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Abstract Around 1526, Emperor Charles V decided to build a new Renaissance palace in addition to the Nasrid palaces in the Alhambra of Granada, a monumental site currently included in the United Nations Educational, Scientific and Cultural Organisation (UNESCO) World Heritage List. In that period, a large floor plan, which is preserved today at the Library of the Royal Palace of Madrid, was drawn to represent the building and its surroundings. Although this anonymous drawing has attracted considerable historiographic interest, a study of the graphical aspects analysed here, namely, paper assemblage, drawing technique, representation system, metrology, graphical scale, dimensioning, and labelling, is lacking. To accomplish this analysis, the original document was carefully examined and digitalised with high definition. This process allowed a comprehensive graphic analysis, utilising other drawings from the same period as a comparative reference and studying for the first time the major characteristics of one of the most relevant architectural drawings of the 16th century.

Abstract Ratios of glycerol dialkyl glycerol tetraethers (GDGT), which are membrane lipids of bacteria and archaea, are at the base of several paleoenvironmental proxies. They are frequently applied to soils as well as lake‐ and marine sediments to generate records of past temperature and soil pH. To derive meaningful environmental information from these reconstructions, high analytical reproducibility is required. Based on submitted results by 39 laboratories from across the world, which employ a diverse range of analytical and quantification methods, we explored the reproducibility of brGDGT‐based proxies (MBT′5ME, IR, and #ringstetra) measured on four soil samples and four soil lipid extracts. Correct identification and integration of 5‐ and 6‐methyl brGDGTs is a prerequisite for the robust calculation of proxy values, but this can be challenging as indicated by the large inter‐interlaboratory variation. The exclusion of statistical outliers improves the reproducibility, where the remaining uncertainty translates into a temperature offset from median proxy values of 0.3–0.9°C and a pH offset of 0.05–0.3. There is no apparent systematic impact of the extraction method and sample preparation steps on the brGDGT ratios. Although reported GDGT concentrations are generally consistent within laboratories, they vary greatly between laboratories. This large variability in brGDGT quantification may relate to variations in ionization efficiency or specific mass spectrometer settings possibly impacting the response of brGDGTs masses relative to that of the internal standard used. While ratio values of GDGT are generally comparable, quantities can currently not be compared between laboratories.

In the present article we analyse the impact of problem-based learning (PBL) on learning and perceptions in first-year students undertaking Engineering in Computer Sciences. The module designed took a number of advanced theories of PBL and its application within the Engineering profession. Mixed methods were used to enable data from qualitative and quantitative instruments to be obtained. A quasi-experimental design was specified, employing non-probabilistic sampling, with a control (N=40) and experimental group (N=39). In comparing PBL with traditional methods, the results reveal statistically significant differences in aspects such as academic performance. Teamwork, oral communication, written communication and students' perceptions of the learning experience were also all favoured. Nonetheless, lack of adequate team dynamics in previous learning experiences and reluctance to change traditional teaching approaches, could compromise the viability of that proposed.

BackgroundUncontrolled hypertension is a common problem worldwide, despite the availability of many effective antihypertensive drugs and lifestyle interventions. We assessed the efficacy of a multi-component intervention in individuals with uncontrolled hypertension in a primary care setting.MethodsThis study was a randomized, multicenter, parallel, two-arm, single-blind controlled trial performed in primary healthcare centers in Mallorca (Spain). All participants were 35 to 75-years-old and had poorly controlled hypertension. Patients were randomly assigned in a 1:1 ratio to a control group (usual care) or an intervention group (self-monitoring of blood pressure, self-titration of hypertensive medications, dietary interventions, and physical activity interventions). The primary outcome was decrease in the mean SBP at 6 months relative to baseline.ResultsA total of 153 participants were randomized to an intervention group (77) or a control group (76). After 6 months, the intervention group had a significantly lower systolic blood pressure (135.1 mmHg [±14.8] vs. 142.7 mmHg [±15.0], adjusted mean difference: 8.7 mmHg [95% CI: 3.4, 13.9], p

