28 results on '"González-Estecha, Montserrat"'
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2. Are lead, cadmium and mercury risk factors for resistant hypertension?
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Corbatón Anchuelo, Arturo, Martell Claros, Nieves, Abad Cardiel, María, García Donaire, José Antonio, Fuentes Ferrer, Manuel, Bravo Gómez, Adrián, Llorente Martín, Elena, Zamora Trillo, Angielys, Bonmatí Torres, Gonzalo, and González-Estecha, Montserrat
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- 2024
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3. Iron, vitamins and minerals status in pediatric patients with celiac diseaseand non celiac gluten sensitivity prior to diagnosis and three months later
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Bodas, Andrés, Pérez, Óscar, Martín, Paula, Junguito, Alejandro, Sánchez, Rafael, Blanco, María Victoria, and González-Estecha, Montserrat
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- 2023
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4. External quality assessment schemes for inorganic elements in the clinical laboratory: Lessons from the OELM scheme
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Arnaud, Josiane, Patriarca, Marina, Fofou-Caillierez, Béatrice Ma’atem, González-Estecha, Montserrat, Gómez, MªCarmen González, De Graaf, Irene, Patriarca, Valeria, Ropert-Bouchet, Martine, Schröer-Janssen, Liesbeth, Siebelder, Carla, Te Winkel, Marieke, Ventura Alemany, Montserrat, and Weykamp, Cas
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- 2020
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5. Blood lead in children and associations with trace elements and sociodemographic factors
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Martínez-Hernanz, Ángeles, González-Estecha, Montserrat, Blanco, María, Fuentes, Manuel, Ordóñez-Iriarte, José María, Palazón-Bru, Irene, Calvo-Manuel, Elpidio, and Bodas-Pinedo, Andrés
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- 2020
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6. The cardiomyopathy of cystic fibrosis: a modern form of Keshan disease.
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Segovia-Cubero, Javier, Ruiz-Bautista, Lorena, Maiz-Carro, Luis, Girón-Moreno, Rosa M., Prados-Sánchez, M. Concepción, Martínez-Martínez, M. Teresa, González-Estecha, Montserrat, Mingo-Santos, Susana, Gómez-Bueno, Manuel, Salas-Antón, Clara, Cavero-Gibanel, Miguel A., Pastrana-Ledesma, Miguel, García-Pavía, Pablo, Laporta-Hernández, Rosalía, Sánchez-Ortiz, David, and Alonso-Pulpón, Luis
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- 2024
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7. Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19
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Bermejo-Martin, Jesús F., González-Rivera, Milagros, Almansa, Raquel, Micheloud, Dariela, Tedim, Ana P., Domínguez-Gil, Marta, Resino, Salvador, Martín-Fernández, Marta, Ryan Murua, Pablo, Pérez-García, Felipe, Tamayo, Luis, Lopez-Izquierdo, Raúl, Bustamante, Elena, Aldecoa, César, Gómez, José Manuel, Rico-Feijoo, Jesús, Orduña, Antonio, Méndez, Raúl, Fernández Natal, Isabel, Megías, Gregoria, González-Estecha, Montserrat, Carriedo, Demetrio, Doncel, Cristina, Jorge, Noelia, Ortega, Alicia, de la Fuente, Amanda, del Campo, Félix, Fernández-Ratero, José Antonio, Trapiello, Wysali, González-Jiménez, Paula, Ruiz, Guadalupe, Kelvin, Alyson A., Ostadgavahi, Ali Toloue, Oneizat, Ruth, Ruiz, Luz María, Miguéns, Iria, Gargallo, Esther, Muñoz, Ioana, Pelegrin, Sara, Martín, Silvia, García Olivares, Pablo, Cedeño, Jamil Antonio, Ruiz Albi, Tomás, Puertas, Carolina, Berezo, Jose Ángel, Renedo, Gloria, Herrán, Rubén, Bustamante-Munguira, Juan, Enríquez, Pedro, Cicuendez, Ramón, Blanco, Jesús, Abadia, Jesica, Gómez Barquero, Julia, Mamolar, Nuria, Blanca-López, Natalia, Valdivia, Luis Jorge, Fernández Caso, Belén, Mantecón, María Ángeles, Motos, Anna, Fernandez-Barat, Laia, Ferrer, Ricard, Barbé, Ferrán, Torres, Antoni, Menéndez, Rosario, Eiros, José María, and Kelvin, David J.
