber, exhibiting an excellent pattern and scanning radiation. The measured performance agrees with the full-wave finite array simulations. [ABSTRACT FROM AUTHOR]

This study investigated the effect of sustained loading on the cumulative damage of a newly developed smart cement-based self-healing composite material (SMA-ECC). SMA-ECC is composed of engineered cementitious composite (ECC) and shape memory alloy (SMA) fibers. A uniaxial compressive test with five predefined loading levels (0%, 30%, 40%, 50%, and 60% of compressive strength) was conducted on SMA-ECC hollow-cylindrical specimens and ECC control hollow-cylindrical specimens. The cumulative damage was mainly determined by changes in the total water absorption of different groups of specimens during three different periods (not loaded, at a predefined loading level, and after unloading). A normalized water content index was proposed to couple the effects of self-healing, sustained loading, and cumulative damage. The test results indicate that the cumulative water absorption of SMA-ECC was 35% lower than that of ECC, which may indicate less irreparable damage. In addition, the self-healing ability of SMA-ECC specimens under different compression load levels was evaluated through normalized water content analysis. SMA-ECC exhibited a 100% repair rate at load levels of 30% and 40%. At a higher load level of 60%, the repair rate of SMA-ECC was 76%. These results collectively emphasize the significant impermeability and self-healing performance of SMA-ECC after unloading. [ABSTRACT FROM AUTHOR]

Background: The RefleXion X1 is a novel radiotherapy delivery system on a ring gantry equipped with fan‐beam kV‐CT and PET imaging subsystems. The day‐to‐day scanning variability of radiomics features must be evaluated before any attempt to utilize radiomics features. Purpose: This study aims to characterize the repeatability and reproducibility of radiomic features produced by the RefleXion X1 kV‐CT. Materials and Methods: The Credence Cartridge Radiomics (CCR) phantom includes six cartridges of varied materials. It was scanned 10 times on the RefleXion X1 kVCT imaging subsystem over a 3‐month period using the two most frequently used scanning protocols (BMS and BMF). Fifty‐five radiomic features were extracted for each ROI on each CT scan and analyzed using LifeX software. The coefficient of variation (COV) was computed to evaluate the repeatability. Intraclass correlation coefficient (ICC) and concordance correlation coefficient (CCC) were used to evaluate the repeatability and reproducibility of the scanned images using 0.9 as the threshold. This process is repeated on a GE PET‐CT scanner using several built‐in protocols as a comparison. Results: On average, 87% of the features on both scan protocols on the RefleXion X1 kVCT imaging subsystem can be considered repeatable as they met COV < 10% criteria. On GE PET‐CT, this number is similar at 86%. When we tighten the criteria to COV <5%, the RefleXion X1 kVCT imaging subsystem showed much better repeatability with 81% of features on average whereas GE PET‐CT showed only 73.5% on average. About 91% and 89% of the features with ICC > 0.9 respectively for BMS and BMF protocols on RefleXion X1. On the other hand, the percentage of features with ICC > 0.9 on GE PET‐CT ranges from 67% to 82%. The RefleXion X1 kVCT imaging subsystem showed excellent intra‐scanner reproducibility between the scanning protocols much better than the GE PET CT scanner. For the inter‐scanner reproducibility, the percentage of features with CCC > 0.9 ranged from 49% to 80%. between X1 and GE PET‐CT scanning protocols. Conclusions: Clinically useful CT radiomic features produced by the RefleXion X1 kVCT imaging subsystem are reproducible and stable over time, demonstrating its utility as a quantitative imaging platform. [ABSTRACT FROM AUTHOR]

Unbalanced and inadequate development has led to challenges such as resource shortage, ecological fragility, and economic backwardness in the water-receiving area of Henan Province, which has hindered the high-quality development of the region. This research aims to construct a high-quality development regulation model. The single-indicator quantification–multi-indicator synthesis–multicriteria integration (SMI-P) method was used to evaluate the level of regional development; using the method of embedded system dynamics, the regulation model was constructed and applied. The results show that (1) from 2011 to 2020, the degree of regional high-quality development showed an increasing trend, rising from a low level (0.34) to a medium level (0.57), an increase of one level, but the level of high-quality development still has a lot of room for improvement and faces great challenges; (2) the development of a resource–ecology–economy–social system was in a state of non-harmonious balance, and the proportion of contributions of each system was very different, but the system was developing towards a state of harmony and balance; (3) based on the constructed high-quality development regulation model, the key constraints affecting the high-quality development of the Yellow River water supply area in Henan Province are per capita water consumption, per capita energy consumption, carbon emissions per capita, GDP per capita, etc. The model constructed in this paper can improve the quality development level through the application of examples. The high-quality development degree of the study area was increased from 0.57 to 0.8. [ABSTRACT FROM AUTHOR]