Entre los primeros dibujos para la construcción del palacio de Carlos V en la Alhambra se conserva una importante traza anónima en la Real Biblioteca de Madrid, que representa el edificio más unas plazas porticadas. Se ha estudiado poco su proceso de dibujo y aspectos técnicos como su escala y dimensiones, aquí analizados. Para ello se ha consultado y digitalizado la traza, transcribiéndose por primera vez sus trazados incisos. Su análisis revela la génesis de la planta, evidenciando significativas intenciones de diseño. También se estudian sus cotas, proporciones y la concordancia con lo construido, aportándose nuevos indicios sobre su finalidad y datación. Todo ello permite afirmar que estamos ante el primer plano de obra conocido del edificio, que determinó su forma y dimensiones definitivas. Se trata de un documento con valor patrimonial propio, imprescindible para entender y conservar un palacio incluido en la Lista de Patrimonio Mundial de la UNESCO.

The muqarnas are small pieces grouped together, adopting surprising three-dimensional forms. They are a symbol of identity of the 14th century Nasrid architecture at Alhambra in Granada. This research’s aim is to graphically analyze the plaster muqarnas dome located to the south of the Sala de los Reyes, in the Palacio de los Leones. The methodology followed combines historical images analysis and modern digital graphic techniques. First, a compilation of unpublished drawings and photographs documenting architectural transformations and significant alterations in the roof structures since the 16th century is provided. Although these muqarnas were drawn by Jones and Goury in the 19th century, the current research identifies and draws, digitally for the first time, its nearly two thousand pieces of this dome. Additionally, metric data of the current state has been collected using 3D laser scanning, revealing significant deformations. In this way, the knowledge of these fragile architectural elements is achieved to promote their heritage dissemination and to facilitate the conservation of a monumental site included in the UNESCO World Heritage List.

Purpose: The objective of this systematic review was to assess a possible relationship between stomatognathic alterations and idiopathic scoliosis (IS). Design: This study is a systematic review with meta-analysis of observational studies. Methods: The protocol of this systematic review with meta-analysis was registered in PROSPERO (CRD42022370593). A bibliographic search was carried out in the Pubmed (MEDLINE), Scopus, Web of Science and CINAHL databases using the MeSH terms ‘Scoliosis’ and ‘Stomatognathic Disease’. The odds ratio (OR) of prevalence and standardized mean difference (SMD) were used to synthesize the results. Results: Of 1592 studies located, 14 studies were selected with 3018 subjects (age: 13.9 years). IS was related to Angle’s class II (OR = 2.052, 95% CI = 1.236–3.406) and crossbite (OR = 2.234, 95% CI = 1.639–3.045). Patients with malocclusion showed a higher prevalence of IS than controls (OR = 4.633, 95% CI = 1.467–14.628), and subjects with IS showed high overjet (SMD = 0.405, 95% CI = 0.149–0.661) and greater dysfunction due to temporomandibular disorders (SMD = 1.153, 95% CI = 0.780–1.527). Conclusion: Compared with healthy controls, subjects with IS have twice the risk of suffering from occlusion disorders, present greater temporomandibular dysfunction and have a greater overjet in the incisors. Moreover, subjects with malocclusion have an IS prevalence up to four times higher. The systematic orofacial examination of patients with IS should be recommended.