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- 2020
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8. Relationship between serum selenium, sociodemographic variables, other trace elements and lipid profile in an adult Spanish population
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González-Estecha, Montserrat, Palazón-Bru, Irene, Bodas-Pinedo, Andrés, Trasobares, Elena, Palazón-Bru, Antonio, Fuentes, Manuel, Cuadrado-Cenzual, M. Ángeles, and Calvo-Manuel, Elpidio
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- 2017
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9. Probabilistic risk analysis of mercury intake via food consumption in Spain
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Moreno-Ortega, Alicia, Moreno-Rojas, Rafael, Martínez-Álvarez, Jesús Román, González Estecha, Montserrat, Castro González, Numa Pompilio, and Amaro López, Manuel Ángel
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- 2017
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10. Consensus document on the prevention of methylmercury exposure in Spain: Study group for the prevention of Me-Hg exposure in Spain (GEPREM-Hg)
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Herráiz-Martínez, Miguel Ángel, Martell-Claros, Nieves, Ordóñez-Iriarte, José Mª, Sáinz-Martín, María, Farré-Rovira, Rosaura, Martínez-Astorquiza, Txantón, García-Donaire, José Antonio, Calvo-Manuel, Elpidio, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, Mª Teresa, Martínez-García, Mª José, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, Bermejo-Barrera, Pilar, Cuadrado-Cenzual, Mª Ángeles, Gallardo-Pino, Carmen, Fuentes, María Blanco, Torres-Moreno, Miriam, Trasobares-Iglesias, Elena M., Martín, Bernardino Barceló, Arroyo-Fernández, Manuel, and Calle-Pascual, Alfonso
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- 2015
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11. Trace elements in bipolar disorder
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González-Estecha, Montserrat, Trasobares, Elena M., Tajima, Kazuhiro, Cano, Sara, Fernández, Cristina, López, José Luis, Unzeta, Belén, Arroyo, Manuel, and Fuentenebro, Filiberto
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- 2011
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12. Blood lead and cadmium levels in a six hospital employee population. PESA study, 2009
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González-Estecha, Montserrat, Trasobares, Elena, Fuentes, Manuel, Martínez, María José, Cano, Sara, Vergara, Nuria, Gaspar, María Jesús, González-Revaldería, Joaquín, Barciela, María Carmen, Bugarín, Zoila, Fernández, María Dolores, Badía, Pilar, Pintos, Concepción, González, Mónica, Guillén, José Jesús, Bermejo, Pilar, Fernández, Cristina, and Arroyo, Manuel
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- 2011
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13. Measurement of cerium in human breast milk and blood samples
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Höllriegl, Vera, González-Estecha, Montserrat, Trasobares, Elena M., Giussani, Augusto, Oeh, Uwe, Herraiz, Miguel Angel, and Michalke, Bernhard
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- 2010
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14. Determinación de plomo y cadmio en sangre y su relación con fuentes de exposición. Estudio PESA, 2008
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González-Estecha, Montserrat, Trasobares Iglesias, Elena, Cano Escudero, Sara, Oliván Osambela, Pilar, Fuentes Ferrer, Manuel, Fernández Pérez, Cristina, Martínez García, María José, García González, Ángel Luis, Gaspar Blázquez, María Jesús, González Revaldería, Joaquín, Barciela Alonso, María Carmen, Herbello Hermelo, Paloma, Bermejo Barrera, Pilar, Guillén Pérez, José Jesús, Miravalles González, Elena, and Arroyo Fernández, Manuel
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- 2009
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15. Effects of angiotensin-converting enzyme inhibitors (ACE i) on zinc metabolism in patients with heart failure
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Trasobares, Elena, Corbatón, Arturo, González-Estecha, Montserrat, Lopez-Colón, Jose Luis, Prats, Pilar, Olivan, Pilar, Sánchez, Jose Antonio, and Arroyo, Manuel
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- 2007
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16. The different faces of inorganic elements in SARS-CoV-2 infection.
