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Your search keyword '"GRECO, FRANCESCA"' showing total 491 results
Start Over Author "GRECO, FRANCESCA" Publication Type Academic Journals
491 results on '"GRECO, FRANCESCA"'

1. Educating and Training in Research Integrity (RI): A Study on the Perceptions and Experiences of Early Career Researchers Attending an Institutional RI Course

Author

Greco Francesca, Silvia Ceruti, Stefano Martini, Mario Picozzi, Marco Cosentino, and Franca Marino

Abstract

Research integrity (RI) is defined as adherence to ethical principles, deontological duties, and professional standards necessary for responsible conduct of scientific research. Early training on RI, especially for early-career researchers, could be useful to help develop good standards of conduct and prevent research misconduct (RM).The aim of this study is to assess the effectiveness of a training course on RI, by mapping the attitudes of early-career researchers on this topic through a questionnaire built upon the revised version of the Scientific Misconduct Questionnaire and administered to all participants at the beginning and at the end of the course. Results show that after the course, participants reporting a high understanding of the rules and procedures related to RM significantly increased (pre-course: 38.5%, post-course: 61.5%), together with the percentage of those reporting a lack of awareness on the extent of misconduct (pre-course: 46.2%, post-course: 69.2%), and of those who believe that the lack of research ethics consultation services strongly affects RM (pre-course: 15.4%, post-course: 61.5%). Early-career researchers agree on the importance to share with peers and superiors any ethical concern that may arise in research, and to create a work environment that fosters RI awareness. As a whole, results suggest the effectiveness of the course. Institutions should introduce RI training for early-career researchers, together with research methodology, integrity and ethics consultation services to support them. Senior scientists should promote RI into their research practices, and should stimulate engagement in peer-to-peer dialogue to develop good practices based on RI principles.

Published
2024
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2. COL1A1::PDGFB fusion-associated uterine fibrosarcoma: A case report and review of the literature.

Author

Rota, Simone, Franza, Andrea, Fabbroni, Chiara, Paolini, Biagio, Greco, Francesca, Alessi, Alessandra, Padovano, Barbara, Sanfilippo, Roberta, and Casali, Paolo

Subjects
COL1A1::PDGFB, Imatinib, fibrosarcoma, soft tissue sarcomas, translocation t(17, 22)(q22, q13), uterus, Female, Humans, Adult, Proto-Oncogene Proteins c-sis, Imatinib Mesylate, Dermatofibrosarcoma, In Situ Hybridization, Fluorescence, Leiomyosarcoma, Skin Neoplasms, Neoplasm Recurrence, Local, Fibrosarcoma, Soft Tissue Neoplasms, Translocation, Genetic, Uterus
Abstract

BACKGROUND: Mesenchymal neoplasms of the uterus encompass a diverse group of tumors, with varying characteristics and origins, collectively accounting for 8% of uterine malignancies. The most common variants include uterine leiomyosarcoma, low-grade and high-grade endometrial stromal sarcoma, adenosarcoma, and undifferentiated sarcoma. Clinical presentation is often nonspecific and can lead to delayed diagnosis. Uterine sarcomas are generally aggressive, resulting in poorer prognosis compared to carcinomas. Recent advances in molecular techniques, such as next-generation sequencing (NGS), have led to the identification of new subtypes of uterine sarcomas, including COL1A1::PDGFB fusion-associated fibrosarcoma, which has a specific chromosomal translocation t(17;22)(q22;q13). Imatinib, a tyrosine kinase inhibitor (TKI), is an effective treatment for dermatofibrosarcoma protuberans (DFSP), marked by this translocation. CASE: We present the case of a 42-year-old woman diagnosed with COL1A1::PDGFB fusion-associated uterine fibrosarcoma. The patient underwent total hysterectomy and excision of the tumor, initially misdiagnosed as a low-grade leiomyosarcoma. Subsequent histological examination, immunohistochemistry, and fluorescence in situ hybridization (FISH) confirmed the diagnosis. After 10 months, disease recurrence was detected, and Imatinib therapy was initiated at a dose of 400 mg daily. An allergic reaction led to a temporary discontinuation, but upon resumption with appropriate medication, a positive radiological response was observed. The patient achieved a complete remission after 2 years and is still on Imatinib treatment. CONCLUSIONS: COL1A1::PDGFB fusion-associated uterine fibrosarcoma is an extremely rare mesenchymal neoplasm. In a case we present herein, we treated a patient with imatinib as first-line medical therapy. The patient is currently in complete remission after 37 months from treatment start. To the best of our knowledge, this represents a unique observation. We also provide a detailed literature review of the published cases so far. Prospective case series are needed to further understand the natural history of these tumors and optimize treatment strategies.