The aim of this study is to evaluate the relationship between clinical severity and functionality, occupational performance, and health-related quality of life in patients hospitalized with pulmonary embolism. Pulmonary embolism patients were grouped by clinical severity using the Pulmonary Embolism Severity Index. Those scoring ≥160 were in the high-severity group (HSG); those scoring < 160 in the low–moderate group (LMSG). The main variables were functionality assessed by the World Health Organization Disability Assessment Schedule (WHODAS), self-perception of occupational performance assessed by the Canadian Occupational Performance Measure (COPM), pain and fatigue assessed by a Visual Analogue Scale (VAS), and health-related quality of life assessed by the EuroQol-5Dimensions (EQ-5D). Patients were evaluated at hospital admission and at 1-month and 3-month follow-up. At admission, there were significant differences between groups in the WHODAS and health-related quality of life in favor of the LMSG. At 1-month and at 3-month follow-up, there were significant differences between the LMSG and HSG in WHODAS, COMP, NRS pain, fatigue and EQ-5D scores in favor of the LMSG. An association exists between clinical severity and mid-term functionality, self-perception of occupational performance, pain, fatigue, and health-related quality of life in PE patients.

The city of Seville experienced a remarkable rise in the 16th century thanks to trade with America. Based on a report by the architect Hernán Ruiz, it was decided to renovate the gates of the walled city. The Puerta Real, also called Puerta de Goles, was remodelled between 1560 and 1566, and King Philip II entered through it in 1570. However, it was demolished around 1864, and only the remains of the adjacent wall stand today. This research aims to graphically analyse the gate and its immediate surroundings to gain a more profound knowledge of it and to promote its heritage value. To this end, an extensive collection and analysis of historical images has been carried out, which are essential for understanding the transformations of the site. A photograph by Masson (c. 1855–1860) was next used to support the virtual reconstruction of the gate. A 3D laser scanner was also used to document the existing archaeological remains and, via game-engine technology, to recreate rigorously, for the first time, this 16th-century gate in its current environment. This research could be useful for future scientific reconstruction to promote the heritage revitalisation of this city area.

Chiral pesticides that are still commercialized and incorporated into the environment as racemic mixtures of enantiomers require evaluation of the enantioselectivity of their biological activity and environmental fate processes for a better prediction of their field efficacy and environmental risks. In this work, we successfully separated the enantiomers of the chiral herbicide ethofumesate (ETFM), determined their absolute configuration, and characterized their herbicidal activity as well as their adsorption, degradation, enantiomerization, and leaching in Mediterranean agricultural soils. While the herbicidal activity of R-ethofumesate to the sensitive species Portulaca grandiflora was greater than that of S-ethofumesate, the adsorption, degradation, and leaching of the herbicide showed negligible enantioselectivity and enantiomer interconversion did not occur in soils. The adsorption of both enantiomers showed a positive correlation with the soil organic carbon content (r = 0.856, P = 0.015), and their degradation in soils occurred slowly (DT50 > 60 days) and at similar rates independent of their application as individual enantiomers or as a racemic mixture of enantiomers. The addition of three highly adsorptive materials to a scarcely adsorptive soil increased the adsorption of the enantiomers of ETFM and delayed their degradation without affecting the non-enantioselective character of the processes. As a result of their high adsorption capacity, the materials were highly effective in reducing the leaching of both enantiomers of ETFM through soil columns. The results of this work indicate that the application of single-enantiomer ETFM formulations, based on a higher herbicidal activity or a lower toxicity to non-target organisms of the formulated enantiomer, would reduce considerable exposure risks associated with incorporating into the environment the less favorable enantiomer, as this would show long persistence and high leaching potential in soils similar to its optical isomer.

