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2. Docetaxel-Based Neoadjuvant Chemotherapy Followed by En Bloc Resection for Esophageal Adenocarcinoma: A 15-Year Retrospective Analysis from a Regional Upper Gastrointestinal Cancer Network

Author

Tankel, James, Ahmed, Nabeel, Mueller, Carmen, Najmeh, Sarah, Spicer, Jonathan, Mulder, David, Cool-Lartigue, Jonathan, Rousseau, Mathieu, Frechette, Dominique, Sud, Shelly, Kavan, Petr, Moghrabi, Albert, Champagne, Martin, Lemay, Frederic, Dalfen, Richard, Sirhan, Shireen, Asselah, Jamil, Alcindor, Thierry, and Ferri, Lorenzo

Published
2024
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3. Apposition of Fibroblasts With Metaplastic Gastric Cells Promotes Dysplastic Transition

Author

Lee, Su-Hyung, Panta, Ela W Contreras, Gibbs, David, Won, Yoonkyung, Min, Jimin, Zhang, Changqing, Roland, Joseph T, Hong, Se-Hoon, Sohn, Yoojin, Krystofiak, Evan, Jang, Bogun, Ferri, Lorenzo, Sangwan, Veena, Ragoussis, Jiannis, Camilleri-Broët, Sophie, Caruso, Joseph, Chen-Tanyolac, Chira, Strasser, Michael, Gascard, Philippe, Tlsty, Thea D, Huang, Sui, Choi, Eunyoung, and Goldenring, James R

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Clinical Research, Digestive Diseases, Cancer, Stomach Cancer, 2.1 Biological and endogenous factors, Humans, Gastric Mucosa, Stomach Neoplasms, Hyperplasia, Metaplasia, Fibroblasts, Gastric Carcinogenesis, SPEM, PDGFRA, Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsElements of field cancerization, including atrophic gastritis, metaplasia, and dysplasia, promote gastric cancer development in association with chronic inflammation. However, it remains unclear how stroma changes during carcinogenesis and how the stroma contributes to progression of gastric preneoplasia. Here we investigated heterogeneity of fibroblasts, one of the most important elements in the stroma, and their roles in neoplastic transformation of metaplasia.MethodsWe used single-cell transcriptomics to evaluate the cellular heterogeneity of mucosal cells from patients with gastric cancer. Tissue sections from the same cohort and tissue microarrays were used to identify the geographical distribution of distinct fibroblast subsets. We further evaluated the role of fibroblasts from pathologic mucosa in dysplastic progression of metaplastic cells using patient-derived metaplastic gastroids and fibroblasts.ResultsWe identified 4 subsets of fibroblasts within stromal cells defined by the differential expression of PDGFRA, FBLN2, ACTA2, or PDGFRB. Each subset was distributed distinctively throughout stomach tissues with different proportions at each pathologic stage. The PDGFRα+ subset expanded in metaplasia and cancer compared with normal, maintaining a close proximity with the epithelial compartment. Co-culture of metaplasia- or cancer-derived fibroblasts with gastroids showing the characteristics of spasmolytic polypeptide-expressing metaplasia-induced disordered growth, loss of metaplastic markers, and increases in markers of dysplasia. Culture of metaplastic gastroids with conditioned media from metaplasia- or cancer-derived fibroblasts also promoted dysplastic transition.ConclusionsThese findings indicate that fibroblast associations with metaplastic epithelial cells can facilitate direct transition of metaplastic spasmolytic polypeptide-expressing metaplasia cell lineages into dysplastic lineages.

Published
2023

5. Concerted epithelial and stromal changes during progression of Barrett’s Esophagus to invasive adenocarcinoma exposed by multi-scale, multi-omics analysis

Author

Strasser, Michael K, Gibbs, David L, Gascard, Philippe, Bons, Joanna, Hickey, John W, Schürch, Christian M, Tan, Yuqi, Black, Sarah, Chu, Pauline, Ozkan, Alican, Basisty, Nathan, Sangwan, Veena, Rose, Jacob, Shah, Samah, Camilleri-Broet, Sophie, Fiset, Pierre-Oliver, Bertos, Nicolas, Berube, Julie, Djambazian, Haig, Li, Rui, Oikonomopoulos, Spyridon, Fels-Elliott, Daffolyn Rachael, Vernovsky, Sarah, Shimshoni, Elee, Collyar, Deborah, Russell, Ann, Ragoussis, Ioannis, Stachler, Matthew, Goldenring, James R, McDonald, Stuart, Ingber, Donald E, Schilling, Birgit, Nolan, Garry P, Tlsty, Thea D, Huang, Sui, and Ferri, Lorenzo E

Subjects
Biomedical and Clinical Sciences, Engineering, Biomedical Engineering, Cancer, Biotechnology, Rare Diseases, Digestive Diseases, 2.1 Biological and endogenous factors
Abstract

Esophageal adenocarcinoma arises from Barrett's esophagus, a precancerous metaplastic replacement of squamous by columnar epithelium in response to chronic inflammation. Multi-omics profiling, integrating single-cell transcriptomics, extracellular matrix proteomics, tissue-mechanics and spatial proteomics of 64 samples from 12 patients' paths of progression from squamous epithelium through metaplasia, dysplasia to adenocarcinoma, revealed shared and patient-specific progression characteristics. The classic metaplastic replacement of epithelial cells was paralleled by metaplastic changes in stromal cells, ECM and tissue stiffness. Strikingly, this change in tissue state at metaplasia was already accompanied by appearance of fibroblasts with characteristics of carcinoma-associated fibroblasts and of an NK cell-associated immunosuppressive microenvironment. Thus, Barrett's esophagus progresses as a coordinated multi-component system, supporting treatment paradigms that go beyond targeting cancerous cells to incorporating stromal reprogramming.

Published
2023

6. Data‐independent acquisition and quantification of extracellular matrix from human lung in chronic inflammation‐associated carcinomas

Author

Bons, Joanna, Pan, Deng, Shah, Samah, Bai, Rosemary, Chen‐Tanyolac, Chira, Wang, Xianhong, Elliott, Daffolyn R Fels, Urisman, Anatoly, O'Broin, Amy, Basisty, Nathan, Rose, Jacob, Sangwan, Veena, Camilleri‐Broët, Sophie, Tankel, James, Gascard, Philippe, Ferri, Lorenzo, Tlsty, Thea D, and Schilling, Birgit

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Rare Diseases, Cancer, Biotechnology, Clinical Research, Minority Health, 2.1 Biological and endogenous factors, Humans, Proteomics, Extracellular Matrix, Lung, Carcinoma, Squamous Cell, Inflammation, Extracellular Matrix Proteins, data-independent acquisition, extracellular matrix, lung squamous cell carcinoma, quantification, serpins, Information and Computing Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Early events associated with chronic inflammation and cancer involve significant remodeling of the extracellular matrix (ECM), which greatly affects its composition and functional properties. Using lung squamous cell carcinoma (LSCC), a chronic inflammation-associated cancer (CIAC), we optimized a robust proteomic pipeline to discover potential biomarker signatures and protein changes specifically in the stroma. We combined ECM enrichment from fresh human tissues, data-independent acquisition (DIA) strategies, and stringent statistical processing to analyze "Tumor" and matched adjacent histologically normal ("Matched Normal") tissues from patients with LSCC. Overall, 1802 protein groups were quantified with at least two unique peptides, and 56% of those proteins were annotated as "extracellular." Confirming dramatic ECM remodeling during CIAC progression, 529 proteins were significantly altered in the "Tumor" compared to "Matched Normal" tissues. The signature was typified by a coordinated loss of basement membrane proteins and small leucine-rich proteins. The dramatic increase in the stromal levels of SERPINH1/heat shock protein 47, that was discovered using our ECM proteomic pipeline, was validated by immunohistochemistry (IHC) of "Tumor" and "Matched Normal" tissues, obtained from an independent cohort of LSCC patients. This integrated workflow provided novel insights into ECM remodeling during CIAC progression, and identified potential biomarker signatures and future therapeutic targets.

Published
2023

8. Feasibility Study Utilizing NanoString’s Digital Spatial Profiling (DSP) Technology for Characterizing the Immune Microenvironment in Barrett’s Esophagus Formalin-Fixed Paraffin-Embedded Tissues

Author

Qurat-ul-Ain, Frei, Nicola F, Khoshiwal, Amir M, Stougie, Pim, Odze, Robert, Camilleri-Broet, Sophie, Ferri, Lorenzo, Duits, Lucas C, Bergman, Jacques, and Stachler, Matthew D

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cancer, Biotechnology, Digestive Diseases, Clinical Research, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Barrett's esophagus, esophageal adenocarcinoma, tumor microenvironment, spatial transcriptomics, spatial proteomics, immune profiling, Barrett’s esophagus, Oncology and carcinogenesis
Abstract

Characterization of the Barrett's esophagus (BE) microenvironment in patients with a known progression status, to determine how it may influence BE progression to esophageal adenocarcinoma (EAC), has been understudied, hindering both the biological understanding of the progression and the development of novel diagnostics and therapies. This study's aim was to determine if a highly multiplex interrogation of the microenvironment can be performed on endoscopic formalin-fixed, paraffin-embedded (FFPE) samples, utilizing the NanoString GeoMx digital spatial profiling (GeoMx DSP) platform and if it can begin to identify the types of immune cells and pathways that may mediate the progression of BE. We performed a spatial proteomic analysis of 49 proteins expressed in the microenvironment and epithelial cells of FFPE endoscopic biopsies from patients with non-dysplastic BE (NDBE) who later progressed to high-grade dysplasia or EAC (n = 7) or from patients who, after at least 5 years follow-up, did not (n = 8). We then performed an RNA analysis of 1812 cancer-related transcripts on three endoscopic mucosal resections containing regions of BE, dysplasia, and EAC. Profiling with GeoMx DSP showed reasonable quality metrics and detected expected differences between epithelium and stroma. Several proteins were found to have an increased expression within NDBE biopsies from progressors compared to non-progressors, suggesting further studies are warranted.

Published
2023

11. Use of fluorescence imaging and indocyanine green for sentinel node mapping during gastric cancer surgery: Results of an intercontinental Delphi survey.

Author

Sherwinter, Danny, Boni, Luigi, Bouvet, Michael, Ferri, Lorenzo, Hyung, Woo, Ishizawa, Takeaki, Kaleya, Ronald, Kelly, Kaitlyn, Kokudo, Norihiro, Lanzarini, Enrique, Luyer, Misha, Mitsumori, Norio, Mueller, Carmen, Park, Doo, Ribero, Dario, Rosati, Riccardo, Ruurda, Jelle, Sosef, Meindert, Schneider-Koraith, Sylke, Spinoglio, Giuseppe, Strong, Vivian, Takahashi, Naoto, Takeuchi, Hiroya, Wijnhoven, Bas, Yang, Han-Kwang, Dip, Fernando, Lo Menzo, Emanuele, White, Kevin, and Rosenthal, Raul

Subjects
Humans, Indocyanine Green, Stomach Neoplasms, Sentinel Lymph Node Biopsy, Optical Imaging, Sentinel Lymph Node
Abstract

BACKGROUND: Understanding the extent of tumor spread to local lymph nodes is critical to managing early-stage gastric cancer. Recently, fluorescence imaging with indocyanine green has been used to identify and characterize sentinel lymph nodes during gastric cancer surgery, but no published guidelines exist. We sought to identify areas of consensus among international experts in the use of fluorescence imaging with indocyanine green for mapping sentinel lymph nodes during gastric-cancer surgery. METHODS: In this 2-round, online Delphi survey, 27 international experts voted on 79 statements pertaining to patient preparation and contraindications to fluorescence imaging with indocyanine green during gastric cancer surgery; indications; technical aspects; advantages/disadvantages and limitations; and training and research. Methodological steps were adopted during survey design to minimize bias. RESULTS: Consensus was reached on 61 of 79 statements, including giving single injections of indocyanine green into each of the 4 quadrants peritumorally, administering indocyanine green on the same day as surgery, injecting a total of 1 to 5 mL of 5 mg/mL indocyanine green, injecting endoscopically into submucosa, and repeating indocyanine green injections a second time if sentinel lymph node visualization remains inadequate. Consensus also was reached that fluorescence imaging with indocyanine green is an acceptable single-agent modality for sentinel lymph node identification and that the sentinel lymph node basin method is preferred. However, sentinel lymph node dissection should be limited to T1 gastric cancer and tumors ≤4 cm in diameter, and further research is necessary to optimize the technique and render fluorescence-guided sentinel lymph nodes dissection acceptable for routine clinical use. CONCLUSION: Although considerable consensus was achieved, further research is necessary before this technology should be used in routine practice.

Published
2022

12. Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

Author

Bons, Joanna, Pan, Deng, Shah, Samah, Bai, Rosemary, Chen-Tanyolac, Chira, Wang, Xianhong, Elliott, Daffolyn R Fels, Urisman, Anatoly, O’Broin, Amy, Basisty, Nathan, Rose, Jacob, Sangwan, Veena, Camilleri-Broët, Sophie, Tankel, James, Gascard, Philippe, Ferri, Lorenzo, Tlsty, Thea D, and Schilling, Birgit

Subjects
Clinical Research, Biotechnology, Cancer, Lung, 2.1 Biological and endogenous factors, Aetiology
Abstract

Abstract: Early events associated with chronic inflammation and cancer involve significant remodeling of the extracellular matrix (ECM), which greatly affects its composition and functional properties. Using lung squamous cell carcinoma (LSCC), a chronic inflammation-associated cancer (CIAC), we optimized a robust proteomic pipeline to discover potential biomarker signatures and protein changes specifically in the stroma. We combined ECM enrichment from fresh human tissues, data-independent acquisition strategies, and stringent statistical processing to analyze ‘Tumor’ and matched adjacent histologically normal (‘Matched Normal’) tissues from patients with LSCC. Overall, 1,802 protein groups were quantified with at least two unique peptides, and 56% of those proteins were annotated as ‘extracellular’. Confirming dramatic ECM remodeling during CIAC progression, 529 proteins were significantly altered in the ‘Tumor’ compared to ‘Matched Normal’ tissues. The signature was typified by a coordinated loss of basement membrane proteins and small leucine-rich proteins. The dramatic increase in the stromal levels of SERPINH1/heat shock protein 47, that was discovered using our ECM proteomic pipeline, was validated by immunohistochemistry (IHC) of ‘Tumor’ and ‘Matched Normal’ tissues, obtained from an independent cohort of LSCC patients. This integrated workflow provided novel insights into ECM remodeling during CIAC progression, and identified potential biomarker signatures and future therapeutic targets. Statement of significance of the study: The extracellular matrix (ECM) is a complex scaffolding network composed of glycoproteins, proteoglycans and collagens, which binds soluble factors and, most importantly, significantly impacts cell fate and function. Alterations of ECM homeostasis create a microenvironment promoting tumor formation and progression, therefore deciphering molecular details of aberrant ECM remodeling is essential. Here, we present a multi-laboratory and refined proteomic workflow, featuring i) the prospective collection of tumor and matched histologically normal tissues from patients with lung squamous cell carcinoma, ii) the enrichment for ECM proteins, and iii) subsequent label-free data-independent acquisition (DIA)-based quantification. DIA is a powerful strategy to comprehensively profile and quantify all detectable precursor ions contained in the biological samples, with high quantification accuracy and reproducibility. When combined with very stringent statistical cutoffs, this unbiased strategy succeeded in capturing robust and highly confident proteins changes associated with cancer, despite biological variability between individuals. This label-free quantification workflow provided the flexibility required for ongoing prospective studies. Discussions with clinicians, surgeons, pathologists, and cancer biologists represent an opportunity to interrogate the DIA digitalized maps of the samples for newly formulated questions and hypotheses, thus gaining insights into the continuum of the disease and opening the path to novel ECM-targeted therapies.

