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614 results on '"Fauser, Bart"'

7. Guidelines for the design, analysis and interpretation of ‘omics’ data: focus on human endometrium

Author

Altmäe, Signe, Esteban, Francisco J, Stavreus-Evers, Anneli, Simón, Carlos, Giudice, Linda, Lessey, Bruce A, Horcajadas, Jose A, Macklon, Nick S, D'Hooghe, Thomas, Campoy, Cristina, Fauser, Bart C, Salamonsen, Lois A, and Salumets, Andres

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Genetics, Biotechnology, Human Genome, Generic health relevance, Embryo Implantation, Endometrium, Female, Genomics, Guidelines as Topic, High-Throughput Nucleotide Sequencing, Humans, Metabolomics, Systems Biology, endometrium, epigenomics, genomics, metabolomics, proteomics, Clinical Sciences, Paediatrics and Reproductive Medicine, Public Health and Health Services, Obstetrics & Reproductive Medicine, Reproductive medicine
Abstract

Background'Omics' high-throughput analyses, including genomics, epigenomics, transcriptomics, proteomics and metabolomics, are widely applied in human endometrial studies. Analysis of endometrial transcriptome patterns in physiological and pathophysiological conditions has been to date the most commonly applied 'omics' technique in human endometrium. As the technologies improve, proteomics holds the next big promise for this field. The 'omics' technologies have undoubtedly advanced our knowledge of human endometrium in relation to fertility and different diseases. Nevertheless, the challenges arising from the vast amount of data generated and the broad variation of 'omics' profiling according to different environments and stimuli make it difficult to assess the validity, reproducibility and interpretation of such 'omics' data. With the expansion of 'omics' analyses in the study of the endometrium, there is a growing need to develop guidelines for the design of studies, and the analysis and interpretation of 'omics' data.MethodsSystematic review of the literature in PubMed, and references from relevant articles were investigated up to March 2013.ResultsThe current review aims to provide guidelines for future 'omics' studies on human endometrium, together with a summary of the status and trends, promise and shortcomings in the high-throughput technologies. In addition, the approaches presented here can be adapted to other areas of high-throughput 'omics' studies.ConclusionA highly rigorous approach to future studies, based on the guidelines provided here, is a prerequisite for obtaining data on biological systems which can be shared among researchers worldwide and will ultimately be of clinical benefit.

Published
2014

8. Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature.

Author

Fauser, Bart C J M, Adamson, G David, Boivin, Jacky, Chambers, Georgina M, Geyter, Christian de, Dyer, Silke, Inhorn, Marcia C, Schmidt, Lone, Serour, Gamal I, Tarlatzis, Basil, Zegers-Hochschild, Fernando, and Board, Contributors and members of the IFFS Demographics and Access to Care Review

Subjects
*LITERATURE reviews, *FAMILY planning, *CONSTRUCTION planning, *INFERTILITY, *FERTILITY decline, *UNPLANNED pregnancy, *MARRIED women, *SURROGATE mothers
Abstract