We review the present status of the Standard Model calculation of the anomalous magnetic moment of the muon. This is performed in a perturbative expansion in the fine-structure constant α and is broken down into pure QED, electroweak, and hadronic contributions. The pure QED contribution is by far the largest and has been evaluated up to and including O(α5) with negligible numerical uncertainty. The electroweak contribution is suppressed by (mμ∕MW)2 and only shows up at the level of the seventh significant digit. It has been evaluated up to two loops and is known to better than one percent. Hadronic contributions are the most difficult to calculate and are responsible for almost all of the theoretical uncertainty. The leading hadronic contribution appears at O(α2) and is due to hadronic vacuum polarization, whereas at O(α3) the hadronic light-by-light scattering contribution appears. Given the low characteristic scale of this observable, these contributions have to be calculated with nonperturbative methods, in particular, dispersion relations and the lattice approach to QCD. The largest part of this review is dedicated to a detailed account of recent efforts to improve the calculation of these two contributions with either a data-driven, dispersive approach, or a first-principle, lattice-QCD approach. The final result reads aμSM=116591810(43)×10−11 and is smaller than the Brookhaven measurement by 3.7σ. The experimental uncertainty will soon be reduced by up to a factor four by the new experiment currently running at Fermilab, and also by the future J-PARC experiment. This and the prospects to further reduce the theoretical uncertainty in the near future – which are also discussed here – make this quantity one of the most promising places to look for evidence of new physics.

The performance of first-year students in electromagnetism (E&M) courses of different engineering degrees at a Spanish public university was measured using the Brief Electricity and Magnetism Assessment (BEMA), a standard research-based instrument to assess students' understanding after attending introductory courses in electricity and magnetism. In all cases, Flipped classroom (FC) built on information and communications technology was used. The objective of this paper is to analyse if the gain in the BEMA pre and post-test results is influenced by several factors such as the degree, the students' academic grade, and gender. Moreover, as some studies have shown that the students' retention of the concepts was significantly stronger in active learning than in traditional approaches, a third BEMA test was performed by the students to analyse the long-term retention gain dependence on the same factors. Students from different engineering degree programs were asked to complete two BEMA tests during the course and a third one after a few months. ANOVA tests were used to analyse the existence of significant differences in gain between student degree programs, student academic level and student gender. Results have shown no differences in the BEMA performance by degree program, but significant differences were found by academic level and gender. Retention did not depend on the degree course but on the academic level. Mean gain value by academic level, and gender was obtained and concluded that the best students presented the best gain results and that gain depends on the students' gender: males outperformed females in the BEMA tests, although there were no significant differences in the course grades. It is thus necessary to understand these differences and to implement measures in daily teaching work to improve women's performance.

Abstract We present the first unquenched lattice-QCD calculation of the form factors for the decay $$B\rightarrow D^*\ell \nu $$ B → D ∗ ℓ ν at nonzero recoil. Our analysis includes 15 MILC ensembles with $$N_f=2+1$$ N f = 2 + 1 flavors of asqtad sea quarks, with a strange quark mass close to its physical mass. The lattice spacings range from $$a\approx 0.15$$ a ≈ 0.15 fm down to 0.045 fm, while the ratio between the light- and the strange-quark masses ranges from 0.05 to 0.4. The valence b and c quarks are treated using the Wilson-clover action with the Fermilab interpretation, whereas the light sector employs asqtad staggered fermions. We extrapolate our results to the physical point in the continuum limit using rooted staggered heavy-light meson chiral perturbation theory. Then we apply a model-independent parametrization to extend the form factors to the full kinematic range. With this parametrization we perform a joint lattice-QCD/experiment fit using several experimental datasets to determine the CKM matrix element $$|V_{cb}|$$ | V cb | . We obtain $$\left| V_{cb}\right| = (38.40 \pm 0.68_{\text {th}} \pm 0.34_{\text {exp}} \pm 0.18_{\text {EM}})\times 10^{-3}$$ V cb = ( 38.40 ± 0 . 68 th ± 0 . 34 exp ± 0 . 18 EM ) × 10 - 3 . The first error is theoretical, the second comes from experiment and the last one includes electromagnetic and electroweak uncertainties, with an overall $$\chi ^2\text {/dof} = 126/84$$ χ 2 /dof = 126 / 84 , which illustrates the tensions between the experimental data sets, and between theory and experiment. This result is in agreement with previous exclusive determinations, but the tension with the inclusive determination remains. Finally, we integrate the differential decay rate obtained solely from lattice data to predict $$R(D^*) = 0.265 \pm 0.013$$ R ( D ∗ ) = 0.265 ± 0.013 , which confirms the current tension between theory and experiment.