Published
2022

13. 970: DISCRETE FIBROBLAST SUBSETS NURTURE GASTRIC CARCINOGENESIS

Author

Lee, Su-Hyung, Panta, Ela W Contreras, Gibbs, David L, Won, Yoonkyung, Min, Jimin, Zhang, Changqing, Ferri, Lorenzo E, Sangwan, Veena, Ragoussis, Ioannis, Camilleri-Broet, Sophie, Caruso, Joseph, Strasser, Michael, Gascard, Philippe D, Huang, Sui, Tlsty, Thea D, Choi, Eunyoung, and Goldenring, James R

Subjects
Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Published
2022

14. Tu1165: THE IMMUNE CELL MICROENVIRONMENT IS DIFFERENTIALLY-ALTERED ACCORDING TO DIVERSE EPITHELIAL LANDSCAPES IN THE PROGRESSION TO CANCER IN BARRETT OESOPHAGUS

Author

Lin, Meng-Lay, Hickey, John W, Schürch, Christian M, Carlotti, Emanuela, Passman, Adam M, Hackett, Richard J, Devkumar, Shruthi, Evans, James A, Gascard, Philippe D, Tlsty, Thea D, Ferri, Lorenzo E, Nolan, Garry P, and McDonald, Stuart A

Subjects
Clinical Sciences, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Published
2022

17. Remoteness from urban centre does not affect gastric cancer outcomes with established care pathway to specialist centre

Author

Kammili, Anitha, Morency, Dominique, Cools-Lartigue, Jonathan, Ferri, Lorenzo E., and Mueller, Carmen L.

Subjects
Medical centers -- Location, Cancer patients -- Comparative analysis -- Care and treatment -- Demographic aspects, Rural population -- Comparative analysis -- Care and treatment, Stomach cancer -- Care and treatment -- Patient outcomes -- Demographic aspects, Urban population -- Comparative analysis -- Care and treatment, Health, Health care industry
Abstract

Background: Patients living in rural communities experience difficulty accessing specialized medical care. Rural patients with cancer present with more advanced disease, have reduced access to treatment and have poorer overall survival than urban patients. This study's aim was to evaluate outcomes of patients with gastric cancer living in rural and remote areas versus urban and suburban communities in the context of an established care corridor to a tertiary care centre. Methods: All patients treated for gastric cancer at the McGill University Health Centre during 2010-2018 were included. Travel, lodging and cancer care coordination were provided for patients from remote and rural areas and coordinated centrally by dedicated nurse navigators servicing these regions. Statistics Canada's remoteness index was used to categorize patients into a rural and remote group and an urban and suburban group. Results: A total of 274 patients were included. Compared with patients from urban and suburban areas, patients from rural and remote areas were younger and their clinical tumour stage was higher at presentation. The number of curative resections and palliative surgeries and rate of nonresection were comparable (p = 0.96). Overall, disease-free and progression-free survival were comparable between the groups, and having locally advanced cancer correlated with poorer survival (p < 0.001). Conclusion: Although patients with gastric cancer from rural and remote areas had more advanced disease at presentation, their treatment patterns and survival were comparable to those of patients from urbanized areas in the context of a publicly funded care corridor to a multidisciplinary specialist cancer centre. Equitable access to health care is necessary to diminish any preexisting disparities among patients with gastric cancer. Contexte: Les malades des communautés rurales ont de la difficulté à accéder à des soins médicaux spécialisés. Les personnes cancéreuses des milieux ruraux ont une maladie plus avancée, un accès moindre au traitement et une moins bonne survie globale comparativement aux malades des milieux urbains. Cette étude avait pour but de comparer les résultats chez les malades aux prises avec un cancer de l'estomac qui vivent en région rurale ou éloignée et chez ceux qui vivent en ville ou en banlieue dans le contexte d'un corridor de services dument affilié à un centre de soins tertiaires. Méthodes : Nous avons inclus tous les malades traités pour un cancer de l'estomac au Centre universitaire de santé McGill de 2010 à 2018. Les déplacements, l'hébergement et la coordination des traitements oncologiques étaient fournis aux patients de régions rurales et éloignées, sous la coordination centrale d'un personnel infirmier pivot attitré desservant ces régions. L'indice d'éloignement de Statistique Canada a servi à catégoriser les malades selon qu'ils appartenaient à un groupe de région rurale et éloignée ou à un groupe de région urbanisée. Résultats: En tout, 274 patients ont été inclus. Comparativement aux malades de la ville ou de la banlieue, les malades des régions rurales et éloignées étaient plus jeunes, et le stade clinique de leur tumeur était plus élevé au moment de consulter. Le nombre de résections à visée curative, de chirurgies palliatives et le taux de non-résection étaient comparables (p = 0,96). Globalement les groupes ont enregistré des taux comparables de survie sans maladie et de survie sans progression, et les cancers localement avancés étaient en corrélation avec une moins bonne survie (p < 0,001). Conclusion: Même si les malades aux prises avec un cancer de l'estomac provenant de régions rurales et éloignées avaient une maladie plus avancée au moment de consulter, leurs modalités thérapeutiques et leur survie ont été comparables à celles des malades de régions urbanisés dans le contexte d'un corridor de services financés à même les fonds publics donnant accès à un centre d'oncologie multidisciplinaire. Un accès équitable aux soins de santé est nécessaire pour réduire les disparités existantes entre les malades atteints d'un cancer de l'estomac., Approximately 20% of North Americans (70 million people) live in rural communities. (1-3) Among patients with cancer, residence in a rural area has been correlated with more advanced disease stage [...]

Published
2023
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18. The Mutographs biorepository: A unique genomic resource to study cancer around the world

Author

Perdomo, Sandra, Abedi-Ardekani, Behnoush, de Carvalho, Ana Carolina, Ferreiro-Iglesias, Aida, Gaborieau, Valérie, Cattiaux, Thomas, Renard, Hélène, Chopard, Priscilia, Carreira, Christine, Spanu, Andreea, Nikmanesh, Arash, Cardoso Penha, Ricardo Cortez, Antwi, Samuel O., Ashton-Prolla, Patricia, Canova, Cristina, Chitapanarux, Taned, Cox, Riley, Curado, Maria Paula, de Oliveira, José Carlos, Dzamalala, Charles, Fabianova, Elenora, Ferri, Lorenzo, Fitzgerald, Rebecca, Foretova, Lenka, Gallinger, Steven, Goldstein, Alisa M., Holcatova, Ivana, Huertas, Antonio, Janout, Vladimir, Jarmalaite, Sonata, Kaneva, Radka, Kowalski, Luiz Paulo, Kulis, Tomislav, Lagiou, Pagona, Lissowska, Jolanta, Malekzadeh, Reza, Mates, Dana, McCorrmack, Valerie, Menya, Diana, Mhatre, Sharayu, Mmbaga, Blandina Theophil, de Moricz, André, Nyirády, Péter, Ognjanovic, Miodrag, Papadopoulou, Kyriaki, Polesel, Jerry, Purdue, Mark P., Rascu, Stefan, Rebolho Batista, Lidia Maria, Reis, Rui Manuel, Ribeiro Pinto, Luis Felipe, Rodríguez-Urrego, Paula A., Sangkhathat, Surasak, Sangrajrang, Suleeporn, Shibata, Tatsuhiro, Stakhovsky, Eduard, Świątkowska, Beata, Vaccaro, Carlos, Vasconcelos de Podesta, Jose Roberto, Vasudev, Naveen S., Vilensky, Marta, Yeung, Jonathan, Zaridze, David, Zendehdel, Kazem, Scelo, Ghislaine, Chanudet, Estelle, Wang, Jingwei, Fitzgerald, Stephen, Latimer, Calli, Moody, Sarah, Humphreys, Laura, Alexandrov, Ludmil B., Stratton, Michael R., and Brennan, Paul

Published
2024
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19. Relation between mismatch repair status, chemoresponse, survival and anatomic location in gastroesophageal adenocarcinoma

Author

Evaristo, Gertruda, Katz, Amit, Ramirez-Garcialuna, José L., Issac, Marianne S.M., Sangwan, Veena, Thai, Duc-Vinh, Bertos, Nicholas, Guiot, Marie-Christine, Camilleri-Broët, Sophie, Marcus, Victoria, Mueller, Carmen, Cools-Lartigue, Jonathan, Fiset, Pierre O., and Ferri, Lorenzo E.

Subjects
Adenocarcinoma -- Care and treatment -- Patient outcomes, Chemotherapy -- Complications and side effects -- Patient outcomes, Cancer -- Chemotherapy, Health, Health care industry
Abstract

Background: It has recently been reported that mismatch repair (MMR) status and microsatellite instability (MSI) status in gastroesophageal carcinomas predict surgical, chemotherapeutic and immunotherapeutic outcomes; however, there is extensive variability in the reported incidence and clinical implications of MMR/MSI status in gastroesophaegal adenocarcinomas. We characterized a Canadian surgical patient cohort with respect to MMR status, clinicopathologic correlates and anatomic tumour location. Methods: We investigated MMR and BRAF V600E status of gastroesophaegal adenocarcinomas in patients who underwent gastrectomy or esophagectomy with extended (D2) lymphadenectomy at a single centre between 2011 and 2019. We correlated patterns of MMR expression in the overall cohort and in anatomic location-defined subgroups with treatment response and overall survival using multivariate analysis. Results: In all, 226 cases of gastroesophaegal adenocarcinoma (63 esophageal, 98 gastroesophageal junctional and 65 gastric) were included. The MMR-deficient (dMMR) immunophenotype was found in 28 tumours (12.3%) (15 junctional [15.3%], 13 gastric [20.0%] and none of the esophageal). The majority (25 [89%]) of dMMR cases showed MLH1/PMS2 loss without concurrent BRAF V600E mutation. Two MSH2/MSH6-deficient gastric tumours and 1 MSH6-deficient junctional tumour were detected. The pathologic response to preoperative chemotherapy was comparable in the dMMR and MMR-proficient (pMMR) cohorts. However, dMMR status was associated with significantly longer median overall survival than pMMR status (5.8 yr v. 2.4 yr, hazard ratio [HR] 1.91, 95% confidence interval [CI] 1.06-3.46), particularly in junctional tumours (4.6 yr v. 1.9 yr, HR 2.97, 95% CI 1.27-6.94). Conclusion: Our study shows that MMR status has at least prognostic value, which supports the need for biomarker testing in gastroesophageal adenocarcinomas, including junctional adenocarcinomas. This highlights the clinical significance of determining the MMR status in all adenocarcinomas of the upper gastrointestinal tract. Response to induction chemotherapy, however, was not influenced by MMR status. Contexte : Selon un récent rapport, le statut du système de réparation des mésappa-riements (MMR, pour mismatch repair) et de l'instabilité microsatellitaire (MSI, pour microsatellite instability) dans le cancer gastro-oesophagien permet de prédire l'issue des traitements (chirurgie, chimiothérapie et immunothérapie); or, on observe une importante variabilité quant à l'incidence rapportée et quant aux répercussions cliniques du statut MMR/MSI dans les adénocarcinomes gastro-oesophagiens. Auprès d'une cohorte de patients canadiens qui ont été opérés, nous avons recueilli le statut MMR, les corrélats clinicopathologiques et la localisation de la tumeur. Méthodes : Nous avons établi le statut MMR et BRAF V600E des adénocarcinomes gastro-oesophagiens chez des personnes ayant subi une gastrectomie ou une oesophagectomie avec lymphadénectomie étendue (D2) dans 1 seul centre entre 2011 et 2019. Nous avons établi la corrélation entre les modes d'expression du MMR dans la cohorte entière et dans des sous-groupes définis selon la localisation de la lésion, la réponse au traitement et la survie globale, à l'aide d'analyses multivariées. Résultats : En tout, nous avons inclus 226 cas d'adénocarcinomes gastro-oesophagiens (63 de l'oesophage, 98 de la jonction gastro-oesophagienne et 65 de l'estomac). L'immunophénotype MMR-déficient (dMMR) a été observé dans 28 tumeurs (12,3 %) (15 de la jonction [15,3 %], 13 de l'estomac [20,0 %] et aucun de l'oesophage). La majorité (25 [89 %]) des cas dMMR étaient négatifs pour MLH1/PMS2, sans mutation BRAF V600E concomitante. Deux tumeurs gastriques négatives pour MSH2/MSH6 et 1 tumeur de la jonction négative pour MSH6 ont été détectées. La réponse anatomo-pathologique à la chimiothérapie préopératoire a été comparable dans les cohortes dMMR et MMR-compétentes (pMMR). Toutefois, le statut dMMR a été associé à une survie médiane globale significativement plus longue que le statut pMMR (5,8 ans c. 2,4 ans, risque relatif [RR] 1,91, intervalle de confiance [IC] de 95 % 1,06-3,46), particulièrement pour les tumeurs de la jonction (4,6 ans c. 1,9 an, RR 2,97, IC de 95 % 1,27-6,94). Conclusion : Selon notre étude, le statut MMR a la moins grande valeur pronostique, ce qui appuie le recours à un dosage des biomarqueurs pour les adénocarcinomes gastro-oesophagiens, y compris les adénocarcinomes de la jonction gastrooesophagienne. Cela rappelle l'importance au plan clinique de déterminer le statut MMR dans tous cas d'adénocarcinome des voies digestives hautes. La réponse à la chimiothérapie d'induction n'a toutefois subi aucune influence du statut MMR., Upper gastrointestinal malignant diseases represent close to 9% of all new cancer cases and 14% of all cancer deaths worldwide. (1) Of their 2 main histologic subtypes, squamous cell carcinoma [...]