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Arnaud, Josiane, González-Estecha, Montserrat, and Skalny, Anatoly
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SARS-CoV-2 ,INFECTION ,POISONS - Published
- 2022
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17. Documento de consenso sobre la prevención de la exposición al metilmercurio en España.
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Herráiz-Martínez, Miguel Ángel, Martell-Claros, Nieves, Ordóñez-Iriarte, José Ma, Sáinz-Martín, María, Farré-Rovira, Rosaura, Martínez-Astorquiza, Txantón, García-Donaire, José Antonio, Calvo-Manuel, Elpidio, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, María Teresa, Martínez-García, María José, Moreno-Rojas, Rafael, Salas-Salvadó, Jordi, and Bermejo-Barrera, Pilar
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METHYLMERCURY , *MERCURY content of fish , *SPANIARDS , *BIOMARKERS , *COST effectiveness , *HEALTH , *PHYSIOLOGY - Abstract
The beneficial effects of fish consumption in both children and adults are well known. However, the intake of methylmercury, mainly from contaminated fish and shellfish, can have adverse health effects. The study group on the prevention of exposure to methylmercury (GEPREM-Hg), made up of representatives from different Spanish scientific societies, has prepared a consensus document in a question and answer format, containing the group's main conclusions, recommendations and proposals. The objective of the document is to provide broader knowledge of factors associated with methylmercury exposure, its possible effects on health among the Spanish population, methods of analysis, interpretation of the results and economic costs, and to then set recommendations for fish and shellfish consumption. The group sees the merit of all initiatives aimed at reducing or prohibiting the use of mercury as well as the need to be aware of the results of contaminant analyses performed on fish and shellfish marketed in Spain. In addition, the group believes that biomonitoring systems should be set up in order to follow the evolution of methylmercury exposure in children and adults and perform studies designed to learn more about the possible health effects of concentrations found in the Spanish population, taking into account the lifestyle, eating patterns and the Mediterranean diet. [ABSTRACT FROM AUTHOR]
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- 2015
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18. Metilmercurio: Recomendaciones existentes; métodos de análisis e interpretación de resultados; evaluación económica.
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Martínez-García, María José, Trasobares-Iglesias, Elena M., Bermejo-Barrera, Pilar, Ordóñez-Iriarte, José María, Llorente-Ballesteros, María Teresa, Prieto-Menchero, Santiago, Guillén-Pérez, José Jesús, Martell-Claros, Nieves, Cuadrado-Cenzual, María Ángeles, Rubio-Herrera, Miguel Ángel, Martínez-Álvarez, Jesús Román, Calvo-Manuel, Elpidio, Farré-Rovira, Rosaura, Herráiz-Martínez, Miguel Ángel, Bretón Lesmes, Irene, García-Donaire, José Antonio, Sáinz-Martín, María, and Martínez-Astorquiza, Txantón
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METHYLMERCURY , *ECONOMICS , *MERCURY content of fish , *BIOMARKERS , *COST effectiveness , *CHELATION therapy - Abstract
The beneficial effects of fish consumption are well-known. Nevertheless, there is worldwide concern regard methylmercury concentrations in fish, which is why many countries such as the United States, Australia, New Zealand, Canada and numerous European countries have made fish consumption recommendations for their populations, particularly vulnerable groups, in order to México methylmercury intake. Blood and hair are the best biological samples for measuring methylmercury. The most widely-used method to analyse methylmercury is cold vapor atomic absorption spectrometry, although there are also direct methods based on the thermal decomposition of the sample. In recent years, the number of laboratories that measure mercury by inductively coupled plasma mass spectrometry has increased. In addition, the different kinds of mercury can be distinguished by coupling chromatography methods of separation. Laboratories that analyse mercury in biological samples need to participate in external quality control programmes. Even if mercury emissions are reduced, mercury may remain in the environment for many years, so dietary recommendations are fundamental in order to reduce exposure. It is necessary to propose public health measures aimed at decreasing mercury exposure and to evaluate the benefits of such measures from the economic and social standpoints. [ABSTRACT FROM AUTHOR]
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- 2015
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19. Efectos sobre la salud del metilmercurio en niños y adultos; estudios nacionales e internacionales.
