Search

Your search keyword '"Gelovani, Juri"' showing total 468 results
Start Over Author "Gelovani, Juri" Publication Type Academic Journals
468 results on '"Gelovani, Juri"'

2. Next-generation of targeted AAVP vectors for systemic transgene delivery against cancer

Author

Suwan, Keittisak, Yata, Teerapong, Waramit, Sajee, Przystal, Justyna M, Stoneham, Charlotte A, Bentayebi, Kaoutar, Asavarut, Paladd, Chongchai, Aitthiphon, Pothachareon, Peraphan, Lee, Koon-Yang, Topanurak, Supachai, Smith, Tracey L, Gelovani, Juri G, Sidman, Richard L, Pasqualini, Renata, Arap, Wadih, and Hajitou, Amin

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Gene Therapy, Nanotechnology, Rare Diseases, Biotechnology, Cancer, Genetics, Bioengineering, 5.2 Cellular and gene therapies, Development of treatments and therapeutic interventions, Animals, Antibodies, Neutralizing, Antibodies, Viral, Bacteriophage M13, Capsid Proteins, Cell Line, Tumor, Dependovirus, Endosomes, Genetic Therapy, Genetic Vectors, Humans, Lysosomes, Mice, Neoplasms, Oligopeptides, Proof of Concept Study, Rats, Transduction, Genetic, Virus Internalization, Xenograft Model Antitumor Assays, AAVP, cancer, gene delivery, phage display, preclinical studies
Abstract

Bacteriophage (phage) have attractive advantages as delivery systems compared with mammalian viruses, but have been considered poor vectors because they lack evolved strategies to confront and overcome mammalian cell barriers to infective agents. We reasoned that improved efficacy of delivery might be achieved through structural modification of the viral capsid to avoid pre- and postinternalization barriers to mammalian cell transduction. We generated multifunctional hybrid adeno-associated virus/phage (AAVP) particles to enable simultaneous display of targeting ligands on the phage's minor pIII proteins and also degradation-resistance motifs on the very numerous pVIII coat proteins. This genetic strategy of directed evolution bestows a next-generation of AAVP particles that feature resistance to fibrinogen adsorption or neutralizing antibodies and ability to escape endolysosomal degradation. This results in superior gene transfer efficacy in vitro and also in preclinical mouse models of rodent and human solid tumors. Thus, the unique functions of our next-generation AAVP particles enable improved targeted gene delivery to tumor cells.

Published
2019

5. Rapid lung ventilation MRI using parahydrogen-induced polarization of propane gas.

Author

Chowdhury, Md Raduanul H., Oladun, Clementinah, Ariyasingha, Nuwandi M., Samoilenko, Anna, Bawardi, Tarek, Burueva, Dudari B., Salnikov, Oleg G., Kovtunova, Larisa M., Bukhtiyarov, Valerii I., Shi, Zhongjie, Luo, Kehuan, Tan, Sidhartha, Gelovani, Juri G., Koptyug, Igor V., Goodson, Boyd M., and Chekmenev, Eduard Y.

Subjects
CONTRAST media, VENTILATION, PROTONS, PROPANE, SCANNING systems, PROPANE as fuel, LUNGS
Abstract

Proton-hyperpolarized contrast agents are attractive because they can be imaged on virtually any clinical MRI scanner, which is typically equipped to scan only protons rather than heteronuclei (i.e., anything besides protons, e.g., 13C, 15N, 129Xe, 23Na, etc.). Even though the lifetime of the proton spin hyperpolarization is only a few seconds, it is sufficient for inhalation and scanning of proton-hyperpolarized gas media. We demonstrate the utility of producing hyperpolarized propane gas via heterogeneous parahydrogen-induced polarization for the purpose of ventilation imaging in an excised rabbit lung model. The magnetization of protons in hyperpolarized propane gas is similar to that of tissue water protons, making it possible to rapidly perform lung ventilation imaging with a 0.35 T clinical MRI scanner. Here, we demonstrate the feasibility of rapid (2 s) lung ventilation MRI in excised rabbit lungs using hyperpolarized propane gas with a 1 × 1 mm2 pixel size using a 50 mm slice thickness, and a 1.7 × 1.7 mm2 pixel size using a 9 mm slice thickness. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. CD8+ T cells inhibit metastasis and CXCL4 regulates its function

Author

Joseph, Robiya, Soundararajan, Rama, Vasaikar, Suhas, Yang, Fei, Allton, Kendra L., Tian, Lin, den Hollander, Petra, Isgandarova, Sevinj, Haemmerle, Monika, Mino, Barbara, Zhou, Tieling, Shin, Crystal, Martinez-Paniagua, Melisa, Sahin, Aysegul A., Rodriguez-Canales, Jaime, Gelovani, Juri, Chang, Jeffrey T., Acharya, Ghanashyam, Sood, Anil K., Wistuba, Ignacio I., Gibbons, Don L., Solis, Luisa M., Barton, Michelle C., Varadarajan, Navin, Rosen, Jeffrey M., Zhang, Xiang H., and Mani, Sendurai A.

Published
2021
Full Text
View/download PDF

9. The Structures, Functions, and Roles of Class III HDACs (Sirtuins) in Neuropsychiatric Diseases.

Author

Bonomi, Robin E., Riordan, William, and Gelovani, Juri G.

