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There is still no reliable solution for obtaining Digital Terrain Models (DTM) under the canopy in areas with difficult access on foot. The difficulty lies in the configuration of the environment. This configuration does not allow access on foot to all areas of the terrain. In addition, the dense leaf litter complicates any photogrammetry technique. Currently, LiDAR is a technique that could help solve this problem. The best solution to this problem requires many samples over hostile environment and LiDAR flight simulation can be a good option to approximate the problem. For this reason, this research carries out a series of LiDAR flight simulations, using Helios++, in different types of scenes under the canopy with the aim of analysing the influence of the density of trees and the mean terrain slope over the number of points that bounce off the terrain. Additionally, this research enables the scientific community to approach the problem and guide future research based on the obtained results.

Abstract Background Over the past decade, numerous studies on potential factors contributing to ventilation-induced lung injury have been carried out. Mechanical power has been pointed out as the parameter that encloses all ventilation-induced lung injury-contributing factors. However, studies conducted to date provide data regarding mechanical power during the early hours of mechanical ventilation that may not accurately reflect the impact of power throughout the period of mechanical ventilatory support on intensive care unit mortality. Methods Retrospective observational study conducted at a single center in Spain. Patients admitted to the intensive care unit, > o = 18 years of age, and ventilated for over 24 h were included. We extracted the mechanical power values throughout the entire mechanical ventilation in controlled modes period from the clinical information system every 2 min. First, we calculate the cutoff-point for mechanical power beyond which there was a greater change in the probability of death. After, the sum of time values above the safe cut-off point was calculated to obtain the value in hours. We analyzed if the number of hours the patient was under ventilation with a mechanical power above the safe threshold was associated with intensive care unit mortality, invasive mechanical ventilation days, and intensive care unit length of stay. We repeated the analysis in different subgroups based on the degree of hypoxemia and in patients with SARS CoV-2 pneumonia. Results The cut-off point of mechanical power at with there is a higher increase in intensive care unit mortality was 18 J/min. The greater the number of hours patients were under mechanical power > 18 J/min the higher the intensive care unit mortality in all the study population, in patients with SARS CoV-2 pneumonia and in mild to moderate hypoxemic respiratory failure. The risk of death in the intensive care unit increases 0.1% for each hour with mechanical power exceeding 18 J/min. The number of hours with mechanical power > 18 J/min also affected the days of invasive mechanical ventilation and intensive care unit length of stay. Conclusions The number of hours with mechanical power > 18 J/min is associated with mortality in the intensive care unit in critically ill patients. Continuous monitoring of mechanical power in controlled modes using an automated clinical information system could alert the clinician to this risk.

AIM: To translate and culturally adapt the FRAIL scale into Spanish and perform a preliminary test of diagnostic accuracy in patients admitted to intensive care units. DESIGN: Cross-sectional diagnostic study. METHODS: Five intensive care units (ICU) in Spain were participated. Stage 1: Three native Spanish-speaking bilingual translators familiar with the field of critical care translated the scale from English into Spanish. Stage 2: Three native English-speaking bilingual translators familiar with critical care medicine. Stage 3: Authors of the original scale compared the English original and back-translated versions of the scale. Stage 4: Five nurses with more than 5 years of ICU experience and five critical care physicians assessed the comprehension and relevance of each of the items of the Spanish version in 30 patients of 3 different age ranges (65 years). RESULTS: The FRAIL scale was translated and adapted cross-culturally for patients admitted to intensive care units in Spain. The process consisted of four stages: translation, back translation, comparison and pilot test. There was good correspondence between the original scale and the Spanish version in 100% of the items. The participating patients assessed the relevance (content validity) and comprehensibility (face validity) of each of the items of the first Spanish version. The relevance of some of the items scored low when the scale was used in patients younger than 65 years. CONCLUSIONS: We have cross-culturally adapted the FRAIL scale, originally in English, to Spanish for its use in the critical care medical setting in Spanish-speaking countries. IMPLICATIONS FOR PROFESSIONALS: Physicians and nurses can apply the new scale to all patients admitted to the intensive care units. Nursing care can be adapted according to frailty, trying to reduce the side effects of admission to these units for the most fragile patients. REPORTING METHOD: The manuscripts authors have adhered to the EQUATOR guidelines, using the COSMIN reporting guideline for studies on the measurement properties of patient-reported outcome measures. PATIENT OR PUBLIC CONTRIBUTION: In a pilot clinical study, we applied the first version of the FRAIL-Spain scale to intensive care unit (ICU) patients. Five nurses with more than 5 years of ICU experience and five critical care physicians assessed the relevance (content validity) and comprehensibility (face validity) of the five items of the first Spanish version. Relevance was assessed using a 4-point Likert scale ranging from 1 (no relevance) to 4 (high relevance), and comprehensibility was assessed as poor, acceptable or good. Each health professional applied the scale to three patients (total number of patients = 30) of three different age ranges (65 years) and recorded the time of application of the scale to each patient. Although the frailty scales were initially created by geriatricians to be applied to the elders, there is little experience with their application in critically ill patients of any age. Therefore, more information is needed to determine the relevance of using this scale in critical care patients. In this pilot study, we considered that nurses and critical care physicians should evaluate frailty using this adapted scale in adult patients admitted to the Intensive Care Units.

