10 results on '"Gao, Zi-Hou"'
Search Results
2. A large-scale fatal outbreak of Pasteurella multocida among wild rodents in southwestern China
- Author
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Du, Chun-Hong, Huang, Yong, Jiang, Jia-Fu, Gao, Zi-Hou, Jia, Na, Yang, Shan, Chen, Chao-Nian, Ma, Shun-Gao, Liang, Yu-Ying, Jiang, Bao-Gui, Sang, Wei-Hong, Wang, Peng, Liang, Yun, Zhang, Yun-Zhi, Zhou, Ji-Hua, Chen, Shui-Ping, Jongejan, Frans, Song, Zhi-Zhong, Tong, Yi-Gang, and Cao, Wu-Chun
- Published
- 2020
- Full Text
- View/download PDF
3. Zoonotic pathogens identified in rodents and shrews from four provinces, China, 2015–2022.
- Author
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Tian, Shen, Jiang, Bao-Gui, Liu, Wan-Shuang, Chen, Hao-Rong, Gao, Zi-Hou, Pu, En-Nian, Li, Yu-Qiong, Chen, Jin-Jin, Fang, Li-Qun, Wang, Guo-Lin, Du, Chun-Hong, and Wei, Yue-Hong
- Abstract
Rodents and shrews are major reservoirs of various pathogens that are related to zoonotic infectious diseases. The purpose of this study was to investigate co-infections of zoonotic pathogens in rodents and shrews trapped in four provinces of China. We sampled different rodent and shrew communities within and around human settlements in four provinces of China and characterised several important zoonotic viral, bacterial, and parasitic pathogens by PCR methods and phylogenetic analysis. A total of 864 rodents and shrews belonging to 24 and 13 species from RODENTIA and EULIPOTYPHLA orders were captured, respectively. For viral pathogens, two species of hantavirus (Hantaan orthohantavirus and Caobang orthohantavirus) were identified in 3.47% of rodents and shrews. The overall prevalence of Bartonella spp. Anaplasmataceae, Babesia spp. Leptospira spp. Spotted fever group Rickettsiae, Borrelia spp. and Coxiella burnetii were 31.25%, 8.91%, 4.17%, 3.94%, 3.59%, 3.47%, and 0.58%, respectively. Furthermore, the highest co-infection status of three pathogens was observed among Bartonella spp. Leptospira spp. and Anaplasmataceae with a co-infection rate of 0.46%. Our results suggested that species distribution and co-infections of zoonotic pathogens were prevalent in rodents and shrews, highlighting the necessity of active surveillance for zoonotic pathogens in wild mammals in wider regions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
4. High Diversity of Tick-associated Microbiota from Five Tick Species in Yunnan, China.
- Author
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Zhang, Jie, Ni, Xue-Bing, Chen, Zi-Yun, Zhang, Yun, Wei, Ran, Gong, Zheng-Da, Zhu, Dai-Yun, Cui, Xiao-Ming, Shao, Zong-Ti, Liu, Hong-Bo, Li, Yu-Qiong, Wang, Jian, Gao, Zi-Hou, Duan, Xing-De, Jiang, Hang, Jiang, Jia-Fu, Lam, Tommy Tsan-Yuk, Huang, En-Jiong, Jia, Na, and Du, Chun-Hong
- Subjects
RIBOSOMAL RNA ,PATHOGENIC microorganisms ,RICKETTSIA ,POLYMERASE chain reaction - Abstract
Objective: Ticks are obligate blood-sucking vectors for multiple zoonotic diseases. In this study, tick samples were collected from Yunnan Province, China, which is well-known as the "Global Biodiversity Hotspot" in the world. This study aimed to clarify the microbial populations, including pathogens, associated with ticks and to identify the diversity of tick-borne microbiota in this region. Methods: The 16S rRNA full-length sequencing from pooled tick DNA samples and PCR amplification of pathogenic genera from individual samples were performed to understand tick-associated microbiota in this region. Results: A total of 191 adult ticks of 5 tick species were included and revealed 11 phyla and 126 genera bacteria, including pathogenic Anaplasma, Ehrlichia, Candidatus Neoehrlichia, Rickettsia, Borrelia, and Babesia. Further identification suggested that Rickettsia sp. YN01 was a variant strain of Rickettsia spp. IG-1, but Rickettsia sp. YN02 and Rickettsia sp. YN03, were potentially two new SFGR species. Conclusions: This study revealed the complexity of ecological interactions between host and microbe and provided insight for the biological control of ticks. A high microbial diversity in ticks from Yunnan was identified, and more investigation should be undertaken to elucidate the pathogenicity in the area. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