Published
2023

26. Delayed Surgical Intervention After Chemoradiotherapy in Esophageal Cancer: (DICE) Study

Author

Chidambaram, Swathikan, Owen, Richard, Sgromo, Bruno, Chmura, Magdalena, Kisiel, Aaron, Evans, Richard, Griffiths, Ewen A., Castoro, Carlo, Gronnier, Caroline, MaoAwyes, Mometo Ali, Gutschow, Christian A., Piessen, Guillaume, Degisors, Sébastien, Alvieri, Rita, Feldman, Hope, Capovilla, Giovanni, Grimminger, Peter P., Han, Shiwei, Low, Donald E., Moore, Jonathan, Gossage, James, Voeten, Dan, Gisbertz, Suzanne S., Ruurda, Jelle, van Hillegersberg, Richard, D’Journo, Xavier B., Chmelo, Jakub, Phillips, Alexander W., Rosati, Riccardo, Hanna, George B., Maynard, Nick, Hofstetter, Wayne, Ferri, Lorenzo, Berge Henegouwen, Mark I., and Markar, Sheraz R.

Published
2023
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32. Factors Associated With Advanced Histological Diagnosis and Upstaging After Endoscopic Submucosal Dissection of Superficial Gastric Neoplasia

Author

Gudenkauf, Franciska J., Mehta, Amit, Ferri, Lorenzo, Aihara, Hiroyuki, Draganov, Peter V., Yang, Dennis J., Jue, Terry L., Munroe, Craig A., Boparai, Eshandeep S., Mehta, Neal A., Bhatt, Amit, Kumta, Nikhil A., Othman, Mohamed O., Mercado, Michael, Javaid, Huma, Aadam, Abdul Aziz, Siegel, Amanda, James, Theodore W., Grimm, Ian S., DeWitt, John M., Novikov, Aleksey, Schlachterman, Alexander, Kowalski, Thomas, Samarasena, Jason, Hashimoto, Rintaro, Chehade, Nabil El Hage, Lee, John G., Chang, Kenneth, Su, Bailey, Ujiki, Michael B., Sharaiha, Reem Z., Carr-Locke, David L., Chen, Alex, Chen, Michael, Chen, Yen-I, Tomizawa, Yutaka, von Renteln, Daniel, Kumbhari, Vivek, Khashab, Mouen A., Bechara, Robert, Karasik, Michael, Patel, Neej J., Fukami, Norio, Nishimura, Makoto, Hanada, Yuri, Song, Louis M. Wong Kee, Laszkowska, Monika, Wang, Andrew Y., Hwang, Joo Ha, Friedland, Shai, Sethi, Amrita, and Ngamruengphong, Saowanee

Published
2023
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37. Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