Abstract Fish age and growth data are crucial for understanding vital species’ traits and their populations. Boarfish is a pelagic species widely distributed in the Northeast Atlantic that is one of the most discarded non-commercial species on the Portuguese coast. Due to its potential valorisation as a new fishery in the Northeast Atlantic, boarfish has become object of interest in several published studies. However, since no age standard protocol has been implemented for boarfish, studies have used a variety of different otolith preparation techniques to estimate age, leading to contradicting and discrepant results. This research aims to consolidate biological insights into boarfish age and growth, lay the foundation for a standardized ageing protocol and serve as a benchmark study for the Portuguese west coast before commercial exploitation. Through the comparison of two otolith ageing methodologies, this study recommends using whole otoliths as the best method, revealing a maximum age of 15 years. The growth pattern estimated, indicated a biphasic growth pattern, with a faster initial growth rate that slows down at 2.4 years, the moment of change, when energy is allocated for sexual maturation. This finding was corroborated by a maturity ogive and analysis of fish size and otolith length relationship.

The prevalence of endoparasites associated with chaetognath abundance in the coastal waters of the Mexican Central Pacific was studied fortnightly from November 2010 to December 2011. A total of 35 (0.21%) out of 16,407 chaetognaths were found to be parasitized. Five out of twelve chaetognath species (Flaccisagitta enflata, F. hexaptera, Parasagitta euneritica, Serratosagitta pacifica, Zonosagitta bedoti) were found to be parasitized by nine endoparasitic taxa: Protists (two morphotypes), digenean metacercariae [Didymozoidae, Hemiuridae, Parahemiurus sp., Lepocreadiidae, Prosorhynchus sp. (Bucephalidae)], and cestodes (metacestodes) [Tetraphyllidea (two morphotypes)]. Parasagitta. euneritica and Z. bedoti were the most abundant chaetognath species, and Protist sp. 2 and Tetraphyllidea sp. 1 were the most abundant parasites. The highest prevalence for most of the endoparasite species occurred in June, and the values varied according to three hydroclimatic periods: stratified (S), semi-mixed (SM), and mixed (M). Eight non-infected chaetognath species, two parasitized chaetognaths (F. enflata and S. pacifica), and two parasites (Protist sp. 1 and Tetraphyllidea sp. 2) were associated with warm temperatures (S and SM periods); in contrast, P. euneritica, Z. bedoti, parasitized F. hexaptera, and the parasite Tetraphyllidea sp. 1 showed a strong local preference for cooler temperatures, high productivity, and high biomass conditions (M periods). We discovered the occurrence of the digenean Prosorhynchus sp. (Bucephalidae) parasitizing the chaetognath P. euneritica, and this is the first report of Prosorhynchus parasitizing chaetognaths worldwide. We also confirmed the presence of Lepocrediidae (metacercariae larval stage) infecting F. hexaptera, a parasite that had only been recorded infecting other chaetognaths of the Atlantic Ocean. The parasite diversity affecting the chaetognath populations of the Central Mexican Pacific coast likely differs between the offshore, outer slope areas, and the surveyed coastal system.

Abstract Around 1526, Emperor Charles V decided to build a new Renaissance palace in addition to the Nasrid palaces in the Alhambra of Granada, a monumental site currently included in the United Nations Educational, Scientific and Cultural Organisation (UNESCO) World Heritage List. In that period, a large floor plan, which is preserved today at the Library of the Royal Palace of Madrid, was drawn to represent the building and its surroundings. Although this anonymous drawing has attracted considerable historiographic interest, a study of the graphical aspects analysed here, namely, paper assemblage, drawing technique, representation system, metrology, graphical scale, dimensioning, and labelling, is lacking. To accomplish this analysis, the original document was carefully examined and digitalised with high definition. This process allowed a comprehensive graphic analysis, utilising other drawings from the same period as a comparative reference and studying for the first time the major characteristics of one of the most relevant architectural drawings of the 16th century.