Introduction Two blood brain-derived biomarkers, glial fibrillar acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), can rule out intracranial lesions in patients with mild traumatic brain injury (mTBI) when assessed within the first 12 hours. Most elderly patients were excluded from previous studies due to comorbidities. Biomarker use in elderly population could be affected by increased basal levels. This study will assess the performance of an automated test for measuring serum GFAP and UCH-L1 in elderly patients to predict the absence of intracranial lesions on head CT scans after mTBI, and determine both biomarkers reference values in a non-TBI elderly population.Methods and analysis This is a prospective multicentre observational study on elderly patients (≥65 years) that will be performed in Spain, France and Germany. Two patient groups will be included in two independent substudies. (1) A cohort of 2370 elderly patients (1185

Esta investigación desvela desconocidos y significativos detalles sobre los trazados auxiliares y la geometría de la traza del palacio de Carlos V en la Alhambra, conservada en el Archivo Histórico Nacional, utilizando una precisa reproducción digital. Ello ha permitido formular una hipótesis sobre su proceso de dibujo, y detectar algunos tanteos previos en este importante documento gráfico del primer Renacimiento español. Todo ello, junto a su comparación dimensional con otras trazas conocidas del propio palacio y con datos sobre la desaparecida maqueta, aporta nuevos indicios sobre sus fines, datación y autoría, cuestiones que aún son objeto de un abierto debate.

Motivated by the success of the flavour physics programme carried out overthe last decade at the Large Hadron Collider (LHC), we characterize in detailthe physics potential of its High-Luminosity and High-Energy upgrades in thisdomain of physics. We document the extraordinary breadth of the HL/HE-LHCprogramme enabled by a putative Upgrade II of the dedicated flavour physicsexperiment LHCb and the evolution of the established flavour physics role ofthe ATLAS and CMS general purpose experiments. We connect the dedicated flavourphysics programme to studies of the top quark, Higgs boson, and directhigh-$p_T$ searches for new particles and force carriers. We discuss thecomplementarity of their discovery potential for physics beyond the StandardModel, affirming the necessity to fully exploit the LHC's flavour physicspotential throughout its upgrade eras.

The e-portfolio is a tool increasingly used in Higher Education due to the benefits it holds, especially with regards to facilitating processes of evaluation and reflective learning. The main goal of this study was the construction of a questionnaire to analyse EP use in a Spanish University and to ensure its reliability and validity for use within relevant samples. To perform this task, we proposed a three-phase procedure: a development phase based on a literature review and the subsequent proposal of items; an evaluation phase, with revision based on experts' judgment; and an analysis phase, in which the instrument's reliability and validity (N = 251) were evaluated through factor analyses and descriptive statistical analyses according to dimension, degree of internal consistency and the relationships uncovered amongst the variables. As a result the Questionnaire on the E-Portfolio in Higher Education is proposed. It is composed of 32 items divided between three dimensions: Pedagogical considerations, academics' teaching and usability. The analyses performed show the questionnaire to be valid and reliable for its proposed purpose. The questionnaire may be useful for HE academics who use the EP and for educational administrators who wish to analyse educational practices of this kind.

This paper will study insurance data clustering using Support Vector Machine (SVM) approaches. It investigates the optimum condition employing the three most popular kernels of SVM, i.e., linear, polynomial, and radial basis kernel. To explore sum insured datasets, kernel comparisons for Root Mean Square Error (RMSE) and density analysis have been provided. It employs these kernels to classify based on sum insured datasets. The objective of this research is to demonstrate to industrial researchers that data grouping may be accomplished in an organized, error-free, and efficient manner utilizing R programming and the SVM approach. In this study, we check the insurance data for the sum insured with statistical methods in the form of Model Performance Evaluation (MPE), Receiver Operating Characteristics (ROC), Area Under Curve (AUC), partial AUC (pAUC), smoothing, confidence intervals, and thresholds. Then, sum insured data are followed up to classify using SVM kernels. This paper finds new ideas for evaluating insurance data using the SVM approach with multiple kernels. This novel research emphasizes the statistical analysis methods for insurance data and uses the SVM method for more accurate data classification. Finally, it informs that this research is a pure finding, and there has never been any research on this subject. This research was conducted using the sum insured data as a sample from the Office of the Insurance Commission (OIC) in Thailand as an independent insurance institution providing actual data. Doi: 10.28991/ESJ-2022-06-04-014 Full Text: PDF

