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For the assessment of seismic effects on RC buildings, the real structural condition has to be modelled as accurately as possible. Medical facilities and hospitals have to resist seismic actions and remain operational after seismic events. For this reason, a detailed seismic vulnerability assessment of a hospital building located in Orihuela, Spain, is presented in this paper using a combination of field monitoring data and numerical analysis. Ambient noise measurements from field monitoring using Raspberry Shake-based sensors are used to capture dynamic characteristics that describe the building behaviour. Data from these sensors were used to update and refine the finite element model of the structure for a detailed analysis of the building's seismic performance. The different analytical procedures included both elastic and inelastic modelling, as well as static and dynamic assessments, to provide an exhaustive evaluation of the building's behaviour under seismic loads. In the numerical model, the effect of masonry infill walls is considered, taking into account detailed material properties and structural configurations. Furthermore, the study carefully selects ground motion records representing two limit states—Damage Limitation (DL) and Severe Damage (SD)—to conduct an extensive seismic analysis. In each limit state applied to the structure, there are 14 bidirectional ground motions with components alternately directed along the two principal directions of the building. This analysis evaluated the structural response, focusing on torsional effects, inter-storey drift ratios, and the seismic performance of individual components. The results were compared to other analysis types, considering both overall and localised behaviour, to determine the reliability of different approaches. The findings support the idea that field monitoring data should be combined with advanced modelling techniques to achieve a more accurate evaluation of the building's seismic vulnerability, considering bidirectional effects. [ABSTRACT FROM AUTHOR]

Probabilistic Seismic Hazard Analysis (PSHA) typically requires tectonic b-values and seismic activity rates using declustered catalogues to compute the annual probability of exceedance of a given ground motion (for example, the Peak Ground Acceleration or PGA). In this work, we propose a methodology that includes the spatially-gridded time-dependent b-value and activity rate computation using seismic clusters in PSHA calculations. To account for the the spatial variability and the relationship of the earthquakes with the seismic sources, we incorporate the distance from the grid cell to the closest fault and the epicentre's uncertainty into the smoothing kernel as the average distance and the variance, respectively. To illustrate this methodology, we selected two scenarios, one in central Italy where L'Aquila earthquake happened and one in south-eastern Spain, where several earthquakes with a moment magnitude (Mw) greater than 4.0 have taken place over the last 30 years, including two earthquakes with greater than or equal to 5.0 Mw. We compared three different seismic activity models based on the parameters considered in the calculations (distance from spatial cells to faults and epicentral distance uncertainty) and we defined and calculated the changes of the annual probability of exceedance for a given background PGA value. The results reveal an oscillation of the changes of the annual probability of exceedance in the proximity of the occurrence of significant events. The increase is more significant in high seismicity areas, such as Italy, but it is no so evident in moderate seismicity regions as Spain. However, we have observed how, for moderate to low seismicity regions, the use of a non-declustered catalogue can be appropriate when computing time-dependent PSHA, as in the case of Spain. [ABSTRACT FROM AUTHOR]

Spatial mapping is one of the most useful methods to display information about the seismic parameters of a certain area. As in b -value time series, there is a certain arbitrariness regarding the function selected as smoothing kernel (which plays the same role as the window size in time series). We propose a new method for the calculation of the smoothing kernel as well as its parameters. Instead of using the spatial cell-event distance we study the distance between events (event-event distance) in order to calculate the smoothing function, as this distance distribution gives information about the event distribution and the seismic sources. We examine three different scenarios: two shallow seismicity settings and one deep seismicity catalog. The first one, Italy, allows calibration and showcasing of the method. The other two catalogs: the Lorca region (Spain) and Vrancea County (Romania) are examples of different function fits and data treatment. For these two scenarios, the prior to earthquake and after earthquake b -value maps depict tectonic stress changes related to the seismic settings (stress relief in Lorca and stress build-up zone shifting in Vrancea). This technique could enable operational earthquake forecasting (OEF) and tectonic source profiling given enough data in the time span considered. [ABSTRACT FROM AUTHOR]