Consumer attitudes and acceptance of emerging technologies in the food sector, as well as their application, are determining factors for their successful implementation. In this study, a survey was conducted in order to better know and understand the perception, motivation and consumption associated with fortified foods and 3DPF (3-Dimensional Printing Food). Key points such as food neophobia and factors involved in the opinion forming process towards 3DPF were included in the questionnaire (namely, perceived benefits, willingness to consume, food engagement, preference for familiar foods and affinity with digital tools). The results showed that the gender influences the knowledge in 3D printing as a technology and that 51.6 % of consumers are willing to try 3DPF. Consumers who want healthy food adapted to their needs are also more receptive to foods produced on 3D printers. 54.1 % of consumers indicate that if 3DPF were nutritionally richer than an equal and/or existing product on the market, they would be willing to buy it. Respondents also mentioned fruit and vegetable by-products and fish with no commercial value as the most suitable raw materials for 3D printing. Thus, it can be concluded that there is a clear motivation to try 3DPF, providing an opportunity for their inclusion in the future food chain.

Virtual reality and databases are two technological domains employed in many scientific fields. In archeology, several works are being developed along these lines. This paper presents the workflow for the creation of an executable virtual reality: it integrates a virtualization of the archaeological site of Venta Micena (Granada, Spain) and a database of some of the most relevant archaeological remains from that site. The strength and novelty of this project are that it allows any user or researcher to walk through the archaeological site, pick up and put down any of the remains found there, access the database of the archaeological remains from any place and time, and visualize them in stereoscopic mode, which could unveil new information and conclusions. This document moreover discusses the contributions and possible limitations of this type of technology, as well as key concepts and the significance of archaeological excavation.

Importance: Artificial intelligence (AI) application in guiding the acquisition of ultrasonography images represents a pioneering field of research. A new developed hybrid deep-learning (DL) algorithm, trained on more than high quality 60.000 curated and labelled reference images (distilled from a set of more than 600.000 abdominal ultrasound images) from La Paz Hospital, can provide real-time prescriptive guidance for novice operators to obtain standard planes images of the target organs. Objective: This study aims to evaluate the capability of novice users to acquire diagnostic-quality abdominal ultrasound images of the urinary system using the deep-learning (DL)-based guiding research prototype provided by GMV. Design: Setting, and Participants: This prospective diagnostic study was conducted within the facilities of an academic hospital. A cohort of 24 technically-oriented volunteers, lacking prior knowledge in anatomy or medicine and without experience in conducting ultrasound examinations, was recruited. After a brief training session focused on various organs, each pair of volunteers performed scans of each other's urinary system, exclusively guided by AI support. These scans were subsequently repeated by experienced sonographers using identical ultrasound equipment but without AI assistance. Four radiologists, each with decades of experience, independently and blindly assessed the quality of each acquisition. Results: Over 90.6 % of the images scanned by volunteers were identified as valuable clinical picture, using only an AI-based guidance system. This is nearly comparable to the results achieved by experienced radiologists, who attained a 98.6 % success rate. Conclusions: This deep-learning (DL) prototype enables novices lacking experience in ultrasonography to acquire diagnostic ultrasound images suitable for subsequent expert evaluation. The modular prototype works on a large range of ultrasound device models and vendors. This advancement has the potential to extend the application of ultrasound beyond traditional clinical environments, particularly in situations requiring immediate anatomical and functional interrogation, as well as in resource-limited settings.

The use of scaffolds, three-dimensional porous, biodegradable and biocompatible structures, that can be produced from natural polymers, synthetics, ceramics and metals is crucial in the tissue engineering field. Chitosan is a polysaccharide of natural origin, found in the exoskeleton of marine arthropods and in the cell wall of fungi, with enormous popularity in the production of three-dimensional materials for Tissue Engineering, in particular bone repair. This polymer has several advantages in the production of these structures in bone regeneration and repair: biodegradability, biocompatibility, non-toxicity and antimicrobial properties. This study aimed to prepare porous scaffolds, for bone repair of degenerative diseases in the spine with better performance and less secondary effects, based on chitosan and another biopolymer (sodium alginate) with the incorporation of calcium phosphates (hydroxyapatite and β-tricalcium phosphate), for tissue engineering application. The obtained scaffolds were object of a detailed characterization, namely with regard to their porosity through the ethanol method, degradation, positron annihilation spectroscopy (PAS), mechanical properties, scanning electronic microscope (SEM), thermal stability through thermogravimetric analysis (TGA), chemical composition through X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The results obtained showed that the different scaffolds presented pores able to support osteoid matrix growth. The crosslinking of scaffolds was also evaluated and resulted in pores with smaller dimensions and higher regularity in the chitosan-sodium alginate polymer without calcium phosphate scaffold. It was also possible to observe the effect of inorganics on mixed-matrix scaffolds, both morphologically and chemically. These scaffolds showed promising results in terms of mechanical and chemical properties, along with promising porosity for tissue regeneration applications.

