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Madison Fraser,1 Nagashree Seetharamu,2 Matthew Diamond,2 Chung-Shien Lee2,3 1Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hofstra University, Hempstead, NY, USA; 2Division of Medical Oncology and Hematology, Northwell Health Cancer Institute, Lake Success, NY, USA; 3Department of Clinical Health Professions, St. John’s University, Queens, NY, USACorrespondence: Chung-Shien Lee, Email leec3@stjohns.eduAbstract: Aberrant c-MET (Mesenchymal–Epithelial Transition) signaling contributes to cancer cell development, proliferation, and metastases of non-small cell lung cancer (NSCLC). MET exon 14 (METex14) skipping mutation is noted in approximately 4% of NSCLC cases and is targetable with the recently approved tyrosine kinase inhibitors capmatinib and tepotinib. Capmatinib, the focus of this review article, is a highly selective MET inhibitor approved for use in patients with METex14 mutated NSCLC. In this review, we discuss cMET as a target, the pharmacology of capmatinib, key trials of capmatinib in MET-altered lung cancer, and toxicity profile. We highlight some ongoing capmatinib clinical trials that expand their role to other subsets of patients, especially those with EGFR mutations, who develop MET alterations as a resistance pathway. We further provide our perspective on the management of METex14 NSCLC, strategies for sequencing agents, and toxicity management.Keywords: non-small cell lung cancer, Mesenchymal–Epithelial Transition gene, MET exon 14 skipping mutation, tyrosine kinase inhibitor, capmatinib

Several thousand core-collapse supernovae (CCSNe) of different flavors have been discovered so far. However, identifying their progenitors has remained an outstanding open question in astrophysics. Studies of SN host galaxies have proven to be powerful in providing constraints on the progenitor populations. In this paper, we present all CCSNe detected between 2009 and 2017 by the Palomar Transient Factory. This sample includes 888 SNe of 12 distinct classes out to redshift z ≈ 1. We present the photometric properties of their host galaxies from the far-ultraviolet to the mid-infrared and model the host-galaxy spectral energy distributions to derive physical properties. The galaxy mass function of Type Ic, Ib, IIb, II, and IIn SNe ranges from 105 to 1011.5 M o˙, probing the entire mass range of star-forming galaxies down to the least-massive star-forming galaxies known. Moreover, the galaxy mass distributions are consistent with models of star-formation-weighted mass functions. Regular CCSNe are hence direct tracers of star formation. Small but notable differences exist between some of the SN classes. Type Ib/c SNe prefer galaxies with slightly higher masses (i.e., higher metallicities) and star formation rates than Type IIb and II SNe. These differences are less pronounced than previously thought. H-poor superluminous supernovae (SLSNe) and SNe Ic-BL are scarce in galaxies above 1010 M o˙. Their progenitors require environments with metallicities of < 0.4 and < 1 solar, respectively. In addition, the hosts of H-poor SLSNe are dominated by a younger stellar population than all other classes of CCSNe. Our findings corroborate the notion that low metallicity and young age play an important role in the formation of SLSN progenitors.

We present DES16C3cje, a low-luminosity, long-lived type II supernova (SN II) at redshift 0.0618, detected by the Dark Energy Survey (DES). DES16C3cje is a unique SN. The spectra are characterized by extremely narrow photospheric lines corresponding to very low expansion velocities of1500 km s-1, and the light curve shows an initial peak that fades after 50 d before slowly rebrightening over a further 100 d to reach an absolute brightness of Mr ∼-15.5 mag. The decline rate of the late-time light curve is then slower than that expected from the powering by radioactive decay of 56Co, but is comparable to that expected from accretion power. Comparing the bolometric light curve with hydrodynamical models, we find that DES16C3cje can be explained by either (i) a low explosion energy (0.11 foe) and relatively large 56Ni production of 0.075 M· from an ∼15 M· red supergiant progenitor typical of other SNe II, or (ii) a relatively compact ∼40 M· star, explosion energy of 1 foe, and 0.08 M· of 56Ni. Both scenarios require additional energy input to explain the late-time light curve, which is consistent with fallback accretion at a rate of ∼0.5 × 10-8 M· s-1.

Creating and maintaining sustainable transportation systems depends in part on understanding and mitigating ecological impacts. Wildlife crossing structures (WCS) are often used to mitigate impacts on wildlife populations. WCS and existing structures may provide passage for multiple species, depending on their sensitivity to traffic disturbance and perception of the roadway. In a previous project, the research team found that traffic conditions and traffic noise could reduce WCS effectiveness in facilitating passage of diverse and sensitive species. In the current project, they expanded the geographic scope to 26 sites throughout California, including detailed measurements of vehicle noise and lighting impacts on wildlife use of structures. They investigated individual animal behavior as the animals approached structures as a possible mechanism for reducing species diversity due to traffic disturbance. In order to inform future WCS planning, placement and construction, the team studied traffic noise and light impacts on wildlife in the vicinity of the proposed Liberty Canyon wildlife over-crossing (over US 101), the first and largest of its kind in California. They improved a preliminary statistical model of the effects of traffic on WCS use of existing structures. The authors recommend strategies for transportation agencies to use in developing and modifying WCS to improve wildlife passage.View the NCST Project Webpage

This paper describes the rapidly evolving and unusual supernova LSQ13ddu, discovered by the La Silla-QUEST survey. LSQ13ddu displayed a rapid rise of just 4.8 ± 0.9 d to reach a peak brightness of −19.70 ± 0.02 mag in the LSQgr band. Early spectra of LSQ13ddu showed the presence of weak and narrow He I features arising from interaction with circumstellar material (CSM). These interaction signatures weakened quickly, with broad features consistent with those seen in stripped-envelope SNe becoming dominant around two weeks after maximum. The narrow He I velocities are consistent with the wind velocities of luminous blue variables but its spectra lack the typically seen hydrogen features. The fast and bright early light curve is inconsistent with radioactive 56Ni powering but can be explained through a combination of CSM interaction and an underlying 56Ni decay component that dominates the later time behaviour of LSQ13ddu. Based on the strength of the underlying broad features, LSQ13ddu appears deficient in He compared to standard SNe Ib.