5. Community structure and distribution pattern of small mammals in agricultural area of Yun- nan Province, China.
- Author
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CHEN Xing, LIU Zheng-xiang, DU Chun-hong, HONG Mei, GONG Zheng-da, SHAO Zong-ti, DUAN Xing-de, and GAO Zi-hou
- Abstract
To understand the characteristics of community structure and spatial distribution of small mammals in agricultural area of Yunnan Province, a systematic investigation was carried out in 104 quadrats of 25 regions in Yunnan Province from August 2010 to April 2018 by rat trap night method. The spatial variation of community characteristics along environmental gradients was analyzed by community ecological indicators. The results showed that a total of 3240 small mammals were captured and cold be classified into 42 species in 21 genera, 9 families, and 4 orders. The largest number of small mammal was rodents, dominated by Apodemus chevrieri and Rattus tanezumi. The 25 regions were clustered into three classes. The altitudinal distribution of small mammals was similar to the latitudinal distribution in agricultural areas. The number of species was relatively less in the low latitude and altitude range, with Rattus spp. and Mus spp. as the dominant species. In the high latitude and altitude region, the dominant species changed into Apodemus, Niviventer and Eothenomys. With the increases of altitude, the diversity index showed unimodal distribution, with the highest species diversity occurred in the mid-altitude area. The diversity index of small mammal showed the "V" type pattern in longitude, being the highest in the 98°-99° E gra-dient zone. At the latitude level, it showed an overall upward trend from south to north. Results from the GAM analysis showed that the degree of influence on the small animals in the agricultural area was in order of longitude, altitude and latitude. The similarity analysis in the composition of small mammals showed that the moderate similarity occurred in the adjacent gradient zone, and the highest similarity occurred in middle altitude zone, middle latitude zone, and low longitude zone. The farther the distance between different gradient zones, the lower the similarity of community structure. There was high spatial heterogeneity in different dimensions of small mammals' community structure in Yunnan Province. The geographical distribution trend of species diversity showed different distribution patterns across environmental gradients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
6. Investigation on Ehrlichia Infection in Small Mammals and Ticks from Tengchong, Yunnan Province, Southern China.
- Author
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Du, Chun-Hong, Liu, Hong-Bo, Wei, Ran, Jongejan, Frans, Gao, Zi-Hou, Shao, Zong-Ti, Duan, Xing-De, Jiang, Bao-Gui, Liu, Yun-Xi, Jiang, Jia-Fu, Jia, Na, and Cao, Wu-Chun
- Subjects
EHRLICHIOSIS ,MAMMAL diseases - Abstract
Background: Rare investigation on tick-borne pathogens was carried out in Yunnan, China. In this study, we did a survey on Ehrlichia infection in small mammals and ticks. A total of 40 small mammals and 49 ticks were collected from Tengchong, Yunnan province. PCR targeting 16S ribosomal RNA (rRNA), citrate synthase, GroEL heat-shock protein operon, and major outer membrane protein genes was performed and positive amplicons were sequenced. Results: The 40 small mammals were identified as 10 species, 2 (5.0%) of which were infected with Ehrlichia, 4 (10.0%) were infected with Anaplasma phagocytophilum and another 2 (5.0%) were infected with Candidatus Neoehrlichia mikurensis. Six (12.2%) ticks were positive for Ehrlichia and another two (4.1%) were infected with A. phagocytophilum. Neither small mammals nor ticks had coinfection. The detected Ehrlichia was named as Ehrlichia sp. YN04, which was in the same clade of Ehrlichia sp. 360 by phylogenetic analysis. The sequences of the pathogen recovered from small mammals and ticks were identical with each other. Conclusion: The study reports one Ehrlichia species first detected from small mammals and ticks in mainland China. As Yunnan is a famous "Global Biodiversity Hotspot" in the world, we may expect much more tick-borne infectious pathogens existing and declare more public health attention in this region. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