BACKGROUND Family-planning policies have focused on contraceptive approaches to avoid unintended pregnancies, postpone, or terminate pregnancies and mitigate population growth. These policies have contributed to significantly slowing world population growth. Presently, half the countries worldwide exhibit a fertility rate below replacement level. Not including the effects of migration, many countries are predicted to have a population decline of >50% from 2017 to 2100, causing demographic changes with profound societal implications. Policies that optimize chances to have a child when desired increase fertility rates and are gaining interest as a family-building method. Increasingly, countries have implemented child-friendly policies (mainly financial incentives in addition to public funding of fertility treatment in a limited number of countries) to mitigate decreasing national populations. However, the extent of public spending on child benefits varies greatly from country to country. To our knowledge, this International Federation of Fertility Societies (IFFS) consensus document represents the first attempt to describe major disparities in access to fertility care in the context of the global trend of decreasing growth in the world population, based on a narrative review of the existing literature. OBJECTIVE AND RATIONALE The concept of family building , the process by which individuals or couples create or expand their families, has been largely ignored in family-planning paradigms. Family building encompasses various methods and options for individuals or couples who wish to have children. It can involve biological means, such as natural conception, as well as ART, surrogacy, adoption, and foster care. Family-building acknowledges the diverse ways in which individuals or couples can create their desired family and reflects the understanding that there is no one-size-fits-all approach to building a family. Developing education programs for young adults to increase family-building awareness and prevent infertility is urgently needed. Recommendations are provided and important knowledge gaps identified to provide professionals, the public, and policymakers with a comprehensive understanding of the role of child-friendly policies. SEARCH METHODS A narrative review of the existing literature was performed by invited global leaders who themselves significantly contributed to this research field. Each section of the review was prepared by two to three experts, each of whom searched the published literature (PubMed) for peer reviewed full papers and reviews. Sections were discussed monthly by all authors and quarterly by the review board. The final document was prepared following discussions among all team members during a hybrid invitational meeting where full consensus was reached. OUTCOMES Major advances in fertility care have dramatically improved family-building opportunities since the 1990s. Although up to 10% of all children are born as a result of fertility care in some wealthy countries, there is great variation in access to care. The high cost to patients of infertility treatment renders it unaffordable for most. Preliminary studies point to the increasing contribution of fertility care to the global population and the associated economic benefits for society. WIDER IMPLICATIONS Fertility care has rarely been discussed in the context of a rapid decrease in world population growth. Soon, most countries will have an average number of children per woman far below the replacement level. While this may have a beneficial impact on the environment, underpopulation is of great concern in many countries. Although governments have implemented child-friendly policies, distinct discrepancies in access to fertility care remain. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Early Onset of Coronary Artery Calcification in Women With Previous Preeclampsia

Author

Benschop, Laura, Brouwers, Laura, Zoet, Gerbrand A., Meun, Cindy, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., de Groot, Christianne M.J., van der Schouw, Yvonne T., Maas, Angela H.E.M., Velthuis, Birgitta K., Linstra, Katie M., Kavousi, Maryam, Duvekot, Johannes J., Franx, Arie, Steegers, Eric, van Rijn, Bas B., and Roeters van Lennep, Jeanine E.

Published
2020
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19. Prevalence of Subclinical Coronary Artery Disease Assessed by Coronary Computed Tomography Angiography in 45- to 55-Year-Old Women With a History of Preeclampsia

Author

Zoet, Gerbrand A., Benschop, Laura, Boersma, Eric, Budde, Ricardo P.J., Fauser, Bart C.J.M., van der Graaf, Yolanda, de Groot, Christianne J.M., Maas, Angela H.E.M., Roeters van Lennep, Jeanine E., Steegers, Eric A.P., Visseren, Frank L., van Rijn, Bas B., Velthuis, Birgitta K., Franx, Arie, Appelman, Yolande E., Baart, Sara J., Brouwers, Laura, Cannegieter, Suzanne C., Dam, Veerle, Eijkemans, M.C.J., Ferrari, Michel D., Gunning, Marlise N., Hoek, Annemieke, Koffijberg, Erik, Koster, M.P.H., Kruit, Mark, Lagerwij, Giske R., Lambalk, C.B., Laven, Joop S., Linstra, Katie, van der Lugt, Aad, Maassen van den Brink, Antoinette, Meun, Cindy, Middeldorp, Saskia, Moons, Karel G.M., Roos-Hesselink, Jolien W., Scheres, Luuk J.J., Steegers-Theunissen, Regine P.M., Terwindt, Gisela M., and Wermer, Marieke J.H.

Published
2018
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20. Change in Androgenic Status and Cardiometabolic Profile of Middle-Aged Women with Polycystic Ovary Syndrome.

Author

van der Ham, Kim, Koster, Maria P. H., Velthuis, Birgitta K., Budde, Ricardo P. J., Fauser, Bart C. J. M., Laven, Joop S. E., and Louwers, Yvonne V.

