Search

With the development of sports science and information technology, how to use mining technology to analyze the correlation between various track and field training programs plays an important role in the improvement of track and field training. A decision support system for track and field training is constructed using the Apriori algorithm and decision tree ID3 algorithm. By mining and analyzing different sports data of track and field athletes, the system blends scientific training theory and advanced training methods to create a set of reasonable track and field training programs for athletes. Through empirical research, after the optimization of the track and field training decision support system, 72.2% of the athletes whose physical fitness test 30-meter run scores were between 80 and 100 had bar pull-up scores between 0 and 55. The average performance of students’ 3000-meter run improved by 81.35s.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by developmental impairments, inattention, motor hyperactivity, and impulsivity. Currently, there is no effective intervention that can completely cure it. One of the pathogenic mechanisms of ADHD involves abnormalities in the norepinephrine (NE) pathway within the prefrontal cortex (PFC). In recent years, transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, has demonstrated promising potential in the treatment of neurological and psychiatric disorders. However, its application in the management of ADHD remains relatively unexplored. Previous studies have shown that taVNS exerts therapeutic effects on attention, cognition, arousal, perception, and behavioral regulation primarily through activating the vagus nerve conduction pathway, specifically targeting the nucleus tractus solitarius - locus coeruleus - NE pathway. These findings have led to the hypothesis that taVNS may be an effective intervention for ADHD, with NE and its pathway playing a pivotal role in this context. Therefore, this review comprehensively examines the correlation between NE pathway alterations in the PFC and ADHD, the mechanism of action of taVNS, and the potential role of the NE pathway in treating ADHD with taVNS, aiming to provide a theoretical foundation for clinical applications. [ABSTRACT FROM AUTHOR]

Transition‐metal‐catalyzed enantioselective transformations of aryl/aryl carbene are inherently challenging due to the difficulty in distinguishing between two arene rings in the reaction process thus remain largely less explored. The few successful examples reported so far, without exception, have all been catalyzed by Rh(II)‐complexes. Herein, we describe our successful development of a novel cationic Rh(I)/chiral diene catalytic system capable of efficient enantioselective B−H and O−H insertions with diaryl diazomethanes, allowing the access to a broad range of gem‐diarylmethine boranes and gem‐diarylmethine ethers in good yields with high enantioselectivities. Notably, previously unattainable asymmetric diarylcarbene insertion into the O−H bond was achieved for the first time. A remarkable feature of this newly designed Rh(I)/diene catalyst bearing two ortho‐amidophenyl substitutents is that it can distinguish between two arene rings of the diaryl carbene through a stereochemically selective control of π–π stacking interactions. DFT calculations indicate that the rotation‐restricted conformation of Rh(I)/diene complex played an important role in the highly enantioselective carbene transformations. This work provides an interesting and unprecedented stereocontrol mode in diaryl metal carbene transformations. [ABSTRACT FROM AUTHOR]

In the context of sustainable urban development, elucidating urban heat island (UHI) dynamics in arid regions is crucial. By thoroughly examining the characteristics of UHI variations and potential driving factors, cities can implement effective strategies to reduce their impacts on the environment and public health. However, the driving factors of a UHI in arid regions remain unclear. This study analyzed seasonal and diurnal variations in a surface UHI (SUHI) and the potential driving factors using Pearson's correlation analysis and an Optimal Parameters-Based Geographic Detector (OPGD) model in 22 cities in Xinjiang, northwest China. The findings reveal that the average annual surface urban heat island intensity (SUHII) values in Xinjiang's cities were 1.37 ± 0.86 °C, with the SUHII being most pronounced in summer (2.44 °C), followed by winter (2.15 °C), spring (0.47 °C), and autumn (0.40 °C). Moreover, the annual mean SUHII was stronger at nighttime (1.90 °C) compared to during the daytime (0.84 °C), with variations observed across seasons. The seasonal disparity of SUHII in Xinjiang was more significant during the daytime (3.91 °C) compared to nighttime (0.39 °C), with daytime and nighttime SUHIIs decreasing from summer to winter. The study also highlights that the city size, elevation, vegetation cover, urban form, and socio-economic factors (GDP and population density) emerged as key drivers, with the GDP exerting the strongest influence on SUHIIs in cities across Xinjiang. To mitigate the UHI effects, measures like urban environment enhancement by improving surface conditions, blue–green space development, landscape optimization, and economic strategy adjustments are recommended. [ABSTRACT FROM AUTHOR]

The South China Sea is rich in sea anemone resources, and the protein and peptide components from sea anemone toxins comprise an important treasure trove for researchers to search for leading compounds. This study conducted a comprehensive transcriptomic analysis of the tentacles and column of Macrodactyla doreensis and explored the distribution and diversity of proteins and peptides in depth using bioinformatics, initially constructing a putative protein and peptide database. In this database, typical peptide families are identified through amino acid sequence analysis, and their 3D structures and potential biological activities are revealed through AlphaFold2 modeling and molecular docking. A total of 4239 transcripts were identified, of which the putative protein accounted for 81.53%. The highest content comprised immunoglobulin and a variety of proteases, mainly distributed in the column and related to biological functions. Importantly, the putative peptide accounted for 18.47%, containing ShK domain and Kunitz-type peptides, mainly distributed in the tentacles and related to offensive predatory behavior. Interestingly, 40 putative peptides belonging to eight typical peptide families were identified, and their structures and targets were predicted. This study reveals the diversity and complexity of Macrodactyla doreensis toxins and predicts their structure and targets based on amino acid sequences, providing a feasible approach for research regarding the discovery of peptides with potentially high activity. [ABSTRACT FROM AUTHOR]

Breast cancer is rare in men and is managed using strategies similar to those for breast cancer in women. This study retrospectively analyzed the clinicopathological features, treatment, and survival of male breast cancer (MBC). A total of 66 patients with MBC admitted into Xijing Hospital from August 2006 to March 2024 were reviewed. Data were collected from patients' hospital records and breast cancer database of Xijing Hospital. The incidence of MBC tended to increase from 2018, with affected individuals being older than those with female breast cancer (FBC). The most common histological type of MBC was invasive carcinoma, with positive hormone receptor status. A total of 62 (93.9%) patients with MBC underwent modified radical mastectomy. Chemotherapy was administered to 39 (59.1%) patients, while endocrine therapy was received by 14 patients (21.2%) and radiotherapy by nine patients (13.6%). Survival analysis indicated that the median overall survival (OS) of patients with MBC was 46.7 months (0.9–184.8 months). As of the latest data, 58 patients (87.9%) with MBC are alive. Factors significantly associated with survival included age (χ2 = 3.856, p =.050), estrogen receptor (χ2 = 10.427, p =.005), molecular types (χ2 = 10.641, p =.031), P63 (χ2 = 2.631, p <.001), and endocrine therapy (χ2 = 31.167, p <.001). These findings provide valuable insights into MBC within the Chinese population and serve as a reference for the standard treatment of MBC. [ABSTRACT FROM AUTHOR]