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Rubio-Herrera, Miguel Ángel, Martell-Claros, Nieves, Trasobares-Iglesias, Elena M., Ordóñez-Iriarte, José Ma, Guillen-Pérez, José Jesús, Herráiz-Martínez, Miguel Ángel, García-Donaire, José Antonio, Farré-Rovira, Rosaura, Calvo-Manuel, Elpidio, Martínez-Álvarez, Jesús Román, Llorente-Ballesteros, Ma Teresa, Sáinz-Martín, María, Martínez-Astorquiza, Txantón, Martínez-García, Ma José, Bretón Lesmes, Irene, Cuadrado-Cenzual, Ma Ángeles, Prieto-Menchero, Santiago, and Gallardo-Pino, Carmen
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PHYSIOLOGICAL effects of methylmercury compounds , *METHYLMERCURY , *CHILDREN'S health , *CARDIOVASCULAR diseases , *PRENATAL exposure delayed effects , *FISH research - Abstract
The benefit of fish consumption in children and adults is well-known. However, it has been pointed out that excessive methylmercury intake due to consumption of contaminated fish leads to neurological toxicity in children, affecting cognitive function, memory, visual-motor function and language. After the intoxications in Minamata and Iraq, wide-ranging epidemiological studies were carried out in New Zealand, the Faroe Islands and the Seychelles and international recommendations were established for fish consumption in pregnant women and small children. In Spain, the Childhood and Environmental project (INMA, its Spanish acronym) has studied the effects of diet and the environment on fetal and childhood development in different geographic areas of Spain. National and international sudies have demonstrated that mercury concentrations are mainly dependent on fish consumption, although there are variations among countries which can be explained not only by the levels of fish consumption, but also by the type or species of fish that is consumed, as well as other factors. Although the best documented adverse effects of methylmercury are the effects on nervous sytem development in fetuses and newborns, an increasing number of studies indicate that cognitive function, reproduction and, especially, cardiovascular risk in the adult population can also be affected. However, more studies are necessary in order to confirm this and establish the existance of a causal relationship. [ABSTRACT FROM AUTHOR]
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- 2014
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20. Exposición al metilmercurio en la población general; toxicocinética; diferencias según el sexo, factores nutricionales y genéticos.
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González-Estecha, Montserrat, Bodas-Pinedo, Andrés, Guillén-Pérez, José Jesús, Rubio-Herrera, Miguel Ángel, Ordóñez-Iriarte, José Ma, Trasobares-Iglesias, Elena M., Martell-Claros, Nieves, Martínez-Álvarez, Jesús Román, Farré-Rovira, Rosaura, Herráiz-Martínez, Miguel Angel, Martínez-Astorquiza, Txantón, Calvo-Manuel, Elpidio, Sáinz-Martín, María, Bretón-Lesmes, Irene, Prieto-Menchero, Santiago, Llorente-Ballesteros, Ma Teresa, Martínez-García, Ma José, Salas-Salvadó, Jordi, Bermejo-Barrera, Pilar, and García-Donaire, José Antonio
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METHYLMERCURY , *TOXINS , *GENDER studies , *NUTRITION , *GENETICS , *MERCURY in the body , *UNSATURATED fatty acids - Abstract
Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems. The factors that determine the existance of adverse effects, as well as their severity are, among others: the chemical form of mercury (elemental, inorganic, organic), dosis, age, period of exposure, pathways of exposure and environmental, nutritional and genetic factors. In the aquatic cycle of mercury, once it has been deposited, it is transformed into methylmercury due to the action of certain sulphate-reducing bacteria, which bioaccumulates in the aquatic organisms and moves into the food chain. The methylmercury content of large, long-lived fish such as swordfish, shark, tuna or marlin, is higher. Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish. Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish. Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta. The intake of certain dietary components such as polyunsaturated fatty acids, selenium, fiber, thiol compounds, certain phytochemicals and other nutrients can modify methylmercury bioaccesibility and its toxicity. Apart from environmental factors, genetic factors can influence mercury toxicity and explain part of the individual vulnerability. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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21. Cerium in human milk samples and its transfer from blood to milk: Is there an elevated nutritional risk for breast-fed babies?
