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Natanim Degefu,1 Abera Jambo,2 Shambel Nigusse,2 Mesay Dechasa,2 Tigist Gashaw,3 Melaku Getachew4 1Department of Pharmaceutics, School of Pharmacy, Haramaya University, Harar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, Haramaya University, Harar, Ethiopia; 3Department of Pharmacology, School of Pharmacy, Haramaya University, Harar, Ethiopia; 4Department of Emergency and Critical Care Medicine, School of Medicine, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Melaku Getachew, Department of Emergency and critical care medicine, School of Medicine, College of Health and Medical Sciences, Haramaya University, P.O. Box: 138, Harar, Ethiopia, Tel +251953137119, Email melakug02@gmail.comBackground: Despite cardiogenic pulmonary edema is the most common phenotype of acute heart failure (AHF), studies on its burden and associated factors are limited. This study aimed to assess the burden and contributing factors of cardiogenic pulmonary edema in patients with acute heart failure admitted to a tertiary hospital in eastern Ethiopia.Patients and Methods: An institution-based cross-sectional study was conducted on the medical records (n = 276) of patients with AHF between February 01, 2018, and January 31, 2023. A simple random sampling technique was used to select participants from the study population. Bivariable and multivariable logistic regression analyses were used to assess factors associated with the development of cardiogenic pulmonary edema. A P-value ≤ 0.05 was considered as statistically significant.Results: The prevalence of cardiogenic pulmonary edema was 47.8% in AHF patients. Rural residence (adjusted odds ratio (AOR),9.54), smoking (AOR,3.17), comorbidity (AOR,2.1), and underlying cardiovascular disease (ischemic heart disease, chronic rheumatic valvular heart disease, and hypertensive heart disease with AOR: 6.71, 8.47, and 12.07, respectively) were significantly associated with the development of cardiogenic pulmonary edema in patients with AHF.Conclusion: Nearly half of the patients with AHF had cardiogenic pulmonary edema. Being a rural dweller, cigarette smoking, comorbidities, and underlying cardiac illness were significantly associated with the development of cardiogenic pulmonary edema in patients with AHF.Keywords: acute heart failure, cardiogenic pulmonary edema, Ethiopia, tertiary hospital

Aklilu Tekeba,1 Yohanes Ayele,2 Belay Negash,3 Tigist Gashaw4 1Micheta Community Pharmacy, Daro Lebu Health Office, West Harerghe, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Hawassa University, Hawassa, Ethiopia; 3School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Tigist GashawDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, PO Box 235, Harar, EthiopiaTel +251-91-202-7244Fax +256668081Email yekalabel@gmail.comBackground: Self-medication is one aspect of self-care that has been shown to benefit primary health care. When done correctly, it provides significant benefits to customers, such as self-reliance and cost savings. Inappropriate methods, on the other hand, such as incorrect self-diagnosis and therapy selection, can be disastrous. The COVID-19 pandemic context may benefit the community in easing the burden on the health system. There have been no studies conducted on this possibility in the context of COVID-19 in a selected area, hence the purpose of this study was to determine the extent of and factors associated with self-medication among clients visiting community pharmacies in west Harerghe, Ethiopia from June 1 to 30, 2020.Methods: This institution-based cross-sectional study used a systemic random sample of 416 community-pharmacy clients. To collect data, face-to-face interviews were conducted using pretested semistructured questionnaires modified from established techniques. EpiData 3.1 was used to enter data and SPSS 24 for analysis. To determine factors associated with self-medications, bivariate and multivariate logistic regression analyses were performed. AORs with 95% CIs are used to report associations, and the level of significance was set at P< 0.05.Results: The proportion of people self-medicating was 73.6% (95% CI 69.2%– 77.9%). Self-medications were significantly associated with age 18– 24 years (AOR 9.28, 95% CI 3.56– 24.21) and 25– 34 years (AOR 3.54, 95% CI 1.35– 9.27), Amhara ethnicity (AOR 1.72, 95% CI 1.01– 2.94), current single status (AOR 0.28, 95% CI 0.15– 0.51), government employment (AOR 0.31, 95% CI 0.12– 0.82), and limited knowledge (AOR 2.31, 95% CI 1.40– 3.79).Conclusion: Three in four participants practiced self-medication in the era of COVID-19. Repetition was significantly associated with age, ethnicity, current marital status, type of occupation, and knowledge about self-medications. An alternative medical care–delivery system by all health-care providers and increasing community awareness should be promoted.Keywords: self-medication, community pharmacy, COVID-19, Ethiopia

Mekonnen Sisay,1 Tigist Gashaw,1 Natanim Degefu,2 Bisrat Hagos,3 Addisu Alemu,4 Zenebu Teshome,5 Mekonnen Admas,6 Haregeweyn Kibret,7 Yadeta Dessie4 1Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Pharmaceutics, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 3Department of Social Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4Department of Public Health and Health Policy, School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 5East Harerge Zone Administration Office, Harar, Ethiopia; 6HIV/AIDS Unit, Gender, HIV/AIDS and Special Need Affair Directorate, Haramaya University, Harar, Ethiopia; 7Department of Nursing, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Mekonnen SisayDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, P.O. Box, 235, Harar, EthiopiaEmail mekonnensisay27@yahoo.comBackground: The COVID-19 crisis has already resulted in an economic and labor market shock and a rise of informal work sectors. Being an informal job, traditional coffee vending can predispose women to a myriad of mental disorders. Therefore, this study was aimed to assess depressive symptoms during the COVID-19 pandemic and associated factors among street traditional coffee vendors in Harar town, Eastern Ethiopia.Methods: A cross-sectional study was employed on 180 women engaged in street traditional coffee vending business in Harar town. Data were collected through a face-to-face interview using a Public Health Questionnaire and analyzed using SPSS version 20. Binary logistic regression was executed to identify factors associated with depression at a cut-off point of P < 0.05.Results: The mean age of the study participants was 31.83 (± 10) years. The majority of the participants were currently married (n = 77, 42.8%), attended primary education (n = 68, 37.8%), had a family member of four or more (n = 60, 33.3%), and had two years or less work experience (n = 123, 68.3%). Most of the study participants obtained COVID-19-related information from television (n = 125, 69.4%). The prevalence of depression was found to be 18.9%. Attending primary education (AOR: 0.34; 95% CI: 0.12, 0.98), attending secondary education or higher (AOR: 0.23; 95% CI: 0.07, 0.69), and having four or more family members (AOR: 2.81; 95% CI: 1.14, 6.92) were significantly associated with depression.Conclusion: One in five street traditional coffee vendors suffered from depression during the COVID-19 pandemic. Lower odds of being depressed were observed in those who attended a minimum of primary education. On the contrary, having a greater family size was associated with higher odds of being depressed. This finding will direct the government and other concerned bodies to be involved in the provision of psychological and material support for such informal workers during COVID-19.Keywords: coronavirus, depression, street, traditional coffee vending