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Knight, Stephen R, Shaw, Catherine A, Pius, Riinu, Drake, Thomas M, Norman, Lisa, Ademuyiwa, Adesoji O, Adisa, Adewale O, Aguilera, Maria Lorena, Al-Saqqa, Sara W, Al-Slaibi, Ibrahim, Bhangu, Aneel, Biccard, Bruce M, Brocklehurst, Peter, Costas-Chavarri, Ainhoa, Chu, Kathryn, Dare, Anna, Elhadi, Muhammed, Fairfield, Cameron J, Fitzgerald, J Edward, Ghosh, Dhruv, Glasbey, James, van Berge Henegouwen, Mark I., Ingabire, J.C. Allen, Kingham, T Peter, Lapitan, Marie Carmela, Lawani, Ismaïl, Lieske, Bettina, Lilford, Richard, Martin, Janet, McLean, Kenneth A, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pinkney, Thomas, Qureshi, Ahmad Uzair, Ramos-De la Medina, Antonio, Riad, Aya, Salem, Hosni Khairy, Simões, Joana, Spence, Richard, Smart, Neil, Tabiri, Stephen, Thomas, Hannah, Weiser, Thomas G, West, Malcolm, Whitaker, John, Harrison, Ewen M, Gjata, Arben, Modolo, Maria Marta, King, Sebastian, Chan, Erick, Nahar, Sayeda Nazmun, Waterman, Ade, Vervoort, Dominique, Bedada, Alemayehu Ginbo, De Azevedo, Bernardo, Figueiredo, Ana Gabriela, Sokolov, Manol, Barendegere, Venerand, Ekwen, Gerald, Agarwal, Arnav, Liu, Qinyang, Camilo Correa, Juan, Malemo, Kalisya Luc, Bake, Jacques, Mihanovic, Jakov, Kunčarová, Kamila, Orhalmi, Julius, Salem, Hosni, Teras, Jyri, Kechagias, Aristotelis, Arnaud, Alexis P, Lindert, Judith, Kalles, Vasileios, Aguilera-Arevalo, Maria-Lorena, Recinos, Gustavo, Baranyai, Zsolt, Kumar, Basant, Neelamraju Lakshmi, Harish, Zachariah, Sanoop Koshy, Alexander, Philip, Kumar Venkatappa, Sunil, Pramesh, C, Amandito, Radhian, Fleming, Christina, Ansaloni, Luca, Pellino, Gianluca, Altibi, Ahmed M., Nour, Ibrahim, Hamdun, Intisar, Ghellai, Ali M., Venskutonis, Donatas, Poskus, Tomas, Zilinskas, Justas, Malemia, Precious, Tew, Yong Yong, Borg, Elaine, Ellul, Sarah, Wafqui, fatima Zahraa, Borowski, David W, van Dalen, Anne Sophie, Wells, Cameron, Adamou, Harissou, Ademuyiwa, Adesoji, Adisa, Adewale, Søreide, Kjetil, Al Saqqa, Sara, Alser, Osaid, Tahboub, Haya, Segovia Lohse, Helmut Alfredo, Shu Yip, Sebastian, Major, Piotr, Sampaio Soares, António, Bratu, Matei Razvan, Litvin, Andrey, Vardanyan, Armen, Allen Ingabire, JC, Gudal, Ahmad, Albati, Naif, Juloski, Jovan, Rems, Miran, Rayne, Sarah, Van Straten, Stephanie, Moodley, Yoshan, Ortega Vázquez, Irene, Ruiz-Tovar, Jaime, Senanayake, Kithsiri Janakantha, Thalgaspitiya, Sujeewa Priyantha Bandara, Omer, Omer Abdelbagi, Homeida, Anmar, Cengiz, Yucel, Clerc, Daniel, Alshaar, Muhammad, Bouaziz, Hanen, Altinel, Yuksel, Doe, Matthew, Freigofer, Maryna, Teasdale, Ella, Kabariti, Rakan, Clements, Joshua Michael, Knight, Stephen Richard, Ashfaq, Ahsan, Azodo, Ijeoma, Wagner, Gabriela, Trostchansky, Ivan, Maimbo, Mayaba, Linyama, David, Nina, Helidon, Zeko, Amanda, Fermani, Claudio Gabriel, Villalobos, Santiago, Carballo, Federico, Farina, Pablo, Guckenheimer, Sebastian, Dickfos, Marilla, Ajmera, Ankit, Chong, Chester, Gourlay, Ralph, Hussaini, Sikandar, Lee, Yi Jia, Majid, Adeeb, Martin, Peter, Miles, Rebecca, Morris, Owen James, Phua, Jamie, Ridley, William, Saluja, Tarunpreet, Tan, Ryan Renxin, Teh, Jen, Wells, Anna, Arora, Bharti, Dollie, Qaasim, Ho, Debbie, Ma, Yanru, Perera, Omattage Mahasha, Truong, Anthony, Dawson, Amanda Caroline, Lim, Bryan, Pahalawatta, Upuli, Phan, Jacqueline, Woon-Shoo-Tong, Xiao-Ming Sarah, Yeoh, Andrea, Charman, Lillian, Drane, Andrew, Laura, Sharon, Lo, Charmaine Chu Wen, Mozes, Amy, Poon, Rita, Tan, Hao Han, Wall, Ellen, Chopra, Prakshi, De Giovanni, Jasmine, Dhital, Bal, Draganic, Brian, Duller, Alexander, Gani, Jonathan, Goh, Yao Kuan, Jeong, Jun Young, McManus, Brendan, Nagappan, Prakash, Pockney, Peter, Rugendyke, Anya, Sarrami, Mahsa, Smith, Stephen, Wills, Vanessa, Wong, Hsu Ven, Ye, Geoffrey, Zhang, Geoffrey, Brooker, Ethan, Feng, Daniel, Lau, Bonnie, Ngai, Carlin, Birks, Sarah, Gyorki, David, Otero de Pablos, Jaime, Abbosh, Ali, Gillespie, Chris, Mahmoud, Ahmed, Kwan, Bianca, Lawson, Joshua, Warwick, Andrea, Bingham, Janne, Cockbain, Andrew J, Dudi-Venkata, Nagendra Naidu, Ellaby-Hall, Jordan, Finlay, Ben, Humphries, Emily, Pisaniello, Jade, Pisaniello, Monique, Salih, Salma, Sammour, Tarik, Abd Wahab, Haidar Hadri, De Silva, April, Hayward, Nicola, Iyer, Kartik, Maddern, Guy, Prevost, Gian Andrea, Annapureddy, Naga, Settipalli, Krishna Pranathi, Yeo, Jeremy, Hempenstall, Lucy, Pham, Lily, Purcell, Shaun, Talavera, Cherry, Vaska, Ashish I, Chaggar, Gurpreet, Chrapko, Phillip, Cocco, Annelise, Coulter-Nile, Sarah Michelle Crystal Jade, Ctercteko, Grahame, French, James, Gong, Houchen, Gosselink, Martijn, Jegathees, Thuvarahan, Jin, Ivan, Kalachov, Michelle, Kiefhaber, Kathryn, Lee, Katherine, Luong, Jason, Phan, Steven, Pleass, Henry, Veale, Kelly, Zeng, Zhi, Au, Angela, DeBiasio, Ashe, Deng, Idy, Myooran, Jananee, Nair, Amrita, Stewart, Peter, Stift, Anton, Unger, Lukas Walter, Wimmer, Kerstin, Ahmed, Nabila, Hasan, Syed, Rahman, Saber, O'Shea, Margaret, Padmore, Greg, Peters, Adrian, Perduca, Pietro, Pulcina, Guenda, Tinton, Nicolas, Buxant, Frederic, Dabin, Elsa, Garofalo, Giulia, Dossou, Francis, Gnangnon, Freddy Houehanou Rodrigue, Imorou Souaibou, Yacoubou, Motlaleselelo, Pako, Tlhomelang, Omphile, Lima Buarque, Igor, Mendonça Ataíde Gomes, Gustavo, Vieira Barros, Aldo, Batashki, Ilia, Damianov, Nikolai, Stoyanov, Vladislav, Dardanov, Dragomir, Maslyankov, Svilen, Petkov, Plamen, Todorov, George, Zhivkov, Evgeni, Akisheva, Aygulya, Castilla Moreno, Miguel Angel, Genov, Geno, Ilieva, Ivelina, Ivanov, Tsvetomir, Karamanliev, Martin, Khan, Azhar, Mitkov, Emil, Yotsov, Tsanko, Atanasov, Boyko, Belev, Nikolay, Slavchev, Mihail, Nsengiyumva, Carlos, Jones, Elgan, Stock, Simon, Kyota, Steve, Brown, James, Mabanza K., Tresor, Nigo Samuel, Lemery, Otuneme, Chidi, Prosper, Ngwang, Umenze, Franklin, Boutros, Marylise, Caminsky, Natasha, Dumitra, Sinziana, Garfinkle, Richard, Morency, Dominique, Salama, Ebram, Banks, Alexander, Ferri, Lorenzo, He, Haitian, Katz, Amit, Liberman, Alexander Sender, Meterissian, Sarkis, Pang, Allison, Parvez, Elena, Hameed, Usmaan, Osman, Fahima, Sequeira, Sangita, Coburn, Natalie, Jaffer, Alisha, Karanicolas, Paul, Mosseler, Matthew, Musselman, Reilly, Liu, Xinyuan, Yip, Ching Wan, Garces-Otero, Juan Sebastian, Guzman, Carolina, Sierra, Sebastian, Uribe Valencia, Andres, Cabrera Rivera, Paulo Andrés, Camelo, Saul, Gonzalez, Andrea, González-Orozco, Alejandro, Mosquera Paz, Manuel Santiago, Perez Rivera, Carlos J, Gonzalez, Felipe, Isaza-Restrepo, Andres, Nino- Torres, Laura, Arias Madrid, Natalia, Mendoza Arango, Maria Clara, Tsandiraki, Justin, Jemendžić, Damir, Kocman, Branislav, Šuman, Oliver, Canic, Renata, Jurišić, Darko, Karakas, Ivana, Krizanovic Rupcic, Ana, Pitlovic, Vlatka, Samardžić, Josip, Kopljar, Mario, Bacic, Ivan, Domini, Edgar, Karlo, Robert, Miljanić, Danijela, Simic, Andrea, Ahmed, Mariam, Al Nassrallah, Majdi, Altaf, Rabiya, Amjad, Talal, Eltoum, Ruba, Haidar, Heba, Hassan, Alhassan, Khalil, Omar, Qasem, Marwan, Ramesh, Rommel, Sajith, Gautham, Wisal, Maham, Žatecký, Jan, Bujda, Michele, Jirankova, Katerina, Paclik, Ales, Abdallah, Aya, Abdulgawad Almogy, Mariam, Ayman El-sawy, Esraa, ElFayoumy, Ahmed Moustafa, Elghareeb, Nourhan, Esmat, Nourhan Ahmed, Fadel, Ahmed, Habater, Abdullah, Hamdy, Heba, Hefni, Amr, Kamal, Marwa, Mohamed Abobakr, Norhan, Sayed, Ahmed, Shaker, Nancy, Taha, Ehab, Tharwat, Hoda, Zakaria, Omar, Abdelmotaleb, Ibrahem, Al-Dhufri, Ali, Al-Himyari, Hamza S., El sheikh, Enas, Eldmaty, Asmaa, Elkhalawy, Aya, M.Elkhashen, Ahmed, Magdy, Kithara, Mostafa, Safa, Sadia, Habib Doutoum, Saleh, Mohamed mahmoud, Samir, Dina, Yahia Mohamed Ali, Mohamed, A. 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Reda Loaloa, Mohamed, Refaat, Ahmed, Samir, Hadeer, Shahien, Fatma, Sobhy, Mohamed, Sroor, Fathy, Abdellatif, Esraa, Adel, Marina, Afifi, Amr Abdelghani, Afifi, Eman, Antaky, Marco, Dawoud, Amr, El Zoghby, Naira, El-remaily, Amira, Elzanfaly, Ali Abdelazez, Gadallah, Ahmed, Gamal, Fatma Alzahraa, Hashem, Omar, Medhat Youssef, Shrouk, Muhammad Attyah, Aliaa, Munir, Malak, Shazly, Omar, Taha, Esraa, Wilson, Karim, Adel, Sawsan, Ali, Asmaa, Eid, Esraa, Elhelow, Esraa, Elmahdy, Marwa, Elshatby, Bassant, Hossam el-din Zakaria, Amany, Hossny, Ahmad, Ibrahim, Eman, M.Yonis, Ahmed, Metwalli, Maram, Yousry, Basant, Zid, Esraa, A Yacoub, Mina, Abdelhakim, Ahmed, Abouelsoad, Nervana, Alkhatib, Mo'min, Ashraf, Ahmed, Ashraf, Alaa, Elazab, Yasmin, Elfanty, Mahmoud, Elkabir, Osama, Elsayed, Mai, Elshimy, Ahmed, Elsobky, Hager, Eskander, John, Gad, Ahmed, Hamsho, Ward, Khaled Abdelwahed, Noura, Magdy, Menna, Moharam, Dalia, Osama, Abeer, Ramadan, Shereen, Roum, Radwa, Sayed, Taqwa, Shehada, Tarneem, Zidan, Ahmed Mohy, Abbas, Khalid, Ali, Amr, Attia, Mohamed, Balata, Mohamed, El Nakeeb, Ayman, Elewaily, Mohamed Ibrahim Elsayed, Elfallal, Ahmed, Elfeki, Hossam, Elkhadragy, Ahmed, Emile, Sameh, Ezzat, Helmy, Hosni, Hasnaa, Mansour, Islam, Omar, Waleed, Othman, Gehad, Sadek, Kareem, Shalaby, Mostafa, Shehab-Eldeen, Noura, Anas khalifa, Rawda, Badr, Helmy, Eldeep, Mostafa, Eldeep, Ahmed, Eldoseuky mohammed, Amany, Khallaf, Salwa, Magdy Hegazy, Eman, Mahmoud, Rokia, Mikhail, Pola, Morsi, Mahmoud, Mowafy, Sara, Raafat, Dina, Safy, Amina, Sera, Marwa, Sera, Ahmed shible, AbdAllah, Mostafa Salim Mohamed, Abdelkader, Muhammad, Abdou, Abdulrahman Osama, Ahmed, Ahmedgaber, Gaafar, Shireen, Ibrahim negm, Fatma, Lapic, Mina, Maher, Ahmed, Mahmoud, Hagar, Mostafa, Ahmed, Samir, Mohamed, Samy, Fatma, Semeda, Nourhan, Shalaby, Hind I., El-taweel, Alaa, Galal Elnagar, Ahmed, Hemidan, Ahmed Gamal, Hussein, Mohamed, Kandil, Ahmed.A., Moawad, Mf, Nasser Hamamah, Ayat Allah, Soliman, Mostafa, Abdelkhalek, Mohamed, Abdelmaksoud Tawakel, Noura, Abdelwahed, Ahmed Mohamed, Abdou, Alrawy, Atallah, Khalid, Elsherbeny, Mohammed Yasser, Emara, Eman, Hamdy, Mohamed, Hamdy, Omar, Haron, Amira, Ismail, Salma, Metwally, Islam Hany, Mohamed Hamed Elgaml, Nihal, Nassar, Ahmed, Refky, Basel, Sadek, Mirna, Saleh, Mahmoud, Yunes, Asmaa, Zakaria, Mai, Zuhdy, Mohammed, Fayed, Notila, Mohammed, Mohammed Mustafa Hassan, Kütner, Sander, Melnik, Priit, Seire, Indrek, Ümarik, Toomas, Ainoa, Eppu, Eerola, Verner, Koppatz, Hanna, Koskenvuo, Laura, Sallinen, Ville, Takala, Sini, Katunin, Jevgeni, Turunen, Arto, Christou, Niki, Mathonnet, Muriel, Lavoue, Vincent, Nyangoh Timoh, Krystel, Soulabaille, Lucie, Lesourd, Romain, Merdrignac, Aude, Sulpice, Laurent, André, Benoît, Chantalat, Elodie, Vaysse, Charlotte, Dousset, Bertrand, Gaujoux, Sebastien, Martin, Gregory, Clonda, Octavian, Juodis, Domantas, Kienle, Klaus, Mravik, Andras, Palmer, Samuel, Szabadhegyi, Gabor, Agbeko, Anita Eseenam, Gyabaah, Solomon, Gyamfi, Frank Enoch, Naabo, Nuhu, Owusu senior, Atta, Yorke, Joseph, Owusu, Frank, Abantanga, Francis, Anyomih, Theophilus Teddy Kojo, Muntaka, Abdul-Jalilu Mohammed, Owusu Abem, Emmanuel, Sheriff, Mohammed, Wondoh, Paul M., Balalis, Dimitrios, Korkolis, Dimitrios, Gkiokas, Georgios, Pantiora, Eirini, Theodosopoulos, Theodosios, Ioannidis, Argyrios, Konstantinidis, Konstantinos, Konstantinidou, Sofia, Machairas, Nikolaos, Paspala, Anna, Prodromidou, Anastasia, Chouliaras, Christos, Papadopoulos, Konstantinos, Baloyiannis, Ioannis, Mamaloudis, Ioannis, Tzovaras, George, Akrida, Ioanna, Argentou, Maria-Ioanna, Germanos, Stylianos, Iliopoulos, Evangelos, Maroulis, Ioannis, Skroubis, George, Theofanis, George, Chatzakis, Christos, Ioannidis, Orestis, Loutzidou, Lydia, Karathanasis, Panagiotis, Michalopoulos, Nikolaos, Theodoropoulos, Charalampos, Theodorou, Dimitrios, Triantafyllou, Tania, Garoufalia, Zoe, Hasemaki, Natasha, Kontos, Michalis, Kouraklis, Gregory, Kykalos, Stylianos, Liakakos, Theodore, Mpaili, Eustratia, Papalampros, Alexandros, Schizas, Dimitrios, Syllaios, Athanasios, Tampaki, Ekaterini Christina, Tsimpoukelis, Antonios, Antonopoulou, Maria Ioanna, Deskou, Eirini, Manatakis, Dimitrios K., Papageorgiou, Dimitrios, Zoulamoglou, Menelaos, Anthoulakis, Christos, Margaritis, Michalis, Nikoloudis, Nikolaos, Campo, Veronica, Ceballos, André, Flores, Mario-Andrés, Giron, Waleska, Ko, Donghyun, Martinez, Gabriel, Rivera Lara, Verónica, Rueda, Nataly, Sanchez, Andres, Tejeda Garrido, Jorge Carlos Guillermo, Alvarez Rivera, Alvaro Eduardo, Bamaca Ixcajoc, Elvis Benjamin, Barreda Zelaya, Lilian Elizabeth, Chacòn-Herrera, Patricia, Corea Ruiz, Ligia