Published
2024

3. Human Campylobacter spp. infections in Italy

Author

Zerbato, Verena, Di Bella, Stefano, Pol, Riccardo, Luzzati, Roberto, Sanson, Gianfranco, Ambretti, Simone, Andreoni, Stefano, Aschbacher, Richard, Bernardo, Mariano, Bielli, Alessandra, Brigante, Gioconda, Busetti, Marina, Camarlinghi, Giulio, Carcione, Davide, Carducci, Antonella, Clementi, Nicola, Carretto, Edoardo, Chilleri, Chiara, Codda, Giulia, Consonni, Alessandra, Costantino, Venera, Cortazzo, Venere, Di Santolo, Manuela, Dodaro, Saveria, Fiori, Barbara, García-Fernández, Aurora, Foschi, Claudio, Gobbato, Elisa, Greco, Francesca, La Ragione, Roberto Marcello, Mancini, Nicasio, Maraolo, Alberto Enrico, Marchese, Anna, Marcuccio, Daniela, Marrollo, Roberta, Mauri, Carola, Mazzariol, Annarita, Morroni, Gianluca, Mosca, Adriana, Nigrisoli, Giacomo, Pagani, Elisabetta, Parisio, Eva Maria, Pollini, Simona, Sarti, Mario, Sorrentino, Annarita, Trotta, Domenico, Villa, Laura, Vismara, Chiara, and Principe, Luigi

Published
2024
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7. Sunitinib for the treatment of patients with advanced pheochromocytomas or paragangliomas: The phase 2 non-randomized SUTNET clinical trial

Author

Nasca, Vincenzo, Prinzi, Natalie, Coppa, Jorgelina, Prisciandaro, Michele, Oldani, Simone, Ghelardi, Filippo, Conca, Elena, Capone, Iolanda, Busico, Adele, Perrone, Federica, Tamborini, Elena, Sabella, Giovanna, Greco, Giorgio, Greco, Francesca Gabriella, Tafuto, Salvatore, Procopio, Giuseppe, Morano, Federica, Niger, Monica, Maccauro, Marco, Milione, Massimo, de Braud, Filippo, Pietrantonio, Filippo, and Pusceddu, Sara

Published
2024
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20. STYLE (NCT03449173): A Phase 2 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines

Author

Proto, Claudia, Manglaviti, Sara, Lo Russo, Giuseppe, Musca, Marco, Galli, Giulia, Imbimbo, Martina, Perrino, Matteo, Cordua, Nadia, Rulli, Eliana, Ballatore, Zelmira, Dal Maso, Alessandro, Chella, Antonio, Sbrana, Andrea, Prelaj, Arsela, Ferrara, Roberto, Occhipinti, Mario, Brambilla, Marta, De Toma, Alessandro, Mazzeo, Laura, Beninato, Teresa, Signorelli, Diego, Massa, Giacomo, Greco, Francesca Gabriella, Calareso, Giuseppina, Miliziano, Daniela, Di Mauro, Rosa Maria, Mella, Giulia, Lucarelli, Alessandra, Paggio, Angela, Galli, Francesca, Torri, Valter, de Braud, Filippo Guglielmo Maria, Pasello, Giulia, Petrini, Iacopo, Berardi, Rossana, Ganzinelli, Monica, Garassino, Marina Chiara, and Zucali, Paolo Andrea

Published
2023
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26. Anaerobic bloodstream infections in Italy (ITANAEROBY): A 5-year retrospective nationwide survey

Author

Di Bella, Stefano, Antonello, Roberta Maria, Sanson, Gianfranco, Maraolo, Alberto Enrico, Giacobbe, Daniele Roberto, Sepulcri, Chiara, Ambretti, Simone, Aschbacher, Richard, Bartolini, Laura, Bernardo, Mariano, Bielli, Alessandra, Busetti, Marina, Carcione, Davide, Camarlinghi, Giulio, Carretto, Edoardo, Cassetti, Tiziana, Chilleri, Chiara, De Rosa, Francesco Giuseppe, Dodaro, Saveria, Gargiulo, Raffaele, Greco, Francesca, Knezevich, Anna, Intra, Jari, Lupia, Tommaso, Concialdi, Erika, Bianco, Gabriele, Luzzaro, Francesco, Mauri, Carola, Morroni, Gianluca, Mosca, Adriana, Pagani, Elisabetta, Parisio, Eva Maria, Ucciferri, Claudio, Vismara, Chiara, Luzzati, Roberto, and Principe, Luigi

Published
2022
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29. Influence of living settings on physical activity levels and volition in exercise in male and female university students.