Tigist Gashaw,1 Mekonnen Sisay,1 Tewodros Tesfa,2 Yohannes Baye,3 Firehiwot Amare4 1Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Microbiology Unit, Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 3Department of Pediatrics and Neonatal Nursing, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Tigist GashawDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, P.O. Box 235, Harar, EthiopiaEmail yekalabel@gmail.comIntroduction: Penicillin is among the highly used antibiotics in most parts of the world, with amoxicillin being the most frequently utilized drug in the category. However, amoxicillin use has been found to deviate from standard treatment guidelines (STGs).Objective: This study aimed to evaluate amoxicillin utilization patterns based on Ethiopian STGs criteria at four governmental hospitals in Harar town: Hiwot Fana Specialized University Hospital, Jugel Hospital, South East Command III Hospital, and Federal Harar Police Hospital in Eastern Ethiopia in 2016.Methods: A hospital-based retrospective cross-sectional study was employed using medication records of patients who received amoxicillin in 2016 at four governmental hospitals from May 15 to June 30, 2018. A total of 502 medication records were proportionally allocated based on the ratio of consumption data of each hospital. Simple random sampling was employed to collect the required sample from the sampling frame. The collected data were entered into SPSS version 21 and analyzed using descriptive analysis.Results: Amoxicillin was used in all age groups, including pregnant and lactating women. The majority (96.2%) of patients were from the outpatient departments. Complete blood count was the most laboratory investigation carried out in 24.9% whereas microbiological culture was not recorded at all. Top three indications include nonspecific upper respiratory tract infections (15.1%), pneumonia (13.5%) and dental problems (10.6%). Non-steroidal anti-inflammatory drugs (56.2%) were frequently co-administered agents. An appropriate utilization was made considering indication, dose, frequency and therapy duration in 23.9% as per the Ethiopian STG. The wrong indication (65.4%) was the prime reason for inappropriateness, followed by dose (14.6%) and duration of therapy (12.2%).Conclusion: Amoxicillin utilization was appropriate in less than a quarter of patients. The wrong indication was the main reason for inappropriateness, predisposing to resistance development. Further studies identifying factors related to misuse and sensitivity tests should be the next steps.Keywords: amoxicillin, utilization, antibiotics, resistance, appropriateness

Mekonnen Sisay,1 Tigist Gashaw,1 Firehiwot Amare,2 Tewodros Tesfa,3 Yohannes Baye4 1Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 3Microbiology Unit, Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 4Department of Pediatrics and Neonatal Nursing, School of Nursing and Midwifery, College of Health and Medical Sciences, Haramaya University, Harar, EthiopiaCorrespondence: Mekonnen SisayDepartment of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, P.O. Box, 235, Harar, EthiopiaTel +251 920 21 21 35Fax +251 256 66 80 81Email mekonnensisay27@yahoo.comBackground: Antibacterial agents are an integral part of chemotherapy and play a critical role in the prophylaxis and treatment of bacterial infections. However, prescribing errors such as incomplete prescriptions that do not adhere to good prescribing practice have become a contemporary concern in hospitals in resource-limited settings. Therefore, this study aimed to assess antibacterial prescribing and its completeness among prescriptions dispensed at four governmental hospitals in Eastern Ethiopia.Methods: A cross-sectional study was employed to assess a total of 1308 prescription encounters containing at least one antibacterial agent obtained with simple random sampling from annual antibacterial-containing prescription data of four hospitals. The data were collected retrospectively using a structured checklist.Results: A total of 2,855 drugs were prescribed from 1308 prescribing encounters with 1496 (52.39%) being antibacterial agents. The name, age, sex, and diagnosis of the patients were written in 1158 (88.3%), 815 (62.31%), 796 (60.58%), and 183 (13.99%) prescriptions, respectively. Besides, the route of administration, strength, duration, quantity, dose, and dosage form of the drug were recorded in 2322 (81.33%), 2118 (74.19%), 1516 (53.10%), 1525 (53.42%), 746 (26.13%) and 563 (19.72%) prescriptions, respectively. Nearly 50% of the prescribing encounters were documented without a prescriber name. Dispenser name and signature were also obtained in less than 10% of the prescriptions. Combining the data of all hospitals, amoxicillin, ceftriaxone, and ciprofloxacin were identified as the top three prescribed antibacterial drugs, whereas diclofenac, paracetamol, and tramadol were the most frequently co-indicated drugs. Regarding the pharmacologic class of antibiotics, penicillins were the most commonly prescribed antibiotics (n = 596, 39.77%) followed by cephalosporins (n = 318, 21.26%) and fluoroquinolones (n=285, 19.05%).Conclusion: Incomplete information about patient-related factors and major diagnosis, medication regimens, prescribers and dispensers was identified as a potential prescribing error and did not adhere to good prescribing practice. This can be considered as one part of the inappropriate use of antibacterial agents, a driving force for the emergence of antimicrobial resistance. This problem requires immediate and sustained action from the management of the hospitals to ensure the accountability of health professionals involved in the medication use process and to establish antimicrobial stewardship programs in such resource-limited settings.Keywords: prescribing practice, completeness, antibacterial drugs, Eastern Ethiopia

Poor diet quality has been identified as a primary driver of malnutrition and increasing burden of noncommunicable diseases in low- and middle-income countries. Low fruit and vegetable consumption contributes to poor diet quality. We experimentally assess whether videos embedded messages about increasing fruit and vegetable consumption affect consumption. Four months after viewing either a basic video or a video that explains why fruits and vegetables can improve health and nutrition outcomes, average household consumption of fruits and vegetables increased by about 9% in both treatment groups relative to the control group, both in kilocalorie and consumption expenditure terms. [ABSTRACT FROM AUTHOR]

The surface urban heat island (SUHI) is caused by a combination of variables, broadly classified as climate change, land use change, and urbanization. They have varying degrees of influence depending on their level of intensity. As a result, recognizing the primary cause is critical to resolving the issue and developing suitable policies to reduce resource waste. This study attempted to identify the underlying cause of SUHI by primarily evaluating the intensity of the surface urban heat island using primary and secondary data. Zonal Statistics, the Mann-Kendall trend test, Oke’s UHI model, multiple linear regression, and Likert Scale were used in the analysis. The average SUHII value, Beta coefficient, and mean value of the Likert scale for urbanization are the highest, followed by Land use and climate change. The average temperature induced by population density is 3.85 °C and its Beta value is 0.449 which is significant at p

Telescoping errors occur if survey respondents misdate events from outside the reference period and include them in their recall. Concern about telescoping influenced the design of early Living Standards Measurement Study (LSMS) surveys, which used a two-visit interview format to bound food consumption recall. This design fell out of favor although not for evidence-based reasons. To measure the extent of telescoping bias on food consumption measures, a survey experiment was conducted in Addis Ababa, Ethiopia, randomly assigning households to either a two-visit bounded recall or a single visit unbounded recall. The average value of reported food consumption is 16 percent higher (95 percent CI: 7.4–25.9) in the unbounded single visit recall relative to the two-visit bounded recall. Most of the error is explained by difference in reported spending on less frequently consumed, protein-rich foods, so apparent food security indicators based on household diet diversity are likely overstated with unbounded recall. [ABSTRACT FROM AUTHOR]

Abstract Background The first twelve months after a woman has given birth is crucial for the use of contraceptives to prevent unintended pregnancy. Most women, especially in developing countries, do not realize that they are at risk for pregnancy during this period. Due to this, contraceptive use by women is ignored at this time. Objective This study assessed the associated factors of postpartum family planning (PPFP) service uptake in the Asosa zone. Methods A facility-based cross-sectional study was conducted among 396 postpartum women in the Asosa zone. An interviewer-administered, structured, and pre-tested questionnaire was used to collect data. Data entry and cleaning were done using Epi Info version 7.0 and analyzed using SPSS version 25 software. Multivariate logistic regression analysis was employed to identify factors associated with postpartum family planning uptake. Results The majority of the study participants, 384 (97.2%), had heard about at least one method of family planning. Nearly two-thirds of the study participants (64.1%) had resumed sexual intercourse. Only 53.5% of the participants started using PPFP. Injectable forms (54.7%) and implants (26.4%) were the most commonly used methods. More than one-fourth (27.4%) did not use their preferred methods. Family planning use before index pregnancy (AOR = 4.8, 95% CI: 2.65, 8.82), previous use of PPFP (AOR = 2.4, 95% CI: 1.33, 4.38)] and health facility delivery (AOR = 2.8, 95% CI: 1.46, 5.49)] were significantly associated with uptake of postpartum family planning. Conclusion and recommendation : Postpartum family planning uptake in the study area was low. Uptake of PPFP was correlated with prior family planning usage and delivery at a healthcare facility. Given these factors, we recommend all study area stakeholders to promote family planning use among women of reproductive age and to encourage deliveries at healthcare facilities. Designing a method to reach women who give birth at home for a variety of reasons is also advisable. Unavailability of different forms of FP also made the participants not use the preferred option. Therefore, we recommend the stakeholders in the study area to avail variety of FP methods.