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Michalke, Bernhard, González-Estecha, Montserrat, Trasobares, Elena M., Herraiz, Miguel Angel, Giussani, Augusto, Oeh, Uwe, and Höllriegl, Vera
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FISSION products , *CERIUM , *BREAST milk , *FIBROSIS , *NEWBORN infant nutrition , *BIOLOGICAL monitoring , *INDUCTIVELY coupled plasma mass spectrometry ,NEWBORN infant health - Abstract
The general population is increasingly exposed to cerium (Ce), which is contained in industrial products or is present as nuclear Ce fission products. Some studies suggested a link between elevated Ce levels and endomyocardial fibrosis. Since breast milk is the optimal, and directly after birth, usually the sole nutrition for newborns, exposure of females to Ce and its transfer to infants by breast-feeding is of concern in neonate protection. Consequently, the transfer rate of Ce from blood to breast milk is of interest for elucidating the Ce exposure of infants. Biomonitoring of paired serum and breast milk samples provides such information about Ce transfer to human milk. Therefore, this study is aimed at clarification of the relationship between Ce in human milk and serum from respective mothers for elucidating Ce enrichment in human milk with possible nutritional risk for newborns. As a prerequisite a strictly quality-controlled Ce determination method applicable to very low Ce concentration was developed, and its figures of merit were determined and found to be sufficient for our purpose. It turned out that Ce concentration in milk from Munich (Germany) and Madrid (Spain) showed a median of 13 ng/L. Ce concentrations in serum were at limit of quantification (LOQ) 10 ng/L (Munich) or 21.6-70.3 ng/L (Madrid), suggesting a higher Ce intake in Madrid. No enrichment from blood to milk was seen, and no elevated nutritional risk for breast-fed babies from Ce was found. Ce in serum, but not in milk, could indicate environmental Ce. [ABSTRACT FROM AUTHOR]
- Published
- 2012
22. Effects of angiotensin-converting enzyme inhibitors (ACEi) on zinc metabolism in patients with heart failure.
- Author
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Trasobares, Elena, Corbatón, Arturo, González-Estecha, Montserrat, Lopez-Colón, Jose Luis, Prats, Pilar, Olivan, Pilar, Sánchez, Jose Antonio, and Arroyo, Manuel
- Subjects
HEART diseases ,HEART failure ,CHEMICAL inhibitors ,CARDIAC arrest - Abstract
Abstract: The aim of this study is to investigate the effects of angiotensin-converting enzyme (ACE) inhibitors and furosemide on zinc metabolism by assessing serum zinc and urine levels in hospitalized subjects. We recruited 11 patients with heart failure from the Internal Medicine Department; these patients had been hospitalized less than 72h before. Heart failure was defined using clinical and radiological signs. Serum zinc concentrations were measured using an air/acetylene flame atomic absorption spectrophotometer. Urine zinc levels were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Data were obtained from the 11 patients and 24 healthy controls matched for age and sex. Results indicate higher urine zinc levels and lower concentrations of zinc in serum in heart failure patients vs matched controls (p<0.05). This study suggests that treating heart failure patients with ACE inhibitors may result in zinc deficiency. [Copyright &y& Elsevier]
- Published
- 2007
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23. Analytical performance specifications for trace elements in biological fluids derived from six countries federated external quality assessment schemes over 10 years.