We present light curves and spectra of the tidal disruption event (TDE) ASASSN-18pg/AT 2018dyb spanning a period of one year. The event shows a plethora of strong emission lines, including the Balmer series, He ii, He i, and metal lines of O iii λ3760 and N iii λλ4100, 4640 (blended with He ii). The latter lines are consistent with originating from the Bowen fluorescence mechanism. By analyzing literature spectra of past events, we conclude that these lines are common in TDEs. The spectral diversity of optical TDEs is thus larger than previously thought and includes N-rich events besides H- and He-rich events. We study how the spectral lines evolve with time, by means of their width, relative strength, and velocity offsets. The velocity width of the lines starts at ∼13,000 km s-1 and decreases with time. The ratio of He ii to N iii increases with time. The same is true for ASASSN-14li, which has a very similar spectrum to AT 2018dyb but its lines are narrower by a factor of >2. We estimate a black hole mass of M BH = 3.3-2.0+5.0 × 106 Mo˙ by using the M-σ relation. This is consistent with the black hole mass derived using the MOSFiT transient fitting code. The detection of strong Bowen lines in the optical spectrum is an indirect proof for extreme ultraviolet and (reprocessed) X-ray radiation and favors an accretion origin for the TDE optical luminosity. A model where photons escape after multiple scatterings through a super-Eddington thick disk and its optically thick wind, viewed at an angle close to the disk plane, is consistent with the observations.

We present high-cadence UV, optical, and near-infrared data on the luminous Type II-P supernova SN 2017gmr from hours after discovery through the first 180 days. SN 2017gmr does not show signs of narrow, high-ionization emission lines in the early optical spectra, yet the optical light-curve evolution suggests that an extra energy source from circumstellar medium (CSM) interaction must be present for at least 2 days after explosion. Modeling of the early light curve indicates a ∼500 R o progenitor radius, consistent with a rather compact red supergiant, and late-time luminosities indicate that up to 0.130 ± 0.026 M o of 56Ni are present, if the light curve is solely powered by radioactive decay, although the 56Ni mass may be lower if CSM interaction contributes to the post-plateau luminosity. Prominent multipeaked emission lines of Hα and [O i] emerge after day 154, as a result of either an asymmetric explosion or asymmetries in the CSM. The lack of narrow lines within the first 2 days of explosion in the likely presence of CSM interaction may be an example of close, dense, asymmetric CSM that is quickly enveloped by the spherical supernova ejecta.

Abstract Purpose To find the best level to measure aortic flow for quantification of aortic regurgitation (AR) in 4D flow CMR. Methods In 27 congenital heart disease patients with AR (67% male, 31 ± 16 years) two blinded observers measured antegrade, retrograde, net aortic flow volumes and regurgitant fractions at 6 levels in 4D flow: (1) below the aortic valve (AV), (2) at the AV, (3) at the aortic sinus, (4) at the sinotubular junction, (5) at the level of the pulmonary arteries (PA) and (6) below the brachiocephalic trunk. 2D phase contrast (2DPC) sequences were acquired at the level of PA. All patients received prior transthoracic echocardiography (TTE) with AR severity grading according to a recommended multiparametric approach. Results After assigning 2DPC measurements into AR grading, agreement between TTE AR grading and 2DPC was good (κ = 0.88). In 4D flow, antegrade flow was similar between the six levels (p = 0.87). Net flow was higher at level 1–2 than at levels 3–6 (p

Lacking the ability to follow individual galaxies on cosmological time-scales, our understanding of individual galaxy evolution is broadly inferred from population trends and behaviours. In its most prohibitive form, this approach assumes that galactic star formation properties exhibit ergodicity, so that individual galaxy evolution can be statistically inferred via ensemble behaviours. The validity of this assumption is tested through the use of observationally motivated simulations of isolated galaxies. The suite of simulated galaxies is statistically constructed to match observed galaxy properties by using kernel density estimation to create structural parameter distributions, augmented by theoretical relationships where necessary. We also test the impact of different physical processes, such as stellar winds or the presence of halo substructure on the star formation behaviour. We consider the subtleties involved in constraining ergodic properties, such as the distinction between stationarity imposed by stellar wind feedback and truly ergodic behaviour. However, without sufficient variability in star formation properties, individual galaxies are unable to explore the full parameter space. While, as expected, full ergodicity appears to be ruled out, we find reasonable evidence for partial ergodicity, where averaging over mass-selected subsets of galaxies more broadly resembles time averages, where the average largest deviation across physical scenarios is 0.20 dex. As far as we are aware, this the first time partial ergodicity has been considered in an astronomical context, and provides a promising statistical concept. Despite morphological changes introduced by close encounters with dark matter substructure, subhaloes are not found to significantly increase deviations from ergodic assumptions. [ABSTRACT FROM AUTHOR]