Increased deployment of agricultural extension agents (EAs) in rural areas is recommended to spur agricultural productivity and mitigate spatial imbalances in welfare. However, high turnover and low motivation levels of EAs in remote areas pose challenges for equitable service provision and, in some cases, exacerbate geographical welfare disparities. We assess the effectiveness of selected potential policy interventions to incentivise and retain EAs in remote areas of Ethiopia. To this end, we conducted a choice experiment to elicit the preferences of 761 EAs for job attributes. We apply a random parameters logit model to estimate parameters of interest and to simulate the impact of possible policy interventions. Our results show that offering education opportunities is by far the most powerful instrument to attract and retain EAs. It increases uptake of the extension job in remote locations by 77 percentage points, which is significantly higher than the effect from doubling current salary levels. EAs also expressed a strong preference for work environments with basic amenities, housing, transportation services, and well‐equipped Farmer Training Centres (FTCs). Furthermore, the results from sub‐sample analyses show that female EAs are less responsive to pecuniary incentives and are more concerned with the availability of infrastructure and amenities. Current salary levels, years of employment, and location of work are also important sources of heterogeneity in the response of EAs to potential policy changes. [ABSTRACT FROM AUTHOR]

International humanitarian organizations have expressed substantial concern about the potential for increases in food insecurity resulting from the COVID‐19 pandemic. We use a unique panel survey of a representative sample households in Addis Ababa to study both food security and food consumption during the pandemic. In contrast to some other countries in the region, Ethiopia never went into a full lockdown severely restricting movement. Despite subjective income measures suggesting a large proportion of households have been exposed to job loss or reduced incomes, we find that relative to a survey conducted in August and September of 2019, food consumption and household dietary diversity are largely unchanged or slightly increased by August 2020. We find some changes in the composition of food consumption, but they are not related to shocks found in previous phone surveys conducted with the same households. The results therefore suggest the types of subjective questions about income typically being asked in COVID‐19 phone surveys may not appropriately reflect the magnitude of such shocks. They also imply, at least indirectly, that in the aggregate food value chains have been resilient to the shock associated with the pandemic. [ABSTRACT FROM AUTHOR]

The study was conducted to investigate the breeding season, sex ratio, size at maturation, fecundity and condition factor of African catfish Clarias gariepinus in Lake Koka. A total of 754 fish specimens were collected from October 2020 to August 2021. Total length and weight were measured and sexes were identified and gonad maturity levels were recorded. The sex ratio of African catfish in different size classes was similar to that of a hypothetical 1:1 ratio. The length at first maturity (L50) was 51.8 cm in total length. The mean Fulton’s condition factor of female African catfish ranged from 0.65 ± 0.05 – 0.71 ± 0.14, while the males ranged from 0.62 ± 0.04 – 0.7 ± 0.11. The Fulton’s condition factor was significantly higher in August for females than in the rest of the sampling months. The highest ripe gonads were recorded in the rainy season and the lowest was in the dry season, with the percentage of ripe gonads being 27.5%, while the males showed similarly extended maturity patterns among seasons. Fisheries management for African catfish should therefore take into account the estimated L50 value and the main breeding season to sustain the fishery and benefits the fishermen.

The Afar region is characterized by an arid and semi-arid climate with erratic rainfall and is prone to frequent droughts despite being endowed with fresh and saline water bodies along the Awash River Basin. Lake Hertale is one of those fresh water bodies located in the middle of the Awash River Valley. The lake's fishery is presumed not to have been exploited before. The study attempted to describe some physico-chemical parameters, fish species composition, estimate production potential which are relevant to develop a lake fishery with the prospect of contributing to food and nutrition security. The nutrient and chlorphyl-a measurements indicated eutrophic state but with apparently comparative low primary biomass. Conductivity, dissolved oxygen and temperature were within the optimal range for warm water species along with slightly alkaline pH. It was found that Lake Hertale is home to four important fish species, namely, Nile Tilapia (Oreochromis niloticus), barbs (Lebobarbus intermidus), African catfish (Clarias gariepinus) and Common carp (Cyprinus carpio), Nile crocodiles, several species of birds and hippopotamus. Labeobarbus constituted 56%, followed by Nile tilapia with 31% of the total population. The African Catfish constituted only 9% of the catch. The mean lengths of African Catfish and Labeobarbus were 47.2 and 38 cm respectively. The mean lengths of Nile tilapia and Common carp were 22.8 and 21.7 cm respectively. The fish production potential of the lake was estimated from 94.3 to 238 tons per year, with an average production of 145.7 tons per year. The estimate production potential can support up to 21 to 28 fishers, with an average number of 25 fishermen to sustainably utilize the lake's fishery potential. Lake Hertale and other adjacent lakes in the Afar region of Ethiopia can complement to the fight against hunger and malnutrition. Besides, through appropriate fishery development intervention, it is possible to create employment for the predominantly pastoralist Afar community.

In this study we explain the concepts, determinants and imperatives of boundary in smallholder producers' cooperatives both conceptually and empirically. The conceptual framework indicates the importance of the type of goods (being a club good or not) and range of activities that a cooperative provides to its members in defining a competitive boundary. Using unique organisational and market level data from Ethiopia, we then test empirically whether the observed (weak) performance of producers' cooperatives in Africa is explained by their organisational boundary – the type and range of goods or services they provide to members. The empirical results confirm that the competitiveness of producers' cooperatives is significantly correlated with the type and number of services – i.e. cooperatives that provide club goods and a limited range of services are found to be more competitive. The results also suggest that a considerable number of cooperatives in Ethiopia engage in markets where they do not have competitive advantage. Overall, we demonstrate the importance of properly defining a viable boundary – proper selection of services (or markets) and limiting the range of services – for improving the competitiveness of membership‐based producer cooperatives in Africa. [ABSTRACT FROM AUTHOR]

Pesticides are chemicals used to control different types of pests. Though pesticides played a role in improving the quantity and quality of production, they have been threatening ecosystems and posed effects on humans in different parts of the world. Unfortunately, there were no studies made about the effects of pesticide residues on ecosystems and consumers in the Fogera District of Amhara Region, Ethiopia. Hence, the main objective of this study was to understand the knowledge, attitude, and practices of respondents about the effects of pesticide residues on ecosystems and consumers. A cross-sectional survey complemented by focus group discussions and field observations was used to gather the required data for the study. The close-ended data were analyzed using descriptive statistics, logistic regressions, and independent t-test, and data from open-ended questions were grouped and summarized based on their similarities. The findings of the study confirmed that there was significant knowledge, attitude, and practices difference between farmers and consumers about the effects of pesticide residues on ecosystems and humans. Farmers used highly toxic pesticides to control pests and improve the glossiness of vegetables and khat. Though they didn't use the sprayed vegetables for their home consumption, some of the farmers deliberately supplied pesticide-sprayed vegetables without worrying about the negative effects of the pesticides on the consumers. There were also fishing practices from rivers after intoxicating the fish using the pesticide sprayed feed. This, in turn, might poison individuals who consume the fish. In general, pesticide application practices and consumption of pesticide-sprayed foodstuffs and surface water might pose serious health risks to ecosystems and humans. To minimize the negative effects of pesticides, rigorous awareness-raising on the effects and management of pesticides, enforcement of laws, delineation of the pesticide free buffer zone for waters, the establishment of a clear pesticide supply chain to the end users, ecosystem assessment and food safety monitoring schemes are highly required.