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Arnaud J, Weykamp C, Wenzel R, Patriarca M, González-Estecha M, Janssen L, Fofou-Caillierez MB, Alemany MV, Patriarca V, de Graaf I, Persoons R, Panadès M, China B, Winkel MT, van der Vuurst H, and Thelen M
- Abstract
Objectives: This article defines analytical performance specifications (APS) for evaluating laboratory proficiency through an external quality assessment scheme., Methods: Standard deviations for proficiency assessment were derived from Thompson's characteristic function applied to robust data calculated from participants' submissions in the Occupational and Environmental Laboratory Medicine (OELM) external quality assurance scheme for trace elements in serum, whole blood and urine. Characteristic function was based on two parameters: (1) β - the average coefficient of variation (CV) at high sample concentrations; (2) α - the average standard deviation (SD) at low sample concentrations. APSs were defined as 1.65 standard deviations calculated by Thompson's approach. Comparison between OELM robust data and characteristic function were used to validate the model., Results: Application of the characteristic function allowed calculated APS for 18 elements across three matrices. Some limitations were noted, particularly for elements (1) with no sample concentrations near analytical technique limit of detection; (2) exhibiting high robust CV at high concentration; (3) exhibiting high analytical variability such as whole blood Tl and urine Pb; (4) with an unbalanced number of robust SD above and under the characteristic function such as whole blood Mn and serum Al and Zn., Conclusions: The characteristic function was a useful means of deriving APS for trace elements in biological fluids where biological variation data or outcome studies were not available. However, OELM external quality assurance scheme data suggests that the characteristic functions are not appropriate for all elements., (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
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- 2024
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24. [Economic Appraisal of the Impact of the Ban on the Use of Lead in Gasoline on the Intellectual Quotient of 7-8 Years Old in the Community of Madrid].
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Ordóñez-Iriarte JM, Guillén-Pérez JJ, Bodas-Pinedo A, Aparicio-Madre MI, Martínez-García MJ, González-Estecha M, and Cabasés-Hita JM
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- Child, Cross-Sectional Studies, Efficiency, Employment economics, Environmental Exposure economics, Environmental Exposure legislation & jurisprudence, Female, Health Impact Assessment, Health Policy legislation & jurisprudence, Humans, Intelligence Tests, Male, Spain, Environmental Exposure prevention & control, Environmental Pollutants blood, Environmental Pollutants toxicity, Gasoline, Health Policy economics, Intelligence, Lead blood, Lead toxicity
- Abstract
Background: The repercussions on health of public policies are hard to assess from an economic point of view, which is why this is rarely done. The purpose of this study was to financially quantify the benefits of reducing blood lead levels in children aged 7-8 years in the Community of Madrid (Spain) as a result of the ban on the use of lead in gasoline., Methods: The decrease the intellectual quotient (IQ) points was calculated through two studies on children aged 7-8 years according to their blood lead levels. A geometric mean of 3.8 μg/dl was obtained in the 1995 study and of 0.9 μg/dl in the 2010 study. The net increase in IQ was measured in terms of productivity gained throughout the working life as per the methods of Schwartz and Salkever., Results: The decrease in blood lead levels in these children prevented a loss of between 135,391 and 144,153 IQ points; the current economic valuation of these points in terms of the productivity gained throughout the working life of this cohort of children was estimated to fall within the 626.4m- 865.4m range (2009)., Conclusions: The figures of the economic benefits derived from the decision to ban leaded gasoline are very high.
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- 2015
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25. [Consensus document on the prevention of exposure to methylmercury in Spain].