Purpose: TMI utilizes IMRT to deliver organ sparing targeted radiotherapy in patients undergoing hematopoietic cell transplantation (HCT). TMI addresses an unmet need, specifically patients with refractory or relapsed (R/R) hematologic malignancies who have poor outcomes with standard HCT regimens and where attempts to improve outcomes by adding or dose escalating TBI are not possible due to increased toxicities. Over 500 patients have received TMI at this center. This review summarizes this experience including planning and delivery, clinical results, and future directions. Methods: Patients were treated on prospective allogeneic HCT trials using helical tomographic or VMAT IMRT delivery. Target structures included the bone/marrow only (TMI), or the addition of lymph nodes, and spleen (total marrow and lymphoid irradiation, TMLI). Total dose ranged from 12 to 20 Gy at 1.5-2.0 Gy fractions twice daily. Results: Trials demonstrate engraftment in all patients and a low incidence of radiation related toxicities and extramedullary relapses. In R/R acute leukemia TMLI 20 Gy, etoposide, and cyclophosphamide (Cy) results in a 1-year non- relapse mortality (NRM) rate of 6% and 2-year overall survival (OS) of 48%; TMLI 12 Gy added to fludarabine (flu) and melphalan (mel) in older patients (≥ 60 years old) results in a NRM rate of 33% comparable to flu/mel alone, and 5-year OS of 42%; and TMLI 20 Gy/flu/Cy and post-transplant Cy (PTCy) in haplo- identical HCT results in a 2-year NRM rate of 13% and 1-year OS of 83%. In AML in complete remission, TMLI 20 Gy and PTCy results in 2-year NRM, OS, and GVHD free/relapse-free survival (GRFS) rates of 0%, 86•7%, and 59.3%, respectively. Conclusion: TMI/TMLI shows significant promise, low NRM rates, the ability to offer myeloablative radiation containing regimens to older patients, the ability to dose escalate, and response and survival rates that compare favorably to published results. Collaboration between radiation oncology and hematology is key to successful implementation. TMI/TMLI represents a paradigmshift from TBI towards novel strategies to integrate a safer and more effective target-specific radiation therapy into HCT conditioning beyond what is possible with TBI and will help expand and redefine the role of radiotherapy in HCT. [ABSTRACT FROM AUTHOR]

A new aryltetralin lignan, bupleroid A (1), along with ten known analogues (2–11) were isolated from Bupleurum marginatum. The structures of these isolates were determined by 1D and 2D NMR, HRESIMS, and ECD data analysis. In addition, the DPPH radical scavenging capacities of all compounds were evaluated. Compound 6 exhibited good DPPH radical scavenging activity at a concentration of 50 μM. [ABSTRACT FROM AUTHOR]

Water resources are indispensable to human society. High-quality development (HQD) is a multi-faceted, demanding, and sustainable pattern. High-quality development level (HQDL) is an indicator of regional development. Its quantitative calculation is helpful to intuitively understand the current regional development situation, and helps departments make timely adjustments. Spatial equilibrium degree (SED) reflects the development balance among regions. Understanding spatial equilibrium can clarify regional development differences, promote the sharing of successful experiences, and then achieve common progress. Considering the current development and utilization situation of China's water resources, this study established an improved evaluation index system for HQDL, under water resources constraints. Then, we applied the proposed "single index quantification and multiple index synthesis and poly-criteria integration (SMI-P)" method to quantitatively evaluate the HQDL of China's 31 provincial-level administrative regions (PLARs), from 2010 to 2019. Finally, the calculation method of SED was employed to assess the SED of indicators and HQD in Mainland China. Results show that: (1) the HQDL of 31 PLARs showed a steady upward trend from 2010 to 2019. There were decrease tendencies from the coast to inland, and southeast to northwest in terms of spatial distribution, which shows that China's HQD has achieved remarkable results in the past 10 years, and the development of coastal areas is better; (2) The SED of HQD displayed a slow upward trend, and it has remained relatively stable after 2015, indicating that the spatial difference of HQD continued to shrink before 2015 and was relatively stable after that; (3) Water resource constraints played a significant role in well-developed areas, while the economic and social level was still the main constraint in medium and poor level areas. In addition, the spatiotemporal variation of HQDL, SED of HQD and indicators, and constraint effects of water resources on regional HQD, were fully discussed. Our findings not only provide new ideas for future research on HQD, but also possess great significance to China's HQD in the new era. [ABSTRACT FROM AUTHOR]