The purpose of this study was to assess the effect of emodin on biochemical variables, antioxidant activity, heat shock protein gene expression and prawn intestinal morphology (Macrobrachium rosenbergii). Three feeds containing 0 mg kg–1 (T1, control group), 25 mg kg–1 (T2) and 50 mg kg–1 (T3) of emodin were formulated and fed for eight weeks. Alanine aminotransferase, total cholesterol and triglyceride contents were significantly lowered although glucose tended to increase following the emodin remedy. Superoxide dismutase variables in haemolymph were dramatically upgraded, whilst malondialdehyde and superoxide anion situations were significantly lowered when compared to control. Emodin supplementation had no influence on glutathione peroxidase contents. Emodin remedy dropped the expression of HSP60 and HSP90 genes in comparison to the control. In T2, the intestinal epithelial cells were complete, well-organised and tightly affixed to the basement membrane, in discrepancy to the slightly disunited basement membrane in the control group. The emodin-treated prawn individuals had a thicker and full intestinal morphology than the control groups. Supplementation with emodin at dosages of 25 mg kg–1 improved growth performance, blood biochemical, antioxidant capacity and immune gene expression.

EFL teacher-educators and teachers are seen as ignorant of teaching aural skills for referring to resource shortages is a common mechanism for their scapegoating. It hinders students’ opportunity to boost oral proficiency in the abundance of their smartphones in the classrooms to learn aural and oral skills. Hence, Moodle 3.0, a learning application, was used to create and deliver aural comprehension lessons by customizing audiovisual texts on social media to practice oral skills. A one-group-only quasi-experimental, Interrupted Time Series Design was employed to investigate the effect of mobile-based aural comprehension lessons on the general and specific oral skills’ performances of the preservice teacher trainees at Arba Minch Teacher Education College in Ethiopia. A total of 25 trainees of the 3-year diploma program were taken comprehensively as samples. To analyze data quantitatively, in addition to descriptive methods, Kruskal-Wallis, and Wilcoxson’s Signed Rank Tests were run to inferentially determine the significance of differences in the effects across the oral sub-skills and on the trainees’ general oral performance, respectively. Thus, the results disclosed that mobile-based aural oral skill lessons had positive significance in the trainees’ general oral performance without significant differences in the effects in performance across the oral sub-skills. Finally, the researchers recommended others to investigate and minimize first language interference and pronunciation problems of EFL learners. The EFL teacher trainees’ learning styles should also be further studied to understand the effect of mobile-based aural-oral skill lessons on their EFL learning/studying habits after the exposure to mobile-based lessons.

Alumina nanoparticles were prepared by sol-gel method, where the obtained nanosize was 35 nm, and the nanomaterial was coated with PVP polymer, where the nanomaterial was dispersed by ultrasonic waves for half an hour, and then, the polymer was added, and under high magnetic stirring for 24 hours, it was dried at a temperature of 60°C for 24 hours. Cadmium salt solutions were prepared with different concentrations of 10, 30, and 60 ppm, and the nanomaterial was immersed in the prepared solutions at different times of 10, 30, and 60 minutes, and the measurement was done by an atomic absorption device. By means of the electronic scanner, a difference appeared in the nanosize, and this indicates that the packaging has completely occurred.

Background Previous studies were conducted only on elite athletes, and they investigate acute training responses of cardiac troponin I (CTnI). However, cardiac troponin was found to be elevated in young and inexperienced athletes than adults, and immature myocardium is more susceptible to injury, which needs further consideration.Aim Therefore, we aimed to observe the association between CTnI and cardiovascular parameters in response to chronic endurance training adaptation in young athletes.Methods Fifteen participants aged (19.5±1.3) years were selected and placed in endurance running at 70%–80% HRmax intensity for 35 min per training for the first week and additional 2 min each week from the second to the last week for 12 weeks. Serum cardiac troponin and cardiovascular parameters were assessed at pre-training and after 12 weeks of training.Result We find a significant CTnI level (p

Müllerian abnormalities are present in 0.17% of fertile women and 3.5% of infertile women, and a unicornuate uterus is observed in 0.4% of women. The uterus is normally formed during embryogenesis by the fusion of the two Müllerian ducts. If one of the ducts does not develop, only one Müllerian duct contributes to the uterine development. We report a case of Gravida II, abortion I referred from a primary hospital with a referral paper and sonography stating she had IUFD. She had regular antenatal care follow-up at the primary hospital and had 8 months of amenorrhea. Our ultrasound assessment confirmed the intrauterine fetal demise, but the rudimentary horn pregnancy was missed. Repeated attempts at the induction of labor were tried but unsuccessful. The diagnosis was confirmed at laparotomy. She underwent cesarean section with right intact rudimentary horn removal. A nonviable male fetus with birth weight of 1.2 kg was delivered. Women with this abnormality are asymptomatic and unaware of having a unicornuate uterus. Abdominal pain is the most common presenting symptom with the rudimentary horn, but communicating horn pregnancy is generally asymptomatic in early pregnancy. Early awareness of this rare clinical condition is so crucial especially in developing countries where the availability of new technologies is scarce to explore uterine abnormalities. The patient had uneventful postoperative recovery and was discharged after 3 postoperative days.

Background Endurance training in varied intensity zones are more likely to show different adaptive responses. However, it is still unclear the intensity level of endurance exercise in junior young athletes that may promote increased markers for cardiorespiratory and cardiometabolic response. Therefore, we aimed to investigate the effect of 1 week different intensity endurance training on markers of cardiorespiratory and cardiometabolic response in young athletes.Methods Thirty apparently healthy male young athletes averaging 19.4±1.3 years of age were recruited and randomly assigned to two different intensity endurance training groups. The first group trained at 60% to 70% maximum heart rate (HRmax) for 45 min per session and the second group trained at 70% to 80% HRmax for 30 min per session for a period of 1 week three sessions per week. A pre-training and post-training, marker of cardiorespiratory and cardiometabolic response was assessed for both groups.Results Both intensity training had no significant effect on markers of cardiorespiratory response within and between training groups (p>0.05). Whereas, cardiometabolic markers lactate dehydrogenase (p=0.001), cardiac troponin I (p=0.001) and creatinekinase myocardial band (p=0.001) significantly increased at the end of 1 week within the group in both training groups (p≤0. 05). In the comparative analysis between groups, there was no significant difference in markers of cardiometabolic response (p>0.05).Conclusion 1 week 60% to 70% HRmax and 70% to 80% HRmax intensity zones induces similar acute effects on markers for cardiometabolic and cardiorespiratory responses between groups and significant elevations of cardiometabolic markers within the groups in moderately trained young athletes.

Background The influence of endurance training intensity and adaptation on serum cardiac markers is poorly understood and controversial; however, no enough data observed the association of serum cardiac markers with VO2max. Therefore, we aimed to investigate whether serum cardiac markers are associated with maximum oxygen consumption (VO2max) in response to 12-week endurance training on amateur athletes.Methods 15 apparently healthy male amateur athletes with 19.47 ± 1.30 years of age were recruited and participated in endurance training with 70%–80% maximal heart rate intensity for 35 min per session for the first week and 2 min increments each week from the second to the last week for a period of 12 weeks. VO2max and serum cardiac markers (lactate dehydrogenase [LDH], creatine kinase myocardial band (CK-MB) and cardiac troponin I [CTnI]) were assessed at the beginning of the training and after 12-week endurance training.Results The result of CTnI indicated significantly (p < 0.01) and inversely (r = − 0.466) correlated with VO2max and CK-MB indicated significantly (p < 0.01) and inversely associated with VO2max (r = − 0.536) with moderate relationship. However, we did not find a significant association on LDH (p > 0.05) with VO2max in response to endurance training adaptation.Conclusion Our finding confirms our hypothesis that serum cardiac markers are inversely associated with estimated VO2max in response to endurance training adaptation.