- Author
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González-Estecha M, Bodas-Pinedo A, Guillén-Pérez JJ, Rubio-Herrera MÁ, Martínez-Álvarez JR, Herráiz-Martínez MÁ, Martell-Claros N, Ordóñez-Iriarte JM, Sáinz-Martín M, Farré-Rovira R, Martínez-Astorquiza T, García-Donaire JA, Calvo-Manuel E, Bretón-Lesmes I, Prieto-Menchero S, Llorente-Ballesteros MT, Martínez-García MJ, Moreno-Rojas R, Salas-Salvadó J, Bermejo-Barrera P, Cuadrado-Cenzual MÁ, Gallardo-Pino C, Blanco Fuentes M, Torres-Moreno M, Trasobares-Iglesias EM, Barceló Martín B, Arroyo-Fernández M, and Calle-Pascual A
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- Adult, Child, Consensus, Diet, Mediterranean, Food Contamination analysis, Humans, Spain epidemiology, Methylmercury Compounds adverse effects, Methylmercury Compounds analysis, Seafood adverse effects, Seafood analysis
- Abstract
The beneficial effects of fish consumption in both children and adults are well known. However, the intake of methylmercury, mainly from contaminated fish and shellfish, can have adverse health effects. The study group on the prevention of exposure to methylmercury (GEPREM-Hg), made up of representatives from different Spanish scientific societies, has prepared a consensus document in a question and answer format, containing the group's main conclusions, recommendations and proposals. The objective of the document is to provide broader knowledge of factors associated with methylmercury exposure, its possible effects on health among the Spanish population, methods of analysis, interpretation of the results and economic costs, and to then set recommendations for fish and shellfish consumption. The group sees the merit of all initiatives aimed at reducing or prohibiting the use of mercury as well as the need to be aware of the results of contaminant analyses performed on fish and shellfish marketed in Spain. In addition, the group believes that biomonitoring systems should be set up in order to follow the evolution of methylmercury exposure in children and adults and perform studies designed to learn more about the possible health effects of concentrations found in the Spanish population, ta king into account the lifestyle, eating patterns and the Mediterranean diet., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
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- 2014
- Full Text
- View/download PDF
26. [Methylmercury: existing recommendations; methods of analysing and interpreting the results; economic evaluation].
- Author
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González-Estecha M, Bodas-Pinedo A, Martínez-García MJ, Trasobares-Iglesias EM, Bermejo-Barrera P, Ordóñez-Iriarte JM, Llorente-Ballesteros MT, Prieto-Menchero S, Guillén-Pérez JJ, Martell-Claros N, Cuadrado-Cenzual MÁ, Rubio-Herrera MÁ, Martínez-Álvarez JR, Calvo-Manuel E, Farré-Rovira R, Herráiz-Martínez MÁ, Bretón Lesmes I, García-Donaire JA, Sáinz-Martín M, Martínez-Astorquiza T, Gallardo-Pino C, Moreno-Rojas R, Salas-Salvadó J, Blanco Fuentes M, Arroyo-Fernández M, and Calle Pascual A
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- Animals, Cost-Benefit Analysis, Fishes, Food Contamination analysis, Food Contamination economics, Humans, Methylmercury Compounds economics, Methylmercury Compounds analysis, Methylmercury Compounds toxicity
- Abstract
The beneficial effects of fish consumption are well- known. Nevertheless, there is worldwide concern regard methylmercury concentrations in fish, which is why many countries such as the United States, Australia, New Zealand, Canada and numerous European countries have made fish consumption recommendations for their populations, particularly vulnerable groups, in order to México methylmercury intake. Blood and hair are the best biological samples for measuring methylmercury. The most widely-used method to analyse methylmercury is cold vapor atomic absorption spectrometry, although there are also direct methods based on the thermal decomposition of the sample. In recent years, the number of laboratories that measure mercury by inductively coupled plasma mass spectrometry has increased. In addition, the different kinds of mercury can be distinguished by coupling chromatography methods of separation. Laboratories that analyse mercury in biological samples need to participate in external quality control programmes. Even if mercury emissions are reduced, mercury may remain in the environment for many years, so dietary recommendations are fundamental in order to reduce exposure. It is necessary to propose public health measures aimed at decreasing mercury exposure and to evaluate the benefits of such measures from the economic and social standpoints., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
27. [Methylmercury exposure in the general population; toxicokinetics; differences by gender, nutritional and genetic factors].