Ying Ru Feng,1 Lynn Meuleners,1 Mark Stevenson,2,3 Jane Heyworth,4 Kevin Murray,4 Michelle Fraser,1 Sean Maher5 1Western Australian Centre for Road Safety Research, School of Population and Global Health, The University of Western Australia, Perth, WA, Australia; 2Transport, Health and Urban Design Research Lab, Melbourne School of Design, University of Melbourne, Melbourne, VIC, Australia; 3Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; 4School of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia; 5Department of Rehabilitation and Aged Care, Sir Charles Gairdner Hospital, Perth, WA, AustraliaCorrespondence: Lynn MeulenersWestern Australian Centre for Road Safety Research, School of Population and Global Health, The University of Western Australia (M431), 35 Stirling Hwy, Perth, WA, 6009, AustraliaTel +61 8 6488 7375Email lynn.meuleners@uwa.edu.auPurpose: Mild cognitive impairment can impact driving performance and self-regulation practices. However, there is little evidence on how cognitive impairment may impact these self-regulation practices over a period of time. Therefore, the aim of this study was to examine changes in the number and type of situations in which older drivers with and without suspected mild cognitive impairment (MCI) self-regulate their driving over a one-year period, after accounting for relevant confounders.Participants and Methods: A longitudinal cohort study involving older drivers (65+ years) from metropolitan Western Australia was interviewed by a telephone interview at baseline and one-year follow-up. The Telephone Cognitive Screen (T-CogS) was also administered to determine changes in their cognitive status. The outcome of interest was the number and type of situations older drivers self-regulated their driving.Results: A total of 670 drivers were interviewed at baseline (suspected MCI: n = 227; no cognitive impairment: n = 443) and one-year follow-up (suspected MCI: n = 251; no cognitive impairment: n = 419), which provided 1340 observations. Drivers with suspected MCI increased the number of driving situations in which they self-regulated by 13% over a period of one-year compared with drivers without cognitive impairment (IRR = 1.13, 95% CI = 1.02– 1.27, p = 0.025). Specifically, drivers with suspected MCI had 60% increased odds of self-regulating when “making turns across oncoming traffic” compared with drivers without cognitive impairment (unadjusted OR = 1.60, 95% CI = 1.02– 2.53, p = 0.041). Other significant factors included being female (IRR = 1.87, 95% = 1.52– 2.32, p = 0.001), aged 75+ years (IRR = 1.33, 95% CI = 1.10– 1.60, p = 0.003), higher number of comorbidities (1– 3 comorbidities: IRR = 1.26, 95% CI = 1.01– 1.58, p = 0.040; 4+ comorbidities: IRR = 1.39, 95% CI = 1.08– 1.78, p = 0.011), “decreased driving confidence” (IRR = 1.32, 95% CI = 1.10– 1.58, p-value = 0.003) and “preference of having someone else drive” (IRR = 1.38, 95% CI = 1.12– 1.70, p = 0.003). Having one or more traffic infringements was also associated with a decrease in the number of self-regulated driving situations (IRR = 0.80, 95% CI = 0.67– 0.95, p = 0.011).Conclusion: Over a one-year period, drivers with suspected MCI increased the number of situations in which they self-regulated their driving compared with drivers without cognitive impairment, particularly when “making turns across oncoming traffic”. Future studies should examine whether this increase in the types and number of self-regulated driving situations is enough to compensate for declines in cognition.Keywords: longitudinal, cognitive decline, driving behaviour, driving restriction, driving patterns

Anthropogenic noise is pervasive across the landscape and can be present at two temporal scales: acute (occurring sporadically and stochastically over the shortest time scales, e.g., milliseconds), and chronic (more persistent than instantaneous and occurring over longer timescales, e.g., minutes, days). Acute and chronic anthropogenic noise may induce a behavioral fear-mediated response in wildlife that is analogous to a prey response to predators. Understanding wildlife responses to anthropogenic noise is especially important in the case of wildlife crossing structures that provide wildlife with access to resources across busy roadways. Focusing on two species common at wildlife crossing structures, mule deer (Odocoileus hemionus) and coyotes (Canis latrans), we addressed the hypotheses that (1) acute traffic noise causes flight behavior; and (2) chronic traffic noise causes changes in a range of behaviors associated with the vigilance–foraging trade-off (vigilance, running, and foraging). We placed camera traps at entrances to ten crossing structures for a period of ∼ 2 months each throughout California, USA. Mule deer and coyotes demonstrated a flight response to acute traffic noise at entrances to crossing structures. Both species demonstrated shifts in behavioral response to chronic traffic noise within and among structures. Coyote behavior was indicative of fear, demonstrating increased vigilance at louder times within crossing structures, and switching from vigilance to running activity at louder crossings. Mule deer responded positively, increasing foraging at both spatial scales, and demonstrating decreased vigilance at louder structures, potentially using crossing structures as a Human Shield. Our results are the first to demonstrate that anthropogenic noise at crossing structures could alter wildlife passage, and that variations in fear response to anthropogenic noise exist across temporal, spatial, and amplitude scales. This dynamic response could alter natural predator-prey interactions and scale up to ecosystem-level consequences such as trophic cascades in areas with roads.