Introduction: Childhood excess weight is a growing public health problem. The aim of this study was to assess temporal trends in the prevalence of overweight, obesity and central obesity in schoolchildren aged 6–9 years in Spain between 2011 and 2019 based on demographic and socioeconomic characteristics. Methodology: The analysis included data from the 2011, 2015 and 2019 rounds of the cross-sectional observational and descriptive ALADINO study in schoolchildren of both sexes aged 6–9 years. We conducted a descriptive analysis of the trends in the prevalence of overweight and obesity (defined according to the criteria of the World Health Organization and the International Obesity Task Force) and of central obesity, in addition to associated demographic and socioeconomic variables. Results: Between 2011 and 2019, the prevalence of overweight (WHO criteria) decreased in boys aged 6, 7 and 8 years (by −5.4%, −5.7% and −5.3%, respectively) and boys whose parents had a higher educational attainment (by −5.3%). In relation to the socioeconomic level, overweight in boys declined at all income levels. However, between 2011 and 2019, both the prevalence of overweight in girls and the prevalence of obesity (applying the WHO and IOTF criteria) and the prevalence of central obesity in both sexes remained stable. Conclusions: The prevalence of overweight and the prevalence of obesity in schoolchildren aged 6–9 years in Spain remain high. Between 2011 and 2019, the prevalence of overweight in children aged 6–8 years and in children whose parents had university degrees decreased, whereas obesity in boys, overweight and obesity in girls and central obesity in both sexes remained stable. Resumen: Introducción: El exceso de peso infantil es un problema de salud pública creciente. El objetivo del trabajo es estudiar la evolución de la prevalencia de sobrepeso, obesidad y obesidad central en escolares de 6 a 9 años en España entre 2011 y 2019 según características demográficas y socioeconómicas. Metodología: Se incluyeron las rondas 2011, 2015 y 2019 del estudio observacional, descriptivo y transversal ALADINO en escolares de ambos sexos de 6 a 9 años. Se realizó un análisis descriptivo de la evolución de la prevalencia de sobrepeso y obesidad según los criterios de la Organización Mundial de la Salud (OMS) y la International Obesity Task Force (IOTF), así como obesidad central, y las variables demográficas y socioeconómicas asociadas. Resultados: Entre 2011 y 2019 se redujo la prevalencia de sobrepeso (critrerios OMS) en niños de 6, 7 y 8 años (−5,4, −5,7 y −5,3 puntos porcentuales respectivamente) y niños cuyos progenitores tenían estudios superiores (−5,3 puntos porcentuales). Por renta, el sobrepeso en niños se redujo en todos los niveles de ingresos. Sin embargo, entre 2011 y 2019, se mantuvieron estables tanto la prevalencia de sobrepeso en niñas como la prevalencia de obesidad según las referencias OMS e IOTF y la de obesidad central en ambos sexos. Conclusiones: Las prevalencias de sobrepeso y obesidad en escolares de 6 a 9 años en España siguen siendo altas. Entre 2011 y 2019 disminuyó la prevalencia de sobrepeso en niños de 6 a 8 años y aquellos cuyos progenitores tienen estudios universitarios, mientras que la obesidad en niños, el sobrepeso y la obesidad en niñas, y la obesidad central en ambos sexos han permanecido estables.

Abstract The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 200 individuals, including infants (0-12 months old; 55% females, 45% males) and their respective mothers and grandmothers, were analyzed using two independent metabolomics platforms and metagenomics. For metabolomics, gas chromatography and capillary electrophoresis coupled to mass spectrometry were applied. For metagenomics, both 16S rRNA gene and shotgun sequencing were performed. Here we show that infants greatly vary from their elders in fecal microbiota populations, function, and metabolome. Infants have a less diverse microbiota than adults and present differences in several metabolite classes, such as short- and branched-chain fatty acids, which are associated with shifts in bacterial populations. These findings provide innovative biochemical insights into the shaping of the gut microbiome within the same generational line that could be beneficial in improving childhood health outcomes.