- Author
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González-Estecha M, Bodas-Pinedo A, Guillén-Pérez JJ, Rubio-Herrera MÁ, Ordóñez-Iriarte JM, Trasobares-Iglesias EM, Martell-Claros N, Martínez-Álvarez JR, Farré-Rovira R, Herráiz-Martínez MÁ, Martínez-Astorquiza T, Calvo-Manuel E, Sáinz-Martín M, Bretón-Lesmes I, Prieto-Menchero S, Llorente-Ballesteros MT, Martínez-García MJ, Salas-Salvadó J, Bermejo-Barrera P, García-Donaire JA, Cuadrado-Cenzual MÁ, Gallardo-Pino C, Moreno-Rojas R, Arroyo-Fernández M, and Calle-Pascual A
- Subjects
- Aging, Animals, Female, Fishes, Humans, Male, Mercury metabolism, Mercury pharmacokinetics, Seafood, Sex Characteristics, Toxicokinetics, Mercury Poisoning genetics, Mercury Poisoning pathology, Methylmercury Compounds pharmacokinetics, Methylmercury Compounds toxicity, Nutritional Status
- Abstract
Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems. The factors that determine the existance of adverse effects, as well as their severity are, among others: the chemical form of mercury (elemental, inorganic, organic), dosis, age, period of exposure, pathways of exposure and environmental, nutritional and genetic factors. In the aquatic cycle of mercury, once it has been deposited, it is transformed into methylmercury due to the action of certain sulphate-reducing bacteria, which bioaccumulates in the aquatic organisms and moves into the food chain. The methylmercury content of large, long-lived fish such as swordfish, shark, tuna or marlin, is higher. Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish. Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish. Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta. The intake of certain dietary components such as polyunsaturated fatty acids, selenium, fiber, thiol compounds, certain phytochemicals and other nutrients can modify methylmercury bioaccesibility and its toxicity. Apart from environmental factors, genetic factors can influence mercury toxicity and explain part of the individual vulnerability., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
28. [The effects of methylmercury on health in children and adults; national and international studies].
- Author
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González-Estecha M, Bodas-Pinedo A, Rubio-Herrera MÁ, Martell-Claros N, Trasobares-Iglesias EM, Ordóñez-Iriarte JM, Guillén-Pérez JJ, Herráiz-Martínez MÁ, García-Donaire JA, Farré-Rovira R, Calvo-Manuel E, Martínez-Álvarez JR, Llorente-Ballesteros MT, Sáinz-Martín M, Martínez-Astorquiza T, Martínez-García MJ, Bretón Lesmes I, Cuadrado-Cenzual MÁ, Prieto-Menchero S, Gallardo-Pino C, Moreno-Rojas R, Bermejo-Barrera P, Torres-Moreno M, Arroyo-Fernández M, and Calle-Pascual A
- Subjects
- Adult, Animals, Female, Humans, Infant, Infant, Newborn, Mercury Poisoning etiology, Methylmercury Compounds poisoning, Pregnancy, Seafood analysis, Fishes, Mercury Poisoning epidemiology, Methylmercury Compounds toxicity, Seafood adverse effects
- Abstract
The benefit of fish consumption in children and adults is well-known. However, it has been pointed out that excessive methylmercury intake due to consumption of contaminated fish leads to neurological toxicity in children, affecting cognitive function, memory, visual-motor function and language. After the intoxications in Minamata and Iraq, wide-ranging epidemiological studies were carried out in New Zealand, the Faroe Islands and the Seychelles and international recommendations were established for fish consumption in pregnant women and small children. In Spain, the Childhood and Environmental project (INMA, its Spanish acronym) has studied the effects of diet and the environment on fetal and childhood development in different geographic areas of Spain. National and international sudies have demonstrated that mercury concentrations are mainly dependent on fish consumption, although there are variations among countries which can be explained not only by the levels of fish consumption, but also by the type or species of fish that is consumed, as well as other factors. Although the best documented adverse effects of methylmercury are the effects on nervous sytem development in fetuses and newborns, an increasing number of studies indicate that cognitive function, reproduction and, especially, cardiovascular risk in the adult population can also be affected. However, more studies are necessary in order to confirm this and establish the existance of a causal relationship., (Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
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