Margarita, Echeverria-Davila, Guillermo, Garcia, Mario, García, Danilo, Gutiérrez Mayen, Edgar Fernando, José, Noriega, Mazariegos, Nery, Méndez, Diego, Paniagua Espinoza, Michael, Bardos, David, Benke, Marton, Illes, Kristof, Kokas, Balint András, Szabó, Réka, Appukuttan, Akhila, Asok, Anjitha, D.k, Vijaykumar, Malik, Kapil, Ravishankaran, Praveen, Tapkire, Ritesh, Moorthy, Guru, Abraham, Joyner, Muthuvel, Ramesh, Alapatt, John, Kattepur, Abhay, Pareekutty, Nizamudheen, Garod, Mebanshanbor, Harris, Caleb, Wanniang, Cliff, Gupta, Ashish, Nehra, Deepak, Parshad, Sanjeev, Acharya, Rajgopal, Badwe, Rajendra, Bhandare, Manish, Jain, Urvashi, Kirti, Karishma, Nair, Nita, Shrikhande, Shailesh, Thakkar, Purvi, Anandan, Premkumar, C S, Archana, Holenarasipur Narasannaiah, Arun, Jagarlamudi, Tejaswi, M R, Rashmi, Manangi, Mallikarjuna, Raghavendra, Abhishek, Rao, K. Seshagiri, S, Vinay, Sajjan, Vinay, Shenoy, Aneesh, Shivashankar Chikkanayakanahalli, Santhosh, Tharanath, Kavya, V, Sushmita, Adidharma, Peter, Agarwal, Raksheeth, Anggita Gultom, Phebe, Arifin, Ghafur Rasyid, Billy, Matthew, Elfizri, Zatira, Fahira, Alessa, Felicia, Devi, Gunardi, Triana Hardianti, Johanna, Nadya, Nugrahadi, Nadia Rahmadiani, Panigoro, Sonar Soni, Rahmayanti, Siti, Sihotang, Retta Catherina, Brata, Santi Yuanita, Winoto, Hadi, Barati, Nastaran, Karami, Manoochehr, Khorshidi, Hamidreza, Naderifar, Homa, Abdulla, Mazin A., Coleman, Maggie, Doherty, Ronan J, Hannon, Rob, Murphy, Brenda, Stakelum, Aine, Winter, Des, Aljohmani, Lylas, Farnan, Richard, Seldon, Yeshey, Tan, Tanna, Varghese, Shriya, Alherz, Mohammad, Ather, Muaaz, Bajilan, Mohammad, Graziadei, Vivien, Pilkington, Isobel, Quidwai, Omar, Ridgway, Paul, Shiwani, Haaris, Tahir, Abd al-Rahman, Blunnie, Eimear, Burke, Daniel, Kennedy, Niall, Macdonagh, Kate, O'Neill, Maeve, Rooney, Siobhan, Falco, Giuseppe, Ferrari, Guglielmo, Mele, Simone, Nita, Gabriela Elisa, Ugoletti, Lara, Zizzo, Maurizio, Confalonieri, Gianmaria, Pesenti, Giovanni, Tagliabue, Fulvio, Baronio, Gianluca, Ongaro, Deborah, Pata, Giacomo, Compagnoni, Bruno, Salvadori, Renato, Taglietti, Lucio, D'Alessandro, Nicola, Di Lascio, Pierpaolo, Pascale, Giovanni, Bortolasi, Luca, Campagnaro, Tommaso, Carlini, Massimo, Lisi, Giorgio, Lombardi, Davide, Pedrazzani, Corrado, Spoletini, Domenico, Turri, Giulia, Violi, Paola, Altomare, Donato Francesco, Aquilino, Fabrizio, Musa, Nicola, Papagni, Vincenzo, Picciariello, Arcangelo, Vincenti, Leonardo, Andreotti, Dario, Occhionorelli, Savino, Tondo, Matteo, Basso, Stefano Maria Massimiliano., Ubiali, Paolo, Cirelli, Riccardo, Maino, Marco Enrico Mario, Piozzi, Guglielmo Niccolò, Picone, Emanuele, Scaramuzzo, Rosa, Sinibaldi, Giovanni, Amendola, Alfonso, Anastasio, Lorenzo, Bucci, Luigi, Caruso, Emanuele, Castaldi, Antonio, Di Maso, Sara, Dinuzzi, Vincenza Paola, Esposito, Giovanni, Gaudiello, Maria, Giglio, Mariano Cesare, Greco, Paola Antonella, Luglio, Gaetano, Manfreda, Andrea, Marra, Ester, Mastella, Federica, Pagano, Gianluca, Peltrini, Roberto, Pepe, Vincenzo, Sacco, Michele, Sollazzo, Viviana, Spiezio, Giovanni, Cianchetti, Ettore, Menduni, Nunzia, Carvello, Michele Maria, Di Candido, Francesca, Spinelli, Antonino, Corsi, Fabio, Sorrentino, Luca, Marino, Fabio, Asti, Emanuele Luigi Giuseppe, Bonavina, Luigi, Rausa, Emanuele, Asta, Martina, Belli, Andrea, Bianco, Francesco, Cervone, Carmela, Delrio, Paolo, Falato, Armando, Fares Bucci, Andrea, Guarino, Rita, Pace, Ugo, Rega, Daniela, De Luca, Emilia, Gallo, Gaetano, Sammarco, Giuseppe, Sena, Giuseppe, Vescio, Giuseppina, Santandrea, Letizia, Ugolini, Giampaolo, Zattoni, Davide, Chetta, Nicola, Logrieco, Gaetano, Vanella, Serafino, Garulli, Gianluca, Zanini, Nicola, Bondurri, Andrea, Cammarata, Francesco, Colombo, Francesco, Foschi, Diego, Lamperti, Giulia Maria Beatrice, Maffioli, Anna, Sampietro, Gianluca Matteo, Yakushkina, Al'ona, Zaffaroni, Gloria, Cicuttin, Enrico, Sibilla, Maria Grazia, Impellizzeri, Harmony, Inama, Marco, Moretto, Gianluigi, Mochet, Sylvie, Ponte, Elisa, Usai, Antonella, Mancini, Stefano, Sagnotta, Andrea, Solinas, Luigi, Bolzonaro, Elisa, Tamini, Nicolò, Curletti, Gianluca, Galleano, Raffaele, Malerba, Michele, Campanella, Sofia, Cocorullo, Gianfranco, Colli, Francesco, De Marco, Paolino, Falco, Nicolò, Fontana, Tommaso, Kamdem Mambou, Leonel jospin, La Brocca, Antonella, Licari, Leo, Randisi, Brenda, Rizzo, Giovanna, Rotolo, Giulia, Salamone, Giuseppe, Tutino, Roberta, Venturelli, Paolina, Malabarba, Stefano, Sgrò, Alessandro, Vella, Ivan, Cirillo, Bruno, Crocetti, Daniele, De Toma, Giorgio, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Belvedere, Angela, Bianchini, Stefania, Binetti, Margherita, Birindelli, Arianna, Tonini, Valeria, Podda, Mauro, Pulighe, Fabio, De Rosa, Michele, Bono, Lorenzo, Borghi, Felice, Geretto, Paolo, Giuffrida, Maria Carmela, Lauro, Corrado, Marano, Alessandra, Pellegrino, Luca, Salusso, Paola, Sasia, Diego, Campanelli, Michela, Realis Luc, Alberto, Trompetto, Mario, Cardia, Roberto, Cillara, Nicola, Giordano, Antonio Nicola, Costanzo, Antonio, Giovilli, Mario Alessandro, Turati, Luca, Canonico, Silvestro, Sciaudone, Guido, Selvaggi, Francesco, Selvaggi, Lucio, Albsoul, Nader, AlBsoul, Ahmad, Alkhatib, Ala'a Aldeen, Alsallaq, Osama, Amarin, Justin Z., Ayoub, Rami, Bsisu, Isam, El Muhtaseb, M S, Jabaiti, Mohammad, Melhem, Jamal, Qwaider, Yasmeen Z., Salameh, Mohammad Hasan, Suleihat, Ahmad, Suradi, Haya H., Alammarin, Mohammad, Aljaafreh, Almoutuz, Bani hani, Mohammad, Bani hani, Zeina, Bani Hani, Farah, Fahmawee, Toqa, Hamouri, Shadi, Katanani, Cyrine, Tawalbeh, Ra'fat, Tawalbeh, Tamara, Zawahrah, Hassan, Abou Chaar, Mohamad K., Abusalem, Lana, Al-Masri, Mahmoud, Al-Najjar, Hani, Barghuthi, Lutfi, Ahmed, Zahra, Maulana, Adnan, Ngotho, Omar, Kamau, Charbel, Stanley Mwenda, Aruyaru, Bosire, Fridah, Mwachiro, Elizabeth, Parker, Robert, Simel, Ian, Sylvester, Kimutai, Althini, Abdulmunem Ahmed Mustafa, Elbarouni, Sofian, Elbeshina, Aya Elseed, Gwea, Ahmed, Malek, Ans, Masoud Farag, Wedad Albashir, Abdalei, Abdulwahab, Abdel Malik, Abu Baker, Abo-khammash, Areej, Abuhlaiga, Ma'aly, Adnan, Nour, Albaggar, Marwa, Alfitory, Asma, Aljanfi, Asma, Almuzghi, Fakhruddin, Altumei, Zohoor, Alzabti, Fatima, Ashoushan, Hana, Assalhi, Mohamed, Azzubia, Joma, Bnhameida, Sondos, Delhen, Malik, Elshafei, Houssein, Elteir, Hana, Esbaga, Fatima, Gobbi, Abdel Aziz, Hamouda, Fatma, Hilan, Hamdan, Ismail, Rania, Jebran, Fieruz, Kasbour, Muataz, Maderi, Galia, Mohammad, Saja, Mohammed, Burooj, Murtadi, Habib, Mustafa, Hamassat, Rajab, Mohamed, Trenba, Sarah, Wafaa, Mariam, Al Sagheir, Eman, Almigheerbi, Alabas, Alzahaf, Ahmed, Bahroun, Sumayyah Ghayth, Ben Dallah, Najah, Elshaibani, Mahmoud, Eswaye, Haitem, Karar, Maha, Omar, Samah, Younes, Eman, Younes, Maha, Zreeg, Dafer, Abujamra, Saleh, Ashour, Firas, Elgammudi, Mala, Omar F. Aljadidi, Wesal, Saddouh, Enas, Sharif, Randa, Alabuzidi, Aya, Alwerfally, AbdulMawlay, Aribi, Sarra, Bibas, Fatma, Elfaituri, Taha, Elhajjaji, Yasmine, Khaled, Ala, Khalil, Wegdan, Layas, Tesneem, Soula, Enas, Tarek, Ahmed, Abu hallalah, Muad fathi khalleefah, Ahmed, Hazem Abdelkarem, Alsharef, Tagwa, Ben Saoud, Abdulsalam Ali, El Gharmoul, Tasnim, Elhadi, Ahmed, Elrais, Safa, Shebani, Abdulhalim, Zarti, Heba, Zeiton, Asaid, Ambrazevicius, Marijus, Kaselis, Nerijus, Stakyte, Migle, Aliosin, Oleg, Cizauskaite, Agne, Dailidenas, Sarunas, Eismontas, Vitalijus, Kybransiene, Migle, Nutautiene, Vitalija, Samalavicius, Narimantas, Simcikas, Dainius, Slepavicius, Algirdas, Tamosiunas, Albinas, Ubartas, Nerijus, Zeromskas, Paulius, Bradulskis, Saulius, Dainius, Edvinas, Juočas, Juozas, Kubiliute, Egle, Kutkevičius, Juozas, Opolskis, Aurimas, Parseliunas, Audrius, Subocius, Andrejus, Virbickaite, Egle, Zuikyte, Diana, Bogusevicius, Algirdas, Buzaite, Kristina, Čepuliené, Daiva, Cesleviciene, Ieva, Cesna, Vaidotas, Gribauskaite, Jolanta, Ignatavicius, Povilas, Jokubauskas, Mantas, Liugailaitè, Monika, Margelis, Ernest, Mazelyte, Ruta, Pankratjevaitè, Lina, Pažusis, Matas, Rackeviciute, Agne, Saladyte, Justina, Škimelytè, Monika, Šlenfuktas, Vygintas, Sudeikyte, Monika, Tamelis, Algimantas, Vanagas, Tomas, Žumbakys, Žygimantas, Atkociunas, Aivaras, Dulskas, Audrius, Kuliavas, Justas, Birutis, Justas, Paškevičius, Sigitas, Šatkauskas, Mindaugas, Danys, Donatas, Jakubauskas, Matas, Jakubauskiene, Lina, Kryzauskas, Marius, Lipnickas, Vytautas, Makūnaitè, Gabija, Rasoaherinomenjanahary, Fanjandrainy, Rasolofonarivo, Herizo, Samison, Luc Hervé, Banda, Bitiel, Msosa, Vanessa, Ahmad Izzuddin, Ahmad Imran, Das, Andre, Gan, Ying Yee, Shong Sheng, Tan, Siaw, Jia yng, Ab Rahim, Mohd Fadliyazid, Abang Jamari, Dyg Zahratul Hamrak, Che Husin, Nurfariza, Kamarulzaman, Muhd Yusairi, Lim, Yi Ping, Mohamed Kamil, Nil Amri, Mohd Hassan, Mohd Razeen, Mohd Sahid, Saidah, Mustafa, Johari, Ng, Elaine Hui Been, Wan Khazim, Wan Khamizar, Chang Ern, Ng, Lingeshan, P.g., Sulaiman, Syariz Ezuan, Ang, Sue Ean, Bin Mohamad Sithik, Muhammad Navid, Cheong, Yih Jeng, Deva Tata, Mahadevan, Jia Xian, Law, Kadravello, Aravinthan, Koh, I-Ern, Ng, Li-Yen, Ng We Yong, Yuki Julius, Palayan, Kandasami, Sam, Chi Xuan, Siow Jin, Phuah, Tan Ern Hwei, Jeremy, Tang, Yita, Ter, Alvin Zubin, Wong, Michael Pak-Kai, Zakaria, Andee Dzulkarnaen, Zakaria, Zaidi, Henry, Fitjerald, Kalaiselvan, Thyivya, Abd Karim, Muhammad Fairuz Shah, Abdul Aziz, Mohamed Rezal, Abdul Aziz, Nora, Khong, Tak Loon, Lau, Peng Choong, Lim, Hiong Chin, Roslani, April Camilla, Seak, Jonathan Chen Ken, Wong, Sui-Weng, Wong, Lai Fen, Yeen Chin, Leow, Anyanwu, Mercy Chinemerem, Busuttil, Zachary, Calleja, Thomas, Chircop, Kurt Lee, Cutajar, Ruth, Dimech, Andrew Michael, Galea, Joseph, Gascon Perai, Kiara, Gatt, Ruth, Kelman, Lisa, Micallef, Elizabeth, Nwolu, Favour, Sammut, Kim, Thompson, Joanna, Warwicker, Sean, Zammit, Matthew, Cordera, Fernando, Cruz González, Efraín, Sánchez-García, Jorge, Barbosa Camacho, Francisco José, Barrera López, Francisco Javier, Zuloaga Fernandez del Valle, Carlos Jose, Acosta, Eric, González Espinoza, Iván Romarico, Moreno, Perla, Cortes-Flores, Ana Olivia, Fuentes Orozco, Clotilde, Gonzalez Ojeda, Alejandro, Corro Díaz González, Samantha, Martinez, Laura, Mosqueda Amador, Bonifacio, Novoa, Armando, Olazo Espejo, Dennet Arturo, Jimenez, Alejandro, Lopez Rosales, Federico, Vanoye, Elva Gabriela, Garcia Gonzalez, Luis Alberto, Miranda-Ackerman, Roberto Carlos, Solano-Genesta, Manuel, Alvarez-Cano, Alethia, Romero-Garza, Hector Hugo, Medina-Franco, Heriberto, Mejía-Fernández, Lorelí, Salgado-Nesme, Noel, Vergara-Fernandez, Omar, Gutiérrez-Mota, Guadalupe Montserrat, Hernandez Vera, Francisco Xavier, Llantada Lopez, Anabella, Morgan Villela, Gilberto, Ramirez Padilla, Felipe de Jesus, Tapia Marin, Walezka, Martínez Maldonado, Mónica, Sánchez Suárez, Ramses, Troche, José Manuel, Benyaiche, Chaymae, Outani, Oumaima, Amine, Souadka, Benkabbou, Amine, Majbar, Anass Mohammed, Mohsine, Raouf, Rafik, Ali, Oung, Thida, Tin, Moe Moe, Plarre, Philipp, Alberga, Anna, Sluiter, Nina, Tuynman, Jurriaan, Blok, Robin, Cömert, Didem, Hompes, Roel, Kalff, Marianne, Stellingwerf, Merel Elisabeth, Tanis, Pieter, van Berge Henegouwen, Mark, van Praag, Elise Maria, Wisselink, Daan, Gerhards, Michael, Lopes Cardozo, Josephine, Westerduin, Emma, de Jonge, Joske, van Geloven, Aaw, van Schilt, Kaz, den Boer, Frank, Stoots, Simone, Vlek, Stijn, Adams, Jamie, Al-Busaidi, Ibrahim S., Budd, Gabrielle, Choi, Seung il, Chu, Michael Jen Jie, Ganugapati, Anurag, McKinstry, Lucy, Pascoe, Rebecca, Richards, Simon, Rosser, Kenrick, Stevenson, Annie, White, Rebecca, Farik, Shebani, Kwun, Jin, Murad, Ahmed, Cowan, Sarah, Hall, Timothy, Hayton, Michael, Malam Sani, Laminou, Oumarou Garba, Souleymane, Amadou Magagi, Ibrahim, Habou, Oumarou, Aliyu, Halima, Daniyan, Muhammad, Sholadoye, Tunde T., Abdullahi, Lawal, Anyanwu, Lofty-John, Mohammad Mohammad, Aminu, Muhammad, Abubakar Bala, Sheshe, Abdurrahman Abba, Suleiman, Ibrahim, Adesina, Alaba, Awolowo, Ajibola, Onuoha, Clement, Salami, Omotayo, Taiwo, Ogechukwu, Taiwo, Agboola, Kache, Stephen, Makama, Jerry Godfrey, Sale, Danjuma, Abiola, Olajide, Ajao, Akinlabi, Ajiboye, Anthony, Etonyeaku, Amarachukwu, Olaogun, Julius, Adebanjo, Ademola, Adesanya, Opeoluwa, Afolayan, Michael Olatunji, Balogun, Olanrewaju, Makanjuola, Ayomide, Nwokocha, Samuel, Ojewola, Rufus Wale, Olajide, Thomas