Marta Trivi, una periodista cultural especializada en videojuegos, sugiere que las comunidades que surgen en torno a los videojuegos desde finales de los ochenta son precursoras de las estrategias de desinformación desplegadas por la extrema derecha desde hace décadas, coincidiendo con el surgimiento del trumpismo. Con este escenario de fondo también plantea una serie de correspondencias entre estas comunidades, entendidas como laboratorios de marketing y manipulación social, y la violencia y misoginia actuales. El texto que presentamos a continuación da buena cuenta de estas conexiones. Basado en la entrevista concedida el 25 de septiembre de 2023, y las reflexiones e intercambios que la siguieron.

Saguinus bicolor is one of the most endangered primates in the Amazon, mainly due to threats related to human activities, such as deforestation and habitat fragmentation. Moreover, the encroachment of Saguinus midas, a widely distributed species, into the restricted range of S. bicolor, poses further conservation challenges and extinction risks. This study focuses on the potential niche overlap and competition between these two species, which are closely related callitrichid primates with a parapatric distribution. We employed the support vector machine (SVM) algorithm to investigate the potential of invasion by S. midas into the area of occurrence of S. bicolor by quantifying and comparing the habitat suitability for both species. We used environmental variables that are known to be relevant descriptors of callitrichid niches and a similarity test was applied to assess niche overlap between the two species. Our analysis reveals that the majority of the area occupied by S. bicolor exhibits higher habitat suitability for S. midas than for S. bicolor. Furthermore, we found a high niche similarity between the species. These results suggest a significant invasive potential of S. midas into the range of S. bicolor. The research highlights the concerning prospects for the long-term persistence of S. bicolor, emphasizing the urgent need for conservation measures. The conservation and maintenance of an ecologically functional urban forest matrix, along with the preservation of habitat quality and connectivity in rural areas, are crucial. Monitoring the current contact areas between the two species and the areas indicated as highly and moderately suitable for S.midas in the range of S. bicolor is also essential, and the observed trends in the occupation of these areas need to be incorporated into adaptive conservation strategies to protect less anthropogenically impacted areas. The findings are expected to contribute to the ongoing National Action Plan for the conservation of S. bicolor and support the management and conservation efforts for the species.

ObjectiveThe purpose of this study was to determine, for the first time, whether the application of a self-management program with global postural re-education (GPR) influences stress and sleep quality in female health science students.MethodsIn this randomized controlled trial pilot study, forty-one female health science students were randomized into a control group (n=21) and an intervention group (n=20). Participants underwent 8 weeks of self-management with and without GPR, after familiarization and therapy training. Outcomes included the State-Trait Anxiety Inventory (STAI) questionnaire and cortisol levels in saliva measured with the “CORTISOL Saliva ELISA SA E-6000” kit. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI) and a Sleep Diary; total sleep time (TST), sleep onset latency (SOL), wakefulness after sleep onset (WASO), sleep efficiency (SE), and perceived sleep quality or satisfaction were assessed using the Likert scale.ResultsAfter self-treatment with GPR, participants in the intervention group showed lower cortisol levels compared to the control group (p = 0.041). Additionally, the intervention group demonstrated statistically significant improvements in sleep quality according to their PSQI (p = 0.010), STAI (p = 0.043), SOL (p = 0.049), and SE (p = 0.002).ConclusionThis study shows that self-management through GPR helps reduce stress and improve sleep quality in female health science students.Clinical Trial Registrationhttps://clinicaltrials.gov/, identifier NCT05488015.

Las lesiones deportivas son una problemática que afecta a todos los practicantes a cualquier actividad física sin importar la edad, sexo, nivel deportivo o experiencia. Una de las facetas que tiene el entrenamiento sobre los deportistas es reducir la probabilidad de lesión mediante el entrenamiento físico o preventivo. Objetivo: El objetivo de esta investigación fue realizar dos revisiones bibliográficas: una de ellas centrada en conocer la etiología de las lesiones de los practicantes de baloncesto, y la segunda sobre los métodos más empleados para la prevención de las lesiones. Método: Para ambas revisiones se realizó una búsqueda bibliográfica en la WOS de los estudios publicados en los últimos 10 años, obteniendo 57 artículos para la primera revisión y 15 estudios para la segunda. Resultados: Los resultados han mostrado que las lesiones más comunes se producen en la rodilla y tobillo, que los jugadores masculinos se lesionan más que los femeninos, siendo afectada con mayor frecuencia los tejidos blandos, sin contactar con otro jugador y durante la competición. Entre las técnicas preventivas activas más empleadas se encuentra el entrenamiento propioceptivo y neuromuscular, mientras que en las técnicas pasivas destacan el descanso y el empleo de tobilleras. Conclusiones: Por todo ello, se concluye que son necesarios más estudios que reúnan la etiología de las lesiones de los practicantes de baloncesto, puesto que los resultados son heterogéneos.