Orphans face multiple challenges including insufficient food, shelter, schooling, and medical care. Most research on orphans in developing countries concentrates on nutrition and health status. The present study aims to explore the psychological wellbeing of in-school orphaned and non-orphaned children.A comparative cross-sectional study design was used in 370 randomly selected children aged between 10 and 18. Two rosters (one for orphans and one for non-orphans) were created, and then 185 were selected from each roster. Trained field workers used structured questionnaires to obtain information from participants. An adapted Ryff Psychological Wellbeing Scale was used to measure psychological wellbeing. Mean scores were determined for each dimension and for total psychological wellbeing. The mean split was used to divide psychological wellbeing into "high" and "low". Data were coded, entered, cleaned, and analyzed using SPSS version 20. The independent sample t-test was used to determine statistically significant differences in psychological wellbeing between orphaned and non-orphaned children. P values < 0.05 were deemed statistically significant.Of 370 children, 185 (50%) were orphans. Among orphaned children, only 62 (33.5%) scored high on the total psychological wellbeing scale whereas 107 (57.8%) of their non-orphaned peers scored highly. The non-orphaned children had about 10.8 higher mean psychological wellbeing scores than their orphan counterparts (P

Effective management is essential for small-scale fisheries to continue providing food and livelihoods for households, particularly in developing countries where other options are often limited. Studies on the population dynamics and stock assessment on fishery target species are thus imperative to sustain their fisheries and the benefits for the society. In Lake Koka (Ethiopia), very little is known about the vital population parameters and exploitation status of the fishery target species: tilapia Oreochromis niloticus,common carp Cyprinus carpióand catfish Clarias gariepinus.Our study, therefore, aimed at determining the vital population parameters and assessing the status of these target species in Lake Koka using length frequency data collected quarterly from commercial catches from 2007-2012. A total of 20 097 fish specimens (distributed as 7 933 tilapia, 6 025 catfish and 6 139 common carp) were measured for the analysis. Von Bertalanffy growth parameters and their confidence intervals were determined from modal progression analysis using ELEFAN I and applying the jackknife technique. Mortality parameters were determined from length-converted catch curves and empirical models. The exploitation status of these target species were then assessed by computing exploitation rates (E) from mortality parameters as well as from size indicators i.e., assessing the size distribution of fish catches relative to the size at maturity (L m),the size that provides maximum cohort biomass (Lopt) and the abundance of mega-spawners. The mean value of growth parameters L x, Kand the growth performance index 0' were 44.5 cm, 0.41/year and 2.90 for O. niloticus,74.1 cm, 0.28/year and 3.19 for C. carpioand 121.9 cm, 0.16/year and 3.36 for C. gariepinus,respectively. The 95 % confidence intervals of the estimates were also computed. Total mortality (Z) estimates were 1.47, 0.83 and 0.72/year for O. niloticus, C. carpioand C. gariepinus,respectively. Our study suggest that O. niloticusis in a healthy state, while C. gariepinusshow signs of growth overfishing (when both exploitation rate (E)and size indicators were considered). In case of C. carpio,the low exploitation rate encountered would point to underfishing, while the size indicators of the catches would suggest that too small fish are harvested leading to growth overfishing. We concluded that fisheries production in Lake Koka could be enhanced by increasing Etoward optimum level of exploitation (E opt)for the underexploited C. carpioand by increasing the size at first capture (Lc)toward the L opt range for all target species.

Generally, land fragmentation is a universal trait of all agricultural systems which affects farmland productivity and no one had documented a rural society where there was no land fragmentation. Hence, this study sought to ascertain the effects of land fragmentation on farmland productivity in the highland districts of Northwestern Ethiopia by using cross-sectional data collected from 240 respondents during 2015/16 production seasons and analyzed by using linear and Cobb-Douglass production functions. In land productivity model, 38% of variations in farmland productivity are explained by variations in independent variables including land fragmentation parameters. Average farmland size of 1.25 ha was obtained as minimum size that can generate minimum food and cash requirement of an average family of five adult equivalents. Hence, the government should come up with land use policy and population growth controlling program, which enables determining minimum economic farmland size, improving land productivity, and finding ways to strengthen off-farm activities and livestock sector to absorb more labor and enhance means of generating more income so as to decrease minimum farmland size required.

Background: Stroke is rapidly developing clinical signs of focal/ global disturbance of cerebral function, with symptoms lasting more than 24 h and leading to death. Data showed that stroke deaths in Ethiopia reached nearly seven percent of total deaths. Despite this report, there is a paucity of investigations about the problem., Objective: To determine in-hospital mortality and its associated factors among hospitalized stroke patients in Hiwot Fana Comprehensive Specialized University Hospital and Jugal General Hospital, eastern Ethiopia from September 2016-August 2022 G.C., Methods: A retrospective cohort study was conducted among hospitalized stroke patients. A sample size of 395 medical records was selected from a total of 564 stroke patients by a simple random sampling technique. The data was analyzed by SPSS version 26 using bivariable and multivariable cox-regression models. A p-value of 0.05 and less at a 95% confidence interval was used to establish a statistically significant association., Results: Of the total, 109 (27.6%) died in the hospital while 57.2% and 15.2% of them were discharged with improvement and against medical advice, respectively. Age greater than 65 (AHR = 4.71, 95% CI = 1.11-19.96), creatinine level > 1.2 mg/dl (AHR = 1.54, 95% CI = 1.0-2.39), and co-morbidity with atrial fibrillation (AHR = 1.48, 95% CI = 1.0-2.21) were significantly associated with in-hospital mortality., Conclusion: In-hospital mortality was found in more than a quarter of stroke patients. Mortality was more likely increased among the patients with age > 65, serum creatinine level > 1.2 mg/dl, and atrial fibrillation. Hence, these high-risk patients need to be monitored., (© 2024. The Author(s).)

Background: Venous thromboembolism is the third most common cause of cardiovascular death and is responsible for more than 3 million deaths annually worldwide. Despite high rates of morbidity and mortality associated with venous thromboembolism, limited studies have been conducted on in-hospital mortality and its associated factors in Ethiopia, particularly in study settings., Objective: To assess in-hospital mortality and associated factors among patients admitted with venous thromboembolism at selected public hospitals of Harar town, Eastern Ethiopia, from 10 March 2018 to 8 March 2022., Methods: A retrospective cohort study design was conducted among 502 patients admitted with venous thromboembolism at Hiwot Fana Comprehensive Specialized Hospital and Jugal General Hospital using a simple random sampling technique. Data extraction formats were used to collect data from patient medical record cards. Then data were coded and entered into EpiData version 3.1 computer programs and exported to SPSS version 26 for analysis. Bivariate and multivariate backward Cox regression analysis was used to verify the associated factors of in-hospital mortality among venous thromboembolism patients. A p -value of less than 0.05 at a 95% confidence interval was used to establish a statistically significant association., Results: A total of 502 patient medical record cards with outcome variables were included in the study. More than half of the patients 350 (69.7%) were females. Among the 502 patients who were admitted with venous thromboembolism, 8.2% (95% CI: 5.6-10.6) of patients had in-hospital mortality. DM (AHR = 4.28, 95% CI: 1.80-10.15, p  = 0.001) and unfractionated heparin duration (AHR = 10.26, 95% CI: 2.45-43.01, p  = 0.001) were statistically significant association with venous thromboembolism mortality., Conclusion: Approximately 8.2% of venous thromboembolism patients died in the hospital. Diabetes and heparin were independently associated with higher mortality. Therefore, it is better to give more attention to the patients co-morbid with diabetes mellitus and for unfractionated heparin treatment duration to reduce venous thromboembolism mortality., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2024.)