Purpose/objectives: The aim of this study is to compare intrafractional motion using two commercial non‐invasive immobilization systems for linac‐based intracranial stereotactic radiosurgery (SRS) under guidance with a surface‐guided radiotherapy (SGRT) system. Materials/methods: Twenty‐one patients who received intracranial SRS were retrospectively selected. Ten patients were immobilized with a vacuum fixation biteplate system, while 11 patients were immobilized with an open‐face mask system. A setup margin of 1 mm was used in treatment planning. Real‐time surface motion data in 37 treatment fractions using the vacuum fixation system and 44 fractions using the open‐face mask were recorded by an SGRT system. Variances of intrafractional motion along three translational directions and three rotational directions were compared between the two immobilization techniques with Levene's tests. Intrafractional motion variation over time during treatments was also evaluated. Results: Using the vacuum fixation system, the average and standard deviations of the shifts were 0.01 ± 0.18 mm, ‐0.06 ± 0.30 mm, and 0.02 ± 0.26 mm in the anterior–posterior (AP), superior–inferior (SI), and left–right (LR) directions, and ‐0.02 ± 0.19°, ‐0.01 ± 0.13°, and 0.01 ± 0.13° for rotations in yaw, roll, and pitch, respectively; using the open‐face mask system, the average and standard deviations of the shifts were ‐0.06 ± 0.20 mm, ‐0.02 ± 0.35 mm, and 0.01 ± 0.40 mm in the AP, SI, and LR directions, and were 0.05 ± 0.23°, 0.02 ± 0.21°, and 0.00 ± 0.16° for rotations in yaw, roll, and pitch, respectively. There was a significant increase in intrafractional motion variance over time during treatments. Conclusion: Patients with the vacuum fixation system had significantly smaller intrafractional motion variation compared to those with the open‐face mask system. Using intrafractional motion techniques such as surface imaging system is recommended to minimize dose deviation due to intrafractional motion. The increase in intrafractional motion over time indicates clinical benefits with shorter treatment time. [ABSTRACT FROM AUTHOR]

Purpose: Single isocenter technique (SIT) for linear accelerator‐based stereotactic radiosurgery (SRS) is feasible. However, SIT introduces the potential for rotational error which can lead to geographical miss. Additional planning treatment volume (PTV) margin is required when using SIT. With the six degrees of freedom (6DoF) couch, rotational error can be minimized. We sought to evaluate the effect of the 6DoF couch on the dosimetry of patients with multiple brain metastases treated with SIT. Materials and Methods: Ten consecutive patients treated with SRS to ≥3 metastases were identified. Original treatments had MIT plans (MITP). The lesions were replanned using SIT. Lesions 5‐10 cm from isocenter had an additional 1mm of margin. Patients were replanned with these additional margins to account for inability to correct rotational error (SITPM). Multiple dosimetric variables and time metrics were evaluated. Dosimetry planning time (DPT) and patient treatment time (PTT) were evaluated. Statistics were calculated using the Wilcoxon signed‐rank test. Results: A total of 73 brain metastases receiving SRS, to a median of 6 lesions per patient, were identified. MITPs treated 73 lesions with 63 isocenters. On average, MITPs had a 19.2% higher brain V12 than SITPs (P = 0.017). For creation of SITPM, 30 lesions required 1 mm of additional margin, while none required 2 mm of margin. This increased V12 by 47.8% on average per patient (P = 0.008) from SITP to SITPM. DPT was 5.5 hours for SITP, while median for MITP was 12.5 hours (P = 0.005) PTT was 30 minutes for SITP, while median for MITP was 144 minutes (P = 0.005). Conclusions: SITPs are comparable to MITPs if rotational error can be corrected with the use of a 6DoF couch. Increasing margin to account for rotational error leads to a nearly 50% increase in V12, which could result in higher rates of radiation necrosis. Time savings are significant using SIT. [ABSTRACT FROM AUTHOR]