Olagboyega, Aderounmu, Adewale, Adesunkanmi, Abdul-Rashid, Agbakwuru, Augustine, Akeem Aderogba, Adeleke, Alatise, Olusegun Isaac, Arowolo, Olukayode, Lawal, Oladejo, Mohammed, Tajudeen, Ndegbu, Chinedu, Olasehinde, Olalekan, Wuraola, Funmilola, Akinkuolie, Akinbolaji, Mosanya, Arinzechukwu, Ayandipo, Omobolaji, Elemile, Peter, Lawal, Taiwo Akeem, Ali SANI, Samuel, Garba, Stephen, Hauwa SANI, Rebecca, Olori, Samson, Onyebuashi, Henry, Umoke, Ifeanyi, Adenuga, Adedire, Adeyeye, Ademola, Habeeb, Olufemi, Lawal, Bashir, Nasir, Abdulrasheed, Aahlin, Eirik Kjus, Kjønås, Didrik, Myrseth, Elisabeth, Abbasy, Jibran, Alvi, Abdul, Saleem, Omair, Afzal, Asma, Nazir, Anam, Farooq, Muhammad, Liaqat, Ayesha, Naqi, Syed Asghar, Raza, Ali, Sarfraz, Muzna, Sarwar, Muhammad, Banglani, Muntaha, Munir, Ambreen, Sehrish, Rahmat, Ayub, Bushra, Sayyed, Raza, Altaf, Amna, Ayub, Saima, Saeed, Komal, Syed, Bilal, Akbar, Sana Amir, Anwer, Abdul Wahid, Khan, Ruqayya Naheed, Khan, Amina Iqbal, Khattak, Shahid, Mohtasham, Sameen, Parvaiz, Muhammad Asad, Syed, Aamir Ali, Ansari, Abdul Basit, Shahzad, Noman, Khaliq, Tanwir, Rashid, Isbah, Waqar, Shahzad Hussain, Abu Al-saleem, Hasan, Abu Alqumboz, Amjad, Alqadi, Mohammad, Amro, Adham, Assa, Rawan, Awesat, Eman, Ayyad, Rawan, Hammad, Mohammed, Haymony, Ayat, Hijazi, Bassel, Hmeidat, Bara, Lahaseh, Rowaa, Qawasmi, Aseel, Rajabi, Alaa, Shehada, Mohammed, Shkokani, Sundus, Yaghi, Yasmine, Yaghi, Nadine, AlZohour, Mohammad, Farid, Mohammad, Habes, Yousef Mahmoud, Juba, Wesam, Nubani, Yanal, Rabee, Abdelrahman, Sa'deh, Mohammad, Abed, Saeed, Al basos, Iyad, Alswerki, Mohammad, Ashour, Dina, Awad, Israa, Diab, Samar, El Jamassi, Alaa, El-Kahlout, Sahar, Elhout, Somaya, Hajjaj, Ahmed N K, Hasanain, Doaa, Nabil hajjaj, Baraa, Obaid, Mohammed, Saikaly, Eman, Salhi, Ahmed, Al-Tammam, Hiba, Almasri, Murad, Baniowda, Muath, Beshtawi, Doha, Horoub, Ali, Misk, Rami, Mohammad, Bayan, Qasrawi, Rami, Sholi, Tasnim, Abu-Nimeh, Samar, Abu-srour, Abrar, Abukhalaf, Sadi A., Adawi, Samer, Alsalameh, Barah, Ayesh, Kholoud, Elqadi, Muawiyah, Hammouri, Ahmad, Karim Mustafa, Fatima, Marzouqa, Natalie, Melhem, Shatha, Miqdad, Dima, Mohamad, Balqees, Rawhi, Mhammed, Abu Ahammala, Ayman B., Abu Ataya, Ahmed, Abu Jayyab, Israa, Al-Shwaikh, Samar, Alagha, Othman, Alasttal, Mohammed, Awadallah, Haneen, Elblbessy, Mahmood, Fares, Jehad, Jarbou, Akram, Mahfouz, Ibtisam, Albahnasawi, Moath A., Abo mahadi, Asmaa', Abuelhatal, Hasan, Abuelqomboz, Ayham, Almoqayyad, Abdelrahman, Alwali, Abdallah, Balaawi, Reem, Hamouda, Mahmoud, Humeid, Mohammed, Jedyan, Abdullah, Mahmoud Abu hamam, Tasneem, Matar, Ghadeer, Salem, Ali, Samra, Tahani, Shaheen, Nureddin, Shihada, Karam, A.Nemer, Ayoob, Abu Al Amrain, Mahmoud, Abu Alamrain, Abdulwhhab, Abu Jamie, Najlaa, Abu-Rous, Mohammed R., Alfarra, Nada, AlTaweel, Mohammed, Alwhaidi, Noor, Hamed, Ramadan, Saqqa, Bader, Shaheen, Ahmad, Aljaber, Dana, Aljaberi, Loay, Alwaheidi, Malak, Jawaada, Assef, Khaldi, Hani, Qahoush, Rami, Qari, Jalil, Saadeh, Rana, Salim, Ahlam, Yacoub, Aseel, Abbas, Abbas, Abu shua'ib, Rana, Abu Zainah, Baraa, AbuSirrees, Mahmoud, Babaa, Basheer, Barhoush, Ola, Belal qadomi, Asef, Daraghmeh, Laith, Haji, Reema, Khatatbeh, Alaa, Khatib, Lana, Qarariah, Salsabeel, Quzmar, Yara, Safadi, Khalil, Salameh, Roqaya, Hassan, Mohammad, Herzallah, Shifaa, Massad, Loai, Nazzal, Ahmed, Nazzal, Ranin, Escobar, Dennis, Machain V, Gustavo Miguel, Rodriguez Gonzalez, Agustin, Chachaima Mar, Jorge Emerson, Chinchihualpa Paredes, Nathaly Olga, Cuba, Vicente, Lopez, Walter, Niquen Jimenez, Maria Milagros, Sanchez Bartra, Nestor Alberto, Sapallanay Ojeda, Olenka, Sequeiros, Diego, Toscano Pacheco, Andrea, Vergara, María, Abarca, Sol, Alcorta, Rodrigo, Borda-Luque, Giuliano, Eusebio Zegarra, Ivan Edward, Luján López, Claudia, Marrufo, Mirella, Mogrovejo, Cinthya, Nomura, Andrea, Rodríguez Angeles, Yamile, Vidal Meza, Maitza Rosario, Zavala, Gabriela, Castillo Arrascue, José Neiser, Hidrogo Cabrera, Jomara Caroline, Larrea vera, José Julio Mariano, Osorio, Miguel, Ylatoma Díaz, Edgar Alcides, Fontanilla, Mark Anthony, Fuentes, Joseph Roy, Salazar, Anna Leah, Dominguez, Genieve, Lopez, Marc Paul, Macalindong, Shiela, Onglao, Mark Augustine, Ramirez, Arjel, Sacdalan, Marie Dione, Tampo, Mayou Martin, Uy, Gemma Leonora, Mangahas, Jeremiah, Yabut, Kenneth, Cañete, Joannes Paul, Cansana, Bernalynn Eris, Castro, Ernes John, Lipana, Maria Kaiserin, Roxas, Manuel Francisco, Zara, Vlu Jean, Chroł, Maciej, Franczak, Paula, Orłowski, Michał, Budzyński, Piotr, Budzyński, Andrzej, Bury, Pawel, Czerwińska, Agata, Dworak, Jadwiga, Dziedzic, Jacek, Kisielewski, Michał, Kulawik, Jan, Lasek, Anna, Małczak, Piotr, Migaczewski, Marcin, Pędziwiatr, Michał, Pisarska, Magdalena, Radkowiak, Dorota, Rubinkiewicz, Mateusz, Rzepa, Anna, Skoczylas, Tomasz, Stanek, Maciej, Truszkiewicz, Katarzyna, Wierdak, Mateusz, Winiarski, Marek, Zarzycki, Piotr, Zub-Pokrowiecka, Anna, Kowalewski, Piotr, Roszkowski, Rafał, Walędziak, Maciej, Tomé, Miguel, Patrocinio, Sara, Guerreiro, Ines, Almeida, Filipe, de Sousa, Xavier, Monteiro, Nuno, Costa Santos, Maria Teresa, de Oliveira, Daniela, Lopes Serra, Marta, Morgado, Daniela, Neves, Christian, Oliveira, Ana Carolina, Pimentel, Alice, Silva, Sofia, Carvalho, Márcia, Carvalho, Lúcia, Magalhães, Joana, Matos, Leonor, Monteiro, Tânia, Ramos, Carlota, Santos, Vanessa, Barbosa, José, Costa-Maia, Jose, Devezas, Vítor, Fareleira, Ana, Fernandes, Cristina, Gonçalves, Diana, Mora, Henrique, Morais, Marina, Silva de Sousa, Fabiana, Catarino Santos, Sara, Logrado, Ana, Tojal, André, Amorim, Edgar, Cunha, Miguel F., Fazenda, Ana, Melo Neves, João Pedro, Sampaio da Nóvoa Gomes Miguel, Inês Isabel, Veiga, Diogo, Azevedo, José, Cardoso Louro, Hugo, Leite, Mariana, Bairos Menezes, Maria, Gama, Bárbara, Brito, Diana, Cruz Martins, Marta Cristina, Graça e Magalhães, André, Longras, Ana Catarina, Lourenço, Rita, Matos, Diana, Castro, Luis, Policarpo, Filipa, Romano, Joana, Monteiro, Cristina, Pinto, Diogo, Duarte, Marina, Fortuna Martins, Sónia, Oliveira, Mariline, Galvão, Diogo, Martins, Lisandra, Silva, Anaisa, Taranu, Viorel, Vieira, Bárbara, Neves, Jessica, Oliveira, Simone, Ribeiro, Hugo, Cinza, Margarida, Felix, Rosa, Machado, Arnaldo, Oliveira, Joana, Patrício, Joana, Pedroso de Lima, Rita, Pereira, Mário, Rocha Melo, Miguel, Velez, Cristina, Abreu da Silva, Alberto, Claro, Mariana, Costa Santos, Daniel, Ferreira, Andreia, Capote, Hugo, Rosado, Daniela, Taré, Filipa, Nogueira, Oriana, Ângelo, Miguel, Baiao, José Miguel, Guimarães, Andreia, Marques, João, Nico Albano, Miguel, Silva, Marta, Valente da Costa, Ana, Vieira Caroço, Teresa, Almeida Braga, Sara, Capunge, Ines, Fragoso, Marta, Guimarães, João, Pinto, Bruno, Ribeiro, João, Angel, Miguel, Fialho, Guilherme, Guerrero, Monica, Campos Costa, Filipa, Cardoso, Diogo, Cardoso, Vasco, Alves, Magda, Estalagem, Inês, Louro, Tiago, Marques, Cláudia, Martelo, Rita, Morgado, Miguel, Canotilho, Rita, Correia, Ana Margarida, Martins, Pedro, Peyroteo, Mariana, Gomes, João, Monteiro, Rita, Romano, Manuela, Alves, Daniela Macedo, Peixoto, Rita, Quintela, Catarina, Jervis, Maria João, Melo, Débora, Pacheco, André, Paixão, Valter, Pedro, Vera, Pimenta, Joana, Pimenta de Castro, João, Rocha, Ana, Beuran, Mircea, Ciubotaru, Cezar, Diaconescu, Bogdan, Hostiuc, Sorin, Negoi, Ionut, Stoica, Bogdan, Anokhin, Evgeny, Kuznetsov, Georgy, Oganezov, Giorgi, Paramzin, Fedor, Romanova, Ekaterina, Rutkovskii, Valeryan, Rutkovskii, Vasilii, Shushval, Mikhail, Zabiyaka, Mikhail, Dzhumabaev, Khasan, Ivanov, Valerii, Mamedli, Zaman, Achkasov, Sergey, Balkarov, Artem, Nabiev, Elnur, Nagudov, Marat, Rybakov, Evgeny, Saifutdinova, Karina, Sushkov, Oleg, Joseph, Lule, Ndayishimiye, Isaac, Faustin, Ntirenganya, Mutabazi, Alphonse Zeta, Mvukiyehe, Jean Paul, Nsengimana, Vizir J.P, Uwakunda, Carine, Abbas, Mohammad Monir, Akeel, Nouf, Aljiffry, Murad, Awaji, Kholoud, Farsi, Ali, Jamjoum, Ghader, Khoja, Ahmad, Maghrabi, Ashraf, Malibary, Nadim, Nassif, Mohammed, Saleem, Abdulaziz, Sultan, Abdullah, Tashkandi, Wail, Tashkandi, Hanaa, Trabulsi, Nora, Ba, Mouhamadou Bachir, Diallo, Adja Coumba, Ndong, Abdourahmane, Cuk, Vladica, Janković, Uroš, Koh, Sharon Zhiling, Koh, Frederick, Lee, Kuok Chung, Lee, Kai Yin, Lee, Sean, Leong, Wei Qi, Lui, Su Ann, Prakash, Prajwala, Grosek, Jan, Norcic, Gregor, Tomazic, Ales, Fitchat, Nicolas, Jaich, Robert, Wineberg, Devorah, Koto, Modise Zacharia, Baiocchi, Daniella, Clarke, Damian, Steenkamp, Christina Johanna, Bannister, Sharon, Boutall, Adam, Chinnery, Galya, Coccia, Anna, Dell, Angela, Karjiker, Parveen, Kloppers, Christo, Loxton, Nicholas, Mabogoane, Tumi, Malherbe, Francois, Panieri, Eugenio, Rayamajhi, Shreya, van Wyngaard, Tirsa, Warden, Claire, Madiba, T E, Pillay, Nivashen, Brooks, Savannah, Kruger, Charlise, Van Der Merwe, Lisa Hannah, Gool, Ferhana, Kariem, Maahir, Bougard, Heather, Kariem, Nazmie, Noor, Fazlin, Pillay, Reantha, Steynfaardt, Leandi, González González, Lucía, Marín Santos, José Miguel, Martín-Borregón, Paula, Martínez Caballero, Javier, Nevado García, Cristina, Rodriguez Fraga, Pastora, De Castro Parga, Gonzalo, Fernández Veiga, Maria Pilar, Garrido López, Lucía, Infante Pino, Hugo, Lages Cal, Irene, López Otero, Marta, Nogueira Sixto, Manuel, Paniagua García Señorans, Marta, Rodríguez Fernández, Laura, Ruano Poblador, Alejandro, Rufo Crespo, Erika, Sanchez-Santos, Raquel, Vigorita, Vincenzo, Alonso Batanero, Ester, Asnel, Dorisme, Cifrian Canales, Isabel, Contreras Saiz, Elisa, De Santiago Alvarez, Irene, Díaz Vico, Tamara, Fernandez Arias, Sebastian, Fernández Martínez, Daniel, García Bernardo, Carmen, García Flórez, Luis Joaquín, Garcia Gutierrez, Carmen, García Munar, Manuel, Márquez Zorrilla Molina, Carlos Alberto, Merayo, Marta, Michi Campos, José Luis, Moreno Gijon, Maria, Otero-Diez, Jorge L., Rodicio Miravalles, Jose Luis, Solar-Garcia, Lorena, Suárez Sánchez, Aida, Truan, Nuria, Alejandre Villalobos, Cristina, Caballero Díaz, Yurena, Jimenez, Marta, Montesdeoca, Dacil, Navarro-Sánchez, Antonio, Vega, Victor, Beltrán de Heredia, Juan, Gómez, Zahira, Jezieniecki, Carlos, Legido Morán, Ana Patricia, Montes-Manrique, Mario, Rodriguez-Lopez, Mario, Ruiz Soriano, María, Trujillo Díaz, Jeancarlos, Vazquez Fernandez, Andrea, Argudo, Nuria, Pera, Miguel, Torrent Jansà, Laia, García Domínguez, Melody, Goded, Ignacio, Roldón Golet, Marta, Talal El-Abur, Issa, Utrilla Fornals, Alejandra, Zambrana Campos, Vanesa, Aguilar Martinez, Maria Del Mar, Bosch, Marina, García-Catalá, Luis, Sánchez-Guillén, Luis, Artigau, Eva, Gomez Romeu, Nuria, Julià Bergkvist, David, Espina Perez, Beatriz, Morató, Olga, Olona, Carles, Diéguez, Beatriz, Forero-Torres, Alexander, Losada, Manuel, Gomez-Abril, Segundo, Gonzálvez, Paula, Martinez, Rosario, Navarro Martínez, Sergio, Payá-Llorente, Carmen, Pérez Rubio, Álvaro, Santarrufina Martinez, Sandra, Sebastián Tomás, Juan Carlos, Trullenque Juan, Ramon, Gegúndez Simón, Alberto, Maté, Paloma, Prieto-Nieto, Maria Isabel, Rubio-Perez, Ines, Urbieta, Aitor, Vicario Bravo, Marina, Abelló, David, Frasson, Matteo, Garcia-Granero, Alvaro, Abad Gurumeta, Alfredo, Abad-Motos, Ane, Lucena-de Pablo, Elena, Nozal, Beatriz, Ripollés-Melchor, Javier, Salvachúa, Rut, Ferrero, Esther, Garcia-Sancho Tellez, Luis, Picardo, Antonio L., Rojo López, Jose Alberto, Zorrilla Matilla, Laura Patricia, Cagigas Fernandez, Carmen, Castanedo Bezanilla, Sonia, Estevez Tesouro, José, Fernandez-Diaz, Maria Jose, García Cardo, Juan, Gomez Ruiz, Marcos, Gonzalez-Tolaretxipi, Erik, Jimeno Fraile, Jaime, Poch, Cristobal, Rodriguez-Aguirre, Montserrat, Troche Pesqueira, Noemí, Trugeda-Carrera, Maria Soledad, de la Torre, Javier, Blanco-Colino, Ruth, Espin-Basany, Eloy, Espinosa-Bravo, Martin, Morales Comas, Clara, Reyes Afonso, Eduardo, Rivero Déniz, Joaquín, Siso Raber, Christian, Verdaguer Tremolosa, Mireia, Chandrasinghe, Pramodh, Kumarage, Sumudu, Wijekoon Arachchilage, Nimeshi, Abdalla Ahmed Elkamel, Ahmed, A. Adam, Mohammed, Blomme, Nina, Thorell, Anders, Wogensen, Fredrik, Älgå, Andreas, Ansarei, Dhirar, Celebioglu, Fuat, Heinius, Göran, Nigard, Linda, Pieniowski, Emil, Ahlqvist, Sandra, Björklund, Ida, Frånberg, Andreas, Håkansson, Martina, Adamo, Karin, Franklin, Oskar, Sund, Malin, Wiberg, Rebecca, Andersson, Yvette, Chabok, Abbas, Nikberg, Maziar, Kugelberg, Alexander, Canonica, Claudia, Christoforidis, Dimitrios, Fasolini, Fabrizio, Gaffuri, Paolo, Giuliani, Mauro, Meani, Francesco, Popeskou, Sotirios