7. Wide Distribution and Genetic Diversity of Babesia microti in Small Mammals from Yunnan Province, Southwestern China.
- Author
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Gao, Zi-Hou, Huang, Tao-Hua, Jiang, Bao-Gui, Jia, Na, Liu, Zheng-Xiang, Shao, Zong-Ti, Jiang, Rui-Ruo, Liu, Hong-Bo, Wei, Ran, Li, Yu-Qiong, Yao, Hong-Wu, Fricken, Michael von, Jiang, Jia-Fu, Du, Chun-Hong, and Cao, Wu-Chun
- Subjects
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BABESIA , *RIBOSOMAL RNA , *MAMMALS , *DISEASE prevalence , *SYMPTOMS - Abstract
Background: Babesia, usually found in wild and domestic mammals worldwide, have recently been responsible for emerging malaria-like zoonosis in infected patients. Human B. microti infection has been identified in China, primarily in the Southwest along the Myanmar border but little direct surveillance of B. microti infection in rodents has been carried out here (Yunnan province). In this region, a diverse topographic range combined with tropical moisture sustains a high biodiversity of small mammals, which might play important role on Babesia transmission. Methods: Small mammals were captured in 141 sample locations from 18 counties located Yunnan Province, and screened for B. microti-like parasites infection by a nested PCR to target 18S rRNA gene of Babesia, plus directly sequencing for positive samples. Univariate and multivariate forward stepwise logistic regression analysis was used to access the association between infections and some related risk factors. Results: Infection with Babesia microti was confirmed in 2.4% (53/ 2204) of small mammals. Significant differences in prevalence rates of B. microti were observed based on variations in forest, agricultural, and residential landscapes. Furthermore, adult small mammals had higher prevalence rates than younger, pubertal mammals. The near full-length 18S rRNA gene revealed that there were two types of B. microti, Kobe and Otsu, which demonstrate the genetic diversity and regional distribution. Conclusions: There exists a wide distribution and genetic diversity of endemic B. microti in Southwestern China, warranting further investigations and monitoring of clinical disease in individuals presenting with Babesia like symptoms in these areas. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
8. Individual bat viromes reveal the co-infection, spillover and emergence risk of potential zoonotic viruses.
- Author
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Wang J, Pan YF, Yang LF, Yang WH, Luo CM, Wang J, Kuang GP, Wu WC, Gou QY, Xin GY, Li B, Luo HL, Chen YQ, Shu YL, Guo D, Gao ZH, Liang G, Li J, Holmes EC, Feng Y, and Shi M
- Abstract
Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within bats at the level of individual animals, and hence the frequency of virus co-infection and inter-species transmission. Using an unbiased meta-transcriptomics approach we characterised the mammalian associated viruses present in 149 individual bats sampled from Yunnan province, China. This revealed a high frequency of virus co-infection and species spillover among the animals studied, with 12 viruses shared among different bat species, which in turn facilitates virus recombination and reassortment. Of note, we identified five viral species that are likely to be pathogenic to humans or livestock, including a novel recombinant SARS-like coronavirus that is closely related to both SARS-CoV-2 and SARS-CoV, with only five amino acid differences between its receptor-binding domain sequence and that of the earliest sequences of SARS-CoV-2. Functional analysis predicts that this recombinant coronavirus can utilize the human ACE2 receptor such that it is likely to be of high zoonotic risk. Our study highlights the common occurrence of inter-species transmission and co-infection of bat viruses, as well as their implications for virus emergence.
- Published
- 2022
- Full Text
- View/download PDF
9. [Community structure and distribution pattern of small mammals in agricultural area of Yunnan Province, China.]