Background: Maternal and neonatal mortality is a global problem that is highly prevalent in low- and middle-income countries, including Ethiopia. Maternal delay in seeking institutional delivery services utilization plays a significant role in determining maternal and neonatal health outcomes. Although studies have been conducted on institutional delivery service utilization in Ethiopia, little is known about factors for delays in seeking care for institutional delivery services., Objective: This study aimed to assess the delay in seeking institutional delivery services and associated factors among immediate postpartum mothers in public health facilities in Gondar, northwest Ethiopia., Methods: A facility-based cross-sectional study was conducted from July 15 to September 10, 2022. A total of 391 participants were selected using systematic random sampling. Data were collected through face-to-face interviews using structured, pretested, and interviewer-administered questionnaires. Data were entered into EpiData version 4.6, and the analysis was conducted using Statistical Package for Social Science version 26. The multivariable logistic regression model was fitted and the level of significance was set at p ≤ 0.05., Result: The prevalence of delay in seeking institutional delivery was 49.10% (95% confidence interval [CI]: 44.13, 54.08). Rural residence (adjusted odds ratio [AOR] = 2.51; 95% CI: 1.43-4.41), no antenatal care visits (AOR: 2.87; 95% CI: 1.34-6.13), unplanned pregnancy (AOR: 2.98; 95% CI: 1.78-5.01), poor decision-making autonomy in maternity care services (AOR: 1.98; 95% CI: 1.15-3.40), and poor birth preparedness plan (AOR: 4.88; 95% CI: 2.79-8.53) were significantly associated with delays in seeking institutional delivery., Conclusion: Delays in seeking institutional delivery services were high. It is better to promote women's decision-making power in their own health care. In addition, it is better to arrange programs that will improve maternal and child health service utilization., (© Tazeb Alemu Anteneh et al., 2024; Published by Mary Ann Liebert, Inc.)

Background: Diarrhea is a serious health problem in children under the age of five that is both preventable and treatable. In low-income countries like Ethiopia, children under the age five years frequently experience diarrhea. However, the burden and associated factors of these diarrheal diseases are understudied in Eastern Ethiopia, Thus, this study aimed to determine the factors associated with the prevalence of diarrheal diseases in Eastern Ethiopia from September 1-30, 2022., Methods: A cross-sectional study was conducted on the total of 602 children aged 6 to 59 months in Oda Bultum district in eastern Ethiopia. A multistage sampling method was used. Three kebeles were selected from nine kebeles by the lottery method. Data was entered into Epi data 4.0.2 and exported to SPSS version 21 for analysis. Descriptive analysis was used for frequency, mean, and standard deviations. In addition, bivariable, and multivariable Poisson regression model was used to identify predictors of diarrhea along with a 95% confidence interval. Finally, statistical significance was declared at a p-value of 0.05., Result: A total of 602 children were included in this study. The prevalence of diarrhea 7.4% (47/602), 95% CI; 5.5-9.7%) among the children. Factors such as being unvaccinated for any vaccine (AOR = 10.82, 95%CI; 4.58-25.48) and born from a mother who had medium level of empowerment (AOR = 0.34, 95%CI; 0.11-0.88) in the household had statistically significant association with diarrhea among the children compared to their counterparts., Conclusion: The study found that nearly one out of thirteen children aged 6 to 59 months had any form of diarrheal diseases in Oda Bultum District, Eastern Ethiopia. In addition, the study revealed that children who were vaccinated for their age developed diarrhea less likely compared to those who did not receive any form of vaccine for their age. Moreover, children with mothers who had a medium level of empowerment were less likely to get diarrhea than children with mothers who had a low level of empowerment., (© 2024. The Author(s).)

Nutrient management research was conducted across locations to investigate the influence of landscape position (hill, mid-, and foot slope) in teff ( Eragrostis tef ) and wheat ( Triticum aestivum ) yield response to fertilizer application and liming in the 2018 and 2019 cropping seasons. The treatments included 1) NPS fertilizer as a control treatment (42 N + 10P + 4.2S kg ha -1 for teff and 65 N + 20P + 8.5S kg ha -1 for wheat); 2) NPS and potassium (73 N + 17P + 7.2S + 24 K kg ha -1 for teff and 103 N + 30P + 12.7S + 24 K kg ha -1 for wheat) and 3) NPSK and zinc (73 N + 17P + 7.2S + 24K + 5.3Zn kg ha -1 for teff and 103 N + 30P + 12.7S + 24K + 5,3Zn kg ha -1 for wheat) in acid soils with and without liming. Results showed that the highest teff and wheat grain yields of 1512 and 4252 kg ha -1 were obtained at the foot slope position, with the respective yield increments of 71% and 57% over the hillslope position. Yield response to fertilizer application significantly decreased with increasing slope owing to the decrease in soil organic carbon and soil water content and the increase in soil acidity. The application of lime with NPSK and NPSKZn fertilizer increased teff and wheat yields by 43-54% and 32-35%, respectively compared to the application of NPS fertilizer without liming where yield increments were associated with the application of N and P nutrients. Orthogonal contrasts revealed that landscape position, fertilizer application, and their interaction effects were significant on teff and wheat yields. Soil properties including soil pH, organic carbon, total N, and soil water content were increased down the slope, which might be attributed to sedimentation down the slope. However, available P is yet very low both in acidic and non-acidic soils. We conclude that crop response to applied nutrients could be enhanced by targeting nutrient management practices to agricultural landscape features and addressing other yield-limiting factors such as soil acidity and nutrient availability by conducting further research., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper, (© 2023 The Authors.)

Objective: Inappropriate antimicrobial use leads to drug resistance and poor clinical outcomes. Considering the lack of data regarding the drug use patterns in the treatment of pneumonia in selected study areas, the authors felt compelled to assess the appropriateness of antimicrobial usage in the treatment of pneumonia at Hiwot Fana Specialized Comprehensive University Hospital and Jugal Hospital from May 1 to 31, 2021., Methods: A cross-sectional retrospective study was conducted using the medical cards of 693 admitted patients with pneumonia. The collected data were analyzed using SPSS version 26. Bivariable and multivariable logistic regression analyses were used to identify the factors associated with an initial inappropriate antibiotic use. A p value of 0.05 was used to determine the statistical significance of the association using an adjusted odds ratio with 95% confidence interval., Results: Of the total participants, 116 (16.74%, 95% confidence interval: 14.1-19.6) of them received an initial inappropriate antimicrobial regimen. Ceftriaxone plus azithromycin was the most prescribed antimicrobial agent. Patients who were younger than 5 years (adjusted odds ratio = 1.71; 95% confidence interval: 1.00-2.94), between 6 and 14 years (adjusted odds ratio = 3.14; 95% confidence interval: 1.64-6.00), and older than 65 years (adjusted odds ratio = 2.97; 95% confidence interval: 1.07-2.66), with comorbid conditions (adjusted odds ratio = 1.74; 95% confidence interval: 1.10-2.72) and prescribed by medical interns (adjusted odds ratio = 1.80; 95% confidence interval: 1.14-2.84) were associated with an initial inappropriate antimicrobial use., Conclusion: Around one out of every six patients had received initial inappropriate treatments. Adherence to the recommendation of guidelines and attention to extreme-aged groups and comorbidity may improve antimicrobial use., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.)

Objective: Although there is a high risk of drug resistance, empiric treatment is a common approach for pneumonia management. In this respect, it is relevant to know treatment outcomes of patients with pneumonia. This study aimed to assess treatment outcomes and its associated factors among pneumonia patients treated at two public hospitals in Harar, eastern Ethiopia., Design: Retrospective follow-up study., Setting: Jugal General Hospital and Hiwot Fana Specialised University Hospital in Harar, eastern Ethiopia., Participants: Patients admitted and treated for pneumonia in the two public hospitals in eastern Ethiopia between April 2020 and April 2021., Primary Outcome: The primary outcome was unfavourable treatment outcome (died or transferred to intensive care unit) for pneumonia patients., Results: A total of 693 patients with pneumonia were included in the study. 88 (12.7%) of these patients had an unfavourable treatment outcome, which included 14 (2%) transfers to the intensive care unit and 74 (10.7%) deaths. Patients with comorbidity (adjusted OR, AOR=2.96; 95% CI: 1.47 to 5.97) and with clinical features including abnormal body temperature (AOR=4.03; 95% CI: 2.14 to 7.58), tachycardia (AOR=2.57; 95% CI: 1.45 to 4.55), bradypnoea or tachypnoea (AOR=3.92; 95% CI:1.94 to 7.92), oxygen saturation below 90% (AOR=2.52; 95% CI:1.37 to 4.64) and leucocytosis (AOR=2.78, 95%, CI:1.38 to 5.58) had a significantly increased unfavourable treatment outcome., Conclusion: We found that nearly one out of eight patients with pneumonia had unfavourable treatment outcomes. It was considerably high among patients with comorbidities and apparent abnormal clinical conditions. Therefore, taking into account regionally adaptable intervention and paying close attention to pneumonia patients admitted with comorbidity and other superimposed abnormal conditions might help improve the treatment outcomes of these populations., Competing Interests: Competing interests: The authors declared that they have no competing interests with this work., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