Abstract Aims Inflammation is thought to play a role in heart failure (HF) pathophysiology. Neutrophil‐to‐lymphocyte ratio (NLR) is a simple, routinely available measure of inflammation. Its relationship with other inflammatory biomarkers and its association with clinical outcomes in addition to other risk markers have not been comprehensively evaluated in HF patients. Methods We evaluated patients with worsening or new‐onset HF from the BIOlogy Study to Tailored Treatment in Chronic Heart Failure (BIOSTAT‐CHF) study who had available NLR at baseline. The primary outcome was time to all‐cause mortality or HF hospitalization. Outcomes were validated in a separate HF population. Results 1622 patients were evaluated (including 523 ventricular ejection fraction [LVEF]

Ying Ru Feng,1 Lynn Meuleners,1 Mark Stevenson,2,3 Jane Heyworth,4 Kevin Murray,4 Michelle Fraser,1 Sean Maher5 1Western Australian Centre for Road Safety Research, School of Population and Global Health, The University of Western Australia, Perth, WA, Australia; 2Transport, Health and Urban Design Research Lab, Melbourne School of Design, University of Melbourne, Melbourne, VIC, Australia; 3Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; 4School of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia; 5Department of Rehabilitation and Aged Care, Sir Charles Gairdner Hospital, Perth, WA, AustraliaCorrespondence: Lynn MeulenersWestern Australian Centre for Road Safety Research, School of Population and Global Health, The University of Western Australia (M431), 35 Stirling Highway, Crawley, WA, 6009, AustraliaTel +61 8 6488 7375Email lynn.meuleners@uwa.edu.auPurpose: Mild cognitive impairment and gender can impact different aspects of driving performance and behaviour in older drivers. However, there is little evidence on how these may affect naturalistic speeding behaviour. Therefore, the aim of this study was to examine the relationship between speeding events and cognitive status for older male and female drivers.Participants and Methods: A naturalistic driving study collected objective driving information over a two-week period using an in-vehicle monitoring device from 36 older drivers with suspected mild cognitive impairment and 35 older drivers without cognitive impairment. The outcome of interest examined was the number of speeding events, defined as travelling 5+ km/h over the posted speed limit for at least a minute.Results: The majority of participants (n=58, 81.69%) did not have a speeding event during the two-week monitoring period. Twenty-three speeding events were recorded among seven drivers with suspected mild cognitive impairment and six drivers without cognitive impairment. The majority of speeding events (82.61%) were by older male drivers and occurred in 60km/h and 70km/h speed zones. The results of the two negative binomial regression models found that in older male drivers, suspected mild cognitive impairment (IRR=7.45, 95% CI=1.53– 36.15, p=0.01) was associated with a significantly higher rate of speeding events, while increasing age was associated with a lower rate of speeding events (IRR=0.80, 95% CI=0.64– 1.00, p=0.04). For older female drivers, there were no factors significantly associated with the rate of speeding events.Conclusion: While the overall number of speeding events were infrequent, suspected mild cognitive impairment was associated with a significant increase in the rate of speeding events for older male drivers, but not for older female drivers. Speeding interventions and injury prevention policy strategies may need to be targeted differently for male and female drivers with mild cognitive impairment.Keywords: naturalistic, driver monitoring, cognitive decline, gender differences, driving behaviour

We present the results of optical, near-infrared, and mid-infrared observations of M101 OT2015-1 (PSN J14021678+5426205), a luminous red transient in the Pinwheel galaxy (M101), spanning a total of 16 years. The light curve showed two distinct peaks with absolute magnitudes Mr ≤ -12.4 and Mr ∼ -12, on 2014 November 11 and 2015 February 17, respectively. The spectral energy distributions during the second maximum show a cool outburst temperature of ≈3700 K and low expansion velocities (≈-300 km s-1) for the H I, Ca II, Ba II, and K I lines. From archival data spanning 15-8 years before the outburst, we find a single source consistent with the optically discovered transient, which we attribute to being the progenitor; it has properties consistent with being an F-type yellow supergiant with L ∼ 8.7×104 L-, Teff ≈ 7000 K, and an estimated mass of M1 = 18 ± 1 M-. This star has likely just finished the H-burning phase in the core, started expanding, and is now crossing the Hertzsprung gap. Based on the combination of observed properties, we argue that the progenitor is a binary system, with the more evolved system overfilling the Roche lobe. Comparison with binary evolution models suggests that the outburst was an extremely rare phenomenon, likely associated with the ejection of the common envelope of a massive star. The initial mass of the primary fills the gap between the merger candidates V838 Mon (5-10 M-) and NGC 4490-OT (30M-).

We present a pan-chromatic study of AT2017bcc, a nuclear transient that was discovered in 2017 within the skymap of a reported burst-like gravitational-wave candidate, G274296. It was initially classified as a superluminous supernova, and then reclassified as a candidate tidal disruption event. Its optical light curve has since shown ongoing variability with a structure function consistent with that of an active galactic nucleus, however, earlier data show no variability for at least 10 yr prior to the outburst in 2017. The spectrum shows complex profiles in the broad Balmer lines: a central component with a broad-blue wing, and a boxy component with time-variable blue and red shoulders. The H α emission profile is well modelled using a circular accretion disc component, and a blue-shifted double Gaussian which may indicate a partially obscured outflow. Weak narrow lines, together with the previously flat light curve, suggest that this object represents a dormant galactic nucleus which has recently been re-activated. Our time-series modelling of the Balmer lines suggests that this is connected to a disturbance in the disc morphology, and we speculate this could involve a sudden violent event such as a tidal disruption event involving the central supermassive black hole, though this cannot be confirmed, and given an estimated black hole mass of ≳ 107–108 M⊙ instabilities in an existing disc may be more likely. Although we find that the redshifts of AT2017bcc (z  = 0.13) and G274296 (z > 0.42) are inconsistent, this event adds to the growing diversity of both nuclear transients and multimessenger contaminants. [ABSTRACT FROM AUTHOR]