- Author
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Chen X, Liu ZX, DU CH, Hong M, Gong ZD, Shao ZT, Duan X, and Gao ZH
- Subjects
- Agriculture, Altitude, Animals, China, Murinae, Biodiversity, Mammals
- Abstract
To understand the characteristics of community structure and spatial distribution of small mammals in agricultural area of Yunnan Province, a systematic investigation was carried out in 104 quadrats of 25 regions in Yunnan Province from August 2010 to April 2018 by rat trap night method. The spatial variation of community characteristics along environmental gradients was analyzed by community ecological indicators. The results showed that a total of 3240 small mammals were captured and cold be classified into 42 species in 21 genera, 9 families, and 4 orders. The largest number of small mammal was rodents, dominated by Apodemus chevrieri and Rattus tanezumi. The 25 regions were clustered into three classes. The altitudinal distribution of small mammals was similar to the latitudinal distribution in agricultural areas. The number of species was relatively less in the low latitude and altitude range, with Rattus spp. and Mus spp. as the dominant species. In the high latitude and altitude region, the dominant species changed into Apodemus, Niviventer and Eothenomys. With the increases of altitude, the diversity index showed unimodal distribution, with the highe-st species diversity occurred in the mid-altitude area. The diversity index of small mammal showed the "V" type pattern in longitude, being the highest in the 98°-99° E gra-dient zone. At the latitude level, it showed an overall upward trend from south to north. Results from the GAM analysis showed that the degree of influence on the small animals in the agricultural area was in order of longitude, altitude and latitude. The similarity analysis in the composition of small mammals showed that the moderate similarity occurred in the adjacent gradient zone, and the highest similarity occurred in middle altitude zone, middle latitude zone, and low longitude zone. The farther the distance between different gradient zones, the lower the similarity of community structure. There was high spatial heterogeneity in different dimensions of small mammals' community structure in Yunnan Province. The geographical distribution trend of species diversity showed different distribution patterns across environmental gradients.
- Published
- 2019
- Full Text
- View/download PDF
10. Investigation on Ehrlichia Infection in Small Mammals and Ticks from Tengchong, Yunnan Province, Southern China.
- Author
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Du CH, Liu HB, Wei R, Jongejan F, Gao ZH, Shao ZT, Duan XD, Jiang BG, Liu YX, Jiang JF, Jia N, and Cao WC
- Subjects
- Animals, China epidemiology, DNA, Bacterial genetics, Ehrlichiosis epidemiology, Ehrlichiosis microbiology, Phylogeny, Ehrlichia isolation & purification, Ehrlichiosis veterinary, Mammals microbiology, Ticks microbiology
- Abstract
Background: Rare investigation on tick-borne pathogens was carried out in Yunnan, China. In this study, we did a survey on Ehrlichia infection in small mammals and ticks. A total of 40 small mammals and 49 ticks were collected from Tengchong, Yunnan province. PCR targeting 16S ribosomal RNA (rRNA), citrate synthase, GroEL heat-shock protein operon, and major outer membrane protein genes was performed and positive amplicons were sequenced., Results: The 40 small mammals were identified as 10 species, 2 (5.0%) of which were infected with Ehrlichia, 4 (10.0%) were infected with Anaplasma phagocytophilum and another 2 (5.0%) were infected with Candidatus Neoehrlichia mikurensis. Six (12.2%) ticks were positive for Ehrlichia and another two (4.1%) were infected with A. phagocytophilum. Neither small mammals nor ticks had coinfection. The detected Ehrlichia was named as Ehrlichia sp. YN04, which was in the same clade of Ehrlichia sp. 360 by phylogenetic analysis. The sequences of the pathogen recovered from small mammals and ticks were identical with each other., Conclusion: The study reports one Ehrlichia species first detected from small mammals and ticks in mainland China. As Yunnan is a famous "Global Biodiversity Hotspot" in the world, we may expect much more tick-borne infectious pathogens existing and declare more public health attention in this region.
- Published
- 2018
- Full Text
- View/download PDF
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