At the current times, soil erosion is the major problem that affects land and water resources, especially in Ethiopia's highlands. Due to the dynamics of land use land cover change, land degradation, and soil erosion increase significantly and result in a loss of fertile soil every year and lead reduction in agricultural production. This study was therefore designed to explore the land use land cover (LULC) dynamics from 1986 to 2020, to estimate mean annual soil erosion rates and identify erosion hotspot areas from 1986 to 2020, and finally, to evaluate the impacts of land use land cover change on soil loss of 1986 to 2020. For this, Landsat imageries of 4 years from 1986 to 2020 were used. Maximum likelihood supervised classification methods were used to classify LULCs. The dynamics of LULC change were used as an input for measuring soil loss by employing the combination of geospatial technologies with the revised universal soil loss equation (RUSLE). The LULC maps of 1986, 1997, 2009, and 2020 were used for identifying crop management (C) factor and conservation practice (P) factor. Rainfall erosivity factor (R), soil erodibility factor (K), and slope length and steepness factor (LS) were also used as sources of data. Based on the five factors, soil erosion intensity maps were prepared for each year. Results showed that the annual soil loss in the watershed ranged from 0 to 3938.66 t/ha/year in 1986, 0 to 4550.94 t/ha/year in 1997, 0 to 5011.21 t/ha/year in 2009, and 0 to 6953.23 t/ha/year in 2020. The annual soil loss for the entire watershed was estimated at 36.889, 42.477, 47.805, and 48.048 t/ha/year in 1986, 1997, 2009, and 2020, respectively. The mean soil loss of 1986, 1997, 2009, and 2020 was higher in cultivated land followed by shrub land, grazing land, and forest land. Mean soil loss increased from 1986 to 1997, from 1997 to 2009, and from 2009 to 2020. This is because of the expansion of agricultural land at the expense of grazing land and shrub land. Therefore, urgent soil and water conservation practices should be made in hotspot areas., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Background: Hypertensive crisis is a significant global health issue that raises the costs to healthcare systems and requires specific attention to improve clinical outcome. There is scarce information on hypertensive crisis cases treatment outcome in the study setting., Objective: This study aimed to assess treatment outcome and associated factors among patients admitted with hypertensive crisis at Public Hospitals in Harar Town, Eastern Ethiopia., Methods: A cross-sectional study was conducted among 369 hypertensive crisis patients who had been admitted to the emergency department of Hiwot Fana Comprehensive Specialized Hospital and Jugol General Hospital from May 1, 2017, to May 1, 2022. All hypertensive crisis patients who fulfilled the inclusion criteria were included. The data were extracted from medical records using a data abstraction format. The collected data were analyzed using Statistical Package for Social Sciences version 22. Binary logistics regression model using bivariate and multivariable analysis with 95% confidence intervals and P -values were used to determine the association between variables., Results: The medical records of 369 patients in total were reviewed. Of these, the medical records of 363 patients contained all the necessary information and were used in the study. More than half of the patients (238; 65.6%) were males. Among 363 patients admitted with hypertensive crisis, 98 (27.0%, 95% Confidence Interval (CI):22.5%-31.9%) of them had poor treatment outcome of hypertensive crisis. Being female (Adjusted Odds Ratio (AOR)=3.4; 95% CI=1.7-7.9), residing in rural areas (AOR=2.4; 95% CI=2.7-5.1), taking captopril during admission (AOR=5.6; 95% CI=2.4-7.9), taking antihypertensive treatment before admission (AOR=0.5; 95% CI=0.2-0.9), and being non compliant to treatment (AOR=2.7; 95% CI=1.4-3.5) had statistically significant associations with poor treatment outcome of hypertensive crisis compared to their counterparts., Conclusion: The magnitude of poor treatment outcome of hypertensive crisis was high. Sex, residence, non-compliance, and type of emergency drug administered during admission were substantially related with poor treatment outcome of hypertensive crisis. Health professionals should put great emphasis on emergency drugs administered during admission to achieve the desired outcome., Competing Interests: The authors declare that they have no competing interests in this work., (© 2022 Samuel et al.)

Background: During menstruation, school girls face obstacles connected to menstrual hygiene management in schools. Due to their monthly period, up to 20% of girls miss school globally, and one in ten will drop out entirely. Three hundred thirty-five million girls attended school without access to running water or soap. In Ethiopia, 67% of girls have no access to education on puberty and menstrual health; menstrual hygiene management continues to be one of the major problems among school girls. Thus, context-specific assessment of the practice may be useful in developing customized intervention approaches. Thus, the objective of the study was to assess practices of menstrual hygiene management and associated determinants among secondary school girls in East Hararghe, Ethiopia from 1 to 30 December 2020., Methods: A school-based cross-sectional survey was undertaken with 486 randomly selected female students. Data were collected by pretested self-administered questionnaire. Descriptive statistical tests and multivariate logistic regression were used to describe the study variables and to examine the association. Statistical package for social science version 23 was used for data analysis, and a p -value of 0.05 was considered as a cut-off point for statistical significance., Results: Of the total, 328 (68%) of the study participants practiced appropriate menstrual hygiene. Besides, 350 (72.6%) had a good level of understanding about menstrual hygiene. A higher level of knowledge (adjusted odds ratio = 2.12, 95% confidence interval = 1.28, 3.53), a greater wealth indexed family (adjusted odds ratio = 7.14, 95% confidence interval = 3.98, 12.88), earning permanent pocket money (adjusted odds ratio = 0.495, 95% confidence interval = 0.299, 0.821), and being in grade level (11-12) (adjusted odds ratio = 3.45, 95% confidence interval = 1.75, 4.501) were significant predictors of the good menstrual hygiene practice., Conclusion: One-third of the school girls had poor menstrual hygiene practices which may affect their school performance and the reproductive health. Hence, tailored menstrual hygiene information should be given to school girls and parents. Besides, efforts ought to be made for the provision of affordable sanitary materials in schools.

Introduction: Drug use evaluation is a method of obtaining information to identify problems related to drug use and if properly developed, a means of correcting the problems. Ceftriaxone is among the most commonly utilized cephalosporins. Owing to a broad spectrum of activity and being used empirically, ceftriaxone has been used inappropriately posing a risk for development of antimicrobial resistance. This study is, therefore, designed to evaluate the appropriateness of ceftriaxone utilization in government hospitals in Harar town., Methods: A retrospective cross-sectional study was conducted in four government hospitals of Harar town by reviewing the medical records of 271 patients who received ceftriaxone from 1 January to 31 December 2016. Systematic random sampling was utilized to capture the medical records. Data were entered and analyzed using SPSS version 22., Results: From the 271 medical records reviewed majority of patients were from surgical ward ( n  = 85, 31.4%) followed by gynecology and obstetrics ward ( n  = 67, 24.7%). Demographically, the majority of the patients were female ( n  = 142, 52.4%). Patients in the age group of 20-29 years were dominant ( n  = 98, 36.2%). A total of 71 drugs were co-administered with ceftriaxone, the most common being metronidazole followed by tramadol. Among the co-administered drugs, unfractionated heparin ( n  = 6), warfarin ( n  = 5), and enoxaparin ( n  = 1) were found to have a moderate drug interaction with ceftriaxone. Ceftriaxone was commonly used for post-operative prophylaxis ( n  = 80, 27.5%) followed by for the management of pneumonia ( n  = 62, 21.3%). The result of ceftriaxone use evaluation showed that majority ( n  = 190, 70.1%) were found to be inappropriate. The inappropriate utilization was primarily due to wrong indication (indications for which ceftriaxone was not the primary option) ( n  = 114, 60.0%) followed by wrong duration ( n  = 54, 28.4%)., Conclusion: Ceftriaxone was used inappropriately in more than two-thirds of the patients, with wrong indication and wrong duration contributing the majority. Inappropriate use of antibiotics may potentially lead to the emergence and spread of drug-resistant microorganisms and also ultimately exposes the patient to treatment failure, prolonged hospital stay, and higher cost of therapy., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2021.)

