Search

Your search keyword '"Gastrointestinal Lipase Inhibitor"' showing total 1 results
Start Over Descriptor "Gastrointestinal Lipase Inhibitor" Publication Type Academic Journals
1 results on '"Gastrointestinal Lipase Inhibitor"'

1. With Asymmetric Hydrogenation Towards a New, Enantioselective Synthesis of Orlistat

Author

Rolf Birk, Martin Karpf, Kurt Püntener, Michelangelo Scalone, Mark Schwindt, and Ulrich Zutter

Subjects
Asymmetric hydrogenation, Gastrointestinal lipase inhibitor, Beta-ketoester, Process research, Chemistry, QD1-999
Abstract

A new, enantioselective synthesis of Orlistat suitable for large-scale production is described, wherein the first enantiomerically pure intermediate methyl (R)-3-hydroxy-tetradecanoate is prepared via asymmetric hydrogenation of methyl 3-oxotetradecanoate. The relevant criteria associated with the application of the asymmetric hydrogenation technology are addressed, such as the activity, the selectivity and the availability of the catalyst as well as the quality of the hydrogenation substrate and the hydrogen gas.

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results