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Myocardial infarction (MI) is a complicated pathology triggered by numerous environmental and genetic factors. Understanding the effect of epigenetic regulation mechanisms on the cardiovascular disease would advance the field and promote prophylactic methods targeting epigenetic mechanisms. Genetic screening guides individualised MI therapies and surveillance. The present review reported the latest development on the epigenetic regulation of MI in terms of DNA methylation, histone modifications, and microRNA-dependent MI mechanisms and the novel therapies based on epigenetics. [ABSTRACT FROM AUTHOR]

Nowadays, dual-active-bridge (DAB) DC/DC converter is widely used for its high power density and flexible operation mode. However, complex control variables and high reflux power are the main disadvantages of the system, which have become its development bottleneck. In view of this, this paper presents an in-depth analysis of the impacts of three phase-shifting degrees of freedom on the transmission power and effective values of the inductive current based on the triple-phase-shift (TPS) control strategy by deducing the relationship equations between the three degrees of freedom and the other two variables in the TPS control system. Based on the equations, the method of using the multi-objective particle swarm optimization (MOPSO) algorithm to optimize three phase shift angles is proposed, which cannot only improve the convergence speed of the optimal phase shift angle but also be ideal for solving nonlinear problems. The experimental results show that this method can improve the transmission power and reduce the effective value of inductive current. [ABSTRACT FROM AUTHOR]

Traditional dual active bridge converters use transformer leakage inductance instead of energy storage inductors for magnetic integration, but this method cannot accurately control the leakage inductance. A phase shift control dual active bridge converter base on integrated magnetics is proposed, in which one transformer and one inductor are integrated in an EE core. The size of the inductance can be accurately controlled. The transformer and the inductor are decoupled and integrated so that the two operating states do not affect each other. The weight and volume of the magnetic elements are reduced accordingly. The finite element analysis and magnetic circuit simulation of the integrated magnetics are carried out. Finally, the integrated magnetics are designed and applied to the 600W prototype to realize bidirectional power transmission and a weight reduction is about 36.24% and a volume reduction is about 35.84%. The correctness of the design is verified by experimental results. [ABSTRACT FROM AUTHOR]

The power supply discrepancy between advanced CMOS technology and legacy optical module leads to poor power efficiency or extra DC–DC component. A new stacked multi-channel receiver architecture and its synergetic power supply scheme for power-efficient optical links are proposed to solve the problem. Consequently, power reduction can be achieved thanks to the full utilization of available power supply headroom and the reuse of supply current. As a proof of concept, a stacked $2 \times 10$ Gb/s optical receiver with a synergetic-integrated linear multi-output regulator is implemented in 0.18- $\mu \text{m}$ CMOS technology, demonstrating the feasibility of the proposed architecture. State-of-the-art receiver performance and power efficiency are achieved. [ABSTRACT FROM AUTHOR]

Battery management systems (BMS) are widely used in energy storage systems and electric vehicles. The precise estimation of state-of-charge is a key factor affecting the performance of BMS. For the difficulty of calculating the charge status of storage lithium battery (e.g. poor estimation and reliability), this study presents the way of unscented Kalman particle filter (UPF) based on the online recursive least square method matched by dual polarisation battery model. The results show that, compared to the extended Kalman filter (EKF), extended Kalman particle filter (EKPF) and the unscented Kalman filter, the estimate accuracy was improved by 50.9, 33.4 and 19.6%, respectively. The online parameter identification assisted by UPF shows stronger inhibitory effect and the convergence stability. Besides, in comparison to the offline parameter identification with UPF, the estimated accuracy of 27.59% was improved by using the online parameter identification. [ABSTRACT FROM AUTHOR]

Short-circuit faults are inevitable in split-winding transformers with stabilizing windings, and the resulting transient electromagnetic force may cause detrimental damages to the equipment. This paper focuses on a comprehensive analysis of the characteristics of the split-winding transformer with stabilizing windings under different short-circuit faults. In this regard, a FEM based on a field-circuit coupled approach is proposed. Also, a SFFZ10-88000-kVA split-winding transformer with stabilizing windings is used as a prototype to investigate its transient performances with both full-crossing and half-crossing conditions under different short-circuit faults. The symmetrical component method is presented to compute short-circuit currents to compare with the simulation ones, and a prototype test model is established to verify the correctness of the proposed method. The results reveal that the axial forces exerted on the winding in half-crossing short-circuit faults are generally larger than those in full-crossing short-circuit faults. Moreover, there is a considerable short-circuit force in the stabilizing winding in cases of a single-phase earthed fault and a two-phase earthed fault and there is no current in the stabilizing winding under other short-circuit fault cases. The numerical modeling approach dealt with in this paper is expected to be useful in the design of the split-winding transformer with stabilizing windings. [ABSTRACT FROM AUTHOR]