To solve the contradiction between regulation and protection of the water ecological environment in a dam-controlled river, it is necessary to identify the main influencing factors of that environment and the interactions between the water quantity, quality and ecology. In this paper, the redundancy analysis (RDA) technique is used to identify the key influencing factors of water eco-environment in the Shaying River, China. The multivariate nonlinear quantization method is used to quantify the interactive relationship between water quantity, water quality and water ecology, and a quantitative model of the dam-controlled river eco-environment is constructed. The results show the relative importance of the various environmental factors. The Shannon-Wiener diversity index is used to assess phytoplankton, zooplankton and benthos (P-SWI, Z-SWI and B-SWI, respectively). The R2 of the quantization models for P-SWI, Z-SWI and B-SWI in the fitting phase were 0.81, 0.72 and 0.66, respectively, and, in the validation phase, they were 0.36, 0.31 and 0.41, respectively. The results of this study can provide reference and support for the environmental regulation of dam-controlled rivers. [ABSTRACT FROM AUTHOR]

Graphical abstract Highlights • Three new and ten known ent -abietane diterpenoids were obtained from Euphorbia ebracteolata. • New diterpenoids 2 and 3 showed moderate cytotoxic activities against cancer cell lines. • New diterpenoid 3 displayed selective cytotoxic effects against cancer cell lines. Abstract Euphoroids A–C (1 – 3), three new ent -abietane-type diterpenoids, together with ten known analogues (4 – 13) were obtained from the roots of Euphorbia ebracteolata. The structures of these compounds were determined by extensive spectroscopic data analysis, including UV, HRESIMS, 1D-, and 2D-NMR data. The inhibitory effects of compounds 1 – 13 on human cancer cells were determined using the MTT assay. The results revealed that new compounds 2 and 3 showed moderate cytotoxic activities against human cancer cell lines. Especially, compound 3 displayed selective cytotoxic effect agains cancer cell lines. [ABSTRACT FROM AUTHOR]

Erratum: "Evaluation of repeatability and reproducibility of radiomic features produced by the fan-beam kV-CT on a novel ring gantry-based PET/CT linear accelerator" https://10.1002/mp.16399 In Ketcherside et al., 1 the COI disclosure statement missed disclosing three authors who are from commercial companies, thus the COI disclosure statement is corrected. CONFLICT OF INTEREST STATEMENT David Leung, Andrew Sundquist, and Calvin Huntzinger are employed by Reflexion Medical. [Extracted from the article]

A broadband linearly polarized single-layer reflectarray antenna constructed by element cells of triple gapped rings with phase-delay lines (TGR-PDLs) attached to the outer one is presented in this communication. The novel TGR-PDL element is composed of three circular rings, each with a pair of gaps which are orthogonally positioned, and two identical PDLs are attached to each half of the outer ring. The characteristics of the proposed element are first analyzed and then a linear and smooth phase response covering about 600° is obtained by adjusting the length of the PDL. Based on the element cell, an offset-fed reflectarray antenna of an octagon-shaped aperture with 266 mm in diameter is designed, fabricated, and measured to verify the broadband property of the proposed element. The measurement results show that about 31.5% of 1-dB gain bandwidth is realized, and the maximum gain at the center frequency of 10 GHz is about 25.78 dBi, which is equivalent to about 50% aperture efficiency. [ABSTRACT FROM PUBLISHER]

This study identifies the pufferfish species and detects tetrodotoxin (TTX) in roasted fish fillet samples collected in Beijing, Qingdao and Xiamen, China. The cytochrome c oxidase I (COI) gene was used as the target gene for identification of the pufferfish species in the samples. Enzyme-linked immunosorbent assay (ELISA) screened the TTX levels in samples that had been detected as containing pufferfish by DNA barcode. A total of 125 samples were identified by DNA barcodes; 32 (26%) samples contained pufferfish composition and, among them, 26 (81%) were the highly toxic speciesLagocephalus lunaris. All 32 samples containing the pufferfish composition were positive for TTX with levels ranging from 100 to 63 800 ng g–1. Most of the 32 samples contained the highly toxicL. lunaris. Based on the results, we suggest that the monitoring of roasted fish fillet should be strengthened and the processing procedures should be standardised to minimise TTX poisoning caused by pufferfish. [ABSTRACT FROM PUBLISHER]