Context. We investigate two stripped-envelope supernovae (SNe) discovered in the nearby galaxy NGC 5806 by the (intermediate) Palomar Transient Factory [(i)PTF]. These SNe, designated PTF12os/SN 2012P and iPTF13bvn, exploded within ∼520 days of one another at a similar distance from the host-galaxy center. We classify PTF12os as a Type IIb SN based on our spectral sequence; iPTF13bvn has previously been classified as Type Ib having a likely progenitor with zero age main sequence (ZAMS) mass below ∼17 M⊙. Because of the shared and nearby host, we are presented with a unique opportunity to compare these two SNe. Aims. Our main objective is to constrain the explosion parameters of iPTF12os and iPTF13bvn, and to put constraints on the SN progenitors. We also aim to spatially map the metallicity in the host galaxy, and to investigate the presence of hydrogen in early-time spectra of both SNe. Methods. We present comprehensive datasets collected on PTF12os and iPTF13bvn, and introduce a new automatic reference-subtraction photometry pipeline (FPipe) currently in use by the iPTF. We perform a detailed study of the light curves (LCs) and spectral evolution of the SNe. The bolometric LCs are modeled using the hydrodynamical code hyde. We analyze early spectra of both SNe to investigate the presence of hydrogen; for iPTF13bvn we also investigate the regions of the Paschen lines in infrared spectra. We perform spectral line analysis of helium and iron lines to map the ejecta structure of both SNe. We use nebular models and late-time spectroscopy to constrain the ZAMS mass of the progenitors. We also perform image registration of ground-based images of PTF12os to archival HST images of NGC 5806 to identify a potential progenitor candidate. Results. We find that our nebular spectroscopy of iPTF13bvn remains consistent with a low-mass progenitor, likely having a ZAMS mass of ∼12M⊙. Our late-time spectroscopy of PTF12os is consistent with a ZAMS mass of ∼15M⊙. We successfully identify a source in pre-explosion HST images coincident with PTF12os. The colors and absolute magnitude of this object are consistent between pre-explosion and late-time HST images, implying it is a cluster of massive stars. Our hydrodynamical modeling suggests that the progenitor of PTF12os had a compact He core with a mass of 3.25+ 0.77-0.56M⊙ at the time of the explosion, which had a total kinetic energy of 0.54+ 0.41-0.25 × 1051 erg and synthesized 0.063+ 0.020-0.011M⊙ of strongly mixed 56Ni. Spectral comparisons to the Type IIb SN 2011dh indicate that the progenitor of PTF12os was surrounded by a thin hydrogen envelope with a mass lower than 0.02M⊙. We also find tentative evidence that the progenitor of iPTF13bvn could have been surrounded by a small amount of hydrogen prior to the explosion. This result is supported by possible weak signals of hydrogen in both optical and infrared spectra.

Context. We investigate two stripped-envelope supernovae (SNe) discovered in the nearby galaxy NGC 5806 by the (intermediate) Palomar Transient Factory [(i)PTF]. These SNe, designated PTF12os/SN 2012P and iPTF13bvn, exploded within ∼520 days of one another at a similar distance from the host-galaxy center. We classify PTF12os as a Type IIb SN based on our spectral sequence; iPTF13bvn has previously been classified as Type Ib having a likely progenitor with zero age main sequence (ZAMS) mass below ∼17 M⊙. Because of the shared and nearby host, we are presented with a unique opportunity to compare these two SNe. Aims. Our main objective is to constrain the explosion parameters of iPTF12os and iPTF13bvn, and to put constraints on the SN progenitors. We also aim to spatially map the metallicity in the host galaxy, and to investigate the presence of hydrogen in early-time spectra of both SNe. Methods. We present comprehensive datasets collected on PTF12os and iPTF13bvn, and introduce a new automatic reference-subtraction photometry pipeline (FPipe) currently in use by the iPTF. We perform a detailed study of the light curves (LCs) and spectral evolution of the SNe. The bolometric LCs are modeled using the hydrodynamical code hyde. We analyze early spectra of both SNe to investigate the presence of hydrogen; for iPTF13bvn we also investigate the regions of the Paschen lines in infrared spectra. We perform spectral line analysis of helium and iron lines to map the ejecta structure of both SNe. We use nebular models and late-time spectroscopy to constrain the ZAMS mass of the progenitors. We also perform image registration of ground-based images of PTF12os to archival HST images of NGC 5806 to identify a potential progenitor candidate. Results. We find that our nebular spectroscopy of iPTF13bvn remains consistent with a low-mass progenitor, likely having a ZAMS mass of ∼12M⊙. Our late-time spectroscopy of PTF12os is consistent with a ZAMS mass of ∼15M⊙. We successfully identify a source in pre-explosion HST images coincident with PTF12os. The colors and absolute magnitude of this object are consistent between pre-explosion and late-time HST images, implying it is a cluster of massive stars. Our hydrodynamical modeling suggests that the progenitor of PTF12os had a compact He core with a mass of 3.25+ 0.77-0.56M⊙ at the time of the explosion, which had a total kinetic energy of 0.54+ 0.41-0.25 × 1051 erg and synthesized 0.063+ 0.020-0.011M⊙ of strongly mixed 56Ni. Spectral comparisons to the Type IIb SN 2011dh indicate that the progenitor of PTF12os was surrounded by a thin hydrogen envelope with a mass lower than 0.02M⊙. We also find tentative evidence that the progenitor of iPTF13bvn could have been surrounded by a small amount of hydrogen prior to the explosion. This result is supported by possible weak signals of hydrogen in both optical and infrared spectra.