Food and feed contamination with mycotoxins is a major public health concern. Humans and animals are exposed to these toxins by consuming contaminated products throughout their lives. In this study, a method based on dispersive liquid–liquid microextraction (DLLME), followed by liquid chromatography with fluorescence detection (LC-FLD), was validated for the determination of aflatoxins (AFs) M1, B1, B2, G1, G2, zearalenone (ZEN), and ochratoxin A (OTA). The method was applied to 150 raw cow milk samples and 90 market durum wheat samples from two Tunisian climatic regions: the littoral region (Mahdia) and the continental region (Béja). This work was carried out to obtain more surveillance data to support rapid initiatives to assure safe foods and protect consumer health and to estimate the daily exposure of the Tunisian population consuming those products. AFG2 and OTA were found in wheat with incidences of 54.4 and 11.1%, respectively. On the other side, milk samples were contaminated by AFG2, AFB1, and AFB2 with incidences of 8.7%, 2.0%, and 0.67%, respectively. Some of the samples showed OTA concentrations above the maximum limit allowed by the European Union, which represents a health risk for consumers in Tunisia, where no legislation exists about the maximum content of mycotoxins in food.

2-Methyl-4-chlorophenoxyacetic acid (MCPA) is a highly mobile herbicide that is frequently detected in global potable water sources. One potential mitigation strategy is the sorption on biochar to limit harm to unidentified targets. However, irreversible sorption could restrict bioefficacy thereby compromising its usefulness as a vital crop herbicide. This research evaluated the effect of pyrolysis temperatures (350, 500 and 800°C) on three feedstocks; poultry manure, rice hulls and wood pellets, particularly to examine effects on the magnitude and reversibility of MCPA sorption. Sorption increased with pyrolysis temperature from 350 to 800°C. Sorption and desorption coefficients were strongly corelated with each other (R2 = 0.99; P < .05). Poultry manure and rice hulls pyrolyzed at 800°C exhibited irreversible sorption while for wood pellets at 800°C desorption was concentration dependent. At higher concentrations some desorption was observed (36% at 50 ppm) but was reduced at lower concentrations (1-3% at < 5 ppm). Desorption decreased with increasing pyrolysis temperature. Sorption data were analyzed with Langmuir, Freundlich, Dubinin-Radushkevich and Temkin isotherm models. Freundlich isotherms were better predictors of MCPA sorption (R2 ranging from 0.78 to 0.99). Poultry manure and rice hulls when pyrolyzed at higher temperatures (500 and 800°C) could be used for remediation efforts (such as spills or water filtration), due to the lack of desorption observed. On the other hand, un-pyrolyzed feedstocks or biochars created at 350°C could perform superior for direct field applications to limit indirect losses including runoff and leaching, since these materials also possess the ability to release MCPA subsequently to potentially allow herbicidal action.

This work is a starting point for rethinking the role of the Iberian Peninsula in the neolithisation of northern Morocco. It focuses on the similarities and divergences between the first pottery productions and their decorations in both territories. This relationship is supported by the existence of an accurate chronological gradation between the first evidence of Neolithisation in Iberian Peninsula and that of northern Morocco which suggests a north–south direction. We also present arguments on the possible links between the early ceramics from the north of Morocco and those from the south of Iberia, providing a first approach to an issue that will need to be carefully analysed in future research.

