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44 results on '"Filippelli, Walter"'

18. The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation.

Author

Russomanno, Giusy, Corbi, Graziamaria, Manzo, Valentina, Ferrara, Nicola, Rengo, Giuseppe, Puca, Annibale A., Latte, Salvatore, Carrizzo, Albino, Calabrese, Maria Consiglia, Andriantsitohaina, Ramaroson, Filippelli, Walter, Vecchione, Carmine, Filippelli, Amelia, and Conti, Valeria

Subjects
CARDIAC rehabilitation, SIRTUINS, AGING prevention, HEART failure treatment, SUPEROXIDE dismutase
Abstract

Background: An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodynamic effects of CRP are well known, its underlying molecular mechanisms have not been fully clarified. The present study aims to evaluate the effects of a well-structured 4-week CRP in patients with stable HF from a molecular point of view. Results: A prospective longitudinal observational study was conducted on patients consecutively admitted to cardiac rehabilitation. In fifty elderly HF patients with preserved ejection fraction (HFpEF), levels of sirtuin 1 (Sirt1) in peripheral blood mononuclear cells (PBMCs) and of its targets, the antioxidants catalase (Cat) and superoxide dismutase (SOD) in serum were measured before (Patients, P) and at the end of the CRP (Rehabilitated Patients, RP), showing a rise of their activities after rehabilitation. Endothelial cells (ECs) were conditioned with serum from P and RP, and oxidative stress was induced using hydrogen peroxide. An increase of Sirt1 and Cat activity was detected in RP-conditioned ECs in both the absence and presence of oxidative stress, together with a decrease of senescence, an effect not observed during Sirt1 and Cat inhibition. Conclusions: In addition to the improvement in functional and hemodynamic parameters, a supervised exercisebased CRP increases Sirt1 activity and stimulates a systemic antioxidant defence in elderly HFpEF patients. Moreover, CRP produces antioxidant and anti-senescent effects in human endothelial cells mediated, at least in part, by Sirt1 and its target Cat. [ABSTRACT FROM AUTHOR]

Published
2017
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19. A Polymorphism at the Translation Start Site of the Vitamin D Receptor Gene Is Associated with the Response to Anti-Osteoporotic Therapy in Postmenopausal Women from Southern Italy.

Author

Conti, Valeria, Russomanno, Giusy, Corbi, Graziamaria, Toro, Giuseppe, Simeon, Vittorio, Filippelli, Walter, Ferrara, Nicola, Grimaldi, Michela, D'Argenio, Valeria, Maffulli, Nicola, and Filippelli, Amelia

Subjects
SINGLE nucleotide polymorphisms, VITAMIN D receptors, OSTEOPOROSIS in women, BONE density, DIPHOSPHONATES, THERAPEUTICS
Abstract

The present study investigated the effect of two single nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, rs1544410 A/G and rs2228570 C/T, in modulating bone mineral density (BMD) and the response to treatment with bisphosphonates or strontium ranelate in postmenopausal osteoporosis (PMO). Four hundred eighteen postmenopausal women from Southern Italy treated with bisphosphonates or strontium ranelate for three years were enrolled and stratified according to their genotype. Changes in BMD were expressed as the delta t-score (t-score). Allelic frequencies for rs1544410 A/GSNP were 11.2% AA, 50.0% GA and 38.8% GG; for rs2228570 C/TSNP were 54.8% CC, 39.5% TC and 5.7% TT. TT carriers showed a lower t-score than TC and CC (both p < 0.02) genotypes and were more responsive to the therapy when compared to both TC (p < 0.02) and CC (p < 0.05) carriers. Specifically, TT carriers receiving alendronate demonstrated a significant improvement of the t-score compared to TC and CC (both p < 0.0001) carriers. After adjustment for confounders, the t-score showed evidence of a statistically significant positive association with TT in all treatments considered. Therapy response was independent of rs1544410 A/G SNP; instead, rs2228570 C/TSNP was associated with a better response to antiresorptive treatment, thus suggesting that the therapy for PMO should be personalized. [ABSTRACT FROM AUTHOR]

Published
2015
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