This paper describes a generalizable planning and assessment process fortransportation planning adaptive to sea level rise (SLR). State Route 37(SR-37) is the California highway most vulnerable to temporary floodingand permanent inundation as a result of SLR. Like many other coastal highwaysin the United States, SR-37 is adjacent to protected coastal systems(e.g., beaches, tidal wetlands), meaning that any activity on the highway issubject to regulatory oversight. Both SR-37 and the surrounding marshesare vulnerable to the effects of SLR. Because of a combination of congestionand threats from SLR, planning for a new highway adaptive and resilientto SLR impacts was conducted in the context of stakeholder participationand Eco-Logical, a planning process developed by FHWA to better integratetransportation and environmental planning. To understand whichstretches of SR-37 might be most vulnerable to SLR and to what degree, amodel of potential inundation was developed with a recent, high-resolutionelevation assessment conducted using lidar. This model projects potentialinundation by comparing future daily and extreme tide levels with surroundingground elevations. The vulnerability of each segment was scoredaccording to its exposure to SLR effects, sensitivity to SLR, and adaptivecapacity (ability of other roadways to absorb traffic). The risk to each segmentfrom SLR was determined by estimating and aggregating impacts tocosts of improvement, recovery time (from impacts), public safety impacts,economic impacts, impacts on transit routes, proximity to communitiesof concern, and impacts on recreational activities.

Highways provide commuter traffic and goods movement among regions and cities through wild, protected areas. Wildlife-vehicle collisions (WVC) can occur frequently when wildlife are present, impacting drivers and animals. Because collisions are often avoidable with constructed mitigation and reduced speeds, transportation agencies often want to know where they can act most effectively and what kinds of mitigation are cost-effective. For this study, WVC occurrences were obtained from two sources: 1) highway agencies that monitor carcass retrieval and disposal by agency maintenance staff and 2) opportunistic observations of carcasses by participants in two statewide systems, the California Roadkill Observation System (CROS; http://wildlifecrossing.net/california) and the Maine Audubon Wildlife Road Watch (MAWRW; http://wildlifecrossing.net/maine). Between September, 2009 and December 31, 2014, >33,700 independent observations of >450 vertebrate species had been recorded in these online, form-based informatics systems by >1,300 observers. We asked whether or not WVC observations collected by these extensive, volunteer-science networks could be used to inform transportation-mitigation planning. Cluster analyses of volunteer-observed WVC were performed using spatial autocorrelation tests for parts or all of 34 state highways and interstates. Statistically-significant WVC hotspots were modeled using the Getis- Ord Gi* statistic. High density locations of WVC, that were not necessarily hotspots, were also visualized. Statistically-significant hotspots were identified along ~7,900 km of highways. These hotspots are shown to vary in position from year to year. For highways with frequent deer-vehicle collisions, annual costs fromcollisions ranged from US$0 to >US$30,000/km. Carcass clusters from volunteer data had very little or no overlap with similar findings from agency-collected WVC data, during a different time-range. We show that both state agency-collected and volunteer-collection of WVC observations could be useful in prioritizing mitigation action at US state-scales by state transportation agencies to protect biodiversity and driver safety. Because of the spatial extent and taxonomic accuracy at which volunteer observations can be collected, these may be the most important source of data for transportation agencies to protect drivers and wildlife.

Context. The Public European Southern Observatory Spectroscopic Survey of Transient Objects (PESSTO) began as a public spectroscopic survey in April 2012. PESSTO classifies transients from publicly available sources and wide-field surveys, and selects science targets for detailed spectroscopic and photometric follow-up. PESSTO runs for nine months of the year, January - April and August - December inclusive, and typically has allocations of 10 nights per month. Aims. We describe the data reduction strategy and data products that are publicly available through the ESO archive as the Spectroscopic Survey data release 1 (SSDR1). Methods. PESSTO uses the New Technology Telescope with the instruments EFOSC2 and SOFI to provide optical and NIR spectroscopy and imaging. We target supernovae and optical transients brighter than 20.5m for classification. Science targets are selected for follow-up based on the PESSTO science goal of extending knowledge of the extremes of the supernova population. We use standard EFOSC2 set-ups providing spectra with resolutions of 13-18 Å between 3345-9995 Å. A subset of the brighter science targets are selected for SOFI spectroscopy with the blue and red grisms (0.935-2.53 μm and resolutions 23-33 Å) and imaging with broadband JHKs filters. Results. This first data release (SSDR1) contains flux calibrated spectra from the first year (April 2012-2013). A total of 221 confirmed supernovae were classified, and we released calibrated optical spectra and classifications publicly within 24 h of the data being taken (via WISeREP). The data in SSDR1 replace those released spectra. They have more reliable and quantifiable flux calibrations, correction for telluric absorption, and are made available in standard ESO Phase 3 formats. We estimate the absolute accuracy of the flux calibrations for EFOSC2 across the whole survey in SSDR1 to be typically ∼15%, although a number of spectra will have less reliable absolute flux calibration because of weather and slit losses. Acquisition images for each spectrum are available which, in principle, can allow the user to refine the absolute flux calibration. The standard NIR reduction process does not produce high accuracy absolute spectrophotometry but synthetic photometry with accompanying JHKs imaging can improve this. Whenever possible, reduced SOFI images are provided to allow this. Conclusions. Future data releases will focus on improving the automated flux calibration of the data products. The rapid turnaround between discovery and classification and access to reliable pipeline processed data products has allowed early science papers in the first few months of the survey.