Background: Endovascular treatment (EVT) is advocated for acute ischaemic stroke with large-vessel occlusion (LVO), but perioperative periods are challenging. This study investigated the relationship between post-EVT short-term blood pressure variability (BPV) and early outcomes in LVO patients.Methods: We retrospectively reviewed 72 LVO patients undergoing EVT between June 2015 and June 2018. Hourly systolic and diastolic blood pressures (SBP and DBP, respectively) were recorded in the first 24 h post-EVT. BPV were evaluated as standard deviation (SD), coefficient of variation (CV), and successive variation (SV) separately for SBP and DBP. Functional independence at 3 months was defined as a modified Rankin Scale (mRS) score of 0-2.Results: For 58.3% patients with favorable outcomes, the median National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT scores on admission were 14 and 8, respectively. The maximum SBP ([154.3 ± 16.8] vs. [163.5 ± 15.6], P = 0.02), systolic CV ([8. 8% ± 2.0%] vs. [11.0% ± 1.8], P < 0.001), SV ([11.4 ± 2.3] vs. [14.6 ± 2.0], P < 0.001), and SD ([10.5 ± 2.4] vs. [13.8 ± 3.9], P < 0.001) were lower in patients with favorable outcomes. On multivariable logistic regression analysis, systolic SV (OR: 4.273, 95% CI: 1.030 to 17.727, P = 0.045) independently predicted unfavorable prognosis. The area under the curve was 0.868 (95% CI: 0.781 to 0.955, P < 0.001), and sensitivity and specificity were 93.3% and 73.8%, respectively, showing excellent predictive value for 3-month poor-outcomes.Conclusions: Decreased systolic SV following intra-arterial therapies result in favorable outcomes at 3 months. Systolic SV may be a novel predictor of functional prognosis in LVO patients. [ABSTRACT FROM AUTHOR]

Objective. Ischemic preconditioning (IPC) has gradually been promoted in clinical practice to lower the risk of cardiovascular surgery and postoperative complications. We investigated the role of IPC on vascular endothelial function and the relationship between IPC, flow-mediated dilation (FMD), and brachial artery diameter (BAD). Methods. Systematic searches were conducted in PubMed, Medline, Cochrane Library, Embase, and Scopus databases from their inception to March 20, 2020. This research included randomized controlled trials (RCTs) with adults, and the values of FMD and BAD were considered as the primary outcomes. Ten studies comprising 292 participants were included in the meta-analysis. Results. Regarding FMD, we observed beneficial effects of IPC on endothelial function (standardized mean difference (SMD): 1.82; 95% confidence interval (CI): 0.64, 3.01; p < 0.001 ; I2 = 89.9%). However, the available evidence did not indicate that IPC affected BAD (SMD: 0.08; 95% CI: −0.03, 0.18; p > 0.05 ; I2 = 76.5%). Conclusions. Our meta-analysis indicated a significant effect of IPC on the endothelial function of the blood vessels, affecting FMD but not BAD. [ABSTRACT FROM AUTHOR]

In this review, we investigated the potential mechanism of Total Salvianolic Acid Injection (TSI) in protecting against myocardial ischemia reperfusion injury (MI/RI). To achieve this, we predicted the component targets of TSI using Pharmmapper and identified the disease targets of MI/RI through GeneCards, DisGenNET, and OMIM databases. We constructed protein-protein interaction networks by analyzing the overlapping targets and performed functional enrichment analyses using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Our analysis yielded 90 targets, which were implicated in the potential therapeutic effects of TSI on MI/RI. Seven critical signaling pathways significantly contributed to TSI's protective effects, namely, PI3K signaling, JAK-STAT signaling, Calcium signaling, HIF-1 signaling, Nuclear receptor signaling, Cell Cycle, and Apoptosis. Subsequently, we conducted a comprehensive literature review of these seven key signaling pathways to gain further insights into their role in the TSI-mediated treatment of MI/RI. By establishing these connections, our study lays a solid foundation for future research endeavours to elucidate the molecular mechanisms through which TSI exerts its beneficial effects on MI/RI., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Li, Gu, Liu, Zhang, Sun, Gao, Wang and Zhang.)