Many previous research studies have shown how local and even regional earthquakes can significantly affect the release of radon in the soil. The aim of this work is to investigate the relationship between radon measurements and the daily seismic activity rate and develop a methodology that allows estimating the seismic activity rate using only radon measurements. To carry out this study, the earthquake catalogue of the Vrancea region (Romania) has been used to estimate the daily seismic activity rate during a given time period, in which radon measurements were also recorded, from January 2016 to September 2020. The Vrancea zone represents the most active seismic zone in Europe and is located on the eastern edge of the strongly bent Carpathian arc. In the case of the radon measurements, seasonal behaviours and linear trends due to non-seismic factors have been identified and subsequently removed. The discrete wavelet transform has been used to analyse the radon signal at two different scales: long and short periods. From the analysis carried out on a long-period scale, an approximate linear relationship has been obtained between the radon series and the daily seismic activity rate, which provides insights into the behaviour of the seismic activity in the study region with only the radon information. In addition, the study reveals certain characteristics that could be used as precursors of earthquakes at different scales: weeks in the case of the estimated daily seismic activity rate, and days in the case of the short-period signal obtained by the wavelet analysis. The results obtained for this region allow us to hope that the analysis of the radon time series can become an effective complement to the conventional seismic analysis used in operational earthquake forecasting. [ABSTRACT FROM AUTHOR]

Infective endocarditis is a rather uncommon disease, but it has significant mortality rates in the pediatric population (5% to 10%). We report a case of an infant patient with multiple vegetation in the tricuspid valve secondary to infective endocarditis caused by Corynebacterium diphtheriae. A tricuspid valvuloplasty was performed with a fenestrated autologous pericardium patch, providing satisfactory outcomes. This technique is simple, innovative, effective, and it could be applied in similar cases. [ABSTRACT FROM AUTHOR]

A daily rainfall database covering the Júcar and Segura river basin authorities (east Iberian Peninsula, Spain) with high spatial density without gaps (890 series) has been created for the complete period 1955–2016. This has allowed a trend analysis of precipitation and dry/wet spells with a better spatial detail and coverage of key headwaters sectors than previous studies in this area. Results show significant negative trends for precipitation prevailing in Júcar area (an annual average loss of 51 mm), especially towards its north interior headwaters. For this last one the annual loss exceeds 200 mm (20% of precipitation). By contrast, certain pre‐littoral sectors and most of the Segura area are remaining out of these negative trends (some local positive trends). However, the dry spells length and the number of dry days have increased in a generalized way (Júcar and Segura basins) with rainfall concentration in time and space. The decrease of moderate rainfall with greater precipitation effectiveness and weight in the key interior headwaters is the most significant. On the contrary, there has been an increase in extreme torrential rainfall (with poor effectiveness and high risk) at points on the coast and pre‐littoral towards south of the region. These results are linked to a change in the frequency of three basic synoptic types identified in the region as rainfall origin. A spatially dense daily rainfall database covering the CHJ and CHS river basin authorities (Spain) without gaps has been created for the period 1955–2016. A trend analysis has been performed on precipitation and dry/wet spells. Negative rainfall trends prevail in CHJ area especially towards the headwaters. Dry spells length and the rainfall concentration have generally increased (CHJ, CHS). These results are linked to synoptic changes as loss of Atlantic origin rainfall and summer storms. [ABSTRACT FROM AUTHOR]

The Regional Atmospheric Modeling System (RAMS) is being used for different and diverse purposes, ranging from atmospheric and dispersion of pollutants forecasting to agricultural meteorology and ecological modelling as well as for hydrological purposes, among others. The current paper presents a comprehensive assessment of the RAMS forecasts, comparing the results not only with observed standard surface meteorological variables, measured at FLUXNET stations and other portable and permanent weather stations located over the region of study, but also with non-standard observed variables, such as the surface energy fluxes, with the aim of evaluating the surface energy budget and its relation with a proper representation of standard observations and key physical processes for a wide range of applications. In this regard, RAMS is assessed against in-situ surface observations during a selected period within July 2011 over Eastern Spain. In addition, the simulation results are also compared with different surface remote sensing data derived from the Meteosat Second Generation (MSG) Spinning Enhanced Visible and Infrared Imager (SEVIRI) (MSG-SEVIRI) as well as the uncoupled Land Surface Models (LSM) Global Land Data Assimilation System (GLDAS). Both datasets complement the available in-situ observations and are used in the current study as the reference or ground truth when no observations are available on a selected location. Several sensitivity tests have been performed involving the initial soil moisture content, by adjusting this parameter in the vertical soil profile ranging from the most superficial soil layers to those located deeper underground. A refined adjustment of this parameter in the initialization of the model has shown to better represent the observed surface energy fluxes. The results obtained also show an improvement in the model forecasts found in previous studies in relation to standard observations, such as the air temperature and the moisture fields. Therefore, the application of a drier or wetter soil in distinct soil layers within the whole vertical soil profile has been found to be crucial in order to produce a better agreement between the simulation and the observations, thus reiterating the determining role of the initial soil moisture field in mesoscale modelling, but in this case considering the variation of this parameter vertically. [ABSTRACT FROM AUTHOR]