IntroductionFeeding local forages to ruminants is a promising strategy for enhancing metabolic processes, promoting sustainable farming, and improving product quality. However, studies comparing the effects of different forages on rumen histology and meat attributes of heifers are limited and variable.Material and methodsThis study evaluated the benefits of incorporating local forages into heifer diets by comparing barley straw (BS) and oat hay (OH) on heifer attributes focusing on meat quality (MQ) and rumen status (RS). Sixteen crossbred (Charolais x Limousin) female heifers (7 months of age, 263 ± 10.50 kg) were randomly assigned to two dietary treatments (BS or OH) over 120 days.Results and discussionHeifers fed OH showed enhanced RS (p 0.05) were found in animal performance, chemical composition, and technological properties of the meat between the dietary groups, while lower levels (p

Higher education in health study programs is particularly focused on the development of technical skills, despite there being a consensus on the importance of training students regarding socioemotional and life skills. The aim of this study was to characterize and explore correlations between socioemotional skills and decision-making styles in undergraduate health students. Undergraduate students (18-25 years old) were recruited at a School of Health Sciences in Portugal. Participants were characterized in terms of sociodemographic data, socioemotional skills (Study on Social and Emotional Skills questionnaire) and decision-making styles (Melbourne Decision Making questionnaire). Descriptive statistics and correlations between questionnaires´ subscales were calculated. Students presented higher scores in tolerance (34.8±3.4), cooperation (34.7±2.4), empathy (31.1±3.2), vigilance (16.0±1.9), and procrastination (9.9±2.1). Assertiveness presented negative correlations with buck-passing ("rho"=-0.43, p<0.01) and procrastination ("rho"=-0.38, p<0.01) and positive correlation with vigilance ("rho"=0.22, p=0.03). Students demonstrated higher values in empathy, cooperation, and tolerance skills, meaning they tend to be kind and care for others' well-being. Vigilance style is related to assertiveness characterizing hard working leaders able to pay attention to others' needs. Training that involves socioemotional skills might be crucial for the style of decision-making in future health professionals.

The muqarnas are small pieces grouped together, adopting surprising three-dimensional forms. They are a symbol of identity of the 14th century Nasrid architecture at Alhambra in Granada. This research’s aim is to graphically analyze the plaster muqarnas dome located to the south of the Sala de los Reyes, in the Palacio de los Leones. The methodology followed combines historical images analysis and modern digital graphic techniques. First, a compilation of unpublished drawings and photographs documenting architectural transformations and significant alterations in the roof structures since the 16th century is provided. Although these muqarnas were drawn by Jones and Goury in the 19th century, the current research identifies and draws, digitally for the first time, its nearly two thousand pieces of this dome. Additionally, metric data of the current state has been collected using 3D laser scanning, revealing significant deformations. In this way, the knowledge of these fragile architectural elements is achieved to promote their heritage dissemination and to facilitate the conservation of a monumental site included in the UNESCO World Heritage List.

Abstract Background Seroma after breast cancer surgery is a frequent entity; therefore, different products have been described in literature with the aim to reduce it. The most studied ones have been the sealants products, being tested with aspirative drains. Symptomatic seroma represents the 19% after axillary lymphadenectomy without drains. The aim of this study is to analyze the effect of a sealant in the seroma control after axillary lymphadenectomy without drains and identify the risk factors related to symptomatic seroma. Methods This is a prospective, multicenter, international, and randomized clinical trial. Patients undergoing conservative surgery and axillary lymphadenectomy for breast cancer will be randomized to control group (lymphadenectomy without sealant) or interventional group (lymphadenectomy with sealant Glubran 2®). In any of the study groups, drains are placed. Patients who received neoadjuvant treatment are included. Measurements of the study outcomes will take place at baseline; at 7, 14, and 30 days post-surgery; and at 6–12 months. The primary outcome is symptomatic seroma. Secondary outcomes are seroma volume, morbidity, quality of life, and lymphedema. Discussion Several studies compare the use of sealant products in axillary lymphadenectomy but generally with drains. We would like to demonstrate that patients who underwent axillary lymphadenectomy could benefit from an axillary sealant without drains and reduce axillary discomfort while maintaining a good quality of life. Assessing the relationship between axillary volume, symptoms, and related risk factors can be of great help in the control of seroma in patients who received breast cancer surgery. Trial registration ClinicalTrials.gov, NCT05280353. Registration date 02 August 2022.