This study was conducted to evaluate the effectiveness of best management practices (BMPs) to reduce soil erosion in Gumara watershed of the Abbay (Upper Blue Nile) Basin using the Soil and Water Assessment Tool (SWAT) model. The model was calibrated (1995-2002) and validated (2003-2007) using the SWAT-CUP based on observed streamflow and sediment yield data at the watershed outlet. The study evaluated four individual BMP Scenarios; namely, filter strips (FS), stone/soil bunds (SSB), grassed waterways (GW) and reforestation of croplands (RC), and three blended BMP Scenarios, which combines individual BMPS of FS and RC (FS & RC), GW and RC (GW & RC), and SSB and GW (SSB & GW). Mean annual sediment yield at the baseline conditions was estimated at 19.7 t ha -1 yr -1 , which was reduced by 13.7, 30.5, 16.2 and 25.9% in the FS, SSB, GW, and RC Scenarios, respectively at the watershed scale. The highest reduction efficiency of 34% was achieved through the implementations of the SSB & GW Scenario. The GW & RC, and FS & RC Scenarios reduced the baseline sediment yield by 32% and 29.9%, respectively. The study therefore concluded that the combined Scenarios mainly SSB & GW, and GW & RC can be applied to reduce the high soil erosion in the Gumera watershed, and similar agro-ecological watersheds in Ethiopia. In cases where applying the combined scenarios is not possible, the SSB Scenario can yield significant soil erosion reduction.

Coronavirus disease in 2019 emerged in Wuhan, Hubei Province, China, in December 2019. After a month, it was declared a global threat to public health. The effects of the pandemic could be socio-economic, undermining the health system and risking livelihoods. Vulnerability to this infection has been associated with underlying comorbidities such as hypertension, diabetes, coronary heart disease, chronic respiratory diseases, cancer, and compromised immune systems. Co-morbidity has been common to the elderly, the disabled, and the homeless. In addition, more severe coronavirus disease outcomes have been reported in older males than females. Nonetheless, multiple variables are related to the concept of cultural gender that should be taken into account as women in more affected sectors are economically disadvantageous and over-represented. Similarly, although children are not the face of this pandemic, calamity has a profound effect on their welfare, especially for those living in poor and inconvenient situations. Moreover, the economic influence could be profound and universal when viewed through a migration lens as it is exacerbating xenophobic and discriminatory treatment. Protection measures to mitigate the outbreak of a pandemic, such as social distancing, may reduce social support for certain categories relied on for their day-to-day activities. The mental health of people would definitely be affected by the additional psychosocial burden of the pandemic, particularly in vulnerable groups. Integrated approaches are therefore mandatory to assist these groups and contain the pandemic., Competing Interests: The authors declare that the perspective document was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Gashaw, Hagos and Sisay.)

Background: Urinary tract infection is a common infection posing a significant healthcare burden globally. Currently, it is becoming hard to manage due to the drug resistance of uropathogens. This study aimed to evaluate the rate of culture positivity and the susceptibility pattern of isolates among clinically diagnosed patients with urinary tract infection., Methods: An institution-based cross-sectional study was conducted on patients clinically diagnosed with urinary tract infections and received a drug prescription at Hiwot Fana Specialized University Hospital from August 2018 to June 2019. A clean-catch mid-stream urine specimen was collected and bacterial identification and susceptibility test were performed using standard microbiological methods. Data were entered into EpiInfo 7 and exported to STATA 15 for analysis. Data were analyzed using descriptive analysis and bi-variate and multivariate regression analyses and presented with graphs, frequency, and tables., Results: A total of 687 urine samples were collected from patients with clinically diagnosed urinary tract infections. The mean age was 31 years and 56.62% were female. 28.38% of the participants had a culture-positive result, of which 86.15% had monomicrobial infections. Inpatients (AOR = 3.8, 95% CI = (1.8-7.9)) and hypertensive patients (AOR = 2.1, 95% CI = (1.1-4.4)) had higher odds of culture-positive results. Staphylococcus species (35.3%), E. coli (25.34%), Pseudomonas species (6.8%), and other Enterobacterales are isolated. Most isolates showed resistance to more than one drug, and amikacin, gentamicin, and nitrofurantoin showed relatively higher activity against isolates., Conclusion: About one-third of the clinically diagnosed patients with urinary tract infection were culture-positive with many types of bacterial uropathogens. Inpatients and hypertensive patients had a higher risk of developing bacterial infections. Bacterial isolates showed different percentages of susceptibility to the tested antibiotics., Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2021.)

Assessing the potential impacts of different land management practices helps to identify and implement sustainable watershed management measures. This study aims to assess a change in soil erosion rate under different land management practices in the Gilgel Abay watershed of the upper Blue Nile basin, Ethiopia. The Revised Universal Soil Loss Equation (RUSLE) model that was adapted to the Ethiopian highlands context was employed to estimate the rate of soil erosion. The impact of land management practices on soil erosion was estimated for three scenarios, which were baseline, intensive cultivation, and extensive cultivation scenarios. At the baseline scenario, the mean annual soil erosion was estimated at ~32.8 t ha -1 yr -1 , which is equivalent to a loss of ~13.66 Mt yr -1 from the entire watershed. While the rate of soil erosion reduced to ~11.3 t ha -1 yr -1 during the implementation of intensive cultivation management practice, which reduced the total soil loss in the watershed by 65%. On the other hand, under the extensive cultivation scenario, the mean annual soil erosion rate increased to ~34.4 t ha -1 yr -1 . The findings suggest that implementing agricultural intensification management practices can significantly reduce soil erosion in the watershed., (© 2020 Published by Elsevier Ltd.)

Verbena officinalis L. has a folkloric repute for the management of digestive disorders, including diarrhea. However, the safety and efficacy of the plant material has not been scientifically validated yet. This study was, therefore, aimed to evaluate the overall antidiarrheal activity of the 80% methanol extracts of V officinalis in mice. The antidiarrheal activity of the 80% methanol extracts of the roots (R-80ME) and the leaves (L-80ME) of V officinalis was tested in castor oil-induced diarrhea in mice. R-80ME was further evaluated using charcoal meal and entero-pooling. In each test, group I and group II (controls) received 10 mL/kg distilled water and standard drug (5 mg/kg loperamide), respectively, whereas groups III, IV, and V (test groups) received 100, 200, and 400 mg/kg of the 80ME, respectively. The R-80ME at 200 mg/kg ( P < .01) and 400 mg/kg ( P < .001) significantly delayed the onset of diarrhea compared with negative control. Both R-80ME and L-80ME at 200 and 400 mg/kg significantly decreased the frequency of wet fecal outputs ( P < .01). Generally, 70.24% inhibition of the number of wet fecal output was recorded at R-80ME 400 mg/kg. Results from the charcoal meal test revealed that the R-80ME at 200 ( P < .01) and 400 mg/kg ( P < .001) produced a significant antimotility effect. In entero-pooling test, the R-80ME, at 200 and 400 mg/kg doses ( P < .01), showed a significant decline in both the volume and weight of intestinal contents. The maximum in vivo antidiarrheal index was determined to be 95.25 at dose of 400 mg/kg R-80ME. This study demonstrated that the 80ME, mainly the root extract, produced promising antidiarrheal activity and hence provides a scientific support for acclaimed traditional use of the plant material for treatment of diarrheal diseases.