Georgios, Pozza, Silvia, Wandschneider, Wiebke, Peterer, Lorenz, Widmer, Lukas Werner, Zimmermann, Bernd, Bakoleas, Panagiotis, Chanousi, Iris, Charalampidou, Lydia, Grochola, Lukasz Filip, Heid, Franziska, Ntaoulas, Sotirios, Outos, Michail, Peros, Georgios, Podolska-Skoczek, Hanna, Reinisch, Katharina Beate, Zielasek, Christian, Demartines, Nicolas, Gilgien, Jérôme, Kefleyesus, Amaniel, St-Amour, Pénélope, Toussaint, Arnaud, Alhimyar, Maryam, Alsaid, Bayan, Alyafi, Amr, Alkhaledi, Ahmad, Kouz, Basel, Omarain, Ahmad, Al-Sabbagh, Yusra, Alkhatib, Haya, Sara, Samer, Alhaj, Ahmad, Danial, Aghyad, Kadoura, Lama, Maa Albared, Sarah, Monawar, Yamen, Nahas, Louei, Abd, Barook, Saad, Ahmad, Wakkaf, Habib, Bouzaiene, Hatem, Ghalleb, Montassar, Akaydin, Elif, Akbaba, Ata Cem, Atakul, Onur, Baltaci, Ege, Besli, Sevval, Burgu, Gökçen, Cenal, Ulukan, de Muijnck, Cansu, Demirkaya, Hasan Can, Dogruoz, Alper, Gezer, Zeynep Ipek, Gündoğdu, Yasemin, Kara, Merve, Korkmaz, Hasan Kürşad, Kurtoğlu, Gökalp Kağan, Ozben, Volkan, Ozmen, Berk Baris, Pektaş, Ahmet Murat, Sel, Eda Kübra, Yenidünya, Nilüfer, Bengur, Fuat Baris, Oral, Berke Mustafa, Yozgatli, Tahir Koray, Abdullayev, Seymur, Gunes, Mehmet Emin, Sahbaz, Nuri Alper, Banaz, Tuba, Kargici, Kübra, Kuyumcu, Omer Faruk, Yanikoğlu, Erkan, Yeşilsancak, Merve, Yilmaz, Duygu, Aktas, Melik Kagan, Rencuzogullari, Ahmet, Isik, Arda, Leventoğlu, Sezai, Yalçinkaya, Ali, Yüksel, Osman, Kalayci, Mustafa U, Kara, Yasin, Sarici, Inanc Samil, Akin, Alp, Alemdağ, Gökçe nur, Arslan, Ekin, Baki, Bahadir Emre, Bodur, Muhammed Selim, Calik, Adnan, Candas Altinbas, Bahar, Cihanyurdu, Irem, Erkul, Oğuz, Gül, Burak, Guner, Ali, Köse, Beyza, Semiz, Anil, Sevim, Şule, Tayar, Serkan, Tomas, Kadir, Tüfek, Ozan yavuz, Türkyilmaz, Serdar, Uluşahin, Mehmet, Usta, Arif, Yildirim, Reyyan, Güler, Sertaç Ata, Tatar, Ozan Can, Varol, Ecenur, Kirimtay, Busenur, Uysal, Muhammed, Yildiz, Alp, Kose, Emin, Ciftci, Ahmet Burak, Çolak, Elif, Eraslan, Huseyin, Kucuk, Gultekin Ozan, Yemez, Kürşat, Lule, Herman, Bienfait, Mumbere, Bua, Emmanuel, Okalany, Noella, Basarab, Maksym, Bielosludtsev, Oleksii, Kolhanova, Kateryna, Perepelytsia, Kateryna, Romanukha, Kateryna, Savenkov, Dmytro, Siryi, Stanislav, Tereshchenko, Maksym, Viacheslav, Nezamai, Volovetskyi, Anton, Kebkalo, Andrey, Tryliskyy, Yegor, Tyselskiy, Volodimir, Bruce, Eilidh, Chow, Bing Lun, Iddles, Emma, McGuckin, Sarah, Newall, Nicola, Ramsay, George, Sharma, Parivrudh, Stewart, Caitlin, Wong, Jeremy, Badran, Abdul, Bath, Michael, Belais, Fanny, Butt, Eman, Joshi, Kaustuv, Kapur, Milan, Shaw, Mike, Townson, Adam, Williams, Christopher Yee Khang, Gray, Timothy, Greig, Robert, Husain, Mansoor, Murray, Elspeth, Mustafa, Ahmed, Asif, Ashar, Gokul, Arya, Shah, Max, Akitikori, Mabel Temisanren, Charalabopoulos, Alexandros, Davidson, Sophie, McNally, Sinead, Rupani, Shamil, Juma, Fatema, Mills, Sarah Catherine, Muirhead, Laura, Sellars, Kate, Walsh, Una, Warren, Oliver, Chambers, Alice, Hunt, Richard, Boyce, Stephen, Cornwall, Hannah, Tol, Isabel, Argyriou, Eleftherios Orestis, Eardley, Nicola, Povey, Meical, Aithie, Joanna M S, Irfan, Ahmer, McGuigan, Mari-Claire, Starr, Robert, Warren, Craig Russell, Archibald, Jess, Kirby, Georgia, Kisyov, Ivan, Khoo, Chun Kheng, Lee, Rachel, Photiou, Dana, Davis, Rowan, Prasad, Uday, Yang, P Zichu, Bird, Jonathan, Leung, Edmund, Summerour, Virginia, Currow, Chelise, Kiam, Jianshen, Tan, Gerald Jack Soon, Muthusami, Anitha, Pegba-Otemolu, Ibifunke, Urbonas, Tomas, Nunoo-Mensah, Joseph, Smolskas, Edgaras, Boddy, Alex, Gravante, Gianpiero, Hunter, David, Andrew, David, Koh, Amanda, Thompson, Amari, Adams, Lawrence, Clements, Hollie A, De Silva, Kasun, Ekpete, Ogbonnia, Haque, Seraj, Henderson, Scott, Ibrahim, Bilal, Jayasinghe, Thummini, Livie, Jennifer, Mailley, Keir, Nair, Gopikrishnan, Tan, Daniel, Baggaley, Caitlin, Dawidziuk, Aleksander, Szyszka, Bartosz, Barter, Charlotte, Gandhi, Nirav, Hassell, Karen, Hitchin, Samantha, Kelsall, Jennett, Nagy, Eva, Nessa, Ashrafun, Whisker, Lisa, Yanni, Fady, Ali, Mahmoud, Arora, Deeksha, Hediwattege, Sunanda, Kumarasinghe, Navam, Rathore, Munir, Tennakoon, Athula, Ali Ahmad, Syed Mustafa, Bajomo, Oreoluwa, Nadira, Fahema, Celentano, Valerio, Griffiths, Ewen, Karri, Rama Santhosh, Mak, Jason Kei Chak, Pipe, Michelle, Bhatti, Muhammad Iqbal, Rabie, Mohamed, Boyle, Connor, Hamilton, David, Mihuna, Aishath, Ng, James Chean Khun, Nicholson, Gary, Oliwa, Agata, Pearson, Robert, Rose, Anna, Yong, Shun Qi, Boereboom, Catherine, Hanna, Michael, Walter, Catherine, Greensmith, Thomas Samuel, Mitchell, Rachel, Monaghan, Eimear, Crawford, James, Moug, Susan, Blackwell, James, Boyd-Carson, Hannah, Herrod, Philip, Al-Allaf, Omar, Beattie, Miriam, Bullock, Cameron, Burman, Shivang, Clark, Gemma, Flamey, Nicolas, Flannery, Oliver, Harding, Alexander, Kodiatt, Ben, Lawday, Samuel, Mahapatra, Shivani, Mukundu Nagesh, Navin, Ng, Michael, Rye, Dupinderjit, Yoong, Andrel, Clark, Laura, Deans, Chris, Edirisooriya, Monisha, Carrington, Emma Victoria, Wong, Tsz Lun Ernest, Yusuf, Baasil, Chamberlain, Carla, Duke, Kathryn, Kmiotek, Elizabeth, Botes, Azel, Condie, Natalie, Schrire, Timothy, Shah, Reena, Thomas-Jones, Iolo, Yates, Charlotte, Anthony, Natasha, Matthews, Edward, Sahnan, Kapil, Tankel, James, Tucker, Sally, Winter Beatty, Jasmine, Ziprin, Paul, Duggan, William, Kantartzi, Anastasia, Sridhar, Shruthi, Khaw, Rachel Alys, Srivastava, Prakhar, Underwood, Charlotte, Alves do Canto Brum, Homero, Chopra, Sharat, Davis, Laura, Hughes, Rebecca, Tulley, Joshua, Alberts, Justin, Athisayaraj, Thomas, Olugbemi, Mojolaoluwa, Ahmad, Kasim, Chan, Claudia, Chapman, Gavin, Fleming, Hannah, Fox, Benjamin, Grewar, Julia, Hulse, Kate, Rutherford, Duncan, Sinead, Mackay, Smith, Scott, Speake, Doug, Vaughan-Shaw, Peter G, Christodoulides, Natasha, Kudhail, Simrit, Welch, Matthew, Husaini, Syed Muhibullah, Lambracos, Simon, Anyanwu, Chikamuche, Suresh, Rishi, Thomas, Jimmy Scott, Gleeson, Elizabeth, Platoff, Rebecca, Saif, Areeba, Enumah, Zachary, Etchill, Eric, Gabre-Kidan, Alodia, Bernstein, Mitchell, Carrano, Francesco Maria, Connors, Joseph, Lynn, Patricio, Melis, Marcovalerio, Newman, Elliot, Foster, Deshka S, Perrone, Kenneth, Titan, Ashley, Ahmad, Sarwat, Bafford, Andrea Chao M.D., Dal Molin, Marco, Hanna, Nader, Zafar, Syed Nabeel, Hemmila, Mark, Napolitano, Lena, Wong, Jane J, Chandler, Julia, Wood, Lauren, Wren, Sherry, Ottesen, Taylor, You, Lucia, Yu, Kristin, Arciénega Yañez, María del pilar, Ferreira Fernandes, Martin, González, Daniel, Cubas, Santiago, González, María Catalina, Zubiaurre, Vanessa, Demolin, Rodrigo, Giroff, Nicolas, Sciuto, Pablo, Campos, Maite, Rodríguez Cantera, Gabriela, Deepika, Garg, Simuchimba, Elliot, Bulaya, Anadi, Chibuye, Chali, Chirengendure, Bright, Kabale, Mary-Rose, Kabongo, Kizito, Munthali, James, Mweso, Oliver, Pikiti, Francis, Otieno, James, Lai, Log Tung, Blackman, Brighid, Richards, Sophie, Subramaniam, Suren, Karim, Rafid, Kok, Nathan, Lee, Yanni Dion, Ali, Shabina, Sinha, Aanjaneya, Corrigan, Robert, Barnes, Nicole, Wong, Florence, Dennis, Grace, Jedamzik, Julia, Phillips, Emil, Piette, Wivine, Van hentenryck, Marie, Koco, Houenoukpo, Lawani, Souliath, Kassa, Mamo Woldu, Santos Bezerra, Tainá, Gribnev, Petar, Dimitrov, Dobromir, Krastev, Panche, Oum, Sovannarith, Bonghaseh, Divine Tim, Al Farsi, Maryam, Alsharqawi, Nourah, Acevedo, Veronica, Castillo Barbosa, Andrea Carolina, Giron, Felipe, Leon Rodriguez, Jimmy Paul, Kučan, Darko, Rosko, Damir, Barsic, Neven, Župan, Domagoj, Hegazi, Amgad, Trunčíková, Vendula, Fryba, Vladimir, Mohamed, Mostafa, Sultan, Ahmed, Nagi, Ahmed, Rashad Temerik, Abdallah, Elshawy, Mohamed Elemam, Mahmoud, Moustafa Ibrahim, Omar, Shrouk, Anwar, Mohamed, Rageh, Tarek, Elmokadem, Aya, Gaballa, Khaled, Teppo, Sandra, Turunen, Antti, Pengermä, Pasi, Ballouhey, Quentin, Bergeat, Damien, Weyl, Ariane, Hain, Elisabeth, Gyedu, Adam, Yenli, Edwin, Osei-Poku, Dorcas, Rompou, Vaia-Aliki, Zoikas, Athanasios, Gaitanidis, Apostolos, Koukis, Georgios, Perivoliotis, Konstantinos, Tavlas, Panagiotis, Galanos-Demiris, Konstantinos, Zografos, George, Karavokyros, Ioannis, Xanthopoulou, Georgia, Iordanidou, Eirini, Ayau, Fernanda, Garcia, Allan, Damján, Pekli, Wason, Deepender, B L, Ashika, Rangganata, Ervandy, Kamath, Prerna, O'Connor, Donal B, Pinto, Margherita, Perrone, Fabrizio, Tropeano, Francesca Paola, Troilo, Francesca, Bossi, Daniela, Scala, Dario, Pulitanò, Lucrezia, Carella, Marcella, Pietrabissa, Andrea, Gori, Alice, Giraudo, Giorgio, De Simone, Veronica, Russo, Alfio Alessandro, Braccio, Bartolomeo, Al-Taher, Raed, Athamneh, Sarah, Parker, Andrea, Sawiee, Adnan, Kattia, Amina, Salem, Malik, Tababa, Osama, Shaeeb, Zuhour, Syminas, Vilius, Jurgaitis, Jonas, Damulevičienè, Gytè, Svagzdys, Saulius, Razafimanjato, Narindra Njarasoa Mihaja, Chieng Loo, Ling, Tiong, Ing Ching, Wan Muhmad, Wan Farahiyah, Vijeyan, Harinthiran, Li Ying, Teoh, Grech, Gabriella, Arrangoiz, Rodrigo, Jimenez Ley, Vania Brickelia, Arizpe, Daniel, Lagunes Lara, Elizabeth, Castro López, Elizabeth Victoria, Eaazim, Jose, Gordinou de Gouberville, Marije, Bastiaenen, Vivian, Rottier, Simone, Nahab, Fouad, Ji, Maria Yeonhee, Seyoji, Mohammed, Nwachukwu, Callistus, Emeghara, Okechukwu, Muhammed, Sayyid Egbunu, Idowu, Ayodeji, Sowemimo, Olamiposi, Ogundoyin, Olakayode, Akande, Oluwatosin, Lott, Alexander, Nadeem, Maliha, Laghari, Ahsan Ali, Loya, Asif, Mushtaq, Hassan, Abdullah, Muhammad Tariq, Abuhilal, Baseel, Atawneh, Mohammad, Hamdan, Hamdan, Alhabil, Belal, Srour, Abedelrahman, Mousa, Ibrahim, Da Silva Medina, Luis, Bartosiak, Katarzyna, Ferreira, Pedro, Francisco, Vítor, Lemos, Ricardo, Frutuoso, Luísa, Fernandes, Sara, Fonseca, Telma, Pereira, Jorge, Rachadell, Juan, Torre, Ana, Madeira Martins, Filipe, Carvalho, Ana Cristina, Rodrigues Ferreira, Joana, Ribeiro da Silva, Bruno, Devesa, Helena, Vieira, Ana, Mónica, Inês, Amaro, Margarida, Sousa, Diogo, Reia, Marta, Louro, João, Martins, Ana, Dominguez, Joaquina, Santos, Inês, Freitas Oliveira, Nuno Miguel, Pereira, José Carlos, Silva-Vaz, Pedro, Freire, Ligia, Escrevente, Ricardo, Negoita, Valentina Madalina, Shakhmatov, Dmitry, Nezerwa, Yves, Radulovic, Radosav, Obery, Gareth, Viljoen, Francois, Mendes, Tome, Suarez, Antonio, Moncada, Enrique, Fernandez-Hevia, Maria, Curtis Martínez, Carolina, Gil Garcia, Julia Maria, González Zunzarren, Mariana, Idris, Tarig, Eklöv, Karolina, Grahn, Oskar, Amin, Leila, Blomqvist, Malin, Ajani, Costanza, Kraus, Rebecca, Seeger, Nico, Willemin, Melissa, Rayya, Fadi, Ayash, Mohammad, Msouti, Raneem, Kannas, Israa, Abazid, Eias, Esper, Asil, Slim, Skander, Kavcar, Akil Serdar, Aytac, Erman, Dural, Ahmet Cem, Ilker, Ayse, Eray, Ismail Cem, Kurnaz, Eray, Altiner, Saygin, Tepe, Mustafa Deniz, Şahin, Can, Savli, Evrim, Innocent, Aryon, Babirye, Lilian, Diachenko, Andrii, Hordoskiy, Vladislav, Curry, Heather, Chau, Charlene Yat Che, Robertson, Harry, Mahmoud, Arin, Lennon, Hannah, Loi, Lynette, Kirkham, Emily, McCann, Cameron, Watts, Daniel, Gurung, Binay, Wilson, Michael, Tribedi, Thomas, Garofalo, Eleonora, Zahra, Baryab, MacDonald, Scott, Daniels, Ian, Ng, Nathan, Khosla, Shivun, Olivier, James, Yue, Sum Yu Pansy, Suresh, Gayathri, Wellington, Jack, Lorejo, Emmanuel, Mossaad, Mafdi, Crutcher, Madison, Alimi, Marjan, Baiu, Ioana, Abdou, Hossam, Conway, Alison, Peck, Connor, Perdomo Perez, Mauro Andres, Zulu, Stanley, Nakazwe, Mildred, Burger, Sule, Davies, Justine, Donaldson, Rachel, Ede, Chikwendu, Garden, O James, Lesetedi, Chiapo, Mabedi, Charles, Magill, Laura, Makinde Alakaloko, Felix, Makupe, Alex, Monahan, Mark, Mulira, Soloman, Muller, Elmi, Musowoyo, Jospeh, Olory-Togbe, Jean Léon, Roberts, Tracey, Smith, Martin, Tayler, Viki, Windsor, John, Yepez, Raul, Sundar, Sudha, Runigamugabo, Emmy, Verjee, Azmina, Chen, José, Daya, Leonid, El Aroussi, Nouhaila, Farina, Valeria, Gnintedeme Olivier, Tchianze, Gonzales Nacarino, Mauricio, Hammani, Aamr, Honjo, Sarah, Jacobs, Rebecca, Kimura, Hitomi, Nkoronko, Mugisha, Oscullo Yepez, Jasson Javier, Pin Hung, Wei, Raj, Ankit, Romani Pozo, Alina, Rommaneh, Muna, Sassamela Fabiano, Samuel Chimbioputo, Shiroma Gago, Camila Milagros, Srinivas, Abhishekh, Sung, Chia-Yen, Tai, Aswan, Valle Aranda, Yener Cristyell, Venturini, Sara, and Wilguens Lartigue, Jean