Subjects
POLYCYSTIC ovary syndrome, MIDDLE-aged women, HDL cholesterol, HYPERTENSION, BODY mass index, CARDIOVASCULAR diseases, DYSLIPIDEMIA
Abstract

Understanding the cardiovascular disease (CVD) risk for women with polycystic ovary syndrome (PCOS) at reproductive age is crucial. To investigate this, we compared the cardiometabolic profiles of different PCOS groups over a median interval of 15.8 years. The study focused on three groups: (1) women with PCOS who were hyperandrogenic at both initial and follow-up screening (HA-HA), (2) those who transitioned from hyperandrogenic to normoandrogenic (HA-NA), and (3) those who remained normoandrogenic (NA-NA). At initial and follow-up screenings, both HA-HA and HA-NA groups showed higher body mass indexes compared to the NA-NA group. Additionally, at follow-up, the HA-HA and HA-NA groups exhibited higher blood pressure, a higher prevalence of hypertension, elevated serum triglycerides and insulin levels, and lower levels of HDL cholesterol compared to the NA-NA group. Even after adjusting for BMI, significant differences persisted in HDL cholesterol levels and hypertension prevalence among the groups (HA-HA: 53.8%, HA-NA: 53.1%, NA-NA: 14.3%, p < 0.01). However, calcium scores and the prevalence of coronary plaques on CT scans were similar across all groups. In conclusion, women with PCOS and hyperandrogenism during their reproductive years exhibited an unfavorable cardiometabolic profile during their post-reproductive years, even if they changed to a normoandrogenic status. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Improving the Reporting of Clinical Trials of Infertility Treatments (IMPRINT): modifying the CONSORT statement†‡

Author

Legro, Richard S., Wu, Xiaoke, Barnhart, Kurt T., Farquhar, Cynthia, Fauser, Bart C.J.M., Mol, Ben, Legro, Richard S., Wu, Xiaoke, Barnhart, Kurt, Niederberger, Craig, Ng, Ernest H.Y., Palomba, Stefano, Maria, Arcispedale S., Emilia, Reggio, Zhang, Heping, Farquhar, Cindy, Rebar, Robert W., Pellicer, Antonio, Reindollar, Richard, Fauser, Bart C.J.M., Tapanainen, Juha S., Evers, Hans, Shankaran, Seetha, Silver, Robert M., Mol, Ben, Norman, Robert J, Silver, Robert M., Bhattacharya, Siladitya, Vanderpoel, Sheryl, Bhattacharya, Siladitya, Evers, Johannes L., Ng, Ernest H.Y., Niederberger, Craig, Norman, Robert J., Palomba, Stefano, Pellicer, Antonio, Reindollar, Richard, Rebar, Robert, Shankaran, Seetha, Silver, Robert M., Tapanainen, Juha S., Vanderpool, Sheryl, and Zhang, Heping

Published
2014
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40. Sex Steroid Hormones and Reproductive Disorders: Impact on Women’s Health

Author

Fauser, Bart C. J. M., Laven, Joop S. E., Tarlatzis, Basil C., Moley, Kelle H., Critchley, Hilary O. D., Taylor, Robert N., Berga, Sarah L., Mermelstein, Paul G., Devroey, Paul, Gianaroli, Luca, D’Hooghe, Thomas, Vercellini, Paolo, Hummelshoj, Lone, Rubin, Susan, Goverde, Angelique J., De Leo, Vincenzo, and Petraglia, Felice

Published
2011
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47. A mild treatment strategy for in-vitro fertilisation: a randomised non-inferiority trial

Author

Heijnen, Esther M.E.W., Eijkemans, Marinus J.C., De Klerk, Cora, Polinder, Suzanne, Beckers, Nicole G.M., Klinkert, Ellen R., Broekmans, Frank J., Passchier, Jan, Te Velde, Egbert R., Macklon, Nick S., and Fauser, Bart C.J.M.

Subjects
Fertilization in vitro -- Methods, Fertilization in vitro -- Patient outcomes, Fertilization in vitro -- Research, Medical care, Cost of -- Research
Published
2007

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