We present optical observations of the peculiar stripped-envelope supernovae (SNe) LSQ12btw and LSQ13ccw discovered by the La Silla-QUEST survey. LSQ12btw reaches an absolute peak magnitude of Mg = -19.3 ± 0.2, and shows an asymmetric light curve. Stringent pre-discovery limits constrain its rise time to maximum light to less than 4 d, with a slower post-peak luminosity decline, similar to that experienced by the prototypical SN Ibn 2006jc. LSQ13ccw is somewhat different: while it also exhibits a very fast rise to maximum, it reaches a fainter absolute peak magnitude (Mg =-18.4 ± 0.2), and experiences an extremely rapid post-peak decline similar to that observed in the peculiar SN Ib 2002bj. A stringent pre-discovery limit and an early marginal detection of LSQ13ccw allow us to determine the explosion time with an uncertainty of ±1 d. The spectra of LSQ12btw show the typical narrow He I emission lines characterizing Type Ibn SNe, suggesting that the SN ejecta are interacting with He-rich circumstellar material. The He I lines in the spectra of LSQ13ccw exhibit weak narrow emissions superposed on broad components. An unresolved Ha line is also detected, suggesting a tentative Type Ibn/IIn classification. As for other SNe Ibn, we argue that LSQ12btw and LSQ13ccw likely result from the explosions of Wolf-Rayet stars that experienced instability phases prior to core collapse. We inspect the host galaxies of SNe Ibn, and we show that all of them but one are hosted in spiral galaxies, likely in environments spanning a wide metallicity range.

TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP

We present optical spectra and light curves for three hydrogen-poor superluminous supernovae followed by the Public ESO Spectroscopic Survey of Transient Objects (PESSTO). Time series spectroscopy from a fewdays aftermaximum light to 100 d later shows them to be fairly typical of this class, with spectra dominated by Ca II, MgII, FeII, and Si II, which evolve slowly over most of the post-peak photospheric phase. We determine bolometric light curves and apply simple fitting tools, based on the diffusion of energy input by magnetar spin-down, 56Ni decay, and collision of the ejecta with an opaque circumstellar shell. We investigate how the heterogeneous light curves of our sample (combined with others from the literature) can help to constrain the possible mechanisms behind these events. We have followed these events to beyond 100-200 d after peak, to disentangle host galaxy light from fading supernova flux and to differentiate between the models, which predict diverse behaviour at this phase. Models powered by radioactivity require unrealistic parameters to reproduce the observed light curves, as found by previous studies. Both magnetar heating and circumstellar interaction still appear to be viable candidates. A large diversity is emerging in observed tail-phase luminosities, with magnetar models failing in some cases to predict the rapid drop in flux. This would suggest either that magnetars are not responsible, or that the X-ray flux from the magnetar wind is not fully trapped. The light curve of one object shows a distinct rebrightening at around 100 d after maximum light. We argue that this could result either from multiple shells of circumstellar material, or from a magnetar ionization front breaking out of the ejecta.

We present photospheric-phase observations of LSQ12gdj, a slowly declining, UV-bright Type Ia supernova. Classified well before maximum light, LSQ12gdj has extinction-corrected absolute magnitude MB = -19.8, and pre-maximum spectroscopic evolution similar to SN 1991T and the super-Chandrasekhar-mass SN 2007if. We use ultraviolet photometry from Swift, ground-based optical photometry, and corrections from a near-infrared photometric template to construct the bolometric (1600-23 800 Å) light curve out to 45 d past B-band maximum light. We estimate that LSQ12gdj produced 0.96 ± 0.07 M· of 56Ni, with an ejected mass near or slightly above the Chandrasekhar mass. As much as 27 per cent of the flux at the earliest observed phases, and 17 per cent at maximum light, is emitted bluewards of 3300 Å. The absence of excess luminosity at late times, the cutoff of the spectral energy distribution bluewards of 3000 Å and the absence of narrow line emission and strong Na I D absorption all argue against a significant contribution from ongoing shock interaction. However, ~10 per cent of LSQ12gdj's luminosity near maximum light could be produced by the release of trapped radiation, including kinetic energy thermalized during a brief interaction with a compact, hydrogen-poor envelope (radius

Extragalactic fast X-ray transients (FXTs) are a class of soft (0.3–10 keV) X-ray transients lasting a few hundred seconds to several hours. Several progenitor mechanisms have been suggested to produce FXTs, including supernova shock breakouts, binary neutron star mergers, or tidal disruptions involving an intermediate-mass black hole and a white dwarf. We present detailed host studies, including spectroscopic observations of the host galaxies of seven XMM-Newton -discovered FXTs. The candidate hosts lie at redshifts 0.0928 < z < 0.645 implying peak X-ray luminosities of 1043 erg s−1< LX < 1045 erg s−1 and physical offsets of 1 kpc < r proj < 22 kpc. These observations increase the number of FXTs with a spectroscopic redshift measurement by a factor of 2, although we note that one event is re-identified as a Galactic flare star. We infer host star formation rates and stellar masses by fitting the combined spectroscopic and archival photometric data. We also report on a contemporaneous optical counterpart search to the FXTs in Pan-STARRS and ATLAS by performing forced photometry at the position of the FXTs. We do not find any counterpart in our search. Given our constraints, including peak X-ray luminosities, optical limits, and host properties, we find that XRT 110 621 is consistent with an supernova shock breakout (SN SBO) event. Spectroscopic redshifts of likely host galaxies for four events imply peak X-ray luminosities that are too high to be consistent with SN SBOs, but we are unable to discard either the binary neutron star or white dwarf–intermediate-mass black hole tidal disruption event scenarios for these FXTs. [ABSTRACT FROM AUTHOR]