Published
2022
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38. Transitioning to Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer: Trends and Surgical Outcomes in a Regionalized Pulmonary Oncology Network

Author

Pilon, Yohann, Rokah, Merav, Seitlinger, Joseph, Sepesi, Boris, Rayes, Roni F., Cools-Lartigue, Jonathan, Najmeh, Sara, Sirois, Christian, Mulder, David, Ferri, Lorenzo, Abdulkarim, Bassam, Ezer, Nicole, Fraser, Richard, Camilleri-Broët, Sophie, Fiset, Pierre-Olivier, Wong, Annick, Sud, Shelly, Langleben, Adrian, Agulnik, Jason, Pepe, Carmela, Shieh, Benjamin, Hirsh, Vera, Ofiara, Linda, Owen, Scott, and Spicer, Jonathan D.

Published
2024
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41. Esophageal and gastric malignancies after bariatric surgery: a retrospective global study

Author

Gallardo, Carlos Sosa, Agustin, Cataldo, Wright, Fernando, Fuente, Ignacio, Carbajo, Miguel, Cal, Patricio, Chisholm, Jacob, Kow, Lilian, Tan, Michael H.L., Gan, Philip, Gananadha, Sivakumar, Felsenreich, Daniel M., Prager, Gerhard, Matthys, Chris, Himpens, Jacques M., Focquet, Marc A.M.R.M., Ramos, Almino, Nato, Manoel Galvano, Vidal, Thiago, Andalib, Amin, Siblini, Aya, Ferri, Lorenzo, Abdarabo, Lina, Nevo, Yehonatan, Pescarus, Radu, Yang, Wah, Hamed, Hosam, Liagre, Arnaud, Bergeat, Damien, Marie, De Montrichard, Martini, Francesco, Regis, François, Genser, Laurent, Skalli, Mehdi, Nedelcu, Marius, Smejkal, Milan, Kassir, Radwan, Nicolas, Regenet, Stier, Christine, Nedelcut, Dan-Sebastian, Christodoulidis, Grigorios, Vennapusa, Amar, Kermansaravi, Mohammad, Raziel, Asnat, Sakran, Nasser, Oldani, Alberto, Boru, Cristian Eugeniu, Mécheri, Fouzia, Ciccarese, Francesca, Cesana, Giovanni Carlo, Musella, Mario, Uccelli, Matteo, Foletto, Mirto, Auricchio, Pasquale, Olmi, Stefano, Seki, Yosuke, Kasteleijn, Anne, Van 'T Hof, Gerhard, Apers, Jan A., Hart, Judith W.H., Van De Sande, Justin S.L., Takkenberg, Marijn, Feskens, Pierre B.G.M., Snoekx, Rob, Plat, Victor D., Sandvik, Jorunn, Kalinowski, Piotr, Nabais, Celso, Al-Bahrani, Ahmed Z., Al Zoubi, Mohammad, Bettonica, Carla, Osorio, Javier, Tejedor-Tejada, Javier, Sanz, Lourdes M., Cuadrado, Marta, Moorjani, Rajesh Gianchandani, Yannick, Fringeli, Suter, Michel, Borbély, Yves, Joerg, Zehetner, Barajas-Gamboa, Juan S., Kroh, Matthew, Kisiel, Aaron P., Kamocka, Anna, Immanuel, Arul, Sgromo, Bruno, Gopinath, Bussa, Khoo, David, Mukherjee, Samrat, Pournaras, Dimitrios, Underwood, Tim, Griffiths, Ewen A., Miller, Glenn V., Jaretzke, Helen, Dmitrewski, Jan, Wadley, Martin S., Al-Housni, Ragad, Gillies, Richard S., Singhal, Rishi, Preston, Shaun R., Robinson, Steven John, Hawkins, William J., Adamo, Marco, El Kalaawy, Mohamed, Gossage, James, Crawford, Christopher B., Jaruvongvanich, Veeravich, Parmar, Chetan, Zakeri, Roxanna, Abouelazayem, Mohamed, Shin, Thomas H., Aminian, Ali, Mahmoud, Tala, Abu Dayyeh, Barham K., Wee, Melissa Y., Fischer, Laura, Daams, Freek, and Mahawar, Kamal

Published
2022
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44. Surgical and radiosurgical treatment of hypothalamic hamartoma: The Italian experience between 2011 and 2021.

Author

Rizzi, Michele, Consales, Alessandro, Tramacere, Irene, De Benedictis, Alessandro, Bua, Antonella, Specchio, Nicola, De Palma, Luca, Cognolato, Erica, Nobili, Lino, Tortora, Domenico, Barba, Carmen, Pommella, Marianna, Giordano, Flavio, Pastori, Chiara, Marchetti, Marcello, Garbelli, Rita, Zucchelli, Mino, Martinoni, Matteo, Ferri, Lorenzo, and Martucci, Matia

Subjects
EPILEPSY surgery, STEREOTACTIC radiosurgery, PEOPLE with epilepsy, UNIVARIATE analysis, SEIZURES (Medicine)
Abstract

Objective: To investigate the Italian experience on the surgical and radiosurgical treatment of drug‐resistant epilepsy due to hypothalamic hamartoma (HH) in the period 2011–2021 in six Italian epilepsy surgery centers, and to compare safety and efficacy profiles of the different techniques. Methods: We collected pseudo‐anonymized patient's data with at least 12 months of follow‐up. Surgical outcome was defined according to Engel classification of seizure outcome. Univariate analysis was performed to assess the risk of post‐operative seizures, categorized in dichotomous variable as favorable and unfavorable; explanatory variables were considered. Mann–Whitney or Chi‐squared test were used to assess the presence of an association between variables (p < 0.05). Results: Full presurgical and postoperative data about 42 patients from 6 epilepsy surgery centers were gathered. Engel class I was reached in the 65.8% and 66.6% of patients with gelastic and non‐gelastic seizures, respectively. Other than daily non‐gelastic seizures were associated with seizure freedom (p = 0.01), and the radiological type presented a trend toward significance (p = 0.12). Significance: Endoscopic disconnection and laser interstitial thermal therapy are effective in the treatment of HH‐related epilepsy, with a tolerable safety profile. Both gelastic and non‐gelastic seizures can be treated, also in patients with a long history of seizures. Plain Language Summary: This study collected data about 42 patients with HH‐related epilepsies. Endoscopic disconnection and laser therapy are both effective and safe in the treatment of hypothalamic hamartoma‐related epilepsies. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Efficacy of Endoscopic Submucosal Dissection for Superficial Gastric Neoplasia in a Large Cohort in North America

Author

Ngamruengphong, Saowanee, Ferri, Lorenzo, Aihara, Hiroyuki, Draganov, Peter V., Yang, Dennis J., Perbtani, Yaseen B., Jue, Terry L., Munroe, Craig A., Boparai, Eshandeep S., Mehta, Neal A., Bhatt, Amit, Kumta, Nikhil A., Othman, Mohamed O., Mercado, Michael, Javaid, Huma, Aadam, Abdul Aziz, Siegel, Amanda, James, Theodore W., Grimm, Ian S., DeWitt, John M., Novikov, Aleksey, Schlachterman, Alexander, Kowalski, Thomas, Samarasena, Jason, Hashimoto, Rintaro, Chehade, Nabil El Hage, Lee, John, Chang, Kenneth, Su, Bailey, Ujiki, Michael B., Mehta, Amit, Sharaiha, Reem Z., Carr-Locke, David L., Chen, Alex, Chen, Michael, Chen, Yen-I., Pourmousavi Khoshknab, MirMilad, Wang, Rui, Kerdsirichairat, Tossapol, Tomizawa, Yutaka, von Renteln, Daniel, Kumbhari, Vivek, Khashab, Mouen A., Bechara, Robert, Karasik, Michael, Patel, Neej J., Fukami, Norio, Nishimura, Makoto, Hanada, Yuri, Wong Kee Song, Louis M., Laszkowska, Monika, Wang, Andrew Y., Hwang, Joo Ha, Friedland, Shai, Sethi, Amrita, and Kalloo, Antony N.

Published
2021
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49. Intravenous immunoglobulin therapy in COVID-19-related encephalopathy

Author

Muccioli, Lorenzo, Pensato, Umberto, Bernabè, Giorgia, Ferri, Lorenzo, Tappatà, Maria, Volpi, Lilia, Cani, Ilaria, Henry, Olivia J., Ceccaroni, Francesca, Cevoli, Sabina, Stofella, Gloria, Pasini, Elena, Fornaro, Giacomo, Tonon, Caterina, Vidale, Simone, Liguori, Rocco, Tinuper, Paolo, Michelucci, Roberto, Cortelli, Pietro, and Bisulli, Francesca

Published
2021
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50. An International Cohort Study of Prognosis Associated With Pathologically Complete Response Following Neoadjuvant Chemotherapy Versus Chemoradiotherapy of Surgical Treated Esophageal Adenocarcinoma

Author

Cools-Lartigue, Jonathan, Markar, Sheraz, Mueller, Carmen, Hofstetter, Wayne, Nilsson, Magnus, Ilonen, Ilkka, Soderstrom, Henna, Rasanen, Jari, Gisbertz, Suzanne, Hanna, George B., Elliott, Jessie, Reynolds, John, Kisiel, Aaron, Griffiths, Ewen, Van Berge Henegouwen, Mark, and Ferri, Lorenzo

Published
2022
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