Choline is an essential nutrient that plays a role in the synthesis of the phospholipid membrane, critical for cell functions, and it is the major source of methyl donors relevant for epigenetic modifications of the genome [...]

Seville experienced great splendour during the 16th Century as the European centre for trade with the Americas. At that time, religious institutions and charitable hospitals gathered significant real-estate heritage. To facilitate its management, literary documents called apeos were drawn up, which exhaustively and reliably described the main architectural features of the buildings, including their general measurements. In this research, approximately 1,700 of these apeos, conserved in various archives of Seville, are studied.A new methodology of architectural graphic analysis has been followed in order to understand the organisation of spaces in 16th–Century Sevillian domestic life: historical texts have been turned into drawings. In addition, information on the architectural elements described has been compiled using databases. To draw the plans, it was necessary to locate the current lot of each property. In certain cases, schematic elevations and volumes have also been drawn. By taking into account the uses and areas, a typological classification into four groups has been made: houses, courtyard tenement housing, inns, and shops. Their main architectural characteristics have been identified through the application of comparative graphic diagrams. Finally, all the information has been superimposed over street plans of the city after considering its urban evolution. In this way, different items of data have been spatially related and a global vision of the transformations and permanence over time is provided. The investigation remains open since many apeos from the 16th and 17th Centuries have yet to be studied, plus several buildings that are still standing today.DOI: https://doi.org/10.20365/disegnarecon.26.2021.4

Durante sus viajes por España en 1830–1833, Richard Ford realizó cientos de dibujos de los lugares visitados, cuyo conjunto no se ha conocido hasta una exposición en 2014. En esta investigación se analizan por primera vez sus dibujos sobre el entorno geográfico de Gibraltar, en gran parte inéditos. Primero se presentan sus apuntes del relieve costero tomados en barco desde el mar, después visiones lejanas del Estrecho desde Gaucín, panorámicas de la bahía de Algeciras, vistas del Peñón y sus fortificaciones, más bocetos de vegetación y personajes. Los dibujos no tenían pretensiones artísticas ni comerciales, pero aportan una rigurosa descripción que se complementa con los textos que el propio autor publicó en su famoso libro A Handbook for Travellers in Spain (1845). Como referencia comparativa también se han considerado imágenes y textos sobre Gibraltar de otros autores diversos. Las precisas observaciones de Ford, previas a la aparición de la fotografía, tienen un excepcional valor documental como testimonio gráfico y literario que facilita la comprensión de este singular territorio y su paisaje en el siglo XIX.

Adolescence is a late developmental period marked by pronounced reorganization of brain networks in which epigenetic mechanisms play a fundamental role. This brain remodeling is associated with a peculiar behavior characterized by novelty seeking and risky activities such as alcohol and drug abuse, which is associated with increased susceptibility to stress. Hence, adolescence is a vulnerable postnatal period since short- and long-term deleterious effects of alcohol drinking and drug abuse are a serious worldwide public health concern. Among several other consequences, it has been proposed that exposure to stress, alcohol, or other drugs disrupts epigenetic mechanisms mediated by small non-coding microRNAs (miRNAs). During adolescence, this modifies the expression of a variety of genes involved in neurodevelopmental processes such as proliferation, differentiation, synaptogenesis, neural plasticity, and apoptosis. Hence, the effect of miRNAs dysregulation during adolescence might contribute to a long-term impact on brain function. This systematic review focuses on the miRNA expression patterns in the adolescent rodent brain with special interest in the impact of stress and drugs such as amphetamine, cocaine, nicotine, cannabis, and ketamine. The results point to a relevant and complex role of miRNAs in the regulation of the molecular processes involved in adolescent brain development as part of a dynamic epigenetic network sensitive to environmental events with distinctive changes across adolescence. Several miRNAs have been assessed evidencing changing expression profiles during the adolescent transition which are altered by exposure to stress and drug abuse. Since this is an emerging rapidly growing field, updating the present knowledge will contribute to improving our understanding of the epigenetic regulation mechanisms involved in the neurodevelopmental changes responsible for adolescent behavior. It can be expected that increased knowledge of the molecular mechanisms mediating the effect of environmental threats during the adolescent critical developmental period will improve understanding of psychiatric and addictive disorders emerging at this stage.

