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The aim of the study was to examine the correlations between markers of chronic systemic inflammation (CHD), inflammatory endothelial activation, blood lipid spectrum, antioxidant system, liver and heart function in patients with stable coronary heart disease in combination with non-alcoholic fatty liver disease. The study involved 110 people with coronary heart disease: stable angina pectoris, II FC, CH 0-I in combination with non-alcoholic fatty liver disease aged 40-69 years. The analysis of indicators of a lipid spectrum of blood is made, studied the level of ceruloplasmin, cytokines (IL-6, TNFα, IL-10), circulating endothelial microparticles (CEM) CD32+ CD40+ in the blood, the expression of kappa B inhibitor mRNA gene α (IkBα) of nuclear kappa B transcription factor in peripheral blood mononuclear cells was studied and echocardiography, liver ultrasound with color and pulse Doppler imaging were performed (blood flow velocity in portal and hepatic veins was established). The relationship between the variables was then studied by correlation analysis. Conclusion. The correlation analysis established the relationship between the expression of mRNA IkBα nuclear transcription factor Kappa B with chronic systemic inflammation of low intensity, lipid metabolism with dysfunctional changes in blood flow in the liver (blood flow velocity in the portal vein), we can conclude that chronic systemic inflammation at the molecular genetic level plays an important role in the development of both coronary heart disease and nonalcoholic fatty liver disease and confirms the common pathogenetic mechanism of this comorbid pathology.

The dynamics of a bilayer system filling a rectangular cuvette subjected to external heating is studied. The influence of two types of thermal exposure on the flow pattern and on the dynamic contact angle is analyzed. In particular, the cases of local heating from below and distributed thermal load from the lateral walls are considered. The simulation is carried out within the frame of a two-sided evaporative convection model based on the Boussinesq approximation. A benzine–air system is considered as reference system. The variation in time of the contact angle is described for both heating modes. Under lateral heating, near-wall boundary layers emerge together with strong convection, whereas the local thermal load from the lower wall results in the formation of multicellular motion in the entire volume of the fluids and the appearance of transition regimes followed by a steady-state mode. The results of the present study can aid the design of equipment for thermal coating or drying and the development of methods for the formation of patterns with required structure and morphology. [ABSTRACT FROM AUTHOR]

The influence of the moisture content on the CO2 emission from peat soils of palsa mires in the discontinuous permafrost area was studied in the north of Western Siberia (Nadym region). The СО2 flux was measured in Histic Cryosols of permafrost peatlands (palsas) and Fibric Histosols of surrounding bog using the closed chamber method for four years at the peak of the growing season (August). Despite a significant difference in the soil moisture (34.8 ± 13.2 and 56.2 ± 2.1% on average), no significant difference in the CO2 emission from these ecosystems was found in any of the observation years; the rates of emission averaged 199.1 ± 90.1 and 182.1 ± 85.1 mg CO2 m–2 × h–1, respectively. Experimental wetting or drying (with a twofold difference in the moisture content) of peat soils at the two sites via their transplantation to a different position showed no significant effect on the CO2 emission even three years after the beginning of the experiment. The absence of significant differences in the CO2 flux between the two different ecosystems was explained by the presence of permafrost and the influence of many multidirectional factors mitigating changes in the CO2 production by soils. An increased CO2 emission from the peat soils of bogs was possible due to the additional contribution of the methanotrophic barrier and the lateral runoff of dissolved CO2 over the permafrost table from the palsa toward the surrounding bog. The absence of response of the CO2 emission to a significant change in the soil moisture content may be indicative of a wide optimum of this characteristic for the microbiological activity of peat soils in the studied region. The obtained data suggest that, while studying CO2 fluxes in cryogenic soils of hydromorphic landscapes, it is necessary to take into account not only biogenic sources, but also other factors, often of a physical nature, affecting the balance of CO2 fluxes and CO2 emission from soils. [ABSTRACT FROM AUTHOR]

Background. Although today primary hyperparathyroidism and cancers are considered the main factors of hypercalcemia (HC), the latter is quite often detected in various endocrinopathies. According to modern data, ionized calcium (Ca2+) is an intracellular mediator in the functioning of enzymes and hormones. All this determines the importance of finding out the features of the associations between HC and biochemical indicators in various endocrine disorders, which was the purpose of this study. Materials and methods. Retrospectively, according to the medical histories of 537 patients with detected HC, who were treated at the endocrinology clinic of the V. Danilevsky Institute for the Endocrine Pathology Problems in 2020–2021, we have analyzed the features of correlations between HC (by the content of Ca2+) and the levels of phosphorus (P), total protein (TP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in various endocrine pathologies. Results. A significant difference between the spectrum and degree of probability of associations was found even within the limits of one type of pathological conditions. In the group with hypothyroidism, there was an inverse correlation of HC with P (p < 0.01) and a highly probable correlation with AST (p < 0.001). At the same time, a direct association with P (p < 0.01) and an inverse correlation with TP (p < 0.001), AST (p < 0.001) and ALT (p < 0.01) was revealed in case of Graves’ disease. The following data were obtained for tumors of endocrine organs: nontoxic multinodular goiter — direct with P (p < 0.001) and inverse with TP (p < 0.001) and ALT (p < 0.01); thyroid cancer — direct correlation with P (p < 0.01) and inverse highly probable with TP (p < 0.001) and ALT (p < 0.001); nodular pathology of the adrenal glands — direct correlation with TP (p < 0.01) and inverse with AST (p < 0.01) and ALT (p < 0.001). In diabetes mellitus, only an inverse correlation with P was found (p < 0.01). There was an inverse correlation with P (p < 0.01) and TP (p < 0.001), and a direct one with ALT (p < 0.001) in primary hyperparathyroidism. Conclusions. Metabolic disorders in the presence of hypercalcemia in patients with various endocrine pathologies have their own characteristics. The nature of revealed correlations between ionized calcium and biochemical parameters in terms of various endocrine diseases must be taken into account when developing a therapeutic strategy for patients with hypercalcemia. [ABSTRACT FROM AUTHOR]