La economía colaborativa surgió hace más de una década como una forma sostenible y social de consumir. Sin embargo, sus promesas se disolvieron rápidamente, revelando el hype colaborativo como otra vuelta de tuerca de las lógicas capitalistas al amparo de los procesos de digitalización en tiempos de crisis. En este artículo describimos el auge y caída de este paradigma para aclarar la confusión conceptual que permitió agrupar en la misma categoría plataformas sin fines de lucro y startups financiadas por capital de riesgo. Seguidamente, establecemos las condiciones bajo las cuales las prácticas de compartir pueden promover la satisfacción de necesidades sociales de manera más sostenible, conectando con los principios del decrecimiento, un paradigma que aboga por la necesidad de disminuir la actividad económica para frenar la crisis climática. Basándonos en investigaciones previas, analizamos el potencial transformador de algunas iniciativas que se consideraron parte del paradigma colaborativo para evaluar su potencial transformador.

BackgroundDuring the educational stage, academic achievement depends on various social, family, and personal factors. Among the latter, executive skills in everyday life play a significant role in dealing with the academic demands of adolescents. Therefore, the aim of this study is to ascertain the effects of executive symptomatology in everyday functioning on academic achievement in adolescents.MethodThe study involved 910 students aged between 13 and 15 years (M = 14.09, SD = 0.68) from both public and private schools in the Community of Madrid. The DEX, BDEFS-CA, and BRIEF-SR questionnaires were utilised to assess executive difficulties, while grades in language, mathematics, and natural sciences were used as a measure of academic achievement.ResultsThe data revealed statistically significant differences in working memory, emotional control, materials organisation, and task completion. In relation to language and natural sciences subjects. In the case of mathematics, emotional control and task completion were significant variables.ConclusionOur results indicate that certain executive skills that are manifested in everyday life activities can contribute, albeit in a variable way, to academic achievement in the subjects studied. This aspect is relevant insofar as it allows us to develop preventive interventions based on the executive training of these everyday skills.

Objective: Frailty is a syndrome that predisposes older individuals to adverse health outcomes, such as disability, dependence, falls, hospitalization, post-operative complications, and poor health in general. This study aimed to identify factors associated with frailty in older people with chronic diseases in Colombia. Methods: A cross-sectional study was conducted with a nonprobabilistic sample of 230 older people (aged ⩾ 60 years) from four Colombian cities. Frailty was based on Fried’s phenotype (frail defined as having ⩾3 criteria). Comorbidities were classified based on Charlson’s Comorbidity Index and key questionnaires for activities of daily living (ADLs) were evaluated. Results: Most were female (57.8%) with a mean ± SD age of 71.9 ± 8 years. Among them, 27.4% were frail and 58.7% were prefrail. Female gender, age ⩾ 75 years, low educational and socioeconomic level, dependence on ADLs, and cognitive impairment were associated with higher odds of prefrailty/frailty. Conclusions: Prefrailty and frailty are common among older people with chronic diseases in Colombia. This syndrome is associated with social and health-related conditions, which should be addressed when providing care for these patients.

The paper analyzes the importance of socially responsible public procurement from the practical perspective of the validity of the contracts in which they are incorporated. In particular, the aim is to analyze the impact that the inclusion of social clauses or criteria shall have on these contracts and there are provided practical guidelines for their inclusion depending on the stage of the contract at which they are introduced. In particular, the limitations imposed on these clauses by the administrative tribunals for contractual remedies and the uncertainty that has arisen, as well as proposed solutions, are examined.

Abstract Background The availability of multiple treatments for type 1 Gaucher disease increases the need for real-life studies to evaluate treatment efficacy and safety and provide clinicians with more information to choose the best personalized therapy for their patients. Aims To determine whether treatment with eliglustat produces, in adult GD1 patients, ans optimal response in daily clinical practice. Methods We designed a real-life study with 2 years of follow-up (TRAZELGA [GEE-ELI-2017-01]) to uniformly evaluate the response and adverse events to eliglustat treatment. This study, conducted in 30 patients across Spain and previously treated with other therapies, included the evaluation of safety and efficacy by assessing visceral enlargement, bone disease (DEXA and T and Z scores), concomitant treatments and adverse events, as well as a quality of life evaluation (SF-36). In addition, the quantification of classical biomarkers (chitotriosidase activity, CCL18/PARC and glucosylsphingosine (GluSph)) and new candidates for GD biomarkers (YKL-40, cathepsin S, hepcidin and lipocalin-2 determined by immunoassay) were also assessed. Non-parametric statistical analysis was performed and p