Author

Quinzi, Federico, Cosco, Loretta Francesca, Greco, Francesca, Folino, Katia, Cerulli, Claudia, Oranges, Francesco Pio, Facchin, Alessio, Tarsitano, Maria Grazia, and Emerenziani, Gian Pietro

Subjects
MALE college students, FAILURE (Psychology), SELF-confidence, COLLEGE students
Abstract

This study explored the influence of living settings on physical activity (PA) levels and volition in exercise and their correlation, considering sex differences. Five hundred and sixty-six university students (261 rural and 305 urban) from Calabria region (Italy) attending universities courses filled an online survey where Global Physical Activity Questionnaire and Volition in Exercise Questionnaire were administered. Rural females (RF) showed lower PA levels and self-confidence than rural males (RM) (p<0.01). Postponing training and unrelated thoughts were higher in RF than RM (p<0.01 and p<0.05 respectively). PA levels, self-confidence and coping with failure were lower in urban females (UF) than urban males (UM) (p<0.01), Postponing training and unrelated thoughts were higher in UF than UM (p<0.01 and p<0.05). In RF and UF, PA levels positively correlated with self-confidence (Rho = 0.397) and coping with failure (Rho = 0.330), whereas negatively correlated with postponing training (Rho = -0.487) and unrelated thoughts (Rho = -0.283). In RM and UM, PA levels positively correlated with self-confidence (Rho = 0.270) and coping with failure (Rho = 0.258), whereas it negatively correlated with postponing training (Rho = -0.285). PA levels positively correlated with reasons (Rho = 0.260) only in UM. We showed for the first time the relationship between PA and volition factors considering the living setting in university students. Sex differences were observed in some volition facilitators and PA levels independently by the living context. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Study of metabolism and potential toxicity of nine synthetic opioid analogs using the zebrafish larvae model.

Author

Murari, Matilde, Pesavento, Sara, Greco, Francesca, Vettori, Andrea, Tagliaro, Franco, and Gottardo, Rossella

Abstract

The use of novel psychoactive substances (NPSs) has dramatically increased worldwide, and among them, synthetic opioids are one of the fastest growing groups, where cinnamylpiperazines and 2‐benzylbenzimidazoles represent two of the most relevant subclasses. However, the data on their toxicity and metabolism are still limited. The aim of the present study was to evaluate the toxicity and metabolic pathways of some compounds belonging to these families, namely, AP‐237, 2‐methyl AP‐237, isotonitazene, flunitazene, etodesnitazene, metonitazene, metodesnitazene, N‐pyrrolidino etonitazene, and butonitazene. The study was performed using a zebrafish early life stages model. In fact, zebrafish (Danio rerio) embryos and larvae have recently been recognized as a suitable animal model in alternative to mammals, because they require less time and resources and do not need complex procedures for ethics approval. The cellular toxicity after a single administration was assessed at the fourth day post‐fertilization with acridine orange staining. Possible morphological defects were evaluated with a light microscope after 24 h of exposure to 1 μmol/L concentration of each drug. Subsequently, the larvae were euthanized and underwent analysis of drug metabolites using UPLC coupled to an Orbitrap high‐resolution mass spectrometer. High rates of morphological defects, as well as of cellular death, were detected, but no significant difference in mortality between treatment and control groups was observed. In addition, several metabolites, mainly produced through monohydroxylation, N‐dealkylation, and O‐dealkylation, were identified in the larvae extracts. [ABSTRACT FROM AUTHOR]

Published
2024
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41. The Effects of Online Home-Based Pilates Combined with Diet on Body Composition in Women Affected by Obesity: A Preliminary Study.

Author

Greco, Francesca, Tarsitano, Maria Grazia, Cosco, Loretta Francesca, Quinzi, Federico, Folino, Katia, Spadafora, Marco, Afzal, Moomna, Segura-Garcia, Cristina, Maurotti, Samantha, Pujia, Roberta, Pujia, Arturo, Buono, Pasqualina, and Emerenziani, Gian Pietro

Abstract

Diet and exercise intervention are the first strategies to counteract obesity. An online home-based exercise program may be a feasible approach in an obese population. Therefore, this study aimed to investigate the effects of twelve weeks of online Pilates plus diet on body composition in individuals affected by obesity. Thirty-five females were randomly assigned to a home-based Pilates group (PG, n = 18) or a group without intervention (control group, CG, n = 17). All participants followed a Mediterranean diet. The PG followed a twelve-week online Pilates Matwork program (three times/week; 180 min/week), while the CG was not involved in any structured physical exercise program. Body composition and handgrip strength were evaluated at baseline (T0) and after the intervention (T1). A significant group × time interaction (p < 0.05) was found for the fat mass percentage (pFM). Specifically, the pFM was significantly lower at T1 than at T0 in the PG. Significant group × time interactions for fat-free mass (p < 0.05), appendicular skeletal muscle mass (p < 0.05), and skeletal muscle mass (p < 0.01) were found. All these variables were significantly higher at T1 than at T0 in the PG (p < 0.05). Home-based Pilates combined with diet intervention may represent an effective strategy to improve body composition in terms of fat mass reduction and muscle mass gain in adults affected by obesity. [ABSTRACT FROM AUTHOR]

Published
2024
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