Subjects
SIRTUINS, CELL communication, MENTAL illness, AFFECTIVE disorders, DEACETYLASES
Abstract

Over the past two decades, epigenetic regulation has become a rapidly growing and influential field in biology and medicine. One key mechanism involves the acetylation and deacetylation of lysine residues on histone core proteins and other critical proteins that regulate gene expression and cellular signaling. Although histone deacetylases (HDACs) have received significant attention, the roles of individual HDAC isoforms in the pathogenesis of psychiatric diseases still require further research. This is particularly true with regard to the sirtuins, class III HDACs. Sirtuins have unique functional activity and significant roles in normal neurophysiology, as well as in the mechanisms of addiction, mood disorders, and other neuropsychiatric abnormalities. This review aims to elucidate the differences in catalytic structure and function of the seven sirtuins as they relate to psychiatry. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques

Author

Brammer, David W., Gillespie, Patrick J., Tian, Mei, Young, Daniel, Raveendran, Muthuswamy, Williams, Lawrence E., Gagea, Mihai, Benavides, Fernando J., Perez, Carlos J., Broaddus, Russell R., Bernacky, Bruce J., Barnhart, Kirstin F., Alauddin, Mian M., Bhutani, Manoop S., Gibbs, Richard A., Sidman, Richard L., Pasqualini, Renata, Arap, Wadih, Rogers, Jeffrey, Abee, Christian R., and Gelovani, Juri G.

Published
2018

18. Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes

Author

Dobroff, Andrey S., D’Angelo, Sara, Eckhardt, Bedrich L., Ferrara, Fortunato, Staquicini, Daniela I., Cardó-Vila, Marina, Staquicini, Fernanda I., Nunes, Diana N., Kim, Kisu, Driessen, Wouter H. P., Hajitou, Amin, Lomo, Lesley C., Barry, Marc, Krishnamurthy, Savitri, Sahin, Aysegul, Woodward, Wendy A., Prossnitz, Eric R., Anderson, Robin L., Dias-Neto, Emmanuel, Brown-Glaberman, Ursa A., Royce, Melanie E., Ueno, Naoto T., Cristofanilli, Massimo, Hortobagyi, Gabriel N., Marchiò, Serena, Gelovani, Juri G., Sidman, Richard L., Arap, Wadih, and Pasqualini, Renata

Published
2016

19. Targeted molecular-genetic imaging and ligand-directed therapy in aggressive variant prostate cancer

Author

Ferrara, Fortunato, Staquicini, Daniela I., Driessen, Wouter H. P., D’Angelo, Sara, Dobroff, Andrey S., Barry, Marc, Lomo, Lesley C., Staquicini, Fernanda I., Cardó-Vila, Marina, Soghomonyan, Suren, Alauddin, Mian M., Flores, Leo G., Arap, Marco A., Lauer, Richard C., Mathew, Paul, Efstathiou, Eleni, Aparicio, Ana M., Troncoso, Patricia, Navone, Nora M., Logothetis, Christopher J., Marchiò, Serena, Gelovani, Juri G., Sidman, Richard L., Pasqualini, Renata, and Arap, Wadih

Published
2016

26. Candidate biomarkers of pathologic brain aging

Author

Kuznetsov, Nikolay, Morozova, Daria, Liaonchyk, Katsiaryna, Kashapov, Aidar, Meribout, Sarah, Smetanina, Darya, Simiyu, Gillian, Ismail, Fatima, Gorkom, Klaus, Gelovani, Juri, Ljubisavljevic, Milos, and Statsenko, Yauhen

Published
2023
Full Text
View/download PDF

41. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

Author

Hosoya, Hitomi, Dobroff, Andrey S., Driessen, Wouter H. P., Cristini, Vittorio, Brinker, Lina M., Staquicini, Fernanda I., Cardó-Vila, Marina, D’Angelo, Sara, Ferrara, Fortunato, Proneth, Bettina, Lin, Yu-Shen, Dunphy, Darren R., Dogra, Prashant, Melancon, Marites P., Stafford, R. Jason, Miyazono, Kohei, Gelovani, Juri G., Kataoka, Kazunori, Brinker, C. Jeffrey, Sidman, Richard L., Arap, Wadih, and Pasqualini, Renata

Published
2016

45. Radiopharmaceuticals for Positron Emission Tomography Imaging of Amyloid: Research and Clinical Applications in Thailand.

Author

Siriprapa, Tossaporn, Thientunyakit, Tanyaluck, and Gelovani, Juri

Subjects
AMYLOID, RADIOPHARMACEUTICALS, POSITRON emission tomography, ALZHEIMER'S disease diagnosis, DEMENTIA
Abstract

In the past two decades, the research community has focused on defining reliable molecular biomarkers for the early diagnosis of Alzheimer's disease (AD). Several positron emission tomography (PET) radiopharmaceuticals have been developed and gained regulatory approval for the non-invasive detection of amyloid-ß (Aß) amyloid deposits in the brain. Nowadays, there are several PET imaging radiopharmaceuticals available in Thailand for amyloid imaging including [11C]-labeled Pittsburgh compound B ([11C]PiB), [18F]Florbetapir, and [18F]Florbetaben. This review provides a summary of commonly used amyloid PET radiopharmaceuticals, focusing on the available radiopharmaceuticals in Thailand and the experiences of using amyloid PET radiopharmaceuticals and imaging for clinical and research applications at Siriraj Hospital. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

49. Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with 18F-FAHA

Author

Yeh, Hsin-Hsien, Tian, Mei, Hinz, Rainer, Young, Daniel, Shavrin, Alexander, Mukhapadhyay, Uday, Flores, Leo G., Balatoni, Julius, Soghomonyan, Suren, Jeong, Hwan J., Pal, Ashutosh, Uthamanthil, Rajesh, Jackson, James N., Nishii, Ryuichi, Mizuma, Hiroshi, Onoe, Hirotaka, Kagawa, Shinya, Higashi, Tatsuya, Fukumitsu, Nobuyoshi, Alauddin, Mian, Tong, William, Herholz, Karl, and Gelovani, Juri G.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results