A key tracer of the elusive progenitor systems of Type Ia supernovae (SNe Ia) is the detection of narrow blueshifted time-varying Na I D absorption lines, interpreted as evidence of circumstellar material surrounding the progenitor system. The origin of this material is controversial, but the simplest explanation is that it results from previous mass-loss in a system containing a white dwarf and a non-degenerate companion star. We present new singleepoch intermediate-resolution spectra of 17 low-redshift SNe Ia taken with XShooter on the European Southern Observatory Very Large Telescope. Combining this sample with events from the literature, we confirm an excess (~20 per cent) of SNe Ia displaying blueshifted narrow Na I D absorption features compared to redshifted Na I D features. The host galaxies of SNe Ia displaying blueshifted absorption profiles are skewed towards later-type galaxies, compared to SNe Ia that show no Na I D absorption and SNe Ia displaying blueshifted narrow Na I D absorption features have broader light curves. The strength of the Na I D absorption is stronger in SNe Ia displaying blueshifted Na I D absorption features than those without blueshifted features, and the strength of the blueshifted Na I D is correlated with the B - V colour of the SN at maximum light. This strongly suggests the absorbing material is local to the SN. In the context of the progenitor systems of SNe Ia, we discuss the significance of these findings and other recent observational evidence on the nature of SN Ia progenitors. We present a summary that suggests that there are at least two distinct populations of normal, cosmologically useful SNe Ia. © 2013 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society.

Abstract.--The eastern gray squirrel, Sciurus carolinensis (EGS) has been introduced to California and has expanded its geographic range since initial introductions. In this study we projected the potential future geographic [...]

This project included estimation of animal occurrence near and using structures (e.g., culverts, street, and RR crossing structures) to cross the Interstate-80 right-of-way in the Sierra Nevada, California. A combination of track plates near over-crossings and remote cameras at under-crossings was used to index wildlife occurrence and crossings. Diversity was relatively low in the highway right-of-way and at highway under-crossings. Across six highway under-crossings, only eight of 38 possible species were observed moving through these crossings from one side of the highway right-of-way to the other. Alpha diversity at highway crossings ranged widely for wildlife near street under and over-crossings, but was not related to nearby land development. Wildlife use of existing under-crossing structures was inversely proportional to the presence of humans and frequency of human use of the same structures. This has important implications for effectiveness of existing structures and purpose-built “wildlife crossings” to provide for wildlife movement.

The numerous effects roads have on the surrounding environment were investigated and geographically modeled. Several of these effects were then isolated and looked at in greater detail, developing a model that represents the various interactions between a road and the surrounding region. These road effects could be expressed in a GIS (geographic information system) environment, based on user-inputs. A traffic noise model was used to estimate the extent and intensity of this road effect. Environmental attributes were also summarized within the traffic noise effect zone as an example of evaluation of road effects useful during early transportation planning. The model was designed to be a proof-of-concept of a standalone tool for environmental and transportation planners in local and state agencies.

The global pandemic of COVID-19 has challenged the management of hypoxaemic respiratory failure and strained intensive care unit resources. While prone positioning (PP) is an established therapy in mechanically ventilated patients with acute respiratory distress syndrome (ARDS), its role in conscious patients is less well defined. We retrospectively reviewed our experience of implementing early PP in a cohort of 24 patients with acute hypoxaemic respiratory failure due to COVID-19 who required support with continuous positive airway pressure (CPAP). The use of PP alongside CPAP significantly increased both the ROX index and arterial oxygen pressure:fractional inspired oxygen (PaO2:FiO2) ratio from baseline values (ROX index: 7.0±2.5 baseline vs 11.4±3.7 CPAP+PP, p

The Safe Passages project is a collaborationbetween scientists at UC Davis and nongovernmentalconservation organizations(Defenders of Wildlife, Conservation BiologyInstitute, and South Coast Wildlands), inconsultation with state agencies (CaliforniaDepartments of Transportation and Fish andGame), and is intended to encourage theinclusion of habitat connectivity planning andprotection in local and regional planning insupport of the State Wildlife Action Plan. It wasdesigned to be a model effort, with relevance toregions struggling with finding ways to conservewildlife and natural processes in the face ofdevelopment. One major ecological process atrisk is isolation of wildlife populations andreduction of the permeability of the landscapeto wildlife movement. The project draws uponcontemporary scientific understanding ofwildlife movement, physical connections onlandscapes, and land‐use and transportationplanning in order to better fit developmentpatterns to the needs of natural processes,especially wildlife movement.As its name implies, the projectaddresses the need for finding safe passage forwildlife movement through the diverse regionsof California. Two philosophical choices weremade in designing this project: 1) wildlifemovement is not limited to managed reservesand corridors, but may also occur in the nonnaturallandscape matrix, and 2) that local andregional planners can become aware of and beincluded in the process of conservingconnectivity. In the first case, the computermodeling that was done in this project wasbased on the idea that wildlife might originatetheir movement from anywhere and move inthe least‐costly direction. This results in asurface of possible wildlife movement based onhabitat preference and barriers to safe passage.In the second case, planners in the San JoaquinValley Blueprint process learned of our overallproject goals and methods and a number ofcities or counties expressed interest in workingwith us. We chose the city of Riverbank, in partbecause the community development directorshowed clear interest in using the products ofour work in the General Planning and SpecificPlanning processes.This project has evolved to includemore ideas and potential partners, including theCalifornia Department of Fish and Game (DFG),the Local Government Commission, and otheracademic researchers. This evolution hasextended our project horizon indefinitely with acombination of a DFG contract andcollaborative proposal development. Howeverthe main project goal of setting the standard forhow connectivity can be included in local andregional planning has stayed constant. Ourpartners will help us develop a sea change inthe recognition and protection of safe passagesfor wildlife movement throughout California’sSan Joaquin Valley and beyond.