Extreme heat weather events have received increasing attention and has become of special importance as they can remarkably affect sectors as diverse as public health, energy consumption, water resources, natural biodiversity and agricultural production. In this regard, summer temperatures have become a parameter of essential interest under a framework of a hypothetical increase in the number of intense-heat conditions. Thus, their forecast is a crucial aspect bearing in mind a mitigation of the effects and impacts that these intense-heat situations could produce. The current work tries to reach a better understanding of these sorts of situations that are really common over theWestern Mediterranean coast. An extreme heat episode that took place in the Valencia Region in July 2009 is analysed, based on the simulations performed with the Regional Atmospheric Modeling System (RAMS). This event recorded maximum temperatures exceeding 40 °C amply extended over the region besides reaching minimum temperatures up to 25.92 °C. We examine the role of improved skin and soil temperature (ST) initial conditions in the forecast results by means of different modelling and satellite-derived products. The influence of incorporating the Land Surface Temperature (LST) into RAMS is not found to produce a meaningful impact on the simulation results, independently of the resolution of the dataset used in the initial conditions of the model. In contrast, the introduction of the ST in lower levels, not only the skin temperature, has a more marked decisive effect in the simulation. Additionally, we have evaluated the influence of increasing the number of soil levels to spread deeper underground. This sensitivity experiment has revealed that more soil levels do not produce any meaningful impact on the simulation compared to the original one. In any case, RAMS is able to properly capture the observed patterns in those cases where a Western advection is widely extended over the area of study. This region's variability in orography and in distances to the sea promotes the development of sea-breeze circulations, thus producing a convergence of two opposite wind flows, a Western synoptic advection and a sea-breeze circulation. As a result, the RAMS skill in those cases where a sea breeze is well developed depends on the proper location of the boundary and convergence lines of these two flows. [ABSTRACT FROM AUTHOR]

Solar radiation is a key factor in the Earth's energy balance and it is used as a crucial input parameter in many disciplines such as ecology, agriculture, solar energy and hydrology. Thus, accurate information of the global downward surface shortwave flux integration into the grid is of significant importance. From the different strategies used for grid integration of the surface solar radiation estimates, satellite-derived and numerical weather prediction forecasts are two interesting alternatives. In the current work, we present a comprehensive evaluation of the global downward solar radiation forecasts provided by the Regional Atmospheric Modeling System (RAMS) and the Downwelling Surface Shortwave Flux (DSSF) product, derived from the Meteosat Second Generation (MSG) Spinning Enhanced Visible and Infrared Imager (SEVIRI). Both solar radiation estimates are compared to thirteen ground-based weather station measurements for the winter 2010-2011 and the summer 2011 seasons. For these periods, the most recent versions of RAMS (4.4 and 6.0) were running in parallel within the real-time weather forecasting system implemented over the Valencia Region. The solar radiation performance and accuracy are evaluated for these datasets segmented into two atmospheric conditions (clear and cloudy skies) and two terrain classes (flat and hilly). DSSF shows a very good agreement over the study area. Statistical daily evaluations show that corresponding errors vary between seasons, with absolute bias ranging from -30 to 40 W⋅m-2, absolute root mean square errors (RMSE) from 25 to 60 W⋅m-2, relative bias ranging from -11% to 7% and relative RMSE from 7% to 22%, depending on the sky condition and the terrain location as well, thus reproducing the observations more faithfully than RAMS, which produces higher errors in comparison to the measurements. In this regard, statistical daily evaluations show absolute bias values varying from -50 to 160 W⋅m-2, absolute RMSE from 60 to 240 W⋅m-2, relative bias ranging from -30% to 40% and relative RMSE from 10% to 80%, also depending on the daily initialization and the forecast horizon. This bias variability demonstrates that there is a different trend in the deviation of the model results in relation to the observations, both for the DSSF product and RAMS forecasts, and considering the summer and the winter seasons independently. In this regard, although there is an overestimation of the observed solar radiation within the summer months, this magnitude is underestimated during the winter. Finally, comparing this solar radiation estimates for different atmospheric conditions and different terrain classes, the best results are found under clear skies over flat terrain. This result is achieved using both methodologies. [ABSTRACT FROM AUTHOR]