Abstract Background Survivors of critical illness are frequently left with a long-lasting disability. We hypothesised that patients who developed delirium during ICU stay, compared with patients who did not, would have worse health-related quality of life following a critical illness. Methods Prospective longitudinal observational and analytical study assessing functional independence, frailty and perceived quality of life measured with the Barthel Index, the Clinical Frailty Scale, and the SF-36, comparing patients who developed delirium during ICU stay and patients who did not. The questionnaires were used at different times during the follow-up (upon ICU admission, at ICU discharge, at hospital discharge and 2 years after hospital discharge). Results In a cohort of 1462 patients, we matched 93 patients who developed delirium (delirium group) with 93 patients who did not develop delirium (no-delirium group). Of 156 completed questionnaires (84.7%), we observed that (a) in each of the two groups of patients, the scores related to functional independence (Barthel Index) and frailty (Clinical Frailty Scale) tended to improve over time (p

Abstract Aim To translate and culturally adapt the FRAIL scale into Spanish and perform a preliminary test of diagnostic accuracy in patients admitted to intensive care units. Design Cross‐sectional diagnostic study. Methods Five intensive care units (ICU) in Spain were participated. Stage 1: Three native Spanish‐speaking bilingual translators familiar with the field of critical care translated the scale from English into Spanish. Stage 2: Three native English‐speaking bilingual translators familiar with critical care medicine. Stage 3: Authors of the original scale compared the English original and back‐translated versions of the scale. Stage 4: Five nurses with more than 5 years of ICU experience and five critical care physicians assessed the comprehension and relevance of each of the items of the Spanish version in 30 patients of 3 different age ranges (65 years). Results The FRAIL scale was translated and adapted cross‐culturally for patients admitted to intensive care units in Spain. The process consisted of four stages: translation, back translation, comparison and pilot test. There was good correspondence between the original scale and the Spanish version in 100% of the items. The participating patients assessed the relevance (content validity) and comprehensibility (face validity) of each of the items of the first Spanish version. The relevance of some of the items scored low when the scale was used in patients younger than 65 years. Conclusions We have cross‐culturally adapted the FRAIL scale, originally in English, to Spanish for its use in the critical care medical setting in Spanish‐speaking countries. Implications for Professionals Physicians and nurses can apply the new scale to all patients admitted to the intensive care units. Nursing care can be adapted according to frailty, trying to reduce the side effects of admission to these units for the most fragile patients. Reporting Method The manuscript's authors have adhered to the EQUATOR guidelines, using the COSMIN reporting guideline for studies on the measurement properties of patient‐reported outcome measures. Patient or Public Contribution In a pilot clinical study, we applied the first version of the FRAIL‐Spain scale to intensive care unit (ICU) patients. Five nurses with more than 5 years of ICU experience and five critical care physicians assessed the relevance (content validity) and comprehensibility (face validity) of the five items of the first Spanish version. Relevance was assessed using a 4‐point Likert scale ranging from 1 (no relevance) to 4 (high relevance), and comprehensibility was assessed as poor, acceptable or good. Each health professional applied the scale to three patients (total number of patients = 30) of three different age ranges (65 years) and recorded the time of application of the scale to each patient. Although the frailty scales were initially created by geriatricians to be applied to the elders, there is little experience with their application in critically ill patients of any age. Therefore, more information is needed to determine the relevance of using this scale in critical care patients. In this pilot study, we considered that nurses and critical care physicians should evaluate frailty using this adapted scale in adult patients admitted to the Intensive Care Units.

The aim of this study was to document a case of parasite co-infection in a captive Bactrian camel and to supply morphometric data of the found pathogens. It concerned a 20-year-old male animal inhabiting Sofia Zoo, Bulgaria. A decreased appetite and gastrointestinal disorders were observed in it during the summer of 2022. Improvement in the animal’s condition was achieved after the administration of antibiotics, sulfonamides, and other symptomatic medicines. However, two weeks after treatment, clinical symptoms reappeared. Then, a diarrheal fecal sample from the animal was subjected to parasitological examination by direct smear and flotation and sedimentation techniques. Multiple infections by helminths (Trichostrongylus sp., Haemonchus sp., Oesophagostomum sp., Trichuris sp., and Dicrocoelium sp.), ciliates (Buxtonella cameli), and protozoa (Eimeria cameli) were found, with E. cameli being reported for the first time in zoo conditions. Deworming led to the recovery of the general condition and appearance of the animal’s feces, but two weeks later, it died suddenly. We considered that the parasitic infection was not the direct cause of the fatal outcome, and its presence, other health disorders, and the advanced age of the animal were among the contributing factors. This case reveals the need to combine planned preventive deworming with routine parasitological diagnostics to take timely and targeted actions to protect the health of animals inhabiting zoo facilities.