Nowadays, the educational methodology known as "peer assessment" constitutes one of the pillars of formative assessment at the different levels of the educational system, particularly at the University level. In fact, in recent years, it has been increasingly used to enhance students' meaningful learning, as it is considered to be an element of social learning, in which students benefit from the lessons learned by other classmates, and draw upon the ability to assess the quality of the learning, contrasting it with the level of knowledge that each has about the subject/course being evaluated, and using common evaluation criteria. In this regard, this paper represents the experience of two groups of students. It allows us to determine how many peer assessments should be required of students in a particular course in order to constitute a serious, reliable activity. On the other hand, from the point of view of the student, the assessments are evaluated to the extent that they are seen as a required and mandatory exercise that must be carried out by students simply to pass the course. In the later case, the activity can become extremely trivial and banal. Statistical analysis of the results indicates that three peer assessments per student appraised represents an adequate number. On the other hand, more than thirty peer assessments fail to contribute to learning, nor do they represent serious activities.

This study analyzes the use of e-portfolios in Higher Education, specifically, participants' opinion concerning various aspects of the experience and the teaching methods used. Its main purpose is to determine the influence of professors in student satisfaction in this virtual environment, through a descriptive study performed using a mixed focus that combines quantitative and qualitative data analysis. The data collection instruments were a questionnaire for recording the students' opinions and a structured interview of three professors. The study's sample of 251 was drawn from students who were enrolled in different subjects. According to the results obtained, the professor is a decisive variable in student satisfaction when analyzing pedagogical issues concerning the e-portfolio, students' opinions about the professor's teaching actions, and usability of the platform. The students' opinions differ most on issues of time management and collaborative learning, but also on issues such as participation, motivation, and reflection on learning.

Understanding how drought propagates from meteorological to agricultural drought requires further research into the combined effects of soil moisture, evapotranspiration, and precipitation, especially through the analysis of long-term data. To this end, the present study examined a multi-year reanalysis dataset (ERA5-Land) that included numerous drought events across the Iberian Peninsula, with a specific emphasis on the 2005 episode. Through this analysis, the mechanisms underlying the transition from meteorological to agricultural drought and its features for the selected region were investigated. To identify drought episodes, various non-parametric standardized drought indices were utilized. For meteorological droughts, the Standardized Precipitation-Evapotranspiration Index (SPEI) was employed, while the Standardized Soil Moisture Index (SSI), Multivariate Standardized Drought Index (MSDI), and Standard Precipitation, Evapotranspiration and Soil Moisture Index (SPESMI) were utilized for agricultural droughts, while their ability to identify relative vegetation stress in areas affected by severe droughts was investigated using the Fraction of Absorbed Photosynthetically Active Radiation (FAPAR) Anomaly provided by the Copernicus European Drought Observatory (EDO). A statistical approach based on run theory was employed to analyze several characteristics of drought propagation, such as response time scale, propagation probability, and lag time at monthly, seasonal, and six-month time scales. The retrieved response time scale was fast, about 1–2 months, and the probability of occurrence increased with the severity of the originating meteorological drought. The duration of agricultural drought was shorter than that of meteorological drought, with a delayed onset but the same term. The results obtained by multi-variate indices showed a more rapid propagation process and a tendency to identify more severe events than uni-variate indices. In general terms, agricultural indices were found to be effective in assessing vegetation stress in the Iberian Peninsula. A newly developed combined agricultural drought index was found to balance the characteristics of the other adopted indices and may be useful for future studies.