The current study evaluates the ability of the Weather Research and Forecasting Model (WRF) to forecast surface energy fluxes over a region in Eastern Spain. Focusing on the sensitivity of the model to Land Surface Model (LSM) parameterizations, we compare the simulations provided by the original Noah LSM and the Noah LSM with multiple physics options (Noah-MP). Furthermore, we assess the WRF sensitivity to different Noah-MP physics schemes, namely the calculation of canopy stomatal resistance (OPT_CRS), the soil moisture factor for stomatal resistance (OPT_BTR), and the surface layer drag coefficient (OPT_SFC). It has been found that these physics options strongly affect the energy partitioning at the land surface in short-time scale simulations. Aside from in situ observations, we use the Meteosat Second Generation (MSG) Spinning Enhanced Visible and Infrared Imager (SEVIRI) sensor to assess the Land Surface Temperature (LST) field simulated by WRF. Regarding multiple options in Noah-MP, WRF has been configured using three distinct soil moisture factors to control stomatal resistance (β factor) available in Noah-MP (Noah, CLM, and SSiB-types), two canopy stomatal resistance (Ball–Berry and Jarvis), and two options for surface layer drag coefficients (Monin–Obukhov and Chen97 scheme). Considering the β factor schemes, CLM and SSiB-type β factors simulate very low values of the latent heat flux while increasing the sensible heat flux. This result has been obtained independently of the canopy stomatal resistance scheme used. Additionally, the surface skin temperature simulated by Noah-MP is colder than that obtained by the original Noah LSM. This result is also highlighted when the simulated surface skin temperature is compared to the MSG-SEVIRI LST product. The largest differences between the satellite data and the mesoscale simulations are produced using the Noah-MP configurations run with the Monin–Obukhov parameterization for surface layer drag coefficients. In contrast, the Chen97 scheme shows larger surface skin temperatures than Monin–Obukhov, but at the expense of a decrease in the simulated sensible heat fluxes. In this regard, the ground heat flux and the net radiation play a key role in the simulation results. [ABSTRACT FROM AUTHOR]

Hereditary Fructose Intolerance (HFI) is an autosomal recessive inborn error of metabolism characterised by the deficiency of the hepatic enzyme aldolase B. Its treatment consists in adopting a fructose-, sucrose-, and sorbitol (FSS)-restrictive diet for life. Untreated HFI patients present an abnormal transferrin (Tf) glycosylation pattern due to the inhibition of mannose-6-phosphate isomerase by fructose-1-phosphate. Hence, elevated serum carbohydrate-deficient Tf (CDT) may allow the prompt detection of HFI. The CDT values improve when an FSS-restrictive diet is followed; however, previous data on CDT and fructose intake correlation are inconsistent. Therefore, we examined the complete serum sialoTf profile and correlated it with FSS dietary intake and with hepatic parameters in a cohort of paediatric and adult fructosemic patients. To do so, the profiles of serum sialoTf from genetically diagnosed HFI patients on an FSS-restricted diet (n = 37) and their age-, sex- and body mass index-paired controls (n = 32) were analysed by capillary zone electrophoresis. We found that in HFI patients, asialoTf correlated with dietary intake of sucrose (R = 0.575, p < 0.001) and FSS (R = 0.475, p = 0.008), and that pentasialoTf+hexasialoTf negatively correlated with dietary intake of fructose (R = −0.386, p = 0.024) and FSS (R = −0.400, p = 0.019). In addition, the tetrasialoTf/disialoTf ratio truthfully differentiated treated HFI patients from healthy controls, with an area under the ROC curve (AUROC) of 0.97, 92% sensitivity, 94% specificity and 93% accuracy. [ABSTRACT FROM AUTHOR]

Infective endocarditis is a rather uncommon disease, but it has significant mortality rates in the pediatric population (5% to 10%). We report a case of an infant patient with multiple vegetation in the tricuspid valve secondary to infective endocarditis caused by Corynebacterium diphtheriae. A tricuspid valvuloplasty was performed with a fenestrated autologous pericardium patch, providing satisfactory outcomes. This technique is simple, innovative, effective, and it could be applied in similar cases.